keyword
MENU ▼
Read by QxMD icon Read
search

Lyl1

keyword
https://www.readbyqxmd.com/read/27851970/the-hematopoietic-transcription-factors-runx1-and-erg-prevent-aml1-eto-oncogene-overexpression-and-onset-of-the-apoptosis-program-in-t-8-21-amls
#1
Amit Mandoli, Abhishek A Singh, Koen H M Prange, Esther Tijchon, Marjolein Oerlemans, Rene Dirks, Menno Ter Huurne, Albertus T J Wierenga, Eva M Janssen-Megens, Kim Berentsen, Nilofar Sharifi, Bowon Kim, Filomena Matarese, Luan N Nguyen, Nina C Hubner, Nagesha A Rao, Emile van den Akker, Lucia Altucci, Edo Vellenga, Hendrik G Stunnenberg, Joost H A Martens
The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated its effects on the transcriptome and epigenome in t(8,21) patient cells. AML1-ETO binding was found at promoter regions of active genes with high levels of histone acetylation but also at distal elements characterized by low acetylation levels and binding of the hematopoietic transcription factors LYL1 and LMO2. In contrast, ERG, FLI1, TAL1, and RUNX1 bind at all AML1-ETO-occupied regulatory regions, including those of the AML1-ETO gene itself, suggesting their involvement in regulating AML1-ETO expression levels...
November 15, 2016: Cell Reports
https://www.readbyqxmd.com/read/27191957/trib2-suppresses-tumor-initiation-in-notch-driven-t-all
#2
Sarah J Stein, Ethan A Mack, Kelly S Rome, Kostandin V Pajcini, Takuya Ohtani, Lanwei Xu, Yunlei Li, Jules P P Meijerink, Robert B Faryabi, Warren S Pear
Trib2 is highly expressed in human T cell acute lymphoblastic leukemia (T-ALL) and is a direct transcriptional target of the oncogenic drivers Notch and TAL1. In human TAL1-driven T-ALL cell lines, Trib2 is proposed to function as an important survival factor, but there is limited information about the role of Trib2 in primary T-ALL. In this study, we investigated the role of Trib2 in the initiation and maintenance of Notch-dependent T-ALL. Trib2 had no effect on the growth and survival of murine T-ALL cell lines in vitro when expression was blocked by shRNAs...
2016: PloS One
https://www.readbyqxmd.com/read/27137657/scl-tal1-in-hematopoiesis-and-cellular-reprogramming
#3
T Hoang, J A Lambert, R Martin
SCL, a transcription factor of the basic helix-loop-helix family, is a master regulator of hematopoiesis. Scl specifies lateral plate mesoderm to a hematopoietic fate and establishes boundaries by inhibiting the cardiac lineage. A combinatorial interaction between Scl and Vegfa/Flk1 sets in motion the first wave of primitive hematopoiesis. Subsequently, definitive hematopoietic stem cells (HSCs) emerge from the embryo proper via an endothelial-to-hematopoietic transition controlled by Runx1, acting with Scl and Gata2...
2016: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/27050553/generation-of-large-numbers-of-antigen-expressing-human-dendritic-cells-using-cd14-ml-technology
#4
Yuya Imamura, Miwa Haruta, Yusuke Tomita, Keiko Matsumura, Tokunori Ikeda, Akira Yuno, Masatoshi Hirayama, Hideki Nakayama, Hiroshi Mizuta, Yasuharu Nishimura, Satoru Senju
We previously reported a method to expand human monocytes through lentivirus-mediated introduction of cMYC and BMI1, and we named the monocyte-derived proliferating cells, CD14-ML. CD14-ML differentiated into functional DC (CD14-ML-DC) upon addition of IL-4, resulting in the generation of a large number of DC. One drawback of this method was the extensive donor-dependent variation in proliferation efficiency. In the current study, we found that introduction of BCL2 or LYL1 along with cMYC and BMI1 was beneficial...
2016: PloS One
https://www.readbyqxmd.com/read/26148230/the-oncofusion-protein-fus-erg-targets-key-hematopoietic-regulators-and-modulates-the-all-trans-retinoic-acid-signaling-pathway-in-t-16-21-acute-myeloid-leukemia
#5
A M Sotoca, K H M Prange, B Reijnders, A Mandoli, L N Nguyen, H G Stunnenberg, J H A Martens
The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion with FUS/TLS resulting in the expression of a FUS-ERG oncofusion protein. How this oncofusion protein deregulates the normal ERG transcription program is unclear. Here, we show that FUS-ERG acts in the context of a heptad of proteins (ERG, FLI1, GATA2, LYL1, LMO2, RUNX1 and TAL1) central to proper expression of genes involved in maintaining a stem cell hematopoietic phenotype...
April 14, 2016: Oncogene
https://www.readbyqxmd.com/read/25706938/a-population-based-single-nucleotide-polymorphism-array-analysis-of-genomic-aberrations-in-younger-adult-acute-lymphoblastic-leukemia-patients
#6
Vaidas Dirse, Agne Bertasiute, Egle Gineikiene, Tadas Zvirblis, Ruta Dambrauskiene, Rolandas Gerbutavicius, Elona Juozaityte, Ligita Malciute, Kajsa Paulsson, Laimonas Griskevicius
Adult acute lymphoblastic leukemia (ALL) is characterized by a high frequency of abnormal karyotypes some of which are related to outcome. Single nucleotide polymorphism (SNP) array analysis provides a highly sensitive platform to detect large and small genomic aberrations. SNP array profiling data in adult ALL are limited and further systematic studies of this patient group are needed. We performed a population-based SNP array analysis of genomic aberrations and their influence on survival in 66 Lithuanian 18-65 year old ALL patients diagnosed between 2007 and 2013...
May 2015: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/25605239/expression-of-the-potential-therapeutic-target-cxxc5-in-primary-acute-myeloid-leukemia-cells-high-expression-is-associated-with-adverse-prognosis-as-well-as-altered-intracellular-signaling-and-transcriptional-regulation
#7
Øystein Bruserud, Håkon Reikvam, Hanne Fredly, Jørn Skavland, Karen-Marie Hagen, Tuyen Thy van Hoang, Annette K Brenner, Amir Kadi, Audrey Astori, Bjørn Tore Gjertsen, Frederic Pendino
The CXXC5 gene encodes a transcriptional activator with a zinc-finger domain, and high expression in human acute myeloid leukemia (AML) cells is associated with adverse prognosis. We now characterized the biological context of CXXC5 expression in primary human AML cells. The global gene expression profile of AML cells derived from 48 consecutive patients was analyzed; cells with high and low CXXC5 expression then showed major differences with regard to extracellular communication and intracellular signaling...
February 20, 2015: Oncotarget
https://www.readbyqxmd.com/read/25522233/scl-lmo1-and-notch1-reprogram-thymocytes-into-self-renewing-cells
#8
Bastien Gerby, Cedric S Tremblay, Mathieu Tremblay, Shanti Rojas-Sutterlin, Sabine Herblot, Josée Hébert, Guy Sauvageau, Sébastien Lemieux, Eric Lécuyer, Diogo F T Veiga, Trang Hoang
The molecular determinants that render specific populations of normal cells susceptible to oncogenic reprogramming into self-renewing cancer stem cells are poorly understood. Here, we exploit T-cell acute lymphoblastic leukemia (T-ALL) as a model to define the critical initiating events in this disease. First, thymocytes that are reprogrammed by the SCL and LMO1 oncogenic transcription factors into self-renewing pre-leukemic stem cells (pre-LSCs) remain non-malignant, as evidenced by their capacities to generate functional T cells...
December 2014: PLoS Genetics
https://www.readbyqxmd.com/read/25499232/enforced-expression-of-e47-has-differential-effects-on-lmo2-induced-t-cell-leukemias
#9
Charnise Goodings, Rati Tripathi, Susan M Cleveland, Natalina Elliott, Yan Guo, Yu Shyr, Utpal P Davé
LIM domain only-2 (LMO2) overexpression in T cells induces leukemia but the molecular mechanism remains to be elucidated. In hematopoietic stem and progenitor cells, Lmo2 is part of a protein complex comprised of class II basic helix loop helix proteins, Tal1and Lyl1. The latter transcription factors heterodimerize with E2A proteins like E47 and Heb to bind E boxes. LMO2 and TAL1 or LYL1 cooperate to induce T-ALL in mouse models, and are concordantly expressed in human T-ALL. Furthermore, LMO2 cooperates with the loss of E2A suggesting that LMO2 functions by creating a deficiency of E2A...
January 2015: Leukemia Research
https://www.readbyqxmd.com/read/25404153/friend-or-foe-can-activating-mutations-in-notch1-contribute-to-a-favorable-treatment-outcome-in-patients-with-t-all
#10
REVIEW
Aviya Goldshtein, Michael Berger
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes. Despite significant improvement in the treatment of T-ALL, approximately 20% of children and most adults succumb to resistant or relapsed disease. Transformation events occur during crucial steps of thymocyte development and have been related to the expression of certain oncogenes such as TAL2, TLX1, LYL1, LMO1, and NOTCH1. Mutations that lead to constitutive activation of NOTCH1 are most commonly found in human patients with T-ALL...
2014: Critical Reviews in Oncogenesis
https://www.readbyqxmd.com/read/25319996/divergent-functions-of-hematopoietic-transcription-factors-in-lineage-priming-and-differentiation-during-erythro-megakaryopoiesis
#11
Maxim Pimkin, Andrew V Kossenkov, Tejaswini Mishra, Christapher S Morrissey, Weisheng Wu, Cheryl A Keller, Gerd A Blobel, Dongwon Lee, Michael A Beer, Ross C Hardison, Mitchell J Weiss
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, TAL1, and FLI1) and three diagnostic histone modification marks with the gene expression changes that occur during development of primary cultured megakaryocytes (MEG) and primary erythroblasts (ERY) from murine fetal liver hematopoietic stem/progenitor cells...
December 2014: Genome Research
https://www.readbyqxmd.com/read/25035669/prognostic-significance-of-the-lymphoblastic-leukemia-derived-sequence-1-lyl1-geneexpression-in-egyptian-patients-with-acutemyeloid-leukemia
#12
Nadia El-Menshawy, Doaa Shahin, Hayam Fathi Ghazi
OBJECTIVE: Aberrant activation of transcription factor genes is the most frequent target of genetic alteration in lymphoid malignancies. The lymphoblastic leukemia-derived sequence 1 (LYL1) gene, which encodes a basic helix-loop helix, was first identified with human T-cell acute leukemia. Recent studies suggest its involvement in myeloid malignancies. We aimed to study the expression percent of oncogene LYL1 in primary and secondary high-risk myeloid leukemia and the impact on prognostic significance in those patients...
June 2014: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/24647404/identification-of-genes-differentially-expressed-in-myogenin-knock-down-bovine-muscle-satellite-cells-during-differentiation-through-rna-sequencing-analysis
#13
Eun Ju Lee, Adeel Malik, Smritee Pokharel, Sarafraz Ahmad, Bilal Ahmad Mir, Kyung Hyun Cho, Jihoe Kim, Joon Chan Kong, Dong-Mok Lee, Ki Yong Chung, Sang Hoon Kim, Inho Choi
BACKGROUND: The expression of myogenic regulatory factors (MRFs) consisting of MyoD, Myf5, myogenin (MyoG) and MRF4 characterizes various phases of skeletal muscle development including myoblast proliferation, cell-cycle exit, cell fusion and the maturation of myotubes to form myofibers. Although it is well known that the function of MyoG cannot be compensated for other MRFs, the molecular mechanism by which MyoG controls muscle cell differentiation is still unclear. Therefore, in this study, RNA-Seq technology was applied to profile changes in gene expression in response to MyoG knock-down (MyoGkd) in primary bovine muscle satellite cells (MSCs)...
2014: PloS One
https://www.readbyqxmd.com/read/24596673/extreme-hyperleukocytosis-in-a-pediatric-t-all-patient-with-a-rare-translocation-t-7-19-q35-p13-and-submicroscopic-deletions-at-4q25-7q33-and-10q23
#14
Christopher Veigaard, Anni Aggerholm, Henrik Hasle, Eigil Kjeldsen
Although childhood T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk disease the outcome can vary considerably. The varying outcomes suggest that unrecognized factors may contribute to disease progression. We report on a 2-year-old T-ALL patient presenting with a very short history of constipation and extreme hyperleukocytosis (WBC 882×10(9)/L). In her leukemic cells we detected the very rare translocation t(7;19)(q35;p13) and LYL1 overexpression. Additionally, we detected submicroscopic deletions at 4q25, 7q33 and 10q23 by oligo-aCGH analysis...
2014: Leukemia Research Reports
https://www.readbyqxmd.com/read/24532287/lung-endothelial-barrier-disruption-in-lyl1-deficient-mice
#15
Nelly Pirot, Hélène Delpech, Virginie Deleuze, Christiane Dohet, Monique Courtade-Saïdi, Céline Basset-Léobon, Elias Chalhoub, Danièle Mathieu, Valérie Pinet
Maturation of newly formed vessels is a multistep phenomenon during which functional endothelial barriers are established. Disruption of vessel integrity is an important feature in many physiological and pathological processes. We previously reported that lymphoblastic leukemia-derived sequence 1 (LYL1) is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. In this study, we show that LYL1 is also required during the formation of the mature endothelial barrier in the lungs of adult mice...
April 15, 2014: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/24465765/lim-domain-only-2-lmo2-induces-t-cell-leukemia-by-two-distinct-pathways
#16
Stephen Smith, Rati Tripathi, Charnise Goodings, Susan Cleveland, Elizabeth Mathias, J Andrew Hardaway, Natalina Elliott, Yajun Yi, Xi Chen, James Downing, Charles Mullighan, Deborah A Swing, Lino Tessarollo, Liqi Li, Paul Love, Nancy A Jenkins, Neal G Copeland, Mary Ann Thompson, Yang Du, Utpal P Davé
The LMO2 oncogene is deregulated in the majority of human T-cell leukemia cases and in most gene therapy-induced T-cell leukemias. We made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer. These transgenic mice developed highly penetrant T-ALL by two distinct patterns of gene expression: one in which there was concordant activation of Lyl1, Hhex, and Mycn or alternatively, with Notch1 target gene activation. Most strikingly, this gene expression clustering was conserved in human Early T-cell Precursor ALL (ETP-ALL), where LMO2, HHEX, LYL1, and MYCN were most highly expressed...
2014: PloS One
https://www.readbyqxmd.com/read/24385720/upregulation-of-t-cell-specific-transcription-factor-expression-in-pediatric-t-cell-acute-lymphoblastic-leukemia-t-all
#17
Müge Sayitoğlu, Yücel Erbilgin, Ozden Hatırnaz Ng, Inci Yıldız, Tiraje Celkan, Sema Anak, Omer Devecioğlu, Gönül Aydoğan, Serap Karaman, Nazan Sarper, Cetin Timur, Umit Ure, Uğur Ozbek
OBJECTIVE: T-cell acute lymphoblastic leukemia (T-ALL) is associated with recurrent chromosomal aberrations andabnormal ectopic gene expression during T-cell development. In order to gain insight into the pathogenesis of T-ALLthis study aimed to measure the level of expression of 7 T-cell oncogenes (LMO2, LYL1, TAL1, TLX1, TLX3, BMI1, andCALM-AF10) in pediatric T-ALL patients Material and Methods: LMO2, LYL1, TLX1, TLX3, BMI1, TAL1, and CALM-AF10 expression was measured usingquantitative real-time PCR in 43 pediatric T-ALL patients...
December 2012: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/24086757/the-t-cell-oncogene-tal2-is-a-target-of-pu-1-and-upregulated-during-osteoclastogenesis
#18
Nadine Courtial, Christian Mücke, Stefanie Herkt, Stephan Kolodziej, Helge Hussong, Jörn Lausen
Transcription factors play a crucial role in regulating differentiation processes during human life and are important in disease. The basic helix-loop-helix transcription factors Tal1 and Lyl1 play a major role in the regulation of gene expression in the hematopoietic system and are involved in human leukemia. Tal2, which belongs to the same family of transcription factors as Tal1 and Lyl1, is also involved in human leukaemia. However, little is known regarding the expression and regulation of Tal2 in hematopoietic cells...
2013: PloS One
https://www.readbyqxmd.com/read/24058671/mutation-of-the-light-induced-yellow-leaf-1-gene-which-encodes-a-geranylgeranyl-reductase-affects-chlorophyll-biosynthesis-and-light-sensitivity-in-rice
#19
Yong Zhou, Zhiyun Gong, Zefeng Yang, Yuan Yuan, Jinyan Zhu, Man Wang, Fuhai Yuan, Shujun Wu, Zhiqin Wang, Chuandeng Yi, Tinghua Xu, MyongChol Ryom, Minghong Gu, Guohua Liang
Chlorophylls (Chls) are crucial for capturing light energy for photosynthesis. Although several genes responsible for Chl biosynthesis were characterized in rice (Oryza sativa), the genetic properties of the hydrogenating enzyme involved in the final step of Chl synthesis remain unknown. In this study, we characterized a rice light-induced yellow leaf 1-1 (lyl1-1) mutant that is hypersensitive to high-light and defective in the Chl synthesis. Light-shading experiment suggested that the yellowing of lyl1-1 is light-induced...
2013: PloS One
https://www.readbyqxmd.com/read/23974199/genome-wide-analysis-of-transcriptional-regulators-in-human-hspcs-reveals-a-densely-interconnected-network-of-coding-and-noncoding-genes
#20
Dominik Beck, Julie A I Thoms, Dilmi Perera, Judith Schütte, Ashwin Unnikrishnan, Kathy Knezevic, Sarah J Kinston, Nicola K Wilson, Tracey A O'Brien, Berthold Göttgens, Jason W H Wong, John E Pimanda
Genome-wide combinatorial binding patterns for key transcription factors (TFs) have not been reported for primary human hematopoietic stem and progenitor cells (HSPCs), and have constrained analysis of the global architecture of molecular circuits controlling these cells. Here we provide high-resolution genome-wide binding maps for a heptad of key TFs (FLI1, ERG, GATA2, RUNX1, SCL, LYL1, and LMO2) in human CD34(+) HSPCs, together with quantitative RNA and microRNA expression profiles. We catalog binding of TFs at coding genes and microRNA promoters, and report that combinatorial binding of all 7 TFs is favored and associated with differential expression of genes and microRNA in HSPCs...
October 3, 2013: Blood
keyword
keyword
67612
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"