keyword
MENU ▼
Read by QxMD icon Read
search

acid basic

keyword
https://www.readbyqxmd.com/read/28088022/valorization-of-aluminum-scrap-via-an-acid-washing-treatment-for-reductive-removal-of-toxic-bromate-from-water
#1
Kun-Yi Andrew Lin, Jia-Yin Lin, Hsing-Lung Lien
Aluminum scrap (AS) is adopted for the first time as a readily available aluminum source to prepare zero-valent aluminum (ZVAl) for removing bromate from water via a reductive reaction. Since aluminum is easily oxidized to aluminum oxide (Al2O3) on exposure to air, an acid-washing pretreatment on AS is developed to remove the layer of Al2O3. HCl is found as the most effective acid to pretreat AS and the HCl-pretreated or acid-washed AS (AWAS) is able to remove bromate from water and convert it to bromide. Factors, such as temperature, pH, co-existing anions, and particle size, which influence the bromate removal using AWAS are also investigated...
January 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28087621/the-hook-region-of-voltage-gated-ca2-channel-%C3%AE-subunits-senses-and-transmits-pip2-signals-to-the-gate
#2
Cheon-Gyu Park, Yongsoo Park, Byung-Chang Suh
The β subunit of voltage-gated Ca(2+) (CaV) channels plays an important role in regulating gating of the α1 pore-forming subunit and its regulation by phosphatidylinositol 4,5-bisphosphate (PIP2). Subcellular localization of the CaV β subunit is critical for this effect; N-terminal-dependent membrane targeting of the β subunit slows inactivation and decreases PIP2 sensitivity. Here, we provide evidence that the HOOK region of the β subunit plays an important role in the regulation of CaV biophysics. Based on amino acid composition, we broadly divide the HOOK region into three domains: S (polyserine), A (polyacidic), and B (polybasic)...
January 13, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28087449/highly-biocompatible-chitosan-with-super-paramagnetic-calcium-ferrite-cafe2o4-nanoparticle-for-the-release-of-ampicillin
#3
Ram Bilas, K Sriram, P Uma Maheswari, K M Meera Sheriffa Begum
The CaFe2O4 nanoparticles (CFNP) were synthesized using the solution combustion method. The CFNP-chitosan-ampicillin was prepared by the ionic gelation method using tripolyphosphate (TPP). The CFNP, chitosan-CFNP, chitosan-CFNP-ampicillin materials were characterized by XRD, FT-IR and TGA analysis in order to evaluate the particle nature and size, the presence of functional groups and their thermal stability. The FESEM and EDAX analysis were performed to understand the surface morphology of the materials and the presence of CFNP in the material, respectively...
January 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28087106/charge-variant-analysis-of-proposed-biosimilar-to-trastuzumab
#4
Pravinkumar Dakshinamurthy, Pavithra Mukunda, Bhargav Prasad Kodaganti, Bharath Ravindra Shenoy, Bairavabalakumar Natarajan, Amol Maliwalave, Vivek Halan, Sathyabalan Murugesan, Sunit Maity
Trastuzumab is a humanized monoclonal antibody (mAb) employed for the treatment of HER2 Positive Breast Cancer. A HER2 overexpressing tumor cell binds to Trastuzumab and attracts immune cells which lead to induction of Antibody Dependent Cellular Cytotoxicity (ADCC) by binding to Fc receptors (CD16a or FcγRIIIa) on an effector cell, such as natural killer (NK) cells. The most commonly expressed receptor on NK cell is CD16a which binds to the Fc portion of Trastuzumab. The ligand-independent HER2-HER3 dimerization is the most potent stimulator of downstream pathways for regulation of cell growth and survival...
January 10, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28081501/isolation-characterization-using-lc-esi-qtof-nmr-and-in-vitro-cytotoxicity-assay-of-niclosamide-forced-degradation-products
#5
Johnsirani P, Vishnuvardhan Ch, Lingesh A, Naidu V G M, Naveen Ch, Satheeshkumar N
The present study describes the isolation, characterization and in vitro cytotoxic effect of all forced degradation products of niclosamide (NCM) an anthelmintic class of drug used specifically to treat tapeworms. NCM was subjected to forced degradation involving hydrolysis (acidic, alkaline and neutral), oxidative, photolysis and thermal stress, as per ICH (Q1A (R2)) suggested conditions. The drug under hydrolytic (acidic and basic) conditions showed extensive degradation, while it was stable under neutral hydrolytic, oxidative, photolytic and thermal stress conditions...
January 3, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28080173/evaluation-of-long-term-cryostorage-of-brain-tissue-sections-for-quantitative-histochemistry
#6
Larissa I Estrada, Amy A Robinson, Ana C Amaral, Eustathia L Giannaris, Nadine C Heyworth, Farzad Mortazavi, Laura B Ngwenya, Debra E Roberts, Howard J Cabral, Ronald J Killiany, Douglas L Rosene
Storage of tissue sections for long periods allows multiple samples, acquired over months or years, to be processed together, in the same reagents, for quantitative histochemical studies. Protocols for freezer storage of free-floating frozen sections using sucrose with different additives have been reported and assert that storage has no effect on histochemistry, but no quantitative support has been provided. The present study analyzed the efficacy of long-term storage of brain tissue sections at -80C in buffered 15% glycerol...
January 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28078253/effects-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-on-mitochondrial-dna-replication-and-pgc-1%C3%AE-gene-expression-in-c2c12-muscle-cells
#7
Mak-Soon Lee, Yoonjin Shin, Sohee Moon, Seunghae Kim, Yangha Kim
Mitochondrial biogenesis is a complex process requiring coordinated expression of nuclear and mitochondrial genomes. The peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) is a key regulator of mitochondrial biogenesis, and it controls mitochondrial DNA (mtDNA) replication within diverse tissues, including muscle tissue. The aim of this study was to investigate the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on mtDNA copy number and PGC-1α promoter activity in C2C12 muscle cells...
December 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28075599/enhancing-cation-diffusion-and-suppressing-anion-diffusion-via-lewis-acidic-polymer-electrolytes
#8
Brett M Savoie, Michael A Webb, Thomas F Miller
Solid polymer electrolytes (SPE) have the potential to increase both the energy density and stability of lithium-based batteries, but low Li+ conductivity remains a barrier to technological viability. SPEs are designed to maximize Li+ diffusivity relative to the anion, while maintaining sufficient salt solubility. It is thus remarkable that polyethylene oxide (PEO), the most widely used SPE, exhibits Li+ diffusivity that is an order of magnitude smaller than that of typical counter-ions at moderate salt concentrations...
January 11, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28075409/the-hiv-1-vpr-protein-a-multifaceted-target-for-therapeutic-intervention
#9
REVIEW
María Eugenia González
The human immunodeficiency virus type 1 (HIV-1) Vpr protein is an attractive target for antiretroviral drug development. The conservation both of the structure along virus evolution and the amino acid sequence in viral isolates from patients underlines the importance of Vpr for the establishment and progression of HIV-1 disease. While its contribution to virus replication in dividing and non-dividing cells and to the pathogenesis of HIV-1 in many different cell types, both extracellular and intracellular forms, have been extensively studied, its precise mechanism of action nevertheless remains enigmatic...
January 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28075381/the-n-3-polyunsaturated-fatty-acids-supplementation-improved-the-cognitive-function-in-the-chinese-elderly-with-mild-cognitive-impairment-a-double-blind-randomized-controlled-trial
#10
Yacong Bo, Xueyuan Zhang, Youli Wang, Jie You, Han Cui, Yiwei Zhu, Wei Pang, Wei Liu, Yugang Jiang, Quanjun Lu
OBJECTIVE: Intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) may protect against mild cognitive impairment (MCI). However, there is still a lack of the n-3 PUFAs intervention in the elderly with MCI in China. The aim of the present study was to investigate the effect of n-3 PUFA supplementation on cognitive function in the Chinese elderly with MCI. METHODS: Eighty six MCI individuals aged 60 years or older were randomly assigned to receive either n-3 PUFAs (480 mg DHA and 720 mg EPA per day, n = 44) or placebo (olive oil, n = 42) capsules...
January 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28074741/efficiency-of-rosemary-and-basil-essential-oils-on-the-shelf-life-extension-of-atlantic-mackerel-scomber-scombrus-fillets-stored-at-2%C3%A2-c
#11
Romdhane Karoui, Abdo Hassoun
The objective of the present study was to evaluate the impact of rosemary and basil essential oils (EOs) on the qualityof Atlantic mackerel fillets stored at 2°C up to 15 days. Atlantic mackerel (<em>Scomber scombrus</em>) fillets were periodically evaluated to assess their textural, color, physicochemical, and spectral characteristics. The results indicated that rosemary and basil treatments were effective for inhibiting the formation of total volatile basic nitrogen (TVB-N) and lipid oxidation products during storage...
January 11, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28073414/-protective-effect-of-saccharomyces-boulardii-against-intestinal-mucosal-barrier-injury-in-rats-with-nonalcoholic-fatty-liver-disease
#12
Y T Liu, Y Q Li, Y Z Wang
Objective: To investigate the protective effect of Saccharomyces boulardii against intestinal mucosal barrier injury in rats with nonalcoholic fatty liver disease (NAFLD). Methods: A total of 36 healthy male Sprague-Dawley rats with a mean body weight of 180±20 g were randomly divided into control group, model group, and treatment group, with 12 rats in each group, after adaptive feeding for 1 week. The rats in the control group were given basic feed, and those in the model group and treatment group were given high-fat feed...
December 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28073097/moringa-oleifera-a-species-with-potential-analgesic-and-anti-inflammatory-activities
#13
Claudia Lizbeth Martínez-González, Laura Martínez, Efraín J Martínez-Ortiz, María Eva González-Trujano, Myrna Déciga-Campos, Rosa Ventura-Martínez, Irene Díaz-Reval
Moringa oleifera has long been used in large demand in folk medicine to treat pain. The present study was undertaken to examine the antinociceptive and anti-inflammatory spectrum of M. oleifera leaf extracts discriminating the constituents' nature by using different kind of experimental models in rats. Pharmacological evaluation of a non-polar and/or polar extracts at several doses (30-300mg/kg, p.o.) was explored through experimental nociception using formalin test, carrageenan-induced paw edema and arthritis with subcutaneous injection of collagen in rats...
January 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28069926/creatine-enhances-mitochondrial-mediated-oligodendrocyte-survival-following-demyelinating-injury
#14
Kelly A Chamberlain, Kristen S Chapey, Sonia E Nanescu, Jeffrey K Huang
: Chronic oligodendrocyte loss, which occurs in the demyelinating disorder multiple sclerosis (MS), contributes to axonal dysfunction and neurodegeneration. Current therapies are able to reduce MS severity, but do not prevent transition into the progressive phase of the disease, which is characterized by chronic neurodegeneration. Therefore, pharmacological compounds that promote oligodendrocyte survival could be beneficial for neuroprotection in MS. Here, we investigated the role of creatine, an organic acid involved in ATP buffering, in oligodendrocyte function...
January 9, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28069895/brassinosteroid-induced-transcriptional-repression-and-dephosphorylation-dependent-protein-degradation-negatively-regulate-bin2-interacting-aif2-a-br-signaling-negative-regulator-bhlh-transcription-factor
#15
Yoon Kim, Ji-Hye Song, Seon-U Park, You-Seung Jeong, Soo-Hwan Kim
Brassinosteroids (BRs) are plant polyhydroxy-steroids that play important roles in plant growth and development via extensive signal integration through direct interactions between regulatory components of different signaling pathways. Recent studies have shown that diverse helix-loop-helix/basic helix-loop-helix (HLH/bHLH) family proteins are actively involved in control of BR signaling pathways and interact with other signaling pathways. In this study, we show that ATBS1-INTERACTING FACTOR 2 (AIF2), a nuclear-localized atypical bHLH transcription factor, specifically interacts with BRASSINOSTEROID-INSENSITIVE 2 (BIN2) among other BR-signaling molecules...
January 9, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28069648/the-acinetobacter-outer-membrane-contains-multiple-specific-channels-for-carbapenem-%C3%AE-lactams-as-revealed-by-kinetic-characterization-analyses-of-imipenem-permeation-into-acinetobacter-baylyi-cells
#16
Jorgelina Morán-Barrio, María M Cameranesi, Verónica Relling, Adriana S Limansky, Luciano Brambilla, Alejandro M Viale
The number and type of outer membrane (OM) channels responsible of carbapenem uptake in Acinetobacter are still not well defined. Here, we addressed these questions using Acinetobacter baylyi as a model species and a combination of methodologies aimed to characterize OM channels in their original membrane environment. Kinetic and competition analyses of imipenem (IPM) uptake by A. baylyi whole cells allowed us to identify different carbapenem-specific OM uptake sites. Comparative analyses of IPM uptake by A...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28069316/-hyaluronic-acid-rheology-basics-and-clinical-applications-in-facial-rejuvenation
#17
R Billon, B Hersant, J P Meningaud
Hyaluronic acid (HA) is the most widely used dermal filler to treat facial volume deficits and winkles specially for facial rejuvenation. Depending on various areas of the face, filler is exposed to two different forces (shear deformation and compression/stretching forces) resulting from intrinsec and external mechanical stress. The purpose of this technical note is to explain how rheology, which is the study of the flow and deformation of matter under strains, can be used in our clinical practice of facial volumization with fillers...
January 6, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28069051/traditional-chinese-medicine-combination-therapy-for-patients-with-steroid-dependent-ulcerative-colitis-study-protocol-for-a-randomized-controlled-trial
#18
Kai Zheng, Hong Shen, Jia Jia, Yuelin Lu, Lei Zhu, Lu Zhang, Zhaofeng Shen
BACKGROUND: Approximately 20% of patients with ulcerative colitis become steroid dependent. Azathioprine is recommended in steroid-dependent ulcerative colitis, but its side effects limit its use. Chinese herbal medicine has been widely used to treat ulcerative colitis in China. However, its effectiveness in steroid-dependent patients has not been evaluated. This study aims to investigate the efficacy of traditional Chinese medicine combination therapy with 5-aminosalicylic acid in patients with steroid-dependent ulcerative colitis...
January 10, 2017: Trials
https://www.readbyqxmd.com/read/28068548/selective-dye-adsorption-by-chemically-modified-and-thermally-treated-polymers-of-intrinsic-microporosity
#19
Bekir Satilmis, Peter M Budd
Nitrile groups in the polymer of intrinsic microporosity PIM-1 were modified by base-catalysed hydrolysis, by reaction with ethanolamine and diethanolamine, and by reduction to amine, and the products investigated for their ability to take up a range of dyes from aqueous or ethanolic solution. Hydrolysed products exhibited selectivity for cationic over anionic species, while other products showed the reverse selectivity. At low pH, amine-PIM-1 adsorbed more than its own weight of the anionic dyes Orange II and Acid Red I from aqueous solution...
December 28, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28068400/development-of-a-sensitive-and-specific-polyclonal-antibody-for-serological-detection-of-clavibacter-michiganensis-subsp-sepedonicus
#20
Włodzimierz Przewodowski, Agnieszka Przewodowska
The quarantine bacterium Clavibacter michiganensis subsp. sepedonicus (Cms) causes bacterial ring rot (BRR) in potato but is difficult to detect, hampering the diagnosis of this disease. ELISA immunoassays have not been widely used to detect Cms because commercially available anti-Cms antibodies detect mainly EPS-producing bacteria and can fail to detect strains that do not produce EPS. In the current study, we developed a new type of polyclonal antibody that specifically detects Clavibacter michiganensis subsp...
2017: PloS One
keyword
keyword
67541
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"