keyword
https://read.qxmd.com/read/38503850/metformin-and-progestins-in-women-with-atypical-hyperplasia-or-endometrial-cancer-systematic-review-and-meta-analysis
#21
REVIEW
Leila Adamyan, Laura Pivazyan, Sapiyat Isaeva, Roman Shapovalenko, Araksya Zakaryan
PURPOSE: To assess metformin's effectiveness in adding it to progestin-based hormone therapy for treating atypical endometrial hyperplasia (AEH) and early endometrial cancer (EEC). METHODS: We conducted a systematic review and meta-analysis following PRISMA guidelines (registration number CRD42023399094). We searched databases for studies up to March 2023, including randomized and non-randomized clinical trials in English. RESULTS: Out of 280 studies, 9 studies (1104 patients) were eligible...
March 19, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38500284/the-application-of-nanotechnological-therapeutic-platforms-against-gynecological-cancers
#22
JOURNAL ARTICLE
Vahideh Keyvani, Samaneh Mollazadeh, Espanta Riahi, Reihaneh Alsadat Mahmoudian, Masoomeh Tabari, Elmira Lagzian, Elnaz Ghorbani, Hamed Akbarzade, Amir-Sadra Gholami, Ibrahim Saeed Gataa, Seyed Mahdi Hassanian, Gordon A Ferns, Majid Khazaei, Amir Avan, Kazem Anvari
Gynecological cancers (GCs), ovarian, cervical, and endometrial/uterine cancers, are often associated with poor outcomes. Despite the development of several therapeutic modalities against GCs, the effectiveness of the current therapeutic approaches is limited due to their side effects, low therapeutic index, short halflife, and resistance to therapy. To overcome these limitations, nano delivery-based approaches have been introduced with the potential of targeted delivery, reduced toxicity, controlled release, and improved bioavailability of various cargos...
March 18, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38493419/current-practice-with-operative-hysteroscopy-for-fertility-preservation-in-endometrial-cancer-and-endometrial-premalignancies
#23
REVIEW
Esra Bilir, Joanna Kacperczyk-Bartnik, Nicolò Bizzarri, İlker Kahramanoğlu
PURPOSE: The primary aim was to analyze the current practices on the use of operative hysteroscopy for preserving fertility in patients diagnosed with endometrial cancer and premalignancies. Our secondary objectives included investigating medical therapy and analyzing reported pregnancy-related outcomes subsequent to fertility preservation procedures. METHODS: We performed a semi-systematic literature review on PubMed, employing pertinent terms related to hysteroscopy, fertility preservation, and endometrial cancer and premalignancies...
March 17, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38488586/the-role-and-challenges-of-regulating-endometrial-microbiome-in-uterine-health-and-diseases
#24
REVIEW
Chongshan Yuan, Kunyu Xie, Lianjun Feng, Shouyang Gao, Lifu Cai
The uterine environment provides necessary conditions for the existence of endometrial microbiota, which in turn plays an important role in maintaining the homeostasis of the uterine environment. The endometrial microbiome is highly susceptible to external factors such as age, hormones, menstrual, pregnancy, etc. When the microbiota is imbalanced, it will further promote the occurrence of uterine diseases such as endometritis and endometrial cancer. Regulating the microbiome of the endometrium is of positive significance for promoting uterine health...
March 15, 2024: Critical Reviews in Microbiology
https://read.qxmd.com/read/38487605/a-review-of-laparoscopic-para-aortic-lymphadenectomy-for-early-stage-endometrial-cancer-extraperitoneal-approach-may-have-the-advantage-over-intraperitoneal-approach
#25
REVIEW
Kazuaki Imai, Junko Hirooka-Nakama, Yuichiro Hotta, Hiroyuki Shigeta
The importance of lymphadenectomy, including para-aortic nodes, for the accurate staging of endometrial cancer, is well established. Although the therapeutic role of lymph node resection in endometrial cancer is still under debate, some studies support its usefulness for survival benefit. To predict the necessity of lymphadenectomy, several preoperative scoring systems have been proposed as being effective. For endometrial cancer, there is a trend towards minimally invasive surgery, including para-aortic lymphadenectomy...
2024: Gynecology and Minimally Invasive Therapy
https://read.qxmd.com/read/38479596/melatonin-current-evidence-on-protective-and-therapeutic-roles-in-gynecological-diseases
#26
REVIEW
Azam Hosseinzadeh, Nazila Alinaghian, Mohammad Sheibani, Farnoosh Seirafianpour, Ali Jamshidi Naeini, Saeed Mehrzadi
Melatonin, a potent antioxidant and free radical scavenger, has been demonstrated to be effective in gynecological conditions and female reproductive cancers. This review consolidates the accumulating evidence on melatonin's multifaceted protective effects in different pathological contexts. In gynecological conditions such as endometriosis, polycystic ovary syndrome (PCOS), and uterine leiomyoma, melatonin has shown promising effects in reducing oxidative stress, inflammation, and hormonal imbalances. It inhibits adhesion molecules' production, and potentially mitigates leukocyte adherence and inflammatory responses...
March 11, 2024: Life Sciences
https://read.qxmd.com/read/38479585/the-risk-of-breast-cancer-and-gynecologic-malignancies-after-ovarian-stimulation-meta-analysis-of-cohort-study
#27
REVIEW
Chuanju Chen, Hao Shi, Jingya Yang, Xiao Bao, Yingpu Sun
The effects of ovarian stimulation on breast and gynecological tumor incidence remain controversial. Therefore, the aim of this meta-analysis was to study the risk of cancer in ovarian stimulation. Of the 22713 studies initially identified, 28 were eligible for inclusion. The results revealed that the impact of ovarian cancer (RR = 1.33, [1.05; 1.69]) and cervical cancer (RR = 0.67, [0.46; 0.97]) is significant among the overall effects. In subgroup analysis, in the nulliparous population (RR = 0.81 [0.68; 0...
March 11, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38474808/polyphenols-influence-the-development-of-endometrial-cancer-by-modulating-the-gut-microbiota
#28
REVIEW
Ewa Baranowska-Wójcik, Anna Winiarska-Mieczan, Piotr Olcha, Małgorzata Kwiecień, Karolina Jachimowicz-Rogowska, Łukasz Nowakowski, Andrzej Miturski, Krzysztof Gałczyński
Dysbiosis of the microbiota in the gastrointestinal tract can induce the development of gynaecological tumours, particularly in postmenopausal women, by causing DNA damage and alterations in metabolite metabolism. Dysbiosis also complicates cancer treatment by influencing the body's immune response and disrupting the sensitivity to chemotherapy drugs. Therefore, it is crucial to maintain homeostasis in the gut microbiota through the effective use of food components that affect its structure. Recent studies have shown that polyphenols, which are likely to be the most important secondary metabolites produced by plants, exhibit prebiotic properties...
February 28, 2024: Nutrients
https://read.qxmd.com/read/38473385/recent-advances-in-endometrial-cancer-prevention-early-diagnosis-and-treatment
#29
REVIEW
Holly Baker-Rand, Sarah J Kitson
Endometrial cancer is the sixth commonest cancer in women worldwide, with over 417,000 diagnoses in 2020. The disease incidence has increased by 132% over the last 30 years and is set to continue to rise in response to an ageing population and increasing global rates of obesity and diabetes. A greater understanding of the mechanisms driving endometrial carcinogenesis has led to the identification of potential strategies for primary disease prevention, although prospective evaluation of their efficacy within clinical trials is still awaited...
March 1, 2024: Cancers
https://read.qxmd.com/read/38473344/exploring-the-potential-link-between-pfas-exposure-and-endometrial-cancer-a-review-of-environmental-and-sociodemographic-factors
#30
REVIEW
Aderonke Ayodele, Emmanuel Obeng-Gyasi
This exploratory narrative review paper delves into the intricate interplay between per- and polyfluoroalkyl substances (PFAS) exposure, sociodemographic factors, and the influence of stressors in the context of endometrial cancer. PFAS, ubiquitous environmental contaminants notorious for their persistence in the ecosystem, have garnered attention for their potential to disrupt endocrine systems and provoke immune responses. We comprehensively examine the various sources of PFAS exposure, encompassing household items, water, air, and soil, thus shedding light on the multifaceted routes through which individuals encounter these compounds...
February 28, 2024: Cancers
https://read.qxmd.com/read/38473283/predictive-value-of-magnetic-resonance-imaging-in-risk-stratification-and-molecular-classification-of-endometrial-cancer
#31
JOURNAL ARTICLE
Hanna Bae, Sung Eun Rha, Hokun Kim, Jun Kang, Yu Ri Shin
This study evaluated the magnetic resonance imaging (MRI) findings of endometrial cancer (EC) patients and identified differences based on risk group and molecular classification. The study involved a total of 175 EC patients. The MRI data were retrospectively reviewed and compared based on the risk of recurrence. Additionally, the associations between imaging phenotypes and genomic signatures were assessed. The low-risk and non-low-risk groups (intermediate, high-intermediate, high, metastatic) showed significant differences in tumor diameter ( p < 0...
February 25, 2024: Cancers
https://read.qxmd.com/read/38473276/atypical-endometrial-hyperplasia-and-concurrent-cancer-a-comprehensive-overview-on-a-challenging-clinical-condition
#32
REVIEW
Luca Giannella, Camilla Grelloni, Marco Bernardi, Camilla Cicoli, Federica Lavezzo, Gianmarco Sartini, Leonardo Natalini, Mila Bordini, Martina Petrini, Jessica Petrucci, Tomas Terenzi, Giovanni Delli Carpini, Jacopo Di Giuseppe, Andrea Ciavattini
The present review regarding atypical endometrial hyperplasia (AEH) focused on the main debated factors regarding this challenging clinical condition: (i) predictive variables of occult endometrial cancer (EC); (ii) the rate of EC underestimation according to different endometrial sampling methods; and (iii) the appropriateness of lymph node status assessment. When cancer is detected, approximately 90% of cases include low-risk EC, although intermediate/high-risk cases have been found in 10-13% of women with cancer...
February 24, 2024: Cancers
https://read.qxmd.com/read/38473269/diagnostic-accuracy-of-transvaginal-ultrasound-and-magnetic-resonance-imaging-for-the-detection-of-myometrial-infiltration-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#33
REVIEW
István Madár, Anett Szabó, Gábor Vleskó, Péter Hegyi, Nándor Ács, Péter Fehérvári, Tamás Kói, Emma Kálovics, Gábor Szabó
In endometrial cancer (EC), deep myometrial invasion (DMI) is a prognostic factor that can be evaluated by various imaging methods; however, the best method of choice is uncertain. We aimed to compare the diagnostic performance of two-dimensional transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) in the preoperative detection of DMI in patients with EC. Pubmed, Embase and Cochrane Library were systematically searched in May 2023. We included original articles that compared TVS to MRI on the same cohort of patients, with final histopathological confirmation of DMI as reference standard...
February 23, 2024: Cancers
https://read.qxmd.com/read/38473019/optimizing-palliative-pelvic-radiotherapy-in-gynecological-cancers-a-systematic-review-and-analysis
#34
REVIEW
Beatrice Anghel, Mihai-Teodor Georgescu, Crenguta Sorina Serboiu, Andreea Nicoleta Marinescu, Cătălin Aliuș, Dragoș-Eugen Georgescu, Bogdan Mocanu, Sabina Sucuri, Anca Daniela Stanescu
BACKGROUND: Palliative radiotherapy plays a crucial role in managing symptomatic gynecological cancers (GCs). This article aims to systematically review literature studies on palliative pelvic radiotherapy in cervical, endometrial, ovarian, vaginal, and vulvar cancers. The primary focus is centered around evaluating symptom relief, quality of life (QOL), and toxicity in order to ascertain optimal radiotherapy regimens. METHODOLOGY: For this thorough review, we mainly relied on Medline to gather papers published until November 2023...
March 5, 2024: Diagnostics
https://read.qxmd.com/read/38463556/the-clinical-and-pathological-characteristics-of-pole-mutated-endometrial-cancer-a-comprehensive-review
#35
REVIEW
Xiaohong Yao, Min Feng, Wei Wang
Endometrial cancer shows high histological and molecular heterogeneity. The POLE mutation is a significant molecular alteration in endometrial cancer, leading to the identification of a specific subtype known as POLE -mutated endometrial cancer. This subtype exhibits a high tumor mutation burden, abundant lymphocyte infiltration, and a favorable prognosis, making it a promising candidate for immune checkpoint inhibitor therapy. This paper presents a comprehensive review of the clinical and pathological characteristics, outcomes, treatment advancements, pathogenic POLE gene detection, and alternative testing methods for POLE -mutated endometrial cancer...
2024: Cancer Management and Research
https://read.qxmd.com/read/38463097/impact-of-artificial-intelligence-on-the-diagnosis-treatment-and-prognosis-of-endometrial-cancer
#36
REVIEW
Samia Rauf Butt, Amna Soulat, Priyanka Mohan Lal, Hajar Fakhor, Siddharth Kumar Patel, Mashal Binte Ali, Suneel Arwani, Anmol Mohan, Koushik Majumder, Vikash Kumar, Usha Tejwaney, Sarwan Kumar
Endometrial cancer is one of the most prevalent tumours in females and holds an 83% survival rate within 5 years of diagnosis. Hypoestrogenism is a major risk factor for the development of endometrial carcinoma (EC) therefore two major types are derived, type 1 being oestrogen-dependent and type 2 being oestrogen independent. Surgery, chemotherapeutic drugs, and radiation therapy are only a few of the treatment options for EC. Treatment of gynaecologic malignancies greatly depends on diagnosis or prognostic prediction...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38461683/therapeutic-effects-and-molecular-mechanisms-of-quercetin-in-gynecological-disorders
#37
REVIEW
Xian Jian, Chen Shi, Weichen Luo, Liyuan Zhou, Lili Jiang, Kuiran Liu
Quercetin is a representative flavonoid that is widely present in fruits, herbs, and vegetables. It is also an important active core component in traditional Chinese medicines. As an important flavonoid, quercetin has various properties and exerts antioxidant, anti-inflammatory, and cardioprotective effects. The public interest in quercetin is increasing, and quercetin has been used to prevent or treat numerous of diseases, such as polycystic ovary syndrome (PCOS), cancer, autoimmune diseases and chronic cardiovascular diseases, in clinical experiments and animal studies due to its powerful antioxidant properties and minimal side effects...
March 8, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38453533/percutaneous-interstitial-brachytherapy-ablation-for-targeting-oligometastatic-gynecologic-cancers
#38
JOURNAL ARTICLE
Tiffany S Lai, Alex Francoeur, Erica Manrriquez, Puja Venkat, Albert Chang, Michael Douek, Simin Bahrami, Steven S Raman, Sanaz Memarzadeh
INTRODUCTION: Treatment of recurrent oligometastatic gynecologic malignancy may involve targeted surgery, thermal ablation, or CT-guided high-dose-rate interstitial brachytherapy ablation (CT-HDR-IBTA). The purpose of this study was to describe the safety and efficacy of CT-HDR-IBTA for oligometastatic gynecologic malignancies. METHODS: With institutional review board approval (IRB) approval and compliance with the Health Insurance Portability and Accountability Act of 1996 (HIPAA) compliance, we searched our database to assemble a single-arm study cohort of all patients with oligometastatic gynecologic cancers who underwent CT-HDR-IBTA from 2012-2022 with follow-up...
March 6, 2024: Brachytherapy
https://read.qxmd.com/read/38453180/delivery-of-hereditary-cancer-genetics-services-to-patients-newly-diagnosed-with-ovarian-and-endometrial-cancers-at-three-gynecologic-oncology-clinics-in-the-usa-brazil-and-mexico
#39
JOURNAL ARTICLE
Erica M Bednar, Keiry A Paiz, Karen H Lu, Aline Patricia Soares Dias De Souza, Gabriela Oliveira, Carlos E Eduardo Mattos da Cunha Andrade, Lenny Gallardo, Jairo Rubio-Cordero, David Cantu-de-León, Jose Alejandro Rauh-Hain
OBJECTIVE: Three gynecologic oncology clinics located in the USA, Brazil, and Mexico collaborated to evaluate their delivery of hereditary cancer genetics services. This descriptive retrospective review study aimed to establish baseline rates and timeliness of guideline-recommended genetics service delivery to patients with ovarian, fallopian tube, primary peritoneal (ovarian), and endometrial cancers at each clinic. METHODS: Patients who were newly diagnosed with ovarian and endometrial cancers between September 1, 2018 and December 31, 2020 were identified from the medical records of the clinics...
March 6, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38452144/role-of-ultrasound-in-detection-of-lymph-nodes-metastasis-in-gynecological-cancers-systematic-review-and-meta-analysis
#40
REVIEW
A C Borges, H Veloso, P Galindo, A Danés, E Chacon, J A Mínguez, J L Alcázar
OBJECTIVE: To assess the diagnostic performance of transvaginal ultrasound (TVUS) for preoperative evaluation of lymph node metastasis in gynecological cancers. METHODS: A systematic review and meta-analysis was performed. All studies published between January 1990 to May 2023 evaluating the role of ultrasound for detecting lymph node metastasis (index test) in gynecological cancers, using histopathological analysis, as reference standard were included. Quality was assessed using QUADAS-2...
March 7, 2024: Ultrasound in Obstetrics & Gynecology
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