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https://www.readbyqxmd.com/read/28075453/mir-375-inhibits-cancer-stem-cell-phenotype-and-tamoxifen-resistance-by-degrading-hoxb3-in-human-er-positive-breast-cancer
#1
Hui Fu, Lei Fu, Chao Xie, Wen-Shu Zuo, Yan-Song Liu, Mei-Zhu Zheng, Jin-Ming Yu
Cancer stem cell (CSC) formation and epithelial-mesenchymal transition (EMT) are pivotal events in tumor cell invasion and metastasis. They have been shown to occur in resistance to tamoxifen. Moreover, microRNAs (miRNAs) have been associated with CSCs, EMT as well as tamoxifen resistance. Studying molecular mechanism of CSCs, EMT as well as tamoxifen resistance will help us to further understand the pathogenesis and progression of the disease and offer new targets for effective therapies. In the present study, we showed that miR-375 inhibits CSC traits in breast cancer MCF-7 cells...
January 9, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28069583/mir-375-suppresses-invasion-and-metastasis-by-direct-targeting-of-shox2-in-esophageal-squamous-cell-carcinoma
#2
Jun Yi, Li Jin, Jing Chen, Bing Feng, Zhenyue He, Longbang Chen, Haizhu Song
Esophageal squamous cell carcinoma (ESCC) is the most common histological type in China. MicroRNAs are endogenously expressed in mammals and play a significant role in tumor invasion and metastasis by targeting potential downstream genes. In the present study, microarray analysis showed that miR-375 expression was distinctly downregulated in ESCC compared with that in normal esophageal epithelium tissues. Then, luciferase reporter assay showed that SHOX2 was the direct downstream target of miR-375 and this interaction was confirmed by the rescue experiments...
January 8, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28053808/dysregulation-of-microrna-196b-5p-and-microrna-375-in-gastric-cancer
#3
Seung Woo Lee, Ki Cheol Park, Jeong Goo Kim, Sung Jin Moon, Sang Bum Kang, Dong Soo Lee, Hae Joung Sul, Jeong Seon Ji, Hyun Yong Jeong
PURPOSE: Dysregulated microRNAs (miRNAs) can contribute to cancer development by leading to abnormal proliferation of cells, apoptosis, and differentiation. Although several miRNAs that are related to gastric cancer have been identified, the reported results have been inconsistent. The aim of this study was to determine miRNA expression profiles and validate miRNAs up- and down-regulated in gastric cancer. MATERIALS AND METHODS: We evaluated 34 primary gastric cancer tissues and paired adjacent nontumorous gastric tissues...
December 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28053090/functional-transcriptomics-in-diverse-intestinal-epithelial-cell-types-reveals-robust-microrna-sensitivity-in-intestinal-stem-cells-to-microbial-status
#4
Bailey C E Peck, Amanda T Mah, Wendy A Pitman, Shengli Ding, P Kay Lund, Praveen Sethupathy
Gut microbiota play an important role in regulating the development of the host immune system, metabolic rate, and at times, disease pathogenesis. The factors and mechanisms that mediate interactions between microbiota and the intestinal epithelium are not fully understood. We provide novel evidence that microbiota may control intestinal epithelial stem cell (IESC) proliferation in part through microRNAs (miRNAs). We demonstrate that miRNA profiles differ dramatically across functionally distinct cell types of the mouse jejunal intestinal epithelium and that miRNAs respond to microbiota in a highly cell-type specific manner...
January 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28039581/microrna-expression-profiles-of-human-ipscs-differentiation-into-insulin-producing-cells
#5
Guido Sebastiani, Marco Valentini, Giuseppina Emanuela Grieco, Giuliana Ventriglia, Laura Nigi, Francesca Mancarella, Silvia Pellegrini, Gianvito Martino, Valeria Sordi, Lorenzo Piemonti, Francesco Dotta
AIMS: MicroRNAs are a class of small noncoding RNAs, which control gene expression by inhibition of mRNA translation. MicroRNAs are involved in the control of biological processes including cell differentiation. Here, we aim at characterizing microRNA expression profiles during differentiation of human induced pluripotent stem cells (hiPSCs) into insulin-producing cells. METHODS: We differentiated hiPSCs toward endocrine pancreatic lineage following a 18-day protocol...
December 30, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/28030794/circulating-mirnas-as-biomarkers-for-oral-squamous-cell-carcinoma-recurrence-in-operated-patients
#6
Yan Yan, Xuan Wang, Morten T Venø, Vivi Bakholdt, Jens A Sørensen, Annelise Krogdahl, Zheng Sun, Shan Gao, Jørgen Kjems
MicroRNAs (miRNAs) are small regulatory non-coding RNAs for which altered expression in cancers can serve as potential biomarkers for diseases. We here investigated whether circulating miRNAs can serve as biomarkers for predicting post-operational recurrence of oral squamous cell carcinoma (OSCC) in patients. Plasma samples from 8 Danish OSCC patients were collected before, and one year after surgical operation, as well as from 3 Danish healthy controls and subjected to miRNA profiling by next generation sequencing...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28017506/insulin-producing-cells-generation-by-overexpression-of-mir-375-in-adipose-derived-mesenchymal-stem-cells-from-diabetic-patients
#7
Mehran Piran, Seyed Ehsan Enderami, Mehrdad Piran, Hadis Soltani Sedeh, Ehsan Seyedjafari, Abdolreza Ardeshirylajimi
Diabetes Mellitus (DM) is a systematic disease, which happens because of destruction of islets of Langerhans in the pancreas and systematic resistance to insulin. The lack of donor for pancreas transplantation and risk of transplant rejection is the main challenge in the treatment of this disease. Stem cells are proper and sufficient source for creating insulin-producing cells (IPC). In this study adipose tissue was provided from diabetic patients operated for liposuction and then adipose derived stem cells (ADSCs) were isolated, characterized and then treated by lentiviruses containing miR-375, after 7, 14 and 21 days of induction, islet-like clusters (ILC) specific genes including insulin and PDX1 were evaluated by Real Time RT-PCR...
December 22, 2016: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28006751/mir-375-ameliorates-sepsis-by-downregulating-mir-21-level-via-inhibiting-jak2-stat3-signaling
#8
Bo Sheng, Lei Zhao, Xuefeng Zang, Jie Zhen, Wei Chen
Accumulating evidences have confirmed that miRNAs have important roles in sepsis. Myeloid-derived suppressor cells (MDSCs) enhance late sepsis development through immunosuppression in mice. Here, the functions and mechanisms of miR-375 in sepsis were revealed. We found that miR-375 level was downregulated but miR-21 level was upregulated in sepsis patients and that their levels were correlated negatively. Importantly, ectopic expression of miR-375 could decrease the number of sepsis Gr1+CD11b+ MDSCs in mice...
December 19, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28000902/microrna%C3%A2-375-inhibits-oral-squamous-cell-carcinoma-cell-migration-and-invasion-by-targeting-platelet%C3%A2-derived-growth-factor%C3%A2-a
#9
Zheng-Hao Cao, Jing-Liang Cheng, Yong Zhang, Chun-Xiao Bo, Yan-Liang Li
MicroRNA‑375 (miR‑375) serves an important role in cancer development and growth. However, little is known about the role of miR‑375 in the regulation of oral squamous cell carcinoma (OSCC) metastasis and invasion. The present study measured the expression levels of miR‑375 in Tca8113, UM2, UM1 and CAL‑27 cell lines, using reverse transcription‑quantitative polymerase chain reaction. The results demonstrated that miR‑375 expression levels were significantly reduced in UM1 and CAL‑27 (highly metastatic) compared with Tca8113 and UM2 (less aggressive) OSCC cell lines...
December 19, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27998789/dna-methylation-contributes-to-deregulation-of-12-cancer-associated-micrornas-and-breast-cancer-progression
#10
Irina V Pronina, Vitaly I Loginov, Alexey M Burdennyy, Marina V Fridman, Vera N Senchenko, Tatiana P Kazubskaya, Nikolay E Kushlinskii, Alexey A Dmitriev, Eleonora A Braga
The methylation of promoter CpG islands and the interaction between microRNAs (miRNAs) and messenger RNAs (mRNAs) of target genes are considered two crucial mechanisms for gene and pathway deregulation in malignant tumors. The aim of this study was to analyze the role of promoter methylation in altering the expression of 13 miRNAs that are associated with breast cancer (BC): miR-124, -125b, -127, -132, -137, -148a, -191, -193a, -203, -212, -34b, -375, -9. The role of methylation in the deregulation of these miRNAs has not been previously assessed in the representative set of BC samples...
March 10, 2017: Gene
https://www.readbyqxmd.com/read/27990656/exosomal-and-non-exosomal-urinary-mirnas-in-prostate-cancer-detection-and-prognosis
#11
Laura Foj, Ferran Ferrer, Marta Serra, Antonio Arévalo, Montserrat Gavagnach, Nuria Giménez, Xavier Filella
BACKGROUND: MicroRNAs (miRNAs) are non-coding small RNAs, involved in post-transcriptional regulation of many target genes. METHODS: Five miRNAs that have been consistently found deregulated in PCa (miR-21, miR-141, miR-214, miR-375, and let-7c) were analyzed in urinary pellets from 60 prostate cancer (PCa) patients and 10 healthy subjects by qRT-PCR. Besides, urinary exosomes were isolated by differential centrifugation and analyzed for those miRNAs. RESULTS: Significant upregulation of miR-21, miR-141, and miR-375 was found comparing PCa patients with healthy subjects in urinary pellets, while miR-214 was found significantly downregulated...
December 19, 2016: Prostate
https://www.readbyqxmd.com/read/27937745/ionizing-radiation-alters-human-embryonic-stem-cell-properties-and-differentiation-capacity-by-diminishing-the-expression-of-activin-receptors
#12
Sabine Luft, Onetsine Arrizabalaga, Ireen Kulish, Elena Nasonova, Marco Durante, Sylvia Ritter, Insa S Schroeder
Exposure of the embryo to ionizing radiation (IR) is detrimental as it can cause genotoxic stress leading to immediate and latent consequences such as functional defects, malformations, or cancer. Human embryonic stem (hES) cells can mimic the preimplantation embryo and help to assess the biological effects of IR during early development. In this study, we describe the alterations H9 hES cells exhibit after X-ray irradiation in respect to cell cycle progression, apoptosis, genomic stability, stem cell signaling, and their capacity to differentiate into definitive endoderm...
December 22, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27904783/circulating-mirna-profile-in-esophageal-adenocarcinoma
#13
Keqiang Zhang, Xiwei Wu, Jinhui Wang, Joshua Lopez, Weiying Zhou, Lu Yang, Shizhen Emily Wang, Dan J Raz, Jae Y Kim
Esophageal cancer is one of the deadliest cancers worldwide. It typically has a poor overall prognosis because of diagnosis in advanced stages. Sensitive biomarkers for the early detection of esophageal cancer are urgently needed to reduce the high mortality of this disease. Circulating microRNAs (miRNAs) are emerging as a novel non-invasive biomarker for cancer diagnosis due to its high stability and specificity. In this study, we profiled circulating miRNAs in serum of patients with esophageal adenocarcinoma (EAC) using the Solexa sequencing analysis...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27898025/identification-and-characterization-of-micrornas-in-the-liver-of-blunt-snout-bream-megalobrama-amblycephala-infected-by-aeromonas-hydrophila
#14
Lei Cui, Hongtao Hu, Wei Wei, Weimin Wang, Hong Liu
MicroRNAs (miRNAs) are small RNA molecules that play key roles in regulation of various biological processes. In order to better understand the biological significance of miRNAs in the context of Aeromonas hydrophila infection in Megalobrama amblycephala, small RNA libraries obtained from fish liver at 0 (non-infection), 4, and 24 h post infection (poi) were sequenced using Illumina deep sequencing technology. A total of 11,244,207, 9,212,958, and 7,939,157 clean reads were obtained from these three RNA libraries, respectively...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27885434/evaluation-of-mir-21-and-mir-375-as-prognostic-biomarkers-in-oesophageal-cancer-in-high-risk-areas-in-china
#15
Yutong He, Jing Jin, LiQun Wang, Yuejiao Hu, Di Liang, Huichai Yang, Yueping Liu, Baoen Shan
MicroRNAs have been associated with prognosis in oesophageal cancer (EC), suggesting that miRNAs could play a role in guiding treatment decisions. The aim of this study was to evaluate the prognostic potential of miRNAs found to be associated with zinc deficiency in a geographical area with a high incidence of EC. miRNAs found to be associated with zinc deficiency were isolated from EC cell lines cultured with various Zn levels. The expression levels of the miRNAs were quantified using qRT-PCR. The potential prognostic value of the selected miRNAs was assessed in a cohort study of 88 patients from an area in China with a high incidence of EC...
November 24, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27884727/impact-of-17beta-estradiol-and-progesterone-on-inflammatory-and-apoptotic-microrna-expression-after-ischemia-in-a-rat-model
#16
Rebecca Herzog, Adib Zendedel, Leoni Lammerding, Cordian Beyer, Alexander Slowik
17β-estradiol (E2) and progesterone (P) are neuroprotective factors in the brain preventing neuronal death under different injury paradigms. In previous studies, we demonstrated that both steroids dampen neuronal damage, improve local energy metabolism and attenuate pro-inflammatory responses. MicroRNAs (miRNAs) are small regulators of distinct target genes on the RNA level. Their expression patterns are misbalanced in several neurological disorders. To explore the regulatory mechanisms of steroid hormones on selected miRNAs and their validated targets in ischemia, we used the transient middle cerebral artery occlusion (tMCAO) model...
November 22, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27880727/gold-nanoparticles-delivered-mir-375-for-treatment-of-hepatocellular-carcinoma
#17
Hui-Ying Xue, Yong Liu, Jia-Zhi Liao, Ju-Sheng Lin, Bin Li, Wei-Gang Yuan, Robert J Lee, Lei Li, Chuan-Rui Xu, Xing-Xing He
MiR-375 is a tumor suppressor miRNA that is downregulated in hepatocellular carcinoma (HCC). However, due to the lack of effective delivery strategies, miR-375 replacement as a therapy for HCC has not been investigated. In the present study, we have developed a straightforward strategy to deliver miR-375 into HCC cells by assembling miR-375 mimics on the surface of AuNPs and forming AuNP-miR-375 nanoparticles. AuNP-miR-375 exhibits high cellular uptake and preserves miR-375's activities to suppress cellular proliferation, migration/invasion, and colony formation, and to induce apoptosis in HCC cells...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27878285/trichostatin-a-increases-radiosensitization-of-tongue-squamous-cell-carcinoma-via-mir%C3%A2-375
#18
Lingfei Jia, Shan Zhang, Yiping Huang, Yunfei Zheng, Yehua Gan
Trichostatin A (TSA), a histone deacetylase inhibitor, is used as an anti-carcinogenic and radiosensitizing agent in various cancers. However, the role and mechanism underlying its radiosensitization of tongue squamous cell carcinoma (TSCC) remains unclear. Thus, in this study we aimed to confirm the promotion of miR‑375 expression by TSA, and to investigate the effects of TSA and miR‑375 in the radiosensitivity of TSCC cells. The results showed that TSA had significant radiosensitizing effects on TSCC cells and miR‑375 overexpression had effects similar to TSA in sensitizing these cells to radiotherapy...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/27866884/microrna-biomarkers-of-pancreatic-injury-in-a-canine-model
#19
Rodney Rouse, Barry Rosenzweig, Katie Shea, Alan Knapton, Sharron Stewart, Lin Xu, Ashok Chockalingam, Leah Zadrozny, Karol Thompson
Pancreas-enriched microRNAs have been experimentally investigated in rodents as candidate serum biomarkers of pancreatic injury with several different acute pancreatic injury models. In the present study, temporal and magnitude responses of exocrine pancreas-enriched miR-216a, miR-216b, and miR-217 and endocrine-enriched miR-375 and miR-148a were measured by droplet digital PCR in serum in a caerulein model of pancreatic injury in the dog. All 5 microRNAs followed a similar time course that mirrored the responses of the conventional serum pancreatic injury biomarkers, amylase and lipase...
January 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27866223/circulating-microrna-levels-predict-residual-beta-cell-function-and-glycaemic-control-in-children-with-type-1-diabetes-mellitus
#20
Nasim Samandari, Aashiq H Mirza, Lotte B Nielsen, Simranjeet Kaur, Philip Hougaard, Siri Fredheim, Henrik B Mortensen, Flemming Pociot
AIMS/HYPOTHESIS: We aimed to identify circulating microRNA (miRNA) that predicts clinical progression in a cohort of 123 children with new-onset type 1 diabetes mellitus. METHODS: Plasma samples were prospectively obtained at 1, 3, 6, 12 and 60 months after diagnosis from a subset of 40 children from the Danish Remission Phase Cohort, and profiled for miRNAs. At the same time points, meal-stimulated C-peptide and HbA1c levels were measured and insulin-dose adjusted HbA1c (IDAA1c) calculated...
February 2017: Diabetologia
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