keyword
MENU ▼
Read by QxMD icon Read
search

noggin

keyword
https://www.readbyqxmd.com/read/29667005/the-bmp-2-mutant-l51p-a-bmp-receptor-ia-binding-deficient-inhibitor-of-noggin
#1
REVIEW
Hany Mohamed Khattab, Satoshi Kubota, Masaharu Takigawa, Takuo Kuboki, Walter Sebald
The antagonist-specific regulation in tissue engineering constitutes important attempts to achieve an improved and rapid bone regeneration by controlling the natural biological response of the natural body growth factors. L51P is molecularly engineered bone morphogentic protein-2 (BMP-2) variant with a substitution of the 51st leucine with a proline residue. L51P is deficient in BMP receptor binding, but maintains its structure and affinity for inhibitory proteins such as noggin, chordin, and gremlin. These modifications convert the BMP-2 variant L51P into a receptor-inactive inhibitor of BMP antagonists...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29587276/improving-bone-regeneration-using-chordin-sirna-delivered-by-ph-responsive-and-non-toxic-polyspermine-imidazole-4-5-imine
#2
Chuandong Wang, Fei Xiao, Yaokai Gan, Weien Yuan, Zhanjing Zhai, Tuo Jin, Xiaodong Chen, Xiaoling Zhang
BACKGROUND/AIMS: Bone nonunion remains a challenge for orthopaedists. The technological advancements that have been made in precisely silencing target genes have provided promising methods to address this challenge. METHODS: We detected the expression levels of the bone morphogenetic protein (BMP) inhibitors Chordin, Gremlin and Noggin using realtime PCR in bone mesenchymal stem cells (BMSCs) isolated from patients with normal fracture healing and those with bone nonunion...
March 21, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29577917/msx2-supports-epidermal-competency-during-wound-induced-hair-follicle-neogenesis
#3
Michael W Hughes, Ting-Xin Jiang, Maksim V Plikus, Christian Fernando Guerrero-Juarez, Chein-Hong Lin, Christopher Schafer, Robert Maxson, Randall B Widelitz, Cheng-Ming Chuong
Cutaneous wounds in adult mammals typically heal by scarring. However, large full-thickness wounds undergo wound-induced hair follicle neogenesis (WIHN), a novel form of regeneration. Here, we demonstrate WIHN requires transient expression of epidermal Msx2 in two phases; the wound margin early and the wound center late. Msx2 expression is present in the migrating epithelium during early wound healing, and then presents in the epithelium and mesenchyme later in the wound center. WIHN is abrogated in germline and epithelial-specific Msx2 mutant mice...
March 22, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29576501/intrastriatal-transplantation-of-stem-cells-from-human-exfoliated-deciduous-teeth-reduces-motor-defects-in-parkinsonian-rats
#4
Nan Zhang, Xianjie Lu, Shichao Wu, Xueli Li, Jing Duan, Chao Chen, Wei Wang, Hao Song, Jiabei Tong, Sen Li, Yanming Liu, Xinjiang Kang, Xuexiang Wang, Fabin Han
BACKGROUND: This study explored the neural differentiation and therapeutic effects of stem cells from human exfoliated deciduous teeth (SHED) in a rat model of Parkinson's disease (PD). METHODS: The SHED were isolated from fresh dental pulp and were induced to differentiate to neurons and dopamine neurons by inhibiting similar mothers against dpp (SMAD) signaling with Noggin and increase conversion of dopamine neurons from SHED with CHIR99021, Sonic Hedgehog (SHH) and FGF8 in vitro...
March 22, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29572187/joggin-the-noggin-towards-a-physiological-understanding-of-exercise-induced-cognitive-benefits
#5
REVIEW
Nikolas J Stimpson, Glen Davison, Amir-Homayoun Javadi
This narrative review examines literature pertaining to possible physiological explanations for observed cognitive benefits stemming from improvements to cardiovascular fitness following chronic aerobic exercise. Studies regarding exercise and cardiovascular fitness, angiogenesis, neuroinflammation in relation to IGF-1 signalling, regulation of neurotrophins, neurogenesis and plasticity, cognitive training, are briefly described. We propose that current evidence points towards a mechanism by which cardiovascular fitness improvements act to promote long-term angiogenesis and cerebral circulation...
March 20, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29564941/gene-expression-and-localization-of-lamtor3-in-the-skin-cells-of-liaoning-cashmere-goats
#6
Mei Jin, Ming Cao, Mingxing Chu, Jing'ai Piao, Xu Guo, Fengqin Zhao, Jun Piao
Liaoning cashmere goats are the most precious genetic resources in China. The function of LAMTOR3 [late endosomal/lysosomal adaptor, mitogen-activated protein kinase (MAPK), and mammalian target of rapamycin activator 3/MAPK scaffold protein 1] gene is expressed in the skin of Liaoning cashmere goats. In situ hybridization (ISH) found that LAMTOR3 is expressed in the inner root sheath (IRS) of hair follicles. During the anagen or catagen phase, the expression of LAMTOR3 is higher in secondary hair follicles than in primary hair follicles...
March 22, 2018: Animal Biotechnology
https://www.readbyqxmd.com/read/29563538/ucma-grp-inhibits-phosphate-induced-vascular-smooth-muscle-cell-calcification-via-smad-dependent-bmp-signalling
#7
Brecht A Willems, Malgorzata Furmanik, Marjolein M J Caron, Martijn L L Chatrou, Dennis H M Kusters, Tim J M Welting, Michael Stock, Marta S Rafael, Carla S B Viegas, Dina C Simes, Cees Vermeer, Chris P M Reutelingsperger, Leon J Schurgers
Vascular calcification (VC) is the process of deposition of calcium phosphate crystals in the blood vessel wall, with a central role for vascular smooth muscle cells (VSMCs). VC is highly prevalent in chronic kidney disease (CKD) patients and thought, in part, to be induced by phosphate imbalance. The molecular mechanisms that regulate VC are not fully known. Here we propose a novel role for the mineralisation regulator Ucma/GRP (Upper zone of growth plate and Cartilage Matrix Associated protein/Gla Rich Protein) in phosphate-induced VSMC calcification...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29559302/myo-nog-cells-are-present-in-the-ciliary-processes-on-the-zonule-of-zinn-and-posterior-capsule-of-the-lens-following-cataract-surgery
#8
Jacquelyn Gerhart, Colleen Withers, Colby Gerhart, Liliana Werner, Nick Mamalis, Arturo Bravo-Nuevo, Victoria Scheinfeld, Paul FitzGerald, Robert Getts, Mindy George-Weinstein
Myo/Nog cells, named for their expression of MyoD and noggin, enter the eye during early stages of embryonic development. Their release of noggin is critical for normal morphogenesis of the lens and retina. Myo/Nog cells are also present in adult eyes. Single nucleated skeletal muscle cells designated as myofibroblasts arise from Myo/Nog cells in cultures of lens tissue. In this report we document the presence of Myo/Nog cells in the lens, ciliary body and on the zonule of Zinn in mice, rabbits and humans. Myo/Nog cells were rare in all three structures...
March 17, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29545164/interaction-between-orexin-a-and-bone-morphogenetic-protein-system-on-progesterone-biosynthesis-by-rat-granulosa-cells
#9
Shiho Fujita, Toru Hasegawa, Yuki Nishiyama, Satoshi Fujisawa, Yasuhiro Nakano, Takahiro Nada, Nahoko Iwata, Yasuhiko Kamada, Hisashi Masuyama, Fumio Otsuka
The involvement of orexins in reproductive function has been gradually uncovered. However, the functional role of orexins in ovarian steroidogenesis remains unclear. In the present study, we investigated the effects of orexin A on ovarian steroidogenesis by using rat primary granulosa cells that express both OX1 and OX2 receptors for orexins. Treatment with orexin A enhanced progesterone, but not estradiol, biosynthesis induced by FSH, whereas it did not affect basal levels of progesterone or estradiol. In accordance with the effects on steroidogenesis, orexin A increased the mRNA levels of progesterogenic enzymes, including StAR, P450scc and 3βHSD, but not P450arom, and cellular cAMP synthesis induced by FSH...
March 12, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29509914/culture-and-characterization-of-chicken-small-intestinal-crypts
#10
J Li, J Li, S Y Zhang, R X Li, X Lin, Y L Mi, C Q Zhang
The integrity and normal function of the small intestinal epithelium depends critically on the rapid renewal of epithelial cells from basal stem cells. The intensive proliferation that fuels this self-renewal process is confined to the intestinal crypts. Establishment of suitable protocols for crypt isolation and culture is pivotal for the studies of intestinal self-renewal mechanisms. In this study, chicken small intestinal crypts were isolated, purified, and further cultured in a Matrigel 3-D culture system...
March 1, 2018: Poultry Science
https://www.readbyqxmd.com/read/29497255/molecular-docking-based-screening-of-noggin-inhibitors
#11
Sindhura Gudipati, Ravi Muttineni, Archana Uday Mankad, Himanshu Aniruddha Pandya, Yogesh Trilokinath Jasrai
Noggin (NOG) a BMP (bone morphogenetic protein) antagonist plays a key role in preferentially driving a subset of breast cancer cells towards the bone and causing osteolytic lesions leading to severe pain and discomfort in the patients. Owing to its role in bone metastasis, NOG could be promising molecular target in bone metastasis and that identifying small molecule inhibitors could aid in the treatment. Towards identifying cognate inhibitors of NOG, structure based virtual screen was employed. A total of 8...
2018: Bioinformation
https://www.readbyqxmd.com/read/29471239/identification-of-mir-200c-3p-as-a-major-regulator-of-saos2-cells-activation-induced-by-fluoride
#12
Yuting Jiang, Yanmei Yang, Hongge Wang, Gottfried M Darko, Dianjun Sun, Yanhui Gao
The skeletal lesion of fluoride has become a major concern in many countries due to its damage to bone and joints and even leading to disability. Skeletal fluorosis is characterized by disturbance of bone metabolism, aberrant proliferation and activation of osteoblasts is critical for the pathogenesis. However, the mechanism underlying the osteotoxicity of fluoride has not been clearly illustrated and there is still limited information on the role of miRNAs in skeletal fluorosis. In this study, we found that NaF promoted SaoS2 proliferation and activation by activating BMP4/Smad pathway...
February 19, 2018: Chemosphere
https://www.readbyqxmd.com/read/29467016/advancing-osteochondral-tissue-engineering-bone-morphogenetic-protein-transforming-growth-factor-and-fibroblast-growth-factor-signaling-drive-ordered-differentiation-of-periosteal-cells-resulting-in-stable-cartilage-and-bone-formation-in-vivo
#13
L F Mendes, H Katagiri, W L Tam, Y C Chai, L Geris, S J Roberts, F P Luyten
BACKGROUND: Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects. In this study, self-assembling tissue intermediates (TIs) derived from human periosteum-derived stem/progenitor cells (hPDCs) were generated and validated for stable cartilage formation in vivo using two different animal models. METHODS: hPDCs were aggregated and cultured in the presence of a novel growth factor (GF) cocktail comprising of transforming growth factor (TGF)-β1, bone morphogenetic protein (BMP)2, growth differentiation factor (GDF)5, BMP6, and fibroblast growth factor (FGF)2...
February 21, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29458046/bmp-2-induces-angiogenesis-by-provoking-integrin-%C3%AE-6-expression-in-human-endothelial-progenitor-cells
#14
Wei-Cheng Chen, Ching-Hu Chung, Yung-Chang Lu, Min-Huan Wu, Po-Hsun Chou, Juei-Yu Yen, Yu-Wei Lai, Guo-Shou Wang, Shih-Chia Liu, Jen-Kun Cheng, Yih-Jer Wu, Hung-I Yeh, Li-Yu Wang, Shih-Wei Wang
Bone morphogenetic proteins-2 (BMP-2) is a multifunctional cytokine, capable of governing several cellular functions, including proliferation, motility, differentiation, and angiogenesis. Circulating endothelial progenitor cells (EPCs) have been shown to facilitate tissue repair, postnatal neovascularization, and tumor associated angiogenesis. Nevertheless, the impact of BMP-2 on angiogenesis of human EPCs has largely remained a mystery. In this study, we found that BMP-2 promoted cell migration and tube formation of EPCs in a concentration-dependent manner, indicating BMP-2 induced in vitro angiogenesis in human EPCs...
February 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29454361/wnt-signaling-enhances-neural-crest-migration-of-melanoma-cells-and-induces-an-invasive-phenotype
#15
Tobias Sinnberg, Mitchell P Levesque, Jelena Krochmann, Phil F Cheng, Kristian Ikenberg, Francisco Meraz-Torres, Heike Niessner, Claus Garbe, Christian Busch
BACKGROUND: During embryonic development Wnt family members and bone morphogenetic proteins (BMPs) cooperatively induce epithelial-mesenchymal transition (EMT) in the neural crest. Wnt and BMPs are reactivated during malignant transformation in melanoma. We previously demonstrated that the BMP-antagonist noggin blocked the EMT phenotype of melanoma cells in the neural crest and malignant invasion of melanoma cells in the chick embryo; vice-versa, malignant invasion was induced in human melanocytes in vivo by pre-treatment with BMP-2...
February 17, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29436597/the-interplay-of-bmp4-and-il%C3%A2-7-regulates-the-apoptosis-of-intestinal-intraepithelial-lymphocytes-under-conditions-of-ischemia%C3%AC-reperfusion
#16
Binyu Luo, Kang Chen, Qi Feng, Weidong Xiao, Dan Ma, Hua Yang, Chaojun Zhang
The number and function of intestinal intraepithelial lymphocytes (IELs) have been found to be significantly reduced following induction of acute intestinal mucosal damage via intestinal ischemia̸reperfusion (I̸R). However, the mechanism underlying this reduction remains unclear. Therefore, it was hypothesized that the interplay of bone morphogenetic protein (BMP)4 and interleukin (IL)‑7 regulates IEL function and number. Recent studies have demonstrated that the different components of the BMP2̸4 signaling pathway are expressed in intestinal epithelial cells (IECs) via the activation of nuclear factor (NF)‑κB...
February 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29407213/iron-released-from-reactive-microglia-by-noggin-improves-myelin-repair-in-the-ischemic-brain
#17
Jin A Shin, Yul A Kim, Hye Won Kim, Hee-Sun Kim, Kyung-Eun Lee, Jihee Lee Kang, Eun-Mi Park
We previously reported that the bone morphogenetic protein (BMP) antagonist, noggin, improved the repair process with an increase in the reactive microglia/macrophage population in the ischemic brain. Since BMP plays a role in intracellular iron homeostasis via the hepcidin/ferroportin axis, and iron is required for myelination, this study was aimed to determine whether noggin affected iron status and remyelination in the brain following ischemic stroke. We further examined the effect of blocking the BMP/hepcidin pathway on reactive microglia (BV2) and myelination of oligodendroglial cells (MO3...
January 30, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29400080/chronic-intermittent-hypobaric-hypoxia-provides-vascular-protection-in-aorta-of-two-kidney-one-clip-rat-model-of-hypertension
#18
Fu Congrui, Li Na, Yuan Yujia, Wang Ri, Chen Jinting, Yang Jing, Guo Zan, Wang Sheng, Zhang Yi, Liu Yixian, Dong Jinghui
Many studies have demonstrated that chronic intermittent hypobaric hypoxia (CIHH) can reduce blood pressure in spontaneously hypertensive rats and renovascular hypertensive (RVH) rats in which endothelial dysfunction is determined as a critical factor. However, whether CIHH can regulate vasodilation of the aorta in RVH rats remains unknown. The purpose of this study was to investigate the effect of CIHH on impaired relaxation of the aorta in the two-kidney one-clip (2K1C) RVH rat model. The results showed CIHH improved the impaired endothelium-dependent relaxation in the 2K1C rat aorta...
February 3, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29396910/superior-bone-inducing-potential-of-rhbmp9-compared-to-rhbmp2
#19
Masako Fujioka-Kobayashi, Mustafa Abd El Raouf, Nikola Saulacic, Eizaburo Kobayashi, Yufeng Zhang, Benoit Schaller, Richard J Miron
Recombinant human bone morphogenic protein (rhBMP) 9 has recently been reported to have more osteopromotive potential in vitro when compared to rhBMP2. The aim of the present study was to investigate the bone-inducing potential of rhBMP2 and rhBMP9. We compared rhBMP2, rhBMP7 and rhBMP9 at 5 different concentrations and showed convincingly that rhBMP9 possesses much greater potential for osteoblast differentiation even at 20 times lower concentrations in vitro. We further show that Noggin, an inhibitor for rhBMP2-induced osteogenesis, did not alter rhBMP9-induced osteogenesis...
February 2, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29393426/endoglin-cd105-and-smad4-regulate-spheroid-formation-and-the-suppression-of-the-invasive-ability-of-human-pancreatic-cancer-cells
#20
Eri Kokaji, Akiko Shimomura, Takashi Minamisaka, Takahiko Nakajima, Shigeharu Miwa, Hideki Hatta, Takeshi Nishida, Chieko Kiya, Johji Imura
In this study, we investigated the ability of pancreatic cancer cell lines to form spheroids with the aim of identifying factors involved in cell invasiveness, a property that leads to a poor prognosis in pancreatic cancer. For this purpose, 8 cell lines derived from human pancreatic cancer tissues were cultured in non-adherent culture conditions to form spheroids, as well as normal monolayers. The morphology of the cells was observed and spheroid diameters measured. mRNA expression was compared between cells cultured under both culture conditions...
February 1, 2018: International Journal of Oncology
keyword
keyword
67589
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"