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Double edged sword

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https://www.readbyqxmd.com/read/28078624/millipede-defensive-compounds-are-a-double-edged-sword-natural-history-of-the-millipede-parasitic-genus-myriophora-brown-diptera-phoridae
#1
John M Hash, Jocelyn G Millar, John M Heraty, James F Harwood, Brian V Brown
Toxic defensive secretions produced by millipedes in the orders Julida, Spirobolida, Spirostreptida, and Polydesmida are highly repellent to most vertebrate and invertebrate natural enemies, but a few insects have evolved mechanisms to overcome these defenses. We demonstrate that highly specialized parasitic phorid flies in the species-rich genus Myriophora use volatile millipede defensive compounds as kairomones for host location. Of the two predominant quinone components in the defensive blend of juliform millipedes, 2-methoxy-3-methyl-1,4-benzoquinone alone was sufficient to attract adult flies of both sexes; however, a combination of 2-methoxy-3-methyl-1,4-benzoquinone and 2-methyl-1,4-benzoquinone increased attractiveness nearly threefold...
January 11, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28063580/investigation-into-ethylene-oxide-treatment-and-residuals-on-dna-and-downstream-dna-analysis
#2
L Wilson-Wilde, D Yakovchyts, S Neville, P Maynard, P Gunn
Recent years have seen a significant increase in the sensitivity of DNA testing, enabling the determination of DNA profiles from low levels of cellular material. However, the increased sensitivity is in many ways a double-edged sword as background contaminating DNA generated during the manufacture of consumables and sampling devices is now being detected and may compromise the interpretation of the DNA profile results. This study initially demonstrated the effectiveness of ethylene oxide (EO) as a post-production treatment to eliminate DNA on swabs, used as a sampling device for the recovery of cellular material...
January 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28062457/the-microvasculature-the-next-battlefield-where-transforming-growth-factor-%C3%AE-and-endoglin-draw-their-double-edged-swords
#3
EDITORIAL
Gerard Pasterkamp, Marie José Goumans
No abstract text is available yet for this article.
January 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28054715/tubal-origin-of-ovarian-cancer-the-double-edged-sword-of-haemoglobin
#4
Shiou-Fu Lin, Emily Gerry, Ie-Ming Shih
Ovarian high-grade serous carcinoma (HGSC) is the most malignant neoplasm of the gynaecologic tract. While the origins of many human malignant neoplasms are clear, the origin of HGSC remains poorly understood. This lack of knowledge limits our understanding of its pathogenesis and compromises efforts devoted to develop better early detection tools and effective preventative intervention. The tubal origin of HGSC has been put forward since the initial report of dysplastic lesions (now known as serous tubal intraepithelial carcinomas, or STICs) that morphologically resemble HGSC in the fallopian tube...
January 5, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28040558/complement-in-autoimmune-diseases
#5
REVIEW
Pandiarajan Vignesh, Amit Rawat, Madhubala Sharma, Surjit Singh
The complement system is an ancient and evolutionary conserved element of the innate immune mechanism. It comprises of more than 20 serum proteins most of which are synthesized in the liver. These proteins are synthesized as inactive precursor proteins which are activated by appropriate stimuli. The activated forms of these proteins act as proteases and cleave other components successively in amplification pathways leading to exponential generation of final effectors. Three major pathways of complement pathways have been described, namely the classical, alternative and lectin pathways which are activated by different stimuli...
December 28, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28035578/the-bax-gene-as-a-candidate-for-negative-autophagy-related-genes-regulator-on-mrna-levels-in-colorectal-cancer
#6
Justyna Gil, David Ramsey, Elzbieta Szmida, Przemyslaw Leszczynski, Pawel Pawlowski, Marek Bebenek, Maria M Sasiadek
Autophagy is a catabolic process, which is involved in the maintenance of intracellular homeostasis by degrading redundant molecules and organelles. Autophagy begins with the formation of a double-membrane phagophore, followed by its enclosure, thus leading to the appearance of an autophagosome which fuses with lysosome. This process is highly conserved, precisely orchestrated and regulated by autophagy-related genes. Recently, autophagy has been widely studied in different types of cancers, including colorectal cancer...
February 2017: Medical Oncology
https://www.readbyqxmd.com/read/28018315/addressing-the-antibiotic-resistance-problem-with-probiotics-reducing-the-risk-of-its-double-edged-sword-effect
#7
REVIEW
Ivan C V J Imperial, Joyce A Ibana
Antibiotic resistance is a global public health problem that requires our attention. Indiscriminate antibiotic use is a major contributor in the introduction of selective pressures in our natural environments that have significantly contributed in the rapid emergence of antibiotic-resistant microbial strains. The use of probiotics in lieu of antibiotic therapy to address certain health conditions in both animals and humans may alleviate these antibiotic-mediated selective pressures. Probiotic use is defined as the actual application of live beneficial microbes to obtain a desired outcome by preventing diseased state or improving general health...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28008145/msh2-brca1-expression-as-a-dna-repair-signature-predicting-survival-in-early-stage-lung-cancer-patients-from-the-ifct-0002-phase-3-trial
#8
Guénaëlle Levallet, Fatéméh Dubois, Pierre Fouret, Martine Antoine, Solenn Brosseau, Emmanuel Bergot, Michèle Beau-Faller, Valérie Gounant, Elisabeth Brambilla, Didier Debieuvre, Olivier Molinier, Françoise Galateau-Sallé, Julien Mazieres, Elisabeth Quoix, Jean-Louis Pujol, Denis Moro-Sibilot, Alexandra Langlais, Franck Morin, Virginie Westeel, Gérard Zalcman
INTRODUCTION: DNA repair is a double-edged sword in lung carcinogenesis. When defective, it promotes genetic instability and accumulated genetic alterations. Conversely these defects could sensitize cancer cells to therapeutic agents inducing DNA breaks. METHODS: We used immunohistochemistry (IHC) to assess MSH2, XRCC5, and BRCA1 expression in 443 post-chemotherapy specimens from patients randomized in a Phase 3 trial, comparing two neoadjuvant regimens in 528 Stage I-II non-small cell lung cancer (NSCLC) patients (IFCT-0002)...
December 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/28005423/cellular-senescence-and-lung-function-during-aging-yin-and-yang
#9
Judith Campisi
Cellular senescence is a cell fate decision and stress response that entails a permanent arrest of cell proliferation coupled to a complex secretory phenotype. Senescent cells increase in number with age in most, if not all, mammalian tissues, including the airways and lungs. They also increase at greater than expected numbers, compared with age-matched controls, at sites of age-related pathologies such as chronic obstructive pulmonary disorder and emphysema. The senescence response is a double-edged sword...
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28003000/double-edge-sword-behavior-of-carbendazim-a-potent-fungicide-with-anti-cancer-therapeutic-properties
#10
Karan Goyal, Ajay Sharma, Ridhima Arya, Rohit Sharma, Girish K Gupta, Anil K Sharma
A number of benzimidazole derivatives such as benomyl and carbendazim have been known for their potential role as agricultural fungicides. Simultaneously carbendazim has also been found to inhibit proliferation of mammalian tumor cells specifically drug and multidrug resistant cell lines. Studies carried out with fungal and mammalian cells have highlighted the potential role of carbendazim in inhibiting proliferation of cells, thereby exhibiting therapeutic implications against cancer. Because of its promising preclinical antitumor activity, Carbendazim had undergone phase I clinical trials and is under further clinical investigations for treatment of cancer...
December 21, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27999651/destructive-effect-of-quinone-containing-compounds-on-cytochrome-p450-arbutin-as-a-double-edged-sword
#11
Ahmad Karkhah
No abstract text is available yet for this article.
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27978799/topoisomerases-and-anthracyclines-recent-advances-and-perspectives-in-anticancer-therapy-and-prevention-of-cardiotoxicity
#12
Alvaro Mordente, Elisabetta Meucci, Giuseppe Ettore Martorana, Daniela Tavian, Andrea Silvestrini
Topoisomerases are ubiquitous enzymes involved in maintaining genomic stability of the cell by regulating the over- or underwinding of DNA strands. Besides their customary functions, topoisomerases are important cellular targets of widely used anticancer drugs. In particular, topoisomerase IIα(Top2α) has been postulated as the primary molecular target of anthracycline's anticancer activity, whereas topoisomerase II β (Top2β), the only Top2 present in heart tissue, seems to be involved into the development of anthracycline-induced cardiotoxicity...
December 14, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27935231/prolonged-tacrolimus-use-for-pediatric-gastrointestinal-disorder-a-double-edged-sword
#13
Kenji Hosoi, Katsuhiro Arai, Kentaro Matsuoka, Hirotaka Shimizu, Koichi Kamei, Atsuko Nakazawa, Toshiaki Shimizu, Julian Tang, Shuichi Ito
BACKGROUND: Although tacrolimus (TAC) appeared useful in inducing remission in children with refractory inflammatory bowel disease (IBD) or autoimmune gastroenteropathy (AGE), its use in maintenance therapy remains controversial. The aim of this study was to reveal the potential nephrotoxic nature of prolonged TAC use. METHODS: This retrospective study reviews children with gastrointestinal disorder who underwent kidney biopsy for the evaluation of renal damage during TAC therapy of over one year...
December 9, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27913455/inherited-thrombophilia-a-double-edged-sword
#14
Saskia Middeldorp
Inherited thrombophilia is a blood coagulation disorder that increases the risk for venous thromboembolism (VTE). During the last decades, the practice of testing has evolved from testing selected populations, leading to high perceived risks, to broad testing for various conditions that included VTE, arterial thrombosis, and pregnancy complications. Because results of such tests usually do not guide treatment decisions, not testing patients with VTE for inherited thrombophilia is on the "Choosing Wisely" list endorsed by multiple specialty societies, including ASH...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27894811/critical-role-of-toll-like-receptors-in-pathophysiology-of-allergic-asthma
#15
Seyyed Shamsadin Athari, Seyyede Masoume Athari, Fateme Beyzay, Masoud Movassaghi, Esmaeil Mortaz, Mehdi Taghavi
Allergic asthma is an airway disease, characterized by reversible bronchoconstriction, chronic inflammation of the airway, and thickness of smooth muscle in the respiratory tract. Asthma is orchestrated by an excessive Th2-adaptive immune response, in which innate immunity plays a key role. Recently TLRs have received more and more attention as they are central to orchestrate the innate immune responses. TLRs are localized as integral membrane or intracellular glycoproteins with those on the cell surface sensing microbial antigens and the ones, localized in intracellular vesicles, sensing microbial nucleic acid species...
November 26, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27894168/hysteroscopy-in-fertility-sparing-management-for-early-endometrial-cancer-a-double-edged-sword
#16
EDITORIAL
Jeong Yeol Park
No abstract text is available yet for this article.
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27877085/the-evolving-functions-of-autophagy-in-ocular-health-a-double-edged-sword
#17
REVIEW
Peiwei Chai, Hongyan Ni, He Zhang, Xianqun Fan
Autophagy plays an adaptive role in cell survival, development, differentiation and intracellular homeostasis. Autophagy is recognized as a 'self-cannibalizing' process that is active during stresses such as starvation, chemotherapy, infection, ageing, and oxygen shortage to protect organisms from various irritants and to regenerate materials and energy. However, autophagy can also lead to a form of programmed cell death distinct from apoptosis. Components of the autophagic pathway are constitutively expressed at a high level in the eye, including in the cornea, lens, retina, and orbit...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27872329/are-antidepressants-a-double-edged-sword-treatment-emergent-affective-switch-or-antidepressant-discontinuation-syndrome
#18
Neelya Agalawatta, Cornelia Kaufmann, Yulisha Byrow, Nicole Burston, William Lyndon, Gin S Malhi
No abstract text is available yet for this article.
November 20, 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/27869157/dna-repair-rna-dna-hybrids-a-double-edged-sword-in-genomic-stability
#19
Paulina Strzyz
No abstract text is available yet for this article.
November 21, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27867192/dna-repair-rna-dna-hybrids-double-edged-swords
#20
Denise Waldron
No abstract text is available yet for this article.
January 2017: Nature Reviews. Genetics
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