keyword
https://read.qxmd.com/read/38491434/utilizing-the-national-early-warning-score-2-news2-to-confirm-the-impact-of-emergency-department-management-in-sepsis-patients-a-cohort-study-from-taiwan-1998-2020
#1
JOURNAL ARTICLE
Ming-Shun Hsieh, Kuan-Chih Chiu, Amrita Chattopadhyay, Tzu-Pin Lu, Shu-Hui Liao, Chia-Ming Chang, Yi-Chen Lee, Wei-En Lo, Vivian Chia-Rong Hsieh, Sung-Yuan Hu, Chorng-Kuang How
BACKGROUND: Most sepsis patients could potentially experience advantageous outcomes from targeted medical intervention, such as fluid resuscitation, antibiotic administration, respiratory support, and nursing care, promptly upon arrival at the emergency department (ED). Several scoring systems have been devised to predict hospital outcomes in sepsis patients, including the Sequential Organ Failure Assessment (SOFA) score. In contrast to prior research, our study introduces the novel approach of utilizing the National Early Warning Score 2 (NEWS2) as a means of assessing treatment efficacy and disease progression during an ED stay for sepsis...
March 15, 2024: International Journal of Emergency Medicine
https://read.qxmd.com/read/38485953/identification-of-a-hyperinflammatory-sepsis-phenotype-using-protein-biomarker-and-clinical-data-in-the-process-randomized-trial
#2
JOURNAL ARTICLE
Kimberley M DeMerle, Jason N Kennedy, Chung-Chou H Chang, Kevin Delucchi, David T Huang, Max S Kravitz, Nathan I Shapiro, Donald M Yealy, Derek C Angus, Carolyn S Calfee, Christopher W Seymour
Sepsis is a heterogeneous syndrome and phenotypes have been proposed using clinical data. Less is known about the contribution of protein biomarkers to clinical sepsis phenotypes and their importance for treatment effects in randomized trials of resuscitation. The objective is to use both clinical and biomarker data in the Protocol-Based Care for Early Septic Shock (ProCESS) randomized trial to determine sepsis phenotypes and to test for heterogeneity of treatment effect by phenotype comparing usual care to protocolized early, goal-directed therapy(EGDT)...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38481478/machine-learning-predictive-model-for-septic-shock-in-acute-pancreatitis-with-sepsis
#3
JOURNAL ARTICLE
Yiqin Xia, Hongyu Long, Qiang Lai, Yiwu Zhou
OBJECTIVE: Acute pancreatitis (AP) progresses to septic shock can be fatal. Early identification of high-risk patients and timely intervention can prevent and interrupt septic shock. By analyzing the clinical characteristics of AP with sepsis, this study uses machine learning (ML) to build a model for early prediction of septic shock within 28 days of admission, which guided emergency physicians in resource allocation and medical decision-making. METHODS: This retrospective cohort study collected data from the emergency departments (EDs) of three tertiary care hospitals in China...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38476536/value-of-procalcitonin-and-presepsin-in-the-diagnosis-and-severity-stratification-of-sepsis-and-septic-shock
#4
JOURNAL ARTICLE
Enfeng Ren, Hongli Xiao, Guoxing Wang, Yongzhen Zhao, Han Yu, Chunsheng Li
No abstract text is available yet for this article.
2024: World Journal of Emergency Medicine
https://read.qxmd.com/read/38471759/emergency-department-sepsis-triage-scoring-tool-elements-associated-with-hypotension-within-24-hours-in-children-with-fever-and-tachycardia
#5
JOURNAL ARTICLE
Alexandra H Baker, Vanessa M Mazandi, Jackson S Norton, Elliot Melendez
OBJECTIVE: Pediatric sepsis screening is becoming the standard of care for children presenting to the emergency department (ED) and has been shown to improve recognition of severe sepsis, but it is unknown if these screening tools can predict progression of disease. The objective of this study was to determine if any elements of a sepsis triage trigger tool were predictive of progression to hypotensive shock in children presenting to the ED with fever and tachycardia. METHODS: This study is a retrospective case-control study of children ≤18 years presenting to an ED with fever and tachycardia, comparing those who went on to develop hypotensive shock in the subsequent 24 hours (case) to those who did not (control)...
March 13, 2024: Pediatric Emergency Care
https://read.qxmd.com/read/38470467/evaluating-sepsis-bundle-compliance-as-a-predictor-for-patient-outcomes-at-a-community-hospital-a-retrospective-study
#6
JOURNAL ARTICLE
John R Lawrence, Ben Seiyon Lee, Adetokunbo I Fadahunsi, Bernice D Mowery
BACKGROUND: Clinicians are encouraged to use the Centers for Medicare & Medicaid Services early management bundle for severe sepsis and septic shock (SEP-1); however, it is unclear whether this process measure improves patient outcomes. PURPOSE: The purpose of this study was to evaluate whether compliance with the SEP-1 bundle is a predictor of hospital mortality, length of stay (LOS), and intensive care unit LOS at a suburban community hospital. METHODS: A retrospective observational study was conducted...
March 11, 2024: Journal of Nursing Care Quality
https://read.qxmd.com/read/38470396/a-tagging-polymorphism-in-fat-mass-and-obesity-associated-fto-gene-is-associated-with-sepsis-status-in-children
#7
JOURNAL ARTICLE
Petr Jabandziev, Jaroslav Alois Hubacek, Jaroslav Michalek, Martin Jouza, Jan Papez, Jakub Pecl, Katerina Slaba, Ondrej Slaby, Milan Urik, Stefania Aulicka, Lumir Kunovsky, Jaroslav Michalek, Petr Dominik, Milan Kratochvil, Jozef Klucka, Petr Stourac
INTRODUCTION: Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated ( FTO ) gene and risk of sepsis in children and adolescents. METHODS: We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0-19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults...
March 12, 2024: Romanian Journal of Internal Medicine
https://read.qxmd.com/read/38465952/biomarker-assessment-of-a-high-risk-data-driven-pediatric-sepsis-phenotype-characterized-by-persistent-hypoxemia-encephalopathy-and-shock
#8
JOURNAL ARTICLE
Mihir R Atreya, Tellen D Bennett, Alon Geva, E Vincent S Faustino, Colin M Rogerson, Riad Lutfi, Natalie Z Cvijanovich, Michael T Bigham, Jeffrey Nowak, Adam J Schwarz, Torrey Baines, Bereketeab Haileselassie, Neal J Thomas, Yuan Luo, L Nelson Sanchez-Pinto
OBJECTIVES: Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. We sought to the determine reproducibility of the data-driven "persistent hypoxemia, encephalopathy, and shock" (PHES) phenotype and determine its association with inflammatory and endothelial biomarkers, as well as biomarker-based pediatric risk strata. DESIGN: We retrained and validated a random forest classifier using organ dysfunction subscores in the 2012-2018 electronic health record (EHR) dataset used to derive the PHES phenotype...
March 11, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38465637/vascular-reactivity-index-as-an-effective-predictor-of-mortality-in-patients-with-septic-shock-a-retrospective-study
#9
JOURNAL ARTICLE
Sun Jingyi, Gao Cunliang, Chen Biao, Xie Yingguang, Ma Jinluan, Cao Xiaohua, Li Wenqiang
BACKGROUND: Sepsis is a serious complication that occurs after trauma, burns, and infections, and it is an important cause of death in intensive care unit (ICU) patients. Despite many new measures being proposed for sepsis treatment, its mortality rate remains high; sepsis has become a serious threat to human health, and there is an urgent need to carry out in-depth clinical research related to sepsis. In recent years, it has been found that septic shock-induced vasoplegia is a result of vascular hyporesponsiveness to vasopressors...
March 11, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38465049/a-case-of-klippel-trenaunay-syndrome-complicated-by-group-a-streptococcemia-and-multiple-organ-failure
#10
Ramaditya Srinivasmurthy, George Gilles, Tha Sok, Brian Chang
Klippel-Trenaunay syndrome (KTS) is a rare congenital disorder defined as a triad of capillary malformation, venous malformation, and hypertrophy of soft tissue and bones, with or without lymphatic malformation. We report a case of a KTS patient with a hospital course complicated by Group A Streptococcus bacteremia and multiple organ failure. The 39-year-old female with KTS presented to the emergency department with a fever, tachycardia, hypotension, and profuse diarrhea for one week. Blood cultures grew Group A Streptococcus necessitating a multi-antibiotic regimen and intravenous immunoglobulins (IVIG)...
February 2024: Curēus
https://read.qxmd.com/read/38462275/prognostic-prediction-of-sepsis-patient-using-transformer-with-skip-connected-token-for-tabular-data
#11
JOURNAL ARTICLE
Jee-Woo Choi, Minuk Yang, Jae-Woo Kim, Yoon Mi Shin, Yong-Goo Shin, Seung Park
Sepsis is known as a common syndrome in intensive care units (ICU), and severe sepsis and septic shock are among the leading causes of death worldwide. The purpose of this study is to develop a deep learning model that supports clinicians in efficiently managing sepsis patients in the ICU by predicting mortality, ICU length of stay (>14 days), and hospital length of stay (>30 days). The proposed model was developed using 591 retrospective data with 16 tabular data related to a sequential organ failure assessment (SOFA) score...
March 2024: Artificial Intelligence in Medicine
https://read.qxmd.com/read/38461810/tlrs1-10-protein-expression-in-circulating-human-white-blood-cells-during-bacterial-and-covid-19-infections
#12
Louise Chomel, Mathieu Vogt, Julien Demiselle, Pierrick Le Borgne, Marine Tschirhart, Valentin Morandeau, Hamid Merdji, Laurent Miguet, Julie Helms, Ferhat Meziani, Laurent Mauvieux
INTRODUCTION: Toll-like receptors play crucial roles in sepsis-induced systemic inflammatory response. Septic shock mortality correlates with overexpression of neutrophilic TLR2 and TLR9, while the role of TLR4 overexpression remains a debate. In addition, TLRs are involved in the pathogenesis of viral infections such as COVID-19, where the single-stranded RNA of SARS-CoV-2 is recognized by TLR7 and TLR8, and the spike protein activates TLR4. METHODS: In this study, we conducted a comprehensive analysis of TLRs 1-10 expressions in white blood cells from 71 patients with bacterial and viral infections...
March 8, 2024: Journal of Innate Immunity
https://read.qxmd.com/read/38457556/late-onset-neonatal-sepsis-can-plasma-gelsolin-be-a-promising-diagnostic-marker
#13
JOURNAL ARTICLE
Wesam A Mokhtar, Laila M Sherief, Naglaa M Kamal, Azza O ElSheikh, Farida H Omran, Ahmed Abdulsaboor, Maha M H Sakr, Shreif El Gebally, Mohamed M M Shehab, Jaber Alfaifi, Reem Turkistani, Futun Aljuaid, Mohammed A M Oshi, Fouad B A Elbekoushi, Ghada A Mokhtar
Plasma gelsolin (pGSN) correlates with clinical improvement in septic patients. We aimed to investigate pGSN levels as a diagnostic and prognostic marker of neonatal late-onset-sepsis (LOS). A case-control study was done on 184 neonates (92 with LOS and 92 controls). All participants were subjected to detailed history taking, full clinical evaluation, sepsis workup, and pGSN enzyme-linked immunosorbent-assay measurement. We detected significantly lower pGSN level among cases compared to controls (90.63 ± 20...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38446263/circulating-n-lactoyl-amino-acids-and-n-formyl-methionine-reflect-mitochondrial-dysfunction-and-predict-mortality-in-septic-shock
#14
JOURNAL ARTICLE
Robert S Rogers, Rohit Sharma, Hardik B Shah, Owen S Skinner, Xiaoyan A Guo, Apekshya Panda, Rahul Gupta, Timothy J Durham, Kelsey B Shaughnessy, Jared R Mayers, Kathryn A Hibbert, Rebecca M Baron, B Taylor Thompson, Vamsi K Mootha
INTRODUCTION: Sepsis is a highly morbid condition characterized by multi-organ dysfunction resulting from dysregulated inflammation in response to acute infection. Mitochondrial dysfunction may contribute to sepsis pathogenesis, but quantifying mitochondrial dysfunction remains challenging. OBJECTIVE: To assess the extent to which circulating markers of mitochondrial dysfunction are increased in septic shock, and their relationship to severity and mortality. METHODS: We performed both full-scan and targeted (known markers of genetic mitochondrial disease) metabolomics on plasma to determine markers of mitochondrial dysfunction which distinguish subjects with septic shock (n = 42) from cardiogenic shock without infection (n = 19), bacteremia without sepsis (n = 18), and ambulatory controls (n = 19) - the latter three being conditions in which mitochondrial function, proxied by peripheral oxygen consumption, is presumed intact...
March 6, 2024: Metabolomics: Official Journal of the Metabolomic Society
https://read.qxmd.com/read/38445412/the-combination-of-kidney-function-variables-with-cell-cycle-arrest-biomarkers-identifies-distinct-subphenotypes-of-sepsis-associated-acute-kidney-injury-a-post-hoc-analysis-the-phenaki-study
#15
MULTICENTER STUDY
Dimitri Titeca-Beauport, Momar Diouf, Delphine Daubin, Ly Van Vong, Guillaume Belliard, Cédric Bruel, Yoann Zerbib, Christophe Vinsonneau, Kada Klouche, Julien Maizel
BACKGROUND: The severity and course of sepsis-associated acute kidney injury (SA-AKI) are correlated with the mortality rate. Early detection of SA-AKI subphenotypes might facilitate the rapid provision of individualized care. PATIENTS AND METHODS: In this post-hoc analysis of a multicenter prospective study, we combined conventional kidney function variables with serial measurements of urine (tissue inhibitor of metalloproteinase-2 [TIMP-2])* (insulin-like growth factor-binding protein [IGFBP7]) at 0, 6, 12, and 24 h) and then using an unsupervised hierarchical clustering of principal components (HCPC) approach to identify different phenotypes of SA-AKI...
December 2024: Renal Failure
https://read.qxmd.com/read/38415021/sequential-extracorporeal-therapy-of-pathogen-removal-followed-by-cell-directed-extracorporeal-therapy-in-streptococcal-toxic-shock-syndrome-refractory-to-venoarterial-extracorporeal-membrane-oxygenation-a-case-report
#16
Stephen J Amerson, McKenna Hoffman, Fadi Abouzahr, Mohammad Ahmad, Rachel K Sterling, Hitesh Gidwani, Linda E Sousse, Jeffrey D Dellavolpe
BACKGROUND: Streptococcal toxic shock syndrome (STSS) is a fulminant complication of predominantly invasive group A streptococcal infections. STSS is often characterized by influenza-like symptoms, including fever, chills, and myalgia that can quickly progress to sepsis with hypotension, tachycardia, tachypnea, and multiple organ failure (kidney, liver, lung, or blood). Mortality can exceed 50% depending on the severity of symptoms. CASE SUMMARY: Here, we describe a novel, multi-extracorporeal intervention strategy in a case of severe septic shock secondary to STSS...
March 2024: Critical care explorations
https://read.qxmd.com/read/38410595/shenfu-injection-as-treatment-for-critical-illness-a-narrative-review-of-clinical-trials
#17
REVIEW
Noa Berlin, Aditya C Shekhar, Katherine M Berg
BACKGROUND AND OBJECTIVE: Shenfu injection (SFI) is a traditional herbal medicine derived from components of ginseng and aconite and is commonly used in China to treat a variety of conditions. Shenfu has been suggested to have beneficial effects in various critical illnesses, including heart failure, cardiac arrest, and septic shock. In recent years, there have been a number of studies reporting that SFI improves patient outcomes when used concurrently with other treatments, but its use has not been adopted outside of China...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38404267/-analysis-of-the-current-quality-of-life-status-and-influencing-factors-of-sepsis-survivors-in-intensive-care-unit
#18
JOURNAL ARTICLE
Cuiping Hao, Qiuhua Li, Cuicui Zhang, Fenfen Zhang, Yaqing Zhang, Lina Zhu, Huanhuan Cheng, Yinghao Li, Qinghe Hu
OBJECTIVE: To explore the current situation and influencing factors of quality of life of septic patients in intensive care unit (ICU) after discharge, and to provide theoretical basis for clinical early psychological intervention and continuity of care. METHODS: A prospective observational study was conducted. The septic patients who were hospitalized in the department of critical care medicine of the Affiliated Hospital of Jining Medical University and discharged with improvement from January 1 to December 31, 2022 were selected as the research objects...
January 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38403531/fractional-excretion-of-sodium-and-potassium-and-urinary-strong-ion-difference-in-the-evaluation-of-persistent-aki-in-sepsis
#19
JOURNAL ARTICLE
Nicolás Contrera Rolón, Joaquín Cantos, Iván Huespe, Eduardo Prado, Griselda I Bratti, Carlos Schreck, Sergio Giannasi, Guillermo Rosa Diez, Carlos F Varela
OBJECTIVE: To evaluate the diagnostic performance of FENa (Fractional excretion of sodium), FEK (fractional excretion of potassium) and uSID (urinary strong ion difference) in predicting pAKI in sepsis and septic shock. DESIGN: Retrospective cohort study. SETTING: Two intensive care units in Argentina. PATIENTS: Adult patients with a confirmed diagnosis of sepsis or septic shock and AKI, and had a urinary biochemistry within 24h of the AKI diagnosis...
February 24, 2024: Medicina intensiva
https://read.qxmd.com/read/38398425/severe-lung-dysfunction-and-pulmonary-blood-flow-during-extracorporeal-membrane-oxygenation
#20
JOURNAL ARTICLE
Lars Falk, Marika Lidegran, Sandra Diaz Ruiz, Jan Hultman, Lars Mikael Broman
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is indicated for patients with severe respiratory and/or circulatory failure. The standard technique to visualize the extent of pulmonary damage during ECMO is computed tomography (CT). PURPOSE: This single-center, retrospective study investigated whether pulmonary blood flow (PBF) measured with echocardiography can assist in assessing the extent of pulmonary damage and whether echocardiography and CT findings are associated with patient outcomes...
February 16, 2024: Journal of Clinical Medicine
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