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https://www.readbyqxmd.com/read/29445503/overview-of-occupational-cancer-in-painters-in-korea
#1
REVIEW
Jun-Pyo Myong, Younmo Cho, Min Choi, Hyoung-Ryoul Kim
Comprehensive consideration is necessary for setting guidelines to evaluate evidence of occupational cancer in painters due to work-related exposure to carcinogens in paint (a phenomenon termed herein as "work-relatedness"). The aim of the present research is to perform a comprehensive review and to suggest criteria for the provision of compensation for occupational neoplasm among painters in Korea. In order to perform a comprehensive review, this study assessed and evaluated scientific reports of carcinogenicities from the International Agency for Research on Cancer (IARC) and the Industrial Injuries Advisory Council (IIAC), as well as reviewed the existing literature about occupational exposure among painters in Korea and the epidemiologic investigations of claimed cases of cancer among painters in Korea...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29260472/environmental-and-biological-monitoring-of-exposures-to-vocs-in-a-petrochemical-complex-in-iran
#2
Yaghoub Hajizadeh, Hakimeh Teiri, Shahrokh Nazmara, Iman Parseh
Exposure to volatile organic compounds (VOCs) can cause cancers in human. This study aimed to measure the concentration of four VOCs including benzene, styrene, ethylbenzene, and phenol in ambient air of a petrochemical complex in Iran. Also, their urinary metabolites including phenol, mandelic acid (MA), and phenylglyoxylic acid (PGA) in the workers were monitored. Urine samples were collected before and after the 8-h workshift according to the NIOSH methods. They were analyzed by a gas chromatograph coupled with a flame ionization detector (GC-FID)...
December 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29153889/3d-qsar-studies-on-indole-and-7-azoindole-derivatives-as-rock-2-inhibitors-an-integrative-computational-approach
#3
Santhosh Kumar Nagarajan, Sathya Babu, Honglae Sohn, Panneer Devaraju, Thirumurthy Madhavan
Rho Kinases (ROCK) has been found to regulate a wide range of fundamental cell functions such as contraction, motility, proliferation, and apoptosis. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states. In this study, we have performed pharmacophore modeling and 3D QSAR studies on a series of 36 indoles and 7-azoindoles derivatives as ROCK2 inhibitors to elucidate the structural variations with their inhibitory activities...
October 9, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28941718/a-multi-year-study-of-voc-emissions-at-a-chemical-waste-disposal-facility-using-mobile-apci-ms-and-lpci-ms-instruments
#4
Robert M Healy, QingFeng Chen, Julie Bennett, Nicholas S Karellas
Real-time analysis of volatile organic compounds (VOCs) in air is useful both for source identification and emissions compliance applications. In this work, two complementary triple quadrupole mass spectrometers, fitted with an atmospheric pressure chemical ionization (APCI) and a low pressure chemical ionization (LPCI) source, respectively, were deployed simultaneously to investigate emissions of VOCs associated with an Ontario-based chemical waste disposal facility. Mobile measurements performed upwind and downwind of the facility enabled selection of the best locations for stationary sampling...
September 20, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28678614/emission-from-open-burning-of-municipal-solid-waste-in-india
#5
Kanchan Kumari, Sunil Kumar, R Vineel, Ankur Khare, Rakesh Kumar
Open burning of Municipal Solid Waste (MSW) is a potential non-point source of emission, which causes greater concern especially in developing countries like India. The lack of awareness about environmental impact of open burning among the public, and ignorance of the fact i.e., "Open burning is a source of emission of carcinogenic substances" by environmental organizations are major hindrances towards appropriate municipal solid waste management (MSWM) system in India. The present paper highlights about the open burning of MSW practices in India, the current and projected emission of 10 major pollutants, namely dioxin, furans, particulate matter, carbon monoxide, sulphur oxides, nitrogen oxides, benzene, toluene, ethyl benzene and 1-hexene emitted due to the open burning of MSW...
July 5, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28561292/guideline-for-the-diagnosis-and-treatment-of-scabies-in-japan-third-edition-executive-committee-of-guideline-for-the-diagnosis-and-treatment-of-scabies
#6
(no author information available yet)
In the current work, we present our new guideline for the diagnosis and treatment of scabies which we, the Executive Committee convened by the Japanese Dermatological Association, developed to ensure proper diagnosis and treatment of scabies in Japan. Approval of phenothrin topical use under the National Health Insurance in August 2014 led to this action. Permethrin, a topical anti-scabietic medication belonging to the same pyrethroid group as phenothrin, is already in use worldwide. In this guideline, we introduce criteria for a proper diagnosis of scabies, treatment algorithm for common and crusted (hyperkeratotic) scabies, and prevention...
September 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28502046/adapting-the-vegetative-vigour-terrestrial-plant-test-for-assessing-ecotoxicity-of-aerosol-samples
#7
Nora Kováts, Eszter Horváth, Bettina Eck-Varanka, Eszter Csajbók, András Hoffer
Plants, being recognized to show high sensitivity to air pollution, have been long used to assess the ecological effects of airborne contaminants. However, many changes in vegetation are now generally attributed to atmospheric deposition of aerosol particles; the dose-effect relationships of this process are usually poorly known. In contrast to bioindication studies, ecotoxicological tests (or bioassays) are controlled and reproducible where ecological responses are determined quantitatively. In our study, the No...
June 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28417329/quantitative-cancer-risk-assessment-and-local-mortality-burden-for-ambient-air-pollution-in-an-eastern-mediterranean-city
#8
Hassan R Dhaini, Thérèse Salameh, Antoine Waked, Stéphane Sauvage, Agnès Borbon, Paola Formenti, Jean-François Doussin, Nadine Locoge, Charbel Afif
Health risks posed by ambient air pollutants to the urban Lebanese population have not been well characterized. The aim of this study is to assess cancer risk and mortality burden of non-methane hydrocarbons (NMHCs) and particulates (PM) based on two field-sampling campaigns conducted during summer and winter seasons in Beirut. Seventy NMHCs were analyzed by TD-GC-FID. PM2.5 elemental carbon (EC) components were examined using a Lab OC-EC aerosol Analyzer, and polycyclic aromatic hydrocarbons were analyzed by GC-MS...
June 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28402363/on-the-validity-of-linear-response-approximations-regarding-the-solvation-dynamics-of-polyatomic-solutes
#9
Esther Heid, Wanda Moser, Christian Schröder
The time-dependent fluorescence of a chromophore can be calculated from either nonequilibrium simulations, or, as long as linear response theory holds true, from equilibrium solvent fluctuations in the ground or excited state if the perturbation inflicted by the chromophore is small. The assumption of Gaussian statistics, in contrast, links the nonequilibrium dynamics to solvent fluctuations solely in the excited state, as long as the energy gap distribution is Gaussian throughout the process. The validity of linear response theories on the ground and excited state surface as well as Gaussian statistics is thoroughly tested in this study by calculating the time-dependent Stokes shift of different benzene-like solutes...
May 3, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28375613/thieno-3-4-b-thiophene-based-novel-small-molecule-optoelectronic-materials
#10
Cheng Zhang, Xiaozhang Zhu
Because of the tailorable photoelectric properties derived from judicious molecular design and large-area and low-temperature processability especially on flexible substrates, design and synthesis of new organic π-functional materials is always a central topic in the field of organic optoelectronics, which siginificantly contributed to the development of high-performance optoelectronic devices such as organic photovoltaics (OPVs), organic field-effect transistors (OFETs), and organic light-emitting diodes (OLEDs)...
April 4, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28236484/characterization-and-source-profiling-of-volatile-organic-compounds-in-indoor-air-of-private-residences-in-selangor-state-malaysia
#11
Nobumitsu Sakai, Shuta Yamamoto, Yasuto Matsui, Md Firoz Khan, Mohd Talib Latif, Mustafa Ali Mohd, Minoru Yoneda
Volatile Organic Compounds (VOCs) in indoor air were investigated at 39 private residences in Selangor State, Malaysia to characterize the indoor air quality and to identify pollution sources. Twenty-two VOCs including isomers (14 aldehydes, 5 aromatic hydrocarbons, acetone, trichloroethylene and tetrachloroethylene) were collected by 2 passive samplers for 24h and quantitated using high performance liquid chromatography and gas chromatography mass spectrometry. Source profiling based on benzene/toluene ratio as well as statistical analysis (cluster analysis, bivariate correlation analysis and principal component analysis) was performed to identify pollution sources of the detected VOCs...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28235390/qsar-analysis-for-6-arylpyrazine-2-carboxamides-as-trypanosoma-brucei-inhibitors
#12
V H Masand, N N E El-Sayed, D T Mahajan, V Rastija
Human African trypanosomiasis (HAT) is prevalent in African countries, covering 37 countries, mostly sub-Saharan. A limited number of drugs are available to cure this neglected disease. In the present work, quantitative structure-activity (toxicity) relationships (QSA(T)R) analysis has been performed for a dataset of 54 6-arylpyrazine-2-carboxamides as Trypanosoma brucei inhibitors to identify the important structural features required for future optimization of lead candidates. The QSA(T)R models satisfy OECD guidelines and have high statistical robustness...
February 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28063708/infants-indoor-and-outdoor-residential-exposure-to-benzene-and-respiratory-health-in-a-spanish-cohort
#13
Amparo Ferrero, Ana Esplugues, Marisa Estarlich, Sabrina Llop, Amparo Cases, Enrique Mantilla, Ferran Ballester, Carmen Iñiguez
Benzene exposure represents a potential risk for children's health. Apart from being a known carcinogen for humans (group 1 according to IARC), there is scientific evidence suggesting a relationship between benzene exposure and respiratory problems in children. But results are still inconclusive and inconsistent. This study aims to assess the determinants of exposure to indoor and outdoor residential benzene levels and its relationship with respiratory health in infants. Participants were 1-year-old infants (N = 352) from the INMA cohort from Valencia (Spain)...
March 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27866741/assessment-of-indoor-air-quality-in-office-buildings-across-europe-the-officair-study
#14
Corinne Mandin, Marilena Trantallidi, Andrea Cattaneo, Nuno Canha, Victor G Mihucz, Tamás Szigeti, Rosanna Mabilia, Erica Perreca, Andrea Spinazzè, Serena Fossati, Yvonne De Kluizenaar, Eric Cornelissen, Ioannis Sakellaris, Dikaia Saraga, Otto Hänninen, Eduardo De Oliveira Fernandes, Gabriela Ventura, Peder Wolkoff, Paolo Carrer, John Bartzis
The European project OFFICAIR aimed to broaden the existing knowledge regarding indoor air quality (IAQ) in modern office buildings, i.e., recently built or refurbished buildings. Thirty-seven office buildings participated in the summer campaign (2012), and thirty-five participated in the winter campaign (2012-2013). Four rooms were investigated per building. The target pollutants were twelve volatile organic compounds, seven aldehydes, ozone, nitrogen dioxide and particulate matter with aerodynamic diameter <2...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27860299/validation-of-a-new-high-throughput-method-to-determine-urinary-s-phenylmercapturic-acid-using-low-temperature-partitioning-extraction-and-ultra-high-performance-liquid-chromatography-mass-spectrometry
#15
Rafaela de Paiva Gomes, Camila Bárbara Pena, Jennifer Rezende, Mauricio Xavier Coutrim, Robson José de Cássia Franco Afonso
A new highly sensitive and environmentally friendly analytical method, using low-temperature partition extraction and ultra-high-performance liquid chromatography with tandem mass spectrometry, without the use of a labeled analyte, was developed and validated to determine and quantify urinary S-phenylmercapturic acid in urine samples. The World Health Organization, in its guidelines for air quality in Europe, recognizes that benzene is carcinogenic to humans and there is no safe level of exposure. Urinary S-phenylmercapturic acid is a sensitive and specific biological marker of exposure to benzene...
January 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/27796456/development-of-quechers-based-extraction-and-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-quantification-of-bisphenol-a-and-tetrabromobisphenol-a-in-seafood-fish-bivalves-and-seaweeds
#16
Sara C Cunha, Cátia Oliveira, José O Fernandes
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of bisphenol A (BPA) and tetrabromobisphenol A (TBBPA) in different seafood samples was developed and validated. Sample preparation was based on a quick, easy, cheap, effective, rugged, and safe (QuEChERS)-based procedure through an extraction of target analytes with acidified acetonitrile (MeCN) added with inorganic salts (MgSO4, NaCl) followed by a liquid-liquid extraction (LLE) using hexane-tertbutylmethyl ether/hexane-benzene to eliminate matrix co-extracts...
January 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27761924/visualizing-dispersion-interactions-through-the-use-of-local-orbital-spaces
#17
Axel Wuttke, Ricardo A Mata
The interpretation of chemical properties/phenomena can often be aided through the use of imagery. The mapping of molecular electrostatic potentials is a prime example, serving as a guideline in the design of novel compounds or understanding transition state stabilization effects. It is today a common tool for theoreticians and experimentalists alike. With the emergence of concepts such as dispersion energy donors, and the overall importance of dispersion in chemical systems, representations targeting such a class of interactions are warranted...
January 5, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/27662836/biodegradation-of-nonionic-and-anionic-surfactants-in-domestic-wastewater-under-simulated-sewer-conditions
#18
Jennifer Z Menzies, Kathleen McDonough, Drew McAvoy, Thomas W Federle
The ultimate disposition of chemicals discarded down the drain can be substantially impacted by their fate in the sewer, but to date limited data have been published on the biodegradability of chemicals in sewer systems. The recently established OECD 314 guideline (Simulation tests to assess the biodegradability of chemicals discharged in wastewater, 2008) contains a simulation method (314A) for evaluating the biodegradation of chemicals in sewage under simulated sewer conditions. This research used the OECD 314A method to evaluate the rates and pathways of primary and ultimate biodegradation of a suite of (14)C-labeled homologues representing four classes of high volume surfactants including nonionic alkyl ethoxylates (AE), and anionic alkyl ethoxysulfates (AES), alkyl sulfate (AS) and linear alkyl benzene sulfonate (LAS)...
February 2017: Biodegradation
https://www.readbyqxmd.com/read/27659059/voc-exposures-in-california-early-childhood-education-environments
#19
T Hoang, R Castorina, F Gaspar, R Maddalena, P L Jenkins, Q Zhang, T E McKone, E Benfenati, A Y Shi, A Bradman
Little information exists about exposures to volatile organic compounds (VOCs) in early childhood education (ECE) environments. We measured 38 VOCs in single-day air samples collected in 2010-2011 from 34 ECE facilities serving California children and evaluated potential health risks. We also examined unknown peaks in the GC/MS chromatographs for indoor samples and identified 119 of these compounds using mass spectral libraries. VOCs found in cleaning and personal care products had the highest indoor concentrations (d-limonene and decamethylcyclopentasiloxane [D5] medians: 33...
September 22, 2016: Indoor Air
https://www.readbyqxmd.com/read/27616782/development-and-validation-of-a-uhplc-uv-method-for-the-in-process-control-of-bosentan-monohydrate-synthesis
#20
Marta Jatczak, Katarzyna Sidoryk, Magdalena Kossykowska, Wojciech Łuniewski, Joanna Zagrodzka, Elżbieta Lipiec-Abramska
Bosentan monohydrate (4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl) pyrimidin-4-yl]benzene-1-sulfonamide monohydrate) is a dual endothelin receptor antagonist (ERA) applied in the treatment of pulmonary arterial hypertension. To achieve effective process control of the bosentan monohydrate synthesis, it was necessary to develop a selective and not highly time-consuming method for ultra-high performance liquid chromatography (UHPLC). The method is characterized by adequate sensitivity, reproducibility and selectivity for the determination of bosentan monohydrate and related compounds from all synthetic stages...
2016: Chromatographia
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