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Concussion, mild traumatic brain injury

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https://www.readbyqxmd.com/read/29446796/posttraumatic-headache
#1
Raquel Langdon, Sharief Taraman
After sustaining a concussion or mild traumatic brain injury, headaches are one of the most common complaints. The pathophysiologic changes that occur in the setting of injury likely contribute to or cause posttraumatic headaches. Posttraumatic headaches often present as migraine or tension-type headaches. Unlike pain from other types of injuries, headaches following mild traumatic brain injury are more likely to persist. Preexisting conditions such as migraine and mood disorders may influence posttraumatic headache and complicate management...
February 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29446658/post-concussive-symptoms-after-a-mild-traumatic-brain-injury-during-childhood-and-adolescence
#2
Nicola J Starkey, Kelly Jones, Rosalind Case, Alice Theadom, Suzanne Barker-Collo, Valery Feigin
OBJECTIVE: Mild traumatic brain injury (mTBI) is common injury during childhood and adolescence but the long-term outcomes are poorly understood. This study examined post-concussive symptoms and behavioural outcomes in children and adolescents up to 24 months post-mTBI. METHOD: Parents of children aged 8-15 years with mTBI completed the BASC-2 and Rivermead Post-Concussion Symptoms Questionnaire at baseline, 1-, 6-, 12- and 24 months post-injury. An age-matched traumatic brain injury-free cohort was recruited and assessed at 12- and 24 months...
February 15, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29432249/pediatric-traumatic-brain-injury-and-concussion
#3
Meeryo Choe, Karen M Barlow
PURPOSE OF REVIEW: This article summarizes the impact and complications of mild traumatic brain injury and concussion in children and outlines the recent evidence for its assessment and early management. Useful evidence-based management strategies are provided for children who have a typical recovery following concussion as well as for those who have persistent postconcussion syndrome. Cases are used to demonstrate the commonly encountered pathologies of headache, cognitive issues, and mood disturbances following injury...
February 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29430327/-mild-head-injury
#4
José Manuel Ortega Zufiría, Noemí Lomillos Prieto, Bernardino Choque Cuba, Martin Tamarit Degenhardt, Pedro Poveda Núñez, María Remedios López Serrano, Azahara Belén López Raigada
Introduction: Mild traumatic brain injury (TBI) represents a major health concern, because a sizeable number of patients with mild TBI will develop potentially life-threatening complications. The target of this study was to describe a large series of adult patients suffering from mild TBI, treated at University Hospital of Getafe, between 2010 and 2015 (n = 2480). We examined the patients' epidemiological and baseline clinical profile, diagnosis, treatment and ultimate outcomes, to identify major prognostic factors that influence the final result...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29393686/reliability-of-the-balance-error-scoring-system-in-a-population-with-protracted-recovery-from-mild-traumatic-brain-injury
#5
Daniel Cushman, John Hendrick, Masaru Teramoto, Benjamin Fogg, Sean Bradley, Colby Hansen
OBJECTIVE: This study aimed to identify the Balance Error Scoring System's (BESS) intraclass reliability in a cohort of patients with prolonged symptoms using variance component analysis and intraclass correlation coefficient (ICC). SETTING: Outpatient sports medicine/concussion clinic. PARTICIPANTS: A total of 241 paediatric and 102 adult patients with symptoms lasting longer than 10 days. INTERVENTIONS: BESS testing...
February 2, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29388838/untangling-chronic-pain-and-post-concussion-symptoms-the-significance-of-depression
#6
Deborah L Snell, Rachelle Martin, A D Macleod, Lois J Surgenor, Richard J Siegert, E Jean C Hay-Smith, Tracy Melzer, Gary J Hooper, Tim Anderson
OBJECTIVES: Post-concussion-like symptoms (PCS) are common in patients without a history of brain injury, such as those with chronic pain (CP). This exploratory study examined neuro-cognitive and psychological functioning in patients with PCS following mild traumatic brain injury (mTBI) or CP, to assess unique and overlapping phenomenology. METHODS: In this case-control study, participants (n = 102) with chronic symptoms after mTBI (n = 45) were matched with mTBI recovered (n = 31) and CP groups (n = 26), on age, gender, ethnicity and education...
February 1, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29385179/population-based-cohort-study-of-the-impacts-of-mild-traumatic-brain-injury-in-adults-four-years-post-injury
#7
Alice Theadom, Nicola Starkey, Suzanne Barker-Collo, Kelly Jones, Shanthi Ameratunga, Valery Feigin
There is increasing evidence that some people can experience persistent symptoms for up to a year following mild TBI. However, few longitudinal studies of mild TBI exist and the longer-term impact remains unclear. The purpose of this study is to determine if there are long-term effects of mild traumatic brain injury (TBI) four-years later. Adults (aged ≥16 years) identified as part of a TBI incidence study who experienced a mild-TBI four-years ago (N = 232) were compared to age-sex matched controls (N = 232)...
2018: PloS One
https://www.readbyqxmd.com/read/29376093/lifelong-behavioral-and-neuropathological-consequences-of-repetitive-mild-traumatic-brain-injury
#8
Benoit C Mouzon, Corbin Bachmeier, Joseph O Ojo, Christopher M Acker, Scott Ferguson, Daniel Paris, Ghania Ait-Ghezala, Gogce Crynen, Peter Davies, Michael Mullan, William Stewart, Fiona Crawford
Objective: Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been linked with increased risk of long-term neurodegenerative changes, specifically chronic traumatic encephalopathy (CTE). To date, preclinical studies largely have focused on the immediate aftermath of mTBI, with no literature on the lifelong consequences of mTBI in these models. This study provides the first account of lifelong neurobehavioral and histological consequences of repetitive mTBI providing unique insight into the constellation of evolving and ongoing pathologies with late survival...
January 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29374978/misconceptions-about-traumatic-brain-injury-among-educators-has-anything-changed-over-the-last-20-years
#9
Audrey McKinlay, Kimberly Buck
PURPOSE: To examine educational professionals' knowledge and understanding of childhood brain injury. MATERIALS AND METHODS: Educational professionals from all schools in the state of Victoria, Australia, were invited to participate in an online cross-sectional survey consisting of 20 questions assessing knowledge of concussion and 30 questions examining knowledge of traumatic brain injury (n = 364). RESULTS: On average, participants correctly answered 16/20 (80%) questions about concussion and 24...
January 28, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29373947/reduced-functional-connectivity-in-adults-with-persistent-post-concussion-symptoms-a-functional-near-infrared-spectroscopy-study
#10
Lia Maria Hocke, Chris C Duszynski, Chantel T Debert, Diane Dleikan, Jeffrey F Dunn
Concussion, or mild traumatic brain injury (mTBI), accounts for approximately 80% of all traumatic brain injuries across North America. The majority of mTBI patients recover within days to weeks, however, 14-36% of the time acute mTBI symptoms persist for months or even years and develop into persistent post-concussion symptoms (PPCS). There is a need to find biomarkers in patients with PPCS, to improve prognostic ability and to provide insight into the pathophysiology underlying chronic symptoms. Recent research has pointed towards impaired network integrity and cortical communication as a biomarker...
January 26, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29368186/protection-before-impact-the-potential-neuroprotective-role-of-nutritional-supplementation-in-sports-related-head-trauma
#11
REVIEW
Jonathan M Oliver, Anthony J Anzalone, Stephanie M Turner
Even in the presence of underreporting, sports-related concussions/mild traumatic brain injuries (mTBI) are on the rise. In the absence of proper diagnosis, an athlete may return to play prior to full recovery, increasing the risk of second-impact syndrome or protracted symptoms. Recent evidence has demonstrated that sub-concussive impacts, those sustained routinely in practice and competition, result in a quantifiable pathophysiological response and the accumulation of both concussive and sub-concussive impacts sustained over a lifetime of sports participation may lead to long-term neurological impairments and an increased risk of developing neurodegenerative diseases...
January 24, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29360998/concussion-microvascular-injury-and-early-tauopathy-in-young-athletes-after-impact-head-injury-and-an-impact-concussion-mouse-model
#12
Chad A Tagge, Andrew M Fisher, Olga V Minaeva, Amanda Gaudreau-Balderrama, Juliet A Moncaster, Xiao-Lei Zhang, Mark W Wojnarowicz, Noel Casey, Haiyan Lu, Olga N Kokiko-Cochran, Sudad Saman, Maria Ericsson, Kristen D Onos, Ronel Veksler, Vladimir V Senatorov, Asami Kondo, Xiao Z Zhou, Omid Miry, Linnea R Vose, Katisha R Gopaul, Chirag Upreti, Christopher J Nowinski, Robert C Cantu, Victor E Alvarez, Audrey M Hildebrandt, Erich S Franz, Janusz Konrad, James A Hamilton, Ning Hua, Yorghos Tripodis, Andrew T Anderson, Gareth R Howell, Daniela Kaufer, Garth F Hall, Kun P Lu, Richard M Ransohoff, Robin O Cleveland, Neil W Kowall, Thor D Stein, Bruce T Lamb, Bertrand R Huber, William C Moss, Alon Friedman, Patric K Stanton, Ann C McKee, Lee E Goldstein
The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic encephalopathy, and the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes in the acute-subacute period after mild closed-head impact injury and found astrocytosis, myelinated axonopathy, microvascular injury, perivascular neuroinflammation, and phosphorylated tau protein pathology. To investigate causal mechanisms, we developed a mouse model of lateral closed-head impact injury that uses momentum transfer to induce traumatic head acceleration...
January 18, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29357779/adversity-and-resilience-are-associated-with-outcome-following-mild-traumatic-brain-injury-in-military-service-members
#13
Matthew Wade Reid, Douglas Cooper, Lisa H Lu, Grant L Iverson, Jan Kennedy
The objective of this study was to assess the associations between resilience, adversity, post-concussion symptoms, and posttraumatic stress symptom reporting following mild traumatic brain injury (mTBI). We hypothesized that resilience would be associated with less symptom reporting and adversity would be associated with greater symptom reporting. This was a cross-sectional study of retrospective data collected for an ongoing TBI repository. US military service members who screened positive for mTBI during a primary care visit completed the Trauma History Screen (THS), Connor-Davidson Resilience Scale (CD-RISC), Neurobehavioral Symptom Inventory (NSI), and PTSD Checklist-Civilian Version (PCL-C)...
January 22, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29357456/network-disruption-following-mild-traumatic-brain-injury-clinical-and-experimental-research-implications
#14
Casey Swick, Tiffany Andersen, Ana-Mercedes Flores
Illuminating the pathophysiological mechanisms that underlie persistent post concussive symptoms following mild traumatic brain injury (mTBI) is a growing area of study. Alhourani et al. (J Neurophysiol 116: 1840-1847, 2016) added to this emerging body of literature with their study examining default mode network (DMN) disruption in mTBI using magnetoencephalography. The findings provided enhanced insight into the neural underpinnings of mTBI , which can be applied to future clinical and experimental research in this area...
January 3, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29357446/network-disruption-following-mild-traumatic-brain-injury-clinical-and-experimental-research-implications
#15
Casey Swick, Tiffany Andersen, Ana-Mercedes Flores
Illuminating the pathophysiological mechanisms that underlie persistent post concussive symptoms following mild traumatic brain injury (mTBI) is a growing area of study. Alhourani et al. (J Neurophysiol 116: 1840-1847, 2016) added to this emerging body of literature with their study examining default mode network (DMN) disruption in mTBI using magnetoencephalography. The findings provided enhanced insight into the neural underpinnings of mTBI, which can be applied to future clinical and experimental research in this area...
January 10, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29355392/factor-structure-of-the-rivermead-post-concussion-symptoms-questionnaire-over-the-first-year-following-mild-traumatic-brain-injury
#16
Suzanne Barker-Collo, Alice Theadom, Nicola Starkey, Michael Kahan, Kelly Jones, Valery Feigin
BACKGROUND: We examined the factor structure of the Rivermead Post-Concussion Symptom Questionnaire (RPQ), the most commonly used measure of post-concussive symptoms, over the first year post-injury. METHOD: Factor analysis (orthogonal rotation) was used to examine the RPQ items that form coherent subsets/factors within 2-weeks, and 1, 6, and 12-months post-mTBI in 527 adults (age >16 years). RESULTS: At baseline, three factors accounted for 63...
January 22, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29350085/divergent-classification-methods-of-post-concussion-syndrome-after-mild-traumatic-brain-injury-prevalence-rates-risk-factors-and-functional-outcome
#17
Daphne Cloë Voormolen, Maryse C Cnossen, Suzanne Polinder, Nicole von Steinbuechel, Pieter E Vos, Juanita Antje Haagsma
Mild Traumatic Brian Injury (mTBI) is a common diagnosis and approximately one third of mTBI patients experience a variety of cognitive, emotional, psychosocial and behavioral post-concussion symptoms. When a cluster of these symptoms persists for more than three months they are often classified as post-concussion syndrome (PCS). The objective of this study was to determine prevalence rates, risk factors and functional outcome associated with PCS six months after mTBI applying divergent classification methods...
January 19, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29349651/epidemiology-of-head-injuries-focusing-on-concussions-in-team-contact-sports-a-systematic-review
#18
REVIEW
Annika Prien, Alexander Grafe, Roland Rössler, Astrid Junge, Evert Verhagen
BACKGROUND: Although injuries to the head represent a small proportion of all sport injuries, they are of great concern due to their potential long-term consequences, which are even suspected in mild traumatic brain injuries. OBJECTIVE: The aim of this review was to compare the incidence of concussions and other head injuries in elite level football, rugby, ice hockey and American Football. METHODS: Four electronic databases (CINAHL, PsycINFO, Web of Science, PubMed) were searched...
January 18, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29336197/neurosensory-deficits-vary-as-a-function-of-point-of-care-in-pediatric-mild-traumatic-brain-injury
#19
Andrew Mayer, Chris Wertz, Sephira Ryman, Eileen Storey, Grace Park, John Phillips, Andrew Burke Dodd, Scott Oglesbee, Richard Campbell, Ron Yeo, Ben Wasserott, Nicholas Shaff, John J Leddy, Rebekah Mannix, Kristy B Arbogast, Timothy Meier, Matthew Grady, Christina Master
Neurosensory abnormalities are frequently observed following pediatric mild traumatic brain injury (pmTBI) and may underlie the expression of several common concussion symptoms and delay recovery. Importantly, active evaluation of neurosensory functioning more closely approximates real-world (e.g., physical and academic) environments that provoke symptom-worsening. The current study determined whether symptom provocation (i.e., during neurosensory exam) improved classification accuracy relative to pre-exam symptom levels and whether symptoms varied as a function of point of care...
January 16, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29318971/-phenserine-and-inhibiting-pre-programmed-cell-death-in-pursuit-of-a-novel-intervention-for-alzheimer-s-disease
#20
Robert E Becker, Nigel H Greig, Debomoy K Lahiri, Joseph Bledsoe, Sarah Majercik, Clive Ballard, Dag Aarsland, Lon S Schneider, Douglas Flanagan, Ramprakash Govindarajan, Mary Sano, Luigi Ferrucci, Dimitrios Kapogiannis
BACKGROUND: Concussion (mild) and other moderate traumatic brain injury (TBI) and Alzheimer's disease (AD) share overlapping neuropathologies, including neuronal pre-programmed cell death (PPCD), and clinical impairments and disabilities. Multiple clinical trials targeting mechanisms based on the Amyloid Hypothesis of AD have so far failed, indicating that it is prudent for new drug developments to also pursue mechanisms independent of the Amyloid Hypothesis. To address these issue, we have proposed the use of an animal model of concussion/TBI as a supplement to AD transgenic mice to provide an indication of an AD drug candidate's potential for preventing PPCD and resulting progression towards dementia in AD...
January 10, 2018: Current Alzheimer Research
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