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https://www.readbyqxmd.com/read/29153041/association-of-procalcitonin-values-and-bacterial-infections-in-pediatric-patients-receiving-extracorporeal-membrane-oxygenation
#1
Vi Ean Tan, Wayne S Moore, Arun Chopra, Jeffrey J Cies
OBJECTIVE: There is increasing data in pediatrics demonstrating procalcitonin (PCT) is more sensitive and specific than other biomarkers in the setting of bacterial infections. However, the use of PCT in neonatal and pediatric extracorporeal membrane oxygenation (ECMO) is not well described. Therefore, the purpose of this study was to describe the clinical utility of PCT in determining the absence or presence of bacterial infections in neonatal and pediatric patients on ECMO. METHODS: This was a retrospective electronic medical record (EMR) review of data between January 1, 2010 to June 30, 2016 at a single, free-standing, children 's hospital...
November 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29153038/a-divergent-pseudoglandular-configuration-of-cutaneous-plasmacytoma-in-dogs
#2
Brittany McHale, Uriel Blas-Machado, Fabiano N Oliveira, Daniel R Rissi
Cutaneous and mucocutaneous plasmacytoma (PCT) is a common neoplasm of dogs. Tumors can be single or multiple and occur predominantly in the oral cavity, lip, ears, digits, and trunk. Although these tumors typically offer no diagnostic challenge for the pathologist, subsets of PCTs with atypical morphologic configurations may make differentiation from other neoplasms difficult. We describe 6 cases of canine cutaneous and mucocutaneous PCT with pseudoglandular arrangement of neoplastic cells. The mean age of affected dogs was 11...
November 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29152226/an-overview-of-the-cutaneous-porphyrias
#3
REVIEW
Robert Dawe
This is an overview of the cutaneous porphyrias. It is a narrative review based on the published literature and my personal experience; it is not based on a formal systematic search of the literature. The cutaneous porphyrias are a diverse group of conditions due to inherited or acquired enzyme defects in the porphyrin-haem biosynthetic pathway. All the cutaneous porphyrias can have (either as a consequence of the porphyria or as part of the cause of the porphyria) involvement of other organs as well as the skin...
2017: F1000Research
https://www.readbyqxmd.com/read/29151414/-efficacy-of-noninvasive-ventilation-on-treatment-of-ards-caused-by-severe-pneumonia-after-kidney-transplantation
#4
Xiaoshu Liu, Zhengliang Xie, Hong Teng, Lijuan Chen, Jing Zhang
OBJECTIVE: To observe the clinical efficacy of noninvasive ventilation (NIV) on the treatment of acute respiratory distress syndrome (ARDS) caused by severe pneumonia after kidney transplantation. METHODS: The clinical data of 17 patients who were diagnosed as ARDS caused by severe pneumonia after kidney transplantation and treated with NIV in Sichuan Provincial People's Hospital from January 1st, 2014 to June 1st, 2016 were collected and retrospectively analyzed...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29148026/the-influence-of-hemodialysis-membrane-permeability-on-serum-procalcitonin-values-in-patients-on-maintenance-hemodialysis
#5
Taoufiq Aatif, Yassir Zajjari, Anas Jeaidi
BACKGROUND: Procalcitonin (PCT) has emerged as a marker of infection and it could be useful for detection of systemic bacterial infections in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD). The aim of this study was to assess the influence of HD membrane permeability to PCT serum levels in noninfected HD patients on maintenance HD. METHODS: In a prospective comparative study, we measured PCT serum levels and C reactive protein (CRP) before and after HD in 36 sessions (18 sessions of HD with low-flux = Group L; and 18 sessions with high flux membranes = Group H), in 18 chronic HD patients without history of infection...
November 9, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29141376/-clinical-significance-of-acute-gastrointestinal-injury-grades-in-inflammatory-response-of-critically-ill-patients
#6
J Wang, Y L Gao, W W Yu, Y H Xia, Y Z Sun
Objective: To explore the value of acute gastrointestinal injury (AGI) grades in inflammatory response of critically ill patients. Methods: Ptients with AGI severity from Ⅰ to Ⅳ were randomly selected(20 for each)from July 2014 to June 2015 in ICU of Yantai Yuhuangding Hospital. The expression of NF-κB were detected by immunofluorescence. The expression of TNF-α and IL-6 were detected by enzyme linked immunosorbent assay (ELISA). Procalcitonin (PCT) and C reactive protein (CRP) were measured. Statistical analysis was carried out...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29138696/use-of-common-inflammatory-markers-in-the-long-term-screening-of-total-hip-arthroprosthesis-infections-our-experience
#7
Gabriele Falzarano, Antonio Piscopo, Predrag Grubor, Giuseppe Rollo, Antonio Medici, Valerio Pipola, Michele Bisaccia, Auro Caraffa, Elizabeth Mary Barron, Francesco Nobile, Raffaele Cioffi, Luigi Meccariello
Orthopedic implants have become essential components of modern medicine. The risk of infection of total hip arthroplasty (THA) is 1.5%-2%. Are the C-reactive protein (CRP), the erythrocyte sedimentation rate (ESR), and procalcitonin (PCT) good markers for THA infection screenings? From February 2009 to December 2012 at our Department of Orthopedics and Traumatology, 1248 patients were treated with THA. No prosthesis was cemented. All patients received antibiotic prophylaxis. All patients were discharged approximately 7...
2017: Advances in Orthopedics
https://www.readbyqxmd.com/read/29137663/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-worldwide-patent-families
#8
Folahanmi Tomiwa Akinsolu, Vitor Nobre de Paiva, Samuel Santos Souza, Orsolya Varga
BACKGROUND: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws...
November 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29137405/necroptosis-regulated-proteins-expression-is-an-early-prognostic-biomarker-in-patient-with-sepsis-a-prospective-observational-study
#9
Bing Wang, Jian Li, Hong-Mei Gao, Ying-Hong Xing, Zhu Lin, Hong-Jie Li, Yong-Qiang Wang
Background and aim: Increasing researchers indicate that necroptosis is playing an important role in the regulation of systemic inflammatory response syndrome. The current study was to investigate the prognostic biomarker of the regulated proteins of necroptosis in sepsis patients. Results: One hundred and twenty-four patients were divided into three groups: 43 patients (34.68%) with sepsis, 39 patients (31.45%) with severe sepsis, and 42 patients (33.87%) with septic shock...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136708/-analysis-of-risk-factors-related-to-the-prognosis-in-patients-with-late-onset-severe-pneumonia-after-allogeneic-hematopoietic-stem-cell-transplantation
#10
Y Chen, Y Wang, Z H Jiang, L P Xu, X H Zhang, H Chen, Y Y Chen, F R Wang, J Z Wang, W Han, Y Y Zhang, T T Han, F F Tang, X D Mo, Y Q Sun, C H Yan, K Y Liu, X J Huan
Objective: To investigate the prognostic factors of late-onset severe pneumonia (LOSP) in patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: From January 2009 to December 2015, 68 patients with LOSP after allo-HSCT at Peking University Institute of Hematology were enrolled. In this retrospective study, univariate and multivariate analysis were used to evaluate the prognostic factors for LOSP after allo-HSCT. Results: The median time from allo-HSCT to the development of LOSP was 213 (90-2 330) days...
November 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29133844/utilization-of-stainless-steel-furnace-dust-as-an-admixture-for-synthesis-of-cement-based-electromagnetic-interference-shielding-composites
#11
Yong Fan, Ling Zhang, Vladimir Volski, Guy A E Vandenbosch, Bart Blanpain, Muxing Guo
Electromagnetic interference (EMI) shielding receives attention due to the increasing abundance of electronics. The Cement based material can obtain EMI shielding properties through the use of appropriate "fillers" such as carbon, metal, and ferrite. As the most important by-product of stainless steelmaking operations, through the metal droplets and ferrite that it contains, stainless-steel dust can be considered as a potential filler for EMI shielding applications. We have therefore utilized stainless-steel dust as an admixture for the synthesis of cement-based EMI shielding composites and show that it raises the EMI shielding effectiveness...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133757/soluble-triggering-receptor-expressed-on-myeloid-cells-1-and-inflammatory-markers-in-colorectal-cancer-surgery-a-prospective-cohort-study
#12
Lovorka Ðerek, Dražen Servis, Adriana Unić
BACKGROUND: Major abdominal surgery, including colorectal cancer (CRC) surgery, leads to systemic inflammatory response syndrome that can be detected and monitored with inflammatory markers testing. The aims of the study were to evaluate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) in following the inflammatory response in CRC surgery and postoperative period, as well as to determine if duration of the surgery and the time that the colon has been opened during the surgery (open colon time [OCT]) reflect a larger surgical stress through inflammatory markers rise...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29132765/cortical-thinning-correlates-of-changes-in-visuospatial-and-visuoperceptual-performance-in-parkinson-s-disease-a-4-year-follow-up
#13
A I Garcia-Diaz, B Segura, H C Baggio, C Uribe, A Campabadal, A Abos, M J Marti, F Valldeoriola, Y Compta, N Bargallo, C Junque
BACKGROUND: Growing evidence highlights the relevance of posterior cortically-based cognitive deficits in Parkinson's disease (PD) as possible biomarkers of the evolution to dementia. Cross-sectional correlational studies have established a relationship between the degree of atrophy in posterior brain regions and visuospatial and visuoperceptual (VS/VP) impairment. The aim of this study is to address the progressive cortical thinning correlates of VS/VP performance in PD. METHODS: Forty-four PD patients and 20 matched healthy subjects were included in this study and followed for 4 years...
November 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29128649/design-of-a-randomized-controlled-trial-examining-the-efficacy-and-biological-mechanisms-of-web-prolonged-exposure-and-present-centered-therapy-for-ptsd-among-active-duty-military-personnel-and-veterans
#14
Carmen P McLean, Sheila A M Rauch, Edna B Foa, Rebecca K Sripada, Hallie S Tannahill, Jim Mintz, Jeffrey Yarvis, Stacey Young-McCaughan, Katherine A Dondanville, Brittany N Hall-Clark, Brooke A Fina, Terence M Keane, Alan L Peterson
Improved accessibility of effective and efficient evidence-based treatments (EBTs) for military personnel suffering with posttraumatic stress disorder (PTSD) is an urgent need to meet the growing demand for timely care. In addition, a better understanding of the mechanism of action of behavioral therapy can inform the delivery of care to meet accessibility demands. Effective EBTs for PTSD are available, but logistical and stigma-related barriers to accessing behavioral healthcare can deter military personnel from receiving these treatments...
November 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29123872/serum-levels-of-interleukin-6-may-predict-organ-dysfunction-earlier-than-sofa-score
#15
Takashi Shimazui, Yosuke Matsumura, Taka-Aki Nakada, Shigeto Oda
Aim: To investigate the clinical utility of interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) as predictive markers in consideration of the time-course changes in critically ill patients with organ dysfunction. Methods: Serum levels of IL-6, PCT, CRP, and Sequential Organ Failure Assessment (SOFA) scores were measured sequentially in 92 patients during their initial 5 days following admission to the intensive care unit. Maximum values were analyzed...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29120248/the-evaluation-of-anatomic-and-functional-changes-in-unilateral-moderate-amblyopic-eyes-using-optical-coherence-tomography-and-pupil-cycle-time
#16
Tuncay Kusbeci, Omer Karti, Eyyup Karahan, Mustafa Oguztoreli
PURPOSE: To investigate whether macular anatomic structure and afferent visual system function differ among amblyopic eyes, non-amblyopic fellow eyes, and controls, using spectral-domain optical coherence tomography (SD-OCT), and pupil cycle time (PCT). METHODS: This observational, cross-sectional study included 30 patients with unilateral amblyopia and 30 healthy subjects. Optical coherence tomography (OCT) and pupil cycle time (PCT) were used to evaluate patients with unilateral amblyopia and were compared with their non-amblyopic fellow eyes and age- and gender-matched healthy eyes (30 participants)...
November 9, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29113660/functional-hepatic-imaging-as-a-biomarker-of-primary-and-secondary-tumor-response-to-loco-regional-therapies
#17
REVIEW
H L Lewis, M A Ghasabeh, P Khoshpouri, I R Kamel, T M Pawlik
Objective criteria to measure tumor response are a key tenet for assessment of treatment efficacy when evaluating a therapeutic modality. Several response criteria have been proposed including the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST (mRECIST), RECIST 1-1, and European Association for the Study of the Liver (EASL) guidelines. Response following loco-regional therapies (LRT) can be particularly difficult to assess as post-treatment changes may not always relate to changes in lesion size...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29112904/procalcitonin-accurately-predicts-lung-transplant-adults-with-low-risk-of-pulmonary-graft-dysfunction-and-intensive-care-mortality
#18
Cristopher Mazo, Bárbara Borgatta, Teresa Pont, Alberto Sandiumenge, Silvia Moyano, Antonio Roman, Jordi Rello
PURPOSE: We evaluated the association of procalcitonin (PCT), IL-6-8-10 plasma levels during the first 72h after lung transplantation (LT) with ICU-mortality, oxygenation, primary graft dysfunction (PGD), and one-year graft function after LT. MATERIAL AND METHODS: Prospective, observational study. PCT and IL-6-8-10 plasma levels were measured at 24h, 48h and 72h after LT from 100 lung transplant recipients (LTr). Patients were followed until one year after LT. End-points were ICU survival, grade 3 PGD at 72h and one-year graft function...
October 31, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29111402/monitoring-both-procalcitonin-and-c-reactive-protein-in-the-early-period-after-tetralogy-of-fallot-correction-in-children-promotes-rational-antibiotic-use
#19
Radoslaw Jaworski, Ireneusz Haponiuk, Ninela Irga-Jaworska, Mariusz Steffens, Maciej Chojnicki, Konrad Paczkowski, Jacek Zielinski
PURPOSE: This retrospective cohort study aimed to identify the early postoperative kinetics of C-reactive protein (CRP) and procalcitonin (PCT) in children undergoing tetralogy of Fallot (ToF) correction. The ability of these inflammatory markers to guide rational antibiotic usage was also determined. MATERIALS AND METHODS: All consecutive children who underwent ToF correction in 2009-2016 in our referral pediatric cardiac surgery clinic in Gdansk, Poland and did not exhibit infection signs on early postoperative days (POD) were identified...
October 27, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29108401/clinical-value-of-procalcitonin-for-suspected-nosocomial-bloodstream-infection
#20
Joo Kyoung Cha, Ki Hwan Kwon, Seung Joo Byun, Soo Ryeong Ryoo, Jeong Hyeon Lee, Jae-Woo Chung, Hee Jin Huh, Seok Lae Chae, Seong Yeon Park
Background/Aims: Procalcitonin (PCT) may prove to be a useful marker to exclude or predict bloodstream infection (BSI). However, the ability of PCT levels to differentiate BSI from non-BSI episodes has not been evaluated in nosocomial BSI. Methods: We retrospectively reviewed the medical records of patients ≥ 18 years of age with suspected BSI that developed more than 48 hours after admission. Results: Of the 785 included patients, 105 (13...
November 8, 2017: Korean Journal of Internal Medicine
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