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endometrial cancer review

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https://www.readbyqxmd.com/read/27904621/the-association-between-vitamin-d-and-health-outcomes-in-women-a-review-on-the-related-evidence
#1
REVIEW
Nahid Ramezani Jolfaie, Mohammad Hossein Rouhani, Shokouh Onvani, Leila Azadbakht
BACKGROUND: Vitamin D has a wide range of physiological functions in skeletal and nonskeletal tissues which may play a role in many diseases. The aim of this study was to evaluate the recent evidence regarding the effects of Vitamin D on several health outcomes in women including breast cancer, ovarian and endometrial cancers, hypertension, and osteoporosis. MATERIALS AND METHODS: We searched PubMed and Google Scholar databases through March 2016. We included the most current systematic reviews and meta-analyses assessing the associations of Vitamin D intake and/or serum 25-hydroxyvitamin D (25(OH)D) levels with the risk of incidence of breast cancer, ovarian and endometrial cancers, hypertension, and osteoporosis...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903150/addressing-the-role-of-obesity-in-endometrial-cancer-risk-prevention-and-treatment
#2
Michaela A Onstad, Rosemarie E Schmandt, Karen H Lu
In sharp contrast to many other cancer types, the incidence and mortality of endometrial cancer continue to grow. This unfortunate trend is, in no small part, a result of the worldwide obesity epidemic. More than half of endometrial cancers are currently attributable to obesity, which is recognized as an independent risk factor for this disease. In this review, we identify the molecular mechanisms by which obesity and adipose tissue contribute to the pathogenesis of endometrial cancer. We further discuss the impact of obesity on the clinical management of the disease and examine the development of rational behavioral and pharmaceutical interventions aimed at reducing endometrial cancer risk, improving cancer outcomes, and preserving fertility in an increasingly younger population of patients with endometrial cancer...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27903147/weight-loss-randomized-intervention-trials-in-female-cancer-survivors
#3
Rowan T Chlebowski, Marina M Reeves
Purpose Observational study evidence has associated overweight/obesity with decreased survival in women with breast cancer and with several other cancers. Although full-scale, definitive weight loss adjuvant intervention trials with cancer end points remain to be conducted, a number of randomized controlled trials have evaluated weight loss interventions in survivors of cancer in women. Findings from these trials in breast, endometrial, and ovarian cancer are reviewed. Methods A systematic review of randomized controlled clinical trials evaluating weight loss interventions was updated (for studies published 2013 to 2016), and clinical trials registers were searched for ongoing trials...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27899185/genetic-predisposition-in-gynecologic-cancers
#4
REVIEW
Molly S Daniels, Karen H Lu
This review article discusses the diagnosis and management of hereditary ovarian cancer and hereditary uterine cancer. The key recommendations highlighted are: All women with high grade non-mucinous epithelial ovarian cancer should be offered at least BRCA1 and BRCA2 genetic testing. The care of women with BRCA-associated ovarian cancer should be tailored to their mutation status. Risk-reducing bilateral salpingo-oophorectomy is recommended for women with BRCA1/2 mutations. Women with endometrial cancer should be assessed for the possibility of Lynch syndrome...
October 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/27894165/practice-guidelines-for-management-of-uterine-corpus-cancer-in-korea-a-korean-society-of-gynecologic-oncology-consensus-statement
#5
Shin Wha Lee, Taek Sang Lee, Dae Gy Hong, Jae Hong No, Dong Choon Park, Jae Man Bae, Seok Ju Seong, So Jin Shin, Woong Ju, Keun Ho Lee, Yoo Kyung Lee, Hanbyoul Cho, Chulmin Lee, Jiheum Paek, Hyun Jung Kim, Jeong Won Lee, Jae Weon Kim, Duk Soo Bae
OBJECTIVE: Clinical practice guidelines for gynecologic cancers have been developed by many organizations. Although these guidelines have much in common in terms of the practice of standard of care for uterine corpus cancer, practice guidelines that reflect the characteristics of patients and healthcare and insurance systems are needed for each country. The Korean Society of Gynecologic Oncology (KSGO) published the first edition of practice guidelines for gynecologic cancer treatment in late 2006; the second edition was released in July 2010 as an evidence-based recommendation...
October 27, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27871836/sentinel-lymph-node-assessment-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#6
REVIEW
Anna Jo Bodurtha Smith, Amanda Nickles Fader, Edward J Tanner
BACKGROUND: In the staging of endometrial cancer, controversy remains regarding the role of sentinel lymph node mapping compared with other nodal assessment strategies. OBJECTIVE: We conducted a systematic review to evaluate the diagnostic accuracy and clinical impact of sentinel lymph node mapping in the management of endometrial cancer. DATA SOURCES: We searched Medline, Embase, and the Cochrane Central Registry of Controlled trials for studies published in English before March 25, 2016 (PROSPERO CRD42016036503)...
November 18, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27870710/histopathology-discrepancy-of-preoperative-endometrial-sampling-and-final-specimen-how-does-this-influence-selective-lymph-node-dissection
#7
Bradley R Corr, Aakriti Carrubba, Jeanelle Sheeder, Georgina Cheng, Saketh R Guntupalli
OBJECTIVE: Preoperative histology is a major component in the perioperative selective lymph node (LN) dissection decision process. Discrepancy between preoperative endometrial sampling and final specimen histopathology is generally accepted. The goals of this project are to determine if discrepancy of histopathology is associated with alteration of adjuvant treatment or outcome. MATERIALS AND METHODS: We performed a retrospective cross-sectional analysis of all patients undergoing surgery for endometrial cancer at a single institution from 2010 to 2014...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27864117/microcystic-elongated-and-fragmented-melf-pattern-invasion-is-mainly-associated-with-isolated-tumor-cell-pattern-metastases-in-figo-grade-i-endometrioid-endometrial-cancer-eec
#8
Mathieu P Pelletier, Vincent Q Trinh, Philippe Stephenson, Anne-Marie Mes-Masson, Vanessa Samouelian, Diane M Provencher, Kurosh Rahimi
While many studies have evaluated the impact of mismatch repair protein loss of expression (MMR LOE) or microcystic, elongated and fragmented (MELF) pattern of myometrial invasion as individual factors in endometrial cancer, we analyzed the combined impact of both. We reviewed every case of FIGO grade 1 endometrioid endometrial cancers (EEC) from our institution, between 2011 and 2015, that had a sentinel lymph node biopsy and/or a lymphadenectomy, and examined the following data: age, myometrial infiltration, MELF infiltration, lymphovascular space invasion and lymph node status...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27861200/imaging-of-hereditary-tumors-of-the-female-genital-system
#9
Sarah M Rothan, Christine O Menias, Yehia M ElGuindy, Corey T Jensen, Akram Shaaban, Priya Bhosale, Michelle V Lee, Venkata S Katabathina, Khaled M Elsayes
Cancers of the female genital system, particularly endometrial and ovarian cancers, can be associated with hereditary cancer syndromes such as hereditary breast and ovarian cancer and Lynch syndrome. Cancers that are found in the setting of a hereditary cancer syndrome are often unique in presentation, clinical features, and pathologic profiles when compared with sporadic tumors. This article reviews the hereditary cancer syndromes associated with gynecological malignancies, as well as the imaging findings and staging system of endometrial and ovarian cancers...
November 17, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27855392/the-emerging-roles-of-long-noncoding-rna-ror-lincrna-ror-and-its-possible-mechanisms-in-human-cancers
#10
Yan Pan, Chen Li, Jing Chen, Kai Zhang, Xiaoyuan Chu, Rui Wang, Longbang Chen
To date, there is only up to 2% of protein-coding genes that are stably transcribed, whereas the vast majority are non-coding RNAs (ncRNAs). These ncRNAs, also known as non-messenger RNAs (nmRNAs) or functional RNAs (fRNAs), include transfer RNAs, ribosomal RNAs, microRNAs and long non-coding RNAs (lncRNAs). With the advance of high-resolution microarrays and massively parallel sequencing technology, lncRNAs have gained extended attentions nowadays and are found to play important roles in tumorigenesis and progression of human cancers...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27847479/understanding-molecular-landscape-of-endometrial-cancer-through-next-generation-sequencing-what-we-have-learned-so-far
#11
Siti-Syazani Suhaimi, Nurul-Syakima Ab Mutalib, Rahman Jamal
Endometrial cancer (EC) is among the most common gynecological cancers affecting women worldwide. Despite the early detection and rather high overall survival rate, around 20% of the cases recur with poor prognosis. The Next Generation Sequencing (NGS) technology, also known as massively parallel sequencing, symbolizes a high-throughput, fast, sensitive and accurate way to study the molecular landscape of a cancer and this has indeed revolutionized endometrial cancer research. Understanding the potential, advantages, and limitations of NGS will be crucial for the healthcare providers and scientists in providing the genome-driven care in this era of precision medicine and pharmacogenomics...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27835893/folate-intake-and-the-risk-of-endometrial-cancer-a-meta-analysis
#12
Li Du, Yulong Wang, Hang Zhang, Hong Zhang, Ying Gao
BACKGROUND: Folate may involve in various aspects of carcinogenesis. However, the relationship between folate intake and risk of many cancers, including endometrial cancer, is still inconclusive. We conducted a meta-analysis to systematically review the association. METHODS: Relevant studies were searched through three electronic databases (PubMed, Embase, and Web of Science) up to April 4, 2016. Population based prospective or case-control studies involving in investigating folate intake and risk of endometrial cancer were considered as eligible...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27831834/role-of-imaging-in-fertility-sparing-treatment-of-gynecologic-malignancies
#13
Andrea G Rockall, Mahrukh Qureshi, Ioanna Papadopoulou, Srdjan Saso, Nicholas Butterfield, Isabelle Thomassin-Naggara, Alan Farthing, J Richard Smith, Nishat Bharwani
Treatments for gynecologic cancer usually result in loss of fertility due to surgery or radical radiation therapy in the pelvis. In countries with an established screening program for cervical cancer, the majority of gynecologic malignancies occur in postmenopausal women. However, a substantial number of affected women are of childbearing age and have not completed their families. In these younger women, consideration of fertility preservation may be important. This article describes the fertility-sparing treatment options that are currently available and outlines the role of imaging in the selection of eligible patients on the basis of a review of the literature...
November 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27817223/discovery-of-biomarkers-for-endometrial-cancer-current-status-and-prospects
#14
Tea Lanišnik Rižner
Endometrial cancer is the most frequent gynecological malignancy in the developed world. Currently, endometrial histology is the gold standard for diagnosis, as there are no valid noninvasive diagnostic methods available. Biomarkers for endometrial cancer would be invaluable for screening of high-risk women, detection of primary and recurrent disease, and preoperative stratification of patients as high-risk and low-risk categories, enabling personalized therapeutic approaches. Areas covered: This report reviews publications of blood biomarkers evaluated in patients with endometrial cancer and/or control patients, over the last five years...
December 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27817040/female-infertility-infertility-associated-diagnoses-and-comorbidities-a-review
#15
REVIEW
Brent Hanson, Erica Johnstone, Jessie Dorais, Bob Silver, C Matthew Peterson, James Hotaling
PURPOSE: The purpose of the study is to evaluate existing literature for possible associations between female infertility, infertility-associated diagnoses, and the following areas of disease: psychiatric disorders, breast cancer, ovarian cancer, endometrial cancer, cardiovascular disease, and metabolic dysfunction. METHODS: The design of the study is a literature review. The patients were women included in 26 selected studies due to a diagnosis of infertility or a reproductive disorder associated with infertility...
November 5, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27812904/clinical-comparison-of-robotic-laparoscopic-and-open-hysterectomy-procedures-for-endometrial-cancer-patients
#16
Lynette Johnson, W Douglas Bunn, Loan Nguyen, Jessica Rice, Minakshi Raj, Mary J Cunningham
The goal of this study was to compare outcomes for robotic, laparoscopic, and open hysterectomy procedures for endometrial cancer as well as to investigate whether specific patient demographic, comorbidity, and severity variables were associated with the type of hysterectomy performed. A retrospective review was conducted of hysterectomy procedures for patients discharged from October 1, 2008 and September 30, 2012. Preoperative characteristics included age, BMI, number of past abdominal surgeries, and comorbidities...
November 3, 2016: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/27812854/sentinel-lymph-node-mapping-in-patients-with-stage-i-endometrial-carcinoma-a-focus-on-bilateral-mapping-identification-by-comparing-radiotracer-tc99-m-with-blue-dye-versus-indocyanine-green-fluorescent-dye
#17
Andrea Papadia, Ignacio Zapardiel, Beatrice Bussi, Fabio Ghezzi, Marcello Ceccaroni, Elena De Ponti, Federica Elisei, Sara Imboden, Begoña Diaz de la Noval, Maria Luisa Gasparri, Giampaolo Di Martino, Javier De Santiago, Michael Mueller, Francesca Vecchione, Federica Dell'Orto, Alessandro Buda
PURPOSE: The aim of this study was to compare technetium radiocolloid (Tc99(m)) + blue dye (BD) versus Indocyanine green (ICG) fluorescent dye in terms of the overall detection rate and bilateral sentinel lymph node (SLN) mapping in patients with endometrial carcinoma. METHODS: Patients from five European centers with apparently confined clinical stage I endometrial cancer were reviewed. A comparison was made between women who received SLN mapping with pelvic and/or aortic lymphadenectomy (LND), and women who underwent SLN algorithm (SA), was also performed between the two groups...
November 3, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27810073/the-emerging-role-of-long-non-coding-rnas-in-endometrial-cancer
#18
REVIEW
Konii Takenaka, Bei Jun Chen, Susan C Modesitt, Frances L Byrne, Kyle L Hoehn, Michael Janitz
The human genome is pervasively transcribed and approximately 98% of the genome is non-coding. Long non-coding RNAs (lncRNAs) are a heterogeneous group of RNA transcripts that are >200 nucleotides in length with minimal to no protein-coding potential. Similar to proteins, lncRNAs have important biological functions in both normal cells and disease states including many types of cancer. This review summarizes recent advances in our understanding of lncRNAs in cancer biology and highlights the potential for lncRNA as diagnostic biomarkers and therapeutics...
October 2016: Cancer Genetics
https://www.readbyqxmd.com/read/27803603/serum-carcinoembryonic-antigen-as-a-tumour-marker-in-patients-with-endometrial-cancer
#19
Y Hashiguchi, M Kasai, T Fukuda, T Ichimura, T Yasui, T Sumi
BACKGROUND: No potential tumour markers have been validated for prognosis in endometrial cancer. However, carcinoembryonic antigen (cea) is one of the most widely used tumour markers in various types of cancer. Although cea expression in endometrial cancer has been investigated, its prognostic value remains controversial, and no studies have investigated serum cea levels in large case series. In the present study, we investigated diagnostic and prognostic applications of serum cea for endometrial cancer...
October 2016: Current Oncology
https://www.readbyqxmd.com/read/27784171/physiopathological-factors-affecting-the-diagnostic-value-of-serum-he4-test-for-gynecologic-malignancies
#20
Wanglei Qu, Jinping Li, Ping Duan, Zuoqing Tang, Fengbiao Guo, Haibin Chen, Xueqiong Zhu, Shi-Wen Jiang
Serum epididymis protein 4 (HE4) represents a useful biomarker for the management of ovarian cancer and endometrial cancer patients. However, HE4 levels are affected by many physiopathological conditions or disorders that should be taken into consideration for an efficient application of this biomarker. Areas covered: The review provides an up-to-date reference on the multiple physiopathological factors that cause fluctuation of HE4 serum levels, and evaluates their impact on HE4-test in clinical settings. Potential mechanisms underlying the regulation of HE4 expression are also discussed...
November 17, 2016: Expert Review of Molecular Diagnostics
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