Petr Jabandziev, Jaroslav Alois Hubacek, Jaroslav Michalek, Martin Jouza, Jan Papez, Jakub Pecl, Katerina Slaba, Ondrej Slaby, Milan Urik, Stefania Aulicka, Lumir Kunovsky, Jaroslav Michalek, Petr Dominik, Milan Kratochvil, Jozef Klucka, Petr Stourac
INTRODUCTION: Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated ( FTO ) gene and risk of sepsis in children and adolescents. METHODS: We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0-19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults...
March 12, 2024: Romanian Journal of Internal Medicine