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acid basic

Amarateedha H Prak, Kristina M Dela Rosa
With skin lesions that have failed previous treatments, consideration for an atypical mycobacteria, specifically Mycobacterium marinum, infection should be suspected. Importance of the history cannot be stressed as this is a clue that the patient may have been inoculated and infected in the field environment. A marine with chronic right knee plaque for 3 yr that first appeared after a field exercise at The Basic School but worsened despite treatment with clindamycin, TMP-SMX, and incision and drainage in 2012...
March 14, 2018: Military Medicine
Jozef Kováčik, Sławomir Dresler, Petr Babula
Short-term (24 h) responses of Cladonia arbuscula subsp. mitis (formerly known as Cladina and this name is used to distinguish the tested species) and Cladonia furcata to nickel (Ni2+ ) excess (10 or 100 μM) were compared. Cladonia accumulated more Ni at higher Ni dose (1.717 mg total Ni/g DW), K amount was unaffected and Ca amount decreased in Cladina only. Fluorescence microscopy detection of total/general ROS and hydrogen peroxide showed Ni-stimulated increase in both species being more pronounced in Cladonia and in mycobiont partner mainly...
March 6, 2018: Plant Physiology and Biochemistry: PPB
Chao Yang, Yan Qi, Jiayi Zheng, X U Fan, Peixin Liang, Cunjiang Song
Uncontrolled bacterial growth and metabolic activities are responsible for the short shelf life of raw pork. Culture-independent analysis by 16S ribosome cDNA could reveal viable bacteria in raw pork. This study investigated microbial growth and volatile organic compounds of raw pork supplemented with various preservatives. Vacuum-packaged raw pork was stored at 4°C, after soaking in solutions of potassium sorbate, ε-poly-l-lysine, kojic acid (KA), or sodium diacetate, individually. Spoilage of raw pork was monitored by determining pH and total volatile basic nitrogen, whereas bacterial growth was determined by culture-dependent and culture-independent analyses...
March 15, 2018: Journal of Food Protection
Helena Passos, Teresa B V Dinis, Emanuel V Capela, Maria V Quental, Joana Gomes, Judite Resende, Pedro P Madeira, Mara G Freire, João A P Coutinho
In the past decade, the remarkable potential of ionic-liquid-based aqueous biphasic systems (IL-based ABSs) to extract and purify a large range of valued-added biocompounds has been demonstrated. However, the translation of lab-scale experiments to an industrial scale has been precluded by a poor understanding of the molecular-level mechanisms ruling the separation or partition of target compounds between the coexisting phases. To overcome this limitation, we carried out a systematic evaluation of specific interactions, induced by ILs and several salts used as phase-forming components, and their impact on the partition of several solutes in IL-based ABSs...
March 15, 2018: Physical Chemistry Chemical Physics: PCCP
Xian Qi, Xiaofei An, Yongjun Jiao, Huiyan Yu, Ke Xu, Lunbiao Cui, Shenjiao Wang, Fei Deng, Xiang Huo, Haodi Huang, Qigang Dai, Changjun Bao
Five epidemic waves of human infection with influenza A (H7N9) virus have emerged in China since spring 2013. We previously described the epidemiological characterization of the fifth wave in Jiangsu province. In this study, 41 H7N9 viruses from patients and live-poultry markets were isolated and sequenced to further elucidate the genetic features of viruses of the fifth wave in Jiangsu province. Phylogenetic analysis revealed substantial genetic diversity in the internal genes, and 18 genotypes were identified from the 41 H7N9 virus strains...
March 14, 2018: Archives of Virology
Masami Lintuluoto, Juha Mikael Lintuluoto
The inter- and intra-electron and proton transfers in the nitrite reduction of copper-containing nitrite reductase (CuNiR) were investigated by using the QM/MM method with the calculational models containing type 1 (T1) and type 2 (T2) Cu sites. The electron transfer from the outer electron donor protein to the T1 Cu site occurred both before and after nitrite binding, and nitrite binding lowered the reduction potential of the Cu T1 site. The protonation of catalytic His244 subsequent to nitrite binding and T1 Cu reduction induced partial intra-electron transfer from T1 to T2 Cu sites...
March 15, 2018: Metallomics: Integrated Biometal Science
Muhammad Ramzan Manwar Hussain, Zeeshan Iqbal, Wajahat M Qazi, Daniel C Hoessli
The structural and functional diversity of the human proteome is mediated by N - and O- linked glycosylations that define the individual properties of extracellular and membrane-associated proteins. In this study, we utilized different computational tools to perform in silico based genome-wide mapping of 1,117 human proteins and unravel the contribution of both penultimate and vicinal amino acids for the asparagine-based, site-specific N -glycosylation. Our results correlate the non-canonical involvement of charge and polarity environment of classified amino acids (designated as L, O, A, P, and N groups) in the N -glycosylation process, as validated by NetNGlyc predictions, and 130 literature-reported human proteins...
2018: Frontiers in Oncology
Sopheavy Siek, Dalton B Burks, Deidra L Gerlach, Guangchao Liang, Jamie M Tesh, Courtney R Thompson, Fengrui Qu, Jennifer E Shankwitz, Robert M Vasquez, Nicole Chambers, Gregory J Szulczewski, Douglas B Grotjahn, Charles Edwin Webster, Elizabeth T Papish
Hydrogenation reactions can be used to store energy in chemical bonds, and if these reactions are reversible, that energy can be released on demand. Some of the most effective transition metal catalysts for CO2 hydrogenation have featured pyridin-2-ol-based ligands (e.g., 6,6'-dihydroxybipyridine (6,6'-dhbp)) for both their proton-responsive features and for metal-ligand bifunctional catalysis. We aimed to compare bidentate pyridin-2-ol based ligands with a new scaffold featuring an N -heterocyclic carbene (NHC) bound to pyridin-2-ol...
March 27, 2017: Organometallics
Cheol-Jung Lee, Su-Jin Moon, Jeong-Hee Jeong, Sangbae Lee, Mee-Hyun Lee, Sun-Mi Yoo, Hye Suk Lee, Han Chang Kang, Joo Young Lee, Weon Sun Lee, Hee-Jin Lee, Eun-Kyung Kim, Joo-Yeon Jhun, Mi-La Cho, Jun-Ki Min, Yong-Yeon Cho
Rheumatoid arthritis (RA) is a systemic inflammatory disease that mainly affects the synovial joints. Although involvement of the fibroblast growth factor (FGF) signaling pathway has been suggested as an important modulator in RA development, no clear evidence has been provided. In this study, we found that synovial fluid basic FGF (bFGF) concentration was significantly higher in RA than in osteoarthritis (OA) patients. bFGF stimulates proliferation and migration of human fibroblast-like synoviocytes (FLSs) by activation of the bFGF-FGF receptor 3 (FGFR3)-ribosomal S6 kinase 2 (RSK2) signaling axis...
March 14, 2018: Cell Death & Disease
Ishan Ghai, Harsha Bajaj, Jayesh Arun Bafna, Hussein Ali El Damrany Hussein, Mathias Winterhalter, Richard Wagner
The outer cell wall of the Gram-negative bacteria is a crucial barrier for antibiotics to reach their target. Here we show that the chemical stability of the widely used antibiotic ampicillin is a major factor in the permeation across OmpF to reach the target in the periplasm. Using planar lipid bilayer we investigated the interactions and permeation of OmpF with ampicillin, its basic pH induced primary degradation product (penicilloic acid), and the chemically more stable benzylpenicillin. We found that the solute induced ion current fluctuation is 10 times higher with penicilloic-acid than with ampicillin...
March 14, 2018: Journal of Biological Chemistry
M Merced Montero-Campillo, Ibon Alkorta, José Elguero
A set of complexes L2HB···BeX2 (L = CNH, CO, CS, N2, NH3, NCCH3, PH3, PF3, PMe3, OH2; X = H, F) containing a boron-beryllium bond is described at the M06-2X/6-311+G(3df,2pd)//M062-2X/6-31+G(d) level of theory. In this quite unusual bond, boron acts as a Lewis base and beryllium as a Lewis acid, reaching binding energies up to -283.3 kJ/mol ((H2O)2HB···BeF2). The stabilization of these complexes is possible thanks to the -donor role of the L ligands in the L2HB···BeX2 structures and the powerful acceptor nature of beryllium...
March 14, 2018: Journal of Physical Chemistry. A
Katsuaki Kobayashi, Take-Aki Koizumi, Debashis Ghosh, Takashi Kajiwara, Susumu Kitagawa, Koji Tanaka
A RhCp* (Cp* = pentamethylcyclopentadienyl) complex bearing an NAD+ /NADH-functionalized ligand, [RhCp*(pbn)Cl]Cl ([1]Cl, pbn = (2-(2-pyridyl)benzo[b]-1,5-naphthyridine)), was synthesized. The cyclic voltammogram of [1]Cl in CH3 CN shows two reversible redox waves at E1/2 = -0.58 and -1.53 V (vs. the saturated calomel electrode (SCE)), which correspond to the RhIII /RhI and pbn/pbn˙- redox couples, respectively. The addition of acetic acid to the solution afforded the proton-coupled two-electron reduction of [1]Cl at -0...
March 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Anja Kuenz, Susan Krull
Itaconic acid is one of the basic chemicals for the polymer industry, which can be produced on the basis of renewable raw materials. Since the middle of the twentieth century, itaconic acid has been produced industrially using the filamentous fungus Aspergillus terreus. But the demand for the organic acid is low due to the high production costs compared to alternative petrochemical manufactured raw materials. The high production costs are based on a low final titer, low productivities, and the usage of pure sugars, purified molasses, or starch hydrolysates, since the fungus reacts very sensitively to impurities in a culture medium...
March 13, 2018: Applied Microbiology and Biotechnology
Laure Fillaud, Thomas Petenzi, Justine Pallu, Benoit Piro, Giorgio Mattana, Vincent Noel
Stimuli-responsive hydrogels represent a class of materials capable of reversibly switching their morphological and physicochemical characteristics. An ultrathin poly(acrylic acid) film (ca. 6 nm) grafted onto the gate of a p-type EGOFET is studied and the correlation between the swelling state of the hydrogel and the transistor output characteristics is presented. The hydrogel-related swelling process occurring in basic medium causes an increase in threshold voltage due to the abrupt and intense increase of the negative charge density on the gate electrode...
March 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Tatsuru Yamada, Shoji Fujiwara, Kyohhei Fujita, Yuji Tsuchido, Takeshi Hashimoto, Takashi Hayashita
The construction of supramolecular recognition systems based on specific host-guest interactions has been studied in order to design selective chemical sensors. In this study, guest-responsive receptors for ATP have been designed with cyclodextrins (CyDs) as a basic prototype of the turn-on type fluorescent indicator. We synthesized dipicolylamine (DPA)-modified CyD-Cu2+ complexes ( Cu·1 α , Cu·1 β , and Cu·1 γ ), and evaluated their recognition capabilities toward phosphoric acid derivatives in water...
March 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ying Yan, Hui Zhao, Cuihua Chen, Lisi Zou, Xunhong Liu, Chuan Chai, Chengcheng Wang, Jingjing Shi, Shuyu Chen
Eucommia ulmoides Oilv. (EU), also called Du-zhong, is a classical traditional Chinese medicine. Its bark, leaf, and male flower are all used for medicinal purposes, called Eucommiae Cortex (EC), Eucommiae Folium (EF), and Eucommiae Flos Male (EFM). In order to study the difference in synthesis and the accumulation of metabolites in different parts of EU, a reliable method based on ultra-fast liquid chromatography tandem triple quadrupole mass spectrometry (UFLC-QTRAP-MS/MS) was developed for the simultaneous determination of a total of 21 constituents, including two lignans, 6 iridoids, 6 penylpropanoids, 6 flavonoids, and one phenol in the samples (EC, EF, and EFM)...
March 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Christian Manera, Andrezza Piroli Tonello, Daniele Perondi, Marcelo Godinho
In this work, the adsorption of Acid Black 210 (AB210) and Acid Red 357 (AR357) onto activated carbon prepared from leather shaving wastes (ACLW) was investigated. The activated carbon presented a surface area of 800.4 m²/g with an average pore size of 1.27 nm. The kinetic study showed that the adsorption of both dyes followed the Elovich kinetic model while the AB210 and AR357 isotherm data were well described by the Langmuir and BET models, respectively. Furthermore, the Boyd plot revealed that the adsorption of the leather dyes on activated carbon was mainly governed by film diffusion...
March 13, 2018: Environmental Technology
Zhenyi Li, Hongyu Xu, Yue Li, Xiufu Wan, Zhao Ma, Jing Cao, Zhensong Li, Feng He, Yufei Wang, Liqiang Wan, Zongyong Tong, Xianglin Li
The induction of miR399 and miR398 and the inhibition of miR156, miR159, miR160, miR171, miR2111, and miR2643 were observed under Pi deficiency in alfalfa. The miRNA-mediated genes involved in basic metabolic process, root and shoot development, stress response and Pi uptake. Inorganic phosphate (Pi) deficiency is known to be a limiting factor in plant development and growth. However, the underlying miRNAs associated with the Pi deficiency-responsive mechanism in alfalfa are unclear. To elucidate the molecular mechanism at the miRNA level, we constructed four small RNA (sRNA) libraries from the roots and shoots of alfalfa grown under normal or Pi-deficient conditions...
March 12, 2018: Plant Molecular Biology
Jacob D Aguirre, Karen M Dunkerley, Rica Lam, Michele Rusal, Gary S Shaw
Autosomal recessive juvenile Parkinsonism (ARJP) is an inherited neurodegenerative disease in which 50% of affected individuals harbor mutations in the gene encoding the E3 ligase parkin. Parkin regulates the mitochondrial recycling pathway, which is induced by oxidative stress. In its native state, parkin is autoinhibited by its N-terminal ubiquitin-like (Ubl) domain which blocks the binding site for an incoming E2~ubiquitin conjugate, needed for parkin's ubiquitination activity. Parkin is activated via phosphorylation of Ser65 in its Ubl domain by PTEN-induced putative kinase 1 (PINK1) and an ubiquitin molecule phosphorylated at a position equivalent to Ser65 in parkin...
March 12, 2018: Journal of Biological Chemistry
Teresa Ramon-Marquez, Antonio L Medina-Castillo, Naveen Nagiah, Alberto Fernandez-Gutierrez, Jorge F Fernandez-Sanchez
A multifunctional material based on co-electrospinning has been developed as a basic material for the development of biosensors with optical oxygen transduction. It is based on coaxial nanofibres: inner fibres containing an oxygen sensitive dye and outer fibres containing aldehyde groups to allow the formation of Schiff bases with the amino groups of the enzyme. The resulting material preserves the oxygen sensing properties of the inner optical transducer as well as exhibits a high capacity for immobilizing molecules on its surface...
July 26, 2018: Analytica Chimica Acta
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