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https://www.readbyqxmd.com/read/29746983/microrna-375-modulates-the-nf-%C3%AE%C2%BAb-pathway-in-miiuy-croaker-by-targeting-dusp1-gene
#1
Yuena Sun, Qing Chu, Xueyan Zhao, Zhenzhen Zhou, Dekun Bi, Tianjun Xu
microRNAs (miRNAs) are highly conserved, small non-coding endogenous molecule, and can participate in a variety of biological processes in organisms such as development, growth and immune response. Dual-Specificity Phosphatases (DUSPs) are enzymes that can remove phosphate groups from phosphatases. Research found that DUSP1 is an important molecule in the process of MAPK regulation. However, as a significant regulatory factor, the study of DUSP1 was very few in fish. Consequently, in this study, the regulatory role of miRNAs on DUSP1 has been verified through dual-luciferase reporter assay and western blotting analysis...
May 7, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29743907/circulating-mirna-levels-differ-with-respect-to-carotid-plaque-characteristics-and-symptom-occurrence-in-patients-with-carotid-artery-stenosis-and-provide-information-on-future-cardiovascular-events
#2
Rafal Badacz, Tadeusz Przewłocki, Jacek Gacoń, Ewa Stępień, Francisco J Enguita, Izabela Karch, Krzysztof Żmudka, Anna Kabłak-Ziembicka
Introduction: Circulating microRNAs (miRNAs) levels are potentially important biomarkers and therapeutic targets of cerebral ischemic event (CIE) in patients with internal carotid artery stenosis (ICAS). Aim: This prospective study investigated associations between circulating miRNAs and symptomatic and asymptomatic ICAS, carotid plaque morphology and future cardiovascular events. Material and methods: Circulating miRNAs (miR-1-3p, miR-16-5p, miR-34a-5p, miR-124-3p, miR-133a-3p, miR-133b, miR-134-5p, miR-208b-3p, miR-375 and miR-499-5p) were analyzed in 92 consecutive patients with significant ICAS referred for revascularization...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29722068/differential-ability-of-formononetin-to-stimulate-proliferation-of-endothelial-cells-and-breast-cancer-cells-via-a-feedback-loop-involving-microrna-375-rasd1-and-er%C3%AE
#3
Jian Chen, Xing Zhang, Yong Wang, Yu Ye, Zhaoquan Huang
For postmenopausal cardiovascular disease, long-term estrogen therapy may increase the risk of breast cancer. To reduce this risk, estrogen may be replaced with the phytoestrogen formononetin, but how formononetin acts on vascular endothelial cells (ECs) and breast cancer cells is unclear. Here, we show that low concentrations of formononetin induced proliferation and inhibited apoptosis more strongly in cultured human umbilical vein endothelial cells (HUVECs) than in breast cancer cells expressing estrogen receptor α (ERα) (MCF-7, BT474) or not (MDA-MB-231), and that this differential stimulation was associated with miR-375 up-regulation in HUVECs...
May 2, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29693141/analysis-of-nfkb2%C3%A2-mediated-regulation-of-mechanisms-underlying-the-development-of-hodgkin-s-lymphoma
#4
Yunping Zhang, Laigen Tong, Sisi Chen, Wenzhong Wu, Li Wang
Nuclear factor‑κB (NF‑κB) is widely involved in various lymphoid malignancies. However, its exact functional role and potential regulatory mechanisms in Hodgkin's lymphoma (HL) remains unclear. The present study aimed to investigate the regulatory mechanism of NF‑κB in HL by analysis of a gene expression profile that was obtained from HL cells with or without NF‑κB subunit 2 (NFKB2) knockdown. The GSE64234 dataset containing 6 HL cell line specimens transfected with small interfering (si)RNA against NFKB2 and 6 control specimens transfected with non‑targeting siRNA sequences was downloaded from the Gene Expression Omnibus database...
April 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29683529/morphology-combined-with-ancillary-techniques-an-algorithm-approach-for-thyroid-nodules
#5
Esther Diana Rossi, Maurizio Martini, Sara Capodimonti, Tonia Cenci, Mirna Bilotta, Francesco Pierconti, Alfredo Pontecorvi, Celestino Pio Lombardi, Guido Fadda, Luigi Maria Larocca
OBJECTIVE: Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques (AT), including immunocytochemistry(ICC) and molecular testing (MT), contributes to a better definition of the risk of malignancy(ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (i.e. BRAFV 600E ), miRNA analysis is proposed for FNs...
April 23, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29677549/mir-375-prevents-nasal-mucosa-cells-from-apoptosis-and-ameliorates-allergic-rhinitis-via-inhibiting-jak2-stat3-pathway
#6
Tao Wang, Dong Chen, Peihua Wang, Zhou Xu, Ying Li
This study aims to explore the roles, and related mechanisms of miR-375 in nasal mucosa cells apoptosis and allergic rhinitis. Here, miR-375 was found to be decreased in the epithelia of nasal mucosa of allergic rhinitis mice and TNF-α-stimulated nasal mucosa cells, while JAK2 expression exhibited an opposite effect. Mechanistically, miR-375/JAK2 regulatory axis was identified in nasal mucosa cells via luciferase reporter, qRT-PCR, western blot and RNA immune co-precipitation (RIP) assays. Pre- or post-injection of miR-375 agomir following ovalbumin (OVA) treatment attenuated OVA-induced allergic rhinitis, characterized as the downregulation of IL-6 and TNF-α secretion, and upregulation of IL-10 secretion, these effects were attenuated by infection with JAK2 adenovirus through nasal cavity inhalation...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29670837/assessing-the-effect-of-high-performance-inulin-supplementation-via-klf5-mrna-expression-in-adults-with-type-2-diabetes-a-randomized-placebo-controlled-clinical-trail
#7
Abed Ghavami, Neda Roshanravan, Shahriar Alipour, Meisam Barati, Behzad Mansoori, Faezeh Ghalichi, Elyas Nattagh-Eshtivan, Alireza Ostadrahimi
Purpose: The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly. Currently, the complications of diabetes are the major health concern. The aim of this study was to investigate the effect of high performance (HP) inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes. Methods: In the present clinical trial conducted for a duration of 6 weeks, 46 volunteers diabetic patients referring to diabetes clinic in Tabriz, Iran, were randomly assigned into intervention (n= 23, consuming 10 gr/d HP inulin) and control groups (n= 23, consuming 10 gr/ d starch)...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29603687/mir-7-mir-9-and-mir-375-contribute-to-effect-of-exendin-4-on-pancreatic-%C3%AE-cells-in-high-fat-diet-fed-mice
#8
Chang Guo, Yi-Qiong Sun, Qiang Li, Jin-Chao Zhang
PURPOSE: The purpose of this study was to test whether glucagon-like peptide-1 (GLP-1) receptor activation preserved pancreatic β-cells via the regulation of microRNAs and target genes in high-fat-diet-fed mice. METHODS: C57BL/6 male mice were simultaneously treated with high-fat-diet (HFD) and GLP-1 analogue, Exendin-4 (Ex-4) (3 μg/kg/day or 30 μg/kg/day), i.p. or vehicle, for consecutive 13 weeks. Fasting blood glucose, postprandial blood glucose, ΔI30/ΔG30, HOMA-IR and HOMA-% β were measured in each group...
March 27, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29587293/effects-of-mir-375-bmpr2-as-a-key-factor-downstream-of-bmp15-gdf9-on-the-smad1-5-8-and-smad2-3-signaling-pathways
#9
Chang Liu, Bao Yuan, Hongyan Chen, Mingqiang Xu, Xulei Sun, JiaJun Xu, Yan Gao, Chengzhen Chen, Hao Jiang, Jiabao Zhang
BACKGROUND/AIMS: Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), which are secreted by oocytes, are important regulators of follicular growth and development and ovarian function. These two factors can regulate the proliferation and apoptosis of cumulus cells via modulation of the Smad signaling pathway. Studies have shown that BMP15 and GDF9 can affect the level of miR-375, whereas the target gene of miR-375 is BMPR2, the type II receptor of BMP15 and GDF9...
March 21, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29569260/down-regulation-of-microrna-375-regulates-adipokines-and-inhibits-inflammatory-cytokines-by-targeting-adipor2-in-non-alcoholic-fatty-liver-disease
#10
Lei Lei, Chao Zhou, Xue Yang, Liangping Li
Non-alcoholic fatty liver disease (NAFLD) has been considered as a multi-factorial metabolic syndrome (MetS). MicroRNA-375 (MiR-375) was significantly up-regulated in serum of NAFLD patients and the role of miR-375 was addressed as a putative biomarker of NAFLD progression. However, the specific function of miR-375 in the progression of NAFLD is still unclear and the molecular mechanisms underlying NAFLD have yet to be elucidated. Our study aimed at investigating the regulatory role of miR-375 in the molecular mechanisms of the pathogenic progression of NAFLD and to find out whether miR-375 regulates the expression level of adipokines and inflammatory cytokines in NAFLD...
March 22, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29555460/enhancing-anti-tumor-efficiency-in-hepatocellular-carcinoma-through-the-autophagy-inhibition-by-mir-375-sorafenib-in-lipid-coated-calcium-carbonate-nanoparticles
#11
Pengxuan Zhao, Minsi Li, Yao Wang, Yan Chen, Chuanchuan He, Xiaojuan Zhang, Tan Yang, Yao Lu, Jia You, Robert J Lee, Guangya Xiang
Sorafenib is a first-line drug for hepatocellular carcinoma (HCC). Autophagy has been shown to facilitate sorafenib resistance. miR-375 has been shown to be an inhibitor of autophagy. In this study, miR-375 and sorafenib were co-loaded into calcium carbonate nanoparticles with lipid coating (miR-375/Sf-LCC NPs). The nanoparticles had high loading efficiency and were ∼50 nm in diameter. Besides, the NPs could increase the stability and residence time of both drugs. Moreover, we demonstrated that autophagy was activated in HCC cells by sorafenib but not by miR-375/Sf-LCC NPs...
May 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29529473/in-vivo-short-term-topical-application-of-bay-11-7082-prevents-the-acidic-bile-induced-mrna-and-mirna-oncogenic-phenotypes-in-exposed-murine-hypopharyngeal-mucosa
#12
Clarence T Sasaki, Sotirios G Doukas, Dimitra P Vageli
PURPOSE: Bile-containing gastroesophageal reflux may promote cancer at extraesophageal sites. Acidic bile can accelerate NF-κB activation and molecular events, linked to premalignant changes in murine hypopharyngeal mucosa (HM). We hypothesize that short-term in vivo topical application of NF-κB inhibitor BAY 11-7082 can prevent acidic bile-induced early preneoplastic molecular events, suggesting its potential role in disease prevention. EXPERIMENTAL DESIGN: We topically exposed HM (C57Bl/6j wild-type) to a mixture of bile acids at pH 3...
April 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29522716/combined-inhibition-of-egfr-and-c-abl-suppresses-the-growth-of-fulvestrant-resistant-breast-cancer-cells-through-mir-375-autophagy-axis
#13
Lunming Liu, Weifeng Shen, Zhihui Zhu, Jinxiong Lin, Qingxia Fang, Yeping Ruan, Huajun Zhao
Fulvestrant is the FDA-approved "pure anti-estrogen" agent for malignant breast cancer therapy. But endocrine resistance causes drug failure. A new approach is desired for fulvestrant-resistant breast cancer (FRBC) therapy. This study aims to find an effective approach to inhibit FRBC for patients with advanced breast cancer. MTT assay was first performed to detect the effect of inhibitors of c-ABL (imatinib) and EGFR (lapatinib) on FRBC cells. Microarray analysis was carried out to identify microRNA which is significantly changed between parental and FRBC cells...
April 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29516639/nf-%C3%AE%C2%BAb-inhibition-reverses-acidic-bile-induced-mir-21-mir-155-mir-192-mir-34a-mir-375-and-mir-451a-deregulations-in-human-hypopharyngeal-cells
#14
Sotirios G Doukas, Dimitra P Vageli, Clarence T Sasaki
We previously demonstrated that acidic bile activates NF-κB, deregulating the expression of oncogenic miRNA markers, in pre-malignant murine laryngopharyngeal mucosa. Here, we hypothesize that the in vitro exposure of human hypopharyngeal cells to acidic bile deregulates cancer-related miRNA markers that can be reversed by BAY 11-7082, a pharmacologic NF-κB inhibitor. We repetitively exposed normal human hypopharyngeal primary cells and human hypopharyngeal keratinocytes to bile fluid (400 μmol/L), at pH 4...
May 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29514449/mir-375-down-regulation-of-the-rlf-and-higd1a-genes-and-effects-on-st-cell-proliferation
#15
Jia Guo, Xin Liu, Yuwei Yang, Mengdi Liang, Chunyan Bai, Zhihui Zhao, Boxing Sun
Objective: This study aimed to screen and identify the target genes of miR-375 in pig Sertoli (ST) cells and to elucidate the effect of miR-375 on the proliferation of ST cells. Methods: In this study, bioinformatics software was used to predict and verify miR-375 target genes. Quantitative PCR was used to detect the relationship between miR-375 and its target genes in ST cells. ELISA of RLF and HIGD1A was performed on porcine ST cells, which were transfected with a miR-375 mimics and inhibitor to verify the results...
March 2, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29487354/mirna-profiling-of-small-intestinal-neuroendocrine-tumors-defines-novel-molecular-subtypes-and-identifies-mir-375-as-a-biomarker-of-patient-survival
#16
Yvonne Arvidsson, Anna Rehammar, Anders Bergström, Ellinor Andersson, Gülay Altiparmak, Christina Swärd, Bo Wängberg, Erik Kristiansson, Ola Nilsson
The aim of this study was to define the miRNA profile of small intestinal neuroendocrine tumors and to search for novel molecular subgroups and prognostic biomarkers. miRNA profiling was conducted on 42 tumors from 37 patients who underwent surgery for small intestinal neuroendocrine tumors. Unsupervised hierarchical clustering analysis of miRNA profiles identified two groups of tumor metastases, denoted cluster M1 and M2. The smaller cluster M1 was associated with shorter overall survival and contained tumors with higher grade (WHO grade G2/3) and multiple chromosomal gains including gain of chromosome 14...
February 27, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29482431/microrna-meta-signature-of-oral-cancer-evidence-from-a-meta-analysis
#17
Katarina Zeljic, Ivan Jovanovic, Jasmina Jovanovic, Zvonko Magic, Aleksandra Stankovic, Gordana Supic
AIM: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. MATERIAL AND METHODS: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. RESULTS: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue...
March 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29445851/beta-cell-extracellular-vesicle-mir-21-5p-cargo-is-increased-in-response-to-inflammatory-cytokines-and-serves-as-a-biomarker-of-type-1-diabetes
#18
Alexander J Lakhter, Rachel E Pratt, Rachel E Moore, Kaitlin K Doucette, Bernhard F Maier, Linda A DiMeglio, Emily K Sims
AIMS/HYPOTHESIS: Improved biomarkers are acutely needed for the detection of developing type 1 diabetes, prior to critical loss of beta cell mass. We previously demonstrated that elevated beta cell microRNA 21-5p (miR-21-5p) in rodent and human models of type 1 diabetes increased beta cell apoptosis. We hypothesised that the inflammatory milieu of developing diabetes may also increase miR-21-5p in beta cell extracellular vesicle (EV) cargo and that circulating EV miR-21-5p would be increased during type 1 diabetes development...
May 2018: Diabetologia
https://www.readbyqxmd.com/read/29439669/a-novel-mir-375-hoxb3-cdca3-dnmt3b-regulatory-circuitry-contributes-to-leukemogenesis-in-acute-myeloid-leukemia
#19
Laixi Bi, Bin Zhou, Haiying Li, Licai He, Chunjing Wang, Zhonggai Wang, Liqing Zhu, Mengqian Chen, Shenmeng Gao
BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies due to sophisticated genetic mutations and epigenetic dysregulation. MicroRNAs (miRNAs), a class of small non-coding RNAs, are important regulators of gene expression in all biological processes, including leukemogenesis. Recently, miR-375 has been reported to be a suppressive miRNA in multiple types of cancers, but its underlying anti-leukemia activity in AML is largely unknown. METHODS: Quantitative reverse transcriptase PCR (qRT-PCR) was used to measure the expression of miR-375 and HOXB3 in leukemic cells and normal controls...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29436665/microrna-375-inhibits-glioma-cell-proliferation-and-migration-by-downregulating-rwdd3-in-vitro
#20
Chen-Xing Ji, Yang-Hua Fan, Fan Xu, Shi-Gang Lv, Min-Hua Ye, Miao-Jing Wu, Xin-Gen Zhu, Lei Wu
Derived from brain glial cells, gliomas are currently the most common primary tumours in the central nervous system and are characterised by a high recurrence rate and poor prognosis. RWDD3 (RWD domain-containing sumoylation enhancer, also termed RSUME), which can be induced by cellular stress, such as CoCl2, heat shock and hypoxia, may play a crucial role in tumour angiogenesis, growth and metastasis. MicroRNAs (miRNAs) have been demonstrated to act as negative regulators of post-transcriptional gene expression and are involved in tumour growth and metastasis...
April 2018: Oncology Reports
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