keyword
MENU ▼
Read by QxMD icon Read
search

Double edged sword

keyword
https://www.readbyqxmd.com/read/28222444/inflammation-a-double-edged-sword-in-the-response-to-pseudomonas-aeruginosa-infection
#1
Christina K Lin, Barbara I Kazmierczak
The Gram-negative opportunistic pathogen Pseudomonas aeruginosa exploits failures of barrier defense and innate immunity to cause acute infections at a range of anatomic sites. We review the defense mechanisms that normally protect against P. aeruginosa pulmonary infection, as well as the bacterial products and activities that trigger their activation. Innate immune recognition of P. aeruginosa is critical for pathogen clearance; nonetheless, inflammation is also associated with pathogen persistence and poor host outcomes...
February 22, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28219180/-advances-in-effect-of-unilateral-auditory-deprivation-on-sound-localization
#2
J F Liu, J S Dai, N Y Wang
In patients with single-sided deafness (SSD), the interaural time difference and the interaural level difference signals are insufficient or missing, which result in the lack of sound localization ability and the decrease of speech comprehension in the noise environments. SSD can also cause the morphological and functional changes of the central auditory system, resulting in auditory deprivation. In early stage of the development, the auditory center is more susceptible to ambient environment and auditory inputs...
February 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28197000/impact-of-an-educational-module-in-antidepressant-naive-patients-prescribed-antidepressants-for-depression-pilot-proof-of-concept-randomized-controlled-trial
#3
Annie P John, Nagendra Madan Singh, Nagarajaiah, Chittaranjan Andrade
BACKGROUND: Patients are educated about their illness and its treatment at the time of diagnosis. However, little is known about how much of this education is retained and how it influences knowledge about, attitudes toward, and experiences with medication in antidepressant-naive patients with depression. METHODS: Antidepressant-naive outpatients with International Classification of Diseases-10 dysthymia or mild to moderate depression, who were advised antidepressant monotherapy, were randomized to control (n = 22) or intervention (n = 17) groups...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28193596/vegf-regulates-hippocampal-neurogenesis-and-reverses-cognitive-deficits-in-immature-rats-after-status-epilepticus-through-the-vegf-r2-signaling-pathway
#4
Wei Han, Xiaojie Song, Rong He, Tianyi Li, Li Cheng, Lingling Xie, Hengsheng Chen, Li Jiang
Epilepsy is the most common chronic disease in children, who exhibit a higher risk for status epilepticus (SE) than adults. Hippocampal neurogenesis is altered by epilepsy, particularly in the immature brain, which may influence cognitive development. Vascular endothelial growth factor (VEGF) represents an attractive target to modulate brain function at the neurovascular interface and is a double-edged sword in seizures. We used the lithium-pilocarpine-induced epilepsy model in immature Sprague-Dawley rats to study the effects of VEGF on hippocampal neurogenesis in the acute phase and on long-term cognitive behaviors in immature rats following status epilepticus (SE)...
February 10, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28191680/friends-or-foes-host-defense-antimicrobial-peptides-and-proteins-in-human-skin-diseases
#5
REVIEW
François Niyonsaba, Chanisa Kiatsurayanon, Panjit Chieosilapatham, Hideoki Ogawa
Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28188387/quercetin-induces-protective-autophagy-and-apoptosis-through-er-stress-via-the-p-stat3-bcl-2-axis-in-ovarian-cancer
#6
Y Liu, W Gong, Z Y Yang, X S Zhou, C Gong, T R Zhang, X Wei, D Ma, F Ye, Q L Gao
Quercetin (3,3',4',5,7-pentahydroxyflavone, Qu) is a promising cancer chemo-preventive agent for various cancers because it inhibits disease progression and promotes apoptotic cell death. In our previous study, we demonstrated that Qu could evoke ER stress to enhance drug cytotoxicity in ovarian cancer (OC). However, Qu-induced ER stress in OC is still poorly understood. Here, we demonstrated that Qu evoked ER stress to involve in mitochondria apoptosis pathway via the p-STAT3/Bcl-2 axis in OC cell lines and in primary OC cells...
April 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28188219/distinct-effects-of-mir-210-reduction-on-neurogenesis-increased-neuronal-survival-of-inflammation-but-reduced-proliferation-associated-with-mitochondrial-enhancement
#7
Ludmila A Voloboueva, Xiaoyun Sun, Lijun Xu, Yi-Bing Ouyang, Rona G Giffard
Neurogenesis is essential to brain development, and plays a central role in the response to brain injury. Stroke and head trauma stimulate proliferation of endogenous neural stem cells (NSC). However, the survival of young neurons is sharply reduced by post-injury inflammation. Cellular mitochondria are critical to successful neurogenesis and are a major target of inflammatory injury. Mitochondrial protection was shown to improve survival of young neurons. This study tested whether reducing cellular microRNA-210 (miR-210) would enhance mitochondrial function and improve survival of young murine neurons under inflammatory conditions...
February 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28187286/endogenous-dna-damage-as-a-source-of-genomic-instability-in-cancer
#8
REVIEW
Anthony Tubbs, André Nussenzweig
Genome instability, defined as higher than normal rates of mutation, is a double-edged sword. As a source of genetic diversity and natural selection, mutations are beneficial for evolution. On the other hand, genomic instability can have catastrophic consequences for age-related diseases such as cancer. Mutations arise either from inactivation of DNA repair pathways or in a repair-competent background due to genotoxic stress from celluar processes such as transcription and replication that overwhelm high-fidelity DNA repair...
February 9, 2017: Cell
https://www.readbyqxmd.com/read/28186825/balancing-safety-and-harm-for-older-adults-with-dementia-in-rural-emergency-departments-healthcare-professionals-perspectives
#9
Kathleen F Hunter, Belinda Parke, Maureen Babb, Dorothy Forbes, Laurel Strain
INTRODUCTION: The emergency department (ED) is a potentially harmful environment for older adults with dementia, and rural EDs face unique challenges in providing care to this population. The purpose of this study was to understand safety and harm in rural ED transitional care for community dwelling older adults with dementia from the perspective of healthcare professionals (HCPs). METHODS: An interpretive, descriptive exploratory design from a social ecological perspective was used...
January 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28179109/mechanisms-of-defense-against-products-of-cysteine-catabolism-in-the-nematode-caenorhabditis-elegans
#10
Leonid Livshits, Arijit Kumar Chatterjee, Netanel Karbian, Rachel Abergel, Zohar Abergel, Einav Gross
Cysteine catabolism presents cells with a double-edged sword. On the one hand, cysteine degradation provides cells with essential molecules such as taurine and sulfide. The formation of sulfide in cells is thought to regulate important and diverse physiological processes including blood circulation, synaptic activity and inflammation. On the other hand, the catabolism of cysteine by gut microbiota can release high levels of sulfide that may underlie the development or relapse of ulcerative colitis, an inflammatory bowel disease affecting millions of people worldwide...
March 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28174306/a-mobile-element-in-muts-drives-hypermutation-in-a-marine-vibrio
#11
Nathaniel D Chu, Sean A Clarke, Sonia Timberlake, Martin F Polz, Alan D Grossman, Eric J Alm
: Bacteria face a trade-off between genetic fidelity, which reduces deleterious mistakes in the genome, and genetic innovation, which allows organisms to adapt. Evidence suggests that many bacteria balance this trade-off by modulating their mutation rates, but few mechanisms have been described for such modulation. Following experimental evolution and whole-genome resequencing of the marine bacterium Vibrio splendidus 12B01, we discovered one such mechanism, which allows this bacterium to switch to an elevated mutation rate...
February 7, 2017: MBio
https://www.readbyqxmd.com/read/28163971/solving-the-puzzle-what-is-behind-our-forefathers-anti-inflammatory-remedies
#12
REVIEW
Javier Rodriguez Villanueva, Jorge Martín Esteban, Laura Rodríguez Villanueva
Inflammation is a ubiquitous host response in charge of restoring normal tissue structure and function but is a double-edged sword, as the uncontrolled or excessive process can lead to the injury of host cells, chronic inflammation, chronic diseases, and also neoplastic transformation. Throughout history, a wide range of species has been claimed to have anti-inflammatory effects worldwide. Among them, Angelica sinensis, Tropaeolum majus, Castilleja tenuiflora, Biophytum umbraculum, to name just a few, have attracted the scientific and general public attention in the last years...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28154550/peri-hemorrhagic-edema-and-secondary-hematoma-expansion-after-intracerebral-hemorrhage-from-benchwork-to-practical-aspects
#13
REVIEW
Marc-Alain Babi, Michael L James
Spontaneous intracerebral hemorrhage (SICH) is the most lethal type of stroke. Half of these deaths occur within the acute phase. Frequently observed deterioration during the acute phase is often due to rebleeding or peri-hematomal expansion. The exact pathogenesis that leads to rebleeding or peri-hemorrhagic edema remains under much controversy. Numerous trials have investigated potential predictor of peri-hemorrhagic edema formation or rebleeding but have yet to come with consistent results. Unfortunately, almost all of the "classical" approaches have failed to show a significant impact in regard of significant clinical outcome in randomized clinical trials...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28153605/cd19-from-bench-to-bedside
#14
REVIEW
Xinchen Li, Ying Ding, Mengting Zi, Li Sun, Wenjie Zhang, Shun Chen, Yuekang Xu
As a 95-kDa member of the immunoglobulin super-family expressed exclusively on B lymphocytes, CD19 is a critical co-receptor for B cell antigen receptor (BCR) signal transduction. Co-ligation of CD19 with the BCR synergistically enhances calcium release, mitogen-activated protein kinase activity and cell proliferation. However, CD19 deficient animals also display hyper-responsiveness under certain circumstances, indicating potential negative regulatory functions in BCR signaling. Thus CD19, like many other signaling molecules, is a double-edged sword and its abnormal expression can result in B cell related diseases...
March 2017: Immunology Letters
https://www.readbyqxmd.com/read/28150228/personalizing-mechanical-ventilation-according-to-physiologic-parameters-to-stabilize-alveoli-and-minimize-ventilator-induced-lung-injury-vili
#15
REVIEW
Gary F Nieman, Joshua Satalin, Penny Andrews, Hani Aiash, Nader M Habashi, Louis A Gatto
It has been shown that mechanical ventilation in patients with, or at high-risk for, the development of acute respiratory distress syndrome (ARDS) can be a double-edged sword. If the mechanical breath is improperly set, it can amplify the lung injury associated with ARDS, causing a secondary ventilator-induced lung injury (VILI). Conversely, the mechanical breath can be adjusted to minimize VILI, which can reduce ARDS mortality. The current standard of care ventilation strategy to minimize VILI attempts to reduce alveolar over-distension and recruitment-derecruitment (R/D) by lowering tidal volume (Vt) to 6 cc/kg combined with adjusting positive-end expiratory pressure (PEEP) based on a sliding scale directed by changes in oxygenation...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28126343/management-of-impulse-control-disorders-with-deep-brain-stimulation-a-double-edged-sword
#16
REVIEW
Chayut Kasemsuk, Genko Oyama, Nobutaka Hattori
Deep brain stimulation (DBS) is a surgical option for advanced Parkinson's disease. Although DBS is used to treat motor fluctuation, DBS may affect non-motor symptoms including mood disorders, cognitive dysfunction, and behavior problems. Impulse control disorders (ICDs) are abnormal behaviors with various manifestations such as pathological gambling, hypersexuality, compulsive shopping, and binge eating, which can affect the quality of life in patients with Parkinson's disease. The effect of DBS on ICD is controversial...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28120802/androgens-predict-parasitism-in-female-meerkats-a-new-perspective-on-a-classic-trade-off
#17
Kendra N Smyth, Lydia K Greene, Tim Clutton-Brock, Christine M Drea
The immunocompetence handicap hypothesis posits that androgens in males can be a 'double-edged sword', actively promoting reproductive success, while also negatively impacting health. Because there can be both substantial androgen concentrations in females and significant androgenic variation among them, particularly in species portraying female social dominance over males or intense female-female competition, androgens might also play a role in mediating female health and fitness. We examined this hypothesis in the meerkat (Suricata suricatta), a cooperatively breeding, social carnivoran characterized by aggressively mediated female social dominance and extreme rank-related reproductive skew...
October 2016: Biology Letters
https://www.readbyqxmd.com/read/28108140/steroid-treatment-in-ocular-tuberculosis-a-double-edged-sword
#18
S Souissi, T David, L Beral
INTRODUCTION: We report the case of a Caribbean patient with an atypical presentation of bilateral tuberculous chorioretinopathy. PATIENT AND METHODS: A 57-year-old woman, with hypertension and non-insulin dependent diabetes, was referred to our center for a sudden loss of vision in the right eye to hand motions. Ophthalmic examination revealed only right papilledema. Brain magnetic resonance imaging was normal. Laboratory examination revealed no signs of inflammation...
January 17, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28105558/immunology-of-bee-venom
#19
REVIEW
Daniel Elieh Ali Komi, Farzaneh Shafaghat, Ricardo D Zwiener
Bee venom is a blend of biochemicals ranging from small peptides and enzymes to biogenic amines. It is capable of triggering severe immunologic reactions owing to its allergenic fraction. Venom components are presented to the T cells by antigen-presenting cells within the skin. These Th2 type T cells then release IL-4 and IL-13 which subsequently direct B cells to class switch to production of IgE. Generating venom-specific IgE and crosslinking FcεR1(s) on the surface of mast cells complete the sensitizing stage in allergic individuals who are most likely to experience severe and even fatal allergic reactions after being stung...
January 20, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28104072/autonomic-tone-and-atrial-fibrillation-a%C3%A2-double-edged-sword
#20
EDITORIAL
Jeffrey J Goldberger, Raul D Mitrani
No abstract text is available yet for this article.
January 24, 2017: Journal of the American College of Cardiology
keyword
keyword
67608
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"