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https://www.readbyqxmd.com/read/28210512/porphyria-cutanea-tarda-in-a-patient-with-end-stage-renal-disease-a-case-of-successful-treatment-with-deferoxamine-and-ferric-carboxymaltose
#1
Natacha Rodrigues, Fernando Caeiro, Alice Santana, Teresa Mendes, Leonor Lopes
Porphyria cutanea tarda (PCT) is a rare disease, with a strong association with hepatitis C virus. PCT is particularly problematic in end-stage renal disease patients as they have no renal excretion of porphyrins and these are poorly dialyzed. Also, conventional treatment of PCT is compromised in these patients as hydroxychloroquine is contraindicated, phlebotomies with the stipulated frequency are poorly tolerated in already anaemia-prone patients, and iron-chelating agents are less efficient in removing iron and contribute to worsening anaemia...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/28203255/the-influencing-factors-on-procalcitonin-values-in-newborns-with-noninfectious-conditions-during-the-first-week-of-life
#2
Jueseong Lee, Yong Hyeon Bang, Eun Hee Lee, Byung Min Choi, Young Sook Hong
PURPOSE: Although procalcitonin (PCT) level is useful for the diagnosis of neonatal sepsis, PCT reliability is inconsistent because of the varied conditions encountered in neonatal intensive care units. This study aimed to investigate PCT levels and factors influencing increased PCT levelin newborns without bacterial infection during the first week of life. METHODS: In newborns hospitalized between March 2013 and October 2015, PCT levels were measured on the first, third, and seventh days after birth...
January 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28201980/procalcitonin-for-infections-in-the-first-week-after-pediatric-liver-transplantation
#3
Vladimir L Cousin, Kalinka Lambert, Shahar Trabelsi, Annick Galetto-Lacour, Klara M Posfay-Barbe, Barbara E Wildhaber, Valérie A McLin
BACKGROUND: Procalcitonin (PCT) has become a commonly used serum inflammatory marker. Our aim was to describe the kinetics and usefulness of serial post-operative PCT measurements to detect bacterial infection in a cohort of children immediately after pediatric liver transplantation (pLT). METHODS: We performed a retrospective chart review of a cohort of pLT recipients with serial serum PCT measurements in the first week following pLT. The presence of infection was determined on clinical and biological parameters...
February 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28197044/the-impact-of-early-tracheostomy-in-neurotrauma-patients-a-retrospective-study
#4
Kapil G Zirpe, Deepali Vishnu Tambe, Abhijit M Deshmukh, Sushma K Gurav
BACKGROUND: Although majority of neurotrauma patients require long term ventilatory support but the timing of tracheostomy in such patients is controversial. METHOD: This retrospective study was conducted at a Tertiary Care Hospital, Pune, India. Patients >18 years of age, who underwent percutaneous tracheostomy (PCT) from June 2010 to November 2014 at neurotrauma unit (NTU) of hospital, were included. Patients were divided in two groups according to the timing of tracheostomy, early tracheostomy (ET) group (≤5 days; N=100) and late tracheostomy (LT) group (>5 days; N=64)...
January 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28182347/the-diagnostic-value-of-procalcitonin-versus-other-biomarkers-in-prediction-of-bloodstream-infection
#5
Ya-Ping Pan, Ya-Ping Fang, Yuan-Hong Xu, Zhong-Xin Wang, Ji-Lu Shen
BACKGROUND: We compared the diagnostic utility of procalcitonin (PCT), C-reactive protein (CRP), and hematological markers, including white blood cell count (WBC), neutrophils (NEU), percentage of neutrophils (NEU%), lymphocytes (LYM), neutrophil-lymphocyte count ratio (NLCR), and platelet count (PLT) for predicting bloodstream infection (BSI), which was confirmed by blood culture (BC). METHODS: A retrospective analysis was conducted for 1807 inpatients. The level of PCT, CRP, blood cells, and blood culture results were compared between the positive blood culture group and negative blood culture group; each indicator was analyzed in the performance of bacterial BSI diagnosis by drawing ROC curves...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28179587/profile-of-6-microrna-in-blood-plasma-distinguish-early-stage-alzheimer-s-disease-patients-from-non-demented-subjects
#6
Siranjeevi Nagaraj, Katarzyna Laskowska-Kaszub, Konrad J Dębski, Joanna Wojsiat, Michał Dąbrowski, Tomasz Gabryelewicz, Jacek Kuźnicki, Urszula Wojda
Alzheimer's disease (AD) is the most common age-related dementia. Among its major challenges is identifying molecular signatures characteristic for the early AD stage in patients with Mild Cognitive Impairment (MCI-AD), which could serve for deciphering the AD pathomechanism and also as non-invasive, easy-to-access biomarkers. Using qRT-PCR we compared the microRNA (miRNA) profiles in blood plasma of 15 MCI-AD patients, whose diagnoses were confirmed by cerebrospinal fluid (CSF) biomarkers, with 20 AD patients and 15 non-demented, age-matched individuals (CTR)...
February 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28179405/diagnostic-accuracy-of-cerebrospinal-fluid-procalcitonin-in-bacterial-meningitis-patients-with-empiric-antibiotic-pretreatment
#7
Wen Li, Xiaolong Sun, Fang Yuan, Qiong Gao, Yue Ma, Yongli Jiang, Xiai Yang, Fang Yang, Lei Ma, Wen Jiang
Accurate diagnosis of bacterial meningitis (BM) relies on cerebrospinal fluid (CSF) Gram stain and bacterial culture, which often present high false-negative rates because of the antibiotic abuse. Thus a novel and reliable diagnostic biomarker is highly required. Procalcitonin (PCT) is well demonstrated to be specifically produced from peripheral tissues by bacterial infection, which makes it a potential candidate. Here, we performed a prospective clinical study comprising a total of 143 patients to investigate the diagnostic value of CSF PCT, serum PCT and other conventional biomarkers for BM...
February 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28166929/kinetics-of-plasma-procalcitonin-soluble-cd14-ccl2-and-il-10-after-a-sublethal-infusion-of-lipopolysaccharide-in-horses
#8
Francesca Bonelli, Valentina Meucci, Thomas J Divers, Bettina Wagner, Luigi Intorre, Micaela Sgorbini
Endotoxemia represents a significant clinical and economic problem for the equine industry. This study assesses the kinetics of soluble CD14 (sCD14), chemokine (CC motif) ligand 2 (CCL2), interleukin 10 (IL-10) and plasma procalcitonin (PCT) in healthy horses after the intravenous infusion of lipopolysaccharide (LPS). The aim was to contribute to the basic understanding of the equine species-specific kinetics of these molecules in response to LPS exposure, which could support further findings in clinical studies and identify valuable inflammatory biomarkers for equine practice...
February 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28164563/cell-free-dna-and-procalcitonin-as-early-markers-of-complications-in-icu-patients-with-multiple-trauma-and-major-surgery
#9
Asmaa I Ahmed, Randa A Soliman, Shereif Samir
BACKGROUND: Cell free DNA (cfDNA) was recently suggested as a new marker of sepsis and poor outcome in ICU patients. Procalcitonin has also been the focus of attention as an early marker for systemic inflammation and sepsis. METHODS: cfDNA, procalcitonin (PCT), C-reactive protein (CRP), and lactate levels were measured in 30 ICU patients with multiple trauma or after major surgery on the first day of admission and on 5th and 7th days for PCT, CRP, and lactate. cfDNA was measured by real-time PCR, PCT by ELISA, CRP immunoturbidimetrically, and lactate spectrophotometrically...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28161884/usefulness-of-procalcitonin-in-differentiating-candida-and-bacterial-blood-stream-infections-in-critically-ill-septic-patients-outside-the-intensive-care-unit
#10
Filippo Pieralli, Lorenzo Corbo, Arianna Torrigiani, Dario Mannini, Elisa Antonielli, Antonio Mancini, Francesco Corradi, Fabio Arena, Alberto Moggi Pignone, Alessandro Morettini, Carlo Nozzoli, Gian Maria Rossolini
We aimed to explore the role of procalcitonin (PCT) for the diagnosis of Candida spp. bloodstream infections in a population of critically ill septic patients admitted to internal medicine units. This is a retrospective case-control study considering all cases of candidemia identified in three internal medicine units, from January 1st 2012 to May 31st 2016. For each case of candidemia, two patients with bacteremic sepsis were included in the study as control cases. The end point of the study was to evaluate the diagnostic performance of PCT for the diagnosis of Candida spp...
February 4, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28158976/the-role-of-serum-procalcitonin-in-establishing-the-diagnosis-and-prognosis-of-pleural-infection
#11
Giles Dixon, Adriana Lama-Lopez, Oliver J Bintcliffe, Anna J Morley, Clare E Hooper, Nick A Maskell
BACKGROUND: Bacterial pleural infection requires prompt identification to enable appropriate investigation and treatment. In contrast to commonly used biomarkers such as C-reactive protein (CRP) and white cell count (WCC), which can be raised due to non-infective inflammatory processes, procalcitonin (PCT) has been proposed as a specific biomarker of bacterial infection. The utility of PCT in this role is yet to be validated in a large prospective trial. This study aimed to identify whether serum PCT is superior to CRP and WCC in establishing the diagnosis of bacterial pleural infection...
February 3, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28157725/feasibility-of-training-frontline-therapists-in-prolonged-exposure-a-randomized-controlled-pilot-study-of-treatment-of-complex-trauma-in-diverse-victims-of-crime-and-violence
#12
Bita Ghafoori, Marissa C Hansen, Erika Garibay, Olga Korosteleva
The study aims were to determine whether prolonged exposure (PE) improved mental health and was feasible to implement by frontline clinicians in a culturally diverse sample with complex trauma. Seventy-one individuals were randomly assigned to PE or person-centered therapy (PCT). Outcome measures were administered at baseline and sessions 3, 6, 9, and 12. Mixed modeling was used to regress outcome measures on time, treatment group, and number of visits. Individuals who received PE showed significant moderate association with decline in reported posttraumatic stress disorder (PTSD) symptoms as noted by the PTSD Checklist for DSM-5 (p = 0...
February 3, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28155994/pancreatic-stone-protein-and-soluble-cd25-for-infection-and-sepsis-in-an-emergency-department
#13
Luis García de Guadiana-Romualdo, Mario Berger, Enrique Jiménez-Santos, Sergio Rebollo-Acebes, Roberto Jiménez-Sánchez, Patricia Esteban-Torrella, Ana Hernando-Holgado, Alejandro Ortín-Freire, María Dolores Albaladejo-Otón
BACKGROUND: Infection is a common problem in Emergency Departments (ED) and is associated with high mortality, morbidity and costs. Identifying infection in ED patients can be challenging. Biomarkers can facilitate its diagnosis, enabling an early management and improving outcomes. In the critical care setting, two emerging biomarkers, pancreatic stone protein (PSP) and soluble CD25 (sCD25), have demonstrated to be useful for diagnosis of sepsis. We aimed to assess the diagnostic value of these biomarkers, in comparison to procalcitonin (PCT), for infection and sepsis in an ED population with suspected infection...
February 3, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28153679/evaluating-the-value-of-dynamic-procalcitonin-and-presepsin-measurements-for-patients-with-severe-sepsis
#14
Han Yu, Zhijiang Qi, Chenchen Hang, Yingying Fang, Rui Shao, Chunsheng Li
OBJECTIVE: This study comparatively evaluated the value of dynamic procalcitonin (PCT) and presepsin measurements in assessing therapeutic efficacy and prognosis for patients with severe sepsis. METHODS: Patients with severe sepsis (n=109) were enrolled and divided into survival and non-survival groups based on 90-day survival. PCT and presepsin levels were evaluated on days 1, 3, 5, 7, and 12. Sequential organ failure assessment (SOFA) was calculated. RESULTS: PCT from day 5 onward was weakly to moderately positively correlated with SOFA, whereas presepsin from day 3 onward was positively correlated...
January 22, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28153520/impact-of-a-procalcitonin-based-algorithm-on-the-management-of-adhesion-related-small-bowel-obstruction
#15
C Cossé, C Sabbagh, V Carroni, A Galmiche, L Rebibo, J-M Regimbeau
INTRODUCTION: Adhesion-related small bowel obstruction (ASBO) management is difficult if there are no signs of strangulation or peritonitis when intestinal transit has not been restored. The aim of the present study was to determine the impact of combining a procalcitonin (PCT)-based algorithm with clinical signs on the management of uncomplicated ASBO. METHOD: We performed a pilot, retrospective, single-center "before-after" study. During the "before" period (2007 to 2012), patients with uncomplicated ASBO (n=93, the Gastrografin(®) group) underwent a clinical examination and a Gastrografin(®) index...
January 30, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28151913/factors-predicting-surgical-site-infection-after-posterior-lumbar-surgery-a-multicenter-retrospective-study
#16
Tao Wang, Hui Wang, Da-Long Yang, Li-Qiang Jiang, Li-Jun Zhang, Wen-Yuan Ding
This is a retrospective study.The purpose of this study is to explore incidence and risk factors for surgical site infection (SSI) after posterior lumbar surgery.SSI is a common complication after posterior lumbar surgery, bringing mental and physical pain and prolonging hospital stay. However, predisposing factors, as reported less, remain controversial.Patients who underwent posterior lumbar surgery at 3 centers between 2006 and 2016 were included. The possible factors include 3 aspects: demographic variables-age, sex, body mass index (BMI), waist-to-hip radio (WHR), hypertension, diabetes, heart disease, smoking, drinking, steroidal injection, surgical time between June and September, preoperative shower; blood test variables-white blood cell (WBC), neutrophil, red blood cell (RBC), hemoglobin (Hb), total protein (TP), albumin, albumin/globulin (A/G), C-reactive protein (CRP), procalcitonin (PCT), erythrocyte sedimentation rate (ESR) and surgical related variables-operation time, blood loss, operative level, instrumentation, incision length...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28149576/duration-of-antibiotic-therapy-in-the-intensive-care-unit
#17
REVIEW
Gabor Zilahi, Mary Aisling McMahon, Pedro Povoa, Ignacio Martin-Loeches
There are certain well defined clinical situations where prolonged therapy is beneficial, but prolonged duration of antibiotic therapy is associated with increased resistance, medicalising effects, high costs and adverse drug reactions. The best way to decrease antibiotic duration is both to stop antibiotics when not needed (sterile invasive cultures with clinical improvement), not to start antibiotics when not indicated (treating colonization) and keep the antibiotic course as short as possible. The optimal duration of antimicrobial treatment for ventilator-associated pneumonia (VAP) is unknown, however, there is a growing evidence that reduction in the length of antibiotic courses to 7-8 days can minimize the consequences of antibiotic overuse in critical care, including antibiotic resistance, adverse effects, collateral damage and costs...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28149138/role-of-procalcitonin-in-evaluation-of-the-severity-of-acute-cholecystitis
#18
Yucel Yuzbasioglu, Hikmet Duymaz, Ceren Sen Tanrikulu, Huseyin Cahit Halhalli, Mirac Ozturk Koc, Meral Tandoğan, Figen Coskun
OBJECTIVE: The aim of this study is to investigate the relationship between procalcitonin (PCT) level and the severity of acute cholecystitis. MATERIALS AND METHODS: This study included 200 patients diagnosed with acute cholecystitis. To diagnose and assess the severity of acute cholecystitis; physical examination and abdominal ultrasound findings were evaluated and blood samples were taken to determine white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and levels of coagulation factors, blood gas, C-reactive protein (CRP) and PCT...
October 2016: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28138311/specific-networks-of-plasma-acute-phase-reactants-are-associated-with-the-severity-of-chronic-obstructive-pulmonary-disease-a-case-control-study
#19
Elena Arellano-Orden, Carmen Calero-Acuña, Juan Antonio Cordero, María Abad-Arranz, Verónica Sánchez-López, Eduardo Márquez-Martín, Francisco Ortega-Ruiz, José Luis López-Campos
Objectives. A detailed understanding of the intricate relationships between different acute phase reactants (APRs) in chronic obstructive pulmonary disease (COPD) can shed new light on its clinical course. In this case-control study, we sought to identify the interaction networks of a number of plasma APRs in COPD, with a special focus on their association with disease severity. Methods. COPD cases and healthy smoking controls (3:1 ratio) were recruited in our outpatient pulmonary clinic. Cardiopulmonary exercise testing was used to rule out the presence of ischemic heart disease...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28135842/annals-express-diagnostic-accuracy-of-lipopolysaccharide-binding-protein-for-sepsis-in-patients-with-suspected-infection-in-the-emergency-department
#20
Luis García de Guadiana Romualdo, María Dolores Albaladejo Otón, Sergio Rebollo Acebes, Patricia Esteban Torrella, Ana Hernando-Holgado, Enrique Jiménez Santos, Roberto Jiménez Sánchez, Alejandro Ortín Freire
BACKGROUND: Biomarkers can facilitate the diagnosis of sepsis, enabling early management and improving outcomes. Lipopolysaccharide binding protein (LBP) has been reported as a biomarker for detection of infection, but its diagnostic value is controversial. In this study, we assessed the diagnostic accuracy of LBP for sepsis in emergency department (ED) patients, comparing it with more established biomarkers of sepsis, including procalcitonin (PCT) and C-reactive protein (CRP). METHODS: LBP and other sepsis biomarkers, including PCT and CRP, were measured on admission in 102 adult patients presenting with suspected infection...
January 1, 2017: Annals of Clinical Biochemistry
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