keyword
MENU ▼
Read by QxMD icon Read
search

Cerebritis

keyword
https://www.readbyqxmd.com/read/29041032/assessing-the-structural-footprint-of-minimally-invasive-brain-cannulation-on-cerebral-white-matter-a-cadaveric-model
#1
Sananthan Sivakanthan, Pawel G Ochalski, Claudiu Schirda, Johnathan A Engh
No abstract text is available yet for this article.
October 17, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29040978/hydrogen-rich-saline-attenuates-brain-injury-induced-by-cardiopulmonary-bypass-and-inhibits-microvascular-endothelial-cell-apoptosis-via-the-pi3k-akt-gsk3%C3%AE-signaling-pathway-in-rats
#2
Keyan Chen, Nan Wang, Yugang Diao, Wanwei Dong, YingJie Sun, Lidan Liu, Xiuying Wu
BACKGROUND/AIMS: Cardiopulmonary bypass (CPB) is prone to inducing brain injury during open heart surgery. A hydrogen-rich solution (HRS) can prevent oxidation and apoptosis, and inhibit inflammation. This study investigated effects of HRS on brain injury induced by CPB and regulatory mechanisms of the PI3K/Akt/GSK3β signaling pathway. METHODS: A rat CPB model and an in vitro cell hypoxia model were established. After HRS treatment, Rat behavior was measured using neurological deficit score; Evans blue (EB) was used to assess permeability of the blood-brain barrier (BBB); HE staining was used to observe pathological changes; Inflammatory factors and brain injury markers were detected by ELISA; the PI3K/Akt/GSK3β pathway-related proteins and apoptosis were assessed by western blot, immunohistochemistry and qRT -PCR analyses of brain tissue and neurons...
October 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29040971/characteristics-and-outcomes-of-vertebrobasilar-artery-dissection-with-accompanied-atherosclerosis
#3
Chun Chien, Feng-Chi Chang, Hui-Chi Huang, Jui-Yao Tsai, Chih-Ping Chung
BACKGROUND: With the popularity of MRI use, vertebrobasilar artery dissection (VBD) has been found more frequently in patients with posterior circulation ischemic stroke (PCS). The relationship between VBD and atherosclerosis is unknown. The present study aimed to prove the hypothesis that PCS with pure VBD (p-VBD) and with VBD and accompanied cervical or cerebral artery atherosclerosis (a-VBD) have distinct manifestations. METHODS: Patients with VBD-related PCS who were prospectively enrolled in the Taipei Veterans General Hospital Stroke Registry between January 1, 2010 and August 31, 2014 were recruited for the present study...
October 17, 2017: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/29040883/veno-arterial-extracorporeal-membrane-oxygenation-va-ecmo-for-emergency-cardiac-support
#4
Terri Sun, Andrew Guy, Amandeep Sidhu, Gordon Finlayson, Brian Grunau, Lillian Ding, Saida Harle, Leith Dewar, Richard Cook, Hussein D Kanji
PURPOSE: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) may provide benefit to patients in refractory cardiac arrest and cardiogenic shock. We aim to summarize our center's 6-year experience with resuscitative VA-ECMO. MATERIALS AND METHODS: A retrospective medical record review (April 2009 to 2015) was performed on consecutive non-cardiotomy patients who were managed with VA-ECMO due to refractory in- or out-of-hospital cardiac (IHCA/OHCA) arrest (E-CPR) or refractory cardiogenic shock (E-CS) with or without preceding cardiac arrest...
October 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29040874/surface-functionalized-exosomes-as-targeted-drug-delivery-vehicles-for-cerebral-ischemia-therapy
#5
Tian Tian, Hui-Xin Zhang, Chun-Peng He, Song Fan, Yan-Liang Zhu, Cui Qi, Ning-Ping Huang, Zhong-Dang Xiao, Zu-Hong Lu, Bakhos A Tannous, Jun Gao
The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the treatment of cerebral ischemia given their unique properties, including low immunogenicity, innate stability, high delivery efficiency, and ability to cross the blood-brain barrier (BBB). However, exosome insufficient targeting capability limits their clinical applications. In this study, the c(RGDyK) peptide has been conjugated to the exosome surface by an easy, rapid, and bio-orthogonal chemistry...
October 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/29040698/clinical-outcome-after-endoscopic-endonasal-resection-of-tuberculum-sella-meningiomas
#6
Khaled Elshazly, Varun R Kshettry, Christopher J Farrell, Gurston Nyquist, Marc Rosen, James J Evans
BACKGROUND: In select cases, the endoscopic endonasal approach (EEA) has distinct advantages for resection of tuberculum sella meningiomas (TSM). OBJECTIVE: To report the extent of resection (EOR), complication rates, and outcomes in a large series of TSM treated by the EEA. METHODS: Twenty-five consecutive TSM cases treated by EEA from 2008 to 2016 were retrospectively reviewed. Patient history, imaging, volumetric EOR, complications, and outcomes are presented...
October 10, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29040166/measurement-of-retinal-vessels-as-a-biomarker-of-cerebrovascular-ageing-in-older-hiv-positive-men-compared-to-controls
#7
Lewis Haddow, Rosanna Laverick, Irene Leung, Frank Post, Jaime Vera, Richard Gilson, Ian Williams, Marta Boffito, Caroline Sabin, Alan Winston, Tunde Peto
BACKGROUND: To compare retinal vascular measurements, biomarkers of cerebral small vessel disease (SVD), in HIV positive men aged 50 years and above with similarly-aged HIV negative men and younger HIV positive men. METHODS: We recruited white, non-diabetic men to a cross-sectional substudy of a larger cohort including three demographically-matched groups. Optic disc centred 45° colour fundus photographs were used to calculate central retinal arterial and venous calibre and the arterial-venous ratio (AVR)...
October 14, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29036975/-predictive-value-of-serial-platelet-function-testing-on-outcome-in-patients-undergoing-complex-percutaneous-coronary-intervention
#8
M M Li, Q Li, X J Ren, X P Yu, J Q He, Y C Gao, C Y Wu, Y W Luo, Y C Zhang, F Chen, X L Zhang
Objective: To observe the predictive value of serial platelet function testing (PFT) on outcome in patients undergoing complex percutaneous coronary intervention (PCI). Methods: Six hundred and two consecutive patients undergoing complex PCI in Anzhen hospital were enrolled during October 2011 to June 2012.Adenosine diphosphate(ADP)-induced platelet aggregation was measured by light transmission aggregometry on the first, sixth and twelfth month after PCI and the mean value was calculated.The cut-off value of high on-treatment platelet reactivity (HTPR) was defined as 40%...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036956/-the-diagnostic-value-of-neuron-specific-enolase-central-nervous-system-specific-protein-and-interleukin-6-in-sepsis-associated-encephalopathy
#9
Q Feng, L Wu, Y H Ai, S Y Deng, M L Ai, L Huang, Z Y Liu, L N Zhang
Objective: To investigate the diagnostic value of neuron-specific enolase(NSE), central nervous system specific protein(S100β), interleukin-6(IL-6) in sepsis-associated encephalopathy(SAE). Methods: Clinical data of patients admitted to ICU and diagnosed with sepsis were collected from January 2015 to June 2016 in Xiangya Hospital, Central South University. SAE was defined as cerebral dysfunction in the presence of sepsis that also fulfilled the exclusion criteria. The acute physiology and chronic health score (APACHE Ⅱ), sequential organ failure assessment (SOFA), NSE, S100β, IL-6, ICU stay time and 28-day mortality were compared between the two groups...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29036908/propofol-induces-apoptosis-of-neurons-but-not-astrocytes-oligodendrocytes-or-neural-stem-cells-in-the-neonatal-mouse-hippocampus
#10
Yasheng Yan, Shigang Qiao, Chika Kikuchi, Ivan Zaja, Sarah Logan, Congshan Jiang, Thiago Arzua, Xiaowen Bai
It has been shown that propofol can induce widespread apoptosis in neonatal mouse brains followed by long-term cognitive dysfunction. However, selective brain area and cell vulnerability to propofol remains unknown. This study was aimed to dissect toxic effect of propofol on multiple brain cells, including neurons, astrocytes, oligodendrocytes, and neural stem cells (NSCs). Seven-day-old mice were intraperitoneally administrated propofol or intralipid as a vehicle control for 6 hours. To identify vulnerable cells undergoing apoptosis following propofol exposure, brain sagittal sections were co-stained with antibodies against an apoptosis marker along with neuron, astrocyte, oligodendrocyte, or NSC markers using immunofluorescence staining...
October 14, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29036822/cortical-cerebral-microinfarcts-on-3-tesla-mri-in-patients-with-vascular-cognitive-impairment
#11
Doeschka A Ferro, Susanne J van Veluw, Huiberdina L Koek, Lieza G Exalto, Geert Jan Biessels
BACKGROUND: Cerebral microinfarcts (CMIs) are small ischemic lesions that are a common neuropathological finding in patients with stroke or dementia. CMIs in the cortex can now be detected in vivo on 3 Tesla MRI. OBJECTIVE: To determine the occurrence of CMIs and associated clinical features in patients with possible vascular cognitive impairment (VCI). METHOD: 182 memory-clinic patients (mean age 71.4±10.6, 55% male) with vascular injury on brain MRI (i...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036811/sildenafil-improves-vascular-and-metabolic-function-in-patients-with-alzheimer-s-disease
#12
Min Sheng, Hanzhang Lu, Peiying Liu, Yang Li, Harshan Ravi, Shin-Lei Peng, Ramon Diaz-Arrastia, Michael D Devous, Kyle B Womack
BACKGROUND: Alzheimer's disease (AD) is the leading cause of degenerative dementia in the aging population. Patients with AD have alterations in cerebral hemodynamic function including reduced cerebral blood flow (CBF) and cerebral metabolic rate. Therefore, improved cerebrovascular function may be an attractive goal for pharmaceutical intervention in AD. OBJECTIVE: We wished to observe the acute effects of sildenafil on cerebrovascular function and brain metabolism in patients with AD...
October 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036757/a-case-of-medullary-infarction-presented-initial-symptoms-similar-to-meniere-s-disease
#13
Jang Hee Park, Dong Hyun Kim, Jae Moon Sung, Chang Woo Kim
Fluctuating hearing loss and vertigo are the typical presentations of Meniere's disease. However, it is unusual that fluctuating hearing loss and vertigo are caused by vertebral artery occlusion or cerebral infarction. Here, we described the case of a 54-year-old male patient with hypertension and diabetes mellitus who presented with fluctuating hearing loss in his left ear and severe whirling-type dizziness without associated neurological signs or symptoms. Temporal magnetic resonance imaging (MRI) was normal...
October 17, 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29036623/predictors-of-mortality-in-high-risk-patients-with-qt-prolongation-in-a-community-hospital
#14
Charlotte Gibbs, Jacob Thalamus, Kristian Heldal, Øystein Lunde Holla, Kristina H Haugaa, Jan Hysing
Aims: To determine predictors of mortality in patients with corrected QT interval (QTc) ≥ 500 ms in a community hospital. Methods and results: In this retrospective observational study, we searched the electrocardiogram (ECG) database at Telemark Hospital Trust, Norway, from January 2004 to December 2014. Medication, electrolyte abnormalities, and medical conditions known to prolong the QT interval were recorded. From the medical records, we assessed whether the prolonged QTc was noted by the health care providers...
October 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036615/monitoring-of-cerebral-oximetry-during-head-up-tilt-test-in-adults-with-history-of-syncope-and-orthostatic-intolerance
#15
E Bachus, H Holm, V Hamrefors, O Melander, R Sutton, M Magnusson, A Fedorowski
Aims: We applied near-infrared-spectroscopy (NIRS) to measure absolute frontal cerebral tissue oxygen saturation (SctO2) during head-up tilt test (HUT) in patients investigated for unexplained syncope. Methods and results: Synchronized non-invasive beat-to-beat haemodynamic monitoring, ECG, SctO2 (NIRS; normal range: 60-80%), and peripheral oxygen saturation (left hand, SpO2) were applied during HUT in a random sample of patients with unexplained syncope. Tracings of 54 patients (mean-age: 55 ± 19 years, 39% male) with negative HUT, vasovagal syncope (VVS), or orthostatic hypotension (OH) were analysed...
September 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036197/morphometric-measurements-of-systemic-atherosclerosis-and-visceral-fat-evidence-from-an-autopsy-study
#16
Aline Nishizawa, Claudia K Suemoto, Daniela S Farias-Itao, Fernanda M Campos, Karen C S Silva, Marcio S Bittencourt, Lea T Grinberg, Renata E P Leite, Renata E L Ferretti-Rebustini, Jose M Farfel, Wilson Jacob-Filho, Carlos A Pasqualucci
BACKGROUND: Morphometric measurements of systemic atherosclerosis and direct quantification of visceral fat are only possible using materials from autopsy studies. However, the few autopsy studies that have investigated the association of visceral fat with atherosclerosis had small sample sizes and focused on coronary arteries of young or middle-aged White subjects. We aimed to investigate the association of pericardial fat (PF) and abdominal visceral fat (AVF) with atherosclerosis in the aorta, coronary, carotid, and cerebral arteries in a large autopsy study...
2017: PloS One
https://www.readbyqxmd.com/read/29035834/synergistic-effect-of-mild-hypothermia-and-the-notch-inhibitor-dapt-against-post-stroke-seizures
#17
Guo-Shuai Yang, Xiao-Yan Zhou, Xue-Fang An, Xuan-Jun Liu, Yan-Jun Zhang, Dan Yu
Seizure is a serious complication of stroke, indicating poor prognosis. Notch signaling is associated with neuronal activity. Inhibition of Notch signaling suppresses seizure activity induced by kainic acid. The present study investigated the effect of the Notch inhibitor, DAPT, alone or in combination with mild hypothermia, on post-stroke seizures. A global cerebral ischemia (GCI) model was performed in Sprague Dawley (SD) male rats. Seizure activity was evaluated by the frequency of seizure attacks, seizure severity scores, and seizure discharges...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29035833/vanillic-acid-attenuates-effects-of-transient-bilateral-common-carotid-occlusion-and-reperfusion-in-rats
#18
Seyed Esmaeil Khoshnam, Alireza Sarkaki, Layasadat Khorsandi, William Winlow, Mohammad Badavi, Hadi Fathi Moghaddam, Yaghoob Farbooda
Cerebral hypoperfusion induced by transient bilateral common carotid arteries occlusion (tBCCAO), is associated with deleterious alterations in several physiological parameters of the animals. This study aims to investigate the effects of vanillic acid (VA) on memory impairment, locomotion and exploratory deficits, as well as histological and hippocampal long-term potentiation (LTP) injuries induced by tBCCAO procedure followed by reperfusion (BCCAO/R) in rats. Adult male Wistar rats (250-300g) were divided randomly into four groups: Sham-Operated group "Sham"; Vehicle+BCCAO/R group "BCCAO/R"; Vehicle+ Vanillic acid group "VA"; VA (100mg/kg) +BCCAO/R group "VA +BCCAO/R"...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29035751/intercellular-transfer-of-pathogenic-%C3%AE-synuclein-by-extracellular-vesicles-is-induced-by-the-lipid-peroxidation-product-4-hydroxynonenal
#19
Shi Zhang, Erez Eitan, Tsung-Yu Wu, Mark P Mattson
Parkinson's disease (PD) is characterized by accumulations of toxic α-synuclein aggregates in vulnerable neuronal populations in the brainstem, midbrain, and cerebral cortex. Recent findings suggest that α-synuclein pathology can be propagated transneuronally, but the underlying molecular mechanisms are unknown. Advances in the genetics of rare early-onset familial PD indicate that increased production and/or reduced autophagic clearance of α-synuclein can cause PD. The cause of the most common late-onset PD is unclear, but may involve metabolic compromise and oxidative stress upstream of α-synuclein accumulation...
September 22, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29035676/the-molecular-mechanism-and-neuroprotective-effect-of-dihydrocapsaicin-induced-mild-hypothermia-after-cardiopulmonary-resuscitation-in-rats
#20
Xiaopeng Zhong, Xiujuan Wang, Fei Fei, ManCui Zhang, Po Ding, Shiwu Zhang
To investigate the molecular mechanism of dihydrocapsaicin (DHC)-induced mild hypothermia in rats, and to compare its protective effect on the central nervous system with that of a conventional method of inducing hypothermia, 24 healthy male Sprague Dawley rats were randomly divided into four groups based on the following conditions: control group, cardiopulmonary resuscitation (CPR) group, body surface cooling group, and DHC group. Tracheal clipping was used to mimic asphyxia arrest. Rats were assessed for their neurological deficit scores...
October 16, 2017: Therapeutic Hypothermia and Temperature Management
keyword
keyword
67636
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"