keyword
https://read.qxmd.com/read/38534550/active-claw-shaped-dry-electrodes-for-eeg-measurement-in-hair-areas
#21
JOURNAL ARTICLE
Zaihao Wang, Yuhao Ding, Wei Yuan, Hongyu Chen, Wei Chen, Chen Chen
EEG, which can provide brain alteration information via recording the electrical activity of neurons in the cerebral cortex, has been widely used in neurophysiology. However, conventional wet electrodes in EEG monitoring typically suffer from inherent limitations, including the requirement of skin pretreatment, the risk of superficial skin infections, and signal performance deterioration that may occur over time due to the air drying of the conductive gel. Although the emergence of dry electrodes has overcome these shortcomings, their electrode-skin contact impedance is significantly high and unstable, especially in hair-covered areas...
March 13, 2024: Bioengineering
https://read.qxmd.com/read/38534436/morphofunctional-alteration-of-mesenteric-lymph-nodes-in-the-inflammation-of-the-abdominal-cavity
#22
JOURNAL ARTICLE
Serik N Abdreshov, Georgii A Demchenko, Anar N Yeshmukhanbet, Makpal A Yessenova, Sandugash A Mankibaeva, Gulshat K Atanbaeva, Marzhan S Kulbayeva
This paper provides data regarding the ratios of the functional structures of lymph nodes after inflammation in the abdominal organs. Lymph systems, including lymph nodes, function as filters of tissues and tissue fluids and are places of origin and lymphocyte production for normal physiological functions. They display specific morphological and functional responses in reaction to endogenous and exogenous substances. The morphological pattern of the mesenteric lymph node in experimental rat groups reflects a decrease in its immune function due to the processes of inflammation in the abdominal cavity...
March 4, 2024: Biology
https://read.qxmd.com/read/38534363/neonatal-brains-exhibit-higher-neural-reparative-activities-than-adult-brains-in-a-mouse-model-of-ischemic-stroke
#23
JOURNAL ARTICLE
Ryo Nishiyama, Takayuki Nakagomi, Akiko Nakano-Doi, Yoji Kuramoto, Masahiro Tsuji, Shinichi Yoshimura
The neonatal brain is substantially more resistant to various forms of injury than the mature brain. For instance, the prognosis following ischemic stroke is generally poor in the elderly but favorable in neonates. Identifying the cellular and molecular mechanisms underlying reparative activities in the neonatal brain after ischemic injury may provide feasible targets for therapeutic interventions in adults. To this end, we compared the reparative activities in postnatal day 13 and adult (8-12-week-old) mouse brain following middle cerebral artery occlusion...
March 15, 2024: Cells
https://read.qxmd.com/read/38534351/optical-genome-mapping-reveals-genomic-alterations-upon-gene-editing-in-hipscs-implications-for-neural-tissue-differentiation-and-brain-organoid-research
#24
JOURNAL ARTICLE
Lucia Gallego Villarejo, Wanda M Gerding, Lisa Bachmann, Luzie H I Hardt, Stefan Bormann, Huu Phuc Nguyen, Thorsten Müller
Genome editing, notably CRISPR (cluster regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9), has revolutionized genetic engineering allowing for precise targeted modifications. This technique's combination with human induced pluripotent stem cells (hiPSCs) is a particularly valuable tool in cerebral organoid (CO) research. In this study, CRISPR/Cas9-generated fluorescently labeled hiPSCs exhibited no significant morphological or growth rate differences compared with unedited controls...
March 14, 2024: Cells
https://read.qxmd.com/read/38534183/what-factors-can-affect-the-occurrence-of-vertigo-in-patients-after-craniofacial-surgery-in-china
#25
JOURNAL ARTICLE
Sainan Zhang, Jun Zhuang, Wenhong Wu, Lan Huang, Mei Tian, Li Guo, Mengjin Sun, Jintian Hu, Na Liu
Vertigo is a complication of craniomaxillofacial contour plastic surgery characterized by dizziness from hypovolemia in the cerebral hemispheres and brainstem. The authors analyzed the current status and influencing factors of postoperative vertigo in patients who undergo craniomaxillofacial contouring and discussed improvements in nursing strategies. The authors investigated 418 patients admitted to the authors' hospital who underwent craniomaxillofacial contouring between November 2020 and October 2023 and divided them into asymptomatic and symptomatic groups based on syncopal precursors or vertigo...
March 27, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38533990/primary-and-secondary-intracerebral-hemorrhage-in-pregnant-and-nonpregnant-young-adults-by-smash-up-criteria
#26
JOURNAL ARTICLE
Mehriban Sariyeva, Noora Haghighi, Amanda Mitchell, Whitney A Booker, Nils H Petersen, Andrea D Shields, Shivani Ghoshal, Sachin Agarwal, Soojin Park, Jan Claassen, E Sander Connolly, David J Roh, Eliza C Miller
BACKGROUND: Intracerebral hemorrhage (ICH) is a major cause of maternal morbidity, but its pathophysiology is poorly characterized. We investigated characteristics of pregnancy-associated ICH (P-ICH), compared with ICH in similar aged nonpregnant adults of both sexes. METHODS AND RESULTS: We performed a retrospective analysis of 134 adults aged 18 to 44 years admitted to our center with nontraumatic ICH from January 1, 2012, to December 31, 2021. We compared ICH characteristics among 3 groups: those with P-ICH (pregnant or within 12 months of end of pregnancy); nonpregnant women; and men...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533955/deviation-from-personalized-blood-pressure-targets-correlates-with-worse-outcome-after-successful-recanalization
#27
JOURNAL ARTICLE
Zhe Zhang, Yuehua Pu, Lei Yu, Haiwei Bai, Wanying Duan, Xin Liu, Ximing Nie, Zhixuan Wen, Lina Zheng, Xiao Hu, Xinyi Leng, Yuesong Pan, Nils H Petersen, Liping Liu
BACKGROUND: Personalized blood pressure (BP) management for patients with acute ischemic stroke after successful endovascular thrombectomy lacks evidence. We aimed to investigate whether the deviation of BP from cerebral autoregulation limits is associated with worse outcomes. METHODS AND RESULTS: We determined autoregulation by measuring mean velocity index and calculated the percentage of time and the burden (defined as the time-BP area) with BP outside the autoregulatory limits of each subject within 48 hours after endovascular thrombectomy...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533948/gestation-not-lactation-is-to-blame-for-postnatal-vascular-dysfunction-in-offspring-with-maternal-electronic-cigarette-exposure
#28
JOURNAL ARTICLE
Amber Mills, Lainey Shoudis, Mary Cook, Anand Ranpara, Paul D Chantler, I Mark Olfert
No abstract text is available yet for this article.
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533665/introducing-the-concept-of-sanctuary-sites-in-ischemic-stroke
#29
JOURNAL ARTICLE
Tharani Thirugnanachandran, Henry Ma, Geoffrey A Donnan, David C Reutens, Thanh G Phan
BACKGROUND: The topography of arterial territories has been defined using digital maps of supratentorial infarcts. Regions with a high probability of infarction (Pi) exist in the deep compartment due to a paucity of collaterals. However, less attention has been given to regions with a low Pi. METHODS: Using published digital maps, patients with cortical stroke and documented vessel occlusion were included. Infarcts from T2 -weighted magnetic resonance images were segmented and registered onto a standard brain template (Montreal Neurological Institute 152)...
March 27, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38533660/glymphatic-system-impairment-contributes-to-the-formation-of-brain-edema-after-ischemic-stroke
#30
JOURNAL ARTICLE
Juan Zhu, Jiaying Mo, Kewei Liu, Quanfeng Chen, Zheqi Li, Yihua He, Yuan Chang, Chuman Lin, Mingjia Yu, Yikai Xu, Xiangliang Tan, Kaibin Huang, Suyue Pan
BACKGROUND: Blood-brain barrier damage has traditionally been considered to determine the occurrence and development of poststroke brain edema, a devastating and life-threatening complication. However, no treatment strategy targeting blood-brain barrier damage has been proven clinically effective in ameliorating brain edema. METHODS: In mice with stroke models induced by transient middle cerebral artery occlusion (MCAO), the changes in glymphatic system (GS) function impairment were detected by ex vivo fluorescence imaging, 2-photon in vivo imaging, and magnetic resonance imaging within 1 week after MCAO, and the effects of GS impairment and recovery on the formation and resolution of brain edema were evaluated...
March 27, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38533647/physical-activity-mental-activity-and-risk-of-incident-stroke-a-prospective-cohort-study
#31
JOURNAL ARTICLE
Zhi Cao, Jing Zhang, Zuolin Lu, Han Chen, Jiahao Min, Yabing Hou, Xiaohe Wang, Chenjie Xu
BACKGROUND: Cumulative evidence suggests a correlation between physical or mental activity and the risk of stroke. However, the combined impact of these activities on stroke onset remains unexplored. This study identified physical and mental activity patterns using principal component analysis and investigated their associations with risk of incident stroke in the general population. METHODS: Our study was sourced from the UK Biobank cohort between 2006 and 2010...
March 27, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38533641/mechanisms-underpinning-sympathoexcitation-in-hypoxia
#32
JOURNAL ARTICLE
Lydia L Simpson, Mike Stembridge, Christoph Siebenmann, Jonathan P Moore, Justin S Lawley
Sympathoexcitation is a hallmark of hypoxic exposure, occurring acutely, as well as persisting in acclimatised lowland populations and with generational exposure in highland native populations of the Andean and Tibetan plateaus. The mechanisms mediating altitude sympathoexcitation are multifactorial, involving alterations in both peripheral autonomic reflexes and central neural pathways, and are dependent on the duration of exposure. Initially, hypoxia-induced sympathoexcitation appears to be an adaptive response, primarily mediated by regulatory reflex mechanisms concerned with preserving systemic and cerebral tissue O2 delivery and maintaining arterial blood pressure...
March 27, 2024: Journal of Physiology
https://read.qxmd.com/read/38533630/strongly-adhesive-self-healing-hemostatic-hydrogel-for-the-repair-of-traumatic-brain-injury
#33
JOURNAL ARTICLE
Zuoxiang Dong, Jihu Zhao, Jian Xu, Wenshuai Deng, Peng Sun
With wide clinical demands, therapies for traumatic brain injury (TBI) are a major problem in surgical procedures and after major trauma. Due to the difficulty in regeneration of neurons or axons after injury, as well as the inhibition of blood vessel growth by the formation of neural scars, existing treatment measures have limited effectiveness in repairing brain tissue. Herein, the biomultifunctional hydrogels are developed for TBI treatment based on the Schiff base reaction of calcium ion (Ca2+ )-cross-linked oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS)...
March 27, 2024: Biomacromolecules
https://read.qxmd.com/read/38533609/are-central-and-systemic-inflammation-associated-with-fatigue-in-cerebral-small-vessel-disease
#34
JOURNAL ARTICLE
Amy A Jolly, Robin B Brown, Daniel J Tozer, Young T Hong, Tim D Fryer, Franklin Aigbirhio, John O'brien, Hugh S Markus
BACKGROUND: Fatigue is a common symptom in cerebral small vessel disease (SVD), but its pathogenesis is poorly understood. It has been suggested that inflammation may play a role. We determined whether central (neuro) inflammation and peripheral inflammation were associated with fatigue in SVD. METHODS: 36 patients with moderate to severe SVD underwent neuropsychometric testing, combined PET-MRI and blood draw for analysis of inflammatory blood biomarkers. Microglial signal was taken as a proxy for neuroinflammation, assessed with radioligand 11C-PK11195...
March 27, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38533525/towards-an-ai-driven-soft-toy-for-automatically-detecting-and-classifying-infant-toy-interactions-using-optical-force-sensors
#35
JOURNAL ARTICLE
Rithwik Udayagiri, Jessica Yin, Xinyao Cai, William Townsend, Varun Trivedi, Rohan Shende, O Francis Sowande, Laura A Prosser, James H Pikul, Michelle J Johnson
Introduction: It is crucial to identify neurodevelopmental disorders in infants early on for timely intervention to improve their long-term outcomes. Combining natural play with quantitative measurements of developmental milestones can be an effective way to swiftly and efficiently detect infants who are at risk of neurodevelopmental delays. Clinical studies have established differences in toy interaction behaviors between full-term infants and pre-term infants who are at risk for cerebral palsy and other developmental disorders...
2024: Frontiers in Robotics and AI
https://read.qxmd.com/read/38533418/association-between-spo-2-and-the-risk-of-death-in-elderly-t2dm-patients-with-cerebral-infarction-a-retrospective-cohort-study
#36
JOURNAL ARTICLE
Shuo Zhang, Jiaqi Ji, Siqi Gao, Shu Yang, Zeyi Song, Jianmin Li, Junjie Liu
OBJECTIVE: This study aimed to evaluate the SpO2 (transcutaneous oxygen saturation) -mortality link in elderly T2DM (diabetes mellitus type 2) patients with cerebral infarction and identify their optimal SpO2 range. METHODS: In this investigation, we employed a comprehensive approach. Initially, we screened the MIMIC-IV database, identifying elderly T2DM patients with cerebral infarction, utilizing specific ICD-9 and ICD-10 codes. We then harnessed the power of restricted cubic splines to craft a visual representation of the correlation between SpO2 and 1-year mortality...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38533325/eosinophilic-granulomatosis-with-polyangiitis-presenting-with-purpura-mononeuritis-multiplex-and-cerebral-infarction
#37
Aswinishree Bagavandoss, Jency Kurian, Samson O Oyibo, Olugbenro O Akintade
We present a case of a 52-year-old woman who had transient speech impediment and progressive numbness, weakness, and a purpuric rash affecting her limbs, with severe joint pains. Because she had a chest infection two weeks prior, her clinical presentation gave rise to a suspicion of post-infective vasculitis or post-infective polyneuritis. Further investigation proved this to be eosinophilic granulomatosis with polyangiitis (EGPA) presenting with purpura, mononeuritis multiplex, and cerebral infarction. Treatment with glucocorticoids and cyclophosphamide led to rapid remission...
March 2024: Curēus
https://read.qxmd.com/read/38533257/naodesheng-decoction-regulating-vascular-function-via-g-protein-coupled-receptors-network-analysis-and-experimental-investigations
#38
JOURNAL ARTICLE
Shuhan Chen, Ziran Niu, Yanjia Shen, Wendan Lu, Jiaying Zhao, Huilin Yang, Minmin Guo, Li Zhang, Ruifang Zheng, Guanhua Du, Li Li
Introduction: Ischemic stroke (IS) is a detrimental neurological disease with limited treatment options. Recanalization of blocked blood vessels and restoring blood supply to ischemic brain tissue are crucial for post-stroke rehabilitation. The decoction Naodesheng (NDS) composed of five Chinese botanical drugs, including Panax notoginseng (Burk.) F. H. Chen, Ligusticum chuanxiong Hort., Carthamus tinctorius L., Pueraria lobata (Willd.) Ohwi, and Crataegus pinnatifida Bge., is a blood-activating and stasis-removing herbal medicine commonly used for the clinical treatment of cerebrovascular diseases in China...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533169/from-pansinusitis-to-cerebritis-due-to-eikenella-corrodens
#39
Adriana América Silva, Inês Zão, João A Louro, Eduarda Pereira, Elisabete Monteiro
Meningitis is a rare but possible complication of sinusitis. We present a case of a 21-year-old woman with a history of fever, headache and nasal obstruction who presented at the emergency department with psychomotor agitation. Orotracheal intubation and invasive mechanical ventilation were given to protect airway. Blood analysis showed leukocytosis and elevated C-reactive protein. Cerebral and maxillofacial computed tomography (CT) demonstrated pansinusitis with gas foci more prominent in the left frontal sinus with an area of ​​bone rarefaction on the posterior wall with possible communication with the cranial cavity...
February 2024: Curēus
https://read.qxmd.com/read/38533149/a-case-report-of-pediatric-rehabilitation-for-hypoxic-ischemic-encephalopathy-associated-with-global-developmental-delay
#40
Prajyot Ankar, H V Sharath, Nitika Chavan
Hypoxic ischemic encephalopathy (HIE) is a critical condition affecting neonates due to oxygen deprivation and insufficient flow of blood to the brain. It is associated with high neonatal mortality and the risk of developmental psychomotor disorders, including cerebral palsy. The global epidemiology of HIE reveals significant disparities, with more advanced healthcare systems reporting lower incidence rates. The aim of the study is to contribute to the understanding of effective rehabilitation strategies for children with HIE and global developmental delay (GDD), with the goal of improving outcomes and quality of life for these individuals...
February 2024: Curēus
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