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Adam D LaMotte, Casey T Taft, Robin P Weatherill, Melynda D Casement, Suzannah K Creech, William P Milberg, Catherine B Fortier, Regina E McGlinchey
Objective: This study investigated sleep problems and physical pain as moderators of the relationship between PTSD symptoms and aggression among returning veterans. Prior research has demonstrated associations between PTSD symptoms and aggression, but little work has sought to identify moderators of this relationship. Sleep problems and physical pain are both common clinical problems among veterans and have theoretical links to aggression. Method: Participants were 103 returning service members and veterans recruited from the greater Boston area and enrolled in the VA Translational Research Center for Traumatic Brain Injury (TBI) and Stress Disorders (TRACTS)...
August 15, 2016: Psychological Trauma: Theory, Research, Practice and Policy
Maria Friedrichsen, Yvonne Hajradinovic, Maria Jakobsson, Per Milberg, Anna Milberg
: ᅟ: There is little evidence regarding primary healthcare team members' perceptions concerning palliative care consultation team (PCCT) and palliative care (PC) issues on their own wards. PURPOSE: This study aimed to study whether a PCCT can influence and change primary healthcare team members' perceptions regarding the palliative care at the end of life they are providing to patients in their own acute wards. METHODS: The intervention was a PCCT visiting surgical and internal medicine wards in 1 year...
September 16, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Guusje van der Leeuw, Suzanne G Leveille, Richard N Jones, Jeffrey M Hausdorff, Robert McLean, Dan K Kiely, Margaret Gagnon, William P Milberg
There is a need for validated measures of attention for use in longitudinal studies of older populations. We studied 249 participants aged 80 to 101 years using the population-based MOBILIZE Boston Study. Four subscales of the Test of Everyday Attention (TEA) were included, measuring attention switching, selective, sustained and divided attention and a neuropsychological battery including validated measures of multiple cognitive domains measuring attention, executive function and memory. The TEA previously has not been validated in persons aged 80 and older...
September 2, 2016: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Blanca Torres-Manrique, Andreu Nolasco-Bonmati, Loreto Maciá-Soler, Matías Milberg, Alba Noemi Vilca, María José López-Montesinos, Víctor Manuel González-Chordá
OBJECTIVE: To compare the agreement between two surgical checklists implanted in two hospitals in Spain and Argentina, using the international classification for patient safety as a framework. METHOD: This was an expert opinion study carried out using an ad hoc questionnaire in electronic format, which included 7 of the 13 categories of the international classification for patient safety. Fifteen surgical security experts from each country participated in this study by classifying the items on the checklists into the selected ICPS categories...
September 2016: Revista Gaúcha de Enfermagem
Naomi Sadeh, Erika J Wolf, Mark W Logue, Joanna Lusk, Jasmeet P Hayes, Regina E McGlinchey, William P Milberg, Annjanette Stone, Steven A Schichman, Mark W Miller
The frequent co-occurrence of antisocial behavior and other disinhibited phenotypes reflects a highly heritable externalizing spectrum. We examined the molecular genetic basis of this spectrum by testing polygenic associations with psychopathology symptoms, impulsive traits, and cognitive functions in two samples of primarily military veterans (n =537, n =194). We also investigated whether polygenic risk for externalizing moderated the effects of trauma on these phenotypes. As hypothesized, polygenic risk positively predicted externalizing psychopathology and negatively predicted performance on inhibitory control tasks...
May 2016: Clinical Psychological Science
Mark W Miller, Emily Sperbeck, Meghan E Robinson, Naomi Sadeh, Erika J Wolf, Jasmeet P Hayes, Mark Logue, Steven A Schichman, Angie Stone, William Milberg, Regina McGlinchey
The default mode network (DMN) has been used to study disruptions of functional connectivity in a wide variety of psychiatric and neurological conditions, including posttraumatic stress disorder (PTSD). Studies indicate that the serotonin system exerts a modulatory influence on DMN connectivity; however, no prior study has examined associations between serotonin receptor gene variants and DMN connectivity in either clinical or healthy samples. We examined serotonin receptor single nucleotide polymorphisms (SNPs), PTSD, and their interactions for association with DMN connectivity in 134 White non-Hispanic veterans...
2016: Frontiers in Neuroscience
Gerrit Frommeyer, Benedict Brücher, Henning von der Ahe, Sven Kaese, Dirk G Dechering, Simon Kochhäuser, Harilaos Bogossian, Peter Milberg, Lars Eckardt
In several case reports proarrhythmic effects of citalopram and escitalopram have been reported. Systematic analyses on prorarrhythmic effects of these drugs are not yet available. The aim of the present study was to investigate if application of citalopram, escitalopram or haloperidol provokes polymorphic ventricular tachycardia in a sensitive model of proarrhythmia. In isolated rabbit hearts monophasic action potentials and ECG showed a significant QT-prolongation after application of citalopram (2µM: +47ms, 4µM: +56ms, P<0...
October 5, 2016: European Journal of Pharmacology
Vincent Corbo, Melissa A Amick, William P Milberg, Regina E McGlinchey, David H Salat
Early life trauma (ELT) has been shown to impair affective control and attention well into adulthood. Neuroimaging studies have further shown that ELT was associated with decreased white matter integrity in the prefrontal areas in children and adults. However, no study to date has looked at the relationship between white matter integrity and affective control in individuals with and without a history of ELT. To examine this, we tested 240 Veterans with (ELT N = 80) and without (NoELT N = 160) a history of childhood sexual abuse, physical abuse or family violence...
August 2016: Journal of Psychiatric Research
Joseph DeGutis, Christopher Chiu, Michelle Thai, Michael Esterman, William Milberg, Regina McGlinchey
While the associations between psychological distress (e.g., posttraumatic stress disorder [PTSD], depression) and sleep dysfunction have been demonstrated in trauma-exposed populations, studies have not fully explored the associations between sleep dysfunction and the wide range of common physical and physiological changes that can occur after trauma exposure (e.g., pain, cardiometabolic risk factors). We aimed to clarify the unique associations of psychological and physical trauma sequelae with different aspects of self-reported sleep dysfunction...
May 16, 2016: Behavioral Sleep Medicine
Victoria N Poole, Meghan E Robinson, Omar Singleton, Joseph DeGutis, William P Milberg, Regina E McGlinchey, David H Salat, Michael Esterman
Distractor suppression, the ability to filter and ignore task-irrelevant information, is critical for efficient task performance. While successful distractor suppression relies on a balance of activity in neural networks responsible for attention maintenance (dorsal attention network; DAN), reorientation (ventral attention network; VAN), and internal thought (default mode network, DMN), the degree to which intrinsic connectivity within and between these networks contributes to individual differences in distractor suppression ability is not well-characterized...
June 2016: Neuropsychologia
John A Milberg
BACKGROUND: The management of HIV infection requires extensive, longitudinal information record-keeping and coordination to ensure optimal monitoring and outcomes of care and treatment. OBJECTIVE: Agencies funded by The Ryan White HIV/AIDS Treatment Modernization Act are increasingly required to monitor the quality of their HIV care and generate reports for funding agencies. To assist in their data collection and reporting capacity, the HIV/AIDS Bureau in the Health Resources and Services Administration released its first version of a software application called CAREWare in 2000...
April 23, 2016: Journal of the American Medical Informatics Association: JAMIA
Leonie A Gough, Anne Sverdrup-Thygeson, Per Milberg, Hanne E Pilskog, Nicklas Jansson, Mats Jonsell, Tone Birkemoe
Ancient trees are considered one of the most important habitats for biodiversity in Europe and North America. They support exceptional numbers of specialized species, including a range of rare and endangered wood-living insects. In this study, we use a dataset of 105 sites spanning a climatic gradient along the oak range of Norway and Sweden to investigate the importance of temperature and precipitation on beetle species richness in ancient, hollow oak trees. We expected that increased summer temperature would positively influence all wood-living beetle species whereas precipitation would be less important with a negligible or negative impact...
December 2015: Ecology and Evolution
Milan P Stojanovic, Jennifer Fonda, Catherine Brawn Fortier, Diana M Higgins, James L Rudolph, William P Milberg, Regina E McGlinchey
OBJECTIVE: Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) are common among US veterans of Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND). We postulated that these injuries may modulate pain processing in these individuals and affect their subjective pain levels. DESIGN: Cross-sectional. SUBJECTS: 310 deployed service members of OEF/OIF/OND without a lifetime history of moderate or severe TBI were included in this study...
April 3, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Vincent Corbo, David H Salat, Margaret A Powell, William P Milberg, Regina E McGlinchey
Chronic Pain (CP) has been associated with changes in gray matter integrity in the cingulate and insular cortex. However, these changes have not been studied in Veterans, despite high prevalence rates of CP and interactions with combat-derived disorders. In the current study, 54 Veterans with a history of CP and 103 Veterans without CP were recruited from the Translational Research Center for Traumatic Brain Injury and Stress Disorders (TRACTS). Cortical thickness from structural MRI scans was determined using the FreeSurfer software package...
March 30, 2016: Psychiatry Research
Gerrit Frommeyer, Christina Fischer, Philipp S Lange, Patrick Leitz, Michael Fehr, Harilaos Bogossian, Peter Milberg, Lars Eckardt
In several case reports a prolongation of the QT-interval and even proarrhythmic effects of fluconazole and voriconazole were reported. The aim of the present study was to investigate if application of fluconazole or voriconazole has the potential to provoke polymorphic ventricular tachycardia in a sensitive model of proarrhythmia. In female rabbits, fluconazole (10, 30 and 50 µM, n=6) and voriconazole (10, 30 and 50 µM, n=6) were infused after obtaining baseline data. Eight endocardial and epicardial monophasic action potentials and a simultaneously recorded 12-lead ECG showed a significant QT prolongation after application of fluconazole as compared with baseline (10 µM:+12 ms, 30 µM:+22 ms, 50 µM:+37 ms; P<0...
April 5, 2016: European Journal of Pharmacology
Per Milberg, Karl-Olof Bergman, Kerem Sancak, Nicklas Jansson
Old living oaks (Quercus robur) are known as a very species-rich habitat for saproxylic beetles, but it is less clear to what extent such veteran trees differ from an even rarer feature: downed trunks of large oaks. In this study, we set out to sample this habitat, using window traps, with two aims: (1) to describe the variation of assemblages among downed trunks of different type and (2) to compare beetles on downed oaks with data from veteran standing trees. The results showed that trunk volume and sun exposure better explained assemblages as well as species numbers on downed trunks than did decay stage...
March 2016: Ecology and Evolution
N Sadeh, J M Spielberg, M W Logue, E J Wolf, A K Smith, J Lusk, J P Hayes, E Sperbeck, W P Milberg, R E McGlinchey, D H Salat, W C Carter, A Stone, S A Schichman, D E Humphries, M W Miller
No abstract text is available yet for this article.
March 2016: Molecular Psychiatry
Elizabeth C Leritz, Regina E McGlinchey, David H Salat, William P Milberg
We examined how serum cholesterol, an established risk factor for cerebrovascular disease (CVD), relates to cognitive function in healthy middle-older aged individuals with no neurologic or CVD history. A complete lipid panel was obtained from a cohort of one hundred twenty individuals, ages 43-85, who also underwent a comprehensive neuropsychological examination. In order to reduce the number of variables and empirically identify broad cognitive domains, scores from neuropsychological tests were submitted into a factor analysis...
April 2016: Metabolic Brain Disease
Heléne Eriksson, Anna Milberg, Katarina Hjelm, Maria Friedrichsen
BACKGROUND: Although stroke is a significant public health challenge and the need for palliative care has been emphasized for these patients, there is limited data on end-of-life care for patients dying from stroke. OBJECTIVE: To study the end-of-life care during the last week of life for patients who had died of stroke in terms of registered symptom, symptom management, and communication, in comparison with patients who had died of cancer. DESIGN: This study is a retrospective, comparative registry study...
2016: PloS One
Märta Sund Levander, Anna Milberg, Nils Rodhe, Pia Tingström, Ewa Grodzinsky
AIM: The aim was to compare 5-year survival in two included cohorts (from year 2000 and year 2007) of 249 nursing home residents (NHR) in this retrospective, comparative study. METHODS: The cohorts were compared regarding chronic diseases, medication, physical/cognitive/nutritional status, body mass index, body temperature and 5-year mortality. Factors correlated with 5-year survival were determined using Cox regression analysis. RESULTS: In average, cohort 2007 survived 31 ± 16 months and cohort 2000, 38 ± 13 months, p < 0...
February 4, 2016: Scandinavian Journal of Caring Sciences
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