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https://www.readbyqxmd.com/read/29793057/ellagic-acid-protects-from-myelin-associated-sphingolipid-loss-in-experimental-autoimmune-encephalomyelitis
#1
Rebeca Busto, Jorge Serna, Aránzazu Perianes-Cachero, Rocío Quintana-Portillo, David García-Seisdedos, Alberto Canfrán-Duque, Carlos L Paino, Milagros Lerma, María E Casado, Antonia Martín-Hidalgo, Eduardo Arilla-Ferreiro, Miguel A Lasunción, Óscar Pastor
Experimental autoimmune encephalomyelitis (EAE), the most common model for multiple sclerosis, is characterized by inflammatory cell infiltration into the central nervous system and demyelination. Previous studies have demonstrated that administration of some polyphenols may reduce the neurological alterations of EAE. In this work, we show that ellagic acid, a polyphenolic compound, is beneficial in EAE, most likely through stimulation of ceramide biosynthesis within the brain. EAE was induced in Lewis rats by injection of guinea-pig spinal cord tissue along with Freund's complete adjuvant containing Mycobacterium tuberculosis...
May 21, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29791798/non-natural-linker-configuration-in-2-6-dipeptidyl-anthraquinones-enhances-the-inhibition-of-tar-rna-binding-annealing-activities-by-hiv-1-nc-and-tat-proteins
#2
Alice Sosic, Irene Saccone, Caterina Carraro, Thomas Kenderdine, Elia Gamba, Giuseppe Caliendo, Angela Corvino, Ferdinando Fiorino, Paola DiVaio, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Beatrice Severino, Valentina Spada, Daniele Fabris, Francesco Frecentese, Barbara Gatto
The HIV-1 nucleocapsid (NC) protein represents an excellent molecular target for the development of antiretrovirals by virtue of its well-characterized chaperone activities, which play pivotal roles in essential steps of the viral life cycle. Our ongoing search for candidates able to impair NC binding/annealing activities led to the identification of peptidyl-anthraquinones as a promising class of nucleic acid ligands. Seeking to elucidate the inhibition determinants and increase the potency of this class of compounds, we have now explored the effects of chirality in the linker connecting the planar nucleus to the basic side chains...
May 23, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29790769/synthesis-of-1-2-3-triazines-using-the-base-mediated-cyclization-of-z-2-4-diazido-2-alkenoates
#3
Hideyuki Sugimura, Reika Takeuchi, Shiori Ichikawa, Eri Nagayama, Ikuo Sasaki
A highly efficient and convenient method for the synthesis of 6-aryl-1,2,3-triazine-4-carboxylate esters has been developed using readily accessible ( Z)-4-aryl-2,4-diazido-2-alkenoates. This reaction is performed under mildly basic conditions without the assistance of any transition metals or strong acid.
May 23, 2018: Organic Letters
https://www.readbyqxmd.com/read/29790765/metal-template-assisted-proximal-arrangement-of-a-nucleophile-and-an-electrophile-site-selective-acylation-of-%C3%AE-hydroxyamides-in-polyols
#4
Yasuhiro Nishikawa, Kohei Takemoto, Kana Matsuda, Risa Tanaka, Akira Arashima, Kanako Ito, Yuki Kamezawa, Yuna Hori, Osamu Hara
Site-selective acylation of α-hydroxyl groups in amides has been achieved in the presence of other primary hydroxyl groups with intrinsic high reactivity. In this methodology, a relatively stable pyridine aldoxime ester was exploited as an acyl donor to suppress undesired acylation. The catalytic activation of a pyridine aldoxime ester with a Lewis acid produced a cationic complex, which preferentially attracted the Lewis basic α-hydroxyamide via a template effect, to thus facilitate o-acylation.
May 23, 2018: Organic Letters
https://www.readbyqxmd.com/read/29789171/n-propyl-n-2-pyridylurea-modified-silica-as-mixed-mode-stationary-phase-with-moderate-weak-anion-exchange-capacity-and-ph-dependent-surface-charge-reversal
#5
Stefanie Bäurer, Stefan Polnick, Orlando L Sánchez-Muñoz, Markus Kramer, Michael Lämmerhofer
Herein, we present a novel silica-based stationary phase modified with N-propyl-N'-2-pyridylurea selector. Due to the weakly basic properties of the pyridine selector and the presence of residual silanols after selector immobilization, a zwitterionic surface with a pI observed at approximately pH 5.5 was measured by electrophoretic light scattering in pH-dependent ζ-potential determinations. The capability of the new N-propyl-N'-2-pyridylurea-modified silica to serve as mixed-mode stationary phase was investigated...
May 7, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29786860/effect-of-cold-plasma-on-maintaining-the-quality-of-chub-mackerel-scomber-japonicus-biochemical-and-sensory-attributes
#6
Jing Chen, Sheng-Zhe Wang, Jun-Yu Chen, Dong-Zhi Chen, Shang-Gui Deng, Bin Xu
BACKGROUND: Atmospheric cold plasma (ACP) has emerged as a potential alternative to traditional methods for non-thermal food decontamination. However, little data are available about ACP treatment for seafood. In this study, dielectric barrier discharge (DBD) was applied to generate CP, and the aim of the study was to investigate the effectiveness of DBD-ACP on improving the quality of chub mackerel on the basis of chemical, microbial, and sensory characteristics. RESULTS: The effect of DBD-ACP on the quality of chub mackerel (Scomber japonicus) during storage was examined...
May 21, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29784335/gas-phase-complexation-of-%C3%AE-%C3%AE-cyclodextrin-with-amino-acids-studied-by-ion-mobility-mass-spectrometry-and-molecular-dynamics-simulations
#7
Yinjuan Chen, Zhicheng Zuo, Xinhua Dai, Peng Xiao, Xiang Fang, Xuefeng Wang, Wenning Wang, Chuan-Fan Ding
Cyclodextrins (CDs) are a class of macrocyclic molecules that have exhibited many promising applications in various fields. The knowledge of the complexation modes and recognition mechanisms of CDs with their guests are of paramount importance for rational design of more variants with controlled properties. Herein we investigated the binding conformations and the structural characteristics of α-/β-CD with three amino acids (AA, AA=Gly, L-Leu, L-Phe) in the gas phase by a combined experimental and computational approach...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783694/adaptive-mutations-in-influenza-a-california-07-2009-enhance-polymerase-activity-and-infectious-virion-production
#8
Patrick D Slaine, Cara MacRae, Mariel Kleer, Emily Lamoureux, Sarah McAlpine, Michelle Warhuus, André M Comeau, Craig McCormick, Todd Hatchette, Denys A Khaperskyy
Mice are not natural hosts for influenza A viruses (IAVs), but they are useful models for studying antiviral immune responses and pathogenesis. Serial passage of IAV in mice invariably causes the emergence of adaptive mutations and increased virulence. Here, we report the adaptation of IAV reference strain A/California/07/2009(H1N1) (also known as CA/07) in outbred Swiss Webster mice. Serial passage led to increased virulence and lung titers, and dissemination of the virus to brains. We adapted a deep-sequencing protocol to identify and enumerate adaptive mutations across all genome segments...
May 18, 2018: Viruses
https://www.readbyqxmd.com/read/29783152/functionalized-graphene-oxides-for-drug-loading-release-and-delivery-of-poorly-water-soluble-anticancer-drug-a-comparative-study
#9
Neha Karki, Himani Tiwari, Mintu Pal, Alok Chaurasia, Rajaram Bal, Penny Joshi, Nanda Gopal Sahoo
In this work, the modification of graphene oxides (GOs) have been done with hydrophilic and biodegradable polymer, polyvinylpyrrolidone (PVP) and other excipient β -cyclodextrin (β-CD) through covalent functionalization for efficient loading and compatible release of sparingly water soluble aromatic anticancer drug SN-38 (7-ethyl-10-hydroxy camptothecin). The drug was loaded onto both GO-PVP and GO-β-CD through the π-π interactions.The release of drug from both the nanocarriers were analyzed in different pH medium of pH 7 (water, neutral medium), pH 5 (acidic buffer) and pH 12 (basic buffer)...
May 18, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29782919/animal-models-to-study-bile-acid-metabolism
#10
REVIEW
Jianing Li, Paul A Dawson
The use of animal models, particularly genetically modified mice, continues to play a critical role in studying the relationship between bile acid metabolism and human liver disease. Over the past 20 years, these studies have been instrumental in elucidating the major pathways responsible for bile acid biosynthesis and enterohepatic cycling, and the molecular mechanisms regulating those pathways. This work also revealed bile acid differences between species, particularly in the composition, physicochemical properties, and signaling potential of the bile acid pool...
May 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29782167/potent-and-highly-selective-inhibitors-of-the-proteasome-trypsin-like-site-by-incorporation-of-basic-side-chain-containing-amino-acid-derived-sulfonyl-fluorides
#11
Raik Artschwager, David Ward, Susan Gannon, Arwin J Brouwer, Helmus van de Langemheen, Hubert Kowalski, Rob Liskamp
A unique category of basic side chain containing amino acid derived sulfonyl fluorides (SFs) has been synthesized for incorporation into new proteasome inhibitors targeting the trypsin-like site of the 20S proteasome. Masking the former α-amino functionality of the amino acid starting derivatives as an azido functionality, allowed an elegant conversion to the corresponding amino acid derived sulfonyl fluorides. The inclusion of different SFs at the P1 site of a proteasome inhibitor resulted in 14 different peptido sulfonyl fluorides (PSFs) having a high potency and an excellent selectivity for the proteolytic activity of the β2 subunit over that of the β5 subunit...
May 21, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29781252/subtype-selective-inhibition-of-acid-sensing-ion-channel-3-by-a-natural-flavonoid
#12
Xiao-Gang Yan, Wei-Guang Li, Xin Qi, Jia-Jie Zhu, Chen Huang, Shao-Ling Han, Qin Jiang, Tian-Le Xu, Jian-Hua Liu
AIMS: Acid-sensing ion channels (ASICs) are extracellular proton-gated cation channels that have been implicated in multiple physiological and pathological processes, and peripheral ASIC3 prominently participate into the pathogenesis of chronic pain, itch, and neuroinflammation, which necessitates the need for discovery and development of novel modulators in a subtype-specific manner. METHODS: Whole-cell patch clamp recordings and behavioral assays were used to examine the effect of several natural compounds on the ASIC-mediated currents and acid-induced nocifensive behavior, respectively...
May 20, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29779476/the-enthalpy-entropy-compensation-phenomenon-limitations-for-the-use-of-some-basic-thermodynamic-equations
#13
Sergei Khrapunov
The thermodynamic analyses of proteins, protein-ligands and protein-nucleic acid complexes involves the entropy-enthalpy (S-H) compensation phenomenon. We have examined the question whether the observed compensation is artificial or reflects anything more than the well-known laws of statistical thermodynamics (so-called extra-thermodynamic compensation). We have shown that enthalpy-entropy compensation (EEC) is mainly the trivial consequence of the basic thermodynamic laws and there are no experimental evidences for existence of the extra-thermodynamic compensation...
May 20, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29778710/some-structural-aspects-of-ammeline-keto-preference-and-dimerization
#14
Masashi Hatanaka
Subtle tautomerism in ammeline is clarified by means of IR- and UV-spectroscopic measurements and DFT calculations. While the enol form is narrowly preferred as an isolated molecule, dimerization of the keto form is plausible in solid phase due to double hydrogen bonds. In aqueous solutions, the keto form is proved to be more stable than the enol form due to the large electric dipole moment of the peptide group. The keto preference is also consistent with the acidity and basicity of the related heterocycles...
May 17, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29777706/n-3-polyunsaturated-fatty-acids-ameliorate-hepatic-steatosis-via-the-ppar-%C3%AE-cpt-1%C3%AE-pathway-in-a-mouse-model-of-parenteral-nutrition
#15
Feng Tian, Jiwei Wang, Haifeng Sun, Jianbo Yang, Peng Wang, Songlin Wan, Xuejin Gao, Li Zhang, Jieshou Li, Xinying Wang
Parenteral nutrition (PN) is one of the basic therapies for patients with intestinal failure; however, hepatic steatosis associated with PN limits the long-term use of PN. N-3 polyunsaturated fatty acids (PUFAs) have been used to improve clinical outcomes of patients receiving PN; however, the mechanisms by which n-3 PUFAs ameliorate hepatic steatosis remain unclear. In the present study, C57BL/6J mice were randomly assigned to three treatment groups, namely, enteral nutrition (EN), n-3 PUFAs, and n-6 PUFAs...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29777615/tools-for-work-up-and-pre-purification-of-tritium-labelled-small-molecules
#16
Dieter Muri, Martin R Edelmann
This practitioner protocol describes the use and application of different types of solid phase extractions and metal scavengers for small scale reactions, particularly in the context of purifying tritiated molecules from heavily contaminated reaction mixtures. Polymer-bound strong cation exchangers are especially suitable for separating basic compounds from neutral or acidic molecules and have been widely applied in the work-up of Iridium-based hydrogen isotope exchange reactions. Polymer-bound strong anion exchangers can help to separate acidic compounds from their neutral or basic counterparts or to easily convert a TFA or formate salt to its free base after HPLC purification...
May 19, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29777414/altered-gut-microbiota-associated-with-intestinal-disease-in-grass-carp-ctenopharyngodon-idellus
#17
Ngoc Tuan Tran, Jing Zhang, Fan Xiong, Gui-Tang Wang, Wen-Xiang Li, Shan-Gong Wu
Gut microbiota plays a crucial importance in their host. Disturbance of the microbial structure and function is known to be associated with inflammatory intestinal disorders. Enteritis is a significant cause of high mortality in fish species, including grass carp (Ctenopharyngodon idellus). Study regarding the association between microbial alternations and enteritis in grass carp is still absent. In this study, changes in the gut microbiota of grass carp suffering from enteritis were investigated using NGS-based 16S rRNA sequencing...
May 18, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29775316/l-arginine-catalyzed-synthesis-of-nanometric-organosilica-particles-through-a-waterborne-sol-gel-process-and-their-porous-structure-analysis
#18
Xiaoguang Qiao, Pierre-Yves Dugas, Laurent Veyre, Elodie Bourgeat-Lami
We report an efficient and easy to implement waterborne sol-gel process for the synthesis of nanometric organosilica particles. In this process, tetraethyl orthosilicate (TEOS) and 3-(methacryloxy)propyl trimethoxy silane (γ-MPS), employed as silica sources, are heterogeneously delivered in an aqueous solution of L-arginine, a basic amino acid used as catalyst, from a top organic layer. Co-condensation of TEOS with γ-MPS led to organosilica particles with diameters comprised between 30 and 230 nm when increasing the γ-MPS content from 0 to 10...
May 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29774871/-progression-of-basic-research-clinical-application-of-photodynamic-therapy-and-fluorescence-guided-surgery-in-glioma-treatment
#19
Xuegang Li, Hua Feng, Fei Li
The prognosis of glioma remains poor because of the infiltrative nature and the high local relapse rate. The current goals for patients with gliomas is maximal safe resection and adjuvant therapy. Tumor-specific photosensitizer, such as hematoporphyrin derivative (HpD) 5-aminolevulinic acid (5-ALA), can be selective up-taken and accumulated in tumor tissue. Light with appropriate wavelength can penetrate tumor tissue and excite the photosensitizer. The excited photosensitizer within glioma cells permits fluorescence visualization of tumor tissue during surgery and has been introduced in treatment of glioma as fluorescence-guided surgery (FGS)...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29774560/high-resolution-separation-of-monoclonal-antibodies-mixtures-and-their-charge-variants-by-an-alternative-and-generic-cze-method
#20
Alexandre Goyon, Yannis Nicolas Francois, Olivier Colas, Alain Beck, Jean Luc Veuthey, Davy Guillarme
The determination of mAb critical quality attributes (CQA) is crucial for their successful application in health diseases. A generic CZE method was developed for the high-resolution separation of various mAb charge variants, which are often recognized as important CQA. A dynamic coating of the capillary was obtained with polyethylene oxide (PEO), whereas Bis-Tris allowed the analysis of mAbs under native conditions at pH 7.0. The effect of PEO and Bis-Tris concentrations, as well as the nature of the acidic counter ion on the method performance were systematically studied...
May 17, 2018: Electrophoresis
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