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Lichen amyloidosis

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https://www.readbyqxmd.com/read/27828646/primary-localized-cutaneous-amyloidosis-with-lichen-and-poikiloderma-like-lesions-and-an-excellent-response-to-systemic-acitretin
#1
Han Ma, Xiangyang Su, Guoxing Zhu, Songchao Yin, Chun Lu, Wei Lai
Primary localized cutaneous amyloidosis is a skin-limited amyloidosis that does not involve internal organs. It is clinically subclassified into 3 general categories and some rare variants. However, there is considerable overlap within the classification. Though there are a variety of therapeutic measures, the treatment is often unsatisfactory, particularly when the disease is severe and extensive. We describe a rare case of primary localized cutaneous amyloidosis with lichen and poikiloderma-like lesions that showed an excellent response to systemic acitretin...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27613297/dermoscopy-in-general-dermatology-a-practical-overview
#2
REVIEW
Enzo Errichetti, Giuseppe Stinco
Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. dermatoses presenting with erythematous-desquamative patches/plaques (plaque psoriasis, eczematous dermatitis, pityriasis rosea, mycosis fungoides and subacute cutaneous lupus erythematosus), papulosquamous/papulokeratotic dermatoses (lichen planus, pityriasis rosea, papulosquamous sarcoidosis, guttate psoriasis, pityriasis lichenoides chronica, classical pityriasis rubra pilaris, porokeratosis, lymphomatoid papulosis, papulosquamous chronic GVHD, parakeratosis variegata, Grover disease, Darier disease and BRAF-inhibitor-induced acantholytic dyskeratosis), facial inflammatory skin diseases (rosacea, seborrheic dermatitis, discoid lupus erythematosus, sarcoidosis, cutaneous leishmaniasis, lupus vulgaris, granuloma faciale and demodicidosis), acquired keratodermas (chronic hand eczema, palmar psoriasis, keratoderma due to mycosis fungoides, keratoderma resulting from pityriasis rubra pilaris, tinea manuum, palmar lichen planus and aquagenic palmar keratoderma), sclero-atrophic dermatoses (necrobiosis lipoidica, morphea and cutaneous lichen sclerosus), hypopigmented macular diseases (extragenital guttate lichen sclerosus, achromic pityriasis versicolor, guttate vitiligo, idiopathic guttate hypomelanosis, progressive macular hypomelanosis and postinflammatory hypopigmentations), hyperpigmented maculopapular diseases (pityriasis versicolor, lichen planus pigmentosus, Gougerot-Carteaud syndrome, Dowling-Degos disease, erythema ab igne, macular amyloidosis, lichen amyloidosus, friction melanosis, terra firma-forme dermatosis, urticaria pigmentosa and telangiectasia macularis eruptiva perstans), itchy papulonodular dermatoses (hypertrophic lichen planus, prurigo nodularis, nodular scabies and acquired perforating dermatosis), erythrodermas (due to psoriasis, atopic dermatitis, mycosis fungoides, pityriasis rubra pilaris and scabies), noninfectious balanitis (Zoon's plasma cell balanitis, psoriatic balanitis, seborrheic dermatitis and non-specific balanitis) and erythroplasia of Queyrat, inflammatory cicatricial alopecias (scalp discoid lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia and folliculitis decalvans), nonscarring alopecias (alopecia areata, trichotillomania, androgenetic alopecia and telogen effluvium) and scaling disorders of the scalp (tinea capitis, scalp psoriasis, seborrheic dermatitis and pityriasis amiantacea)...
December 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27558615/generation-of-an-induced-pluripotent-stem-cell-line-from-a-patient-with-hereditary-multiple-endocrine-neoplasia-2a-men2a-syndrome-with-ret-mutation
#3
J Hadoux, O Féraud, F Griscelli, P Opolon, D Divers, E Gobbo, M Schlumberger, A Bennaceur-Griscelli, A G Turhan
Multiple Endocrine Neoplasia Type 2A (MEN2A) is a cancer-predisposing syndrome that affects patients with germline RET mutations. The clinical spectrum of the syndrome includes medullary thyroid carcinoma (MTC), pheochromocytoma, hyperparathyroidism and cutaneous lichen amyloidosis (CLA) and/or Hirschsprung disease in some variants. Currently, there is no satisfactory animal model recapitulating all the features of the disease especially at the level of stem cells. We generated induced pluripotent stem cells (iPSCs) from a patient with RET mutation at codon 634 who developed pheochromocytoma and MTC...
June 27, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/26984345/treatment-of-primary-cutaneous-amyloidosis-with-laser-a-review-of-the-literature
#4
REVIEW
Rand S Al Yahya
Primary cutaneous amyloidosis (PCA) is a condition characterized by tissue deposition of misfolded proteins. PCA can present in different forms, namely macular, lichen, and nodular amyloidosis. These lesions can be of cosmetic concern and are difficult to treat. Many therapeutic modalities have been suggested for the treatment of PCA, with variable efficacy, including topical and systemic medications, phototherapy, electrodessication, dermabrasion, cryosurgery, and lasers. Over the past decade, several studies have reported successful treatment of PCA with different types of lasers; however, a review of these studies has never been reported in the dermatologic literature...
July 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/26920351/men-2a-related-cutaneous-lichen-amyloidosis-report-of-three-kindred-and-systematic-literature-review-of-clinical-biochemical-and-molecular-characteristics
#5
Jessica Oliboni Scapineli, Lucieli Ceolin, Márcia Khaled Puñales, José Miguel Dora, Ana Luiza Maia
Multiple endocrine neoplasia type 2A (MEN2A) may be rarely associated with cutaneous lichen amyloidosis (CLA), a skin lesion located in the interescapular region. Here, we describe 3 MEN2A-related CLA kindred and perform a systematic review (SR) of the literature on clinical, biochemical and molecular characteristics of MEN2A-related CLA patients. Thirty-eight patients with MEN2A-related CLA followed at our institution were evaluated. The median age at MEN2A diagnosis in our cohort was 25 (13-41) years, 68 % were women and all harbored codon 634 RET mutations...
October 2016: Familial Cancer
https://www.readbyqxmd.com/read/26793847/the-autoimmune-constellation-in-lichen-amyloidosis
#6
Elena Andrese, D Vâţă, Delia Ciobanu, Laura Stătescu, Laura Gheucă Solovăstru
Localized cutaneous amyloidosis is a rare disease among white people, being more common in South-Asia, China and South America. The disease is characterized by deposition of amyloid material in the papillary dermis without visceral involvement. Nevertheless, there is a growing list of immune-mediated disorders that have been linked to cutaneous amyloidosis. We present two cases of concomitant occurrence of lichen amyloidosis and autoimmune thyroiditis/atopic dermatitis in two Caucasian women.
October 2015: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/26494387/hereditary-medullary-thyroid-cancer-genotype-phenotype-correlation
#7
REVIEW
Karin Frank-Raue, Friedhelm Raue
During the last two decades, there has been a marked expansion of our knowledge of both the basic and clinical aspects of multiple endocrine neoplasia type 2 (MEN2). There are two clinically distinct types of MEN2 syndrome, termed MEN2A and MEN2B. Within MEN2A, there are four variants: (i) classical MEN2A, represented by the uniform presence of MTC and the less frequent occurrence of pheochromocytoma, or primary hyperparathyroidism, or both; (ii) MEN2A with cutaneous lichen amyloidosis; (iii) MEN2A with Hirschsprung's disease; and (iv) familial medullary thyroid carcinoma (FMTC), i...
2015: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/26438242/genotype-phenotype-correlation-in-indian-patients-with-men2-associated-pheochromocytoma-and-comparison-of-clinico-pathological-attributes-with-apparently-sporadic-adrenal-pheochromocytoma
#8
COMPARATIVE STUDY
Sendhil Rajan, Ghazala Zaidi, Gaurav Agarwal, Anjali Mishra, Amit Agarwal, Saroj Kanta Mishra, Eesh Bhatia
INTRODUCTION: Pheochromocytoma (PCC) manifests in up to 50% of MEN2 patients. We correlated the clinico-pathological features of MEN2-associated PCC (MEN-PCC) with RET mutations and compared them with non-MEN adrenal-PCCs. METHODS: In this retrospective single institution study on a large PCC database (n = 208, 1997-2014) 24 MEN-PCC patients with known RET mutations were reviewed. Excluding 7 with incomplete data, the study cohort of 17 MEN-PCC patients from 11 kindreds (M:F::7:10) was identified...
March 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/26356818/ret-mutation-p-s891a-in-a-chinese-family-with-familial-medullary-thyroid-carcinoma-and-associated-cutaneous-amyloidosis-binding-osmr-variant-p-g513d
#9
Xiao-Ping Qi, Jian-Qiang Zhao, Zhen-Guang Chen, Jin-Lin Cao, Juan Du, Nai-Fang Liu, Feng Li, Mao Sheng, Er Fu, Jian Guo, Hong Jia, Yi-Ming Zhang, Ju-Ming Ma
There are no reports on the relationship between familial medullary thyroid carcinoma (FMTC) associated with cutaneous amyloidosis (CA) and RET or OSMR/IL31RA gene mutations. In this study, we investigated a Chinese family with FMTC/CA and found a recurrent RET c.2671T>G (p.S891A) mutation in six of 17 family members. Three of the six p.S891A mutation carriers presented with medullary thyroid carcinoma (MTC). Of them, three (two with and one without MTC) were diagnosed as having combined lichen/macular biphasic CA...
October 20, 2015: Oncotarget
https://www.readbyqxmd.com/read/25946210/efficacy-of-different-modes-of-fractional-co2-laser-in-the-treatment-of-primary-cutaneous-amyloidosis-a-randomized-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
Samia M Esmat, Marwa M Fawzi, Heba I Gawdat, Heba S Ali, Safinaz S Sayed
BACKGROUND: Primary cutaneous amyloidosis (PCA) comprises three main forms: macular, lichen, and nodular amyloidosis. The current available treatments are quite disappointing. OBJECTIVES: Assess and compare the clinical and histological changes induced by different modes of Fractional CO2 laser in treatment of PCA. PATIENTS AND METHODS: Twenty five patients with PCA (16 macular and 9 lichen amyloidosis) were treated by fractional CO2 using; superficial ablation (area A) and deep rejuvenation (area B)...
July 2015: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/25771782/fractional-1-550-nm-ytterbium-erbium-fiber-laser-in-the-treatment-of-lichen-amyloidosis-clinical-and-histological-study
#11
Ratchathorn Panchaprateep, Sai Tusgate, Girish S Munavalli, Nopadon Noppakun
BACKGROUND AND OBJECTIVE: Lichen amyloidosis is characterized by amyloid deposition in the papillary dermis, presenting clinically with intensely pruritic hyperkeratotic papules. Various treatment modalities have been used but the results are generally unsatisfactory. Several studies show that non-ablative fractional lasers can be used to treat depositional diseases due to their capability of inducing transepidermal elimination of the dermal content. To investigate the efficacy and safety of a non-ablative fractional 1,550 nm Yttrium/Erbium fiber laser for the treatment of lichen amyloidosis...
March 2015: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/25657431/bullous-variant-of-familial-biphasic-lichen-amyloidosis-a-unique-combination-of-three-rare-presentations
#12
Vijayalaxmi Veerabasappa Suranagi, Bs Siddramappa, Hema Basappa Bannur, Prakash V Patil, Reshma S Davangeri
A 55-year-old man presented with multiple, itchy papules and macules on the trunk and extremities. Histopathologic examination of biopsy specimens taken from three different lesions showed a subepidermal blister with amyloid deposits in the dermal papillae. No systemic disease or involvement of other organs was detected. The clinical and histological findings were compatible with a bullous variant of lichen amyloidosis (LA). Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions...
January 2015: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/25593815/response-to-oral-acitretin-in-lichen-amyloidosis
#13
Resham J Vasani
We report the therapeutically challenging case of a patient with severe and extensive lichen amyloidosis (LA) who responded to oral acitretin and topical corticosteroids. Colloid milia and terra firma-forme dermatoses were noted post healing of the lesions of LA. There has been no recurrence of lesions post 8 months of follow-up. We recommend that acitretin should be used more often in severe and recalcitrant cases of LA.
December 2014: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/25586447/oral-primary-localized-amyloidosis-in-hiv-infected-patients-the-oral-face-of-a-described-skin-lesion
#14
Gabriela Anaya-Saavedra, Velia Ramírez-Amador, Pedro Valencia-Mayoral
Oral primary localized amyloidosis should be considered in the diagnosis of oral white lesions such as hyperplastic candidosis, lichen planus and lichenoid reactions; it is not associated with antiretroviral therapy use, systemic involvement or malignant transformation.
December 2015: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/25566895/epidermolysis-bullosa-pruriginosa-a-case-with-a-novel-mutation-and-co-existent-lichen-amyloidosus
#15
Qiping Chen, Joyce Siong-See Lee, Hong Liang Tey
Epidermolysis bullosa pruriginosa is a rare variant of dystrophic epidermolysis bullosa characterized by severely pruritic and cicatricial lesions localized to the extensor extremities. We report a Singaporean Chinese male with epidermolysis bullosa pruriginosa with an underlying novel mutation in the COL7A1 gene. A heterozygous acceptor splice site mutation IVS67-1G>T probably led to in-frame skipping of exon 68 (36-basepairs), resulting in a loss of 12 amino acids. Among his three children, only the youngest son, who had bilateral big toenail thickening, possessed the same mutation...
January 2015: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/25272550/an-alternative-treatment-model-the-combination-therapy-of-narrow-band-ultraviolet-b-phototherapy-and-tacrolimus-ointment-0-1-in-biphasic-amyloidosis
#16
Göknur Kalkan, Fatma Markoç, Yalçin Bas
Primary localized cutaneous amyloidosis (PLCA) is caused by the extracellular deposition of amyloid material in the skin without other cutaneous or systemic organ involvement. PCLA is classified into lichen, macular,and nodular amyloidosis. Macular amyloidosis and lichen amyloidosis are named as biphasic amyloidosis when they are concurrently seen in a patient. The treatment of this disease is insufficient,even if there are several alternatives for treatment. Here we present a case of biphasic amyloidosis that responded well to topical tacrolimus ointment 0...
May 2014: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/25149547/localized-amyloidosis-of-the-vulva-with-and-without-vulvar-intraepithelial-neoplasia-report-of-a-series
#17
M Ruhul Quddus, C James Sung, Rochelle A Simon, W Dwayne Lawrence
Localized primary cutaneous amyloidosis is uncommon in Europe and North America and is infrequently reported in the English literature. The constituents of such deposits have not been previously examined; this series characterizes amyloid deposits in localized vulvar amyloidosis and their association with vulvar intraepithelial neoplasia. All biopsies and excisions of vulva over 18 months were reviewed. Cases with suspected amyloidosis were retrieved after institutional review board approval. Twenty cases mimicking amyloidosis were selected as controls...
October 2014: Human Pathology
https://www.readbyqxmd.com/read/24780569/-skin-disorders-associated-with-monoclonal-gammopathies
#18
REVIEW
C J Karin Houtman, Roel E Genders, Peter A von dem Borne, Maarten H Vermeer
A monoclonal gammopathy is a condition in which a monoclonal immunoglobulin (M-protein, formerly known as paraprotein) produced by a clonal proliferation of plasma cells is present in the blood. The spectrum of monoclonal gammopathies includes monoclonal gammopathy of uncertain significance (MGUS), multiple myeloma, Waldenström disease, plasmacytoma and primary amyloidosis. Various skin diseases are associated with monoclonal gammopathies. These are often rare skin diseases which are not easily recognised...
2014: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/24703261/successful-treatment-of-lichen-amyloidosis-using-a-co2-surgical-laser
#19
Osamu Norisugi, Takako Yamakoshi, Tadamichi Shimizu
Lichen amyloidosis (LA) is a type of primary localized cutaneous amyloidosis characterized by multiple pruritic discrete hyperkeratotic papules with amyloid deposition in the papillary dermis. Two patients with LA had been treated with topical corticosteroids, but with no effect on the eruptions. The present authors then started treating the affected area by superficial ablation using a CO2 surgical laser (LASER 30C, Lumenis Inc., Yokneum, Israel) at a setting of 10-15 watts with a 0.12-second pulse duration, 0...
March 2014: Dermatologic Therapy
https://www.readbyqxmd.com/read/24573820/a-th2-cytokine-interleukin-31-signature-in-a-case-of-sporadic-lichen-amyloidosis
#20
Léa Dousset, Julien Seneschal, Katia Boniface, Sandrine Charreau, Khaled Ezzedine, Brigitte Milpied, Mohammad D Mossalayi, John A McGrath, Jean Claude Lecron, Alain Taïeb
No abstract text is available yet for this article.
February 2015: Acta Dermato-venereologica
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