Zhishan Chen, Weiqiang Lin, Qiuyin Cai, Sun-Seog Kweon, Xiao-Ou Shu, Chizu Tanikawa, Wei-Hua Jia, Ying Wang, Xinwan Su, Yuan Yuan, Wanqing Wen, Jeongseon Kim, Aesun Shin, Sun Ha Jee, Keitaro Matsuo, Dong-Hyun Kim, Nan Wang, Jie Ping, Min-Ho Shin, Zefang Ren, Jae Hwan Oh, Isao Oze, Yoon-Ok Ahn, Keum Ji Jung, Yu-Tang Gao, Zhi-Zhong Pan, Yoichiro Kamatani, Weidong Han, Jirong Long, Koichi Matsuda, Wei Zheng, Xingyi Guo
Transcriptome-wide association studies (TWAS) have identified many putative susceptibility genes for colorectal cancer (CRC) risk. However, susceptibility miRNAs, critical dysregulators of gene expression, remain unexplored. We genotyped DNA samples from 313 CRC East Asian patients and performed small RNA sequencing in their normal colon tissues distant from tumors to build genetic models for predicting miRNA expression. We applied these models and data from genome-wide association studies (GWAS) including 23 942 cases and 217 267 controls of East Asian ancestry to investigate associations of predicted miRNA expression with CRC risk...
October 30, 2023: Human Molecular Genetics