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https://www.readbyqxmd.com/read/28823112/miniaturized-pulsed-laser-source-for-time-domain-diffuse-optics-routes-to-wearable-devices
#1
Laura Di Sieno, Jan Nissinen, Lauri Hallman, Edoardo Martinenghi, Davide Contini, Antonio Pifferi, Juha Kostamovaara, Alberto Dalla Mora
We validate a miniaturized pulsed laser source for use in time-domain (TD) diffuse optics, following rigorous and shared protocols for performance assessment of this class of devices. This compact source (12×6  mm2) has been previously developed for range finding applications and is able to provide short, high energy (∼100  ps, ∼0.5  nJ) optical pulses at up to 1 MHz repetition rate. Here, we start with a basic level laser characterization with an analysis of suitability of this laser for the diffuse optics application...
August 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28822828/targeted-lowering-of-central-blood-pressure-in-patients-with-hypertension-baseline-recruitment-rationale-and-design-of-a-randomized-controlled-trial-the-low-cbp-study
#2
James E Sharman, Tony Stanton, Christopher M Reid, Anthony Keech, Philip Roberts-Thomson, Simon Stewart, Robert Greenough, Michael Stowasser, Walter P Abhayaratna
BACKGROUND: High blood pressure (BP) is the most common modifiable cause of death from cardiovascular disease. Lowering BP with medication improves patient outcomes, but even in populations with normal upper arm (brachial) BP there remains considerable residual risk for cardiovascular disease and this may be due to persistently elevated central BP. There has never been a trial to determine the value of targeted central BP lowering among patients with hypertension, and this was the aim of this study...
August 16, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28822516/comparison-of-yoga-and-walking-exercise-on-cardiac-time-intervals-as-a-measure-of-cardiac-function-in-elderly-with-increased-pulse-pressure
#3
Satish Gurunathrao Patil, Shankargouda S Patil, Manjunatha R Aithala, Kusal Kanti Das
OBJECTIVE: Arterial aging along with increased blood pressure(BP) has become the major cardiovascular(CV) risk in elderly. The aim of the study was to compare the effects of yoga program and walking-exercise on cardiac function in elderly with increased pulse pressure (PP). METHODS: An open label, parallel-group randomized controlled study design was adopted. Elderly individuals aged ≥60 years with PP≥60mmHg were recruited for the study. Yoga (study) group (n=30) was assigned for yoga training and walking (exercise) group (n=30) for walking with loosening practices for one hour in the morning for 6days in a week for 3 months...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28820411/-importance-of-shear-wave-elastography-of-livers-in-practically-healthy-pregnant-women
#4
E Sariyeva, S Salahova, N Bayramov
Pulse-wave elastography (SWE) that is one of the mostly used methods in the recent years holds important place in assessment of liver fibrosis. However there is no exact information on the results of liver elastography in healthy pregnant women in the world literature. The aim of the study was to investigate theSWE parameters of liver elastography in practically healthy pregnant women. The subject of the research was 50 practically healthy pregnant women within 18-45 years old (mean age 27.7±0.7). The pregnant women with genital and extragenital diseases were not included to the research...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28819303/automated-segmentation-of-light-sheet-fluorescent-imaging-to-characterize-experimental-doxorubicin-induced-cardiac-injury-and-repair
#5
René R Sevag Packard, Kyung In Baek, Tyler Beebe, Nelson Jen, Yichen Ding, Feng Shi, Peng Fei, Bong Jin Kang, Po-Heng Chen, Jonathan Gau, Michael Chen, Jonathan Y Tang, Yu-Huan Shih, Yonghe Ding, Debiao Li, Xiaolei Xu, Tzung K Hsiai
This study sought to develop an automated segmentation approach based on histogram analysis of raw axial images acquired by light-sheet fluorescent imaging (LSFI) to establish rapid reconstruction of the 3-D zebrafish cardiac architecture in response to doxorubicin-induced injury and repair. Input images underwent a 4-step automated image segmentation process consisting of stationary noise removal, histogram equalization, adaptive thresholding, and image fusion followed by 3-D reconstruction. We applied this method to 3-month old zebrafish injected intraperitoneally with doxorubicin followed by LSFI at 3, 30, and 60 days post-injection...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818306/time-harmonic-ultrasound-elastography-of-the-descending-abdominal-aorta-initial-results
#6
Lars-Arne Schaafs, Heiko Tzschätzsch, Markus van der Giet, Alexander Reshetnik, Ingo G Steffen, Bernd Hamm, Jürgen Braun, Ingolf Sack, Thomas Elgeti
Stiffening of central large vessels is considered a key pathophysiologic factor within the cardiovascular system. Current diagnostic parameters such as pulse wave velocity (PWV) indirectly measure aortic stiffness, a hallmark of coronary diseases. The aim of the present study was to perform elastography of the proximal abdominal aorta based on externally induced time-harmonic shear waves. Experiments were performed in 30 healthy volunteers (25 young, 5 old, >50 y) and 5 patients with longstanding hypertension (PWV >10 m/s)...
August 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28816989/disease-duration-of-rheumatoid-arthritis-is-a-predictor-of-vascular-stiffness-a-cross-sectional-study-in-patients-without-known-cardiovascular-comorbidities-a-strobe-compliant-article
#7
Mónica Vázquez-Del Mercado, Eduardo Gomez-Bañuelos, Efrain Chavarria-Avila, Ernesto Cardona-Muñoz, Carlos Ramos-Becerra, Adrián Alanis-Sanchez, David Cardona-Muller, Fernando Grover-Paez, Felipe de J Perez-Vazquez, Rosa-Elena Navarro-Hernandez, Jorge M Valadez-Soto, Adan A Saldaña-Millan, Lorena Gonzalez-Rosas, Gabriel Ramos-Lopez, Marcelo H Petri, Magnus Bäck
The aim of this study was to analyze the impact of disease duration on carotid to femoral pulse wave velocity (cfPWV) in rheumatoid arthritis (RA) patients without either known traditional cardiovascular risk factors or previous comorbidities.Patients with RA diagnosis attending the rheumatology outpatient clinic of Hospital Civil Juan I. Menchaca, Guadalajara, Mexico, were analyzed. A total of 106 RA patients without known traditional cardiovascular risk factors were selected. All subjects were evaluated for RA disease duration, RA disease activity score on 28 joints (DAS28), serum lipids, rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816230/plasma-pcsk9-levels-are-unrelated-to-arterial-stiffness-in-a-community-based-4-8-year-prospective-study
#8
J Han, X Wang, P Ye, R Cao, X Yang, W Xiao, Y Zhang, Y Bai, H Wu
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important circulating serine protease in low-density lipoprotein cholesterol (LDL-C) metabolism. Increased plasma PCSK9 levels lead to increased plasma levels of LDL-C and an increased risk of cardiovascular disease (CVD). LDL-C is positively correlated with arterial stiffness, a surrogate endpoint of CVD. However, whether plasma levels of PCSK9 could influence arterial stiffness is still unclear. Our study examined the relationship between plasma levels of PCSK9 and arterial stiffness (carotid-femoral pulse wave velocity (cf-PWV)) in a community-based population...
August 17, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28814492/influence-of-arterial-stiffness-on-cardiovascular-outcome-in-patients-without-high-blood-pressure
#9
Keishi Ichikawa, Satoru Sakuragi, Takahiro Nishihara, Masahiro Tsuji, Atsushi Mori, Fumi Yokohama, Tadashi Wada, Daiji Hasegawa, Kenji Kawamoto, Machiko Tanakaya, Yusuke Katayama, Hiroshi Ito
OBJECTIVE: Although blood pressure (BP) is a major determinant of arterial stiffness, whether high pulse wave velocity (PWV) adversely influences cardiac parameters and cardiovascular (CV) outcome in patients without high BP remains unclear. METHODS: Outpatients without high BP (n=320), defined as systolic BP ≥140 mm Hg, were enrolled in this retrospective study. At baseline, all patients underwent echocardiography and multidetector CT to determine the coronary artery calcification (CAC) score...
August 16, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28813867/therapeutic-effects-of-anti-gravity-treadmill-alterg-training-on-reflex-hyper-excitability-corticospinal-tract-activities-and-muscle-stiffness-in-children-with-cerebral-palsy
#10
Sh Parvin, A Taghiloo, A Irani, M Mehdi Mirbagheri
We aimed to study therapeutic effects of antigravity treadmill (AlterG) training on reflex hyper-excitability, muscle stiffness, and corticospinal tract (CST) function in children with spastic hemiplegic cerebral palsy (CP). Three children received AlterG training 3 days per week for 8 weeks as experimental group. Each session lasted 45 minutes. One child as control group received typical occupational therapy for the same amount of time. We evaluated hyper-excitability of lower limb muscles by H-reflex response...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28809953/monitoring-health-and-reproductive-status-of-olms-proteus-anguinus-by-ultrasound
#11
Susanne Holtze, Maja Lukač, Ivan Cizelj, Frank Mutschmann, Claudia Anita Szentiks, Dušan Jelić, Robert Hermes, Frank Göritz, Stanton Braude, Thomas Bernd Hildebrandt
The olm (Proteus anguinus) is a troglomorphic, neotenous amphibian with extraordinary life expectancy and unique adaptations that deserve further investigation. A low reproductive rate and habitat decline render it threatened by extinction. Establishing captive populations for maintenance and artificial breeding may one day become crucial to the species. Longitudinal, in-vivo assessment of inner organs is invaluable to our understanding of reproductive physiology, health, and behavior. Using ultrasound, we measured heart rate and assessed health and reproductive status of 13 captive olms at Zagreb Zoo...
2017: PloS One
https://www.readbyqxmd.com/read/28809681/a-prototype-therapy-system-for-transcutaneous-application-of-boiling-histotripsy
#12
Adam D Maxwell, Petr V Yuldashev, Wayne Kreider, Tatiana D Khokhlova, George R Schade, Timothy L Hall, Oleg A Sapozhnikov, Michael R Bailey, Vera A Khokhlova
Boiling histotripsy is a method of focused ultrasound surgery that noninvasively applies millisecond-length pulses with high-amplitude shock fronts to generate liquefied lesions in tissue. Such a technique requires unique outputs compared to a focused ultrasound thermal therapy apparatus, particularly to achieve high in situ pressure levels through intervening tissue. This article describes the design and characterization of a system capable of producing the necessary pressure to transcutaneously administer boiling histotripsy therapy through clinically relevant overlying tissue paths using pulses with duration up to 10 ms...
August 14, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28808067/childhood-socioeconomic-status-and-arterial-stiffness-in-adulthood-the-cardiovascular-risk-in-young-finns-study
#13
Elina Puolakka, Katja Pahkala, Tomi T Laitinen, Costan G Magnussen, Nina Hutri-Kähönen, Mika Kähönen, Terho Lehtimäki, Päivi Tossavainen, Eero Jokinen, Matthew A Sabin, Tomi Laitinen, Marko Elovainio, Laura Pulkki-Råback, Jorma S A Viikari, Olli T Raitakari, Markus Juonala
Increasing evidence supports the importance of socioeconomic factors in the development of atherosclerotic cardiovascular disease. However, the association of childhood socioeconomic status (SES) with arterial stiffness in adulthood has not been reported. Our aim was to determine whether higher childhood family-level SES is associated with lower arterial stiffness in adulthood. The analyses were performed using data gathered within the longitudinal Young Finns Study. The sample comprised 2566 participants who had data concerning family SES at ages 3 to 18 years in 1980 and arterial pulse wave velocity and carotid artery distensibility measured 21 or 27 years later in adulthood...
August 14, 2017: Hypertension
https://www.readbyqxmd.com/read/28807025/changes-in-tibialis-anterior-architecture-affect-the-amplitude-of-surface-electromyograms
#14
Taian M Vieira, Maria Cristina Bisi, Rita Stagni, Alberto Botter
BACKGROUND: Variations in the amplitude of surface electromyograms (EMGs) are typically considered to advance inferences on the timing and degree of muscle activation in different circumstances. Surface EMGs are however affected by factors other than the muscle neural drive. In this study, we use electrical stimulation to investigate whether architectural changes in tibialis anterior (TA), a key muscle for balance and gait, affect the amplitude of surface EMGs. METHODS: Current pulses (500 μs; 2 pps) were applied to the fibular nerve of ten participants, with the ankle at neutral, full dorsi and full plantar flexion positions...
August 14, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28806778/serum-resistin-as-an-independent-marker-of-aortic-stiffness-in-patients-with-coronary-artery-disease
#15
Ji-Hung Wang, Chung-Jen Lee, Chiu-Fen Yang, Yu-Chih Chen, Bang-Gee Hsu
BACKGROUND: Subjects with higher carotid-femoral pulse wave velocity (cfPWV) will be at an increased risk for cardiovascular (CV) events in future. Resistin is an inflammatory mediator and a biomarker of CV diseases. We evaluated the association between serum resistin and aortic stiffness in patients with coronary artery disease (CAD). METHODS: A total of 104 patients with CAD were enrolled in this study. cfPWV was measured using the SphygmoCor system. Patients with cfPWV >10 m/s were defined as the high aortic stiffness group...
2017: PloS One
https://www.readbyqxmd.com/read/28804814/factors-associated-with-cardiovascular-target-organ-damage-in-children-after-renal-transplantation
#16
Bianca Borchert-Mörlins, Daniela Thurn, Bernhard M W Schmidt, Anja K Büscher, Jun Oh, Tanja Kier, Elena Bauer, Sabrina Baig, Nele Kanzelmeyer, Markus J Kemper, Rainer Büscher, Anette Melk
BACKGROUND: Cardiovascular disease is the second-most common cause of death in pediatric renal transplant recipients. The aim of this study was to evaluate subclinical cardiovascular target organ damage defined as the presence of arterio- and atherosclerotic lesions and cardiac remodeling and to analyze contributing risk factors in a large cohort of children after renal transplantation (RT). METHODS: A total of 109 children aged 13.1 ± 3.3 years who had undergone RT at one of three German transplant centers were enrolled in this study...
August 13, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28804255/a-phase-plane-analysis-of-localized-frictional-waves
#17
T Putelat, J H P Dawes, A R Champneys
Sliding frictional interfaces at a range of length scales are observed to generate travelling waves; these are considered relevant, for example, to both earthquake ground surface movements and the performance of mechanical brakes and dampers. We propose an explanation of the origins of these waves through the study of an idealized mechanical model: a thin elastic plate subject to uniform shear stress held in frictional contact with a rigid flat surface. We construct a nonlinear wave equation for the deformation of the plate, and couple it to a spinodal rate-and-state friction law which leads to a mathematically well-posed problem that is capable of capturing many effects not accessible in a Coulomb friction model...
July 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28801878/pulse-waveform-analysis-is-it-ready-for-prime-time
#18
REVIEW
Bernhard Hametner, Siegfried Wassertheurer
PURPOSE OF REVIEW: Arterial pulse waveform analysis has a long tradition but has not pervaded medical routine yet. This review aims to answer the question whether the methodology is ready for prime time use. The current methodological consensus is assessed, existing technologies for waveform measurement and pulse wave analysis are discussed, and further needs for a widespread use are proposed. RECENT FINDINGS: A consensus document on the understanding and analysis of the pulse waveform was published recently...
August 11, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28801846/vascular-function-in-breast-cancer-survivors-on-aromatase-inhibitors-a-pilot-study
#19
Anne Blaes, Heather Beckwith, Natalia Florea, Robert Hebbel, Anna Solovey, David Potter, Douglas Yee, Rachel Vogel, Russell Luepker, Daniel Duprez
PURPOSE: Aromatase inhibitors (AI) have been shown to reduce breast cancer-related mortality in women with estrogen positive (ER+) breast cancer. The use of AIs, however, has been associated with higher rates of hypertension, hyperlipidemia, and cardiovascular (CV) events. METHODS: A cross-sectional study of 25 healthy postmenopausal women and 36 women with curative intent breast cancer on an AI was performed to assess endothelial dysfunction, an indicator of risk for CV events...
August 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28801279/-high-frequency-echocardiography-for-assessment-of-regional-wall-motion-abnormality-and-cardiac-function-in-mice-with-myocardial-infarction
#20
Jing Wang, Wei-Jiang Tan, Xiang Li, Gui-Ping Zhang, Jia-Yuan Huang, Xiao-Hong Chen, Qian Lei, Feng-Hua Yang, Ren Huang
OBJECTIVE: To evaluate the value of high-frequency echocardiography in assessing cardiac structure and function in a mouse model of myocardial infarction. METHODS: Twenty-five C57BL/6 mice were randomly divided into sham-operated group (n=10) and myocardial infarction model group (n=15) established by ligation of the left anterior descending artery. The cardiac structure, regional wall motion and cardiac function of mice were examined with pulsed wave Doppler (PWD), tissue Doppler imaging (TDI), EKV and M-mode echocardiography 3 days before and at 1 week after the operation...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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