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https://read.qxmd.com/read/38534961/adult-neoneurogenesis-and-oligodendrogenesis-in-multiple-sclerosis-a-systematic-review-of-human-and-animal-studies
#1
JOURNAL ARTICLE
Andreas Liampas, Vasilis-Spyridon Tseriotis, Artemios Artemiadis, Panagiotis Zis, Chrysanthi Argyropoulou, Nikolaos Grigoriadis, Georgios M Hadjigeorgiou, Georgios Vavougyios
INTRODUCTION: The subventricular zone promotes remyelination through activation differentiation of oligodendroglial precursor cells (OPCs) and neural stem cells (NSCs) into mature oligodendrocytes and thus in the adult brain. In Multiple Sclerosis (MS) this regenerative capability in halted resulting in neurodegeneration. We aimed to systematically search and synthesize evidence on mechanisms and phenomena associated with SVZ dysfunction in MS. MATERIALS AND METHODS: Our systematic review was reported according to the PRISMA-ScR statement...
March 27, 2024: Brain Connectivity
https://read.qxmd.com/read/38529498/hb-egf-and-egf-infusion-following-cns-demyelination-mitigates-age-related-decline-in-regeneration-of-oligodendrocytes-from-neural-precursor-cells-originating-in-the-ventricular-subventricular-zone
#2
Kaveh Moradi, Stanislaw Mitew, Yao Lulu Xing, Tobias D Merson
In multiple sclerosis (MS), chronic demyelination initiated by immune-mediated destruction of myelin, leads to axonal damage and neuronal cell death, resulting in a progressive decline in neurological function. The development of interventions that potentiate remyelination could hold promise as a novel treatment strategy for MS. To this end, our group has demonstrated that neural precursor cells (NPCs) residing in the ventricular-subventricular zone (V-SVZ) of the adult mouse brain contribute significantly to remyelination in response to central nervous system (CNS) demyelination and can regenerate myelin of normal thickness...
February 28, 2024: bioRxiv
https://read.qxmd.com/read/38525876/dysregulation-of-mtor-signaling-mediates-common-neurite-and-migration-defects-in-both-idiopathic-and-16p11-2-deletion-autism-neural-precursor-cells
#3
JOURNAL ARTICLE
Smrithi Prem, Bharati Dev, Cynthia Peng, Monal Mehta, Rohan Alibutud, Robert J Connacher, Madeline St Thomas, Xiaofeng Zhou, Paul Matteson, Jinchuan Xing, James H Millonig, Emanuel DiCicco-Bloom
Autism spectrum disorder (ASD) is defined by common behavioral characteristics, raising the possibility of shared pathogenic mechanisms. Yet, vast clinical and etiological heterogeneity suggests personalized phenotypes. Surprisingly, our iPSC studies find that six individuals from two distinct ASD-subtypes, idiopathic and 16p11.2 deletion, have common reductions in neural precursor cell (NPC) neurite outgrowth and migration even though whole genome sequencing demonstrates no genetic overlap between the datasets...
March 25, 2024: ELife
https://read.qxmd.com/read/38509253/multiple-cell-lineages-give-rise-to-a-cell-type
#4
JOURNAL ARTICLE
Hisato Kondoh
It has long been assumed that a specific cell type arises following stepwise specification of cells corresponding to the branching of cell lineages. However, accumulating evidence indicates that multiple and even remote cell lineages can lead to the development of the same cells. Four examples giving different yet new insights will be discussed: skeletal muscle development from precursors with distinct initial histories of transcriptional regulation, lens cell development from remote lineages yet sharing basic transcription factors, blood cell development under intersectional pathways, and neural tissue development from cardiac precursors through the manipulation of just one component of epigenetic regulation...
2024: Results and Problems in Cell Differentiation
https://read.qxmd.com/read/38509251/gastrulation-its-principles-and-variations
#5
JOURNAL ARTICLE
Hisato Kondoh
As epiblast cells initiate development into various somatic cells, they undergo a large-scale reorganization, called gastrulation. The gastrulation of the epiblast cells produces three groups of cells: the endoderm layer, the collection of miscellaneous mesodermal tissues, and the ectodermal layer, which includes the neural, epidermal, and associated tissues. Most studies of gastrulation have focused on the formation of the tissues that provide the primary route for cell reorganization, that is, the primitive streak, in the chicken and mouse...
2024: Results and Problems in Cell Differentiation
https://read.qxmd.com/read/38497582/chronic-social-defeat-stress-induces-the-down-regulation-of-the-nedd4l-glt-1-ubiquitination-pathway-in-the-prefrontal-cortex-of-mice
#6
JOURNAL ARTICLE
Aika Kosuge, Kazuo Kunisawa, Tsubasa Iida, Bolati Wulaer, Tomoki Kawai, Moeka Tanabe, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
Stressful life events contribute to the onset of major depressive disorder (MDD). We recently demonstrated abnormalities in ubiquitination in the pathophysiology of MDD. However, the underlying molecular mechanisms remain unclear. We investigated the involvement of the ubiquitination system-mediated glutamatergic dysfunction in social impairment induced by chronic social defeat stress (CSDS). Adult C57BL/6J mice were exposed to aggressor ICR male mice for 10 consecutive days. Social impairment was induced by CSDS in the social interaction test 1 days after the last stress exposure...
March 18, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38491852/metabolomics-based-effects-of-a-natural-product-on-remyelination-after-cerebral-ischemia-injury-via-gababr-pcreb-bdnf-pathway
#7
JOURNAL ARTICLE
Xiaodi Fan, Min Zhan, Wenting Song, Mingjiang Yao, Guangrui Wang, Tian Li, Yehao Zhang, Jianxun Liu
BACKGROUND: Yi-Qi-Tong-Luo Granules (YQTLs) is a natural compound of Traditional Chinese Medicine authorized by China Food and Drug Administration (CFDA). These granules are employed in the convalescent stage of cerebral infarction and render notable clinical efficacy. This study aims to uncover the underlying mechanisms of YQTLs on remyelination after cerebral ischemia injury. MATERIALS AND METHODS: We established cerebral ischemia model in rats using microsphere-induced multiple cerebral infarction (MCI)...
March 16, 2024: Neurorehabilitation and Neural Repair
https://read.qxmd.com/read/38488548/oligodendrocytes-in-central-nervous-system-diseases-the-effect-of-cytokine-regulation
#8
JOURNAL ARTICLE
Chengfu Zhang, Mengsheng Qiu, Hui Fu
Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines are involved in nearly every aspect of cellular functions such as migration, survival, proliferation, and differentiation. Oligodendrocytes are the myelin-forming cells in the central nervous system and play critical roles in the conduction of action potentials, supply of metabolic components for axons, and other functions. Emerging evidence suggests that both oligodendrocytes and oligodendrocyte precursor cells are vulnerable to cytokines released under pathological conditions...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38487272/neural-conditional-ablation-of-the-protein-tyrosine-phosphatase-receptor-delta-ptprd-impairs-gliogenesis-in-the-developing-mouse-brain-cortex
#9
JOURNAL ARTICLE
Francisca Cornejo, Nayhara Franchini, Bastián I Cortés, Daniela Elgueta, Gonzalo I Cancino
Neurodevelopmental disorders are characterized by alterations in the development of the cerebral cortex, including aberrant changes in the number and function of neural cells. Although neurogenesis is one of the most studied cellular processes in these pathologies, little evidence is known about glial development. Genetic association studies have identified several genes associated with neurodevelopmental disorders. Indeed, variations in the PTPRD gene have been associated with numerous brain disorders, including autism spectrum disorder, restless leg syndrome, and schizophrenia...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38485895/circnrcam-up-regulates-nrcam-to-promote-papillary-thyroid-carcinoma-progression
#10
JOURNAL ARTICLE
C Wang, Z Wang, L Fu, J Du, F Ji, X Qiu
PURPOSE: Papillary Thyroid Carcinoma (PTC) is the most prevalent subtype of Thyroid Carcinoma (THCA), a type of malignancy in the endocrine system. According to prior studies, Neural Cell Adhesion Molecule (NRCAM) has been found to be up-regulated in PTC and stimulates the proliferation and migration of PTC cells. However, the specific mechanism of NRCAM in PTC cells is not yet fully understood. Consequently, this study aimed to investigate the underlying mechanism of NRCAM in PTC cells, the findings of which could provide new insights for the development of potential treatment targets for PTC...
March 14, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38485033/zeb2-alleviates-hirschsprung-s-associated-enterocolitis-by-promoting-the-proliferation-and-differentiation-of-enteric-neural-precursor-cells-via-the-notch-1-jagged-2-pathway
#11
JOURNAL ARTICLE
Yong Feng, Chonggao Zhou, Fan Zhao, Tidong Ma, Yong Xiao, Kun Peng, Renpeng Xia
BACKGROUND: Hirschsprung's-associated enterocolitis (HAEC) is a prevalent complication of Hirschsprung's disease (HSCR). Zinc finger E-box binding homeobox 2 (ZEB2) and Notch-1/Jagged-2 are dysregulated in HSCR, but their role in HAEC progression remains poorly understood. We aimed to explore the role and underlying mechanism of enteric neural precursor cells (ENPCs) and the ZEB2/Notch-1/Jagged-2 pathway in HAEC development. METHODS: Colon tissues were collected from HSCR and HAEC patients...
March 12, 2024: Gene
https://read.qxmd.com/read/38478163/rna-seq-time-course-analysis-of-neural-precursor-cell-transcriptome-in-response-to-herpes-simplex-virus-1-infection
#12
JOURNAL ARTICLE
Joel A Wood, Srilakshmi Chaparala, Cecilia Bantang, Ansuman Chattopadhyay, Maribeth A Wesesky, Paul R Kinchington, Vishwajit L Nimgaonkar, David C Bloom, Leonardo D'Aiuto
The neurogenic niches within the central nervous system serve as essential reservoirs for neural precursor cells (NPCs), playing a crucial role in neurogenesis. However, these NPCs are particularly vulnerable to infection by the herpes simplex virus 1 (HSV-1). In the present study, we investigated the changes in the transcriptome of NPCs in response to HSV-1 infection using bulk RNA-Seq, compared to those of uninfected samples, at different time points post infection and in the presence or absence of antivirals...
March 13, 2024: Journal of Neurovirology
https://read.qxmd.com/read/38470994/clickable-granular-hydrogel-scaffolds-for-delivery-of-neural-progenitor-cells-to-sites-of-spinal-cord-injury
#13
JOURNAL ARTICLE
Thomas J Tigner, Gabrielle Dampf, Ashley Tucker, Yu-Chi Huang, Vipin Jagrit, Abigail J Clevenger, Arpita Mohapatra, Shreya A Raghavan, Jennifer N Dulin, Daniel L Alge
Spinal cord injury (SCI) is a serious condition with limited treatment options. Neural progenitor cell (NPC) transplantation is a promising treatment option, and the identification of novel biomaterial scaffolds that support NPC engraftment and therapeutic activity is a top research priority. The objective of this study was to evaluate in situ assembled poly (ethylene glycol) (PEG)-based granular hydrogels for NPC delivery in a murine model of SCI. Microgel precursors were synthesized by using thiol-norbornene click chemistry to react four-armed PEG-amide-norbornene with enzymatically degradable and cell adhesive peptides...
March 12, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38454085/glial-restricted-precursors-stimulate-endogenous-cytogenesis-and-effectively-recover-emotional-deficits-in-a-model-of-cytogenesis-ablation
#14
JOURNAL ARTICLE
Joana Martins-Macedo, Bruna Araújo, Sandra I Anjo, Tiago Silveira-Rosa, Patrícia Patrício, Nuno Dinis Alves, Joana M Silva, Fábio G Teixeira, Bruno Manadas, Ana J Rodrigues, Angelo C Lepore, António J Salgado, Eduardo D Gomes, Luísa Pinto
Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and diseased states. To examine the role of newly formed glia, we transplanted Glial Restricted Precursors (GRPs) into the adult hippocampal dentate gyrus (DG), or injected their secreted factors (secretome), into a previously validated transgenic GFAP-tk rat line, in which cytogenesis is transiently compromised...
March 7, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38452824/sacral-neural-crest-independent-origin-of-the-enteric-nervous-system-in-mouse
#15
JOURNAL ARTICLE
Qi Yu, Li Liu, Mengjie Du, Daniel Müller, Yan Gu, Zhigang Gao, Xiaolong Xin, Yanlan Gu, Miao He, Till Marquardt, Liang Wang
BACKGROUND & AIMS: The enteric nervous system (ENS), the gut's intrinsic nervous system critical for gastrointestinal function and gut-brain communication, is believed to mainly originate from vagal neural crest cells (vNCCs) and partially from sacral NCCs (sNCCs). Resolving the exact origins of the ENS is critical for understanding congenital ENS diseases but has been confounded by the inability to distinguish between both NCC populations in situ. Here, we aimed to resolve the exact origins of the mammalian ENS...
March 5, 2024: Gastroenterology
https://read.qxmd.com/read/38437789/review-of-cellular-therapies-provides-new-insights-into-the-potential-treatment-of-diverse-neurologic-diseases-in-horses-and-dogs
#16
JOURNAL ARTICLE
Aimée C Colbath, Laurie Goodrich, Christopher Frye, Steven Dow
Neurological diseases and injuries in veterinary patients (horses, dogs, and cats) are complex, and effective treatment options are limited. Neuronal loss, damage to nerve conduction pathways, and inflammation and scarring associated with spinal cord injury pose major challenges in managing many neurological diseases. Furthermore, most of these neuropathologies lack definitive pharmacological treatments, driving interest and research into novel interventions. Our objective is to provide a narrative review of the current literature surrounding cellular therapies including neuronal and glial stem cells, neurotrophic factors, mesenchymal stem or stromal cells, and cells derived from induced pluripotent stem cells for the treatment of diverse neurological pathologies...
March 8, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38432304/gelma-hydrogel-as-a-scaffold-to-enhance-the-survival-and-differentiation-of-human-induced-lateral-ganglionic-eminence-precursor-cells
#17
JOURNAL ARTICLE
Linh Nguyen, Amy McCaughey-Chapman, Bronwen Connor
Cell reprogramming holds enormous potential to revolutionize our understanding of neurological and neurodevelopmental disorders, as well as enhance drug discovery and regenerative medicine. We have developed a direct cell reprogramming technology that allows us to generate lineage-specific neural cells. To extend our technology, we have investigated the incorporation of directly reprogrammed human lateral ganglionic eminence precursor cells (hiLGEPs) in a 3-dimensional (3D) matrix. Hydrogels are one of the most promising bio-scaffolds for 3D cell culture, providing cells with a supportive environment to adhere, proliferate, and differentiate...
March 1, 2024: Journal of Neuroscience Methods
https://read.qxmd.com/read/38425528/subcellular-protein-turnover-in-human-neural-progenitor-cells-revealed-by-correlative-electron-microscopy-and-nanoscale-secondary-ion-mass-spectrometry-imaging
#18
JOURNAL ARTICLE
Alicia A Lork, Stefania Rabasco, Carl Ernst, André du Toit, Silvio O Rizzoli, Nhu T N Phan
Protein turnover is a critical process for accurate cellular function, in which damaged proteins in the cells are gradually replaced with newly synthesized ones. Many previous studies on cellular protein turnover have used stable isotopic labelling by amino acids in cell culture (SILAC), followed by proteomic bulk analysis. However, this approach does not take into account the heterogeneity observed at the single-cell and subcellular levels. To address this, we investigated the protein turnover of neural progenitor cells at the subcellular resolution, using correlative TEM and NanoSIMS imaging, relying on a pulse-chase analysis of isotopically-labelled protein precusors...
February 28, 2024: Chemical Science
https://read.qxmd.com/read/38418090/lipotype-acquisition-during-neural-development-is-not-recapitulated-in-stem-cell-derived-neurons
#19
JOURNAL ARTICLE
Anusha B Gopalan, Lisa van Uden, Richard R Sprenger, Nadine Fernandez-Novel Marx, Helle Bogetofte, Pierre A Neveu, Morten Meyer, Kyung-Min Noh, Alba Diz-Muñoz, Christer S Ejsing
During development, different tissues acquire distinct lipotypes that are coupled to tissue function and homeostasis. In the brain, where complex membrane trafficking systems are required for neural function, specific glycerophospholipids, sphingolipids, and cholesterol are highly abundant, and defective lipid metabolism is associated with abnormal neural development and neurodegenerative disease. Notably, the production of specific lipotypes requires appropriate programming of the underlying lipid metabolic machinery during development, but when and how this occurs is unclear...
May 2024: Life Science Alliance
https://read.qxmd.com/read/38414797/anisotropic-microtopography-surface-of-chitosan-scaffold-regulating-skin-precursor-derived-schwann-cells-towards-repair-phenotype-promotes-neural-regeneration
#20
JOURNAL ARTICLE
Meng Cong, Xia Wu, Lingjie Zhu, Guohao Gu, Fei Ding, Guicai Li, Haiyan Shi
For repairing peripheral nerve and spinal cord defects, biomaterial scaffold-based cell-therapy was emerged as an effective strategy, requiring the positive response of seed cells to biomaterial substrate and environment signals. Previous work highlighted that the imposed surface properties of scaffold could provide important guidance cues to adhered cells for polarization. However, the insufficiency of native Schwann cells and unclear cellular response mechanisms remained to be addressed. Given that, this study aimed to illuminate the micropatterned chitosan-film action on the rat skin precursor-derived Schwann cells (SKP-SCs)...
2024: Regenerative Biomaterials
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