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https://www.readbyqxmd.com/read/28523226/interpersonal-early-life-trauma-alters-amygdala-connectivity-and-sustained-attention-performance
#1
Francesca C Fortenbaugh, Vincent Corbo, Victoria Poole, Regina McGlinchey, William Milberg, David Salat, Joseph DeGutis, Michael Esterman
INTRODUCTION: Interpersonal early life trauma (I-ELT) is associated with a myriad of functional impairments in adulthood, increased risk of drug addiction, and neuropsychiatric disorders. While deficits in emotional regulation and amygdala functioning are well characterized, deficits in general cognitive functioning have also been documented. However, the neural underpinnings of cognitive dysfunction in adults with a history of I-ELT and the potential relationship between amygdala-based functional connectivity and behavioral performance are currently poorly understood...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28494120/posttraumatic-stress-disorder-symptom-severity-is-associated-with-reduced-default-mode-network-connectivity-in-individuals-with-elevated-genetic-risk-for-psychopathology
#2
Danielle R Miller, Mark W Logue, Erika J Wolf, Hannah Maniates, Meghan E Robinson, Jasmeet P Hayes, Annjanette Stone, Steven Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
BACKGROUND: Accumulating evidence suggests that posttraumatic stress disorder (PTSD) is associated with disrupted default mode network (DMN) connectivity, but findings across studies have not been uniform. Individual differences in relevant genes may account for some of the reported variability in the relationship between DMN connectivity and PTSD. In this study, we investigated this possibility using genome-wide association study (GWAS) derived polygenic risk scores (PRSs) for relevant psychiatric traits...
May 11, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28486051/characterization-of-differences-in-functional-connectivity-associated-with-close-range-blast-exposure
#3
Meghan Robinson, Dustin Clark, William Milberg, Regina McGlinchey, David Salat
Despite the prevalence of blast injuries in recent overseas conflicts, our knowledge of their impact on neural health is lacking. We have recently published work demonstrating differences in functional magnetic resonance imaging (fMRI) connectivity that were specific to close-range blast exposure (CBE), as opposed to other prevalent military-related factors. Here, we replicate this finding in an independent sample of 135 Veterans, again finding that CBE, regardless of concussion, is predictive of persistent changes in brain physiology...
May 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28472407/traumatic-brain-injury-and-attempted-suicide-among-veterans-of-the-wars-in-iraq-and-afghanistan
#4
Jennifer R Fonda, Lisa Fredman, Susan B Brogly, Regina E McGlinchey, William P Milberg, Jaimie L Gradus
Studies of the association between traumatic brain injury (TBI) and suicide attempt have yielded conflicting results. Furthermore, no studies have examined the possible mediating role of common comorbid psychiatric conditions in this association. This study used Veterans Affairs registry data to evaluate the associations between deployment-related TBI, psychiatric diagnoses, and attempted suicide among 273,591 veterans deployed in support of Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn, and who received care from the Department of Veterans Affairs during 2007-2012...
May 3, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28449077/executive-network-activation-is-linked-to-walking-speed-in-older-adults-functional-mri-and-tcd-ultrasound-evidence-from-the-mobilize-boston-study
#5
Azizah J Jor'dan, Victoria N Poole, Ikechukwu Iloputaife, William Milberg, Brad Manor, Michael Esterman, Lewis A Lipsitz
Background: Changes in cerebral blood flow velocity (CBF) in response to a cognitive task (task-related ΔCBF) have been shown by Transcranial Doppler ultrasonography (TCD) to be reduced in slow walkers. However, it is unknown whether reduced task-related ΔCBF is associated with reduced neural activity in specific brain regions, as measured by blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI). Methods: We assessed the regional changes in neural activity associated with reduced middle cerebral artery (MCA) task-related ΔCBF to an executive task and slow walking speed in 67 community-dwelling older adults from the MOBILIZE Boston Study...
April 26, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28422901/the-deployment-trauma-phenotype-and-employment-status-in-veterans-of-the-wars-in-iraq-and-afghanistan
#6
Melissa M Amick, Mark Meterko, Catherine B Fortier, Jennifer R Fonda, William P Milberg, Regina E McGlinchey
OBJECTIVES: To determine the prevalence of comorbid mild traumatic brain injury (mTBI), posttraumatic stress disorder (PTSD), and depression, termed the deployment trauma phenotype (DTP), and its constituent diagnoses' impact on unemployment status in a national cohort of veterans. SETTING: Retrospective analysis of the comprehensive TBI evaluation, a Veterans Affairs-wide protocol for assessing TBI, employment status, and psychiatric impressions. PARTICIPANTS: The final data set consisted of 48 821 veterans...
April 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28370780/higher-serum-cholesterol-is-associated-with-intensified-age-related-neural-network-decoupling-and-cognitive-decline-in-early-to-mid-life
#7
Jeffrey M Spielberg, Naomi Sadeh, Elizabeth C Leritz, Regina E McGlinchey, William P Milberg, Jasmeet P Hayes, David H Salat
Mounting evidence indicates that serum cholesterol and other risk factors for cardiovascular disease intensify normative trajectories of age-related cognitive decline. However, the neural mechanisms by which this occurs remain largely unknown. To understand the impact of cholesterol on brain networks, we applied graph theory to resting-state fMRI in a large sample of early- to mid-life Veterans (N = 206, Meanage  = 32). A network emerged (centered on the banks of the superior temporal sulcus) that evidenced age-related decoupling (i...
June 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28287287/reporting-of-symptoms-associated-with-concussion-by-oef-oif-ond-veterans-comparison-between-research-and-clinical-contexts
#8
Colleen E Jackson, Leslie Nordstrom, Jennifer R Fonda, Catherine B Fortier, William P Milberg, Regina E McGlinchey
OBJECTIVE: Veterans from recent military conflicts frequently report persisting symptoms associated with concussion well beyond the expected period of recovery following mild traumatic brain injury. This study examined differences in the reporting of symptoms associated with concussion between clinical and research contexts. METHODS: This naturalistic comparison included 91 Veterans from Operations Enduring Freedom (OEF), Iraqi Freedom (OIF) and New Dawn (OND). All participants were enrolled in a longitudinal study focused on traumatic brain injury and stress-related disorders and had also completed a VHA Comprehensive TBI Evaluation...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28220315/attachment-figures-when-death-is-approaching-a-study-applying-attachment-theory-to-adult-patients-and-family-members-experiences-during-palliative-home-care
#9
Anna Milberg, Maria Friedrichsen
PURPOSE: Attachment theory is currently receiving much attention in relation to how adults cope with severe illness. The study aims were using the experiences of patients and family members to explore attachment figures (a central concept within the theory) during palliative home care. METHODS: Twelve patients and 14 family members were interviewed during ongoing palliative home care. The interviews were analysed using qualitative content analysis. RESULTS: Four types of attachment figures were identified: (i) family and friends, (ii) health care practitioners, (iii) pets and (iv) God...
February 20, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28211592/a-methodology-for-assessing-deployment-trauma-and-its-consequences-in-oef-oif-ond-veterans-the-tracts-longitudinal-prospective-cohort-study
#10
Regina E McGlinchey, William P Milberg, Jennifer R Fonda, Catherine Brawn Fortier
Many US veterans of Afghanistan and Iraq have multiple physical and psychiatric problems. A major focus of research has been on determining the effects of mild Traumatic Brain Injury (mTBI), but mTBI is rarely diagnosed in the absence of co-occurring conditions such as blast exposure, post-traumatic stress disorder (PTSD), depression, substance abuse, etc. These potentially interactive psychological and physical conditions produce complex patterns of cognitive, psychological, and physical symptoms that impede civilian reintegration and complicate efficient and effective treatment planning...
February 17, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28077398/mild-traumatic-brain-injury-is-associated-with-reduced-cortical-thickness-in-those-at-risk-for-alzheimer-s-disease
#11
Jasmeet P Hayes, Mark W Logue, Naomi Sadeh, Jeffrey M Spielberg, Mieke Verfaellie, Scott M Hayes, Andrew Reagan, David H Salat, Erika J Wolf, Regina E McGlinchey, William P Milberg, Annjanette Stone, Steven A Schichman, Mark W Miller
Moderate-to-severe traumatic brain injury is one of the strongest environmental risk factors for the development of neurodegenerative diseases such as late-onset Alzheimer's disease, although it is unclear whether mild traumatic brain injury, or concussion, also confers risk. This study examined mild traumatic brain injury and genetic risk as predictors of reduced cortical thickness in brain regions previously associated with early Alzheimer's disease, and their relationship with episodic memory. Participants were 160 Iraq and Afghanistan War veterans between the ages of 19 and 58, many of whom carried mild traumatic brain injury and post-traumatic stress disorder diagnoses...
March 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28069854/for-many-served-by-the-ryan-white-hiv-aids-program-disparities-in-viral-suppression-decreased-2010-14
#12
Rupali K Doshi, John Milberg, Theresa Jumento, Tracy Matthews, Antigone Dempsey, Laura W Cheever
For twenty-five years, the Ryan White HIV/AIDS Program has supported a comprehensive system of health services for vulnerable and under- or uninsured people living with HIV. Using data from the Health Resources and Services Administration about people living with HIV and served by the Ryan White HIV/AIDS Program, we found reductions in disparities in viral suppression rates between 2010 and 2014-with rates for Blacks/African Americans, adolescents and young adults, and people living in the South becoming more similar to rates for Whites, older adults, and people in other regions of the United States, respectively...
January 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28039911/effective-suppression-of-atrial-fibrillation-by-the-antihistaminic-agent-antazoline-first-experimental-insights-into-a-novel-antiarrhythmic-agent
#13
Gerrit Frommeyer, Magdalena Sterneberg, Dirk G Dechering, Sven Kaese, Nils Bögeholz, Christian Pott, Michael Fehr, Harilaos Bogossian, Peter Milberg, Lars Eckardt
INTRODUCTION: The antihistaminic antazoline (ANT) was reported to be highly effective and safe for rapid conversion of atrial fibrillation (AF). We therefore analyzed underlying mechanisms in an experimental whole-heart model. METHODS AND RESULTS: Isolated and retrogradely perfused rabbit hearts underwent a standardized protocol employing atrial burst pacing-induced AF in five of 20 hearts under baseline conditions (seven episodes). Thereafter, a combination of acetylcholine and isoproterenol was employed to enhance AF occurrence...
April 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27976973/elevated-rates-of-memory-impairment-in-military-service-members-and-veterans-with-posttraumatic-stress-disorder
#14
Nikki H Stricker, Sara M Lippa, Deborah L Green, Susan M McGlynn, Laura J Grande, William P Milberg, Regina E McGlinchey
INTRODUCTION: Studies investigating the neurocognitive effects of posttraumatic stress disorder (PTSD) routinely find "deficits" in various cognitive domains. However, the rate of cognitive impairment in individuals with PTSD remains unclear, as studies have focused on null hypothesis testing (NHT) and inferring patterns of impairment rather than empirically determining the rate of cognitive impairment in this sample. METHOD: This study examined rates of cognitive impairment using a domain-specific approach in non-treatment-seeking Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn service members and veterans with (n = 92) and without (n = 79) PTSD and without substance abuse/dependence who passed a performance validity measure and were matched on age, education, estimated IQ, and ethnicity...
December 15, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27920510/the-clock-in-the-box-a-brief-cognitive-screen-is-associated-with-failure-to-return-home-in-an-elderly-hospitalized-sample
#15
Colleen E Jackson, Laura J Grande, Kelly Doherty, Elizabeth Archambault, Brittany Kelly, Jane A Driver, William P Milberg, Regina McGlinchey, James L Rudolph
PURPOSE: Cognitive screening upon hospital admission can provide important information about the patient's ability to process information during the inpatient stay. The Clock-in-the-Box (CIB) is a rapidly administered cognitive screening measure which has been previously validated with cognitive screening and neuropsychological assessments. The purpose of this study is to demonstrate the predictive validity of the CIB for discharge location among a sample of older medical inpatients. PATIENTS AND METHODS: Hospitalized Veterans (N=218), aged 55 years and older, were recruited on the day after admission after they gave their consent...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27898145/%C3%A2-hoppas-p%C3%A3-det-b%C3%A3-sta-planera-f%C3%A3-r-det-s%C3%A3-msta%C3%A2-stort-v%C3%A3-rde-i-att-identifiera-och-kommunicera-med-d%C3%A3-ende-patienter
#16
Anna Milberg, Marit Karlsson
No abstract text is available yet for this article.
November 22, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27880814/health-care-professionals-understandings-of-cross-cultural-interaction-in-end-of-life-care-a-focus-group-study
#17
Anna Milberg, Sandra Torres, Pernilla Ågård
OBJECTIVE: The academic debate on cross-cultural interaction within the context of end-of-life care takes for granted that this interaction is challenging. However, few empirical studies have actually focused on what health care professionals think about this interaction. This study aimed to explore health care professionals' understandings of cross-cultural interaction during end-of-life care. METHODS: Sixty end-of-life care professionals were recruited from eleven care units in Sweden to take part in focus group interviews...
2016: PloS One
https://www.readbyqxmd.com/read/27837324/a-good-death-from-the-perspective-of-palliative-cancer-patients
#18
Lisa Kastbom, Anna Milberg, Marit Karlsson
PURPOSE: Although previous research has indicated some recurrent themes and similarities between what patients from different cultures regard as a good death, the concept is complex and there is lack of studies from the Nordic countries. The aim of this study was to explore the perception of a good death in dying cancer patients in Sweden. METHODS: Interviews were conducted with 66 adult patients with cancer in the palliative phase who were recruited from home care and hospital care...
March 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27767897/manfred-frank-greiffenstein-a-remembrance
#19
William Milberg
No abstract text is available yet for this article.
November 2016: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27732020/sleep-problems-and-physical-pain-as-moderators-of-the-relationship-between-ptsd-symptoms-and-aggression-in-returning-veterans
#20
Adam D LaMotte, Casey T Taft, Robin P Weatherill, Melynda D Casement, Suzannah K Creech, William P Milberg, Catherine B Fortier, Regina E McGlinchey
OBJECTIVE: This study investigated sleep problems and physical pain as moderators of the relationship between PTSD symptoms and aggression among returning veterans. Prior research has demonstrated associations between PTSD symptoms and aggression, but little work has sought to identify moderators of this relationship. Sleep problems and physical pain are both common clinical problems among veterans and have theoretical links to aggression. METHOD: Participants were 103 returning service members and veterans recruited from the greater Boston area and enrolled in the VA Translational Research Center for Traumatic Brain Injury (TBI) and Stress Disorders (TRACTS)...
January 2017: Psychological Trauma: Theory, Research, Practice and Policy
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