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diabetic ketoacidosis diagnosis

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https://www.readbyqxmd.com/read/29666080/eye-for-an-eye-near-fatal-outcome-of-fungal-infection-in-a-young-diabetic-girl
#1
Fedja I Vos, Sietze Reitsma, Gwijde F J P M Adriaensen, Wytske J Fokkens
In this report, we describe the case of a young, diabetic girl with ketoacidosis who suffered sudden loss of vision of the right eye. The loss of vision was caused by an invasive rhino-orbital-cerebral fungal infection (mucormycosis) with extensive periorbital thrombosis. Despite maximal antifungal and surgical treatment (including exenteration of the right orbit), the clinical situation deteriorated. It was only after overcoming the difficulties of managing her hyperglycaemia that the patient's condition stabilised and her life was saved...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29643888/spectrum-of-complications-of-severe-dka-in-children-in-pediatric-intensive-care-unit
#2
Qalab Abbas, Saba Arbab, Anwar Ul Haque, Khadija Nuzhat Humayun
Objectives: To describe the spectrum of complications of Diabetic Ketoacidosis (DKA) observed in children admitted with severe DKA. Methods: Retrospective review of the medical records of all children admitted with the diagnosis of severe DKA in Pediatric Intensive Care Unit (PICU) of the Aga Khan University Hospital, from January 2010 to December 2015 was done. Data was collected on a structured proforma and descriptive statistics were applied. Results: Total 37 children were admitted with complicated DKA (1...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29624095/external-validation-of-the-diabetes-early-readmission-risk-indicator-derri-%C3%A2
#3
Daniel J Rubin, Dominic Recco, Alexander Turchin, Huaqing Zhao, Sherita Hill Golden
OBJECTIVE: The Diabetes Early Readmission Risk Indicator (DERRI™ ) was previously developed and internally validated as a tool to predict the risk of all-cause readmission within 30 days of discharge (30-d readmission) of hospitalized patients with diabetes. In this study, the predictive performance of the DERRI™ with and without additional predictors was assessed in an external sample. METHODS: We conducted a retrospective cohort study of adult patients with diabetes discharged from 2 academic medical centers between 1/1/2000 and 12/31/2014...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29622578/relationship-between-islet-autoantibody-status-and-the-clinical-characteristics-of-children-and-adults-with-incident-type-1-diabetes-in-a-uk-cohort
#4
Vassiliki Bravis, Akaal Kaur, Helen C Walkey, Ian F Godsland, Shivani Misra, Polly J Bingley, Alistair J K Williams, David B Dunger, Colin M Dayan, Mark Peakman, Nick S Oliver, Desmond G Johnston
OBJECTIVES: To describe the characteristics of children and adults with incident type 1 diabetes in contemporary, multiethnic UK, focusing on differences between the islet autoantibody negative and positive. DESIGN: Observational cohort study. SETTING: 146 mainly secondary care centres across England and Wales. PARTICIPANTS: 3312 people aged ≥5 years were recruited within 6 months of a clinical diagnosis of type 1 diabetes via the National Institute for Health Research Clinical Research Network...
April 4, 2018: BMJ Open
https://www.readbyqxmd.com/read/29600548/acute-invasive-fungal-rhinosinusitis-in-twenty-one-diabetic-patients
#5
Pei-Wen Wu, Yen-Lin Huang, Shih-Wei Yang, Yun-Shien Lee, Chi-Che Huang, Po-Hung Chang, Chien-Chia Huang, Ta-Jen Lee
Acute invasive fungal rhinosinusitis (AIFR) is a potentially life-threatening condition, typically occurring in patients with some degree of immunosuppression. Initial presenting symptoms of AIFR are usually nonspecific, and may be interpreted as viral/bacterial rhinosinusitis. In this study, we found diabetic patients with AIFR had better survival rates, compared to previously published case series. This is likely due to the potential reversibility of this predisposing medical disorder with prompt reversal of ketoacidosis and aggressive control of hyperglycemia...
March 30, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29600506/prediabetes-directly-deteriorates-into-diabetic-ketoacidosis-and-hyperosmolar-hyperglycemic-syndrome-triggered-by-acute-pancreatitis-a-case-report-illustrating-a-chicken-and-egg-paradigm-in-ketosis-prone-diabetes
#6
Runbo Song, Shanjin Cao
INTRODUCTION: Diabetic crises occur most often in patients with type 1 diabetes and occasionally in type 2 diabetes, especially under stressful conditions. However, a diabetic crisis occurring directly from prediabetes is an unusual phenomenon. CASE REPORT: A 45-year-old woman presented with postprandial left upper quadrant abdominal pain, nausea, and vomiting. She had a past medical history of prediabetes with impaired fasting glucose and HbA1c 6.4%. On admission, routine laboratory tests showed high anion gap metabolic acidosis (pH 6...
March 29, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29575401/previously-undiagnosed-attention-deficit-hyperactivity-disorder-associated-with-poor-metabolic-control-in-adolescents-with-type-1-diabetes
#7
C Nylander, K Lindström, N Khalifa, E Fernell
BACKGROUND: Managing modern diabetes treatment requires efficient executive functions. Patients with attention-deficit/hyperactivity disorder (ADHD) and type 1 diabetes have poor metabolic control and present with ketoacidosis more often than patients without ADHD. OBJECTIVE: To assess whether patients with type 1 diabetes and with indications of executive problems met criteria for ADHD, and to investigate whether these patients had difficulties achieving metabolic control...
March 24, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29568778/integration-of-routine-parameters-of-glycemic-variability-in-a-simple-screening-method-for-partial-remission-in-children-with-type-1-diabetes
#8
Nina Nielens, Olivier Pollé, Annie Robert, Philippe A Lysy
Although different criteria were used to define partial remission in type 1 diabetes, the IDAA1C formula has prevailed as it correlates with stimulated C-peptide levels. Our retrospective study evaluated clinical variables associated with the occurrence of IDAA1C-defined partial remission in a series of 239 pediatric patients. Diabetic ketoacidosis and age at diagnosis, but no other clinical feature, influenced the occurrence of remission. We then evaluated whether parameters of glycemic variability used in clinical routine may reliably define partial remission, as these would alleviate confounding factors related to insulin treatment...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29559955/understanding-pre-type-1-diabetes-the-key-to-prevention
#9
REVIEW
Laura M Jacobsen, Michael J Haller, Desmond A Schatz
While the incidence of type 1 diabetes continues to rise by 3% each year, the ability to prevent this disease remains elusive. Hybrid closed loop devices, artificial pancreas systems, and continuous glucose monitoring technology have helped to ease the daily burden for many people living with type 1 diabetes. However, the artificial pancreas is not a cure; more research is needed to achieve our ultimate goal of preventing type 1 diabetes. The preceding decades have generated a wealth of information regarding the natural history of pre-type 1 diabetes...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29559408/review-of-hyperglycaemia-definitions-and-pathophysiology
#10
Gaëlle Cheisson, Sophie Jacqueminet, Emmanuel Cosson, Carole Ichai, Anne-Marie Leguerrier, Bogdan Nicolescu-Catargi, Alexandre Ouattara, Igor Tauveron, Paul Valensi, Dan Benhamou
Diabetes mellitus is defined by chronic elevation of blood glucose linked to insulin resistance and/or insulinopaenia. Its diagnosis is based on a fasting blood-glucose level of ≥1.26g/L or, in some countries, a blood glycated haemoglobin (HbA1c) level of >6.5%. Of the several forms of diabetes, type-2 diabetes (T2D) is the most common and is found in patients with other risk factors. In contrast, type-1 diabetes (T1D) is linked to the auto-immune destruction of β-pancreatic cells, leading to insulinopaenia...
March 17, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29548694/opportunities-for-earlier-diagnosis-of-type-1-diabetes-in-children-a-case-control-study-using-routinely-collected-primary-care-records
#11
Joseph Jonathan Lee, Matthew James Thompson, Juliet Alexandra Usher-Smith, Constantinos Koshiaris, Ann Van den Bruel
BACKGROUND: The epidemiology of type 1 diabetes mellitus (T1DM) suggests diagnostic delays may contribute to children developing diabetic ketoacidosis at diagnosis. We sought to quantify opportunities for earlier diagnosis of T1DM in primary care. METHODS: A matched case-control study of children (0-16 years) presenting to UK primary care, examining routinely collected primary care consultation types and National Institute for Health and Care Excellence (NICE) warning signs in the 13 weeks before diagnosis...
March 13, 2018: Primary Care Diabetes
https://www.readbyqxmd.com/read/29544233/-diabetic-ketoacidosis-and-hyperosmolar-hyperglycemic-state
#12
Christina Schumann, Michael Faust
BACKGROUND:  Diabetic ketoacidosis and the hyperosmolar hyperglycemic state are the most serious diabetic emergencies. Before the discovery of insulin in 1921 by Banting and Best the diagnosis of type 1 diabetes was fatal ending in diabetic ketoacidosis equivalent to a torturous death. Today, mortality from diabetic ketoacidosis is low at approximately 2 %. But each death from these two acute metabolic complications of diabetes is potentially avoidable by improved patient and healthcare professional education...
March 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29537213/prevalence-and-clinical-presentation-at-the-onset-of-type-1-diabetes-mellitus-among-children-and-adolescents-in-al-baha-region-saudi-arabia
#13
Ahmed Hassan Al-Ghamdi, Abdelhameed Ahmed Fureeh
BACKGROUND: The objectives were to describe the frequency of clinical presentation at the onset of type 1 diabetes mellitus (T1DM) and to estimate the prevalence of T1DM among children and adolescents in the AL-Baha region, Saudi Arabia, aiming for early diagnosis of T1DM. METHODS: The clinical and laboratory data of 471 children and adolescents who presented with T1DM and received medical care at an AL-Baha diabetic center during the period from 2007 to 2016 were retrospectively analyzed based on the records...
March 28, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29527255/glycogenic-hepatopathy-a-narrative-review
#14
REVIEW
Jagannath M Sherigar, Joline De Castro, Yong Mei Yin, Debra Guss, Smruti R Mohanty
Glycogenic hepatopathy (GH) is a rare complication of the poorly controlled diabetes mellitus characterized by the transient liver dysfunction with elevated liver enzymes and associated hepatomegaly caused by the reversible accumulation of excess glycogen in the hepatocytes. It is predominantly seen in patients with longstanding type 1 diabetes mellitus and rarely reported in association with type 2 diabetes mellitus. Although it was first observed in the pediatric population, since then, it has been reported in adolescents and adults with or without ketoacidosis...
February 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29526940/emphysematous-osteomyelitis-of-the-spine-a-case-report-and-literature-review
#15
Ryohei Ono, Koji Uehara, Izumi Kitagawa
Emphysematous osteomyelitis is a rare but potentially fatal infection. It is caused by gas-forming organismsand is characterized by the presence of intraosseous gas. A 75-year-old woman with untreated diabetes mellitus presented with difficulty in moving and anorexia. Laboratory studies revealed inflammation, a urinary infection, and diabetic ketoacidosis. Klebsiella pneumoniae was detected in both urine and blood cultures. Computed tomography and magnetic resonance imaging revealed emphysematous lesions in the paravertebral soft tissue, spinal canal, and iliopsoas muscle, with intraosseous gas at L1 and L2...
March 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29523007/incidence-of-diabetic-ketoacidosis-of-new-onset-type-1-diabetes-in-children-and-adolescents-in-different-countries-correlates-with-human-development-index-hdi-an-updated-systematic-review-meta-analysis-and-meta-regression
#16
Johann Große, Henriette Hornstein, Ulf Manuwald, Joachim Kugler, Ingmar Glauche, Ulrike Rothe
Type 1 diabetes mellitus (T1DM) is usually diagnosed by insulin deficiency at a young age. Diabetic ketoacidosis (DKA) represents a severe complication occurring before the first diagnosis of T1DM. Actually, the data situation is still unsettled in assessing the current state of diagnosis. This study summarizes the latest rates of DKA of new-onset T1DM in children and adolescents in different countries available over the last five years. Different T1DM-related, geographical and socioeconomic moderators are suitable to explain the heterogeneity of observed DKA rates...
March 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29518369/clinical-features-and-prognosis-of-type-ii-myocardial-infarction-in-acutely-decompensated-diabetes-patients
#17
AbdulWahab Hritani, M Fuad Jan, Gregory Schleis, Tara Zehrer, Susan Olet, Khawaja Afzal Ammar, Suhail Allaqaband
BACKGROUND: After the introduction of the universal definition of myocardial infarction, the incidence and diagnosis of type 2 myocardial infarction have risen dramatically, yet there are no clear guidelines on clinical management. Diabetic patients are at high risk for developing type 2 myocardial infarction when admitted in a decompensated state and they are also at high risk for future cardiovascular events. METHODS: We performed a retrospective analysis of 1058 patients between 2011 and 2016 admitted with diabetic ketoacidosis or hyperosmolar hyperglycemic state...
March 5, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29513157/use-of-lispro-insulin-for-treatment-of-diabetic-ketoacidosis-in-cats
#18
Eleonora Malerba, Michela Mazzarino, Francesca Del Baldo, Sara Corradini, Gaia Carotenuto, Massimo Giunti, Federico Fracassi
Objectives The aim of this study was to evaluate the efficacy and safety of lispro insulin for the treatment of feline diabetic ketoacidosis (DKA). Times to resolution of hyperglycaemia, ketosis and acidosis were compared between cats treated with continuous rate infusion (CRI) of lispro insulin and cats treated with CRI of regular insulin. Methods Client-owned cats with naturally occurring DKA, newly diagnosed with diabetes mellitus (DM) or already receiving treatment for DM, were included. Diagnosis of DKA involved the presence of at least two clinical signs consistent with DKA (eg, polyuria/polydipsia, anorexia, severe lethargy, vomiting and dehydration), blood glucose (BG) concentration >13...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29500601/clinical-study-of-pregnancy-associated-fulminant-type-1-diabetes
#19
Lan Liu, Wenjuan Jia, Ruike Liu, Jie Shen
BACKGROUND: Studies reported that fulminant type 1 diabetes (fT1DM) can occurred during pregnancy or within 2 weeks after delivery, and was defined as pregnancy-associated fulminant type 1 diabetes (PF). In PF patients, plasma glucose (PG) levels have an abrupt rise while glycated hemoglobin (HbA1C ) levels are not markedly elevated, resulting in a sharply increased PG/HbA1C ratio. METHODS: We studied 30 PF patients, 21 non-pregnant fulminant type 1 diabetes (NPF) patients, and 26 female patients of child-bearing age (13-49 years) with diabetic ketoacidosis (DKA), all from China...
March 2, 2018: Endocrine
https://www.readbyqxmd.com/read/29496742/racial-ethnic-minority-youth-with-recent-onset-type-1-diabetes-have-poor-prognostic-factors
#20
Maria Jose Redondo, Ingrid Libman, Peiyao Cheng, Craig Kollman, Mustafa Tosur, Robin L Gal, Fida Bacha, Georgeanna J Klingensmith, Mark Clements
OBJECTIVE: To compare races/ethnicities for characteristics, at type 1 diabetes diagnosis and during the first 3 years postdiagnosis, known to influence long-term health outcomes. RESEARCH DESIGN AND METHODS: We analyzed 927 Pediatric Diabetes Consortium (PDC) participants <19 years old (631 non-Hispanic white [NHW], 216 Hispanic, and 80 African American [AA]) diagnosed with type 1 diabetes and followed for a median of 3.0 years (interquartile range 2.2-3.6)...
March 1, 2018: Diabetes Care
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