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https://www.readbyqxmd.com/read/27913455/inherited-thrombophilia-a-double-edged-sword
#1
Saskia Middeldorp
Inherited thrombophilia is a blood coagulation disorder that increases the risk for venous thromboembolism (VTE). During the last decades, the practice of testing has evolved from testing selected populations, leading to high perceived risks, to broad testing for various conditions that included VTE, arterial thrombosis, and pregnancy complications. Because results of such tests usually do not guide treatment decisions, not testing patients with VTE for inherited thrombophilia is on the "Choosing Wisely" list endorsed by multiple specialty societies, including ASH...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27894811/critical-role-of-toll-like-receptors-in-pathophysiology-of-allergic-asthma
#2
Seyyed Shamsadin Athari, Seyyede Masoume Athari, Fateme Beyzay, Masoud Movassaghi, Esmaeil Mortaz, Mehdi Taghavi
Allergic asthma is an airway disease, characterized by reversible bronchoconstriction, chronic inflammation of the airway, and thickness of smooth muscle in the respiratory tract. Asthma is orchestrated by an excessive Th2-adaptive immune response, in which innate immunity plays a key role. Recently TLRs have received more and more attention as they are central to orchestrate the innate immune responses. TLRs are localized as integral membrane or intracellular glycoproteins with those on the cell surface sensing microbial antigens and the ones, localized in intracellular vesicles, sensing microbial nucleic acid species...
November 26, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27894168/hysteroscopy-in-fertility-sparing-management-for-early-endometrial-cancer-a-double-edged-sword
#3
EDITORIAL
Jeong Yeol Park
No abstract text is available yet for this article.
November 17, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27877085/the-evolving-functions-of-autophagy-in-ocular-health-a-double-edged-sword
#4
REVIEW
Peiwei Chai, Hongyan Ni, He Zhang, Xianqun Fan
Autophagy plays an adaptive role in cell survival, development, differentiation and intracellular homeostasis. Autophagy is recognized as a 'self-cannibalizing' process that is active during stresses such as starvation, chemotherapy, infection, ageing, and oxygen shortage to protect organisms from various irritants and to regenerate materials and energy. However, autophagy can also lead to a form of programmed cell death distinct from apoptosis. Components of the autophagic pathway are constitutively expressed at a high level in the eye, including in the cornea, lens, retina, and orbit...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27872329/are-antidepressants-a-double-edged-sword-treatment-emergent-affective-switch-or-antidepressant-discontinuation-syndrome
#5
Neelya Agalawatta, Cornelia Kaufmann, Yulisha Byrow, Nicole Burston, William Lyndon, Gin S Malhi
No abstract text is available yet for this article.
November 20, 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/27869157/dna-repair-rna-dna-hybrids-a-double-edged-sword-in-genomic-stability
#6
Paulina Strzyz
No abstract text is available yet for this article.
November 21, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27867192/dna-repair-rna-dna-hybrids-double-edged-swords
#7
Denise Waldron
No abstract text is available yet for this article.
November 21, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27863886/cognitive-control-as-a-double-edged-sword
#8
REVIEW
Tarek Amer, Karen L Campbell, Lynn Hasher
Cognitive control, the ability to limit attention to goal-relevant information, aids performance on a wide range of laboratory tasks. However, there are many day-to-day functions which require little to no control and others which even benefit from reduced control. We review behavioral and neuroimaging evidence demonstrating that reduced control can enhance the performance of both older and, under some circumstances, younger adults. Using healthy aging as a model, we demonstrate that decreased cognitive control benefits performance on tasks ranging from acquiring and using environmental information to generating creative solutions to problems...
December 2016: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/27863349/trpv1-channels-in-cardiovascular-system-a-double-edged-sword
#9
REVIEW
Puneet Kaur Randhawa, Amteshwar Singh Jaggi
Apart from modulating nociception, there is vital role of TRPV1 channels in modulating atherosclerosis, congestive heart failure, systemic hypertension, pulmonary hypertension, hemorrhagic shock and vascular remodeling. TRPV1 channel activation has shielding effect against the development of atherosclerosis and systemic hypertension. TRPV1 channel activation alleviates the formation of atherosclerotic lesions via increasing the expression of cholesterol efflux regulatory protein, UCP 2 and enhancing autophagy...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27861814/local-groundwater-withdrawal-permitting-laws-in-the-south-western-u-s-california-in-comparative-context
#10
Rebecca Louise Nelson, Debra Perrone
The Sustainable Groundwater Management Act (SGMA) aims to control, for the first time in California's history, the state's significant use and depletion of groundwater. SGMA gives local agencies a high degree of discretion in relation to a new permitting power, but the discretion is a double-edged sword: agencies gain maximum flexibility to tailor their regime to local conditions, yet the statute provides no direction on appropriate components of a groundwater permitting regime. We introduce SGMA and the broader legislative context to its permitting power, and we explain the continuing common law context in which the legislation operates...
November 10, 2016: Ground Water
https://www.readbyqxmd.com/read/27847552/schisandrin-b-a-double-edged-sword-in-nonalcoholic-fatty-liver-disease
#11
REVIEW
Pou Kuan Leong, Kam Ming Ko
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver lesions ranging from hepatic steatosis, nonalcoholic steatohepatitis, hepatic cirrhosis, and hepatocellular carcinoma. The high global prevalence of NAFLD has underlined the important public health implications of this disease. The pathogenesis of NAFLD involves the abnormal accumulation of free fatty acids, oxidative stress, endoplasmic reticulum (ER) stress, and a proinflammatory state in the liver. Schisandrin B (Sch B), an active dibenzooctadiene lignan isolated from the fruit of Schisandra chinensis (a traditional Chinese herb), was found to possess antihyperlipidemic, antioxidant, anti-ER stress, and anti-inflammatory activities in cultured hepatocytes in vitro and in rodent livers in vivo...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27829708/interleukin-22-might-act-as-a-double-edged-sword-in-type-2-diabetes-and-coronary-artery-disease
#12
Fangchen Gong, Jin Wu, Ping Zhou, Mengyao Zhang, Jingning Liu, Ying Liu, Xiang Lu, Zhengxia Liu
Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are both characterized by chronic low-grade inflammation. The role of Th17 and its related cytokines in T2DM and CAD is unclear. Here we investigated the serum levels of five Th17-related cytokines (IL-17, IL-22, MIP-3α, IL-9, and IL-27) in T2DM, CAD, and T2DM-CAD comorbidity patients. IL-22 was found to be elevated in all three conditions. Elevated serum IL-22 was independently associated with the incidence of T2DM and CAD. Conversely, IL-22 was found to protect endothelial cells from glucose- and lysophosphatidylcholine- (LPC-) induced injury, and IL-22R1 expression on endothelial cells was increased upon treatment with high glucose and LPC...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27829171/metal-ions-influx-is-a-double-edged-sword-for-the-pathogenesis-of-alzheimer-s-disease
#13
REVIEW
Pu Wang, Zhan-You Wang
Alzheimer's disease (AD) is a common form of dementia in aged people, which is defined by two pathological characteristics: β-amyloid protein (Aβ) deposition and tau hyperphosphorylation. Although the mechanisms of AD development are still being debated, a series of evidence supports the idea that metals, such as copper, iron, zinc, magnesium and aluminium, are involved in the pathogenesis of the disease. In particular, the processes of Aβ deposition in senile plaques (SP) and the inclusion of phosphorylated tau in neurofibrillary tangles (NFTs) are markedly influenced by alterations in the homeostasis of the aforementioned metal ions...
November 6, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27824512/hypoxia-a-double-edged-sword-in-cancer-therapy
#14
Hamed Manoochehri Khoshinani, Saeid Afshar, Rezvan Najafi
Hypoxia is a common feature of malignant tumors. There is an interactive connection between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis. Therefore, tumor hypoxia has been considered as a validated target for treating cancer. This review focuses on the role of hypoxia on chemoresistance and radioresistance. In addition, we address several approaches targeting tumor hypoxia, known as hypoxia-targeted therapy.
November 25, 2016: Cancer Investigation
https://www.readbyqxmd.com/read/27822264/hepatitis-b-and-its-relationship-with-oxidative-stress
#15
REVIEW
Seyed Moayed Alavian, Alireza Showraki
CONTEXT: Despite the great breakthroughs we have witnessed in the last 50 years in the prevention, diagnosis, and treatment of hepatitis B, we are still far from eradicating or even curing the disease. Achieving further progress in controlling this disease will not be possible without discovering the exact pathogenesis behind it. One prime suspect in the pathogenesis of various diseases is oxidative stress. This review will exclusively explore hepatitis B in the context of oxidative stress to obtain a more comprehensive clinical perspective on its pathogenesis and eventual medical therapy...
September 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27814599/the-bad-the-good-and-eif3e-int6
#16
Julie Sesen, Joshua Casaos, Sarah J Scotland, Cathy Seva, T S Karin Eisinger-Mathason, Nicolas Skuli
Recent research on translation and protein synthesis in several pathologies, including cancer, peripheral artery disease, and wound healing, demonstrates the key role played by translational factors in tumorigenic and angiogenic processes. This review will focus on one specific translational factor, eIF3e also called INT6, the "e" subunit of the translation initiation factor eIF3. INT6/eIF3e has recently been described as a multifunction protein playing a role in translation, protein degradation, DNA repair, nonsense-mediated mRNA decay, cell cycle and control of cell response to low oxygen (hypoxia or ischemia) through modulation of the Hypoxia Inducible Factors (HIFs)...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27806313/recombinant-oncolytic-poliovirus-pvsripo-has-potent-cytotoxic-and-innate-inflammatory-effects-mediating-therapy-in-human-breast-and-prostate-cancer-xenograft-models
#17
Eda K Holl, Michael C Brown, David Boczkowski, Megan A McNamara, Daniel J George, Darell D Bigner, Matthias Gromeier, Smita K Nair
Intratumoral inoculation of viruses with tumor-selective cytotoxicity may induce cancer cell death and, thereby, shrink neoplastic lesions. It is unlikely, however, that viral tumor cell killing alone could produce meaningful, durable clinical responses, as clinically suitable 'oncolytic' viruses are severely attenuated and their spread and propagation are opposed by host immunity. Thus, a more propitious event in this context is the innate antiviral response to intratumoral virus administration, in particular for recruiting durable adaptive immune effector responses...
October 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27793031/mir-31-affects-colorectal-cancer-cells-by-inhibiting-autophagy-in-cancer-associated-fibroblasts
#18
Xiaodong Yang, Xiaohui Xu, Junjia Zhu, Shuyu Zhang, Yong Wu, Yongyou Wu, Kui Zhao, Chungen Xing, Jianping Cao, Hong Zhu, Ming Li, Zhenyu Ye, Wei Peng
Autophagy is a double-edged sword in tumor development. Recent studies have found that miRNAs have an inhibitory effect on the regulation of autophagy. It has been reported that miR-31 plays an important role in the development of colorectal cancer. However, what role miR-31 plays in colorectal cancer-associated fibroblasts (CAFs) has not been determined. In this study, we confirmed that the expression of miR-31 in CAFs was higher than in normal colorectal fibroblasts (NFs). We also found that treatment of CAFs with miR-31 mimic inhibited the expression of the autophagy-related genes Beclin-1, ATG, DRAM and LC3...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27791458/store-operated-calcium-entry-activated-autophagy-protects-epc-proliferation-via-the-camkk2-mtor-pathway-in-ox-ldl-exposure
#19
Jie Yang, Jie Yu, Dongdong Li, Sanjiu Yu, Jingbin Ke, Lianyou Wang, Yanwei Wang, Youzhu Qiu, Xubin Gao, Jihang Zhang, Lan Huang
Improving biological functions of endothelial progenitor cells (EPCs) is beneficial to maintaining endothelium homeostasis and promoting vascular re-endothelialization. Because macroautophagy/autophagy has been documented as a double-edged sword in cell functions, its effects on EPCs remain to be elucidated. This study was designed to explore the role and molecular mechanisms of store-operated calcium entry (SOCE)-activated autophagy in proliferation of EPCs under hypercholesterolemia. We employed oxidized low-density lipoprotein (ox-LDL) to mimic hypercholesterolemia in bone marrow-derived EPCs from rat...
October 28, 2016: Autophagy
https://www.readbyqxmd.com/read/27790058/inflammation-after-ischemic-stroke-the-role-of-leukocytes-and-glial-cells
#20
REVIEW
Jong Youl Kim, Joohyun Park, Ji Young Chang, Sa-Hyun Kim, Jong Eun Lee
The immune response after stroke is known to play a major role in ischemic brain pathobiology. The inflammatory signals released by immune mediators activated by brain injury sets off a complex series of biochemical and molecular events which have been increasingly recognized as a key contributor to neuronal cell death. The primary immune mediators involved are glial cells and infiltrating leukocytes, including neutrophils, monocytes and lymphocyte. After ischemic stroke, activation of glial cells and subsequent release of pro- and anti-inflammatory signals are important for modulating both neuronal cell damage and wound healing...
October 2016: Experimental Neurobiology
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