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stem cell, injury, regeneration

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https://www.readbyqxmd.com/read/29161590/skin-and-its-regenerative-powers-an-alliance-between-stem-cells-and-their-niche
#1
REVIEW
Kevin Andrew Uy Gonzales, Elaine Fuchs
Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A high demand is placed on renewal and regeneration of the skin's barrier in order to protect the body from infection and dehydration and to heal wounds. This review focuses on the epithelial stem cells of skin, where they come from, where they reside, and how they function in normal homeostasis and wound repair...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29155716/evaluation-of-injury-induced-senescence-and-in-vivo-reprogramming-in-the-skeletal-muscle
#2
Coralie Cazin, Aurelie Chiche, Han Li
Cellular senescence is a stress response that is characterized by a stable cellular growth arrest, which is important for many physiological and pathological processes, such as cancer and ageing. Recently, senescence has also been implicated in tissue repair and regeneration. Therefore, it has become increasingly critical to identify senescent cells in vivo. Senescence-associated β-galactosidase (SA-β-Gal) assay is the most widely used assay to detect senescent cells both in culture and in vivo. This assay is based on the increased lysosomal contents in the senescent cells, which allows the histochemical detection of lysosomal β-galactosidase activity at suboptimum pH (6 or 5...
October 26, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29150943/muscle-regeneration-potential-and-satellite-cell-activation-profile-during-recovery-following-hindlimb-immobilization-in-mice
#3
Maria Guitart, Josep Lloreta, Laura Mañas-Garcia, Esther Barreiro
Reduced muscle activity leads to muscle atrophy and function loss in patients and animal models. Satellite cells (SCs) are postnatal muscle stem cells that play a pivotal role in skeletal muscle regeneration following injury. The regenerative potential, satellite cell numbers, and markers during recovery following immobilization of the hindlimb for seven days were explored. In mice exposed to seven days of hindlimb immobilization, in those exposed to recovery (seven days, splint removal), and in contralateral control muscles, muscle precursor cells were isolated from all hindlimb muscles (fluorescence-activated cell sorting, FACS), and SCs and muscle regeneration were identified using immunofluorescence (gastrocnemius and soleus) and electron microscopy (EM, gastrocnemius)...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150595/notch1-signaling-activation-contributes-to-adult-hippocampal-neurogenesis-following-traumatic-brain-injury
#4
Ming Tu, Penglei Zhu, Shaobo Hu, Wei Wang, Zhipeng Su, Jiaqing Guan, Chongran Sun, Weiming Zheng
BACKGROUND Neural stem cells are reported to exist in the hippocampus of adult mammals and are important sources of neurons for repair. The Notch1 signaling pathway is considered as one of the important regulators of neural stem cells, but its role in adult brains is unclear. We aimed to describe the role of Notch1 signaling in the adult rat hippocampus after traumatic brain injury. MATERIAL AND METHODS The model rats were randomly divided into 4 groups as follows: sham, sham-TBI, sham-Ad-TBI, and NICD-Ad-TBI...
November 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29146144/drosophila-adult-muscle-development-and-regeneration
#5
REVIEW
Rajesh D Gunage, Nagaraju Dhanyasi, Heinrich Reichert, K VijayRaghavan
Myogenesis is a highly orchestrated, complex developmental process by which cell lineages that are mesodermal in origin generate differentiated multinucleate muscle cells as a final product. Considerable insight into the process of myogenesis has been obtained for the embryonic development of the larval muscles of Drosophila. More recently, the postembryonic development of the muscles of the adult fly has become a focus of experimental investigation of myogenesis since specific flight muscles of the fly manifest remarkable similarities to vertebrate muscles in their development and organization...
November 13, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29142862/three-dimensional-printing-for-craniomaxillofacial-regeneration
#6
REVIEW
Laura Gaviria, Joseph J Pearson, Sergio A Montelongo, Teja Guda, Joo L Ong
Craniomaxillofacial injuries produce complex wound environments involving various tissue types and treatment strategies. In a clinical setting, care is taken to properly irrigate and stabilize the injury, while grafts are molded in an attempt to maintain physiological functionality and cosmesis. This often requires multiple surgeries and grafts leading to added discomfort, pain and financial burden. Many of these injuries can lead to disfigurement and resultant loss of system function including mastication, respiration, and articulation, and these can lead to acute and long-term psychological impact on the patient...
October 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29142785/role-of-cord-blood-and-bone-marrow-mesenchymal-stem-cells-in-recent-deep-burn-a-case-control-prospective-study
#7
Wael Abo-Elkheir, Fawzy Hamza, Ahmed M Elmofty, Atef Emam, Magdy Abdl-Moktader, Sameh Elsherefy, Hala Gabr
RATIONALE: Burn injuries represent one of the major worldwide public health problems causing more severe physiological stress than other traumas. Effective treatment of burn injuries is mandatory to prevent the numerous life-threatening complications and possible disabilities. Stem cells, a population of multipotent cells retaining the properties of self-renewal and differentiation, are the main player in tissue regeneration after major trauma. Thus, they are thought to play a key role in wound healing inducing efficient and physiological skin regeneration...
2017: American Journal of Stem Cells
https://www.readbyqxmd.com/read/29135730/a-novel-secretome-biotherapeutic-influences-regeneration-in-critical-size-bone-defects
#8
Alexander J Burdette, Teja Guda, Michelle E Thompson, Richard Banas, Forest Sheppard
Severe traumatic injuries often result in critical size bone defects, which are unable to heal without treatment. Autologous grafting is the standard of care but requires additional surgeries for graft procurement. Amnion-derived multipotent progenitor cells release a secretome of biomolecules identified as integral to the process of bone regeneration and angiogenesis. This secretome is currently under development as a biotherapeutic. The efficacy of this secretome biotherapeutic was evaluated in vitro on the proliferation and migration of mesenchymal stem cells and osteoprogenitor cells as well as in vivo using a critical size rat calvarial defect model...
November 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29134948/effect-of-scaffold-morphology-and-cell-co-culture-on-tenogenic-differentiation-of-hadmsc-on-centrifugal-melt-electrospun-poly-l%C3%A2-lactic-acid-fibrous-meshes
#9
Shaohua Wu, Hao Peng, Xiuhong Li, Philipp N Streubel, Yong Liu, Bin Duan
Engineered tendon grafts offer a promising alternative for grafting during the reconstruction of complex tendon tears. The tissue-engineered tendon substitutes have the advantage of increased biosafety and the option to customize their biochemical and biophysical properties to promote tendon regeneration. In this study, we developed a novel centrifugal melt electrospinning (CME) technique, with the goal of optimizing the fabrication parameters to generate fibrous scaffolds for tendon tissue engineering. The effects of CME processing parameters, including rotational speed, voltage, and temperature, on fiber properties (i...
November 14, 2017: Biofabrication
https://www.readbyqxmd.com/read/29134575/impact-of-intramuscular-administration-of-lipid-soluble-and-water-soluble-vehicles-into-regenerating-muscle-at-the-distinct-phases-of-skeletal-muscle-regeneration
#10
Ratchakrit Srikuea, Kanokwan Suhatcho
Interpretation on the effectiveness of potential substances to enhance skeletal muscle regeneration is difficult if an inappropriate vehicle is administered, since vehicle administration can directly enhance or suppress regenerative capacity. In the current study, intramuscular administration of lipid-soluble and water-soluble vehicles into regenerating muscle at the distinct phases of skeletal muscle regeneration (regenerative vs. remodeling) were investigated. Tested vehicles included lipid-soluble [olive oil, (0...
November 13, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29134115/plant-stem-cells-in-cosmetics-current-trends-and-future-directions
#11
REVIEW
Sonia Trehan, Bozena Michniak-Kohn, Kavita Beri
Plant regeneration at the cellular and tissue level is a unique process. Similar to animals, the stem cells in plants have properties that help stimulate and regenerate plants after injury. The unique properties of plant stem cells have been a recent area of interest and focus both in developing new cosmetics and studying how these extracts/phytohormones will influence animal skin. This special report focuses on the current evidence-based trends in plant stem cell-based cosmetics and sheds light on the challenges that we need to overcome in order to see meaningful changes in human skin using topical cosmetics derived from plant stem cells...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29126016/go-and-stop-signals-for-glial-regeneration
#12
REVIEW
Alicia Hidalgo, Ann Logan
The regenerative response of ensheating glia to central nervous system (CNS) injury involves proliferation and differentiation, axonal re-enwrapment and some recovery of behaviour. Understanding this limited response could enable the enhancement of it. In Drosophila, the glial progenitor state is maintained by Notch, an activator of cell division and Prospero (Pros), a repressor. Injury provokes the activation of NFκB and up-regulation of Kon-tiki (Kon), driving cell proliferation. Homeostatic switch-off comes about as two negative feedback loops involving Pros terminate the response...
November 7, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29125510/regenerative-medicine-and-spina-bifida-recent-developments-in-induced-fetal-regeneration
#13
Dario O Fauza
Regenerative medicine as it applies to spina bifida is a multi-pronged endeavor involving spinal cord repair, tissue engineering and fetal regeneration, all of which can mutually overlap to variable extents. The efforts involving spinal cord repair, whether they be cell-based or not, are virtually indistinguishable from the enormous body of work related to spinal cord recovery after traumatic injury. Tissue engineering, on the other hand, can involve a variety of structures besides constructs used for covering the spina bifida defect, for example the urinary bladder, bone, muscle and skin...
October 20, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29125428/schwann-cells-and-mesenchymal-stem-cells-in-laminin-or-fibronectin-aligned-matrices-and-regeneration-across-a-critical-size-defect-of-15-mm-in-the-rat-sciatic-nerve
#14
Francisco Gonzalez-Perez, Joaquim Hernández, Claudia Heimann, James B Phillips, Esther Udina, Xavier Navarro
OBJECTIVE Artificial nerve guides are being developed to substitute for autograft repair after peripheral nerve injuries. However, the use of conduits is limited by the length of the gap that needs to be bridged, with the success of regeneration highly compromised in long gaps. Addition of aligned proregenerative cells and extracellular matrix (ECM) components inside the conduit can be a good strategy to achieve artificial grafts that recreate the natural environment offered by a nerve graft. The purpose of this study was to functionalize chitosan devices with different cell types to support regeneration in limiting gaps in the rat peripheral nerve...
November 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29125135/silk-fibroin-amniotic-membrane-3d-bi-layered-artificial-skin
#15
Mazaher Gholipourmalekabadi, A Samadikuchaksaraei, Alexander Marcus Seifalian, Aleksandra Urbanska, Hossein Ghanbarian, John George Hardy, Mir Omrani, Masoud Mozafari, Rui Luis Reis, Subhas Chandra Kundu
Burn injury has been reported to be an important cause of morbidity and mortality and it is still considered as unmet clinical need. Although there is a myriad of effective stem cells suggested for skin regeneration, there is no one ideal scaffold. The aim of this study was to develop a 3D bi-layer scaffold made of biological decellularized human amniotic membrane (AM) with viscoelastic electrospun nanofibrous silk fibroin (ESF) spun on top. The fabricated 3D bi-layer AM/ESF scaffold was submerged in ethanol to induce β-sheet transformation as well as to get a tightly coated and inseparable bilayer...
November 10, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29123981/coculture-of-endothelial-progenitor-cells-and-mesenchymal-stem-cells-enhanced-their-proliferation-and-angiogenesis-through-pdgf-and-notch-signaling
#16
Tangzhao Liang, Lei Zhu, Wenling Gao, Ming Gong, Jianhua Ren, Hui Yao, Kun Wang, Dehai Shi
The beneficial effects of combined use of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) on tissue repair and regeneration after injury have been demonstrated, but the underlying mechanism remains incompletely understood. This study aimed to investigate the effects of direct contact coculture of human bone marrow-derived EPCs (hEPCs)/human bone marrow-derived MSCs (hMSCs) on their proliferation and angiogenic capacities and the underlying mechanism. hEPCs and hMSCs were cocultured in a 2D mixed monolayer or a 3D transwell membrane cell-to-cell coculture system...
November 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29123544/non-coding-rnas-in-mesenchymal-stem-cell-derived-extracellular-vesicles-deciphering-regulatory-roles-in-stem-cell-potency-inflammatory-resolve-and-tissue-regeneration
#17
REVIEW
Farah Fatima, Karin Ekstrom, Irina Nazarenko, Marco Maugeri, Hadi Valadi, Andrew F Hill, Giovanni Camussi, Muhammad Nawaz
Extracellular vesicles (EVs) are heterogeneous populations of nano- and micro-sized vesicles secreted by various cell types. There is mounting evidence that EVs have widespread roles in transporting proteins, lipids, and nucleic acids between cells and serve as mediators of intercellular communication. EVs secreted from stem cells could function as paracrine factors, and appear to mimic and recapitulate several features of their secreting cells. EV-mediated transport of regulatory RNAs provides a novel source of trans-regulation between cells...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29118944/cardiac-progenitor-cells-application-in-cardiovascular-disease
#18
REVIEW
Hassan Amini, Jafar Rezaie, Armin Vosoughi, Reza Rahbarghazi, Mohammad Nouri
Stem cells (SCs) have special potency to differentiate into different types of cells, especially cardiomyocytes. In order to demonstrate the therapeutic applications of these cells, various investigations are recently being developed. Cardiac progenitor cells are endogenous cardiac SCs that found to express tyrosine kinase receptors, c-Kit and other stemness features in adult heart, contributing to the regeneration of cardiac tissue after injury. This lineage is able to efficiently trans-differentiate into different cell types such as cardiomyocytes, endothelial cells, and smooth muscle cells...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/29118330/molecular-spectrum-of-secretome-regulates-the-relative-hepatogenic-potential-of-mesenchymal-stem-cells-from-bone-marrow-and-dental-tissue
#19
Ajay Kumar, Vinod Kumar, Vidya Rattan, Vivekananda Jha, Arnab Pal, Shalmoli Bhattacharyya
Liver regeneration is a spontaneous process that occurs after liver injury, but acute liver failure is a complex and fatal disease which is difficult to treat. Cell-based therapies are promising alternative therapeutic approach for liver failure and different cell sources have been tested in this regard. We investigated the comparative hepatogenic potential of human bone marrow stem cells (BMSC) with stem cells derived from human dental pulp (DPSC), apical papilla (SCAP) and follicle (DFSC) during this study...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116017/regenerative-potential-of-primary-adult-human-neural-stem-cells-on-micropatterned-bio-implants-boosts-motor-recovery
#20
Carole Davoust, Benjamin Plas, Amélie Béduer, Boris Demain, Anne-Sophie Salabert, Jean Christophe Sol, Christophe Vieu, Laurence Vaysse, Isabelle Loubinoux
BACKGROUND: The adult brain is unable to regenerate itself sufficiently after large injuries. Therefore, hopes rely on therapies using neural stem cell or biomaterial transplantation to sustain brain reconstruction. The aim of the present study was to evaluate the improvement in sensorimotor recovery brought about by human primary adult neural stem cells (hNSCs) in combination with bio-implants. METHODS: hNSCs were pre-seeded on implants micropatterned for neurite guidance and inserted intracerebrally 2 weeks after a primary motor cortex lesion in rats...
November 7, 2017: Stem Cell Research & Therapy
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