Gui-Shan Xiao, Yu-Sheng Jin, Qing-Yi Lu, Zuo-Feng Zhang, Arie Belldegrun, Robert Figlin, Allan Pantuck, Yun Yen, Frederick Li, Jianyu Rao
Using a multistep human urothelial model, we previously showed that green tea extract (GTE) selectively modulates actin remodeling in transformed cells (MC-T11), which resulted in increased cell adhesion and reduced cell motility (Lu et al., Clin Cancer Res 2005;11:1675-83). This study further analyzed which actin binding proteins (ABPs) might be involved in this process. Proteomic profiles of GTE treated and untreated MC-T11 cells using two-dimensional gel electrophoresis coupled with liquid chromatography tandem mass spectrometry (LC/MS/MS) and matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) identified 20 GTE-induced proteins...
January 1, 2007: International Journal of Cancer. Journal International du Cancer