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https://www.readbyqxmd.com/read/28214630/ph-and-reduction-dual-responsive-dipeptide-cationic-lipids-with-%C3%AE-tocopherol-hydrophobic-tail-for-efficient-gene-delivery
#1
Qiang Liu, Rong-Chuan Su, Wen-Jing Yi, Li-Ting Zheng, Shan-Shan Lu, Zhi-Gang Zhao
A series of tocopherol-based cationic lipid 3a-3f bearing a pH-sensitive imidazole moiety in the dipeptide headgroup and a reduction-responsive disulfide linkage were designed and synthesized. Acid-base titration of these lipids showed good buffering capacities. The liposomes formed from 3 and co-lipid 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) could efficiently bind and condense DNA into nanoparticles. Gel binding and HPLC assays confirmed the encapsulated DNA could release from lipoplexes 3 upon addition of 10 mM glutathione (GSH)...
February 12, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28214519/detection-and-quantification-of-soil-transmitted-helminths-in-environmental-samples-a-review-of-current-state-of-the-art-and-future-perspectives
#2
REVIEW
Isaac Dennis Amoah, Gulshan Singh, Thor Axel Stenström, Poovendhree Reddy
It is estimated that over a billion people are infected with soil-transmitted helminths (STHs) globally with majority occurring in tropical and subtropical regions of the world. The roundworm (Ascaris lumbricoides), whipworm (Trichuris trichiura), and hookworms (Anclostoma duodenale and Necator americanus) are the main species infecting people. These infections are mostly gained through exposure to faecally contaminated water, soil or contaminated food and with an increase in the risk of infections due to wastewater and sludge reuse in agriculture...
February 15, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28214380/application-of-the-mechpeff-model-to-predict-passive-effective-intestinal-permeability-in-the-different-regions-of-the-rodent-small-intestine-and-colon
#3
D Pade, M Jamei, A Rostami-Hodjegan, D B Turner
A major component of Physiologically-Based Pharmacokinetic (PBPK) models is prediction of the rate and extent of absorption of orally dosed drugs for which knowledge of effective passive intestinal permeability (Peff ) is essential. Single pass intestinal perfusion (SPIP) studies are used to establish effective permeability in vivo but are difficult to perform in rodents while mechanistic models to predict drug Peff in rat and mouse have not been published. This work evaluates the predictive performance of the 'MechPeff' model to predict Peff in the rodent intestine based upon knowledge of regional gut physiology and drug-specific physicochemical parameters...
February 18, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28213898/nuclear-localization-of-a-putative-phytophthora-sojae-bzip1-transcription-factor-is-mediated-by-multiple-targeting-motifs
#4
Yufeng Fang, Brett M Tyler
Oomycetes are fungal-like eukaryotic microbes in the kingdom Stramenopila. We recently found that the oomycete plant pathogen Phytophthora sojae uses nuclear localization signals (NLSs) for translocation of proteins into the nucleus that differ from conventional well-characterized NLSs from mammals and yeast. Here we have characterized in depth the nuclear localization signals of a P. sojae basic leucine zipper transcription factor, PsbZIP1. Nuclear localization of PsbZIP1 was determined by a central conserved region overlapping the DNA binding domain...
February 18, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28213514/peripheral-membrane-interactions-boost-the-engagement-by-an-anti-hiv-1-broadly-neutralizing-antibody
#5
Edurne Rujas, José M M Caaveiro, Sara Insausti, Miguel García-Porras, Kouhei Tsumoto, José L Nieva
The 4E10 antibody displays an extreme breadth of HIV-1 neutralization and therefore constitutes a suitable model system for structure- guided vaccine design and immunotherapeutics against AIDS. In this regard, the relevance of auto- reactivity with membrane lipids for the biological function of this antibody is still a subject of controversy. To address this dispute, herein we have compared the membrane-partitioning ability of the 4E10 antibody and several of its variants, which were mutated at the region of the paratope surface in contact with the membrane-interface...
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28213253/sensitive-kinetic-catalytic-spectrophotometric-method-for-cobalt-determination-using-a-chip-coupled-to-a-multisyringe-flow-injection-analysis-system
#6
Fatima Zohra Abouhiat, Camelia Henríquez, Farida El Yousfi, Víctor Cerdà
The development of an automated kinetic-catalytic spectrophotometric method for cobalt determination is presented. The method is based on the catalytic effect of Co in the oxidation of hydroxybenzoic acid by H2O2 in basic media. The method has been automated using a multisyringe flow injection system coupled to a monolithic flow conduit called chip (chip-MSFIA). All reagents and sample are simultaneously propelled into the chip to achieve an efficient mixing. The reaction product is monitored at 482nm. The reaction takes place very fast at room temperature, thus the fixed-time method is applied to quantify Co concentration in samples...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213089/monoglyceride-lipase-as-a-drug-target-at-the-crossroads-of-arachidonic-acid-metabolism-and-endocannabinoid-signaling
#7
REVIEW
Gernot F Grabner, Robert Zimmermann, Rudolf Schicho, Ulrike Taschler
Monoglyerides (MGs) are short-lived, intermediary lipids deriving from the degradation of phospho- and neutral lipids, and monoglyceride lipase (MGL), also designated as monoacylglycerol lipase (MAGL), is the major enzyme catalyzing the hydrolysis of MGs into glycerol and fatty acids. This distinct function enables MGL to regulate a number of physiological and pathophysiological processes since both MGs and fatty acids can act as signaling lipids or precursors thereof. The most prominent MG species acting as signaling lipid is 2-arachidonoylglycerol (2-AG) which is the most abundant endogenous agonist of cannabinoid receptors in the body...
February 14, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28211689/a-stable-porphyrin-based-porous-mog-metal-organic-framework-as-an-efficient-solvent-free-catalyst-for-c-c-bond-formation
#8
Wei Jiang, Jin Yang, Ying-Ying Liu, Shu-Yan Song, Jian-Fang Ma
We herein report the porous 4-fold interpenetrated mog (moganite) metal-organic framework (MOF) [Cd3(tipp)(bpdc)2]·DMA·9H2O (1·Cd; H2tipp = 5,10,15,20-tetrakis(4-(imidazol-1-yl)phenyl)porphyrin, H2bpdc = biphenyl-4,4'-dicarboxylic acid, DMA = N,N'-dimethylacetamide). The incorporation of Cd and carboxylate oxygen affords 1·Cd rich Lewis acid and basic sites. This MOF 1·Cd was then applied as an efficient heterogeneous catalyst for the important cyanosilylation of aldehydes and Knoevenagel condensation reactions...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28210929/effect-of-boswellia-serrata-resin-supplementation-on-basic-chemical-and-mineral-element-composition-in-the-muscles-and-liver-of-broiler-chickens
#9
A R M Al-Yasiry, B Kiczorowska, W Samolińska
Supplementation of broiler chicken diets with resin rich in bioactive components, such as different boswellic acids, could improve productivity, chemical composition, and nutritive value of produced meat. The aim of the study was to assess the effect of different levels of Boswellia serrata (BSR) supplementation in broiler chicken diet on the basic chemical composition and the Ca, P, Mg, Fe, Zn, and Cu contents in the breast and drumstick muscles and liver. The analyses involved 200 Ross 308 chickens. The broiler chickens were fed with diets containing 0 (BSR0), 1...
February 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28210500/drug-release-characteristics-and-tissue-distribution-of-rifapentine-polylactic-acid-sustained-release-microspheres-in-rabbits-after-paravertebral-implantation
#10
Zheng Zhang, Linbo Wu, Haijian Li, Zhicheng Long, Xinghua Song
BACKGROUND: Rates of drug-resistant tuberculosis (TB) and TB associated with human immunodeficiency virus (HIV) infection have increased dramatically, intensifying challenges in TB control. New formulations of TB treatment drugs that control drug release and increase local drug concentrations will have a significant impact on mitigating the toxic side effects and increasing the clinical efficacy of anti-TB drugs. OBJECTIVES: The aim was to observe the sustained release characteristics of rifapentine polylactic acid sustained-release microspheres in vivo and the accumulation of rifapentine in other tissues following paravertebral implantation...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28210240/distinctive-nuclear-localization-signals-in-the-oomycete-phytophthora-sojae
#11
Yufeng Fang, Hyo Sang Jang, Gregory W Watson, Dulani P Wellappili, Brett M Tyler
To date, nuclear localization signals (NLSs) that target proteins to nuclei in oomycetes have not been defined, but have been assumed to be the same as in higher eukaryotes. Here, we use the soybean pathogen Phytophthora sojae as a model to investigate these sequences in oomycetes. By establishing a reliable in vivo NLS assay based on confocal microscopy, we found that many canonical monopartite and bipartite classical NLSs (cNLSs) mediated nuclear import poorly in P. sojae. We found that efficient localization of P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28208305/predicting-electrophoretic-mobility-of-tryptic-peptides-for-high-throughput-cze-ms-analysis
#12
Oleg V Krokhin, Geoffrey Anderson, Vic Spicer, Liangliang Sun, Norman J Dovichi
A multiparametric sequence-specific model for predicting peptide electrophoretic mobility has been developed using large-scale bottom-up proteomic CE-MS data (5% (∼0.8M) acetic acid as background electrolyte). Peptide charge (Z) and size (molecular mass, M) are the two major factors determining electrophoretic mobility, in complete agreement with previous studies. The extended size of the data set (>4000 peptides) permits access to many sequence-specific factors that impact peptide mobility. The presence of acidic residues Asp and Glu near the peptide N-terminus is by far the most prominent among them...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28208270/ceramic-based-multisite-platinum-microelectrode-arrays-morphological-characteristics-and-electrochemical-performance-for-extracellular-oxygen-measurements-in-brain-tissue
#13
Ana Ledo, Cátia F Lourenço, João Laranjinha, Christopher M A Brett, Greg A Gerhardt, Rui M Barbosa
Ceramic-based multisite Pt microelectrode arrays (MEAs) were characterized for their basic electrochemical characteristics and used for in vivo measurements of oxygen with high resolution in the brain extracellular space. The microelectrode array sites showed a very smooth surface mainly composed of thin-film polycrystalline Pt, with some apparent nanoscale roughness that was not translated into an increased electrochemical active surface area. The electrochemical cyclic voltammetric behavior was characteristic of bulk Pt in both acidic and neutral media...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28207232/oxidant-induced-high-efficient-mussel-inspired-modification-on-pvdf-membrane-with-superhydrophilicity-and-underwater-superoleophobicity-characteristics-for-oil-water-separation
#14
Chongdan Luo, Qingxia Liu
In this work, a facile one-step approach was developed to modify hydrophobic polyvinylidene fluoride (PVDF) microfiltration membrane with superhydrophilicity and underwater superoleophobicity properties via a high-efficient deposition of polydopamine (PDA) coating oxidized by sodium periodate in a slightly acidic environment (pH = 5.0). In contrast to the traditional PDA coating on hydrophobic membranes autoxidized by O2 in a weak basic buffer solution, the superhydrophilicity and ultra-high pure water permeability (about 11934 L m-2 h-1 under 0...
February 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28206761/molecular-cobalt-complexes-with-pendant-amines-for-selective-electrocatalytic-reduction-of-carbon-dioxide-to-formic-acid
#15
Souvik Roy, Bhaskar Sharma, Jacques Pecaut, Philippe Simon, Marc Fontecave, Phong D Tran, Etienne Derat, Vincent Artero
We report here on a new series of CO2-reducing molecular catalysts based on Earth-abundant elements that are very selective for the production of acid formic in DMF/water mixtures (Faradaic efficiency of 90±10%) at moderate overpotentials (500-700 mV in DMF measured at the middle of the catalytic wave). The [CpCo(PR2NR'2)I]+compounds contain diphosphine ligands PR2NR'2 with two pendent amine residues that act as proton relays during CO2 reduction catalysis and tune their activity. Four different PR2NR'2 ligands with cyclohexyl or phenyl substituents on phosphorus and benzyl or phenyl substituents on nitrogen were employed and the compound with the most electron-donating phosphine ligand and the most basic amine functions performs best among the series with turnover frequency >1000 s 1...
February 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28204488/correction-to-simultaneous-screening-and-quantification-of-basic-neutral-and-acidic-drugs-in-blood-using-uplc-qtof-ms
#16
Sergei Bidny, Kim Gago, Phuong Chung, Desdemona Albertyn, Daniel Pasin
No abstract text is available yet for this article.
February 16, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28203232/cationic-net-charge-and-counter-ion-type-as-antimicrobial-activity-determinant-factors-of-short-lipopeptides
#17
Katarzyna E Greber, Malgorzata Dawgul, Wojciech Kamysz, Wieslaw Sawicki
To get a better insight into the antimicrobial potency of short cationic lipopeptides, 35 new entities were synthesized using solid phase peptide strategy. All newly obtained lipopeptides were designed to be positively charged from +1 to +4. This was achieved by introducing basic amino acid - lysine - into the lipopeptide structure and had a hydrophobic fatty acid chain attached. Lipopeptides were subjected to microbiological tests using reference strains of Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Pseudomonas aeruginosa, Gram-positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Enterococcus faecalis, and fungi: Candida albicans, Candida tropicalis, Aspergillus brasiliensis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28203100/from-amino-acids-polymers-antimicrobial-peptides-and-histones-to-their-possible-role-in-the-pathogenesis-of-septic-shock-a-historical-perspective
#18
Isaac Ginsburg, Peter Vernon van Heerden, Erez Koren
This paper describes the evolution of our understanding of the biological role played by synthetic and natural antimicrobial cationic peptides and by the highly basic nuclear histones as modulators of infection, postinfectious sequelae, trauma, and coagulation phenomena. The authors discuss the effects of the synthetic polymers of basic poly α amino acids, poly l-lysine, and poly l-arginine on blood coagulation, fibrinolysis, bacterial killing, and blood vessels; the properties of natural and synthetic antimicrobial cationic peptides as potential replacements or adjuncts to antibiotics; polycations as opsonizing agents promoting endocytosis/phagocytosis; polycations and muramidases as activators of autolytic wall enzymes in bacteria, causing bacteriolysis and tissue damage; and polycations and nuclear histones as potential virulence factors and as markers of sepsis, septic shock, disseminated intravasclar coagulopathy, acute lung injury, pancreatitis, trauma, and other additional clinical disorders...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28197594/selenium-makes-the-difference-protonation-of-fefe-hydrogenase-mimics-with-diselenolato-ligands
#19
Hassan Abul-Futouh, Mohammad El-Khateeb, Helmar Görls, Khalil Jamil Asali, Wolfgang Weigand
The synthetic models of the active site of an [FeFe]-hydrogenase containing a Sn atom in the bridgehead of the diselenato ligand, namely [Fe2(CO)6{μ-(SeCH2Se)SnMe2}], 3 and [Fe2(CO)6{μ-(SeCH2)2SnMe2}], 4 have been synthesized and characterized by different spectroscopic methods. The protonation properties of complex 4 have been investigated by monitoring the IR spectra in the carbonyl stretching region, (1)H NMR in the hydride region as well as the (77)Se{H} NMR upon addition of strong and moderate acids wherein the protonation of the active site of the [FeFe]-hydrogenase at one of its internal basic sites is considered an essential step in the catalytic cycle...
February 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28197291/postoperative-right-ventricular-failure-in-cardiac-surgery
#20
REVIEW
Victor H Nieto Estrada, Daniel L Molano Franco, Albert A Valencia Moreno, Jose A Rojas Gambasica, Cristian C Cortes Nunez
Two cases of patients that developed right ventricular failure (RVF) after cardiac valve surgery are presented with a narrative revision of the literature. RVF involves a great challenge due to the severity of this condition; it has a low incidence among non-congenital cardiac surgery patients, is more likely associated with cardiovascular and pulmonary complications related to cardiopulmonary bypass (CPB), and is a cause of acute graft failure and of a higher early mortality in cardiac transplant. The morphologic and hemodynamic characteristics of the right ventricle and some specific factors that breed pulmonary hypertension after cardiac surgery are in favor of the onset of RVF...
December 2016: Cardiology Research
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