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Double edged sword

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https://www.readbyqxmd.com/read/28934277/double-edged-sword-of-interdisciplinary-knowledge-flow-from-hard-sciences-to-humanities-and-social-sciences-evidence-from-china
#1
Meijun Liu, Dongbo Shi, Jiang Li
Humanities and Social Sciences (HSS) increasingly absorb knowledge from Hard Sciences, i.e., Science, Technology, Agriculture and Medicine (STAM), as testified by a growing number of citations. However, whether citing more Hard Sciences brings more citations to HSS remains to be investigated. Based on China's HSS articles indexed by the Web of Science during 1998-2014, this paper estimated two-way fixed effects negative binomial models, with journal effects and year effects. Findings include: (1) An inverse U-shaped curve was observed between the percentage of STAM references to the HSS articles and the number of citations they received; (2) STAM contributed increasing knowledge to China's HSS, while Science and Technology knowledge contributed more citations to HSS articles...
2017: PloS One
https://www.readbyqxmd.com/read/28920585/role-of-programmed-cell-death-4-in-diseases-a-double-edged-sword
#2
Yang Jiang, Yufeng Jia, Lining Zhang
No abstract text is available yet for this article.
September 18, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28915182/hyperoxia-in-septic-shock-crafty-therapeutic-weapon-or-double-edged-sword
#3
Pierre Asfar, Frédérique Schortgen, Markus Huber-Lang, Peter Radermacher
No abstract text is available yet for this article.
October 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28902346/prediction-of-radiosensitive-patients-with-gastric-cancer-by-developing-gene-signature
#4
Jin Zhou, Xiaoyu Wu, Gang Li, Xin Gao, Min Zhai, Weichang Chen, Huagang Hu, Zaixiang Tang
Adjuvant radiotherapy is an important clinical treatment for the majority of gastric cancer, a common cancer. However, radiotherapy is a double-edged sword. It is necessary to develop a method to predict radiosensitive patients who are most likely to benefit from radiotherapy. Using the publicly available data of gastric cancer from The Cancer Genome Atlas (TCGA), we developed a gene signature that predicts radiosensitive patients through estimating a new index, nominal HR (nHR) (HR product of sensitive genes), for each patient...
October 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28894119/evidence-for-biochemical-barrier-restoration-topical-solenopsin-analogs-improve-inflammation-and-acanthosis-in-the-kc-tie2-mouse-model-of-psoriasis
#5
Jack L Arbiser, Ron Nowak, Kellie Michaels, Yuliya Skabytska, Tilo Biedermann, Monica J Lewis, Michael Y Bonner, Shikha Rao, Linda C Gilbert, Nabiha Yusuf, Isabella Karlsson, Yi Fritz, Nicole L Ward
Psoriasis is a chronic inflammatory skin disease affecting 2.5-6 million patients in the United States. The cause of psoriasis remains unknown. Previous human and animal studies suggest that patients with a susceptible genetic background and some stimulus, such as barrier disruption, leads to a coordinated signaling events involving cytokines between keratinocytes, endothelial cells, T cells, macrophages and dendritic cells. Ceramides are endogenous skin lipids essential for maintaining skin barrier function and loss of ceramides may underlie inflammatory and premalignant skin...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891362/alternatives-to-antibiotics-in-poultry-feed-molecular-perspectives
#6
Gayatri Suresh, Ratul Kumar Das, Satinder Kaur Brar, Tarek Rouissi, Antonio Avalos Ramirez, Younes Chorfi, Stephane Godbout
The discovery of the growth promoting property of antibiotics led to their use as antibiotic feed additives (AFAs) in animal feed at sub-therapeutic doses. Although this has been beneficial for animal health and productivity, it has been, essentially, a double-edged sword. The continued and non-judicious use of AFAs has led to the selection and dissemination of antibiotic-resistant strains of poultry pathogens such as Salmonella, Campylobacter and Escherichia coli. The rapid spread of drug-resistant pathogens as well as emergence of antibiotic-related environmental pollutants is of global concern...
September 11, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28886737/students-as-anatomy-near-peer-teachers-a-double-edged-sword-for-an-ancient-skill
#7
Nomy Dickman, Alon Barash, Shmuel Reis, David Karasik
BACKGROUND: A near-peer instructors (NPI) program was designed for 1st year medical students who successfully finished the Anatomy course, in order to develop their didactic ability and teaching skills, mostly for cadaver dissection. METHODS: Graduates of the training program were administered a voluntary survey at the end of the program, annually. Best graduates of the training program were offered a NPI position in the next academic year. They were evaluated by the first-year students, at the end of the Anatomy block...
September 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28884426/thyroid-autoimmune-antibodies-in-patients-with-papillary-thyroid-carcinoma-a-double-edged-sword
#8
Chen-Tian Shen, Xin-Yun Zhang, Zhong-Ling Qiu, Zhen-Kui Sun, Wei-Jun Wei, Hong-Jun Song, Quan-Yong Luo
PURPOSE: The relationship between thyroid autoimmunity and thyroid cancer remains controversial. The objective of this study is to comprehensively analyze the association between thyroid autoimmune antibodies and disease statuses of papillary thyroid carcinoma (PTC). METHODS: Patients were divided into different groups according to their final diagnoses after radioiodine therapy as well as their serum anti-thyroglobulin antibody (TgAb) and anti-thyroidperoxidase antibody (TPOAb) titers...
September 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28838312/docosahexaenoic-acid-containing-choline-phospholipid-modulates-lps-induced-neuroinflammation-in-vivo-and-in-microglia-in-vitro
#9
Célia Fourrier, Julie Remus-Borel, Andrew D Greenhalgh, Michel Guichardant, Nathalie Bernoud-Hubac, Michel Lagarde, Corinne Joffre, Sophie Layé
BACKGROUND: Neuroinflammatory processes are considered a double-edged sword, having both protective and detrimental effects in the brain. Microglia, the brain's resident innate immune cells, are a key component of neuroinflammatory response. There is a growing interest in developing drugs to target microglia and control neuroinflammatory processes. In this regard, docosahexaenoic acid (DHA), the brain's n-3 polyunsaturated fatty acid, is a promising molecule to regulate pro-inflammatory microglia and cytokine production...
August 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28828367/spontaneous-breathing-a-double-edged-sword-to-handle-with-care
#10
REVIEW
Tommaso Mauri, Barbara Cambiaghi, Elena Spinelli, Thomas Langer, Giacomo Grasselli
In acute hypoxemic respiratory failure (AHRF) and acute respiratory distress syndrome (ARDS) patients, spontaneous breathing is associated with multiple physiologic benefits: it prevents muscles atrophy, avoids paralysis, decreases sedation needs and is associated with improved hemodynamics. On the other hand, in the presence of uncontrolled inspiratory effort, severe lung injury and asynchronies, spontaneous ventilation might also worsen lung edema, induce diaphragm dysfunction and lead to muscles exhaustion and prolonged weaning...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28821690/immune-checkpoint-inhibitor-therapy-a-double-edged-sword
#11
EDITORIAL
Ho Jin Kim, Amelia Evoli
No abstract text is available yet for this article.
August 18, 2017: Neurology
https://www.readbyqxmd.com/read/28812800/legalizing-marijuana-in-canada-a-double-edged-sword-a-response-to-recent-commentaries
#12
Mohammad Hajizadeh
No abstract text is available yet for this article.
December 14, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812377/a-cross-sectional-study-of-coping-resources-and-mental-health-of-chinese-older-adults-in-the-united-states
#13
Man Guo, Nadia Sabbagh Steinberg, Xinqi Dong, Agnes Tiwari
OBJECTIVES: This study examined the potential influence of coping resources at individual (sense of mastery), family (spousal and family support, children's filial piety), and community levels (community cohesion) on the mental health (depression, anxiety) of U.S. Chinese older adults. METHODS: The data were derived from the Population Study of Chinese Elderly in Chicago (N= 3,159). Negative binomial regressions were performed to predict depression and anxiety, respectively, by entering the three sets of coping resources separately and jointly, controlling for socio-demographic and acculturation variables...
August 16, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28770011/interactions-between-antidiabetic-drugs-and-herbs-an-overview-of-mechanisms-of-action-and-clinical-implications
#14
REVIEW
Ramesh C Gupta, Dennis Chang, Srinivas Nammi, Alan Bensoussan, Kellie Bilinski, Basil D Roufogalis
Diabetes is a complex condition with a variety of causes and pathophysiologies. The current single target approach has not provided ideal clinical outcomes for the treatment of the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with antidiabetic properties in addition to their mainstream treatments, which may present both a benefit as well as potential risk to effective management of their disease...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28769934/human-leukocyte-antigen-hla-and-immune-regulation-how-do-classical-and-non-classical-hla-alleles-modulate-immune-response-to-human-immunodeficiency-virus-and-hepatitis-c-virus-infections
#15
REVIEW
Nicole B Crux, Shokrollah Elahi
The genetic factors associated with susceptibility or resistance to viral infections are likely to involve a sophisticated array of immune response. These genetic elements may modulate other biological factors that account for significant influence on the gene expression and/or protein function in the host. Among them, the role of the major histocompatibility complex in viral pathogenesis in particular human immunodeficiency virus (HIV) and hepatitis C virus (HCV), is very well documented. We, recently, added a novel insight into the field by identifying the molecular mechanism associated with the protective role of human leukocyte antigen (HLA)-B27/B57 CD8(+) T cells in the context of HIV-1 infection and why these alleles act as a double-edged sword protecting against viral infections but predisposing the host to autoimmune diseases...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28765523/robust-spin-correlations-at-high-magnetic-fields-in-the-harmonic-honeycomb-iridates
#16
K A Modic, B J Ramshaw, J B Betts, Nicholas P Breznay, James G Analytis, Ross D McDonald, Arkady Shekhter
The complex antiferromagnetic orders observed in the honeycomb iridates are a double-edged sword in the search for a quantum spin-liquid: both attesting that the magnetic interactions provide many of the necessary ingredients, while simultaneously impeding access. Focus has naturally been drawn to the unusual magnetic orders that hint at the underlying spin correlations. However, the study of any particular broken symmetry state generally provides little clue about the possibility of other nearby ground states...
August 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28759312/wanted-and-unwanted-care-the-double-edged-sword-of-partial-do-not-resuscitate-orders
#17
Nobuhiro Ariyoshi, Masayuki Nogi, Damon Sakai, Eiji Hiraoka, Daniel Fischberg
BACKGROUND: The interpretation of do-not-resuscitate orders (DNRs) may vary in nonarrest situations. To reduce ambiguity, many hospitals allow patients to elect partial DNRs. OBJECTIVE: To investigate the effect of partial DNRs on physicians' willingness to perform cardiopulmonary resuscitation (CPR) and nonarrest procedures. DESIGN: Cross-sectional study using scenario-based questionnaires between October 2015 and March 2016. A partial DNR was identified as a DNR with Adult Emergency Protocols (AEP) order...
July 31, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28756624/double-edged-sword-of-mesenchymal-stem-cells-cancer-promoting-vs-therapeutic-potentials
#18
REVIEW
Hwa-Yong Lee, In-Sun Hong
Mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, cord blood, and other tissues, have recently attracted much attention as potential therapeutic agents in various diseases due to their trans-differentiation capacity. However, recent studies suggested that MSCs also appear to contribute tumor pathogenesis by supporting tumor microenvironments, increasing tumor growth, and eliciting anti-tumor immune responses. While some studies suggest that MSCs have the inhibitory effects on tumor development, they are overwhelmed by a member of researches that MSCs exert stimulatory effects on tumor pathogenesis...
July 30, 2017: Cancer Science
https://www.readbyqxmd.com/read/28753959/new-insights-into-the-role-of-autophagy-in-tumor-immune-microenvironment
#19
REVIEW
Chia-Jung Li, Wan-Ting Liao, Meng-Yu Wu, Pei-Yi Chu
The tumor microenvironment is a complex system that is affected by various factors, including hypoxia, acidosis, and immune and inflammatory responses, which have significant effects on tumor adhesion, invasion, metastasis, angiogenesis, and autophagy. In this hostile tumor microenvironment, autophagy of tumor cells can promote tumor growth and metastasis. As autophagy is a double-edged sword in tumors, treatment of cancer via regulation of autophagy is extremely complicated. Therefore, understanding the relationship between tumor autophagy and the tumor microenvironment is extremely important...
July 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28751953/pcsk9-and-carbohydrate-metabolism-a-double-edged-sword
#20
EDITORIAL
Theodosios D Filippatos, Sebastian Filippas-Ntekouan, Eleni Pappa, Thalia Panagiotopoulou, Vasilios Tsimihodimos, Moses S Elisaf
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a paramount role in the degradation of low-density lipoprotein (LDL) receptors (LDLR) on the hepatic cells surface and subsequently affects LDL particles catabolism and LDL cholesterol (LDL-c) levels. The anti-PCSK9 monoclonal antibodies lead to substantial decrease of LDL-c concentration. PCSK9 (which is also expressed in pancreatic delta-cells) can decrease LDLR and subsequently decrease cholesterol accumulation in pancreatic beta-cells, which impairs glucose metabolism and reduces insulin secretion...
July 15, 2017: World Journal of Diabetes
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