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Fenofibrate

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https://www.readbyqxmd.com/read/27889747/alisol-a-24-acetate-prevents-hepatic-steatosis-and-metabolic-disorders-in-hepg2-cells
#1
Lu Zeng, WaiJiao Tang, JinJin Yin, LiJuan Feng, Yabing Li, Xiaorui Yao, BenJie Zhou
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic disorders including hepatic lipid accumulation and inflammation. Alisol A 24-acetate, a triterpene from Alismatis rhizome, has multiple biologic activities such as hypolipidemic, anti-inflammatory and anti-diabetic. Thus we hypothesized that Alisol A 24 -acetate would have effect on NAFLD. The present study was conducted to investigate the therapeutic effects and potential mechanisms of Alisol A 24-acetate against hepatic steatosis in a free fatty acids (FFAs) induced NAFLD cell model...
November 25, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27888753/gastrointestinal-bleeding-and-intracranial-hemorrhage-in-concomitant-users-of-warfarin-and-antihyperlipidemics
#2
Charles E Leonard, Colleen M Brensinger, Warren B Bilker, Stephen E Kimmel, Xu Han, Young Hee Nam, Joshua J Gagne, Margaret J Mangaali, Sean Hennessy
BACKGROUND: Drug interactions, particularly those involving warfarin, are a major clinical and public health problem. Minimizing serious bleeding caused by anticoagulants is a recent major focus of the United States (US) Department of Health and Human Services. This study quantified the risk of gastrointestinal bleeding (GIB) and intracranial hemorrhage (ICH) among concomitant users of warfarin and individual antihyperlipidemics. METHODS: The authors conducted a high-dimensional propensity score-adjusted cohort study of new concomitant users of warfarin and an antihyperlipidemic, among US Medicaid beneficiaries from five states during 1999-2011...
November 12, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27884714/carrier-particle-design-for-stabilization-and-isolation-of-drug-nanoparticles
#3
Teresa Tierney, Katalin Bodnár, Åke Rasmuson, Sarah Hudson
Nanoparticles of poorly water-soluble drugs were prepared in suspension via antisolvent precipitation in order to improve their dissolution behaviour. Insoluble, surface-functionalized, micron-range, clay carrier particles were employed for the dual purpose of stabilizing the nanoparticles in suspended state, and facilitating their unhindered isolation to solid state; often a challenging step in nanoparticle production. The carrier particles, which were functionalized with an optimal level of cationic polymer (protamine), attracted negatively-charged nanoparticles to their surface as a uniform and segregated nanoparticle layer, at drug loadings up to 9% w/w...
November 21, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27868450/pharmacological-management-of-diabetic-dyslipidemia
#4
T D Filippatos, M Florentin, M Georgoula, M S Elisaf
Diabetes mellitus is associated with increased cardiovascular disease (CVD) risk. Areas covered: Main goal of hypolipidemic treatment in diabetic patients is low-density lipoprotein cholesterol (LDL-C) lowering with the use of statins. Addition of ezetimibe is useful in diabetic patients who cannot achieve their LDL-C target. However, many diabetic patients have increased residual CVD risk, which is mainly attributed to high triglycerides and low high-density lipoprotein (HDL-C) values. The addition of fenofibrate targets these variables and possibly reduces residual CVD risk, but a possible beneficial effect has been shown only in a pre-specified subgroup analysis in patients with high triglycerides and low HDL-C values...
December 2, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27865930/evaluation-of-different-in-vitro-dissolution-tests-based-on-level-a-in-vitro-in-vivo-correlations-for-fenofibrate-self-emulsifying-lipid-based-formulations
#5
Aude Pestieau, Sonia Lebrun, Bernard Cahay, Adeline Brouwers, Bruno Streel, Jean-Michel Cardot, Brigitte Evrard
No abstract text is available yet for this article.
November 16, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27861729/antidepressant-like-effects-of-fenofibrate-in-mice-via-the-hippocampal-bdnf-signaling-pathway
#6
Bo Jiang, Ying-Jie Wang, Hao Wang, Lu Song, Chao Huang, Qing Zhu, Feng Wu, Wei Zhang
BACKGROUND AND PURPOSE: Depression is a neuropsychiatric disorder accompanied by decreased brain derived neurotrophic factor (BDNF) signaling cascade in the hippocampus. Fenofibrate is a selective agonist of peroxisome proliferator-activated receptor-α (PPAR-α). In this study, we investigated the antidepressant-like effects of fenofibrate in C57BL/6 J mice. EXPERIMENTAL APPROACH: The antidepressant-like effects of fenofibrate were first detected in the forced swim test (FST) and tail suspension test (TST), and then assessed in the chronic social defeat stress (CSDS) model...
November 15, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27845265/the-effects-of-herbal-composition-gambigyeongsinhwan-4-on-hepatic-steatosis-and-inflammation-in-otsuka-long-evans-tokushima-fatty-rats-and-hepg2-cells
#7
Seolah Yoon, Jeongjun Kim, Hyunghee Lee, Haerim Lee, Jonghoon Lim, Heejeong Yang, Soon Shik Shin, Michung Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Hepatic steatosis has risen rapidly in parallel with a dramatic increase in obesity. The aim of this study was to determine whether the herbal composition Gambigyeongsinhwan (4) (GGH(4)), composed of Curcuma longa L. (Zingiberaceae), Alnus japonica (Thunb.) Steud. (Betulaceae), and the fermented traditional Korean medicine Massa Medicata Fermentata, regulates hepatic steatosis and inflammation. MATERIALS AND METHODS: The effects of GGH(4) on hepatic steatosis and inflammation in Otsuka Long-Evans Tokushima fatty (OLETF) rats and HepG2 cells were examined using Oil red O, hematoxylin and eosin, and toluidine blue staining, immunohistochemistry, quantitative real-time polymerase chain reaction, and peroxisome proliferator-activated receptor α (PPARα) transactivation assay...
November 11, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27822849/physicochemical-properties-of-solid-phospholipid-particles-as-a-drug-delivery-platform-for-improving-oral-absorption-of-poorly-soluble-drugs
#8
Kohsaku Kawakami, Aoi Miyazaki, Mayuko Fukushima, Keiko Sato, Yuko Yamamura, Kohta Mohri, Shinji Sakuma
PURPOSE: A novel drug delivery platform, mesoporous phospholipid particle (MPP), is introduced. Its physicochemical properties and ability as a carrier for enhancing oral absorption of poorly soluble drugs are discussed. METHODS: MPP was prepared through freeze-drying a cyclohexane/t-butyl alcohol solution of phosphatidylcholine. Its basic properties were revealed using scanning electron microscopy, x-ray diffraction, thermal analysis, hygroscopicity measurement, and so on...
November 7, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27819772/triglycerides-atherosclerosis-and-cardiovascular-outcome-studies-focus-on-omega-3-fatty-acids
#9
Yehuda Handelsman, Michael D Shapiro
Despite improved atherosclerotic cardiovascular disease (ASCVD) outcomes with statin therapy, residual risk remains. Recent genetic insights provide further compelling evidence that triglycerides are in the causal pathway for the development of atherosclerosis, thereby renewing interest in targeting triglycerides to improve ASCVD outcomes. Fibrates, niacin, and omega-3 fatty acids (OM3FAs) are 3 classes of triglyceride-lowering drugs. Outcome studies with triglyceride-lowering agents have been inconsistent...
November 7, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27807394/peroxisome-proliferator-activated-receptor-%C3%AE-reduces-endothelin-1-caused-cardiomyocyte-hypertrophy-by-inhibiting-nuclear-factor-%C3%AE%C2%BAb-and-adiponectin
#10
Hsu-Lung Jen, Po-Len Liu, Yung-Hsiang Chen, Wei-Hsian Yin, Jaw-Wen Chen, Shing-Jong Lin
Peroxisome proliferator-activated receptor α (PPARα) plays a role in the pathogenesis of cardiac hypertrophy, although its underlying mechanism remains unclear. The purpose of this study was to evaluate the effect of PPARα activation on endothelin-1- (ET-1-) caused cardiomyocyte hypertrophy and explore its underlying mechanisms. Human cardiomyocytes (HCMs) were cultured with or without ET-1, whereafter the inhibitory effects of fenofibrate, a PPARα activator, on cell size and adiponectin protein were tested...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27803862/clinical-research-of-fenofibrate-and-spironolactone-for-acute-central-serous-chorioretinopathy
#11
Yong Chai, Rong-Qiang Liu, Jing-Lin Yi, Ling-Hong Ye, Jing Zou, Nan Jiang, Yi Shao
AIM: To compare the effectiveness of combined fenofibrate and spironolactone with fenofibrate alone for treatment of central serous chorioretinopathy (CSCR). METHODS: Totally 60 patients (60 eyes) with a history of acute CSCR were randomed into two groups: group A with combination of fenofibrate (200 mg) and spironolactone (100 mg), and group B with only fenofibrate (200 mg). They were taken half an hour before meals and once per day for 8wk. The changes of the visual acuity, subjective symptom, ocular surface disease index (OSDI), the tear film and optical coherence tomography were observed at 2, 4, 6, and 8wk before and after treatment...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27775101/incorporating-concomitant-medications-into-genome-wide-analyses-for-the-study-of-complex-disease-and-drug-response
#12
Hillary T Graham, Daniel M Rotroff, Skylar W Marvel, John B Buse, Tammy M Havener, Alyson G Wilson, Michael J Wagner, Alison A Motsinger-Reif
Given the high costs of conducting a drug-response trial, researchers are now aiming to use retrospective analyses to conduct genome-wide association studies (GWAS) to identify underlying genetic contributions to drug-response variation. To prevent confounding results from a GWAS to investigate drug response, it is necessary to account for concomitant medications, defined as any medication taken concurrently with the primary medication being investigated. We use data from the Action to Control Cardiovascular Disease (ACCORD) trial in order to implement a novel scoring procedure for incorporating concomitant medication information into a linear regression model in preparation for GWAS...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27757837/e2-er%C3%AE-inhibits-ppar%C3%AE-to-regulate-cell-proliferation-and-enhance-apoptosis-in-hep3b-hepatocellular-carcinoma
#13
Shu Nu Chang-Lee, Hsi-Hsien Hsu, Marthandam Asokan Shibu, Tsung-Jung Ho, Chih-Hao Tsai, Ming-Cheng Chen, Chuan-Chou Tu, Vijaya Padma Viswanadha, Wei- Wen Kuo, Chih-Yang Huang
Peroxisome proliferator-activated receptor-α (PPARα) is a member of the nuclear receptor superfamily involved in hepatocarcinogenesis in rodents. In previous studies on liver tumor tissues, PPARα mRNA expression was found to be significantly higher and overexpression of ERα inhibited the PPARα expression, cell-proliferation and also induced apoptosis in Hep3B cell. However, the role of ERβ is not known yet. Therefore, the aim of this study is to define the role of ERβ on PPARα in Hep3B cells. The effect of PPARα signaling cascade were monitored by inducing Hep3B cells by fenofibrate...
October 18, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27748605/dielectric-relaxation-study-at-ambient-and-elevated-pressure-of-the-modeled-lipophylic-drug-fenofibrate
#14
Grzegorz Szklarz, Karolina Adrjanowicz, Mateusz Dulski, Justyna Knapik, Marian Paluch
In this work, we have carefully investigated the molecular dynamics in the supercooled liquid and glassy states of the pharmaceutical agent fenofibrate. To do that dielectric relaxation studies at ambient and the elevated pressure were performed. Data collected at atmospheric pressure were found to be in a good agreement with that already reported in the literature. High-pressure studies enable us to distinguish the secondary relaxation processes of the different molecular origin. This includes (i) pressure insensitive $\gamma$-relaxation of the activation energy $E_a$=28 kJ/mol and (ii) $\beta$-relaxation that senses the density increase and originates most probably from the intermolecular movements ($E_a$=77 kJ/mol at 480 MPa)...
October 17, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27748179/a-systematic-review-and-meta-analysis-of-controlled-trials-on-the-effects-of-statin-and-fibrate-therapies-on-plasma-homocysteine-levels
#15
Amirhossein Sahebkar, Matteo Pirro, Željko Reiner, Arrigo Cicero, Gianna Ferretti, Mario Simental-Mendía, Luis E Simental-Mendía
BACKGROUND: Plasma homocysteine is an independent non-traditional risk factor for atherosclerotic cardiovascular disease. The impact of statin therapy on plasma homocysteine is not conclusive. OBJECTIVE: To evaluate the effect of statin therapy on plasma homocysteine concentrations in a systematic review and meta-analysis of controlled clinical trials. The secondary aim was to assess the comparative effect of statins versus fibrates on plasma homocysteine levels in head-to-head trials...
October 7, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27747681/mood-personality-and-behavior-changes-during-treatment-with-statins-a-case-series
#16
Stephanie Cham, Hayley J Koslik, Beatrice A Golomb
Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral changes remains limited. We sought to elicit information germane to natural history and characteristics of central nervous system/behavioral changes in apparent connection with statin and/or cholesterol-lowering drug use, and delineate mechanisms that may bear on an association. Participants (and/or proxies) self-referred with behavioral and/or mood changes in apparent association with statins completed a survey eliciting cholesterol-lowering drug history, character and impact of behavioral/mood effect, time-course of onset and recovery in relation to drug use/modification, co-occurrence of recognized statin-associated ADRs, and factors relevant to ADR causality determination...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27745542/fenofibrate-increases-heme-oxygenase-1-expression-and-astrocyte-proliferation-while-limits-neuronal-injury-during-intracerebral-hemorrhage
#17
Yan Wang, Min Yu, Yue Ma, Ruo Ping Wang, Wei Liu, Wei Xia, Ai Li Guan, Cong Hui Xing, Fei Lu, Xiao Ping Ji
Peroxisome proliferator-activated receptors alpha (PPARα) is a therapy target in atherosclerosis and cardiovascular diseases. However, anti-inflammatory effects of PPARα in intracerebral hemorrhage (ICH) remain unknown. We investigated the anti-inflammatory effects of fenofibrate, a ligand of PPARα, in ICH rat model. We found that engagement of fenofibrate increased nissl body and astrocytes, and reduced the neuronal damage, which was observed in paraffin section of ICH rat brain. Fenofibrate also promoted the proliferation of astrocytes that were isolated from adult rat brain...
October 14, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27744606/new-role-of-hispidulin-in-lipid-metabolism-ppar%C3%AE-activator
#18
Xinchi Wu, Juan Xu
Hispidulin is a naturally occurring flavonoid isolated from a traditional Chinese medicinal herb, Saussurea involucrata. In this study, the regulating role of hispidulin on the mRNA expression level of enzymes involved in lipid metabolism was examined in vitro and in vivo. Moreover, the in vivo lipid-modulating effect of hispidulin was compared with that of fenofibrate, a classical PPARα agonist. Our results in present study demonstrated that hispidulin can directly bind to and activate PPARα as an agonist and thus modulate the downstream lipid-metabolizing genes...
November 2016: Lipids
https://www.readbyqxmd.com/read/27742378/a-system-for-in%C3%A2-vivo-imaging-of-hepatic-free-fatty-acid-uptake
#19
Hyo Min Park, Kim A Russo, Grigory Karateev, Michael Park, Elena Dubikovskaya, Lance J Kriegsfeld, Andreas Stahl
Alterations in hepatic free fatty acid (FFA) uptake and metabolism contribute to the development of prevalent liver disorders such as hepatosteatosis. However, detecting dynamic changes in FFA uptake by the liver in live model organisms has proven difficult. To enable noninvasive real-time imaging of FFA flux in the liver, we generated transgenic mice with liver-specific expression of luciferase and performed bioluminescence imaging with an FFA probe. Our approach enabled us to observe the changes in FFA hepatic uptake under different physiological conditions in live animals...
October 11, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27727958/efficacy-of-rosuvastatin-plus-fenofibrate-versus-rosuvastatin-plus-omega-3-fatty-acid-therapy-in-mixed-dyslipidemia
#20
B S Bal, Ashok Duggal, Mandeep Kaur, Sarabjit Singh, Tajinder Kaur
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
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