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endometrial cancer review

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https://www.readbyqxmd.com/read/29163851/checkpoint-inhibitors-in-endometrial-cancer-preclinical-rationale-and-clinical-activity
#1
REVIEW
Gloria Mittica, Eleonora Ghisoni, Gaia Giannone, Massimo Aglietta, Sofia Genta, Giorgio Valabrega
Context: Treatment of advanced and recurrent endometrial cancer (EC) is still an unmet need for oncologists and gynecologic oncologists. The Cancer Genome Atlas Research Network (TCGA) recently provided a new genomic classification, dividing EC in four subgroups. Two types of EC, the polymerase epsilon (POLE)-ultra-mutated and the microsatellite instability-hyper-mutated (MSI-H), are characterized by a high mutation rate providing the rationale for a potential activity of checkpoint inhibitors...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29158911/a-retrospective-evaluation-of-activity-of-gemcitabine-platinum-regimens-in-the-treatment-of-recurrent-ovarian-cancer
#2
Tran N Le, Rachel E Harvey, Christine K Kim, Jubilee Brown, Robert L Coleman, Judith A Smith
Background: While many of these agents have been compared in prospective clinical trials, the gemcitabine/platinumbased regimens have not been compared in a prospective, randomized clinical trial. While bothgemcitabine/carboplatin and gemcitabine/cisplatin have a similar ORR in separate clinical trials, the tworegimens have never been directly been compared. With overlapping dose-limiting toxicity of thrombocytopenia, the gemcitabine/carboplatin regimen has been challenging to employ in the clinical setting in previously treated ovarian cancer patients and is often associated with treatment delays and/or dose reductions...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/29150143/life-after-endometrial-cancer-a-systematic-review-of-patient-reported-outcomes
#3
Robert Shisler, Jennifer A Sinnott, Vivian Wang, Courtney Hebert, Ritu Salani, Ashley S Felix
BACKGROUND: Women with endometrial cancer (EC) are the second largest population of female cancer survivors in the United States. However, the outcomes of EC survivors, from the patient perspective, are not well-understood. Therefore, we conducted a systematic review of patient-reported outcomes (PROs) following an EC diagnosis. METHODS: We searched MEDLINE, EMBASE, Scopus, CINAHL, and reference lists to identify published observational studies that examined PROs among women with EC...
November 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29146752/physical-activity-and-cancer-an-umbrella-review-of-the-literature-including-22-major-anatomical-sites-and-770%C3%A2-000-cancer-cases
#4
REVIEW
Leandro Fórnias Machado de Rezende, Thiago Hérick de Sá, Georgios Markozannes, Juan Pablo Rey-López, I-Min Lee, Konstantinos K Tsilidis, John P A Ioannidis, José Eluf-Neto
OBJECTIVE: To provide an overview of the breadth and validity of claimed associations between physical activity and risk of developing or dying from cancer. DESIGN: Umbrella review. DATA SOURCES: We searched Medline, Embase, Cochrane Database and Web of Science. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Systematic reviews about physical activity and cancer incidence and cancer mortality in different body sites among general population...
November 16, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29137450/moving-forward-with-actionable-therapeutic-targets-and-opportunities-in-endometrial-cancer-nci-clinical-trials-planning-meeting-report-on-identifying-key-genes-and-molecular-pathways-for-targeted-endometrial-cancer-trials
#5
REVIEW
Helen J MacKay, Douglas A Levine, Victoria L Bae-Jump, Daphne W Bell, Jessica N McAlpine, Alessandro Santin, Gini F Fleming, David G Mutch, Kenneth P Nephew, Nicolas Wentzensen, Paul J Goodfellow, Oliver Dorigo, Hans W Nijman, Russell Broaddus, Elise C Kohn
The incidence and mortality rates from endometrial cancer are increasing. There have been no new drugs approved for the treatment of endometrial cancer in decades. The National Cancer Institute, Gynecologic Cancer Steering Committee identified the integration of molecular and/or histologic stratification into endometrial cancer management as a top strategic priority. Based on this, they convened a group of experts to review the molecular data in this disease. Here we report on the actionable opportunities and therapeutic directions identified for incorporation into future clinical trials...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132875/aspirin-use-and-endometrial-cancer-risk-and-survival
#6
REVIEW
Tsuyoshi Takiuchi, Erin A Blake, Koji Matsuo, Anil K Sood, Theodore M Brasky
The role of acetylsalicylic acid (aspirin) as a chemo-preventive and adjuvant therapeutic agent for cancers is generating attention. Mounting evidence indicates that aspirin reduces the incidence and mortality of certain obesity-related cancers, particularly colorectal cancer. In endometrial cancer, previous studies examining the effect of aspirin remain inconsistent as to the reduction in the risk of endometrial cancer. While some evidence indicates protective effects in obese women, other studies have showed a potential deleterious effect of these medications on endometrial cancer outcomes...
November 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29132772/-primary-management-of-endometrial-carcinoma-joint-recommendations-of-the-french-society-of-gynecologic-oncology-sfog-and-of-the-french-college-of-obstetricians-and-gynecologists-cngof
#7
D Querleu, E Darai, F Lecuru, A Rafii, E Chereau, P Collinet, P Crochet, H Marret, E Mery, L Thomas, V Villefranque, A Floquet, F Planchamp
OBJECTIVES: The management of endometrial carcinoma is constantly evolving. The SFOG and the CNGOF decided to jointly update the previous French recommendations (Institut national du cancer 2011) and to adapt to the French practice the 2015 recommendations elaborated at the time of joint European consensus conference with the participation of the three concerned European societies (ESGO, ESTRO, ESMO). MATERIAL AND METHODS: A strict methodology was used. A steering committee was put together...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29127647/o-glcnacylation-in-women-s-cancers-breast-endometrial-and-ovarian
#8
REVIEW
Gloria M Trinca, Christy R Hagan
O-GlcNAcylation is emerging as a critical regulatory post-translational modification, impacting proteins that regulate cell division, apoptosis, metabolism, cell signaling, and transcription. O-GlcNAc also affects biological homeostasis by integrating information coming from the environment, such as nutrient conditions and extracellular stimuli, with cellular response. Aberrant O-GlcNAc modulation has been linked to metabolic and neurodegenerative diseases, as well as cancers. While many studies have highlighted the significance of O-GlcNAc in cancer, a specific function for O-GlcNAc during tumorigenesis remains unclear and seems to differ according to cancer type...
November 10, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29115416/annexin-a2-and-cancer-a-systematic-review
#9
Maria V Christensen, Claus K Høgdall, Kirsten M Jochumsen, Estrid V S Høgdall
Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in cancer progression. The present review aimed to show the relations between Annexin A2 and cancer. A systematic search for studies investigating cancer and Annexin A2 expression was conducted using PubMed. Acute lymphoblastic leukaemia, acute promyelocytic leukaemia, clear cell renal cell carcinoma, breast, cervical, colorectal, endometrial, gastric cancer, glioblastoma, hepatocellular carcinoma, lung, multiple myeloma, oesophageal squamous cell carcinoma, ovarian cancer, pancreatic duct adenocarcinoma, prostate cancer and urothelial carcinoma were evaluated...
November 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29113037/vitamin-d-and-vdr-in-gynecological-cancers-a-systematic-review
#10
REVIEW
Eileen Deuster, Udo Jeschke, Yao Ye, Sven Mahner, Bastian Czogalla
In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. In this review, we systematically analyzed the effect of vitamin D and the vitamin D receptor on endometrial, ovarian, cervical, vulvar and vaginal cancer. Our literature research shows that vitamin D levels and vitamin-D-related pathways affect the risk of gynecological cancers...
November 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29105030/what-s-new-in-imaging-for-gynecologic-cancer
#11
REVIEW
Sairah R Khan, Mubarik Arshad, Kathryn Wallitt, Victoria Stewart, Nishat Bharwani, Tara D Barwick
Magnetic resonance imaging (MRI) is the optimal modality for local staging of gynecological tumors. Advances in functional MRI with diffusion-weighted and dynamic contrast-enhanced sequences provide more detailed information regarding tumor cellularity, vascularity, and viability. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) now has an established role in imaging for gynecological cancers, particularly staging of locally advanced cervical cancers and pre-salvage exenterative therapy in relapsed gynecologic tumors...
November 6, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/29100604/-clinical-trials-and-perspectives-of-radiotherapy-for-uterine-endometrial-cancers
#12
REVIEW
Cyrus Chargari, Pierre Maroun, Ioana Lazarescu, Christine Haie-Meder
The adjuvant management of uterine endometrial cancer has been studied in many randomized trials, leading to define postoperative therapeutic indications, depending on the risk factors for relapse, and on the expected benefit in terms of locoregional control and survival. The potential toxicity of treatments should be also considered. We review the available literature that yielded to guidelines that were recently published, on behalf of European societies, and we highlight the perspectives on ongoing studies, aimed at better defining the place and type of adjuvant treatment...
October 31, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29096350/endometrioid-adenocarcinoma-originating-simultaneously-from-endometrium-sites-of-adenomyosis-and-ovarian-endometriosis-a-case-report-and-review-of-our-cancer-database
#13
Lena Tashima, Kensuke Hori, Hitomi Ono, Teruaki Nagano, Shin-Ichi Nakatsuka, Kimihiko Ito
INTRODUCTION: Although adenomyosis is a common disease, it is a relatively rare site for cancer origin. On the other hand, chocolate cysts have the potential to develop into cancer. We report a case of endometrioid adenocarcinoma occurred at three sites simultaneously; uterine endometrium, adenomyosis and ovarian endometriosis. PRESENTATION OF CASE: A 51-year-old woman underwent total hysterectomy and bilateral salpingo-oophorectomy after a diagnosis of corpus cancer (endometrioid adenocarcinoma, G1) stage IA...
October 30, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29093822/ezh2-inhibition-in-arid1a-mutated-clear-cell-and-endometrioid-ovarian-and-endometrioid-endometrial-cancers
#14
REVIEW
Jill K Alldredge, Ramez N Eskander
Clear cell carcinoma and endometrioid adenocarcinoma are histologic subtypes of ovarian and uterine cancer that demonstrate unique clinical behavior but share common underlying genomic aberrations and oncogenic pathways. ARID1A mutations are more frequently identified in these tumors, in comparison to other gynecologic histologies, and loss of ARID1A tumor suppressor function is thought to be an essential component of carcinogenic transformation. Several therapeutic targets in ARID1A mutated cancers are in development, including EZH2 inhibitors...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/29079464/retroperitoneal-lumboaortic-lymphadenectomy-using-vessel-sealing-device-in-10-steps
#15
Marie Schaub, Lise Lecointre, Emilie Faller, Thomas Boisramé, Arnaud Wattiez, Jean-Jacques Baldauf, Cherif Akladios
STUDY OBJECTIVE: Describe the surgical technique of laparoscopic retroperitoneal lumboaortic lymphadenectomy using vessel-sealing device in 10 steps DESIGN: Educative video (Canadian Task Force Classification III) SETTING: Tertiary referral center in Strasbourg, France. The local institutional review board approved the video. BACKGROUND: Lumboaortic lymphadenectomy is frequently performed in the surgical management of different gynaecologic pelvic malignancies: cervical endometrial and ovarian cancer...
October 24, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29077194/metformin-for-endometrial-hyperplasia
#16
REVIEW
Naomi S Clement, Thomas Rw Oliver, Hunain Shiwani, Juliane Rf Sanner, Caroline A Mulvaney, William Atiomo
BACKGROUND: Endometrial cancer is one of the most common gynaecological cancers in the world. Rates of endometrial cancer are rising, in part because of rising obesity rates. Endometrial hyperplasia is a precancerous condition in women that can lead to endometrial cancer if left untreated. Endometrial hyperplasia occurs more commonly than endometrial cancer. Progesterone tablets currently used to treat women with endometrial hyperplasia are associated with adverse effects in up to 84% of women...
October 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29076388/effects-of-theory-based-behavioral-interventions-on-physical-activity-among-overweight-and-obese-female-cancer-survivors-a-systematic-review-of-randomized-controlled-trials
#17
Amerigo Rossi, Ciarán Friel, Leeja Carter, Carol Ewing Garber
PURPOSE: To determine whether theory-based physical activity (PA) interventions for overweight and obese female cancer survivors lead to increased PA and improved health. METHODS: This systematic review examined randomized controlled trials analyzing the impact of theory-based PA interventions on overweight and obese female cancer survivors through December 2016. Searches of 5 electronic databases revealed 10 articles that included 1351 participants who met the inclusion criteria...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29074629/obesity-and-gynaecological-and-obstetric-conditions-umbrella-review-of-the-literature
#18
REVIEW
Ilkka Kalliala, Georgios Markozannes, Marc J Gunter, Evangelos Paraskevaidis, Hani Gabra, Anita Mitra, Vasso Terzidou, Phillip Bennett, Pierre Martin-Hirsch, Konstantinos K Tsilidis, Maria Kyrgiou
Objective To study the strength and validity of associations between adiposity and risk of any type of obstetric or gynaecological conditions.Design An umbrella review of meta-analyses.Data sources PubMed, Cochrane database of systematic reviews, manual screening of references for systematic reviews or meta-analyses of observational and interventional studies evaluating the association between adiposity and risk of any obstetrical or gynaecological outcome.Main outcomes Meta-analyses of cohort studies on associations between indices of adiposity and obstetric and gynaecological outcomes...
October 26, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29072180/clinicopathologic-and-survival-results-in-serous-endometrium-carcinoma-and-subgroup-analysis-for-mixed-serous-and-pure-serous-histology
#19
Alpaslan Kaban, Samet Topuz, Hamdullah Sözen, Yağmur Minareci, Yavuz Salihoğlu
OBJECTIVE: To review theclinicopathologic and survival outcomes of the patients with serous endometrial cancer (EC) andto investigate subgroup analysis based on pure serous and mixed serous EC subtypes Material and Methods: Patients who had undergone EC surgery between 2002 and 2014 and who were reported as serous EC were enrolled in the study. All patients were diagnosed with serous endometrial cancer or mixed serous endometrial cancer with serous component higher than 10% based on the postoperative pathology report Results: A total of 93 patients were analyzed...
October 26, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29072178/relationships-of-nuclear-architectural-and-figo-grading-systems-in-endometrial-cancer
#20
Tayfun Toptaş, Elif Peştereli, Selen Bozkurt, Gülgün Erdoğan, Tayup Şimşek
OBJECTIVE: To examine correlations among nuclear, architectural and FIGO grading systems, and their relationships with lymph node (LN) involvement in endometrioid endometrial cancer. MATERIAL AND METHODS: Histopathology slides of 135 consecutive patients were reviewed with respect to tumor grade and LN metastasis. Notable nuclear atypia was defined as grade 3 nuclei. FIGO grade was established by raising the architectural grade (AG) by one grade when the tumor is composed of cells with nuclear grade (NG) 3...
October 26, 2017: Journal of the Turkish German Gynecological Association
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