keyword
https://read.qxmd.com/read/38536541/bone-marrow-mesenchymal-stem-cell-derived-exosomes-promote-the-recovery-of-spinal-cord-injury-and-inhibit-ferroptosis-by-inactivating-il-17-pathway
#1
JOURNAL ARTICLE
Wen Tang, Kai Zhao, Xiaobo Li, Xiaozhong Zhou, Peigen Liao
Mesenchymal stem cell (MSC)-derived exosomes are considered as alternative to cell therapy in various diseases. This study aimed to understand the effect of bone marrow MSC-derived exosomes (BMMSC-exos) on spinal cord injury (SCI) and to unveil its regulatory mechanism on ferroptosis. Exosomes were isolated from BMMSCs and the uptake of BMMSCs-exos by PC12 cells was determined using PKH67 staining. The effect of BMMSC-exos on SCI in rats was studied by evaluating pathological changes of spinal cord tissues, inflammatory cytokines, and ferroptosis-related proteins...
March 27, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38535706/static-magnetic-field-enhances-the-bone-remodelling-capacity-of-human-demineralized-bone-matrix-in-a-rat-animal-model-of-cranial-bone-defects
#2
JOURNAL ARTICLE
SeyedJamal Hosseini, Houman Parsaei, MirJavad Moosavifar, Narjes Tavakoli, Reza Ahadi, Kaveh Roshanbinfar
The regeneration of bone defects that exceed 2 cm is a challenge for the human body, necessitating interventional therapies. Demineralized bone matrices (DBM) derived from biological tissues have been employed for bone regeneration and possess notable osteoinductive and osteoconductive characteristics. Nevertheless, their efficiency in regenerating critically sized injuries is limited, and therefore additional signaling cues are required. Thanks to the piezoelectric properties of the bone, external physical stimulation is shown to accelerate tissue healing...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38534563/unlocking-the-potential-of-stem-cell-microenvironments-in-vitro
#3
REVIEW
Chiara Scodellaro, Raquel R Pina, Frederico Castelo Ferreira, Paola Sanjuan-Alberte, Tiago G Fernandes
The field of regenerative medicine has recently witnessed groundbreaking advancements that hold immense promise for treating a wide range of diseases and injuries. At the forefront of this revolutionary progress are stem cells. Stem cells typically reside in specialized environments in vivo, known as microenvironments or niches, which play critical roles in regulating stem cell behavior and determining their fate. Therefore, understanding the complex microenvironments that surround stem cells is crucial for advancing treatment options in regenerative medicine and tissue engineering applications...
March 19, 2024: Bioengineering
https://read.qxmd.com/read/38534363/neonatal-brains-exhibit-higher-neural-reparative-activities-than-adult-brains-in-a-mouse-model-of-ischemic-stroke
#4
JOURNAL ARTICLE
Ryo Nishiyama, Takayuki Nakagomi, Akiko Nakano-Doi, Yoji Kuramoto, Masahiro Tsuji, Shinichi Yoshimura
The neonatal brain is substantially more resistant to various forms of injury than the mature brain. For instance, the prognosis following ischemic stroke is generally poor in the elderly but favorable in neonates. Identifying the cellular and molecular mechanisms underlying reparative activities in the neonatal brain after ischemic injury may provide feasible targets for therapeutic interventions in adults. To this end, we compared the reparative activities in postnatal day 13 and adult (8-12-week-old) mouse brain following middle cerebral artery occlusion...
March 15, 2024: Cells
https://read.qxmd.com/read/38534355/recent-research-trends-in-neuroinflammatory-and-neurodegenerative-disorders
#5
REVIEW
Jessica Cohen, Annette Mathew, Kirk D Dourvetakis, Estella Sanchez-Guerrero, Rajendra P Pangeni, Narasimman Gurusamy, Kristina K Aenlle, Geeta Ravindran, Assma Twahir, Dylan Isler, Sara Rukmini Sosa-Garcia, Axel Llizo, Alison C Bested, Theoharis C Theoharides, Nancy G Klimas, Duraisamy Kempuraj
Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions of these disease pathogeneses is currently not clearly understood. These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of peripheral immune cells into the brain, as well as entry of inflammatory mediators through damaged neurovascular endothelial cells, blood-brain barrier and tight junction proteins...
March 14, 2024: Cells
https://read.qxmd.com/read/38529506/senolytic-car-t-cells-reverse-aging-associated-defects-in-intestinal-regeneration-and-fitness
#6
Onur Eskiocak, Saria Chowdhury, Vyom Shah, Emmanuella Nnuji-John, Charlie Chung, Jacob A Boyer, Alexander S Harris, Jill Habel, Michel Sadelain, Semir Beyaz, Corina Amor
Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium to maintain organismal homeostasis. Aging, however, significantly reduces intestinal regenerative capacity. While cellular senescence is a key feature of the aging process, little is known about the in vivo effects of senescent cells on intestinal fitness. Here, we identify the accumulation of senescent cells in the aging gut and, by harnessing senolytic CAR T cells to eliminate them, we uncover their detrimental impact on epithelial integrity and overall intestinal homeostasis in natural aging, injury and colitis...
March 22, 2024: bioRxiv
https://read.qxmd.com/read/38529490/an-injury-induced-tissue-niche-shaped-by-mesenchymal-plasticity-coordinates-the-regenerative-and-disease-response-in-the-lung
#7
Dakota L Jones, Michael P Morley, Xinyuan Li, Yun Ying, Fabian L Cardenas-Diaz, Shanru Li, Su Zhou, Sarah E Schaefer, Ullas V Chembazhi, Ana Nottingham, Susan Lin, Edward Cantu, Joshua M Diamond, Maria C Basil, Andrew E Vaughan, Edward E Morrisey
Severe lung injury causes basal stem cells to migrate and outcompete alveolar stem cells resulting in dysplastic repair and a loss of gas exchange function. This "stem cell collision" is part of a multistep process that is now revealed to generate an i njury-induced t issue ni ch e (iTCH) containing Keratin 5+ epithelial cells and plastic Pdgfra+ mesenchymal cells. Temporal and spatial single cell analysis reveals that iTCHs are governed by mesenchymal proliferation and Notch signaling, which suppresses Wnt and Fgf signaling in iTCHs...
February 29, 2024: bioRxiv
https://read.qxmd.com/read/38528832/role-of-dendritic-cells-in-spinal-cord-injury
#8
REVIEW
Xiaonan Han, Mingkang Zhang, Liyan Yan, Yikun Fu, Hongwei Kou, Chunfeng Shang, Junmin Wang, Hongjian Liu, Chao Jiang, Jian Wang, Tian Cheng
BACKGROUND: Inflammation can worsen spinal cord injury (SCI), with dendritic cells (DCs) playing a crucial role in the inflammatory response. They mediate T lymphocyte differentiation, activate microglia, and release cytokines like NT-3. Moreover, DCs can promote neural stem cell survival and guide them toward neuron differentiation, positively impacting SCI outcomes. OBJECTIVE: This review aims to summarize the role of DCs in SCI-related inflammation and identify potential therapeutic targets for treating SCI...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38525980/ocular-chemical-injuries-and-limbal-stem-cell-deficiency-lscd-an-update-on-management
#9
JOURNAL ARTICLE
Yandong Bian, Ula Jurkunas
No abstract text is available yet for this article.
April 1, 2024: International Ophthalmology Clinics
https://read.qxmd.com/read/38525780/isolation-and-culture-of-primary-human-dental-pulp-cells-a-description-of-technical-and-methodological-steps-to-maximise-predictability-and-yield
#10
JOURNAL ARTICLE
Michaela Kearney, David E McReynolds, Henry F Duncan
The dental pulp has critical functions in tooth development as well as an ongoing role in promoting and maintaining the vitality of teeth. In particular, its regenerative ability allows dental tissues to be restored following damage caused by traumatic injury or caries. Regenerative endodontic procedures aim to utilise these processes to stimulate dental pulp repair in a minimally invasive manner and reduce the need for more invasive procedures such as root canal treatment. Dental pulp is a source of dental pulp cells (DPCs), which has a subpopulation of dental pulp stem cells (DPSCs), which are attractive for use in regenerative medicine due to their high proliferation rate, ability to differentiate into multiple cell types, and their preserved vitality following cryopreservation...
March 1, 2024: Methods and Protocols
https://read.qxmd.com/read/38523796/mild-hypothermia-promotes-neuronal-differentiation-of-human-neural-stem-cells-via-rbm3-sox11-signaling-pathway
#11
JOURNAL ARTICLE
Yuxiao Ma, Zhenghui He, Jiangchang Wang, Ping Zheng, Zixuan Ma, Qian Liang, Qiao Zhang, Xiongfei Zhao, Jialin Huang, Weiji Weng, Jiyao Jiang, Junfeng Feng
Both therapeutic hypothermia and neural stem cells (NSCs) transplantation have shown promise in neuroprotection and neural repair after brain injury. However, the effects of therapeutic hypothermia on neuronal differentiation of NSCs are not elucidated. In this study, we aimed to investigate whether mild hypothermia promoted neuronal differentiation in cultured and transplanted human NSCs (hNSCs). A significant increase in neuronal differentiation rate of hNSCs was found when exposed to 35°C, from 33% to 45% in vitro and from 7% to 15% in vivo ...
April 19, 2024: IScience
https://read.qxmd.com/read/38523616/mapping-knowledge-of-the-stem-cell-in-traumatic-brain-injury-a-bibliometric-and-visualized-analysis
#12
JOURNAL ARTICLE
Tingzhen Deng, Ruiwen Ding, Yatao Wang, Yueyang Chen, Hongtao Sun, Maohua Zheng
BACKGROUND: Traumatic brain injury (TBI) is a brain function injury caused by external mechanical injury. Primary and secondary injuries cause neurological deficits that mature brain tissue cannot repair itself. Stem cells can self-renewal and differentiate, the research of stem cells in the pathogenesis and treatment of TBI has made significant progress in recent years. However, numerous articles must be summarized to analyze hot spots and predict trends. This study aims to provide a panorama of knowledge and research hotspots through bibliometrics...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38522706/poly-l-lactic-acid-gelatin-electrospun-membrane-loaded-bone-marrow-derived-mesenchymal-stem-cells-attenuate-erectile-dysfunction-caused-by-cavernous-nerve-injury
#13
JOURNAL ARTICLE
Daoyuan Hu, Chang Liu, Yunlong Ge, Lei Ye, Qiang Guo, Yuhang Xi, Wenliang Zhu, Dejuan Wang, Tao Xu, Jianguang Qiu
Radical prostatectomy (RP) can cause neurogenic erectile dysfunction (ED), which negatively affects the quality of life of patients with prostate cancer. Currently, there is a dearth of effective therapeutic strategies. Although stem cell therapy is promising, direct cell transplantation to injured cavernous nerves is constrained by poor cell colonization. In this study, poly-L-lactic acid (PLLA)/gelatin electrospun membranes (PGEM) were fabricated to load bone marrow-derived mesenchymal stem cells (BM-MSCs) as a patch to be placed on injured nerves to alleviate ED...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38522633/generation-of-induced-pluripotent-stem-cells-from-rat-fibroblasts-and-optimization-of-its-differentiation-into-mature-functional-neurons
#14
JOURNAL ARTICLE
Ram Kuwar, Ning Zhang, Adam McQuiston, Xuejun Wen, Dong Sun
BACKGROUND: Induced pluripotent stem cells (iPSCs) derived neural stem cells (NSCs) provide a potential for autologous neural transplantation therapy following neurological insults. Thus far, in preclinical studies the donor iPSCs-NSCs are mostly of human or mouse origin with concerns centering around graft rejection when applied to rat brain injury models. For better survival and integration of transplanted cells in the injured brain in rat models, use of rat-iPSC-NSCs and in combination with biomaterials is of advantageous...
March 22, 2024: Journal of Neuroscience Methods
https://read.qxmd.com/read/38520720/significant-impact-of-antibiotic-exposure-on-gi-gvhd-nrm-and-grfs-following-allogeneic-hct-with-non-myeloablative-flu-tbi-conditioning
#15
JOURNAL ARTICLE
Lenneke F J van Groningen, Suzanne van Dorp, Manita E J Bremmers, Shahira Fazel, Mieke W H Roeven, Nicole M A Blijlevens, Walter J F M van der Velden
BACKGROUND: Acute gastro-intestinal graft- versus -host disease (GI-GVHD) and non-relapse mortality (NRM) after allogeneic HCT are closely related to loss of microbial diversity and intestinal dominance by single taxa resulting from the use of antibiotics, dietary changes, and mucosal barrier injury. There is a paucity of data on the impact of use of antibiotics in HCT after Flu-TBI-based non-myeloablative (NMA) conditioning where there is absence of mucositis and limited malnutrition...
March 23, 2024: Leukemia & Lymphoma
https://read.qxmd.com/read/38520608/research-advances-in-stem-cell-therapy-for-erectile-dysfunction
#16
REVIEW
Wei Wang, Ying Liu, Zuo-Bin Zhu, Kun Pang, Jing-Kai Wang, Jun Gu, Zhen-Bei Li, Jian Wang, Zhen-Duo Shi, Cong-Hui Han
Erectile dysfunction (ED) is a common clinical condition that mainly affects men aged over 40 years. Various causes contribute to the progression of ED, including pelvic nerve injury, diabetes, metabolic syndrome, age, Peyronie's disease, smoking, and psychological disorders. Current treatments for ED are limited to symptom relief and do not address the root cause. Stem cells, with their powerful ability to proliferate and differentiate, are a promising approach for the treatment of male ED and are gradually gaining widespread attention...
March 23, 2024: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://read.qxmd.com/read/38519640/genetic-contribution-to-microglial-activation-in-schizophrenia
#17
JOURNAL ARTICLE
Marja Koskuvi, Elina Pörsti, Tristen Hewitt, Noora Räsänen, Ying-Chieh Wu, Kalevi Trontti, Amanda McQuade, Shringaa Kalyanaraman, Ilkka Ojansuu, Olli Vaurio, Tyrone D Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta, Markku Lähteenvuo, Taisia Rolova, Šárka Lehtonen, Jari Tiihonen, Jari Koistinaho
Several lines of evidence indicate the involvement of neuroinflammatory processes in the pathophysiology of schizophrenia (SCZ). Microglia are brain resident immune cells responding toward invading pathogens and injury-related products, and additionally, have a critical role in improving neurogenesis and synaptic functions. Aberrant activation of microglia in SCZ is one of the leading hypotheses for disease pathogenesis, but due to the lack of proper human cell models, the role of microglia in SCZ is not well studied...
March 22, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38519518/intrinsic-and-extrinsic-actions-of-human-neural-progenitors-with-sufu-inhibition-promote-tissue-repair-and-functional-recovery-from-severe-spinal-cord-injury
#18
JOURNAL ARTICLE
Yong-Long Chen, Xiang-Lan Feng, Kin-Wai Tam, Chao-Yang Fan, May Pui-Lai Cheung, Yong-Ting Yang, Stanley Wong, Daisy Kwok-Yan Shum, Ying-Shing Chan, Chi-Wai Cheung, Martin Cheung, Jessica Aijia Liu
Neural progenitor cells (NPCs) derived from human pluripotent stem cells(hPSCs) provide major cell sources for repairing damaged neural circuitry and enabling axonal regeneration after spinal cord injury (SCI). However, the injury niche and inadequate intrinsic factors in the adult spinal cord restrict the therapeutic potential of transplanted NPCs. The Sonic Hedgehog protein (Shh) has crucial roles in neurodevelopment by promoting the formation of motorneurons and oligodendrocytes as well as its recently described neuroprotective features in response to the injury, indicating its essential role in neural homeostasis and tissue repair...
March 22, 2024: NPJ Regenerative Medicine
https://read.qxmd.com/read/38519036/intranasal-delivery-of-small-extracellular-vesicles-from-specific-subpopulation-of-mesenchymal-stem-cells-mitigates-traumatic-spinal-cord-injury
#19
JOURNAL ARTICLE
Yi Sun, Jinyun Zhao, Quanbo Liu, Yan Xu, Yiming Qin, Rundong He, Lifu Zheng, Yong Xie, Chengjun Li, Tianding Wu, Yong Cao, Chunyue Duan, Hongbin Lu, Jianzhong Hu
Vascular injury following spinal cord injury (SCI) can significantly exacerbate secondary SCI and result in neurological dysfunction. Strategies targeting angiogenesis have demonstrated potential in enhancing functional recovery post-SCI. In the context of angiogenesis, the CD146+ and CD271+ subpopulations of mesenchymal stem cells (MSCs) have been recognized for their angiogenic capabilities in tissue repair. Small extracellular vesicles (sEVs) derived from MSCs are nanoscale vesicles containing rich bioactive components that play a crucial role in tissue regeneration...
March 20, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38518900/mesenchymal-stem-cell-derived-exosomes-promote-tissue-repair-injury-in-rats-with-liver-trauma-by-regulating-gut-microbiota-and-metabolism
#20
JOURNAL ARTICLE
Bo Yi, Juan Pan, Zhaoming Yang, Zemin Zhu, Yongkang Sun, Tao Guo, Zhijian Zhao
OBJECTIVE: The effects of mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-exos) on serum metabolites and intestinal microbiota in rats after liver trauma were discussed. METHODS: Adult Wistar Albino rats were assigned into control, model (liver trauma), MSCs, and MSC-exos groups (n = 6). The study examined changes in the inflammatory environment in liver tissues were analyzed by histological examination and analysis of macrophage phenotypes...
March 20, 2024: Molecular and Cellular Probes
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