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https://www.readbyqxmd.com/read/28453871/elevated-cerebrospinal-fluid-tumor-necrosis-factor-is-associated-with-acute-and-long-term-neurocognitive-impairment-in-cerebral-malaria
#1
Estela Shabani, Benson J Ouma, Richard Idro, Paul Bangirana, Robert O Opoka, Gregory S Park, Andrea L Conroy, Chandy C John
Systemic tumor necrosis factor-α (TNF-α) may contribute to the pathogenesis of cerebral malaria (CM) by promoting endothelial activation and parasite sequestration. However less is known about the role of central nervous system (CNS) TNF-α in CM. We assessed plasma (n=249) and cerebrospinal fluid (CSF) (n=167) TNF-α levels in Ugandan children with CM, plasma TNF-α in Ugandan community control children (n=198), and CSF TNF-α in North American control children who had recovered from leukemia (n=13). Plasma and CSF TNF-α were measured by magnetic bead assay...
April 28, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28453486/cognitive-deficits-after-cerebral-ischemia-and-underlying-dysfunctional-plasticity-potential-targets-for-recovery-of-cognition
#2
Holly M Stradecki-Cohan, Charles H Cohan, Ami P Raval, Kunjan R Dave, Diego Reginensi, Rolando A Gittens, Mehdi Youbi, Miguel A Perez-Pinzon
Cerebral ischemia affects millions of people worldwide and survivors suffer from long-term functional and cognitive deficits. While stroke and cardiac arrest are typically considered when discussing ischemic brain injuries, there is much evidence that smaller ischemic insults underlie neurodegenerative diseases, including Alzheimer's disease. The "regenerative" capacity of the brain relies on several aspects of plasticity that are crucial for normal functioning; less affected brain areas may take over function previously performed by irreversibly damaged tissue...
April 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28453476/reduced-cerebral-blood-flow-in-mild-cognitive-impairment-assessed-using-phase-contrast-mri
#3
Reyes García de Eulate, Irene Goñi, Alvaro Galiano, Marta Vidorreta, Miriam Recio, Mario Riverol, José L Zubieta, María A Fernández-Seara
There is increasing evidence of a vascular contribution to Alzheimer's disease (AD). In some cases, prior work suggests that chronic brain hypoperfusion could play a prime pathogenic role contributing to the accumulation of amyloid-β,while other studies favor the hypothesis that vascular dysfunction and amyloid pathology are independent, although synergistic, mechanisms contributing to cognitive impairment. Vascular dysfunction can be evaluated by assessing cerebral blood flow impairment. Phase contrast velocity mapping by MRI offers a non-invasive means of quantifying the total inflow of blood to the brain...
April 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28453332/long-term-intermittent-exposure-to-high-altitude-elevates-asymmetric-dimethylarginine-in-first-exposed-young-adults
#4
Nicole Lüneburg, Patricia Siques, Julio Brito, Juan José De La Cruz, Fabiola León-Velarde, Juliane Hannemann, Cristian Ibanez, Rainer H Böger
Lüneburg, Nicole, Patricia Siques, Julio Brito, Juan José De La Cruz, Fabiola León-Velarde, Juliane Hannemann, Cristian Ibanez, and Rainer Böger. Long-term intermittent exposure to high altitude elevates asymmetric dimethylarginine in first exposed young adults. High Alt Med Biol 00:000-000, 2017.-Hypoxia-induced dysregulation of pulmonary and cerebral circulation may be related to an impaired nitric oxide (NO) pathway. We investigated the effect of chronic intermittent hypobaric hypoxia (CIH) on metabolites of the NO pathway...
April 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28449483/epicardial-left-atrial-appendage-closure-comparison-of-surgical-techniques-in-an-ex-vivo-model
#5
Nikolas Mirow, Sebastian Vogt, Marc Irqsusi, Rainer Moosdorf, Andreas Kirschbaum
BACKGROUND: Formation of clots in the left atrial appendage (LAA) may lead to embolism and consecutive cerebral stroke. This risk is reduced by closure and resection. To address the efficacy of surgical LAA closure, resilience to pneumatic pressure was studied. Different surgical techniques were compared in an experimental model. METHODS: From freshly slaughtered pigs cardiopulmonary preparations were taken. The left atrium was clamped airtight and the LAA was cannulated...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449405/the-impact-of-lesion-location-on-dysphagia-incidence-pattern-and-complications-in-acute-stroke-part-2-oropharyngeal-residue-swallow-and-cough-response-and-pneumonia
#6
S Suntrup-Krueger, A Kemmling, T Warnecke, C Hamacher, S Oelenberg, T Niederstadt, W Heindel, H Wiendl, R Dziewas
BACKGROUND AND PURPOSE: Dysphagia is a well-known complication of acute stroke. Given the complexity of cerebral swallowing control it is still difficult to predict which patients are likely to develop swallowing dysfunction based on their neuroimaging. In Part 2 of a comprehensive voxel-based imaging study, whether the location of a stroke lesion can be correlated with further dysfunctional swallowing patterns, pulmonary protective reflexes and pneumonia was evaluated. METHODS: In all, 200 acute stroke cases were investigated applying flexible endoscopic evaluation of swallowing within 96 h from admission...
April 27, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28449277/expertise-shapes-domain-specific-functional-cerebral-asymmetry-during-mental-imagery-the-case-of-culinary-arts-and-music
#7
Moustafa Bensafi, Arnaud Fournel, Pauline Joussain, Johan Poncelet, Lauranne Przybylski
Mental imagery in experts has been documented in visual arts, music and dance. Here, we examined this issue in an understudied art domain, namely culinary arts. Previous research investigating mental imagery in experts has reported either a stronger involvement of the right hemisphere or bilateral brain activation. The first aim of our study was to examine whether culinary arts also recruit such a hemispheric pattern specifically during odor mental imagery. In a second aim, we investigated whether expertise effects observed in a given sensory domain transfer to another modality...
April 27, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28449234/magnetic-resonance-imaging-and-computed-tomographic-characteristics-of-a-glioma-causing-calvarial-erosion-in-a-dog
#8
Alfredo Recio, Cristian de la Fuente, Martí Pumarola, Yvonne Espada, Sònia Añor
An 8-year-old female Boxer was examined for acute onset of seizures. On magnetic resonance imaging (MRI), an intra-axial mass with imaging features consistent with glioma was observed in the right cerebral hemisphere. A defect in the temporal bone adjacent to the mass was observed. Postmortem computed tomography (CT) confirmed temporal bone osteolysis and necropsy demonstrated a glioblastoma with associated calvarial erosion. Although occasionally described in human medicine, to our knowledge, this is the first description of a brain glioma causing calvarial erosion in a dog...
April 27, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28449077/executive-network-activation-is-linked-to-walking-speed-in-older-adults-functional-mri-and-tcd-ultrasound-evidence-from-the-mobilize-boston-study
#9
Azizah J Jor'dan, Victoria N Poole, Ikechukwu Iloputaife, William Milberg, Brad Manor, Michael Esterman, Lewis A Lipsitz
Background: Changes in cerebral blood flow velocity (CBF) in response to a cognitive task (task-related ΔCBF) have been shown by Transcranial Doppler ultrasonography (TCD) to be reduced in slow walkers. However, it is unknown whether reduced task-related ΔCBF is associated with reduced neural activity in specific brain regions, as measured by blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI). Methods: We assessed the regional changes in neural activity associated with reduced middle cerebral artery (MCA) task-related ΔCBF to an executive task and slow walking speed in 67 community-dwelling older adults from the MOBILIZE Boston Study...
April 26, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28448965/neuroprotective-treatments-after-perinatal-hypoxic-ischemic-brain-injury-evaluated-with-magnetic-resonance-spectroscopy
#10
Hester Rijkje Berger, Eva Brekke, Marius Widerøe, Tora Sund Morken
Perinatal hypoxic-ischemic brain injury is a major health problem. Adjuvant treatments that improve the neuroprotective effect of the current treatment, therapeutic hypothermia, are urgently needed. The growing knowledge about the complex pathophysiology of hypoxia-ischemia (HI) has led to the discovery of several important targets for neuroprotection. Early interventions should focus on the preservation of energy metabolism, the reduction of glutamate excitotoxicity and oxidative stress, the maintenance of calcium homeostasis, and the prevention of apoptosis...
April 28, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28448898/kinematic-gait-pattern-in-children-with-cerebral-palsy-and-leg-length-discrepancy-effects-of-an-extra-sole
#11
Meta N Eek, Roland Zügner, Ingibjörg Stefansdottir, Roy Tranberg
The gait pattern in children with cerebral palsy (CP) often differs from normal, with slow velocity, problem with foot clearance and increased stress on joints. Several factors, such as muscle tone, impaired motor control, muscle contractures, skeletal deformities and leg length discrepancy affect gait. Leg length discrepancy can be treated surgically or with elevation of the shoe on the short leg. The purpose of this study was to examine whether compensating for leg length discrepancy, with elevation of the sole, leads to a change in movement pattern during walking in children with spastic CP...
April 17, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28448579/il-33-receptor-st2-regulates-the-cognitive-impairments-associated-with-experimental-cerebral-malaria
#12
Flora Reverchon, Stéphane Mortaud, Maëliss Sivoyon, Isabelle Maillet, Anthony Laugeray, Jennifer Palomo, Céline Montécot, Améziane Herzine, Sandra Meme, William Meme, François Erard, Bernhard Ryffel, Arnaud Menuet, Valérie F J Quesniaux
Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors. The murine model of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA)-infection reproduces several of these features. We reported recently increased levels of IL-33 protein in brain undergoing ECM and the involvement of IL-33/ST2 pathway in ECM development. Here we show that PbA-infection induced early short term and spatial memory defects, prior to blood brain barrier (BBB) disruption, in wild-type mice, while ST2-deficient mice did not develop cognitive defects...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28448573/correction-kidney-dysfunction-and-cerebral-microbleeds-in-neurologically-healthy-adults
#13
Sang Hyuck Kim, Dong Wook Shin, Jae Moon Yun, Ji Eun Lee, Jae-Sung Lim, Be Long Cho, Hyung-Min Kwon, Jin-Ho Park
[This corrects the article DOI: 10.1371/journal.pone.0172210.].
2017: PloS One
https://www.readbyqxmd.com/read/28448521/immunization-with-toxoplasma-gondii-peroxiredoxin-1-induces-protective-immunity-against-toxoplasmosis-in-mice
#14
Ragab M Fereig, Yasuhiro Kuroda, Mohamad Alaa Terkawi, Motamed Elsayed Mahmoud, Yoshifumi Nishikawa
To develop a vaccine against Toxoplasma gondii, a vaccine antigen with immune-stimulating activity is required. In the present study, we investigated the immunogenicity and prophylactic potential of T. gondii peroxiredoxin 1 (TgPrx1). The TgPrx1 was detected in the ascitic fluid of mice 6 days postinfection, while specific antibody levels were low in the sera of chronically infected mice. Treatment of murine peritoneal macrophages with recombinant TgPrx1 triggered IL-12p40 and IL-6 production, but not IL-10 production...
2017: PloS One
https://www.readbyqxmd.com/read/28448515/chronic-cocaine-induces-hif-vegf-pathway-activation-along-with-angiogenesis-in-the-brain
#15
Wei Yin, Kevin Clare, Qiujia Zhang, Nora D Volkow, Congwu Du
Cocaine induces vasoconstriction in cerebral vessels, which with repeated use can result in transient ischemic attacks and cerebral strokes. However, the neuroadaptations that follow cocaine's vasoconstricting effects are not well understood. Here, we investigated the effects of chronic cocaine exposure (2 and 4 weeks) on markers of vascular function and morphology in the rat brain. For this purpose we measured nitric oxide (NO) concentration in plasma, brain neuronal nitric oxide synthase (nNOS or NOS1), HIF-1α, and VEGF expression in different brain regions, i...
2017: PloS One
https://www.readbyqxmd.com/read/28448448/in-vitro-ex-vivo-and-in-vivo-techniques-to-study-neuronal-migration-in-the-developing-cerebral-cortex
#16
REVIEW
Roberta Azzarelli, Roberto Oleari, Antonella Lettieri, Valentina Andre', Anna Cariboni
Neuronal migration is a fundamental biological process that underlies proper brain development and neuronal circuit formation. In the developing cerebral cortex, distinct neuronal populations, producing excitatory, inhibitory and modulatory neurotransmitters, are generated in different germinative areas and migrate along various routes to reach their final positions within the cortex. Different technical approaches and experimental models have been adopted to study the mechanisms regulating neuronal migration in the cortex...
April 27, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28448430/family-dog-assisted-adapted-physical-activity-a-case-study
#17
Amanda Tepfer, Samantha Ross, Megan MacDonald, Monique A R Udell, Craig Ruaux, Wendy Baltzer
Purpose: The aim of this case study was to examine the individual effects of an adapted physical activity, animal-assisted intervention (APA-AAI) with the family dog on motor skills, physical activity, and quality of life of a child with cerebral palsy (CP). Method: This study used an A-B-A single-subject design. The assessment phase (phase A) occurred pre- and post-intervention. This consisted of standardized assessments of motor skills, quality of life questionnaires, physical activity (measured using the GT3X+ accelerometer) and the human-animal bond...
April 27, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28448422/iterative-reconstruction-designed-for-brain-ct-a-correlative-study-with-filtered-back-projection-for-the-diagnosis-of-acute-ischemic-stroke
#18
Yuji Iyama, Takeshi Nakaura, Seitaro Oda, Masafumi Kidoh, Daisuke Utsunomiya, Morikatsu Yoshida, Hideaki Yuki, Kenichiro Hirata, Yoshinori Funama, Kazunori Harada, Kazuo Awai, Toshinori Hirai, Yasuyuki Yamashita
OBJECTIVES: The objective of this study is to evaluate the usefulness of iterative model reconstruction designed for brain computed tomography (CT) (IMR-Neuro) for the diagnosis of acute ischemic stroke. METHODS: This retrospective study included 20 patients with acute middle cerebral artery infarction who have undergone brain CT and 20 nonstroke patients (control). We reconstructed axial images with filtered back projection (FBP) and IMR-Neuro (slice thickness, 1 and 5 mm)...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28447863/lysophosphatidic-acid-and-amitriptyline-signal-through-lpa1r-to-reduce-p-glycoprotein-transport-at-the-blood-brain-barrier
#19
David B Banks, Gary Ny Chan, Rebecca A Evans, David S Miller, Ronald E Cannon
The blood-brain barrier is a microvascular network that (1) provides neuroprotection from metabolic and environmental toxins and (2) limits the delivery of therapeutics to the central nervous system (CNS). The ATP-binding cassette transporter P-glycoprotein contributes to the latter by actively pumping clinical substrates back into circulation before they can reach the brain parenchyma. Targeting P-glycoprotein has proven effective in increasing the delivery of therapeutics to their cerebral targets. We provide a novel mechanism to achieve this end in functioning, intact rat brain capillaries, whereby the bioactive phospholipid lysophosphatidic acid (LPA) and tricyclic antidepressant (TCA) amitriptyline reduce basal P-glycoprotein transport activity through a distinct lysophosphatidic acid 1 receptor-mediated signaling cascade that requires G-protein coupling, Src kinase, and ERK 1/2...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28447507/akinetic-mutism-reversibility-after-l-dopa-therapy-in-unilateral-left-anterior-cerebral-artery-infarction
#20
Guery Deborah, Elodie Ong, Norbert Nighoghossian
No abstract text is available yet for this article.
April 27, 2017: Neurocase
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