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endometrial cancer review

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https://www.readbyqxmd.com/read/28637507/dysregulated-expression-of-long-noncoding-rnas-in-gynecologic-cancers
#1
REVIEW
Elahe Seyed Hosseini, Matthieu Meryet-Figuiere, Hamed Sabzalipoor, Hamed Haddad Kashani, Hossein Nikzad, Zatollah Asemi
Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed to play a crucial role in several different biological processes, has made the regulation of gene expression more complex. Although the function of lncRNAs is still rather elusive, their broad involvement in the initiation and progression of various cancers is clear. They are also involved in the pathogenesis of cancers of the female reproductive system...
June 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28631718/-current-prerequisites-for-a-molecular-genetic-classification-of-endometrial-cancer
#2
S V Vtorushin, R D Malykh
The review analyzes current investigators' data on the introduction of an additional endometrial cancer classification based on the results of molecular and genetic studies. This necessity is dictated by clinical observations, according to which the genetic profile of the tumors may not correspond to their morphological structure, which considerably changes patient management tactics. The existing dualistic model of carcinogenesis makes it possible to identify and describe the characteristic molecular features of the tumors in terms of their histological structure...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28625396/management-of-menopausal-symptoms-in-women-with-gynecologic-cancers
#3
REVIEW
Marcela G Del Carmen, Laurel W Rice
OBJECTIVE: Women with gynecologic malignancies will be cured or may become long-term survivors. Management of menopausal symptoms is important in addressing their quality of life. We review the benefit and safety of hormone therapy use in these patients. METHODS: MEDLINE was searched for studies on menopause management published in English through December of 2016. RESULTS: Available data suggest that short-term use of hormone therapy in gynecologic cancer patients who do not have an estrogen-dependent malignancy do not adversely impact oncologic outcome and results in improvement of menopausal vasomotor and genitourinary symptoms...
June 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28614060/dietary-n-3-polyunsaturated-fatty-acids-fish-consumption-and-endometrial-cancer-risk-a-meta-analysis-of-epidemiological-studies
#4
Rui Hou, Shen-Shen Yao, Jia Liu, Lian-Lian Wang, Lang Wu, Luo Jiang
The relationship between intake of fish and n-3 fatty acids and endometrial cancer risk has not been consistent across epidemiological studies. We quantitatively assessed the aforementioned association through a systematic review and meta-analysis. PubMed and Embase were searched through March 2017 for eligible epidemiological studies. Fixed or random-effects models were used to pool relative risks (RRs) and 95% confidence intervals (CIs). The dose-response relationship was also evaluated. Based on the literature search, five prospective studies and 11 case-control studies were identified...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28613035/total-laparoscopic-hysterectomy-for-endometrial-cancer-in-a-renal-transplantation-patient-receiving-peritoneal-dialysis-case-report-and-literature-review
#5
Mamoru Kakuda, Eiji Kobayashi, Yusuke Tanaka, Yutaka Ueda, Kiyoshi Yoshino, Tadashi Kimura
Improved surgical techniques and immunosuppressant medications for organ transplantation have resulted in a significant increase in the number of women undergoing renal transplantation. Peritoneal dialysis (PD), a common supportive therapy for chronic renal failure, is also used in cases of renal transplantation failure. Herein, we report the first case of a rare total conventional laparoscopic gynecologic hysterectomy performed for endometrial cancer in a patient undergoing life-supportive PD as a result of renal transplantation failure...
June 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28609712/two-week-waits-what-are-we-waiting-for
#6
Ahmed R Abdelraheim, Mohammed Khairy, Mo'men Mohammed, Alexandra Lawrence
OBJECTIVES: To evaluate the two-week referral system by analysing the 2-week wait (2WW) referrals to the rapid access gynaecology clinic over one year. We have also sought to identify the risk factors for endometrial cancer to help setting criteria that can be used to prioritise urgent appointments, refine subsequent management strategies. STUDY DESIGN: Retrospective review of the data of all women referred for suspected gynaecological cancers over one year via the 2 WW office at Queen's Hospital, Romford, UK...
June 10, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28604454/the-significance-of-pretreatment-thrombocytosis-and-its-association-with-neutrophilia-in-patients-with-surgically-treated-endometrial-cancer
#7
Ryoko Takahashi, Seiji Mabuchi, Hiromasa Kuroda, Katsumi Kozasa, Eriko Yokoi, Yuri Matsumoto, Tadashi Kimura
OBJECTIVE: The aim of this study was to investigate the prognostic significance of a pretreatment thrombocytosis and its association with neutrophilia in patients with surgically treated endometrial cancer. METHODS: The baseline characteristics and outcome data of 508 patients with surgically treated endometrial cancer between January 2000 and December 2010 were collected and retrospectively reviewed. The patients were separated into 4 groups according to their platelet counts and the neutrophil counts, and the progression-free and overall survival rates of the 4 groups were compared...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604450/low-volume-lymph-node-metastases-in-endometrial-carcinoma
#8
Lani K Clinton, Jordan Kondo, Michael E Carney, Pamela Tauchi-Nishi, Keith Terada, David Shimizu
OBJECTIVE: The aim of this study was to determine the histopathologic characteristics of patients with endometrial carcinoma with low-volume metastases (micrometastases and isolated tumor cells) compared with macrometastases. METHODS: We performed a retrospective review of patients with endometrial carcinoma. RESULTS: Among 350 robotic-assisted hysterectomies for endometrial cancer, 187 (53%) underwent attempted sentinel lymph node (SLN) biopsy...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28566221/sentinel-lymph-node-mapping-and-staging-in-endometrial-cancer-a-society-of-gynecologic-oncology-literature-review-with-consensus-recommendations
#9
REVIEW
Robert W Holloway, Nadeem R Abu-Rustum, Floor J Backes, John F Boggess, Walter H Gotlieb, W Jeffrey Lowery, Emma C Rossi, Edward J Tanner, Rebecca J Wolsky
The emphasis in contemporary medical oncology has been "precision" or "personalized" medicine, terms that imply a strategy to improve efficacy through targeted therapies. Similar attempts at precision are occurring in surgical oncology. Sentinel lymph node (SLN) mapping has recently been introduced into the surgical staging of endometrial cancer with the goal to reduce morbidity associated with comprehensive lymphadenectomy, yet obtain prognostic information from lymph node status. The Society of Gynecologic Oncology's (SGO) Clinical Practice Committee and SLN Working Group reviewed the current literature for preparation of this document...
May 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28564635/a-high-plasma-d-dimer-level-predicts-poor-prognosis-in-gynecological-tumors-in-east-asia-area-a-systematic-review-and-meta-analysis
#10
Lei Xu, Fan He, Hongcai Wang, Bei Gao, Huini Wu, Shuping Zhao
High pre-treatment plasma D-dimer levels have been reported as a factor associated with a poor prognosis in different types of malignancies, including pancreatic, gastric, colorectal, lung, and nasopharyngeal carcinoma. Here, we performed a meta-analysis to determine the association of plasma D-dimer levels and long term survival in gynecological cancers, including ovarian, cervical and endometrial carcinoma. We searched all eligible publications in PubMed and Web of Science Databases up to August 2016. Primary outcomes, including overall survival (OS), disease-free survival and hazard ratios (HR) of were extracted and analyzed...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28562264/adult-consequences-of-self-limited-delayed-puberty
#11
REVIEW
Jia Zhu, Yee-Ming Chan
Delayed puberty is a common condition defined as the lack of sexual maturation by an age ≥2 SD above the population mean. In the absence of an identified underlying cause, the condition is usually self-limited. Although self-limited delayed puberty is largely believed to be a benign developmental variant with no long-term consequences, several studies have suggested that delayed puberty may in fact have both harmful and protective effects on various adult health outcomes. In particular, height and bone mineral density have been shown to be compromised in some studies of adults with a history of delayed puberty...
May 18, 2017: Pediatrics
https://www.readbyqxmd.com/read/28558116/sentinel-lymph-node-technique-in-endometrial-cancer
#12
Allison Staley, Stephanie A Sullivan, Emma C Rossi
Importance: Endometrial cancer (EMCA) is the most common gynecologic malignancy, with an estimated 54,000 new cases and 10,000 deaths in the United States in 2015. Lymph node metastasis is the most significant prognostic factor in EMCA. Sentinel lymph node (SLN) mapping has become a well-accepted procedure in surgical oncology and may strike a balance between the risks and benefits of lymphadenectomy. Objective: The aim of this study was to review the current literature regarding the history, techniques, and clinical application of SLN mapping in EMCA...
May 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28551932/-hormone-replacement-therapy-after-gynecological-malignancies
#13
REVIEW
Nadav Michaan, Dan Grisaru
Treatment of gynecological malignancies can cause an abrupt onset of menopausal symptoms along with associated long term morbidity. Hormone replacement therapy (HRT) is the most effective treatment to alleviate these symptoms but the safety of HRT among gynecologic oncology patients remains controversial. We conducted a review of the published literature on the risk of recurrent disease among gynecologic cancer patients using HRT. Our research revealed a shortage of prospective, randomized trials on this important subject...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28549791/micrornas-in-gynecological-cancers-small-molecules-with-big-implications
#14
Sanjeev K Srivastava, Aamir Ahmad, Haseeb Zubair, Orlandric Miree, Seema Singh, Rodney P Rocconi, Jennifer Scalici, Ajay P Singh
Gynecological cancers (GCs) are often diagnosed at advanced stages, limiting the efficacy of available therapeutic options. Thus, there remains an urgent and unmet need for innovative research for the efficient clinical management of GC patients. Research over past several years has revealed the enormous promise of miRNAs. These small non-coding RNAs can aid in the diagnosis, prognosis and therapy of all major GCs, viz., ovarian cancers, cervical cancers and endometrial cancers. Mechanistic details of the miRNAs-mediated regulation of multiple biological functions are under constant investigation, and a number of miRNAs are now believed to influence growth, proliferation, invasion, metastasis, chemoresistance and the relapse of different GCs...
May 24, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28547956/pap-smears-in-endometrial-adenocarcinoma-does-it-have-a-role
#15
Asma Nadaf, Hephzibah Rani, Parinitha S S, Ravikala Rao, Dinesh Shastri
Background: Historically the conventional Pap smear has been an effective screening tool for Carcinoma cervix. However the reporting of benign and malignant endometrial cells on Pap smear has remained controversial. There are very few studies addressing the utility of Pap smears in diagnosing endometrial carcinomas. Objective: To rescreen the Pap smears of patients with endometrial adenocarcinoma for the detection of normal/ atypical endometrial cells and to correlate with clinico-pathological parameters. Methods: The present study was carried out at SDM College of Medical Sciences, Dharwad, Karnataka, India for a period of 7 years...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28546787/pepsinogen-c-expression-regulation-and-its-relationship-with-cancer
#16
REVIEW
Shixuan Shen, Jingyi Jiang, Yuan Yuan
Pepsinogen C (PGC) belongs to the aspartic protease family and is secreted by gastric chief cells. PGC could be activated to pepsin C and digests polypeptides and amino acids, but as a zymogen PGC's functions is unclear. In normal physiological conditions, PGC is initially detected in the late embryonic stage and is mainly expressed in gastric mucosa. The in situ expression of PGC in gastric mucosa is decreased considerably in the process of superficial gastritis → atrophic gastritis → gastric cancer (GC), proving that PGC is a comparatively ideal negative marker of GC...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28545269/-risk-factors-of-endometriosis-associated-ovarian-carcinoma-in-women-aged-45-years-and-older
#17
Z X He, S Wang, Z F Li, L Zhu, J H Leng, J H Lang
Obiective: To explore the risk factors of endometriosis-associated ovarian cancer (EAOC) in women with ovarian endometriosis aged 45 years and older in China. Methods: The medical records of total 1 038 women aged 45 years and older with a surgicopathological diagnosis of ovarian endometriosis treated at Peking Union Medical College Hospital from December 1994 to December 2014 were reviewed. Histology evaluation determined ovarian endometriosis with (n=30) or without (n=1 008) ovarian cancer. Results: (1) There were 30 (2...
May 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28544572/inositol-treatment-of-anovulation-in-women-with-polycystic-ovary-syndrome-a-meta-analysis-of-randomised-trials
#18
Jyotsna Pundir, Dimitrios Psaroudakis, Prakash Savnur, Priya Bhide, Luca Sabatini, Helena Teede, Arri Coomarasamy, Shakila Thangaratinam
BACKGROUND: Polycystic ovary syndrome is a common cause of anovulation and infertility, and a risk factor for development of metabolic syndrome and endometrial cancer. OBJECTIVES: Systematic review and meta-analysis of randomised controlled trials that evaluated the effects of inositol as an ovulation-induction agent. SEARCH STRATEGY: We searched MEDLINE, EMBASE, Cochrane and ISI conference proceedings, Register and Meta-register for RCTs and WHO trials' search portal...
May 24, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28541629/adult-granulosa-cell-tumors-of-the-ovary-a-retrospective-study-of-30-cases-with-respect-to-the-expression-of-steroid-synthesis-enzymes
#19
Sachiko Kitamura, Kaoru Abiko, Noriomi Matsumura, Hidekatsu Nakai, Yumiko Akimoto, Hirotoshi Tanimoto, Ikuo Konishi
OBJECTIVE: Some, but not all, granulosa cell tumors are characterized by estrogen production. This study was designed to determine whether there are clinical or pathological variations in granulosa cell tumors in relation to the expression of sex steroid synthesis enzymes. METHODS: Clinical symptoms, serum hormonal values, and histology of 30 granulosa cell tumor patients who underwent surgery between 2002 and 2014 were retrospectively reviewed. RESULTS: Most patients presented with abnormal genital bleeding including abnormal menstrual cycles...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28539172/influence-of-aspirin-and-non-aspirin-nsaid-use-on-ovarian-and-endometrial-cancer-summary-of-epidemiologic-evidence-of-cancer-risk-and-prognosis
#20
REVIEW
F Verdoodt, S K Kjaer, S Friis
Increasing evidence supports a role for aspirin use in reducing the incidence and mortality of several cancer types. This has spurred a new wave of interest in this widely used drug. In this review, we present and evaluate the epidemiologic evidence of the association between the use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) and the incidence and prognosis of ovarian and endometrial cancer. The evidence of a preventive effect of NSAID use on risk of ovarian or endometrial cancer is based primarily on results from observational studies and, consequently, is only suggestive...
June 2017: Maturitas
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