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childhood hypertension

Shao-Hua Xie, Jesper Lagergren
The Chinese famine in 1958-1962 was one of the worst in human history, but its potential influence on cancer risks is uncertain. Using cancer incidence data in Shanghai, China, during 1983-2007, we calculated age-specific incidence rates of gastrointestinal cancers in birth cohorts exposed to the Chinese famine in different periods of life and a non-exposed reference cohort. Age-period-cohort regressions estimated the overall relative risks of gastrointestinal cancers in each birth cohort. A total of 212,098 new cases of gastrointestinal cancer were identified during the study period (129,233 males and 82,865 females), among whom 18,146 had esophageal cancer, 71,011 gastric cancer, 55,864 colorectal cancer, 42,751 liver cancer, 9,382 gallbladder cancer, and 14,944 had pancreatic cancer...
October 25, 2016: International Journal of Cancer. Journal International du Cancer
Susan Bromley, David Vizcaya
Childhood interstitial lung disease (chILD) comprises a wide heterogeneous group of rare parenchymal lung disorders associated with substantial morbidity and mortality. Pulmonary hypertension is a common comorbidity in adults with interstitial lung disease (ILD) and associated with poor survival. We aimed to systematically review the literature regarding the occurrence of pulmonary hypertension (PH) in chILD, its effect on prognosis and healthcare use, and its treatment in clinical practice. Searches of PubMed and EMBASE databases (up to February 2016), and American Thoracic Society conference abstracts (2009-2015) were conducted using relevant keywords...
October 23, 2016: Pediatric Pulmonology
Gizem Dilan Yesil, Olta Gishti, Janine F Felix, Irwin Reiss, Mohammad Kamran Ikram, Eric A P Steegers, Albert Hofman, Vincent W V Jaddoe, Romy Gaillard
Gestational hypertensive disorders may lead to vascular changes in the offspring. We examined the associations of maternal blood pressure development and hypertensive disorders during pregnancy with microvasculature adaptations in the offspring in childhood. This study was performed as part of the Generation R Study in Rotterdam, the Netherlands (2002-2012), among 3,748 pregnant mothers and their children for whom information was available on maternal blood pressure in different periods of pregnancy and gestational hypertensive disorders...
October 17, 2016: American Journal of Epidemiology
Peter Nilsson
A number of chronic disease conditions tend to cluster in families with an increased risk in first-degree relatives, but also an increased risk in second-degree relatives. This fact is most often referred to as the heritability (heredity) of these diseases and explained by the influence of genetic factors, or shared environment, even if the more specific details or mechanism leading to disease are not known. New methods have to be explored in screening studies and register linkage studies to define and measure consequences of a positive family history of disease...
September 2016: Journal of Hypertension
Midori Awazu
ABP is more reliable and reproducible than casual BP, enables computation of the mean, daytime, night-time ABP, and 24-h pulse pressure, detects white coat effect or reversed white coat effect, and provides information regarding diurnal BP pattern as well as BP variability. ABP correlates better with target-organ damage than casual BP. ABPM is now widely used also in children. Increasing age and higher mean BP are factors that improve the success rate of ABPM. There is a guideline from American Heart Association to standardize the use of ABPM in children, including the detailed recommendations for the use of ABPM and for the interpretation of the data...
September 2016: Journal of Hypertension
Hui Fan, Yingkun Yan, HongBo Dong, Jie Mi
OBJECTIVE: It was recommended that the diagnosis of hypertension among children should be established on at least three separate occasions. However, the national prevalence of hypertension after three separate occasions was scant in China. The goal of our study was to determine the prevalence of hypertension on up to three separate visits in a Chinese pediatric population, and examined the association between hypertension and weight status. DESIGN AND METHOD: Data were obtained from a national representative sample of 43304 children aged 6-17 years...
September 2016: Journal of Hypertension
Abdullah Mamun
OBJECTIVE: The objectives of this study are to investigate the developmental stages of hypertension between males and females and identify why young males have higher blood pressure than young females. DESIGN AND METHOD: The study used a sub-sample of 2000 offspring from the original cohort of the Mater University of Queensland Study of Pregnancy (MUSP) and its outcomes. The MUSP is a prospective birth cohort study which commenced in early 1980 s in Brisbane, Australia and followed their offspring till young adulthood...
September 2016: Journal of Hypertension
Jianjun Mu, Chao Chu, Dan Wang, Tongshuai Guo, Yang Wang, Fan Yang
OBJECTIVE: To explore the relationship between childhood risk factors and long-term arterial stiffness. DESIGN AND METHOD: A baseline survey was carried out in 4623 school children aged 6-15 years in rural areas of Hanzhong city, Shaanxi in 1987. According to three measurements of systolic blood pressure (SBP) in 1987,1989 and 1992, high blood pressure group (HBP group) was defined as SBP ≥ 75 percentile at same age and gender, with SBP < 50 percentile as normal blood pressure group (NBP group)...
September 2016: Journal of Hypertension
Peter Nilsson
During more than 50 years the high cardiovascular risk in Eastern Europe and former Soviet Union, now Russia, has been described as very high. This is based on epidemiological findings from countries and regions, for example within the MONICA study as organized by the WHO. One common explanation is that this is influenced by an adverse cardiovascular risk factor profile including high prevalence rates of hypertension in many subjects, in combination with unhealthy lifestyle (smoking, alcohol, diet) and stressful social conditions, including health care gaps...
September 2016: Journal of Hypertension
Marko Šimunović, Joško Božić, Lukrecija Milić, Ivana Unić, Veselin Škrabić
Obesity and metabolic syndrome (MS) are one of the biggest public health issues in child and adolescent population. To the best of the authors' knowledge, this hospital based study is the first report on the prevalence of MS in obese children and adolescents in Dalmatia, the Mediterranean part of Croatia. The objectives of this study were to determine the prevalence of individual cardiovascular risk factors and MS. Between January 2009 and June 2014, 201 obese subjects aged 6 to 18 were analyzed retrospectively from our Pediatric Endocrine Unit database...
2016: International Journal of Endocrinology
Saul Castaneda, Esbeydy Garcia, Hermelinda De la Cruz, Oscar Ramirez, Samuel Melendez, Jose Sanchez-Palacio
BACKGROUND: Infantile hemangiomas are the most common childhood vascular tumors, occurring in 10 % of children aged less than 1 year. Propranolol, a β-adrenergic blocker mainly indicated for hypertension, has proven effective in treating these types of tumors. OBJECTIVE: To evaluate the efficacy and adverse effects of propranolol in Mexican pediatric patients diagnosed with infantile hemangioma, treated with an extemporaneously compounded solution of propranolol...
March 2016: Drugs—Real World Outcomes
Agnes Trautmann, Derek J Roebuck, Clare A McLaren, Eileen Brennan, Stephen D Marks, Kjell Tullus
OBJECTIVES: Renovascular disease (RVD) is found in about 10 % of secondary childhood hypertension. Digital subtraction angiography (DSA) is the gold standard to diagnose RVD. Non-invasive imaging methods like Doppler ultrasound (US), magnetic resonance angiography (MRA), and computed tomography angiography (CTA) are increasingly used. Our aim was to evaluate the role and accuracy of US, MRA, and CTA compared to DSA in diagnosing RVD in children. PATIENTS AND METHODS: A retrospective review of 127 children with suspected renovascular hypertension was performed in children referred to Great Ormond Street Hospital between 2006 and 2014 due to clinical suspicion of renovascular hypertension and/or findings on US and/or MRA or CTA...
October 17, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Odaro Huckstep, Adam J Lewandowski, Paul Leeson
Human clinical studies as well as laboratory animal studies demonstrate that offspring of pregnancies affected by common complications, such as preeclampsia and preterm birth, display developmental phenotypes that relate distinctly to the pregnancy disorder. Several studies have now found microvascular differences in offspring of hypertensive pregnancies, and there is interest in whether these may underlie epidemiologic associations between gestational hypertension and a higher risk of hypertension and stroke in the offspring...
October 15, 2016: American Journal of Epidemiology
Kozeta Miliku, Nienke E Bergen, Hanneke Bakker, Albert Hofman, Eric A P Steegers, Romy Gaillard, Vincent W V Jaddoe
BACKGROUND: Hypertensive disorders in pregnancy may affect the cardiovascular risk of offspring. We examined the associations of maternal blood pressure throughout pregnancy and hypertensive disorders in pregnancy with childhood blood pressure of offspring. Specific focus was on the comparison with paternal blood pressure effects, the identification of critical periods, and the role of birth outcomes and childhood body mass index in the observed associations. METHODS AND RESULTS: This study was embedded in a population-based prospective cohort study among 5310 mothers and fathers and their children...
October 14, 2016: Journal of the American Heart Association
Malgorzata Kolpa, Agnieszka Jankowicz-Szymanska, Beata Jurkiewicz
BACKGROUND: Childhood overweight and obesity are common causes of metabolic disorders that persist until adulthood. OBJECTIVES: The purpose of this study was to determine the prevalence of high-normal arterial blood pressure (ABP) in children with excess body weight. MATERIAL AND METHODS: A total of 1,093 schoolchildren aged 10 - 12 years (51% girls and 49% boys) participated in the study. The children's weight, height, body fat percentage (BFP), waist and hip circumference, and ABP were measured...
August 2016: Iranian Journal of Pediatrics
Adebukola B Ajite, Theophilus A Aladekomo, Temilade Aderounmu, Wasiu A Olowu
BACKGROUND: Childhood hypertension has been associated with target-organ damage in young adults. It is often asymptomatic in both children and adolescents; when persistent, and long-standing, it could be a significant risk factor for kidney damage and increased glomerular permeability. OBJECTIVES: Burden of hypertension and its impact on glomerular permeability were prospectively determined in randomly recruited primary school children. PATIENTS AND METHODS: Blood pressure (BP) measurement was performed by the auscultation method, and abnormal glomerular permeability was assessed by dipstick testing of urine for persistent proteinuria and/or hematuria for ≥ three months in hypertensive children...
July 2016: Nephro-urology Monthly
Carmen Piernas, Dantong Wang, Shufa Du, Bing Zhang, Zhihong Wang, Chang Su, Barry M Popkin
BACKGROUND AND OBJECTIVES: China's nutrition transition is characterized by dramatic increases in overweight and cardiometabolic (CM) risk. The burden of obesity, CM risk factors and dietary intake among Chinese children were explored. METHODS AND STUDY DESIGN: Children 7-12 y old from the 2009 China Health and Nutrition Survey with available dietary intake data, anthropometry, blood pressure, and fasting blood samples were included (n=663). CM risk prevalence was calculated; logistic regression was used to investigate the association of nutrient intakes with CM risk, adjusting for age, gender, physical activity, area of residence and income...
December 2016: Asia Pacific Journal of Clinical Nutrition
Enas A Hamed, Mostafa M El-Saied, Khaled Saad, Hazem Abu-Zeid Yousef, Amany O Mohamed, Dina Sabry
OBJECTIVE: This study aimed to evaluate fibrosis and elastin destruction in childhood interstitial lung disease (chILD) patients. METHODS: Sixty patients and twenty healthy children were recruited. On admission, evaluation of chILD severity was made using Fan chILD score. Participants provided urine and blood samples. Plasma levels of transforming growth factor (TGF)-β1, connective tissue growth factor (CCN2), soluble factor related apoptosis (sFas) and long non-coding RNAs and urinary levels of desmosine/urinary creatinine (UDes/UCr) were measured...
September 21, 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Anthe S Sterkenburg, Anika Hoffmann, Julia Reichel, Kristin Lohle, Maria Eveslage, Monika Warmuth-Metz, Hermann L Müller
CONTEXT: Hypothalamic obesity, cardiovascular disease (CVD), and relapse/progression have major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging (MRI) performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP. OBJECTIVE: Identify association of NST with body mass index (BMI), waist-to-height ratio (WHtR), functional capacity, and blood pressure (BP) in CP and controls...
September 28, 2016: Journal of Clinical Endocrinology and Metabolism
Mathilde Chevignard, Leila Francillette, Hanna Toure, Dominique Brugel, Philippe Meyer, Anne Laurent Vannier, Marion Opatowski, Laurence Watier
OBJECTIVE: Childhood traumatic brain injury (TBI) is a leading cause of death and lifelong acquired disability. The aim of this study was to prospectively study intellectual ability following childhood severe TBI over 7-8years post-injury, and factors influencing outcome and change over time. MATERIAL/PATIENTS AND METHODS: Children (0-15years) consecutively admitted in a single trauma center for severe non-inflicted TBI over a 3-year period were included in a prospective longitudinal study...
September 2016: Annals of Physical and Rehabilitation Medicine
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