keyword
https://read.qxmd.com/read/38410438/blood-based-dna-methylation-and-exposure-risk-scores-predict-ptsd-with-high-accuracy-in-military-and-civilian-cohorts
#1
Agaz Wani, Seyma Katrinli, Xiang Zhao, Nikolaos Daskalakis, Anthony Zannas, Allison Aiello, Dewleen Baker, Marco Boks, Leslie Brick, Chia-Yen Chen, Shareefa Dalvie, Catherine Fortier, Elbert Geuze, Jasmeet Hayes, Ronald Kessler, Anthony King, Nastassja Koen, Israel Liberzon, Adriana Lori, Jurjen Luykx, Adam Maihofer, William Milberg, Mark Miller, Mary Mufford, Nicole Nugent, Sheila Rauch, Kerry Ressler, Victoria Risbrough, Bart Rutten, Dan Stein, Murrary Stein, Robert Ursano, Mieke Verfaellie, Erin Ware, Derek Wildman, Erika Wolf, Caroline Nievergelt, Mark Logue, Alicia Smith, Monica Uddin, Eric Vermetten, Christiaan Vinkers
Background Incorporating genomic data into risk prediction has become an increasingly useful approach for rapid identification of individuals most at risk for complex disorders such as PTSD. Our goal was to develop and validate Methylation Risk Scores (MRS) using machine learning to distinguish individuals who have PTSD from those who do not. Methods Elastic Net was used to develop three risk score models using a discovery dataset (n = 1226; 314 cases, 912 controls) comprised of 5 diverse cohorts with available blood-derived DNA methylation (DNAm) measured on the Illumina Epic BeadChip...
February 15, 2024: Research Square
https://read.qxmd.com/read/38408306/association-of-mild-traumatic-brain-injury-post-traumatic-stress-disorder-and-other-comorbidities-on-photosensitivity
#2
JOURNAL ARTICLE
Jenalyn M Jotie, Jennifer A Gustafson, Jennifer R Fonda, Catherine B Fortier, William P Milberg, Francesca C Fortenbaugh
SIGNIFICANCE: Photosensitivity is common after mild traumatic brain injury. However, this study demonstrates that photosensitivity is also impacted by common comorbidities that often occur with mild traumatic brain injury. Understanding how physical and psychological traumas impact photosensitivity can help improve provider care to trauma survivors and guide novel therapeutic interventions. PURPOSE: This study aimed to characterize the association between mild traumatic brain injury and common comorbidities on photosensitivity in post-9/11 veterans...
February 1, 2024: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://read.qxmd.com/read/38014547/importance-of-validity-testing-in-psychiatric-assessment-evidence-from-a-sample-of-multimorbid-post-9-11-veterans
#3
JOURNAL ARTICLE
Sahra Kim, Alyssa Currao, Emma Brown, William P Milberg, Catherine B Fortier
OBJECTIVE: Performance validity (PVTs) and symptom validity tests (SVTs) are necessary components of neuropsychological testing to identify suboptimal performances and response bias that may impact diagnosis and treatment. The current study examined the clinical and functional characteristics of veterans who failed PVTs and the relationship between PVT and SVT failures. METHOD: Five hundred and sixteen post-9/11 veterans participated in clinical interviews, neuropsychological testing, and several validity measures...
November 28, 2023: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/37889391/developing-workforce-skills-and-capacity-in-telehealth-what-lend-trainees-need-to-know
#4
JOURNAL ARTICLE
Michael Bray, Jane Turner, Sean Jones, Tazia Miah, Sharon Milberger
INTRODUCTION: The COVID-19 pandemic significantly impacted the way health-related services are delivered, rapidly shifting from in-person to telehealth visits. To ensure that future healthcare providers are fully prepared to deliver services to families of youth with neurodevelopmental disabilities (NDD), understanding telehealth's advantages and barriers is vital. To this end, data were gathered to inform the development of a nationally available telehealth curriculum aimed at training future healthcare professionals from the Leadership Education in Neurodevelopmental Disabilities (LEND) network...
October 27, 2023: Maternal and Child Health Journal
https://read.qxmd.com/read/37807254/a-124-the-impact-of-attention-deficit-hyperactivity-disorder-adhd-on-cognition-and-function-in-post-9-11-veterans-with-post-traumatic-stress-disorder-ptsd
#5
JOURNAL ARTICLE
Arielle Knight, Sahra Kim, Alyssa Currao, Caroline Sablone, William Milberg, Catherine Fortier
OBJECTIVE: The study examines the impact of ADHD on cognitive and functional abilities in post-9/11 Veterans with PTSD. METHOD: 313 Veterans from the Translational Research Center for TBI and Stress Disorders at VA Boston with PTSD only (44.73%), with ADHD only (3.51%), with both PTSD+ADHD (8.63%), and without either condition (43.13%) were evaluated. PTSD was assessed by the Clinician-Administered PTSD Scale (CAPS-IV). ADHD was assessed by the Wender Utah Rating Scale for ADHD (WURS ≥46)...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37694685/assistant-nurses-experiences-of-thirst-and-ethical-dilemmas-in-dying-patients-in-specialized-palliative-care-a-qualitative-study
#6
JOURNAL ARTICLE
Maria Friedrichsen, Tiny Jaarsma, Hans Thulesius, Nana Waldreus, Christel Hedman, Pier Jaarsma, Caroline Lythell, Micha Milovanovic, Marit Karlsson, Anna Milberg, Anne Söderlund Schaller
AIMS: To describe assistant nurses' experiences of thirst and ethical challenges in relation to thirst in terminally ill patients in specialized palliative care (PC) units. DESIGN: A qualitative, reflexive thematic design with an inductive analysis was used. METHODS: Data were collected during November 2021-January 2023. Twelve qualitative interviews with assistant nurses working in five different specialized PC units in different hospitals in Sweden were conducted...
September 11, 2023: Journal of Advanced Nursing
https://read.qxmd.com/read/37693460/discovery-of-95-ptsd-loci-provides-insight-into-genetic-architecture-and-neurobiology-of-trauma-and-stress-related-disorders
#7
Caroline M Nievergelt, Adam X Maihofer, Elizabeth G Atkinson, Chia-Yen Chen, Karmel W Choi, Jonathan Ri Coleman, Nikolaos P Daskalakis, Laramie E Duncan, Renato Polimanti, Cindy Aaronson, Ananda B Amstadter, Soren B Andersen, Ole A Andreassen, Paul A Arbisi, Allison E Ashley-Koch, S Bryn Austin, Esmina Avdibegoviç, Dragan Babic, Silviu-Alin Bacanu, Dewleen G Baker, Anthony Batzler, Jean C Beckham, Sintia Belangero, Corina Benjet, Carisa Bergner, Linda M Bierer, Joanna M Biernacka, Laura J Bierut, Jonathan I Bisson, Marco P Boks, Elizabeth A Bolger, Amber Brandolino, Gerome Breen, Rodrigo Affonseca Bressan, Richard A Bryant, Angela C Bustamante, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Anders D Børglum, Sigrid Børte, Leah Cahn, Joseph R Calabrese, Jose Miguel Caldas-de-Almeida, Chris Chatzinakos, Sheraz Cheema, Sean A P Clouston, LucÍa Colodro-Conde, Brandon J Coombes, Carlos S Cruz-Fuentes, Anders M Dale, Shareefa Dalvie, Lea K Davis, Jürgen Deckert, Douglas L Delahanty, Michelle F Dennis, Terri deRoon-Cassini, Frank Desarnaud, Christopher P DiPietro, Seth G Disner, Anna R Docherty, Katharina Domschke, Grete Dyb, Alma Dzubur Kulenovic, Howard J Edenberg, Alexandra Evans, Chiara Fabbri, Negar Fani, Lindsay A Farrer, Adriana Feder, Norah C Feeny, Janine D Flory, David Forbes, Carol E Franz, Sandro Galea, Melanie E Garrett, Bizu Gelaye, Joel Gelernter, Elbert Geuze, Charles F Gillespie, Aferdita Goci, Slavina B Goleva, Scott D Gordon, Lana Ruvolo Grasser, Camila Guindalini, Magali Haas, Saskia Hagenaars, Michael A Hauser, Andrew C Heath, Sian Mj Hemmings, Victor Hesselbrock, Ian B Hickie, Kelleigh Hogan, David Michael Hougaard, Hailiang Huang, Laura M Huckins, Kristian Hveem, Miro Jakovljevic, Arash Javanbakht, Gregory D Jenkins, Jessica Johnson, Ian Jones, Tanja Jovanovic, Karen-Inge Karstoft, Milissa L Kaufman, James L Kennedy, Ronald C Kessler, Alaptagin Khan, Nathan A Kimbrel, Anthony P King, Nastassja Koen, Roman Kotov, Henry R Kranzler, Kristi Krebs, William S Kremen, Pei-Fen Kuan, Bruce R Lawford, Lauren A M Lebois, Kelli Lehto, Daniel F Levey, Catrin Lewis, Israel Liberzon, Sarah D Linnstaedt, Mark W Logue, Adriana Lori, Yi Lu, Benjamin J Luft, Michelle K Lupton, Jurjen J Luykx, Iouri Makotkine, Jessica L Maples-Keller, Shelby Marchese, Charles Marmar, Nicholas G Martin, Gabriela A MartÍnez-Levy, Kerrie McAloney, Alexander McFarlane, Katie A McLaughlin, Samuel A McLean, Sarah E Medland, Divya Mehta, Jacquelyn Meyers, Vasiliki Michopoulos, Elizabeth A Mikita, Lili Milani, William Milberg, Mark W Miller, Rajendra A Morey, Charles Phillip Morris, Ole Mors, Preben Bo Mortensen, Mary S Mufford, Elliot C Nelson, Merete Nordentoft, Sonya B Norman, Nicole R Nugent, Meaghan O'Donnell, Holly K Orcutt, Pedro M Pan, Matthew S Panizzon, Gita A Pathak, Edward S Peters, Alan L Peterson, Matthew Peverill, Robert H Pietrzak, Melissa A Polusny, Bernice Porjesz, Abigail Powers, Xue-Jun Qin, Andrew Ratanatharathorn, Victoria B Risbrough, Andrea L Roberts, Barbara O Rothbaum, Alex O Rothbaum, Peter Roy-Byrne, Kenneth J Ruggiero, Ariane Rung, Heiko Runz, Bart P F Rutten, Stacey Saenz de Viteri, Giovanni Abrahão Salum, Laura Sampson, Sixto E Sanchez, Marcos Santoro, Carina Seah, Soraya Seedat, Julia S Seng, Andrey Shabalin, Christina M Sheerin, Derrick Silove, Alicia K Smith, Jordan W Smoller, Scott R Sponheim, Dan J Stein, Synne Stensland, Jennifer S Stevens, Jennifer A Sumner, Martin H Teicher, Wesley K Thompson, Arun K Tiwari, Edward Trapido, Monica Uddin, Robert J Ursano, Unnur Valdimarsdóttir, Leigh Luella van den Heuvel, Miranda Van Hooff, Sanne Jh van Rooij, Eric Vermetten, Christiaan H Vinkers, Joanne Voisey, Zhewu Wang, Yunpeng Wang, Monika Waszczuk, Heike Weber, Frank R Wendt, Thomas Werge, Michelle A Williams, Douglas E Williamson, Bendik S Winsvold, Sherry Winternitz, Erika J Wolf, Christiane Wolf, Yan Xia, Ying Xiong, Rachel Yehuda, Ross McD Young, Keith A Young, Clement C Zai, Gwyneth C Zai, Mark Zervas, Hongyu Zhao, Lori A Zoellner, John-Anker Zwart, Murray B Stein, Kerry J Ressler, Karestan C Koenen
Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 novel)...
September 2, 2023: medRxiv
https://read.qxmd.com/read/37585424/thirst-or-dry-mouth-in-dying-patients-a-qualitative-study-of-palliative-care-physicians-experiences
#8
JOURNAL ARTICLE
Maria Friedrichsen, Caroline Lythell, Tiny Jaarsma, Pier Jaarsma, Helene Ångström, Micha Milovanovic, Marit Karlsson, Anna Milberg, Hans Thulesius, Christel Hedman, Nana Waldréus, Anne Söderlund Schaller
INTRODUCTION: Thirst and dry mouth are common symptoms among patients at the end of life. In palliative care today, there is a focus on mouth care to alleviate thirst. There are no qualitative studies on thirst from a physician's experience, which is why this study is needed. PURPOSE: This study aimed to explore palliative care physicians' experiences and views of thirst in patients at the end of life. METHODS: A qualitative interview study with an inductive approach was carried out...
2023: PloS One
https://read.qxmd.com/read/37559116/ethical-challenges-around-thirst-in-end-of-life-care-experiences-of-palliative-care-physicians
#9
JOURNAL ARTICLE
Maria Friedrichsen, Caroline Lythell, Nana Waldréus, Tiny Jaarsma, Helene Ångström, Micha Milovanovic, Marit Karlsson, Anna Milberg, Hans Thulesius, Christel Hedman, Anne Söderlund Schaller, Pier Jaarsma
BACKGROUND: Thirst and dry mouth are common symptoms in terminally ill patients. In their day-to-day practice, palliative care physicians regularly encounter ethical dilemmas, especially regarding artificial hydration. Few studies have focused on thirst and the ethical dilemmas palliative care physicians encounter in relation to this, leading to a knowledge gap in this area. AIM: The aim of this study was to explore palliative care physicians' experiences of ethical challenges in relation to thirst in terminally ill patients...
August 9, 2023: BMC Medical Ethics
https://read.qxmd.com/read/37326535/inhibitory-control-and-alcohol-use-history-predict-changes-in-posttraumatic-stress-disorder-symptoms
#10
JOURNAL ARTICLE
Joseph DeGutis, Sam Agnoli, Charles E Gaudet, Anna Stumps, Sahra Kim, Travis C Evans, Audreyana Jagger-Rickels, William Milberg, Regina McGlinchey, Catherine B Fortier, Michael Esterman
OBJECTIVE: Posttraumatic stress disorder (PTSD) is associated with significant disability and can become chronic. Predictors of PTSD symptom changes over time, especially in those with a PTSD diagnosis, remain incompletely characterized. METHOD: In the present study, we examined 187 post-9/11 veterans ( M age = 32.8 years, 87% male) diagnosed with PTSD who performed two extensive clinical and cognitive evaluations approximately 2 years apart. RESULTS: We found that greater PTSD symptom reductions over time were related to lower lifetime drinking history and better baseline inhibitory control ability (Color-Word Inhibition and Inhibition/Switching), though not performance on other executive function tasks...
June 15, 2023: Neuropsychology
https://read.qxmd.com/read/37279923/generation-of-lexa-enhancer-trap-lines-in-drosophila-by-an-international-scholastic-network
#11
JOURNAL ARTICLE
Ella S Kim, Arjun Rajan, Kathleen Chang, Sanath Govindarajan, Clara Gulick, Eva English, Bianca Rodriguez, Orion Bloomfield, Stella Nakada, Charlotte Beard, Sarah O'Connor, Sophia Mastroianni, Emma Downey, Matthew Feigenbaum, Caitlin Tolentino, Abigail Pace, Marina Khan, Soyoun Moon, Jordan DiPrima, Amber Syed, Flora Lin, Yasmina Abukhadra, Isabella Bacon, John Beckerle, Sophia Cho, Nana Esi Donkor, Lucy Garberg, Ava Harrington, Mai Hoang, Nosa Lawani, Ayush Noori, Euwie Park, Ella Parsons, Philip Oravitan, Matthew Chen, Cristian Molina, Caleb Richmond, Adith Reddi, Jason Huang, Cooper Shugrue, Rose Coviello, Selma Unver, Matthew Indelicarto, Emir Islamovic, Rosemary McIlroy, Alana Yang, Mahdi Hamad, Elizabeth Griffin, Zara Ahmed, Asha Alla, Patricia Fitzgerald, Audrey Choi, Tanya Das, Yuchen Cheng, Joshua Yu, Tabor Roderiques, Ethan Lee, Longchao Liu, Jaekeb Harper, Jason Wang, Chris Suhr, Max Tan, Jacqueline Luque, A Russell Tam, Emma Chen, Max Triff, Lyric Zimmermann, Eric Zhang, Jackie Wood, Kaitlin Clark, Nat Kpodonu, Antar Dey, Alexander Ecker, Maximilian Chuang, Ramón Kodi Suzuki López, Harry Sun, Zijing Wei, Henry Stone, Chia Yu Joy Chi, Aiden Silvestri, Petra Orloff, Neha Nedumaran, Aletheia Zou, Leyla Ünver, Oscair Page, Minseo Kim, Terence Yan Tao Chan, Akili Tulloch, Andrea Hernandez, Aruli Pillai, Caitlyn Chen, Neil Chowdhury, Lina Huang, Anish Mudide, Garrett Paik, Alexandra Wingate, Lily Quinn, Chris Conybere, Luca Laiza Baumgardt, Rollo Buckley, Zara Kolberg, Ruth Pattison, Ashlyn Ahmad Shazli, Pia Ganske, Luca Sfragara, Annina Strub, Barney Collier, Hari Tamana, Dylan Ravindran, James Howden, Madeleine Stewart, Sakura Shimizu, Julia Braniff, Melanie Fong, Lucy Gutman, Danny Irvine, Sahil Malholtra, Jillian Medina, John Park, Alicia Yin, Harrison Abromavage, Breanna Barrett, Jacqueline Chen, Rachelle Cho, Mac Dilatush, Gabriel Gaw, Caitlin Gu, Jupiter Huang, Houston Kilby, Ethan Markel, Katie McClure, William Phillips, Benjamin Polaski, Amelia Roselli, Soleil Saint-Cyr, Ellie Shin, Kylan Tatum, Tai Tumpunyawat, Lucia Wetherill, Sara Ptaszynska, Maddie Zeleznik, Alexander Pesendorfer, Anna Nolan, Jeffrey Tao, Divya Sammeta, Laney Nicholson, Giao Vu Dinh, Merrin Foltz, An Vo, Maggie Ross, Andrew Tokarski, Samika Hariharan, Elaine Wang, Martha Baziuk, Ashley Tay, Yuk Hung Maximus Wong, Jax Floyd, Aileen Cui, Kieran Pierre, Nikita Coppisetti, Matthew Kutam, Dhruv Khurjekar, Anthony Gadzi, Ben Gubbay, Sophia Pedretti, Sofiya Belovich, Tiffany Yeung, Mercy Fey, Layla Shaffer, Arthur Li, Giancarlo Beritela, Kyle Huyghue, Greg Foster, Garrett Durso-Finley, Quinn Thierfelder, Holly Kiernan, Andrew Lenkowsky, Tesia Thomas, Nicole Cheng, Olivia Chao, Pia L'Etoile-Goga, Alexa King, Paris McKinley, Nicole Read, David Milberg, Leila Lin, Melinda Wong, Io Gilman, Samantha Brown, Lila Chen, Jordyn Kosai, Mark Verbinsky, Alice Belshaw-Hood, Honon Lee, Cathy Zhou, Maya Lobo, Asia Tse, Kyle Tran, Kira Lewis, Pratmesh Sonawane, Jonathan Ngo, Sophia Zuzga, Lillian Chow, Vianne Huynh, Wenyi Yang, Samantha Lim, Brandon Stites, Shannon Chang, Raenalyn Cruz-Balleza, Michaela Pelta, Stella Kujawski, Christopher Yuan, Elio Standen-Bloom, Oliver Witt, Karina Anders, Audrey Duane, Nancy Huynh, Benjamin Lester, Samantha Fung-Lee, Melanie Fung, Mandy Situ, Paolo Canigiula, Matijs Dijkgraaf, Wilbert Romero, Samantha Karmela Baula, Kimberly Wong, Ivana Xu, Benjamin Martinez, Reena Nuygen, Lucy Norris, Noah Nijensohn, Naomi Altman, Elise Maajid, Olivia Burkhardt, Jullian Chanda, Catherine Doscher, Alex Gopal, Aaron Good, Jonah Good, Nate Herrera, Lucas Lanting, Sophia Liem, Anila Marks, Emma McLaughlin, Audrey Lee, Collin Mohr, Emma Patton, Naima Pyarali, Claire Oczon, Daniel Richards, Nathan Good, Spencer Goss, Adeeb Khan, Reagan Madonia, Vivian Mitchell, Natasha Sun, Tarik Vranka, Diogo Garcia, Frida Arroyo, Eric Morales, Steven Camey, Giovanni Cano, Angelica Bernabe, Jennifer Arroyo, Yadira Lopez, Emily Gonzalez, Bryan Zumba, Josue Garcia, Esmeralda Vargas, Allen Trinidad, Noel Candelaria, Vanessa Valdez, Faith Campuzano, Emily Pereznegron, Jenifer Medrano, Jonathan Gutierrez, Evelyn Gutierrez, Ericka Taboada Abrego, Dayanara Gutierrez, Cristian Ortiz, Angelica Barnes, Eleanor Arms, Leo Mitchell, Ciara Balanzá, Jake Bradford, Harrison Detroy, Devin Ferguson, Ethel Guillermo, Anusha Manapragada, Daniella Nanula, Brigitte Serna, Khushi Singh, Emily Sramaty, Brian Wells, Matthew Wiggins, Melissa Dowling, Geraldine Schmadeke, Samantha Cafferky, Stephanie Good, Margaret Reese, Miranda Fleig, Alex Gannett, Cory Cain, Melody Lee, Paul Oberto, Jennifer Rinehart, Elaine Pan, Sallie Anne Mathis, Jessica Joiner, Leslie Barr, Cory J Evans, Alberto Baena-Lopez, Andrea Beatty, Jeanette Collette, Robert Smullen, Jeanne Suttie, Townley Chisholm, Cheryl Rotondo, Gareth Lewis, Victoria Turner, Lloyd Stark, Elizabeth Fox, Anjana Amirapu, Sangbin Park, Nicole Lantz, Anne E Rankin, Seung K Kim, Lutz Kockel
Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertions, we present molecular, genetic and tissue expression studies of 301 novel Stan-X LexA enhancer traps derived from mobilization of the index SX4 line. This includes insertions into distinct loci on the X, II and III chromosomes that were not previously associated with enhancer traps or targeted LexA constructs, an insertion into ptc, and seventeen insertions into natural transposons...
June 6, 2023: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/37272019/symptom-clusters-in-palliative-stage-cancer-correlate-with-proinflammatory-cytokine-cluster
#12
JOURNAL ARTICLE
Camilla Nilsberth, Valerie Sackmann, Karin Fransson, Maria Jakobsson, Marit Karlsson, Anna Milberg
BACKGROUND: Patients with palliative-stage cancer often suffer from a variety of debilitating symptoms which have been shown to appear in clusters. It is suggested that cytokines cause many such symptoms, and elevated cytokine production has been shown to correlate with symptoms. However, symptom clusters have not been thoroughly analyzed in relation to cytokine clusters. The aim of the present study was to identify symptom clusters and cytokine clusters in Swedish cancer patients, and to investigate correlations between the identified symptom clusters and cytokine clusters...
May 2023: Annals of Palliative Medicine
https://read.qxmd.com/read/37215712/associations-between-gait-performance-and-pain-intensity-psychosocial-factors-executive-functions-as-well-as-prefrontal-cortex-activity-in-chronic-low-back-pain-patients-a-cross-sectional-fnirs-study
#13
JOURNAL ARTICLE
Toan Nguyen, Martin Behrens, Kim-Charline Broscheid, Robert Bielitzki, Saskia Weber, Saskia Libnow, Victoria Malczewski, Lukas Baldauf, Xenia Milberger, Lena Jassmann, Anne Wustmann, Katharina Meiler, Steffen Drange, Jörg Franke, Lutz Schega
INTRODUCTION: Activities of daily living, such as walking, are impaired in chronic low back pain (CLBP) patients compared to healthy individuals. Thereby, pain intensity, psychosocial factors, cognitive functioning and prefrontal cortex (PFC) activity during walking might be related to gait performance during single and dual task walking (STW, DTW). However, to the best of our knowledge, these associations have not yet been explored in a large sample of CLBP patients. METHOD: Gait kinematics (inertial measurement units) and PFC activity (functional near-infrared spectroscopy) during STW and DTW were measured in 108 CLBP patients (79 females, 29 males)...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37087755/semantic-priming-from-uncued-distractors-in-alzheimer-s-disease
#14
JOURNAL ARTICLE
Julie A Higgins, William Milberg, Regina McGlinchey
RESEARCH QUESTION: Are semantic impairments in Alzheimer's disease (AD) partially due to deficits in spatial attention? METHODS AND RESULTS: In a target detection task, both older adults (OAs) and AD individuals were facilitated by valid spatial cues, but only OAs were impaired by invalid cues compared to neutral. In a reading task, spatial cues validly or invalidly cued the location of pictures, which were related or unrelated to subsequent, centrally presented, words...
April 23, 2023: Experimental Aging Research
https://read.qxmd.com/read/37023279/neurobiological-and-genetic-correlates-of-the-dissociative-subtype-of-posttraumatic-stress-disorder
#15
JOURNAL ARTICLE
Erika J Wolf, Sage E Hawn, Danielle R Sullivan, Mark W Miller, Victoria Sanborn, Emma Brown, Zoe Neale, Dana Fein-Schaffer, Xiang Zhao, Mark W Logue, Catherine B Fortier, Regina E McGlinchey, William P Milberg
Approximately 10%-30% of individuals with posttraumatic stress disorder (PTSD) exhibit a dissociative subtype of the condition defined by symptoms of depersonalization and derealization. This study examined the psychometric evidence for the dissociative subtype of PTSD in a sample of young, primarily male post-9/11-era Veterans ( n = 374 at baseline and n = 163 at follow-up) and evaluated its biological correlates with respect to resting state functional connectivity (default mode network [DMN]; n = 275), brain morphology (hippocampal subfield volume and cortical thickness; n = 280), neurocognitive functioning ( n = 337), and genetic variation ( n = 193)...
April 6, 2023: J Psychopathol Clin Sci
https://read.qxmd.com/read/36951458/the-impact-of-blast-exposure-with-or-without-traumatic-brain-injury-on-metabolic-abnormalities-in-post-9-11-veterans
#16
JOURNAL ARTICLE
Dora Lendvai, Robin Whittemore, Julie A Womack, Catherine B Fortier, William P Milberg, Jennifer R Fonda
OBJECTIVE: The primary aim included explorations of: (1) the associations between the history of blast exposure (BE), close blast exposure (CBE), and blast-related traumatic brain injury (bTBI) and metabolic abnormality; and (2) the potential mediating effect of comorbid psychological and somatic conditions on these associations. The secondary aim explored the association of dose-response impact of BE, CBE, and bTBI and metabolic abnormality. SETTING: Data were collected by the Translational Research Center for TBI and Stress Disorders (TRACTS)...
March 23, 2023: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/36902865/sleep-quality-disturbances-are-associated-with-white-matter-alterations-in-veterans-with-post-traumatic-stress-disorder-and-mild-traumatic-brain-injury
#17
JOURNAL ARTICLE
Philine Rojczyk, Johanna Seitz-Holland, Elisabeth Kaufmann, Valerie J Sydnor, Cara L Kim, Lisa F Umminger, Tim L T Wiegand, Jeffrey P Guenette, Fan Zhang, Yogesh Rathi, Sylvain Bouix, Ofer Pasternak, Catherine B Fortier, David Salat, Sidney R Hinds, Florian Heinen, Lauren J O'Donnell, William P Milberg, Regina E McGlinchey, Martha E Shenton, Inga K Koerte
Sleep disturbances are strongly associated with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD and mTBI have been linked to alterations in white matter (WM) microstructure, but whether poor sleep quality has a compounding effect on WM remains largely unknown. We evaluated sleep and diffusion magnetic resonance imaging (dMRI) data from 180 male post-9/11 veterans diagnosed with (1) PTSD ( n = 38), (2) mTBI ( n = 25), (3) comorbid PTSD+mTBI ( n = 94), and (4) a control group with neither PTSD nor mTBI ( n = 23)...
March 6, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36866717/evaluation-of-peer-mediated-systems-navigation-for-ageing-families-of-individuals-with-developmental-disabilities
#18
JOURNAL ARTICLE
C Marsack-Topolewski, S Milberger, E Janks, N Anderson, M Bray, P S Samuel
BACKGROUND: As individuals with intellectual and developmental disabilities (I/DD) age, services often diminish, with many family caregivers experiencing challenges finding and navigating services. The purpose of this study was to examine the benefits of a state-wide family support project for ageing caregivers (50+) of adults with I/DD in accessing and using services. METHOD: A one-group pre-test-post-test design was used to determine if participation in the MI-OCEAN intervention grounded in the Family Quality of Life (FQOL) theory reduced ageing caregivers' (n = 82) perceptions of barriers to accessing, using and needing formal services...
March 3, 2023: Journal of Intellectual Disability Research: JIDR
https://read.qxmd.com/read/36792580/correction-to-for-whom-the-bell-tolls-psychopathological-and-neurobiological-correlates-of-a-dna-methylation-index-of-time-to-death
#19
Sage E Hawn, Xiang Zhao, Danielle R Sullivan, Mark Logue, Dana Fein-Schaffer, William Milberg, Regina McGlinchey, Mark W Miller, Erika J Wolf
No abstract text is available yet for this article.
February 15, 2023: Translational Psychiatry
https://read.qxmd.com/read/36781401/poorer-inhibitory-control-uniquely-contributes-to-greater-functional-disability-in-post-9-11-veterans
#20
JOURNAL ARTICLE
Joseph DeGutis, Sam Agnoli, John P K Bernstein, Audreyana Jagger-Rickels, Travis C Evans, Catherine B Fortier, Regina E McGlinchey, William P Milberg, Michael Esterman
OBJECTIVE: Post-9/11 Veterans endorse greater self-reported functional disability than 80% of the adult population. Previous studies of trauma-exposed populations have shown that increased post-traumatic stress disorder (PTSD) and depressive symptoms are consistently associated with greater disability. Additionally, poorer cognitive performance in the domain of executive functions, particularly inhibitory control, has been associated with disability, though it is unclear if this effect is independent of and/or interacts with PTSD and depression...
February 13, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
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