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https://www.readbyqxmd.com/read/29346486/treatment-outcomes-and-adverse-events-following-in-office-angiolytic-laser-with-or-without-concurrent-polypectomy-for-vocal-fold-polyps
#1
Yu-Hsuan Lin, Chi-Te Wang, Feng-Chuan Lin, Li-Jen Liao, Wu-Chia Lo, Po-Wen Cheng
Importance: In-office angiolytic laser procedures have been used successfully as an alternative treatment for vocal fold polyps; little is known in detail about the treatment outcomes and adverse events. Objective: To examine the outcomes and incidence rates of adverse events associated with in-office angiolytic laser procedures with or without concurrent polypectomy as an alternative treatment for vocal fold polyps. Design, Setting, and Participants: Retrospective cohort study at a tertiary medical center...
January 18, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29346172/apremilast-use-in-a-case-of-cicatricial-ectropion-secondary-to-severe-lamellar-ichthyosis
#2
Jean-Paul J Abboud, Alexander Whittington, Masih Ahmed, Jesse T Himebaugh, Lee A Wiley, Ahmad Haffar, John Nguyen
Ichthyosis is a cutaneous disorder characterized by excessive amounts of dry thickened skin surface scales. Ocular manifestations of ichthyosis include cicatricial ectropion, which may cause exposure keratoconjunctivitis and rarely corneal perforation. Topical emollients, anti-inflammatory ointments, and systemic retinoids have been used to control the disease process, while surgical correction with donor graft has been reserved for severe cases involving corneal exposure. The authors report a case of a Caucasian male with lamellar ichthyosis with severe bilateral upper and lower eyelid cicatricial ectropion and corneal ulceration requiring surgical correction...
January 17, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29346155/diagnostic-and-therapeutic-ultrasound-on-venous-and-arterial-ulcers-a-focused-review
#3
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29346148/vertical-profunda-artery-perforator-flap-for-plantar-foot-wound-closure-a-new-application
#4
Allyson R Alfonso, James L Mayo, Vishal K Sharma, Robert J Allen, Ernest S Chiu
BACKGROUND: Plantar foot reconstruction requires special consideration of both form and function. There are several fasciocutaneous flap options, each with indications and reservations. CASE STUDY: This case presents a new application of the vertical profunda artery perforator flap for definitive closure of a neuropathic foot ulcer in a young woman with spina bifida. The postoperative course was uneventful, and the flap survived completely. The surgical and donor sites were without wound recurrence at 5-month follow-up...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29346147/hypoperfusion-and-wound-healing-another-dimension-of-wound-assessment
#5
Wendy Smollock, Paul Montenegro, Amy Czenis, Yuan He
OBJECTIVE: To examine the correlation between mean arterial pressure (MAP) and wound healing indices and describe an analytical process that can be used accurately and prospectively when evaluating all types of skin ulcerations. METHODS: A correlational study in a long-term-care facility.Participants (N = 230) were adults residing in a long-term-care facility with an average age of 77.8 years (range, 35-105). MAIN OUTCOME MEASURES: Assessment through both an index of wound healing and wound surface area...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29346146/use-of-oxidized-regenerated-cellulose-collagen-matrix-in-chronic-diabetic-foot-ulcers-a-systematic-review
#6
Gisele Chicone, Viviane Fernandes de Carvalho, André Oliveira Paggiaro
OBJECTIVE: Diabetic wounds that do not heal completely usually exhibit inflammatory markers, increased protease activity, and reduced levels of growth factors and cell count. A systematic review was performed to determine whether there is enough evidence to support the use of an oxidized regenerated cellulose/collagen matrix (ORC+C) to treat diabetic foot ulcers (DFUs). METHODS: Study authors analyzed randomized controlled trials (RCTs) on ORC+C dressings for the treatment of DFUs...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29346145/diagnostic-and-therapeutic-ultrasound-on-venous-and-arterial-ulcers-a-focused-review
#7
Steven J Kavros, Robert Coronado
GENERAL PURPOSE: To provide information about the use of ultrasound for diagnostic and therapeutic treatment of venous and arterial ulcers. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be able to: ABSTRACT: To review the diagnostic and therapeutic use of ultrasound on venous and arterial ulcers...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29345635/genetic-risk-dysbiosis-and-treatment-stratification-using-host-genome-and-gut-microbiome-in-inflammatory-bowel-disease
#8
Ahmed Moustafa, Weizhong Li, Ericka L Anderson, Emily H M Wong, Parambir S Dulai, William J Sandborn, William Biggs, Shibu Yooseph, Marcus B Jones, J Craig Venter, Karen E Nelson, John T Chang, Amalio Telenti, Brigid S Boland
OBJECTIVES: Inflammatory bowel diseases (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), are characterized by a complex pathophysiology that is thought to result from an aberrant immune response to a dysbiotic luminal microbiota in genetically susceptible individuals. New technologies support the joint assessment of host-microbiome interaction. METHODS: Using whole genome sequencing and shotgun metagenomics, we studied the clinical features, host genome, and stool microbial metagenome of 85 IBD patients, and compared the results to 146 control individuals...
January 18, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29345298/leishmania-amazonensis-isolated-from-human-visceral-leishmaniasis-histopathological-analysis-and-parasitological-burden-in-different-inbred-mice
#9
Celeste da Silva Freitas de Souza, Kátia da Silva Calabrese, Ana Lúcia Abreu-Silva, Luiz Otávio Pereira Carvalho, Flávia de Oliveira Cardoso, Maria Elizabeth Moraes Cavalheiros Dorval, Elisa Teruya Oshiro, Patrícia Flávia Quaresma, Célia Maria Ferreira Gontijo, Raquel da Silva Pacheco, Maria Isabel Doria Rossi, Sylvio Celso Gonçalves da Costa, Tânia Zaverucha do Valle
Leishmania amazonensis is a major etiological agent of human cutaneous leishmaniasis in the Americas; nevertheless there are some reports of this species causing visceral disease in dogs and men. In the present work we have studied a Leishmania strain isolated from a human case of visceral leishmaniasis. We have infected different mouse strains and analyzed the development of the disease, studying the parasite's ability to visceralize and whether this ability is influenced by host genetics. Female BALB/c, C57BL/6, C57BL/10, CBA, DBA/2, and C3H/He mice were subcutaneously infected with 104 L...
January 18, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29345146/quantitative-contrast-enhanced-ultrasound-for-monitoring-vedolizumab-therapy-in-inflammatory-bowel-disease-patients-a-pilot-study
#10
Ruediger S Goertz, Daniel Klett, Dane Wildner, Raja Atreya, Markus F Neurath, Deike Strobel
Background Microvascularization of the bowel wall can be visualized and quantified non-invasively by software-assisted analysis of derived time-intensity curves. Purpose To perform software-based quantification of bowel wall perfusion using quantitative contrast-enhanced ultrasound (CEUS) according to clinical response in patients with inflammatory bowel disease treated with vedolizumab. Material and Methods In a prospective study, in 18 out of 34 patients, high-frequency ultrasound of bowel wall thickness using color Doppler flow combined with CEUS was performed at baseline and after 14 weeks of treatment with vedolizumab...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29345029/high-prevalence-and-functional-effects-of-serum-antineuronal-antibodies-in-patients-with-gastrointestinal-disorders
#11
A Lütt, K Michel, D Krüger, M S Volz, M Nassir, E Schulz, L Poralla, P Tangermann, C Bojarski, M Höltje, B Teegen, W Stöcker, M Schemann, B Siegmund, H Prüss
BACKGROUND: Antineuronal antibodies can be associated with both gastrointestinal (GI) and brain disorders. For example, antibodies against the potassium channel subunit dipeptidyl-peptidase-like protein-6 (DPPX) bind to neurons in the central nervous system (CNS) and myenteric plexus and cause encephalitis, commonly preceded by severe unspecific GI symptoms. We therefore investigated the prevalence of antineuronal antibodies indicative of treatable autoimmune CNS etiologies in GI patients...
January 18, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29344607/bosentan-for-cutaneous-ulcers-in-anti-mda5-dermatomyositis
#12
Andrea Combalia, Priscila Giavedoni, Lorena Tamez, Josep M Grau-Junyent, Jose M Mascaró
No abstract text is available yet for this article.
January 17, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29344432/wt1-peptide-vaccine-in-montanide-in-contrast-to-poly-iclc-is-able-to-induce-wt1-specific-immune-response-with-tcr-clonal-enrichment-in-myeloid-leukemia
#13
Hongtao Liu, Yuanyuan Zha, Noura Choudhury, Gregory Malnassy, Noreen Fulton, Margaret Green, Jae-Hyun Park, Yusuke Nakamura, Richard A Larson, Andres M Salazar, Olatoyosi Odenike, Thomas F Gajewski, Wendy Stock
Background: The optimal strategy for vaccination to induce CD8+ T cell responses against WT1 is not known. Methods: A pilot randomized study in HLA-A02+ patients to receive vaccination with WT1 in Montanide or in poly ICLC, a TLR3 agonist, to explore the novel immune adjuvant was conducted. Seven patients were randomized. Four patients received WT1 in Montanide, and three with WT1 in poly ICLC. Five patients were in morphologic remission and two had residual morphologic disease at the study entry...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29344337/financial-burden-of-diabetic-foot-ulcers-to-world-a-progressive-topic-to-discuss-always
#14
REVIEW
Alok Raghav, Zeeshan Ahmad Khan, Rajendra Kumar Labala, Jamal Ahmad, Saba Noor, Brijesh Kumar Mishra
Diabetic foot complications are the most common occurring problems throughout the globe, resulting in devastating economic crises for the patients, families and society. Diabetic foot ulcers (DFUs) have a neuropathic origin with a progressive prevalence rate in developing countries compared with developed countries among diabetes mellitus patients. Diabetic patients that are of greatest risk of ulcers may easily be diagnosed with foot examination. Economic burden may be carefully examined. The budget costing must include both the clinical and social impact of the patients...
January 2018: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29344253/diagnostic-value-of-medical-thoracoscopy-in-malignant-pleural-effusion-induced-by-non-hodgkin-s-lymphoma
#15
Zhen Wang, Yan-Bing Wu, Li-Li Xu, Mu-Lan Jin, Xiao-Li Diao, Xiao-Juan Wang, Zhao-Hui Tong, Huan-Zhong Shi
Malignant pleural effusion (MPE) appears in up to 20% of patients with non-Hodgkin's lymphoma (NHL). The present study aimed to assess the efficacy of medical thoracoscopy (MT) in the diagnosis of patients with MPE induced by NHL. Between July 2005 and June 2014, 833 patients with pleural effusions of unknown etiology underwent MT in Beijing Chaoyang Hospital (Beijing, China), where diagnostic thoracocentesis or/and blind pleural biopsy had failed to yield an answer. Demographic, radiographic, thoracoscopic, histological and immunophenotyping data of 10 NHL patients with MPE were then retrospectively analyzed...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343899/flap-cover-in-a-patient-with-severe-haemophilia-type-a
#16
Narender Manickavachakan, Sunderraj Ellur, Vijay Thomas Mattyoo Joseph, Jonathan Victor, Cecil R Ross
Haemophilia A is a rare haematological disorder due to deficiency of Factor VIII, causing an abnormal coagulation response to injury. In severe haemophilia A, Factor VIII level is < 1%, often manifesting with spontaneous bleeding into joints. Judicious use of recombinant Factor VIII therapy to maintain adequate levels in the intraoperative, immediate and late post-operative periods, together with adjuvant pro-coagulants, can ensure a safe outcome following surgery. We describe the successful management of one such patient suffering from Marjolin's ulcer of the right gluteal region, who needed wide local excision followed by flap cover...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29343754/development-and-validation-of-a-brief-diabetic-foot-ulceration-risk-checklist-among-diabetic-patients-a-multicenter-longitudinal-study-in-china
#17
Qiuhong Zhou, Min Peng, Lihuan Zhou, Jiaojiao Bai, Ao Tong, Min Liu, In I Ng, Yuxia Cheng, Yunmin Cai, Yujin Yang, Yilian Chen, Suwen Gao, Zhong Li, Xiaoai Fu, Minxue Shen, Jianglin Zhang, Xiang Chen
The study aims to develop and assess and validate a brief diabetic foot ulceration risk checklist among diabetic patients through a longitudinal study. Patients who had diabetes mellitus and had no foot ulceration and severe systematic disorders were recruited from eleven tertiary hospitals in nine provinces or municipalities of China. Internal consistency reliability, construct validity, concurrent validity, item property, and measurement invariance of the tool were assessed. The predictive capability of the tool was validated by the follow-up data using the receiver operating characteristic curve...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343539/buruli-ulcer-review-of-a-neglected-skin-mycobacterial-disease
#18
Jeannette Guarner
Buruli ulcer is caused by Mycobacterium ulcerans This neglected disease occurs in scattered foci around the world with higher concentration of cases in West Africa. The mycobacteria produce mycolactones that cause tissue necrosis. The disease presents as a painless skin nodule that ulcerates as necrosis expands. Finding acid fast bacilli in smears or histopathology, culturing the mycobacteria, and performing M. ulcerans PCR in presumptive cases confirms the diagnosis. Medical treatment with oral rifampicin and intramuscular streptomycin or oral treatment with rifampicin plus clarithromycin for 8 weeks is supported by the World Health Organization...
January 17, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29342997/-x-linked-inhibitor-of-apoptosis-deficiency-manifested-as-crohn-s-disease-a-case-report-and-literature-review
#19
L J Xu, Y Y Luo, J D Yu, J G Lou, Y H Fang, J Chen
Objective: To analyze the clinical characteristics of X-linked inhibitor of apoptosis (XIAP) deficient patients with clinical manifestation of Crohn's disease. Methods: Clinical manifestations, laboratory investigations, genetic testing and therapeutic interventions of one case of XIAP deficiency who was admitted to Department of Gastroenterology in Children's Hospital, Zhejiang University School of Medicine in May 2016 were summarized. PubMed and Chinese database for articles published from January 2016 to June 2017 were searched using the key words of'Crohn's disease'and'XIAP', and the relevant literature was reviewed...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29342468/the-role-of-history-of-gastro-duodenal-ulcer-in-patients-with-upper-gastrointestinal-bleeding
#20
Yusaku Takatori, Motohiko Kato, Yukie Sunata, Yuichiro Hirai, Yoko Kubosawa, Keichiro Abe, Yoshiaki Takada, Tetsu Hirata, Shigeo Banno, Michiko Wada, Satoshi Kinoshita, Hideki Mori, Kaoru Takabayashi, Miho Kikuchi, Masahiro Kikuchi, Masayuki Suzuki, Toshio Uraoka
BACKGROUND: Some scoring systems have been introduced to predict the need for performing urgent endoscopy in patients with upper gastrointestinal bleeding (UGIB). However, in an emergency situation, this intervention is insufficient and cannot easily provide the required treatment. AIM: To identify new risk factors that can predict the need for endoscopic intervention (EI) in UGIB patients. METHODS: This is a retrospective cross-sectional study...
January 17, 2018: Digestive Diseases
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