Murielle P Serres, Ronan Shaughnessy, Sophie Escot, Hussein Hammich, Frédérique Cuvelier, Audrey Salles, Murielle Rocancourt, Quentin Verdon, Anne-Lise Gaffuri, Yannick Sourigues, Gilles Malherbe, Leonid Velikovsky, Florian Chardon, Nathalie Sassoon, Jean-Yves Tinevez, Isabelle Callebaut, Etienne Formstecher, Anne Houdusse, Nicolas B David, Olena Pylypenko, Arnaud Echard
Cilia protrude from the cell surface and play critical roles in intracellular signaling, environmental sensing, and development. Reduced actin-dependent contractility and intracellular trafficking are both required for ciliogenesis, but little is known about how these processes are coordinated. Here, we identified a Rac1- and Rab35-binding protein with a truncated BAR (Bin/amphiphysin/Rvs) domain that we named MiniBAR (also known as KIAA0355/GARRE1), which plays a key role in ciliogenesis. MiniBAR colocalizes with Rac1 and Rab35 at the plasma membrane and on intracellular vesicles trafficking to the ciliary base and exhibits fast pulses at the ciliary membrane...
October 20, 2023: Developmental Cell