keyword
https://read.qxmd.com/read/38130643/hypervolemia-suppresses-dilutional-anaemic-injury-in-a-rat-model-of-haemodilution
#21
JOURNAL ARTICLE
Muzaffer Utku Cakir, Berna Yavuz-Aksu, Ugur Aksu
BACKGROUND AND OBJECTIVES: Haemodilution leads to complications in clinical practice. It is exactly unknown whether this damage is caused by the fluid or by the stretching of the vascular bed. We aimed to compare two different haemodilution techniques at the same anaemic level. METHODS: Normovolemic or hypervolemic haemodilution was performed on twelve adult male Wistar rats. In the normovolemic procedure, blood was withdrawn and instantaneously administered with similar amounts of 6% hydroxyethyl starch (HES 130/0...
December 2023: Journal of Translational Internal Medicine
https://read.qxmd.com/read/38111338/use-of-intraoperative-haemoadsorption-in-patients-undergoing-heart-transplantation-a-proof-of-concept-randomized-trial
#22
JOURNAL ARTICLE
Endre Nemeth, Adam Soltesz, Eniko Kovacs, Zsofia Szakal-Toth, Eszter Tamaska, Hajna Katona, Kristof Racz, Gergely Csikos, Viktor Berzsenyi, Szabolcs Fabry, Zsuzsanna Ulakcsai, Csilla Tamas, Beata Nagy, Marina Varga, Bela Merkely
AIMS: The aim of this trial was to compare the clinical effects of intraoperative haemoadsorption versus standard care in patients undergoing orthotopic heart transplantation (OHT). METHODS AND RESULTS: In a randomized, controlled trial, OHT recipients were randomized to receive intraoperative haemoadsorption or standard care. Outcomes were vasoactive-inotropic score (VIS), frequency of vasoplegic syndrome (VS) in the first 24 h; post-operative change in procalcitonin (PCT) and C-reactive protein (CRP) levels; intraoperative change in mycophenolic acid (MPA) concentration; frequency of post-operative organ dysfunction, major complications, adverse immunological events and length of in-hospital stay and 1-year survival...
December 19, 2023: ESC Heart Failure
https://read.qxmd.com/read/38073677/right-ventricular-pneumatosis-and-extensive-multi-territory-air-emboli-in-an-intravenous-drug-user-a-case-report
#23
Elizabeth D Paratz, Kudzai Chamunorwa, Marc Lanteri, Amanda Chong-Halliday, Barry Dixon, Andrew I MacIsaac
BACKGROUND: Air emboli are a life-threatening diagnosis, which may form through a range of mechanisms. In this case, we describe the case of extensive multi-territory air emboli in a patient with a history of intravenous drug abuse. CASE SUMMARY: This case describes a 41-year-old male who presented with confusion following fall with long lie. He was diagnosed with hyperkalaemia, renal failure, rhabdomyolysis, and compartment syndrome, and he developed extensive multi-territory air emboli...
September 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/38025122/severe-mitral-stenosis-masquerading-as-cardiogenic-shock-successfully-managed-with-extracorporeal-membrane-oxygenation-and-percutaneous-mitral-commissurotomy-a-case-report
#24
Syed Jalil, Ashraf Ahmed, Mahmoud Abdalla, Mohammed Al-Hijji
BACKGROUND: Rheumatic fever is still a major cause of mitral valve (MV) stenosis in the developing world. Few patients with critical rheumatic MV stenosis can present with acute cardiogenic shock (CS) that requires urgent treatment with circulatory support and definitive valvular repair or replacement. CASE SUMMARY: A 37-year-old gentleman was admitted with heart failure, CS Society for Cardiovascular Angiography and Interventions D, and atrial fibrillation with a rapid ventricular response...
November 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/37984940/angiotensin-ii-in-liver-transplantation-anglt-1-protocol-of-a-randomised-double-blind-placebo-controlled-trial
#25
JOURNAL ARTICLE
Michael P Bokoch, Amy T Tran, Erika L Brinson, Sivan G Marcus, Meghana Reddy, Elizabeth Sun, Garrett R Roll, Manuel Pardo, Scott Fields, Dieter Adelmann, Rishi P Kothari, Matthieu Legrand
INTRODUCTION: Catecholamine vasopressors such as norepinephrine are the standard drugs used to maintain mean arterial pressure during liver transplantation. At high doses, catecholamines may impair organ perfusion. Angiotensin II is a peptide vasoconstrictor that may improve renal perfusion pressure and glomerular filtration rate, a haemodynamic profile that could reduce acute kidney injury. Angiotensin II is approved for vasodilatory shock but has not been rigorously evaluated for treatment of hypotension during liver transplantation...
November 19, 2023: BMJ Open
https://read.qxmd.com/read/37928708/endovascular-management-of-traumatic-renal-artery-inferior-vena-cava-fistula-in-a-covid-patient
#26
Abhiman Baloji, Naveen Kalra, Sreedhara B Chaluvashetty, Sudheer Kumar Devana, Swati Patel
A young teenage boy was referred to this tertiary care centre with a history of penetrating trauma to the flank. He had severe pain abdomen and gross haematuria on presentation. Imaging studies revealed a high flow direct fistulous communication between the renal artery and the inferior vena cava. On further work-up, the patient was also diagnosed with SARS-COV 2. Considering the young age of the patient, haemodynamic stability and the presence of a high flow arteriovenous fistula, endovascular management was opted...
November 2023: BJR Case Reports
https://read.qxmd.com/read/37915916/diastolic-function-in-chronic-kidney-disease
#27
REVIEW
Giovanni de Simone, Costantino Mancusi
Chronic kidney disease (CKD) is characterized by clustered age-independent concentric left ventricular (LV) geometry, geometry-independent systolic dysfunction and age and heart rate-independent diastolic dysfunction. Concentric LV geometry is always associated with echocardiographic markers of abnormal LV relaxation and increased myocardial stiffness, two hallmarks of diastolic dysfunction. Non-haemodynamic mechanisms such as metabolic and electrolyte abnormalities, activation of biological pathways and chronic exposure to cytokine cascade and the myocardial macrophage system also impact myocardial structure and impair the architecture of the myocardial scaffold, producing and increasing reactive fibrosis and altering myocardial distensibility...
November 2023: Clinical Kidney Journal
https://read.qxmd.com/read/37909266/risk-factors-for-sternal-wound-infection-after-open-heart-operations-a-systematic-review-and-meta-analysis
#28
REVIEW
Dongsheng Chen, Jianghe Zhang, Yuting Wang, Weiqian Jiang, Yujian Xu, Chenlu Xiong, Zekun Feng, Yan Han, Youbai Chen
We aimed to quantitatively and systematically elucidate the rationality of the examined variables as independent risk factors for sternal wound infection. We searched databases to screen studies, ascertained the variables to be analysed, extracted the data and applied meta-analysis to each qualified variable. Odds ratios and mean differences were considered to be the effect sizes for binary and continuous variables, respectively. A random-effects model was used for these procedures. The source of heterogeneity was evaluated using a meta-regression...
November 1, 2023: International Wound Journal
https://read.qxmd.com/read/37893422/bio-humoral-and-non-invasive-haemodynamic-correlates-of-renal-venous-flow-patterns-across-the-heart-failure-spectrum
#29
JOURNAL ARTICLE
Lavinia Del Punta, Nicolò De Biase, Matteo Mazzola, Francesco Filidei, Alessio Balletti, Silvia Armenia, Valerio Di Fiore, Simona Buralli, Gian Giacomo Galeotti, Marco De Carlo, Cristina Giannini, Stefano Masi, Nicola Riccardo Pugliese
Background : We evaluated the bio-humoral and non-invasive haemodynamic correlates of renal congestion evaluated by Doppler renal venous flow (RVF) across the heart failure (HF) spectrum, from asymptomatic subjects with cardiovascular risk factors (Stage A) and structural heart disease (Stage B) to patients with clinically overt HF (Stage C). Methods : Ultrasound evaluation, including echocardiography, lung ultrasound and RVF, along with blood and urine sampling, was performed in 304 patients. Results : Continuous RVF was observed in 230 patients (76%), while discontinuous RVF (dRVF) was observed in 74 (24%): 39 patients had pulsatile RVF, 18 had biphasic RVF and 17 had monophasic RVF...
September 24, 2023: Medicina
https://read.qxmd.com/read/37889557/novel-pharmacological-interventions-for-diabetic-kidney-disease
#30
REVIEW
Seng Kiong Tan, Jairo A Pinzon-Cortes, Mark E Cooper
PURPOSE OF REVIEW: The purpose of this review is to summarize the latest evidence on the prevention and progression of diabetic kidney disease (DKD), as well as novel pharmacological interventions from preclinical and early clinical studies with promising findings in the reduction of this condition's burden. RECENT FINDINGS: We will cover the latest evidence on the reduction of proteinuria and kidney function decline in DKD achieved through established renin-angiotensin-aldosterone system (RAAS) system blockade and the more recent addition of SGLT2i, nonsteroidal mineralocorticoid receptor antagonists (MRAs) and GLP1-RA, that combined will most likely integrate the mainstay for current DKD treatment...
January 1, 2024: Current Opinion in Nephrology and Hypertension
https://read.qxmd.com/read/37862447/british-society-of-gastroenterology-best-practice-guidance-outpatient-management-of-cirrhosis-part-2-decompensated-cirrhosis
#31
JOURNAL ARTICLE
Dina Mansour, Steven Masson, Lynsey Corless, Andrew C Douds, Debbie L Shawcross, Jill Johnson, Joanna A Leithead, Michael A Heneghan, Mussarat Nazia Rahim, Dhiraj Tripathi, Valerie Ross, John Hammond, Allison Grapes, Coral Hollywood, Gemma Botterill, Emily Bonner, Mhairi Donnelly, Stuart McPherson, Rebecca West
There are two distinct phases in the natural history of cirrhosis: compensated disease (corresponding to Child Pugh A and early Child Pugh B disease), where the patient may be largely asymptomatic, progressing with increasing portal hypertension and liver dysfunction to decompensated disease (corresponding to Child Pugh late B-C), characterised by the development of overt clinical signs, including jaundice, hepatic encephalopathy (HE), ascites, renal dysfunction and variceal bleeding. The transition from compensated cirrhosis to decompensated cirrhosis (DC) heralds a watershed in the nature and prognosis of the disease...
2023: Frontline Gastroenterology
https://read.qxmd.com/read/37854103/brugada-phenocopy-with-altered-st-segment-elevation-in-pericardial-diffuse-large-b-cell-lymphoma-and-effusive-constrictive-pericarditis-a-case-report
#32
Yohei Ishibashi, Shanshan Zhang, Shuntaro Tamura, Hideki Ishii
BACKGROUND: Cardiac lymphoma is a rare disease. Effusive-constrictive pericarditis can be a characteristic of pericardial involvement in patients with this disease. Conversely, a phenotype with electrocardiogram changes similar to those of Brugada syndrome is called Brugada phenocopy, and these changes improve after treatment. CASE SUMMARY: A 71-year-old man was transported to our hospital with chest pain, hypotension, and ST-segment elevation in V1 and V2 leads during maintenance dialysis for renal failure...
October 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/37821131/potassium-canrenoate-in-brain-dead-organ-donors-a-randomised-controlled-clinical-trial-protocol-canreo-pmo
#33
JOURNAL ARTICLE
Lilia Belarif, Sophie Girerd, Frédéric Jaisser, Xavier Lepage, Ludovic Merckle, Kevin Duarte, Nicolas Girerd, Philippe Guerci
INTRODUCTION: Ischaemia/reperfusion injuries (IRIs) are associated with poorer survival of kidney grafts from expanded criteria donors. Preclinical studies have shown that mineralocorticoid receptor antagonists (MRAs) prevent acute and chronic post-ischaemic renal dysfunction by limiting IRI. However, data concerning the safety of MRAs in brain-dead donor patients are scarce. We seek to investigate the tolerance of MRAs on the haemodynamics in this population. METHODS AND ANALYSIS: CANREO-PMO is a randomised, controlled, single-centre, double-blind study...
October 11, 2023: BMJ Open
https://read.qxmd.com/read/37753645/does-cooled-dialysate-still-have-a-role-in-reducing-intradialytic-stress-implications-of-the-mytemp-trial
#34
JOURNAL ARTICLE
Katherine L Hull, Chris McIntyre, James O Burton
PURPOSE OF REVIEW: There is an excess of cardiovascular morbidity and mortality in the maintenance haemodialysis population. Targeting traditional risk factors (e.g. hypercholesterolaemia) do not improve cardiovascular outcomes. Repeated myocardial stunning during haemodialysis is an important nontraditional risk, resulting in pathological cardiac remodelling and fibrosis. This review explores dialysate cooling as a management strategy to promote haemodynamic stability, reduce myocardial injury, and improve cardiovascular disease outcomes for individuals receiving maintenance haemodialysis...
November 1, 2023: Current Opinion in Nephrology and Hypertension
https://read.qxmd.com/read/37743691/phenotyping-congestion-in-acute-heart-failure-by-renal-flow-and-right-heart-to-pulmonary-circulation-coupling
#35
JOURNAL ARTICLE
Alessandro Vella, Valentina Labate, Gianmarco Carenini, Eleonora Alfonzetti, Valentina Milani, Francesco Bandera, Omar Oliva, Marco Guazzi
AIMS: In acute heart failure (AHF), kidney congestion is basic to treatment and prognosis. Its aetiology is manifold and quite unexplored in details mainly regarding the right heart to pulmonary circulation (Pc) coupling. We investigated the right heart to kidney interrelationship by Doppler renal flow pattern, right atrial dynamics, and right ventricular (RV) function to Pc coupling in AHF. METHODS AND RESULTS: In 119 AHF patients, echocardiographic and renal Doppler data were analysed...
September 24, 2023: ESC Heart Failure
https://read.qxmd.com/read/37728750/patient-phenotype-profiling-using-echocardiography-and-natriuretic-peptides-to-personalise-heart-failure-therapy
#36
REVIEW
Frank L Dini, Erberto Carluccio, Stefano Ghio, Nicola Riccardo Pugliese, Giangiacomo Galeotti, Michele Correale, Matteo Beltrami, Carlo Gabriele Tocchetti, Valentina Mercurio, Stefania Paolillo, Alberto Palazzuoli
Heart failure (HF) is a progressive condition with a clinical picture resulting from reduced cardiac output (CO) and/or elevated left ventricular (LV) filling pressures (LVFP). The original Diamond-Forrester classification, based on haemodynamic data reflecting CO and pulmonary congestion, was introduced to grade severity, manage, and risk stratify advanced HF patients, providing evidence that survival progressively worsened for those classified as warm/dry, cold/dry, warm/wet, and cold/wet. Invasive haemodynamic evaluation in critically ill patients has been replaced by non-invasive haemodynamic phenotype profiling using echocardiography...
March 2024: Heart Failure Reviews
https://read.qxmd.com/read/37723884/maternal-dexamethasone-exposure-does-not-affect-glucose-tolerance-but-alters-renal-haemodynamics-in-f-1-rats-in-a-sex-dependent-manner
#37
JOURNAL ARTICLE
Slava A Malatiali, Narayana Kilarkaje, Maie Al-Bader
INTRODUCTION: Prenatal programming with dexamethasone increases the risk of the development of hyperglycaemia and insulin resistance, leading to diabetes in adulthood. Dexamethasone also causes a decline in renal glomerular filtration in the adult offspring. Sodium-glucose cotransporter-2 (SGLT2) plays a significant role in regulating blood glucose and renal haemodynamics in diabetic patients. However, the role of SGLT2 in dexamethasone-induced programming and the putative sex-dependent effects on the changes named earlier is unknown...
September 18, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37719001/trans-catheter-mitral-valve-in-valve-replacement-in-a-patient-on-venoarterial-extracorporeal-membrane-oxygenation-a-case-report
#38
Jassimran Singh Bainiwal, Jeremy-Ann Ham, Olcay Aksoy
BACKGROUND: Bioprosthetic mitral valves on average have a median durability between 8 and 10 years. After the failure of a bioprosthetic valve, surgical replacement is often indicated. However, the options for those patients at high or prohibitive surgical risks are limited. Here, we describe a case of a successful trans-catheter mitral valve-in-valve (TMViV) replacement on venoarterial extracorporeal membrane oxygenation (VA-ECMO). CASE SUMMARY: We describe a case of a 39-year-old female with a history notable for systemic lupus erythematosus, severe pulmonary arterial hypertension (now mixed pre and post) thought to be secondary to prior substance use, and infective endocarditis complicated by severe mitral stenosis status post-bioprosthetic mitral valve replacement who presented with symptoms of acute hypoxic respiratory failure secondary to severe bioprosthetic mitral valve stenosis...
September 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/37652801/international-registry-on-aortic-balloon-occlusion-in-major-trauma-partial-inflation-does-not-improve-outcomes-in-abdominal-trauma
#39
JOURNAL ARTICLE
Maya Paran, David McGreevy, Tal M Hörer, Mansoor Khan, Mickey Dudkiewicz, Boris Kessel
BACKGROUND: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a method for temporary hemorrhage control used in haemodynamically unwell patients with severe bleeding. In haemodynamically unwell abdominal trauma patients, laparotomy remains the initial procedure of choice. Using REBOA in patients as a bridge to laparotomy is a novel option whose feasibility and efficacy remain unclear. We aimed to assess the clinical outcome in patients with abdominal injury who underwent both REBOA placement and laparotomy...
August 29, 2023: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://read.qxmd.com/read/37633072/changes-in-cardiac-and-vascular-haemodynamics-as-potential-mediators-of-improvements-in-cardiovascular-and-kidney-outcomes-with-empagliflozin-in-type-2-diabetes
#40
RANDOMIZED CONTROLLED TRIAL
Bernhard K Krämer, Sibylle J Hauske, Robert Chilton, Johannes F E Mann, Lars Gullestad, David Fitchett, Michaela Mattheus, Dominik Steubl, Christoph Wanner
AIMS: Evaluate changes in haemodynamic markers as mediators of cardiovascular (CV) and kidney benefits with empagliflozin. METHODS: Post-hoc analysis of EMPA-REG OUTCOME in patients with type 2 diabetes (T2D) and established CV disease receiving empagliflozin (10 and 25 mg) or placebo. Outcomes were CV death, hospitalisation for heart failure [HF], HF death, incident/worsening nephropathy, new onset macroalbuminuria, and the composite of sustained estimated glomerular filtration rate decline ≥40 % from baseline, renal replacement therapy or renal death...
September 2023: Journal of Diabetes and its Complications
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