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https://www.readbyqxmd.com/read/29919988/amygdala-and-emotionality-in-parkinson-s-disease-an-integrative-review-of-the-neuropsychological-evidence
#1
(no author information available yet)
Parkinson\'s disease (PD) is often accompanied by significant changes in emotionality, such as apathy, anhedonia, anxiety and depression. The present review summarizes the empirical evidence, including amygdala changes and psychological changes in emotionality in people suffering with PD. Seventeen empirical full-text articles including research on both amygdala and emotionality in PD were reviewed.The changes in amygdala volumes as well as changes in binding potentials, functional connectivity, regional homogeneity and regional cerebral blood flow were found to have various impacts on emotionality in people with PD...
May 19, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29917239/sodium-nitroprusside-dilates-cerebral-vessels-and-enhances-internal-carotid-artery-flow-in-young-men
#2
Niels D Olesen, Mads Fischer, Niels H Secher
KEY POINTS: Sodium nitroprusside lowers blood pressure by vasodilation but is reported to reduce cerebral blood flow. In healthy young men sodium nitroprusside reduced blood pressure, total peripheral resistance, and arterial CO2 tension and yet cerebral blood flow was maintained with an increase in internal carotid artery blood flow and cerebrovascular conductance. Sodium nitroprusside induces both systemic and cerebral vasodilation affecting internal carotid artery more than vertebral artery flow...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917228/title-reduced-blood-volume-decreases-cerebral-blood-flow-in-preterm-piglets
#3
Yvonne A Eiby, Nicole Y Shrimpton, Ian M R Wright, Eugenie R Lumbers, Paul B Colditz, Greg J Duncombe, Barbara E Lingwood
Preterm infants often have impaired cardiovascular function that may contribute to poor neurodevelopmental outcomes. The study aimed to determine the effects of reduced blood volume on cardiovascular function, including cerebral blood flow in preterm and term piglets. In preterm (97/115d) and term piglets, up to 10% of the estimated blood volume was removed. Removal of blood was ceased if MAP dropped below 20 mmHg. Heart rate, cardiac contractility and relaxation, cardiac output, mean arterial pressure (MAP), and cerebral blood flow were measured at baseline and again after blood volume reduction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917211/cardiocerebral-protective-effects-of-dexmedetomidine-as-anesthetic-in-colorectal-cancer-surgery
#4
X-L Yi, J-T Wang, C-Q Chu, Y-X Li, J-H Yin, S-L Liu
OBJECTIVE: To explore the cardiocerebral protective effect of dexmedetomidine as an anesthetic in colorectal cancer surgery. PATIENTS AND METHODS: A total of 246 colorectal cancer patients were enrolled in this retrospective analysis. Those patients were admitted to the Affiliated Hospital of Qingdao University and underwent surgery from July 2014 to July 2016. The patients were divided into observation group and control group according to the anesthetic used in surgery...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917204/sestrin2-aggravates-oxidative-stress-of-neurons-by-decreasing-the-expression-of-nrf2
#5
L-L Zhang, Z-J Zhang
OBJECTIVE: Oxidative injury is an essential part of the pathological changes of cerebral ischemia-reperfusion. Sestrin2 (Sesn2), a conserved antioxidant protein, is activated under stress to protect cells against oxidative stress. This study mainly explored the function and mechanism of Sesn2 during cerebral ischemia-reperfusion injury in rats. MATERIALS AND METHODS: Oxygen-glucose deprivation/reoxygenation (OGD/R) model of primary neurons was established. MTS and LDH (lactate dehydrogenase) kit were used to detect cell viability and cell damage by colorimetric method...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917203/mirna-26a-promotes-angiogenesis-in-a-rat-model-of-cerebral-infarction-via-pi3k-akt-and-mapk-erk-pathway
#6
Z Liang, Y-J Chi, G-Q Lin, S-H Luo, Q-Y Jiang, Y-K Chen
OBJECTIVE: To investigate the specific role of microRNA-26 (miRNA-26a) in a rat model of cerebral ischemic stroke and the underlying mechanism. MATERIALS AND METHODS: A rat model of middle cerebral artery occlusion (MCAO) was established to induce permanent cerebral infarction. Neuro-behavior was observed and scored after model establishment. The expression of miRNA-26a in brain tissue and brain microvascular endothelial cells (BMECs) of rats after cerebral ischemic stroke was detected by quantitative polymerase chain reaction (qPCR)...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916544/yc%C3%A2-1-reduces-inflammatory-responses-by-inhibiting-nuclear-factor%C3%A2-%C3%AE%C2%BAb-translocation-in-mice-subjected-to-transient-focal-cerebral-ischemia
#7
Wei-Ting Lee, Shih-Huang Tai, Yu-Wen Lin, Tian-Shung Wu, E-Jian Lee
3‑(5‑hydroxymethyl‑2‑furyl)‑1‑benzyl‑indazole (YC‑1) is understood to protect against ischemic stroke, but the molecular basis for its neuroprotection remains to be fully characterized. The present study investigated the influence of YC‑1 on inflammatory responses following experimental stroke. Previous studies indicated that nuclear factor (NF)‑κB‑driven signals serve a pivotal role in mediating inflammatory responses following stroke. Ischemic stroke results in activation of NF‑κB to induce gene expression of factors including inducible nitric oxide synthase, interleukin (IL)‑1β, IL‑6 and matrix metalloproteinases (MMPs)...
June 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29916441/epidemiology-drug-resistance-and-pathophysiology-of-plasmodium-vivax-malaria
#8
REVIEW
Kiran K Dayananda, Rajeshwara N Achur, D Channe Gowda
Malaria, caused by the protozoan parasites of the genus Plasmodium, is a major health problem in many countries of the world. Five parasite species namely, Plasmodium falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi, cause malaria in humans. Of these, P. falciparum and P. vivax are the most prevalent and account for the majority of the global malaria cases. In most areas of Africa, P. vivax infection is essentially absent because of the inherited lack of Duffy antigen receptor for chemokines on the surface of red blood cells that is involved in the parasite invasion of erythrocytes...
January 2018: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29916142/lipotoxic-effects-of-palmitic-acid-on-astrocytes-are-associated-with-autophagy-impairment
#9
Ana Ortiz-Rodriguez, Estefania Acaz-Fonseca, Patricia Boya, Maria Angeles Arevalo, Luis M Garcia-Segura
Obesity is associated with an increase in the brain levels of saturated free fatty acids, such as palmitic acid (PA). Previous studies have shown that PA exerts proinflammatory actions and reduces cell viability in astrocyte cultures. In this study, we have assessed whether an alteration in autophagy is involved in the effects of PA on astrocytes. Primary astrocytes were obtained from the cerebral cortex of male and female CD1 mouse pups and were incubated for 4.5 or 24 h with 250-500 μM PA. PA increased the levels of LC3-II, an autophagosome marker, and reduced LC3-II flux in astrocytes, suggesting a blockade of autophagy...
June 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29916125/contribution-of-apelin-17-to-collateral-circulation-following-cerebral-ischemic-stroke
#10
Wan Jiang, Wei Hu, Li Ye, Yanghua Tian, Ren Zhao, Juan Du, Bing Shen, Kai Wang
Apelin, an essential mediator of homeostasis, is crucially involved in cardiovascular diseases, including ischemic stroke. However, the functional roles of apelin-17 in cerebral collateral circulation and ischemic stroke protection are unknown. Here, we investigated the association between plasma apelin-17 levels and collateral circulation in patients with ischemic stroke and examined the mechanism undergirding the effects of apelin-17 on cerebral artery contraction and ischemic stroke protection in an animal model...
June 18, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29916094/il-35-is-a-protective-immunomodulator-in-brain-ischemic-injury-in-mice
#11
Chen Xu, Hao Zhu, Rong Shen, Qian Feng, Hua Zhou, Zhong Zhao
IL-35 has been identified as a novel anti-inflammatory cytokine that belongs to the IL-12 cytokine family and has been verified to play a protective role in autoimmune diseases. In this study, we investigated the protective effects of IL-35 on cerebral ischemia/reperfusion (I/R) injury in a middle cerebral artery occlusion mouse model. We determined that the expression of IL-35 was initially decreased and subsequently increased in I/R injury. Moreover, IL-35 (i.c.v.) pre- and posttreatment significantly reduced the infarct volume and improved neurological deficits after 45 min of ischemia and 24 h of reperfusion...
July 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29916058/effects-of-systematic-partial-volume-errors-on-the-estimation-of-gray-matter-cerebral-blood-flow-with-arterial-spin-labeling-mri
#12
Jan Petr, Henri J M M Mutsaerts, Enrico De Vita, Rebecca M E Steketee, Marion Smits, Aart J Nederveen, Frank Hofheinz, Jörg van den Hoff, Iris Asllani
OBJECTIVE: Partial volume (PV) correction is an important step in arterial spin labeling (ASL) MRI that is used to separate perfusion from structural effects when computing the mean gray matter (GM) perfusion. There are three main methods for performing this correction: (1) GM-threshold, which includes only voxels with GM volume above a preset threshold; (2) GM-weighted, which uses voxel-wise GM contribution combined with thresholding; and (3) PVC, which applies a spatial linear regression algorithm to estimate the flow contribution of each tissue at a given voxel...
June 18, 2018: Magma
https://www.readbyqxmd.com/read/29915888/moyamoya-disease-in-pregnancy-a-systematic-review
#13
REVIEW
Georgios A Maragkos, Luis C Ascanio, Kohei Chida, Myles D Boone, Christopher S Ogilvy, Ajith J Thomas, Ekkehard M Kasper
BACKGROUND: Moyamoya disease (MMD) management during pregnancy poses a challenge to health care providers, and recommendations are outdated, vague, and controversial. We conducted a systematic review to investigate and present the available evidence. METHOD: We searched five online databases and bibliographies of relevant published original studies to identify case reports, case series, cohort studies, and reviews reporting on patients diagnosed with MMD before, during, or shortly after pregnancy...
June 19, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29915811/related-factors-of-early-mortality-in-young-adults-with-cerebral-hemorrhage
#14
Hong Xia Zhou, Nina Hao, Xiao Lin Xu
Background: The main causes of intracerebral hemorrhage differ between young adults and older adults. Data regarding potential targets for early intervention in young adult patients with intracerebral hemorrhage are lacking. Methods: We retrospectively analysed data for 196 young adult patients with intracerebral hemorrhage who were admitted to Tianjin Huanhu Hospital and died within 30 days of admission between June 2005 and June 2015. The Kaplan-Meier method was used to calculate survival rate, and the log-rank test was used to determine survival rate significance...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29915767/a-novel-surgical-correction-and-innovative-splint-for-swan-neck-deformity-in-hypermobility-syndrome
#15
Karthik Vishwanathan, Deepak Ganjiwale
Splinting is a great domain of occupational therapy profession. Making a splint for the patient would depend on the need or requirement of the problems and deformities. Swan neck deformity is an uncommon condition, and it can be seen in rheumatoid arthritis, cerebral palsy, and after trauma. Conservative treatment of the swan neck deformity is available by different static splints only. There are very few reports of surgical correction of swan-neck deformity in benign hypermobility syndrome. This case report describes the result of novel surgical intervention and an innovative hand splint in a 20-year-old female with a history of cardiovascular stroke with no residual neurological deficit...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915546/effect-of-acute-subacute-and-repeated-exposure-to-high-altitude-5050-m-on-psychomotor-vigilance
#16
Matiram Pun, Sara E Hartmann, Michael Furian, Adrienna M Dyck, Lara Muralt, Mona Lichtblau, Patrick R Bader, Jean M Rawling, Silvia Ulrich, Konrad E Bloch, Marc J Poulin
Aim: High altitude (HA) hypoxia may affect cognitive performance and sleep quality. Further, vigilance is reduced following sleep deprivation. We investigated the effect on vigilance, actigraphic sleep indices, and their relationships with acute mountain sickness (AMS) during very HA exposure, acclimatization, and re-exposure. Methods: A total of 21 healthy altitude-naive individuals (25 ± 4 years; 13 females) completed 2 cycles of altitude exposure separated by 7 days at low altitude (LA, 520 m). Participants slept at 2900 m and spent the day at HA, (5050 m)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29915395/treatment-of-endoscopy-associated-cerebral-gas-embolism
#17
Jeffr Cooper
No abstract text is available yet for this article.
June 19, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29915213/the-genotypic-and-phenotypic-spectrum-of-pars2-related-infantile-onset-encephalopathy
#18
Xiaomeng Yin, Beisha Tang, Xiao Mao, Jinxin Peng, Sheng Zeng, Yaqin Wang, Hong Jiang, Nan Li
Mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) are a family of enzymes that play critical roles in protein biosynthesis. Mutations in mt-aaRSs are associated with various diseases. As a member of the mt-aaRS family, PARS2 encoding prolyl-tRNA synthetase 2 was recently shown to be associated with Alpers syndrome and certain infantile-onset neurodegenerative disorders in four patients. Here, we present two patients in a pedigree with early developmental delay, epileptic spasms, delayed myelination combined with cerebellar white matter abnormalities, and progressive cortical atrophy...
June 18, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29915195/optimization-of-interneuron-function-by-direct-coupling-of-cell-migration-and-axonal-targeting
#19
Lynette Lim, Janelle M P Pakan, Martijn M Selten, André Marques-Smith, Alfredo Llorca, Sung Eun Bae, Nathalie L Rochefort, Oscar Marín
Neural circuit assembly relies on the precise synchronization of developmental processes, such as cell migration and axon targeting, but the cell-autonomous mechanisms coordinating these events remain largely unknown. Here we found that different classes of interneurons use distinct routes of migration to reach the embryonic cerebral cortex. Somatostatin-expressing interneurons that migrate through the marginal zone develop into Martinotti cells, one of the most distinctive classes of cortical interneurons...
June 18, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29915125/beyond-large-vessel-occlusion-strokes-distal-occlusion-thrombectomy
#20
Jonathan A Grossberg, Leticia C Rebello, Diogo C Haussen, Mehdi Bouslama, Meredith Bowen, Clara M Barreira, Samir R Belagaje, Michael R Frankel, Raul G Nogueira
BACKGROUND AND PURPOSE: Endovascular therapy is the standard of care for the treatment of proximal large vessel occlusion strokes. Its safety and efficacy in the treatment of distal intracranial occlusions has not been well studied. METHODS: The data that support the findings of this study are available from the corresponding author on reasonable request. Retrospective review of a prospectively collected endovascular database (2010-2015, n=949) for all patients with distal intracranial occlusions treated endovascularly...
June 18, 2018: Stroke; a Journal of Cerebral Circulation
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