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mazen hassanain

Mazen Hassanain, Faisal Al-Alem, Eve Simoneau, Thamer A Traiki, Faisal Alsaif, Abdulsalam Alsharabi, Heba Al-Faris, Khalid Al-Saleh
BACKGROUND/AIM: To elucidate colorectal cancer (CRC) disease patterns, demographics, characteristics, stage at presentation, metastases, and survival rates of patients, particularly those with liver metastases, at our center as the first report from the Kingdom of Saudi Arabia. PATIENTS AND METHODS: We performed a retrospective, single-center database study based on the histological diagnosis of CRC in patients seen at the King Khalid University Hospital between 2007 and 2011...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Tamadar Aldoheyan, Mazen Hassanain, Amnah Al-Mulhim, Atheer Al-Sabhan, Shaden Al-Amro, Fahad Bamehriz, Hisham Al-Khalidi
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is associated with obesity. Bariatric surgery has been shown to be the most effective method for weight reduction. However, no conclusive data exists on the effects of weight reduction surgery on NAFLD. This study aimed to characterize liver histology, metabolic status, and liver function changes in patients who underwent bariatric surgery, before and after the weight-reduction procedure. This is a phase 1 report of a prospective cohort study of patients who underwent bariatric surgery...
July 12, 2016: Surgical Endoscopy
Mazen Hassanain, Shirin Anil, Ayman Abdo
Increased financial and human resource constraints for research and development (R&D) imply rigorous research evaluation to guide the research policy for wise allocation of resources. In this study, we developed a conceptual framework called the "Institutional Research Evaluation Model" (IREM) to evaluate the quality of research and its determinants. The IREM was then applied to a medical institution to study its applicability in Saudi Arabia. The IREM consists of five levels: duration decision; choice of research quality indicators [impact factor (IF), article influence scores (AIS), citations per paper (CPP), and publication in indexed journal]; trend indicators (numbers of publications, study design, subject); data extraction; and statistical techniques to determine the factors affecting impact of research...
April 16, 2016: Journal of Epidemiology and Global Health
Mazen Hassanain, Eve Simoneau, Suhail A Doi, Murad Aljiffry, Abdulla Aloraini, Ahmad Madkhali, Peter Metrakos
BACKGROUND: Driven by disease trends, such as obesity and metabolic syndrome, that are increasingly prevalent in the general population, we aimed to evaluate the comorbidities and attributes of the brain-dead organ donor population over time in a longitudinal study. METHODS: We compared overall health and baseline attributes of organ donors between 2000-2005 and 2006-2012 using our prospective transplant database. Descriptive and comparative analyses of the 2 historical cohorts were performed...
June 2016: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Eve Simoneau, Reema Alanazi, Jumanah Alshenaifi, Nouran Molla, Murad Aljiffry, Ahmad Medkhali, Louis-Martin Boucher, Jamil Asselah, Peter Metrakos, Mazen Hassanain
BACKGROUND AND OBJECTIVES: Treatment strategies for colorectal cancer liver metastasis (CRCLM) such as major hepatectomy and portal vein embolization (PVE) rely on liver regeneration. We aim to investigate the effect of neoadjuvant chemotherapy on liver regeneration occurring after PVE and after major hepatectomy. METHODS: CRCLM patients undergoing PVE or major resection were identified retrospectively from our database. Liver regeneration data (expressed as future liver remnant [FLR] and percentage of liver regeneration [%LR]), total liver volume (TLV) and clinical characteristics were collected...
March 2016: Journal of Surgical Oncology
Rafif E Mattar, Faisal Al-Alem, Eve Simoneau, Mazen Hassanain
Surgical resection of colorectal liver metastases (CRLM) has a well-documented improvement in survival. To benefit from this intervention, proper selection of patients who would be adequate surgical candidates becomes vital. A combination of imaging techniques may be utilized in the detection of the lesions. The criteria for resection are continuously evolving; currently, the requirements that need be met to undergo resection of CRLM are: the anticipation of attaining a negative margin (R0 resection), whilst maintaining an adequate functioning future liver remnant...
January 14, 2016: World Journal of Gastroenterology: WJG
Eman Al-Sharif, Eve Simoneau, Mazen Hassanain
Colorectal liver metastasis (CRLM) is the major cause of death in patients diagnosed with colorectal cancer. The gold standard treatment of CRLM is surgical resection. Yet, in the past, more than half of these patients were deemed unresectable due to the inadequate future liver remnant (FLR). The introduction of efficient portal vein embolization (PVE) preoperatively allowed more resections of metastasis in CRLM patients by stimulating adequate liver hypertrophy. However, several experimental and clinical studies reported tumor progression after PVE which critically influences the subsequent management of these patients...
October 10, 2015: World Journal of Clinical Oncology
Mazen Hassanain, Eve Simoneau, Ahmad Madkhali, Nouf Al-Saati, Murad Aljiffry, Jean Tchervenkov, Jeffrey Barkun, Peter Metrakos
BACKGROUND: Currently, there is no universally accepted method to evaluate liver function post-orthotopic liver transplant (OLTx) and there are no early surrogate function markers to assess the impact of perioperative interventions in trial settings. MATERIAL AND METHODS: In total, 495 patients were included in the study. On multivariate analysis, PTLF score, defined as normal (score <4) or dysfunctional (score ≥ 4), was the only significant variable for determining significant complications (P=0...
2015: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Rasha AlShaalan, Murad Aljiffry, Said Al-Busafi, Peter Metrakos, Mazen Hassanain
Hepatic steatosis is the buildup of lipids within hepatocytes. It is the simplest stage in nonalcoholic fatty liver disease (NAFLD). It occurs in approximately 30% of the general population and as much as 90% of the obese population in the United States. It may progress to nonalcoholic steatohepatitis, which is a state of hepatocellular inflammation and damage in response to the accumulated fat. Liver biopsy remains the gold standard tool to diagnose and stage NAFLD. However, it comes with the risk of complications ranging from simple pain to life-threatening bleeding...
March 2015: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Ahmad A Madkhali, Zahir T Fadel, Murad M Aljiffry, Mazen M Hassanain
Hepatocellular carcinoma (HCC) is an epithelial tumor derived from hepatocytes; it accounts for 80% of all primary liver cancers and ranks globally as the fourth leading cause of cancer-related deaths. HCC treatment is a multidisciplinary and a multimodal task, with surgery in the form of liver resection and liver transplantation (LT) representing the only potentially curative modality. However, there are variable opinions and discussions about applying these surgical options and using other supporting treatments...
January 2015: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Thamer A Bin Traiki, Ahmad A Madkhali, Mazen M Hassanain
Hepatic artery pseudoaneurysm is a rare complication of laparoscopic cholecystectomy. A high index of suspicion and early identification and therapy are important points needed to prevent rupture. We report a case of complex biliary and vascular injuries 4 weeks after a laparoscopic cholecystectomy. The patient had recurrent bleeding from a hepatic artery pseudoaneurysm that has been treated successfully with angiographic stenting and embolization.
2015: Journal of Surgical Case Reports
Nasser Abualhassan, Murad Aljiffry, Lukman Thalib, Razek Coussa, Peter Metrakos, Mazen Hassanain
Venous thromboembolic events (VTEs) are a major cause of post-operative morbidity and mortality. Our objective is to establish the prevalence of VTEs in kidney transplant recipients and assess its impact on graft survival. Data regarding renal transplant patients with VTEs from 1985 to 2010 were identified and analyzed. After excluding recipients of combined grafts and late VTE development, 1596 recipients were included in this analysis. The prevalence of post-operative VTEs and graft survival were determined...
January 2015: Saudi Journal of Kidney Diseases and Transplantation
Murad Aljiffry, Mawaddah Alrajraji, Salman Al-Sabah, Mazen Hassanain
Laparoscopic approaches have been increasingly used in selected patients with either colorectal or liver cancer. However, simultaneous resection of colorectal carcinoma with synchronous liver metastases is still a subject of debate. The present case describes combined laparoscopic rectal and liver resections for a patient with primary rectal cancer and a synchronous liver metastasis utilizing a Pfannenstiel incision for specimen extraction. The operative time was 370 min and estimated blood loss was 400 mL...
September 2014: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Aisha Abdulrahman, Alaa Shabkah, Mazen Hassanain, Murad Aljiffry
INTRODUCTION: Splenic artery aneurysm is a rare condition, however, potentially fatal. The importance of splenic artery aneurysm lies in the risk for rupture and life threatening hemorrhage. PRESENTATION OF CASE: This is a case of a ruptured splenic artery aneurysm in a 58-year-old lady. She presented with hypovolemic shock and intra-peritoneal bleeding. Diagnosis was confirmed by CT angiography and she was managed by operative ligation of the aneurysm with splenectomy and distal pancreatectomy...
2014: International Journal of Surgery Case Reports
Murad M Aljiffry, Amna N Almulhim, Mohammad H Jamal, Mazen M Hassanain
Haemorrhagic cholecystitis is a known rare life-threatening complication of acute cholecystitis. In this case report, we describe clinical presentation and radiological findings of acute cholecystitis presenting with massive intra-abdominal haemorrhage. We present a case of a 57-year-old male presenting to the emergency department with clinical symptoms of acute cholecystitis. Initially, the patient was haemodynamically stable. Gallbladder could not be visualized by ultrasound. Computed tomography with IV contrast showed a large haematoma in the gallbladder fossa, with active extravasation of IV contrast...
2014: Journal of Surgical Case Reports
Mazen Hassanain
Donor transmitted malignancy is a real disastrous risk when dealing with expanded criteria donors. As donor age is increasing, guidelines for cancer screening of the elderly brain dead organ donors must be evidence-based but systematic review of such is sparse. Based on a review of published literature and our 20 years' experience, we propose a new series of guidelines concerning screening for the four most common malignancies: breast colon, lung and prostate cancer. Prospective testing of the efficacy of such protocol will then follow...
2014: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Majid A Almadi, Othman Alharbi, Nahla Azzam, Mohannad Altayeb, Moammed Javed, Faisal Alsaif, Mazen Hassanain, Abdulsalam Alsharabi, Khalid Al-Saleh, Abdulrahman M Aljebreen
BACKGROUND/AIMS: Identifying patient-related factors as well as symptoms and signs that can predict pancreatic cancer at a resectable stage, which could be used in an attempt to identify patients at an early stage of pancreatic cancer that would be appropriate for surgical resection and those at an unresectable stage be sparred unnecessary surgery. MATERIALS AND METHODS: A retrospective chart review was conducted at a major tertiary care, university hospital in Riyadh, Saudi Arabia...
November 2013: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Nassima Smail, Jean Tchervenkov, Steven Paraskevas, Dana Baran, Istvan Mucsi, Mazen Hassanain, Prosanto Chaudhury, Marcelo Cantarovich
BACKGROUND: The use of kidneys from expanded-criteria donors (ECD) is regarded with caution. METHODS: We compared 279 kidney transplant recipients (KTxR) from standard-criteria donors (SCD) and 237 from ECD, transplanted between January 1990 and December 2006. We evaluated the impact of immediate graft function (IGF), slow graft function (SGF), and delayed graft function (DGF) and the drop in estimated glomerular filtration rate (ΔeGFR) ≤ 30% or > 30% during the first year after transplantation on long-term patient and death-censored graft survival (DCGS)...
July 27, 2013: Transplantation
Sinziana Dumitra, Mohammad H Jamal, Jad Aboukhalil, Suhail A Doi, Prosanto Chaudhury, Mazen Hassanain, Peter P Metrakos, Jeffrey S Barkun
INTRODUCTION: Few tools predict survival from pancreatic cancer (PAC). The McGill Brisbane Symptom Score (MBSS) based on symptoms at presentation (weight loss, pain, jaundice and smoking) was recently validated. The present study compares the ability of four strategies to predict 9-month survival: MBSS, carbohydrate antigen 19-9 (CA 19-9) alone, CA19-9-to-bilirubin ratio and a combination of MBSS and the CA19-9-to-bilirubin ratio. METHODOLOGY: A retrospective review of 133 patients diagnosed with PAC between 2005 and 2011 was performed...
December 2013: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Sinziana Dumitra, Salleh I Alabbad, Jeffrey S Barkun, Teodora C Dumitra, Dimitrios Coutsinos, Peter P Metrakos, Mazen Hassanain, Steven Paraskevas, Prosanto Chaudhury, Jean I Tchervenkov
BACKGROUND: Hepatitis C infection (HCV) and hepatocellular carcinoma (HCC), the two main causes of liver transplantation (LT), have reduced survival post-LT. The impact of HCV, HCC and their coexistence on post-LT survival were assessed. METHODOLOGY: All 601 LT patients from 1992 to 2011 were reviewed. Those deceased within 30 days (n = 69) and re-transplants (n = 49) were excluded. Recipients were divided into four groups: (a) HCC-/HCV-(n = 252) (b) HCC+/HCV- (n = 58), (c) HCC-/HCV+ (n = 106) and (d) HCC+/HCV+ (n = 67)...
September 2013: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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