keyword
https://read.qxmd.com/read/37982462/epstein-barr-virus-associated-lymphomatoid-papules-a-sign-of-immunosuppression-resembling-lymphomatoid-papulosis
#1
JOURNAL ARTICLE
Madeline J Hooper, Woo Jin Lee, Tessa M LeWitt, Cuong Nguyen, Teresa Griffin, Christopher Chung, Xiaolong A Zhou, Joan Guitart
Epstein-Barr virus (EBV)-positive lymphoproliferative disorders associated with immunodeficiency constitute a spectrum of lymphoid and plasma cell proliferations that vary in cytomorphology, immunophenotype, and clinical behavior. CD30-positive cutaneous lymphocytic infiltrates with EBV expression and lymphomatoid papulosis-like presentations have been rarely reported. This retrospective study assessed the clinical and histopathological characteristics of EBV-positive cases with papulonodular morphologies and CD30 positivity seen by Northwestern Medicine Dermatopathology...
December 1, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/37802757/primary-cutaneous-t-cell-lymphoma-a-review-of-the-most-common-entities-with-focus-on-recent-updates
#2
REVIEW
Jasmine S Saleh, Antonio Subtil, Alexandra C Hristov
Cutaneous T-cell lymphomas are an heterogeneous group of uncommon lymphoid neoplasms that are challenging to diagnose and require close collaboration between dermatologists, pathologists and hematologists/oncologists. This article reviews the most common cutaneous T-cell lymphomas: mycosis fungoides (both classic and variant forms) as well as its leukemic counterpart Sézary syndrome, CD30+ T-cell lymphoproliferative disorders including the ever-expanding group of lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma, and primary cutaneous CD4+ small/medium lymphoproliferative disorder...
October 2023: Human Pathology
https://read.qxmd.com/read/37539944/prognostic-factors-for-primary-cutaneous-anaplastic-large-cell-lymphoma-a-multicenter-retrospective-study-from-japan
#3
JOURNAL ARTICLE
Tomomitsu Miyagaki, Norihito Inoue, Hiroaki Kamijo, Hikari Boki, Naomi Takahashi-Shishido, Hiraku Suga, Takatoshi Shimauchi, Eiji Kiyohara, Yoji Hirai, Kentaro Yonekura, Kengo Takeuchi, Makoto Sugaya
BACKGROUND: Clinical implications of DUSP22 rearrangement and the association between DUSP22 rearrangement and lymphoid enhancer-binding factor 1 (LEF1) expression pattern in CD30-positive cutaneous T-cell lymphomas (CTCLs) are unknown. OBJECTIVES: This study assessed the incidence of DUSP22 rearrangement and its clinical and immunohistochemical implications in primary cutaneous anaplastic large cell lymphoma (pcALCL), lymphomatoid papulosis (LyP), and CD30-positive mycosis fungoides (MF) with large cell transformation (MF-LCT), especially focusing on the association with the prognosis and LEF1 expression pattern...
August 4, 2023: British Journal of Dermatology
https://read.qxmd.com/read/37307932/primary-cutaneous-t-cell-lymphoma-a-review-of-the-most-common-entities-with-focus-on-recent-updates
#4
JOURNAL ARTICLE
Jasmine S Saleh, Antonio Subtil, Alexandra C Hristov
Cutaneous T-cell lymphomas are an heterogeneous group of uncommon lymphoid neoplasms that are challenging to diagnose and require close collaboration between dermatologists, pathologists and hematologists/oncologists. This article reviews the most common cutaneous T-cell lymphomas: mycosis fungoides (both classic and variant forms) as well as its leukemic counterpart Sézary syndrome, CD30+ T-cell lymphoproliferative disorders including the ever-expanding group of lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma, and primary cutaneous CD4+ small/medium lymphoproliferative disorder...
June 10, 2023: Human Pathology
https://read.qxmd.com/read/37248740/lymphomatoid-papulosis-associated-with-myeloid-neoplasm-with-eosinophilia-and-fip1l1-pdgfra-rearrangement-successful-imatinib-treatment-in-two-cases
#5
JOURNAL ARTICLE
Valentina Bellani, Giorgio Alberto Croci, Cristina Bucelli, Carlo Alberto Maronese, Sara Alberti, Alessandra Iurlo, Daniele Cattaneo
Lymphomatoid papulosis (LyP) is a benign condition, listed among primary cutaneous CD30+ lymphoproliferative disorders. Its typical picture consists of relapsing-remitting papular lesions and it can be encountered in the course of a hematologic disease, at times representing its first manifestation. Hypereosinophilic syndromes are a heterogeneous group of disorders characterized by persistent peripheral blood hypereosinophilia that may lead to life-threatening organ damage. Among eosinophilic disorders, the subtype identified as myeloid/lymphoid neoplasm with eosinophilia and tyrosine kinase gene fusions has aroused particular interest due to its excellent response to tyrosine kinase inhibitors, including imatinib...
May 30, 2023: Journal of Dermatology
https://read.qxmd.com/read/36307824/type-d-lymphomatoid-papulosis-with-pityriasis-lichenoides-et-varioliformis-acuta-like-features-in-a-child-with-parvovirus-infection-a-controversial-diagnosis-in-the-spectrum-of-lymphoid-proliferations-case-report-and-literature-review
#6
JOURNAL ARTICLE
Valeria Calcaterra, Riccardo Cavalli, Giorgio A Croci, Laura Fiori, Antonella Fabiano, Luisa Lunardon, Maria Antonietta Avanzini, Emilio Berti, Gianvincenzo Zuccotti
BACKGROUND: Lymphomatoid papulosis (LyP) is a rare condition in pediatrics; LyP histological type D has been reported in only 7 children. The differential diagnosis of LyP in the spectrum of lymphoid proliferation remains controversial. CASE PRESENTATION: A 6-year-old boy presented to Emergency Department with a 3-week history of an erythematous papulo-vesicular itchy eruption over the submandibular regions, trunk and extremities. History, symptoms and laboratory tests were unremarkable...
October 28, 2022: Italian Journal of Pediatrics
https://read.qxmd.com/read/34568060/case-report-contrasting-bcl2-upregulation-with-venetoclax-in-a-case-of-refractory-lymphomatoid-papulosis-and-progressive-chronic-lymphocytic-leukemia
#7
Valerio Guarente, Giovanni Martino, Erica Dorillo, Filomena De Falco, Chiara Rompietti, Daniele Sorcini, Mariangela Brogna, Valeria Cardinali, Stefano Ascani, Andrea Marra, Paolo Sportoletti
A 57-year-old man affected by high-risk progressive chronic lymphocytic leukemia (CLL), primary resistant to first-line chemoimmunotherapy, developed a type A lymphomatoid papulosis (LyP) during a second progression of CLL. The two blood tumor entities were clonally unrelated. LyP presented with a diffuse (>90% body surface area) cutaneous rash and was characterized by intensely pruriginous dusky nodules (n = 10) and red flat-topped papules (n = 60). No response to topical corticosteroids and psoralen plus ultraviolet A (PUVA) phototherapy was observed...
2021: Frontiers in Oncology
https://read.qxmd.com/read/31930561/pediatric-cellular-neurothekeoma-seven-cases-and-systematic-review-of-the-literature
#8
JOURNAL ARTICLE
Morgan Murphrey, Austin Huy Nguyen, Kevin P White, Alfons Krol, Richard Bernert, Kevin Yarbrough
BACKGROUND/OBJECTIVES: Neurothekeoma is a rare, benign, cutaneous neoplasm consisting of Schwann cells and perineural cells in myxoid stroma. Cellular neurothekeoma (CNT) was previously thought to represent a morphologic variant of neurothekeoma, but recent studies have shown that CNTs are unrelated to neurothekeomas and are more likely of histiocytic lineage. METHODS: Herein, we describe seven cases of CNT in pediatric patients. A comprehensive search of PubMed was performed, and 71 cases of cellular neurothekeoma in pediatric patients were reviewed...
January 12, 2020: Pediatric Dermatology
https://read.qxmd.com/read/31577659/does-breast-implant-associated-alcl-begin-as-a-lymphoproliferative-disorder
#9
JOURNAL ARTICLE
Marshall E Kadin, William P Adams, Giorgio Inghirami, Arianna Di Napoli
Breast implant associated anaplastic large cell lymphoma (BIA-ALCL) has been included as a provisional entity in the revised version of the WHO Classification of Tumors of Haematopoietic and Lymphoid Tissue. To increase opportunities to intervene with early diagnosis, treatment and possible prevention, it is important to consider that BIA-ALCL may evolve from a pre-existing lymphoproliferative disorder (LPD) characterized by (1) an indolent localized (in situ) disease in about 80% of reported cases; (2) a requirement for external cytokine stimulation for cell survival; (3) CD30+ cells in some clinically benign seromas/capsules; (4) undetected T-cell clonality in some cases; (5) JAK/STAT mutations in only a minority of cases (6) cure by capsulectomy and implant removal in most cases...
September 30, 2019: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/31542070/lymphomatoid-papulosis-type-b-in-a-patient-with-crohn-s-disease-treated-with-tnf-alpha-inhibitors-infliximab-and-adalimumab
#10
JOURNAL ARTICLE
Márta Medvecz, Norbert Kiss, Judit Hársing, Enikő Kuroli, Gábor Hegede, Judit Csomor, Sarolta Kárpáti, Márta Marschalkó
Dear Editor, Lymphomatoid papulosis (LP) is a chronic, recurrent, usually self-limited papulonecrotic or papulonodular skin disease, which belongs to the group of primary cutaneous CD30+ lymphoproliferative disorders (1). Three main histological subtypes of LP have been recognized: type A (histiocytic), type B (mycosis fungoides-like), and type C (anaplastic large cell lymphoma-like). Recently, new histologic LP variants classified as type D (CD8-positive, cytotoxic form) and type E (angioinvasive form) have also been described...
September 2019: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/28937425/a-case-of-lymphomatoid-papulosis-type-e-with-an-unusual-exacerbated-clinical-course
#11
JOURNAL ARTICLE
Irena E Belousova, Liubov Kyrpychova, Alexey V Samtsov, Dmitry V Kazakov
Lymphomatoid papulosis (LyP) type E is a recently delineated variant characterized by the occurrence of large necrotic "eschar"-like lesions displaying microscopically angioinvasive and angiodestructive infiltrates composed of CD30 lymphocytes, frequently coexpressing CD8. In contrast to other LyP variants where patients develop multiple lesions, most patients with LyP type E present with few lesions (often 1 or 2 at a given time). In this article, we describe a 34-year-old man with LyP type E with an exacerbated clinical course characterized by the occurrence of almost a hundred of lesions...
February 2018: American Journal of Dermatopathology
https://read.qxmd.com/read/27598618/linear-ectopic-sebaceous-hyperplasia-of-the-penis-the-last-memory-of-tyson-s-glands
#12
JOURNAL ARTICLE
Giovanni Paolino, Luca M Muscardin, Chiara Panetta, Michele Donati, Pietro Donati
Pathologists who find ectopic glands on the glans and/or on the prepuce, often describe them as Tyson's glands. In this regard, the term Tyson's glands can be replaced by two different descriptive expressions: papillomatosis corona penis and ectopic sebaceous glands. A 15-year-old Caucasian male patient presented to our Institute with multiple and asymptomatic circular skin colored-to-yellowish papules at the level of the foreskin, also affecting the shaft of the penis, where they assumed a linear feature. The histological examination revealed hyperplastic and dilated sebaceous glands, while in some areas these glands showed also a direct attachment with the epidermis...
June 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://read.qxmd.com/read/26288406/primary-cutaneous-cd8-cd30-anaplastic-large-cell-lymphoma-an-unusual-case-with-a-high-ki-67-index-a-short-review
#13
JOURNAL ARTICLE
Jitendra G Nasit, Smita C Patel
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a part of the spectrum of CD30(+) cutaneous lymphoproliferative disorder, characterized by variable degrees of CD2, CD3, CD4 and CD5 expression by lymphoid cells. PCALCLs with an expression of cytotoxic phenotype (CD8(+)) and cytotoxic proteins are uncommon. Cutaneous CD8(+) CD30(+) lymphoproliferative lesions are difficult to classify, diagnose and may be the cause of misdiagnose. CD8(+) PCALCL must be distinguished from CD8(+) mycosis fungoides, lymphomatoid papulosis type D and primary cutaneous aggressive epidermotropic CD8(+) T-cell lymphoma...
July 2015: Indian Journal of Dermatology
https://read.qxmd.com/read/26268415/evaluation-of-the-2008-world-health-organization-classification-for-non-mycosis-fungoides-non-sezary-syndrome-t-nk-cell-lymphomas-with-primary-cutaneous-involvement
#14
JOURNAL ARTICLE
Daniel Chang, Maria Cláudia Nogueira Zerbini, Mirian Nacagami Sotto, Sheila Aparecida Coelho Siqueira, José Antonio Sanches
BACKGROUND: Cutaneous non-mycosis fungoides non-Sezary syndrome T/NK cell lymphomas (non-MF/non-SS CTCL) are rare. In 2005, a consensus of the World Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classifications for primary cutaneous lymphomas was established. These guidelines were then adopted into the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 2008. This study aims to assess the applicability of the WHO 2008 classification in a retrospective series of CTCL cases registered in a reference academic center in Brazil...
December 2015: Journal of Cutaneous Pathology
https://read.qxmd.com/read/25382820/a-unique-case-of-concurrent-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-and-lymphomatoid-papulosis-in-the-same-biopsy
#15
JOURNAL ARTICLE
J Hibler, Andrea L Salavaggione, Ann Martin, Alejandro A Gru
Chronic lymphocytic leukemia (CLL/SLL) is the most common leukemia in the western world and its cutaneous dissemination a very uncommon phenomenon. Lymphomatoid papulosis (LyP) is a CD30+ lymphoproliferative disorder characterized by chronic, recurrent and self healing skin lesions. Up to 20% of patients with LyP have a coexistent lymphoma. While the association between the two entities has been reported, their coexistence has never been documented. We describe a 74-year-old man with known CLL and thrombocytopenia who presented with a 2 year history of recurrent nodules and plaques to both arms and legs that resolved within 4-6 weeks after administration of rituximab and bendamustin for his CLL treatment...
April 2015: Journal of Cutaneous Pathology
https://read.qxmd.com/read/24911471/lymphomatoid-papulosis-type-c-of-the-eyelid-in-a-young-girl-a-case-report-and-review-of-literature
#16
REVIEW
Manju Meena, Peter A Martin, Claire Abouseif, Peter Bullpitt
PURPOSE: To report an unusual presentation of a case of Lymphomatoid papulosis(LyP) in a young girl. MATERIAL AND METHODS: A 14-year-old female presented with a history of swelling of the left upper eyelid of two weeks duration. There was a history of trivial trauma prior to the swelling. The patient was diagnosed as having pre-septal cellulitis elsewhere and was put on oral antibiotics. The lesion was non-responsive to oral antibiotics. The patient was then referred to our hospital...
October 2014: Orbit
https://read.qxmd.com/read/22688398/lymphomatoid-papulosis-type-d-a-newly-described-variant-easily-confused-with-cutaneous-aggressive-cd8-positive-cytotoxic-t-cell-lymphoma
#17
JOURNAL ARTICLE
Jose Cardoso, Parmjit Duhra, Yi Thway, Eduardo Calonje
Lymphomatoid papulosis (LyP) is defined as a chronic recurrent skin disease characterized by waxing and waning papules and nodules with histologic features of a CD30-positive T-cell lymphoma. Three histological subtypes (A, B, and C) were already recognized, and only more recently, a further variant simulating histologically an aggressive epidermotropic CD8-positive T-cell lymphoma was described, which was named LyP type D by the authors. We report the case of a 38-year-old woman presenting with a 1-year history of recurrent self-healing papules and nodules, predominantly affecting her upper and lower limbs but also the face, including the lower lip, with no associated systemic symptoms...
October 2012: American Journal of Dermatopathology
https://read.qxmd.com/read/21542963/clinical-and-prognostic-characteristics-of-pulmonary-mucosa-associated-lymphoid-tissue-lymphoma-a-retrospective-analysis-of-23-cases-in-a-chinese-population
#18
JOURNAL ARTICLE
Hui Huang, Zhi-Wei Lu, Chun-Guo Jiang, Ji Li, Kai Xu, Zuo-Jun Xu
BACKGROUND: Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is the most frequent type of non-Hodgkin's lymphoma (NHL) that primarily involves the lungs. It represents a rare entity accounting for less than 1% of all NHLs and the clinical features have yet to be clearly elucidated. METHODS: The clinicopathological features and radiological data of 23 patients with pulmonary MALT lymphoma confirmed by biopsy in Peking Union Medical College Hospital from January 2001 to December 2010 were retrospectively analyzed...
April 2011: Chinese Medical Journal
https://read.qxmd.com/read/20669794/primary-cutaneous-and-systemic-anaplastic-large-cell-lymphoma-clinicopathologic-aspects-and-therapeutic-options
#19
REVIEW
Christiane Querfeld, Irum Khan, Brett Mahon, Beverly P Nelson, Steven T Rosen, Andrew M Evens
Anaplastic large cell lymphoma (ALCL) is a biologic and clinically heterogenous subtype of T-cell lymphoma. Clinically, ALCL may present as localized (primary) cutaneous disease or widespread systemic disease. These two forms of ALCL are distinct entities with different clinical and biologic features. Both types share similar histology, however, with cohesive sheets of large lymphoid cells expressing the Ki-1 (CD30) molecule. Primary cutaneous ALCL (C-ALCL) is part of the spectrum of CD30+ lymphoproliferative diseases of the skin including lymphomatoid papulosis...
June 2010: Oncology (Williston Park, NY)
https://read.qxmd.com/read/19969358/spectrum-of-cd30-lymphoid-proliferations-in-the-eyelid-lymphomatoid-papulosis-cutaneous-anaplastic-large-cell-lymphoma-and-anaplastic-large-cell-lymphoma
#20
JOURNAL ARTICLE
R Krishna Sanka, Ralph C Eagle, Ted H Wojno, Kenneth R Neufeld, Hans E Grossniklaus
PURPOSE: To report the clinicopathologic features of 3 patients with CD30(+) lymphoid proliferations of the eyelid. DESIGN: Retrospective case series. PARTICIPANTS: Patients with cutaneous CD30(+) lymphoproliferative lesions of the eyelid. METHODS: Three patients with CD30(+) non-mycosis fungoides T-cell lymphoid infiltrates of the eyelid were identified. The histories, clinical findings, pathologic features including immunohistochemical staining, treatments, and outcomes were reviewed and compared...
February 2010: Ophthalmology
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