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stem cell, injury, regeneration

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https://www.readbyqxmd.com/read/29345353/hipop-mesenchymal-population-has-high-potential-for-repairing-injured-peripheral-nerves
#1
Yukako Yamauchi, Shousaku Itoh, Haruna Naruse, Yuki Itoh, Makoto Abe, Takumi Kagioka, Mikako Hayashi
Bone marrow stromal cells (BMSCs) are reportedly a heterogeneous population of mesenchymal stem cells (MSCs). Recently, we developed a simple strategy for the enrichment of MSCs with the capacity to differentiate into osteoblasts, chondrocytes, and adipocytes. On transplantation, the progenitor-enriched fractions can regenerate the bone with multiple lineages of donor origin and are thus called "highly purified osteoprogenitors" (HipOPs). Although our previous studies have demonstrated that HipOPs are enriched with MSCs and exhibit a higher potential to differentiate into osteoblasts, adipocytes, and chondrocytes than BMSCs, their potential to differentiate into neural cells has not been clarified...
January 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29343270/isolation-and-characterization-of-olfactory-ecto-mesenchymal-stem-cells-from-eight-mammalian-genera
#2
Antoine D Veron, Cécile Bienboire-Frosini, François Feron, Elisa Codecasa, Arnaud Deveze, Dany Royer, Paul Watelet, Pietro Asproni, Kevin Sadelli, Camille Chabaud, Jean-Claude Stamegna, Joël Fagot, Michel Khrestchatisky, Alessandro Cozzi, François S Roman, Patrick Pageat, Manuel Mengoli, Stéphane D Girard
BACKGROUND: Stem cell-based therapies are an attractive option to promote regeneration and repair defective tissues and organs. Thanks to their multipotency, high proliferation rate and the lack of major ethical limitations, "olfactory ecto-mesenchymal stem cells" (OE-MSCs) have been described as a promising candidate to treat a variety of damaged tissues. Easily accessible in the nasal cavity of most mammals, these cells are highly suitable for autologous cell-based therapies and do not face issues associated with other stem cells...
January 17, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29343182/fibronectin-enhances-cartilage-repair-by-activating-progenitor-cells-through-integrin-%C3%A9-5%C3%AE-1-receptor
#3
Tianqi Tao, Yang Li, Chang Gui, Yong Ma, Yingbin Ge, Hanhao Dai, Kaibin Zhang, Jing Du, Yang Guo, Yiqiu Jiang, Jianchao Gui
This study aimed to determine the effect of fibronectin (FN) on cartilage regeneration through the activation of chondrogenic progenitor cells (CPCs). Cells were isolated from the knee cartilage of mice and cultured in the presence of various concentrations of FN. Proliferation, migration and chondrogenic differentiation assays were performed in vitro. In some experiments, CPCs were pre-incubated with anti-integrin ɑ5β1 antibody for 60 min prior to FN treatment to block the integrin ɑ5β1 receptor. Soluble FN was mixed with Pluronic F-127 and injected into the joint cavity in an early-stage osteoarthritis (OA) model...
January 18, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29341108/characteristics-of-tendon-derived-stem-cells-according-to-different-factors-to-induce-the-tendinopathy
#4
Sun Jeong Kim, Da-Hyun Song, Sang Jun Kim
Tendon derived stem cells (TDSCs) have been used as a therapeutic agent and as a healing marker. However, there has been no study about the characteristics of TDSCs extracted from tendinopathic tendon tissues. The aim of this study was to find the different characteristics of TDSCs according to the factors to induce the tendinopathy. Five- and 15-week old Sprague Dawley rats were used for this study and chemically-induced and injury-induced tendinopathy models were made depending on the age of the animal for different types of tendinopathy...
January 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29335337/salivary-glands-regenerate-after-radiation-injury-through-sox2-mediated-secretory-cell-replacement
#5
Elaine Emmerson, Alison J May, Lionel Berthoin, Noel Cruz-Pacheco, Sara Nathan, Aaron J Mattingly, Jolie L Chang, William R Ryan, Aaron D Tward, Sarah M Knox
Salivary gland acinar cells are routinely destroyed during radiation treatment for head and neck cancer that results in a lifetime of hyposalivation and co-morbidities. A potential regenerative strategy for replacing injured tissue is the reactivation of endogenous stem cells by targeted therapeutics. However, the identity of these cells, whether they are capable of regenerating the tissue, and the mechanisms by which they are regulated are unknown. Using in vivo and ex vivo models, in combination with genetic lineage tracing and human tissue, we discover a SOX2+ stem cell population essential to acinar cell maintenance that is capable of replenishing acini after radiation...
January 15, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29331939/volumetric-muscle-loss-injury-repair-using-in-situ-fibrin-gel-cast-seeded-with-muscle-derived-stem-cells-mdscs
#6
Nadine Matthias, Samuel D Hunt, Jianbo Wu, Jonathan Lo, Laura A Smith Callahan, Yong Li, Johnny Huard, Radbod Darabi
Volumetric muscle defect, caused by trauma or combat injuries, is a major health concern leading to severe morbidity. It is characterized by partial or full thickness loss of muscle and its bio-scaffold, resulting in extensive fibrosis and scar formation. Therefore, the ideal therapeutic option is to use stem cells combined with bio-scaffolds to restore muscle. For this purpose, muscle-derived stem cells (MDSCs) are a great candidate due to their unique multi-lineage differentiation potential. In this study, we evaluated the regeneration potential of MDSCs for muscle loss repair using a novel in situ fibrin gel casting...
January 9, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29329593/targeting-ectodysplasin-promotor-by-crispr-dcas9-effector-effectively-induces-the-reprogramming-of-human-bone-marrow-derived-mesenchymal-stem-cells-into-sweat-gland-like-cells
#7
Sujing Sun, Jun Xiao, Jiahui Huo, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing Fu
BACKGROUND: Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicity, bone marrow-derived mesenchymal stem cells (BM-MSCs) represent as an ideal biological source for cell therapy. The aim of this study was to identify whether targeting the promotor of ectodysplasin (EDA) by CRISPR/dCas9-effector (dCas9-E) could induce the BM-MSCs to differentiate into sweat gland-like cells (SGCs)...
January 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29327452/regenerative-effects-of-human-embryonic-stem-cell-derived-neural-crest-cells-for-treatment-of-peripheral-nerve-injury
#8
Iwan Jones, Liudmila N Novikova, Lev N Novikov, Monika Renardy, Andreas Ullrich, Mikael Wiberg, Leif Carlsson, Paul J Kingham
Surgical intervention is the current gold standard treatment following peripheral nerve injury. However, this approach has limitations and full recovery of both motor and sensory modalities often remains incomplete. The development of artificial nerve grafts that either complement or replace current surgical procedures is therefore of paramount importance. An essential component of artificial grafts are biodegradable conduits and transplanted cells that provide trophic support during the regenerative process...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29327429/in-vivo-migration-of-endogenous-brain-progenitor-cells-guided-by-an-injectable-peptide-amphiphile-biomaterial
#9
Reza Motalleb, Eric J Berns, Piyush Patel, Julie Gold, Samuel I Stupp, H Georg Kuhn
Biomaterials hold great promise in helping the adult brain regenerate and rebuild after trauma. Peptide amphiphiles (PA) are highly versatile biomaterials, gelling and forming macromolecular structures when exposed to physiological levels of electrolytes. We are here reporting on the first ever in vivo use of self-assembling peptide amphiphile carrying a Tenascin-C signal (E2 Ten-C PA) for the re-direction of endogenous neuroblasts in the rodent brain. The PA forms highly aligned nanofibers, displaying the migratory sequence of Tenascin-C glycoprotein as epitope...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29323053/roles-of-neural-stem-cells-in-the-repair-of-peripheral-nerve-injury
#10
REVIEW
Chong Wang, Chang-Feng Lu, Jiang Peng, Cheng-Dong Hu, Yu Wang
Currently, researchers are using neural stem cell transplantation to promote regeneration after peripheral nerve injury, as neural stem cells play an important role in peripheral nerve injury repair. This article reviews recent research progress of the role of neural stem cells in the repair of peripheral nerve injury. Neural stem cells can not only differentiate into neurons, astrocytes and oligodendrocytes, but can also differentiate into Schwann-like cells, which promote neurite outgrowth around the injury...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29320729/corneal-committed-cells-restore-the-stem-cell-pool-and-tissue-boundary-following-injury
#11
Waseem Nasser, Aya Amitai-Lange, Despina Soteriou, Rana Hanna, Beatrice Tiosano, Yaron Fuchs, Ruby Shalom-Feuerstein
During morphogenesis, preserving tissue boundaries is essential for cell fate regulation. While embryonic tissues possess high plasticity and repair ability, the questions of whether and how adult tissues cope with acute stem cell (SC) loss or boundary disruption have remained unanswered. Here, we report that K15-GFP transgene labels the murine corneal epithelial boundary and SC niche known as the limbus. K15-GFP+ basal cells expressed SC markers and were located at the corneal regeneration site, as evident by lineage tracing...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29318389/myogenic-potential-of-mesenchymal-stem-cells-isolated-from-porcine-adipose-tissue
#12
Derek J Milner, Massimo Bionaz, Elisa Monaco, Jo Ann Cameron, Matthew B Wheeler
Advances in stem cell biology and materials science have provided a basis for developing tissue engineering methods to repair muscle injury. Among stem cell populations with potential to aid muscle repair, adipose-derived mesenchymal stem cells (ASC) hold great promise. To evaluate the possibility of using porcine ASC for muscle regeneration studies, we co-cultured porcine ASC with murine C2C12 myoblasts. These experiments demonstrated that porcine ASC display significant myogenic potential. Co-culture of ASC expressing green fluorescent protein (GFP) with C2C12 cells resulted in GFP+ myotube formation, indicating fusion of ASC with myoblasts to form myotubes...
January 9, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29316535/the-hippo-pathway-in-organ-development-homeostasis-and-regeneration
#13
REVIEW
Vivian Fu, Steven W Plouffe, Kun-Liang Guan
The Hippo pathway is a universal governor of organ size, tissue homeostasis, and regeneration. A growing body of work has advanced our understanding of Hippo pathway regulation of cell proliferation, differentiation, and spatial patterning not only in organ development but also upon injury-induced regeneration. The pathway's central role in stem cell biology thus implicates its potential for therapeutic manipulation in mammalian organ regeneration. In this review, we survey recent literature linking the Hippo pathway to the development, homeostasis, and regeneration of various organs, including Hippo-independent roles for YAP, defined here as YAP functions that are not regulated by the Hippo pathway kinases LATS1/2...
January 6, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29315262/intraarticularly-injected-mesenchymal-stem-cells-stimulate-anti-inflammatory-molecules-and-inhibit-pain-related-protein-and-chondrolytic-enzymes-in-a-monoiodoacetate-induced-rat-arthritis-model
#14
Toru Ichiseki, Miyako Shimazaki, Yoshimichi Ueda, Shusuke Ueda, Masanobu Tsuchiya, Daisuke Souma, Ayumi Kaneuji, Norio Kawahara
Persistent inflammation is well known to promote the progression of arthropathy. mesenchymal stem cells (MSCs) have been shown to possess anti-inflammatory properties and tissue differentiation potency. Although the experience so far with the intraarticular administration of mesenchymal stem cell (MSC) to induce cartilage regeneration has been disappointing, MSC implantation is now being attempted using various surgical techniques. Meanwhile, prevention of osteoarthritis (OA) progression and pain control remain important components of the treatment of early-stage OA...
January 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29313037/soluble-collagen-vi-treatment-enhances-mesenchymal-stem-cells-expansion-for-engineering-cartilage
#15
Piera Smeriglio, Jieun Lee, Nidhi Bhutani
Bone Marrow-derived mesenchymal stem cells (BM-MSC) are an attractive source for cell-based therapies in cartilage injury owing to their efficient differentiation into chondrocytes and their immune-suppressive abilities. However, their clinical use is hampered by a scarcity of cells leading to compromised efficacy. While expansion of human MSC ex vivo can potentially overcome the scarcity of cells, current methods lead to a rapid loss of the stem cell properties. In this study, we report soluble Collagen VI (cartilage pericellular matrix component) as a potential biologic that can expand the MSC population while maintaining the stem cell phenotype as confirmed by expression of the stem cell markers CD105 and CD90...
September 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29312533/loss-of-pacs-2-delays-regeneration-in-dss-induced-colitis-but-does-not-affect-the-apcmin-model-of-colorectal-cancer
#16
Sarah L Dombernowsky, Jeanette Schwarz, Jacob Samsøe-Petersen, Reidar Albrechtsen, Kim B Jensen, Gary Thomas, Marie Kveiborg
PACS-2 is a multifunctional sorting protein that mediates cell homeostasis. We recently identified PACS-2 in a functional genome-wide siRNA screen for novel regulators of the metalloproteinase ADAM17, the main sheddase for ligands of the ErbB receptor family. Of note, we showed that Pacs2-/- mice have significantly reduced EGFR activity and proliferative index in the intestinal epithelium. As EGFR signaling is highly mitogenic for intestinal epithelial stem cells, and plays essential roles in intestinal epithelial regeneration and tumor development, we have now examined the role of PACS-2 in these processes...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310519/intranasal-stem-cell-treatment-as-a-novel-therapy-for-subarachnoid-hemorrhage
#17
Cora H Nijboer, Elke Kooijman, Cindy T van Velthoven, Erik Van Tilborg, Ivo A Tiebosch, Niels Eijkelkamp, Rick M Dijkhuizen, Jozef Kesecioglu, Cobi Heijnen
Subarachnoid hemorrhage (SAH) represents a major health problem in Western society due to high mortality and morbidity, and the relative young age of patients. Currently, efficacious therapeutic options are very limited. Mesenchymal stem cell (MSC) administration has been shown to improve functional outcome and lesion size in experimental models of stroke and neonatal hypoxic-ischemic brain injury. Here we studied the therapeutic potential of intranasally administered bone marrow-derived MSCs relatively late post-insult using a rat endovascular puncture model for SAH...
January 8, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29305004/translational-control-of-the-myogenic-program-in-developing-regenerating-and-diseased-skeletal-muscle
#18
Ryo Fujita, Colin Crist
Translational control of genes that code for protein allows a cell to rapidly respond to changes in its environment, in part because translational control of gene expression does not depend on upstream events required to produce an mRNA molecule. The importance of translational control has been highlighted by studies concerning muscle development, regeneration, and disease. Translational control of specific mRNAs is achieved by microRNAs and RNA-binding proteins, which are particularly relevant to developmental myogenesis, where they ensure the stepwise differentiation of multipotent progenitors to committed myogenic progenitors that ultimately fuse into slow- or fast-type myofibers that make up skeletal muscle...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29305003/muscle-stem-cells-and-aging
#19
Ara B Hwang, Andrew S Brack
Satellite cells (SCs) are a population of muscle-resident stem cells that are essential for efficient tissue repair. SCs reside in a relatively quiescent state during normal tissue turnover, but are activated in response to injury through the microenvironment and cell-intrinsic signals. During aging, SC dysfunction is a major contributor to the decline in regenerative potential of muscle tissue. Recent studies have demonstrated that both cell-intrinsic and cell-extrinsic factors are deregulated during aging...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29303112/biomimetic-hydrogels-direct-spinal-progenitor-cell-differentiation-and-promote-functional-recovery-after-spinal-cord-injury
#20
Sydney A Geissler, Alexandra L Sabin, Rachel R Besser, Olivia M Gooden, Bryce D Shirk, Quan M Nguyen, Zin Z Khaing, Christine E Schmidt
Demyelination that results from disease or traumatic injury, such as spinal cord injury (SCI), can have a devastating effect on neural function and recovery. Many researchers are examining treatments to minimize demyelination by improving oligodendrocyte availability in vivo. Transplantation of stem and oligodendrocyte progenitor cells is a promising option, however, trials are plagued by undirected differentiation [1]. Here we introduce a biomaterial that has been optimized to direct the differentiation of neural progenitor cells (NPCs) toward oligodendrocytes as a cell delivery vehicle after SCI...
January 5, 2018: Journal of Neural Engineering
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