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mazen hassanain

Balqis Alabdulkarim, Mazen Hassanain, Areej Bokhari, Abdulaziz AlSaif, Hana Alkarji
OBJECTIVES: In response to rising incidence and mortality we aimed to investigate the demographic characteristics of patients with operative breast cancer in our region. METHODS: We performed a retrospective study of 224 patients who underwent surgery for breast cancer at King Saud University Medical City, Riyadh, Kingdom of Saudi Arabia between 2005 and 2012. Results: We identified a young population overall with a mean age of 48.8±12.2 years (range: 26-93 years)...
May 2018: Saudi Medical Journal
Afnan Altamimi, Mazen Hassanain, Thamer Nouh, Khawlah Ateeq, Murad Aljiffry, Abrar Nawawi, Ghaith Al Saied, Mohammed Riaz, Huda Alanbar, Abdullah Altamimi, Saeed Alsareii, Mashael Al-Mousa, Abeer Al-Shammari, Saleh Alnuqaydan, Amal Ghzwany
Background/Aim: Emergency surgeries have increased in Saudi Arabia. This study examines these surgeries and associated complications. Patients and Methods: This was a prospective multicenter cohort study of patients undergoing emergency intraperitoneal surgery from the eight health sectors of Saudi Arabia. Patients' data were collected over 14 days. Results: In total, 283 patients were included (163 men [54.06%]). The majority of cases were open surgery (204 vs...
April 18, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Murad Aljiffry, Razan Habib, Eman Kotbi, Amro Ageel, Mazen Hassanain, Yaser Dahlan
PURPOSE: This study was carried out because intragastric balloon (IGB) is a widely used method to combat obesity, and acute pancreatitis complicating IGB is rare and yet to be understood. METHOD: This study was a retrospective analysis of all patients with a history of IGB insertion, who developed acute pancreatitis before balloon removal. RESULTS: A total of 4 cases were found, with a mean age of 27±2.9 years. The mean duration of IGB insertion was 2...
December 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Je-Gun Joung, Bo Young Oh, Hye Kyung Hong, Hisham Al-Khalidi, Faisal Al-Alem, Hae-Ock Lee, Joon Seol Bae, Jinho Kim, Hong-Ui Cha, Maram Alotaibi, Yong Beom Cho, Mazen Hassanain, Woong-Yang Park, Woo Yong Lee
Purpose: Tumors continuously evolve to maintain growth; secondary mutations facilitate this process, resulting in high tumor heterogeneity. In this study, we compared mutations in paired primary and metastatic colorectal cancer tumor samples to determine whether tumor heterogeneity can predict tumor metastasis. Experimental Design: Somatic variations in 46 pairs of matched primary-liver metastatic tumors and 42 primary tumors without metastasis were analyzed by whole-exome sequencing. Tumor clonality was estimated from single-nucleotide and copy-number variations...
December 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Eve Simoneau, Jarred Chicoine, Sarita Negi, Ayat Salman, Anthoula Lazaris, Mazen Hassanain, Nicole Beauchemin, Stephanie Petrillo, David Valenti, Ramila Amre, Peter Metrakos
Portal vein embolization (PVE) can be required to stimulate liver regeneration before hepatectomy for colorectal liver metastasis (CRCLM), however PVE may also trigger CRCLM progression in patients initially exhibiting chemotherapy response. Using RNA-seq, we aimed to determine the molecular networks involved in metastatic progression in this context. A prospective study including all CRCLM patients undergoing PVE prior to hepatectomy was conducted. Paired biopsies of metastatic lesions were obtained prior to and after PVE and total RNA was isolated and used to prepare Illumina rRNA-depleted TruSeq stranded cDNA libraries for HiSeq 100 bp paired-end sequencing...
June 2017: Clinical & Experimental Metastasis
Mazen Hassanain
Saudi Arabia's Ministry of Health (MOH) use corporate performance improvement methodologies to develop and implement performance improvement initiatives designed to continue building on the Ministry's vision of transforming hospital operations and instituting a culture of quality and performance focused on the "patient first" principle. We evaluated the feasibility of setting up a performance improvement unit (PIU) within the MOH to apply the principles of Lean Six Sigma and to change management methodologies...
January 1, 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
Faisal Al-Alem, Rafif Essam Mattar, Ola Abdelmonem Fadl, Abdulsalam Alsharabi, Faisal Al-Saif, Mazen Hassanain
BACKGROUND: Hepatic resection is a major surgical procedure. Data on outcomes of hepatectomy in Saudi Arabia are scarce. OBJECTIVE: To measure morbidity and mortality and assess predictors of outcome after hepatectomy. DESIGN: Descriptive study. SETTING: Tertiary care center in Saudi Arabia with well established hepatobiliary surgery unit. PATIENTS AND METHODS: All patients undergoing liver resection in our institute during 2006-2014...
November 2016: Annals of Saudi Medicine
Mazen Hassanain, Faisal Al-Alem, Eve Simoneau, Thamer A Traiki, Faisal Alsaif, Abdulsalam Alsharabi, Heba Al-Faris, Khalid Al-Saleh
BACKGROUND/AIM: To elucidate colorectal cancer (CRC) disease patterns, demographics, characteristics, stage at presentation, metastases, and survival rates of patients, particularly those with liver metastases, at our center as the first report from the Kingdom of Saudi Arabia. PATIENTS AND METHODS: We performed a retrospective, single-center database study based on the histological diagnosis of CRC in patients seen at the King Khalid University Hospital between 2007 and 2011...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Tamadar Aldoheyan, Mazen Hassanain, Amnah Al-Mulhim, Atheer Al-Sabhan, Shaden Al-Amro, Fahad Bamehriz, Hisham Al-Khalidi
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is associated with obesity. Bariatric surgery has been shown to be the most effective method for weight reduction. However, no conclusive data exists on the effects of weight reduction surgery on NAFLD. This study aimed to characterize liver histology, metabolic status, and liver function changes in patients who underwent bariatric surgery, before and after the weight-reduction procedure. This is a phase 1 report of a prospective cohort study of patients who underwent bariatric surgery...
March 2017: Surgical Endoscopy
Mazen Hassanain, Shirin Anil, Ayman Abdo
Increased financial and human resource constraints for research and development (R&D) imply rigorous research evaluation to guide the research policy for wise allocation of resources. In this study, we developed a conceptual framework called the "Institutional Research Evaluation Model" (IREM) to evaluate the quality of research and its determinants. The IREM was then applied to a medical institution to study its applicability in Saudi Arabia. The IREM consists of five levels: duration decision; choice of research quality indicators [impact factor (IF), article influence scores (AIS), citations per paper (CPP), and publication in indexed journal]; trend indicators (numbers of publications, study design, subject); data extraction; and statistical techniques to determine the factors affecting impact of research...
December 2016: Journal of Epidemiology and Global Health
Mazen Hassanain, Eve Simoneau, Suhail A Doi, Murad Aljiffry, Abdulla Aloraini, Ahmad Madkhali, Peter Metrakos
BACKGROUND: Driven by disease trends, such as obesity and metabolic syndrome, that are increasingly prevalent in the general population, we aimed to evaluate the comorbidities and attributes of the brain-dead organ donor population over time in a longitudinal study. METHODS: We compared overall health and baseline attributes of organ donors between 2000-2005 and 2006-2012 using our prospective transplant database. Descriptive and comparative analyses of the 2 historical cohorts were performed...
June 2016: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Eve Simoneau, Reema Alanazi, Jumanah Alshenaifi, Nouran Molla, Murad Aljiffry, Ahmad Medkhali, Louis-Martin Boucher, Jamil Asselah, Peter Metrakos, Mazen Hassanain
BACKGROUND AND OBJECTIVES: Treatment strategies for colorectal cancer liver metastasis (CRCLM) such as major hepatectomy and portal vein embolization (PVE) rely on liver regeneration. We aim to investigate the effect of neoadjuvant chemotherapy on liver regeneration occurring after PVE and after major hepatectomy. METHODS: CRCLM patients undergoing PVE or major resection were identified retrospectively from our database. Liver regeneration data (expressed as future liver remnant [FLR] and percentage of liver regeneration [%LR]), total liver volume (TLV) and clinical characteristics were collected...
March 2016: Journal of Surgical Oncology
Rafif E Mattar, Faisal Al-Alem, Eve Simoneau, Mazen Hassanain
Surgical resection of colorectal liver metastases (CRLM) has a well-documented improvement in survival. To benefit from this intervention, proper selection of patients who would be adequate surgical candidates becomes vital. A combination of imaging techniques may be utilized in the detection of the lesions. The criteria for resection are continuously evolving; currently, the requirements that need be met to undergo resection of CRLM are: the anticipation of attaining a negative margin (R0 resection), whilst maintaining an adequate functioning future liver remnant...
January 14, 2016: World Journal of Gastroenterology: WJG
Eman Al-Sharif, Eve Simoneau, Mazen Hassanain
Colorectal liver metastasis (CRLM) is the major cause of death in patients diagnosed with colorectal cancer. The gold standard treatment of CRLM is surgical resection. Yet, in the past, more than half of these patients were deemed unresectable due to the inadequate future liver remnant (FLR). The introduction of efficient portal vein embolization (PVE) preoperatively allowed more resections of metastasis in CRLM patients by stimulating adequate liver hypertrophy. However, several experimental and clinical studies reported tumor progression after PVE which critically influences the subsequent management of these patients...
October 10, 2015: World Journal of Clinical Oncology
Mazen Hassanain, Eve Simoneau, Ahmad Madkhali, Nouf Al-Saati, Murad Aljiffry, Jean Tchervenkov, Jeffrey Barkun, Peter Metrakos
BACKGROUND: Currently, there is no universally accepted method to evaluate liver function post-orthotopic liver transplant (OLTx) and there are no early surrogate function markers to assess the impact of perioperative interventions in trial settings. MATERIAL AND METHODS: In total, 495 patients were included in the study. On multivariate analysis, PTLF score, defined as normal (score <4) or dysfunctional (score ≥ 4), was the only significant variable for determining significant complications (P=0...
2015: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Rasha AlShaalan, Murad Aljiffry, Said Al-Busafi, Peter Metrakos, Mazen Hassanain
Hepatic steatosis is the buildup of lipids within hepatocytes. It is the simplest stage in nonalcoholic fatty liver disease (NAFLD). It occurs in approximately 30% of the general population and as much as 90% of the obese population in the United States. It may progress to nonalcoholic steatohepatitis, which is a state of hepatocellular inflammation and damage in response to the accumulated fat. Liver biopsy remains the gold standard tool to diagnose and stage NAFLD. However, it comes with the risk of complications ranging from simple pain to life-threatening bleeding...
March 2015: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Ahmad A Madkhali, Zahir T Fadel, Murad M Aljiffry, Mazen M Hassanain
Hepatocellular carcinoma (HCC) is an epithelial tumor derived from hepatocytes; it accounts for 80% of all primary liver cancers and ranks globally as the fourth leading cause of cancer-related deaths. HCC treatment is a multidisciplinary and a multimodal task, with surgery in the form of liver resection and liver transplantation (LT) representing the only potentially curative modality. However, there are variable opinions and discussions about applying these surgical options and using other supporting treatments...
January 2015: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Thamer A Bin Traiki, Ahmad A Madkhali, Mazen M Hassanain
Hepatic artery pseudoaneurysm is a rare complication of laparoscopic cholecystectomy. A high index of suspicion and early identification and therapy are important points needed to prevent rupture. We report a case of complex biliary and vascular injuries 4 weeks after a laparoscopic cholecystectomy. The patient had recurrent bleeding from a hepatic artery pseudoaneurysm that has been treated successfully with angiographic stenting and embolization.
2015: Journal of Surgical Case Reports
Nasser Abualhassan, Murad Aljiffry, Lukman Thalib, Razek Coussa, Peter Metrakos, Mazen Hassanain
Venous thromboembolic events (VTEs) are a major cause of post-operative morbidity and mortality. Our objective is to establish the prevalence of VTEs in kidney transplant recipients and assess its impact on graft survival. Data regarding renal transplant patients with VTEs from 1985 to 2010 were identified and analyzed. After excluding recipients of combined grafts and late VTE development, 1596 recipients were included in this analysis. The prevalence of post-operative VTEs and graft survival were determined...
January 2015: Saudi Journal of Kidney Diseases and Transplantation
Murad Aljiffry, Mawaddah Alrajraji, Salman Al-Sabah, Mazen Hassanain
Laparoscopic approaches have been increasingly used in selected patients with either colorectal or liver cancer. However, simultaneous resection of colorectal carcinoma with synchronous liver metastases is still a subject of debate. The present case describes combined laparoscopic rectal and liver resections for a patient with primary rectal cancer and a synchronous liver metastasis utilizing a Pfannenstiel incision for specimen extraction. The operative time was 370 min and estimated blood loss was 400 mL...
September 2014: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
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