keyword
MENU ▼
Read by QxMD icon Read
search

Biomed

keyword
https://www.readbyqxmd.com/read/29468802/synergistic-effect-of-strontium-bioactive-glass-and-nano-hydroxyapatite-promotes-bone-regeneration-of-critical-sized-radial-bone-defects
#1
Ahmad Oryan, Mohamadreza Baghaban Eslaminejad, Amir Kamali, Samaneh Hosseini, Forough Azam Sayahpour, Hossein Baharvand
Critical-sized bone defects constitute a major health issue in orthopedics and usually cause mal-unions due to an inadequate number of migrated progenitor cells into the defect site or their incomplete differentiation into osteogenic precursor cells. The current study aimed to develop an optimized osteoinductive and angiogenic scaffold by incorporation of strontium (Sr) and bioglass (BG) into gelatin/nano-hydroxyapatite (G/nHAp) seeded with bone marrow mesenchymal stem cells to enhance bone regeneration. The scaffolds were fabricated by a freeze-drying technique and characterized in terms of morphology, structure, porosity and degradation rate...
February 21, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29466331/evolutionary-history-resolves-global-organization-of-root-functional-traits
#2
Zeqing Ma, Dali Guo, Xingliang Xu, Mingzhen Lu, Richard D Bardgett, David M Eissenstat, M Luke McCormack, Lars O Hedin
Plant roots have greatly diversified in form and function since the emergence of the first land plants, but the global organization of functional traits in roots remains poorly understood. Here we analyse a global dataset of 10 functionally important root traits in metabolically active first-order roots, collected from 369 species distributed across the natural plant communities of 7 biomes. Our results identify a high degree of organization of root traits across species and biomes, and reveal a pattern that differs from expectations based on previous studies of leaf traits...
February 21, 2018: Nature
https://www.readbyqxmd.com/read/29460346/comparison-of-the-ecarin-chromogenic-assay-and-diluted-thrombin-time-for-quantification-of-dabigatran-concentrations-comment
#3
R Marlu, T Jouve, B Polack, P Sié, V Mémier
We read with great interest the recent article by Jaffer et al. (1) comparing the ecarin chromogenic assay (ECA) and the diluted thrombin time (dTT) with high-performance liquid chromatography mass spectrometry assay (HPLC/MS) for the quantification of dabigatran concentrations in plasma. In this article, the ECA was performed using a STA-ECA-II kit with STA dabigatran calibrators (Diagnostica Stago, Asnières sur Seine, France) and dTT was performed using the Hemoclot Thrombin Inhibitor assay (HTI) (Hyphen BioMed, Neuville-sur-Oise, France)...
February 20, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29452334/seed-2-a-user-friendly-platform-for-amplicon-high-throughput-sequencing-data-analyses
#4
Tomáš Vetrovský, Petr Baldrian, Daniel Morais, Bonnie Berger
Motivation: Modern molecular methods have increased our ability to describe microbial communities. Along with the advances brought by new sequencing technologies, we now require intensive computational resources to make sense of the large numbers of sequences continuously produced. The software developed by the scientific community to address this demand, although very useful, require experience of the command-line environment, extensive training and have steep learning curves, limiting their use...
February 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29451714/development-of-regenerative-and-flexible-fibroin-based-wound-dressings
#5
Angelica Panico, Federica Paladini, Mauro Pollini
Skin injuries represent a health problem with consequences in terms of morbidity, disability and life quality. Numerous strategies have been developed for the treatment of wounds, including skin substitutes, biomembranes, scaffolds, and smart dressings. The excellent properties of fibroin can be exploited for the development of advanced wound dressing biomaterials, aiming at promoting the wound healing process. In this work, silk fibroin films modified through the addition of glucose were developed to enhance flexibility of medical device without affecting the biocompatibility, to promote wound healing and to improve the patient well-being...
February 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29451708/promotion-of-bone-regeneration-on-titanium-implants-through-a-chemical-treatment-process-using-calcium-phosphate-slurry-microscopic-analysis-cellular-response-and-animal-experiment
#6
Tatsuro Ito, Naofumi Ohtsu, Masanari Tomozawa, Mitsuhiro Hirano, Hiroko Takita, Tadashi Iizuka, Atsuro Yokoyama
The present study provides scientific evidence that a new chemical treatment process using calcium phosphate slurry promotes bone regeneration on titanium (Ti) implants. The material's surface modified by the treatment was analyzed using microscopic observation and the bone regeneration efficacy was evaluated both in vitro and in vivo. Formation of a thin hydroxyapatite layer with a thickness of about 50 nm and an increase of surface roughness were confirmed by microscopic observations. Histological evaluation of rat femora implanted with the specimens showed that the areas of the specimens directly attached to bone tissue were significantly more extensive than those implanted with control Ti at 2 and 8 weeks...
February 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29451044/endemic-and-emerging-acute-virus-infections-in-indonesia-an-overview-of-the-past-decade-and-implications-for-the-future
#7
Wesley de Jong, Musofa Rusli, Soerajja Bhoelan, Sofie Rohde, Fedik A Rantam, Purwati A Noeryoto, Usman Hadi, Eric C M van Gorp, Marco Goeijenbier
Being the largest archipelago country in the world, with a tropical climate and a unique flora and fauna, Indonesia habitats one of the most diverse biome in the world. These characteristics make Indonesia a popular travel destination, with tourism numbers increasing yearly. These characteristics also facilitate the transmission of zoonosis and provide ideal living and breading circumstances for arthropods, known vectors for viral diseases. A review of the past 10 years of literature, reports of the Ministry of Health, Republic of Indonesia and ProMED-mail shows a significant increase in dengue infection incidence...
February 16, 2018: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/29446542/novel-calcitonin-gene-related-peptide-chitosan-strontium-calcium-phosphate-cement-enhanced-proliferation-of-human-umbilical-vein-endothelial-cells-in-vitro
#8
Tiancheng Lv, Wei Liang, Li Li, Xu Cui, Xiaomou Wei, Haobo Pan, Bing Li
Bone cement materials have some disadvantages, including slow degradation and no biological activity, which greatly weakens their clinical application. Therefore, the search for a multifunctional bioactive bone cement has become urgent. In this study, a novel bone cement sample of calcitonin gene-related peptide (CGRP)/chitosan-strontium (Sr)-calcium phosphate cement (CPC) was developed. The structure and morphology were observed by scanning electron microscope (SEM). The cytotoxicity and proliferation of CGRP/chitosan-Sr-CPC were also measured...
February 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29444186/identification-of-fungi-in-shotgun-metagenomics-datasets
#9
Paul D Donovan, Gabriel Gonzalez, Desmond G Higgins, Geraldine Butler, Kimihito Ito
Metagenomics uses nucleic acid sequencing to characterize species diversity in different niches such as environmental biomes or the human microbiome. Most studies have used 16S rRNA amplicon sequencing to identify bacteria. However, the decreasing cost of sequencing has resulted in a gradual shift away from amplicon analyses and towards shotgun metagenomic sequencing. Shotgun metagenomic data can be used to identify a wide range of species, but have rarely been applied to fungal identification. Here, we develop a sequence classification pipeline, FindFungi, and use it to identify fungal sequences in public metagenome datasets...
2018: PloS One
https://www.readbyqxmd.com/read/29443454/voice-quality-outcomes-of-idiopathic-parkinson-disease-medical-treatment-a-systematic-review
#10
Jerome R Lechien, Serge Blecic, Kathy Huet, Véronique Delvaux, Myriam Piccaluga, Virginie Roland, Bernard Harmegnies, Sven Saussez
INTRODUCTION: To investigate voice quality (VQ) impairments in idiopathic Parkinson's disease (IPD) and to explore the impact of medical treatments and L-Dopa challenge testing on voice. METHODS: Relevant studies published between January 1980 and June 2017 describing VQ evaluations in IPD were retrieved using PubMed, Scopus, Biological Abstracts, BioMed Central, and Cochrane databases. Issues of clinical relevance, including IPD treatment efficiency and voice quality outcomes, were evaluated for each study...
February 14, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29437539/genotoxicity-of-turnera-subulata-and-spondias-mombin%C3%A2-%C3%A3-%C3%A2-spondias-tuberosa-extracts-from-brazilian-caatinga-biome
#11
Tiago Felipe Senes-Lopes, Jorge Alberto López, Viviane Souza do Amaral, José Brandão-Neto, Adriana Augusto de Rezende, Jefferson Romáryo Duarte da Luz, Zaira da Rosa Guterres, Maria das Graças Almeida
Medicinal plants have been used in primary healthcare since the earliest days of humankind. Turnera subulata and Spondias mombin × Spondias tuberosa are widely used in the Brazilian Northeast to treat several diseases. The aim of this study was to evaluate the genotoxic effects of the leaf extracts of these species by the somatic mutation and recombination test in the somatic cells of Drosophila melanogaster wings. The experiments were performed using standard and high-bioactivation cross and three concentrations of the test substance [aqueous extract (AET and AES) at 5...
February 13, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29437284/formation-of-osteon-like-structures-in-unidirectional-porous-hydroxyapatite-substitute
#12
Takeshi Makihara, Masataka Sakane, Hiroshi Noguchi, Toshinori Tsukanishi, Yasushi Suetsugu, Masashi Yamazaki
Unidirectional porous hydroxyapatite (UDPHAp) bone substitute comprises a microstructure of cross-sectionally oval pores with diameters ranging from 30 to 300 µm. Bone remodeling within the UDPHAp is expected upon implantation into bone; however, the mechanism and factors influencing this bone growth remain unclear. The objectives of the present study were to assess the vasculature and microstructure of newly formed bone and to determine how bone formation is affected by load transfer and UDPHAp pore size...
February 13, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29436716/chemocoding-as-an-identification-tool-where-morphological-and-dna-based-methods-fall-short-inga-as-a-case-study
#13
María-José Endara, Phyllis D Coley, Natasha L Wiggins, Dale L Forrister, Gordon C Younkin, James A Nicholls, R Toby Pennington, Kyle G Dexter, Catherine A Kidner, Graham N Stone, Thomas A Kursar
The need for species identification and taxonomic discovery has led to the development of innovative technologies for large-scale plant identification. DNA barcoding has been useful, but fails to distinguish among many species in species-rich plant genera, particularly in tropical regions. Here, we show that chemical fingerprinting, or 'chemocoding', has great potential for plant identification in challenging tropical biomes. Using untargeted metabolomics in combination with multivariate analysis, we constructed species-level fingerprints, which we define as chemocoding...
February 13, 2018: New Phytologist
https://www.readbyqxmd.com/read/29434313/distributions-of-phytoplankton-carbohydrate-protein-and-lipid-in-the-world-oceans-from-satellite-ocean-colour
#14
Shovonlal Roy
Energy value of phytoplankton regulates the growth of higher trophic species, affecting the tropic balance and sustainability of marine food webs. Therefore, developing our capability to estimate and monitor, on a global scale, the concentrations of macromolecules that determine phytoplankton energy value, would be invaluable. Reported here are the first estimates of carbohydrate, protein, lipid, and overall energy value of phytoplankton in the world oceans, using ocean-colour data from satellites. The estimates are based on a novel bio-optical method that utilises satellite-derived bio-optical fingerprints of living phytoplankton combined with allometric relationships between phytoplankton cells and cellular macromolecular contents...
February 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29434266/future-global-productivity-will-be-affected-by-plant-trait-response-to-climate
#15
Nima Madani, John S Kimball, Ashley P Ballantyne, David L R Affleck, Peter M van Bodegom, Peter B Reich, Jens Kattge, Anna Sala, Mona Nazeri, Matthew O Jones, Maosheng Zhao, Steven W Running
Plant traits are both responsive to local climate and strong predictors of primary productivity. We hypothesized that future climate change might promote a shift in global plant traits resulting in changes in Gross Primary Productivity (GPP). We characterized the relationship between key plant traits, namely Specific Leaf Area (SLA), height, and seed mass, and local climate and primary productivity. We found that by 2070, tropical and arid ecosystems will be more suitable for plants with relatively lower canopy height, SLA and seed mass, while far northern latitudes will favor woody and taller plants than at present...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29428857/microbial-communities-associated-with-uranium-in-situ-recovery-mining-process-are-related-to-acid-mine-drainage-assemblages
#16
Thomas Coral, Michaël Descostes, Hélène De Boissezon, Rizlan Bernier-Latmani, Luiz Felippe de Alencastro, Pierre Rossi
A large fraction (47%) of the world's uranium is mined by a technique called "In Situ Recovery" (ISR). This mining technique involves the injection of a leaching fluid (acidic or alkaline) into a uranium-bearing aquifer and the pumping of the resulting solution through cation exchange columns for the recovery of dissolved uranium. The present study reports the in-depth alterations brought to autochthonous microbial communities during acidic ISR activities. Water samples were collected from a uranium roll-front deposit that is part of an ISR mine in operation (Tortkuduk, Kazakhstan)...
February 8, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29427851/the-effect-of-grazing-system-intensification-on-the-growth-and-meat-quality-of-beef-cattle-in-the-brazilian-atlantic-forest-biome
#17
P P A Oliveira, R R S Corte, S L Silva, P H M Rodriguez, L S Sakamoto, A F Pedroso, R R Tullio, A Berndt
This study was carried out to evaluate the effects of four levels of intensification of grazing systems: 1) degraded pasture - DP; 2) irrigated pasture with high stocking rate - IHS; 3) dryland pasture with high stocking rate - DHS; 4) dryland pasture with moderate stocking rate - DMS; on growth, muscle development and meat quality of Nellore steers (271±2.2kg of live body weight - BW; 15months old) during two consecutive periods (17 and 15months). The final BW, the average daily BW gain, the hot carcass weight and the dress percentage were greater (P<0...
February 7, 2018: Meat Science
https://www.readbyqxmd.com/read/29427545/evaluation-of-decellularized-xenogenic-porcine-auricular-cartilage-as-a-novel-biocompatible-filler
#18
Sung-Chan Shin, Hee Young Park, Nari Shin, Da-Woon Jung, Hyun-Keun Kwon, Ji Min Kim, Soo-Geun Wang, Jin-Choon Lee, Eui-Suk Sung, Gi Cheol Park, Byung-Joo Lee
Fillers are products that fill the space in soft tissues of the human body and actively used in the various medical fields. Unfortunately, most of the cost-effective commercially available fillers are synthetic and have limitations in terms of their biocompatibility. Here, we evaluated the possible application of decellularized xenogenic cartilage as a long-lasting material for soft tissue augmentation and compared it with two commercially available fillers Artesense (polymethylmethacrylate microspheres) and Radiesse (calcium hydroxyapatite [CaHa])...
February 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29424966/the-effects-of-bi-functional-anti-adhesion-scaffolds-on-flexor-tendon-healing-in-a-rabbit-model
#19
Janice C Y Liao, Min He, Aaron W T Gan, Feng Wen, Lay Poh Tan, Alphonsus K S Chong
Progressive tendon adhesion is a major challenge in flexor tendon repair. The authors developed a bifunctional anti-adhesion scaffold and hypothesized that its application would reduce adhesion formation and deliver mesenchymal stem cells (MSCs) to enhance tendon healing. The scaffold was fabricated by an electrospinning machine before surface modification. The flexor tendons of 29 New Zealand rabbits underwent surgical repair and randomized to control, scaffold and scaffold loaded with MSC group. At 3 and 8 weeks post-surgery, range of motion (ROM), biomechanical properties, and histology were examined...
February 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29424964/development-of-zwitterionic-sulfobetaine-block-copolymer-conjugation-strategies-for-reduced-platelet-deposition-in-respiratory-assist-devices
#20
Alexander D Malkin, Sang-Ho Ye, Evan J Lee, Xiguang Yang, Yang Zhu, Lara J Gamble, William J Federspiel, William R Wagner
Respiratory assist devices, that utilize ∼2 m2 of hollow fiber membranes (HFMs) to achieve desired gas transfer rates, have been limited in their adoption due to such blood biocompatibility limitations. This study reports two techniques for the functionalization and subsequent conjugation of zwitterionic sulfobetaine (SB) block copolymers to polymethylpentene (PMP) HFM surfaces with the intention of reducing thrombus formation in respiratory assist devices. Amine or hydroxyl functionalization of PMP HFMs (PMP-A or PMP-H) was accomplished using plasma-enhanced chemical vapor deposition...
February 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
keyword
keyword
6758
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"