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Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial

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https://www.readbyqxmd.com/read/27548724/any-future-for-fecal-microbiota-transplantation-as-treatment-strategy-for-inflammatory-bowel-diseases
#1
Patrizia Kump, Christoph Högenauer
Fecal microbiota transplantation (FMT) is a novel therapeutic procedure aiming at restoring a normal intestinal microbiota by application of fecal microorganisms from a healthy subject into the gastrointestinal tract of a patient. FMT is the most effective treatment for recurrent Clostridium difficile infections (CDI). These infections also occur in patients with inflammatory bowel diseases (IBDs), where case series demonstrated a successful treatment of CDI by FMT in 83-92% of patients. The effect of FMT on the activity of IBD has mainly been investigated in ulcerative colitis (UC) patients, including 3 randomized controlled trials...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/25857665/fecal-microbiota-transplantation-induces-remission-in-patients-with-active-ulcerative-colitis-in-a-randomized-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Paul Moayyedi, Michael G Surette, Peter T Kim, Josie Libertucci, Melanie Wolfe, Catherine Onischi, David Armstrong, John K Marshall, Zain Kassam, Walter Reinisch, Christine H Lee
BACKGROUND & AIMS: Ulcerative colitis (UC) is difficult to treat, and standard therapy does not always induce remission. Fecal microbiota transplantation (FMT) is an alternative approach that induced remission in small series of patients with active UC. We investigated its safety and efficacy in a placebo-controlled randomized trial. METHODS: We performed a parallel study of patients with active UC without infectious diarrhea. Participants were examined by flexible sigmoidoscopy when the study began and then were randomly assigned to groups that received FMT (50 mL, via enema, from healthy anonymous donors; n = 38) or placebo (50 mL water enema; n = 37) once weekly for 6 weeks...
July 2015: Gastroenterology
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