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Holistic integrative prevention

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https://www.readbyqxmd.com/read/29110037/a-novel-integrated-in-vitro-carcinogenicity-test-to-identify-genotoxic-and-non-genotoxic-carcinogens-using-human-lymphoblastoid-cells
#1
Eleanor C Wilde, Katherine E Chapman, Leanne M Stannard, Anna L Seager, Katja Brüsehafer, Ume-Kulsoom Shah, James A Tonkin, M Rowan Brown, Jatin R Verma, Ann T Doherty, George E Johnson, Shareen H Doak, Gareth J S Jenkins
Human exposure to carcinogens occurs via a plethora of environmental sources, with 70-90% of cancers caused by extrinsic factors. Aberrant phenotypes induced by such carcinogenic agents may provide universal biomarkers for cancer causation. Both current in vitro genotoxicity tests and the animal-testing paradigm in human cancer risk assessment fail to accurately represent and predict whether a chemical causes human carcinogenesis. The study aimed to establish whether the integrated analysis of multiple cellular endpoints related to the Hallmarks of Cancer could advance in vitro carcinogenicity assessment...
November 6, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29075504/recipients-and-providers-perspectives-of-obesity-and-potential-barriers-to-weight-management-programmes-in-patients-with-rheumatoid-arthritis-ra-a-qualitative-study
#2
G Colligan, J Galloway, H Lempp
BACKGROUND: The UK rheumatology community serves an ageing and ethnically diverse population, with a growing public health concern about obesity. Overweight and obesity contribute to 2.8 million preventable deaths annually. A raised Body Mass Index (BMI) in those with Rheumatoid Arthritis (RA) can have a significant negative impact on clinical outcomes. The aim of the study was to examine patients' and providers' perceptions of obesity and potential barriers to participation in a future weight management programme to contribute to an appropriate intervention design...
2017: BMC Obesity
https://www.readbyqxmd.com/read/29058214/physiological-informatics-collection-and-analyses-of-data-from-wearable-sensors-and-smartphone-for-healthcare
#3
Jinwei Bai, Li Shen, Huimin Sun, Bairong Shen
Physiological data from wearable sensors and smartphone are accumulating rapidly, and this provides us the chance to collect dynamic and personalized information as phenotype to be integrated to genotype for the holistic understanding of complex diseases. This integration can be applied to early prediction and prevention of disease, therefore promoting the shifting of disease care tradition to the healthcare paradigm. In this chapter, we summarize the physiological signals which can be detected by wearable sensors, the sharing of the physiological big data, and the mining methods for the discovery of disease-associated patterns for personalized diagnosis and treatment...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28973378/understanding-how-indigenous-culturally-based-interventions-can-improve-participants-health-in-canada
#4
Jayne Murdoch-Flowers, Marie-Claude Tremblay, Richard Hovey, Treena Delormier, Katherine Gray-Donald, Elaine Delaronde, Ann C Macaulay
There is increasing recognition that culturally-based diabetes prevention programs can facilitate the adoption and maintenance of healthy behaviours in the communities in which they are implemented. The Kahnawake School Diabetes Prevention Project (KSDPP) is a health promotion, community-based participatory research project aiming to reduce the incidence of Type 2 diabetes in the community of Kahnawake (Mohawk territory, Canada), with a large range of interventions integrating a Haudenosaunee perspective of health...
September 14, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28919380/establishing-a-hospital-based-fracture-liaison-service-to-prevent-secondary-insufficiency-fractures
#5
REVIEW
Shahryar Noordin, Salim Allana, Bassam A Masri
Insufficiency fracture care requires more than surgery to ensure rapid and strong union with diminished chance of future fractures. The FLS program provides an opportunity to treat osteoporosis from a public health perspective rather than leaving this to the whims of individual physicians. This is achieved by providing a seamless integration of care by health care providers, nursing staff and administration. The FLS can be adapted to any model of care including academic health systems. FLS provides a holistic approach to identify patients as well as to provide evidence-based interventions to prevent subsequent fractures...
September 12, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28870618/revisiting-the-theoretical-basis-of-the-endosymbiotic-origin-of-plastids-in-the-original-context-of-lynn-margulis-on-the-origin-of-mitosing-eukaryotic-cells
#6
Naoki Sato
Fifty years ago, Lynn Margulis proposed a comprehensive hypothesis on the origin of eukaryotic cells with an emphasis on the origin of mitosis. This hypothesis postulated that the eukaryotic cell is a composite of different parts as a result of the symbiosis of various different bacteria. In this hypothesis, she integrated previously proposed ideas that mitochondria and chloroplasts were descendants of endosymbionts that originated from aerobic bacteria and blue-green algae (now cyanobacteria), respectively...
September 7, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28866951/best-practices-new-perspectives-and-the-perfect-emollient-optimizing-the-management-of-contact-dermatitis
#7
Jean-Marie Lachapelle, Ana Gimenez-Arnau, Martin Metz, Jill Peters, Ehrhardt Proksch
Contact dermatitis (CD) is caused by environmental agents, irritants and allergens, that penetrate the epidermis and lead to inflammation. An intact skin barrier prevents penetration and is important in maintaining healthy skin. Classical diagnosis of CD is made using the patch test, and traditional treatment strategies for CD promote skin barrier integrity and resolve the inflammatory component of the condition. This can be achieved by using emollient-based therapy, which is most important for skin barrier repair, and in addition to topical glucocorticosteroids, which are used in severe cases of CD and are most effective in reducing inflammation...
September 4, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28859556/the-perceptions-of-first-nation-participants-in-a-community-oral-health-initiative
#8
Kavita R Mathu-Muju, James McLeod, Leeann Donnelly, Rosamund Harrison, Michael I MacEntee
The Children's Oral Health Initiative (COHI) is a federally funded community-based preventive dental program for children and their caregivers living in geographically isolated Canadian Aboriginal communities. The goal of the program is to improve access to preventive dental services for children of 0-7 years of age. It utilises community health workers in collaboration with dental therapists to promote and deliver the program. Almost half of the province of Manitoba's (n=27) First Nations communities have implemented COHI since 2005...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28859266/optimization-of-human-animal-and-environmental-health-by-using-the-one-health-approach
#9
REVIEW
Jonathan M Sleeman, Thomas DeLiberto, Natalie Nguyen
Emerging diseases are increasing burdens on public health, negatively affecting the world economy, causing extinction of species, and disrupting ecological integrity. One Health recognizes that human, domestic animal, and wildlife health are interconnected within ecosystem health and provides a framework for the development of multidisciplinary solutions to global health challenges. To date, most health-promoting interventions have focused largely on single-sector outcomes. For example, risk for transmission of zoonotic pathogens from bush-meat hunting is primarily focused on human hygiene and personal protection...
August 31, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28841481/a-novel-array-of-interface-confined-molecules-assembling-natural-segments-for-delivery-of-multi-functionalities
#10
Sampson Anankanbil, Bianca Pérez, Jingwen Yang, Chiranjib Banerjee, Zheng Guo
HYPOTHESIS: Anionic surfactants can form stable monolayers around oil droplets via interactions with macromolecules thereby physically stabilizing high fish oil enriched emulsions (50-70% fish oil) while phenolic acids have antioxidant properties to prevent lipid oxidation. COSMO-RS (Conductor-like Screening Model for Real Solvents) is a powerful tool for the rational design of molecules with multi-functionalities. Therefore, it should be possible to assemble segments of natural molecules into a single multifunctional molecule using COSMO-RS to confer both physical and oxidative stability to fish oil enriched systems...
August 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28835028/-holistic-integrative-medicine-application-in-prevention-and-treatment-of-oral-mucosal-diseases
#11
X Jin, L Xie, X Zhao, J Li, X Zeng, Q M Chen
Holistic integrative medicine (HIM), as one of the important ideas in the field of medicine, arouses great concern recently. HIM regards the human body as a whole, turns data and evidence in medical research back to facts, integrates technologies and experience developed in clinical research into medical skills. The repeated practices at the levels of fact, experience, and medical skills will generate true knowledge to solve the wide spread problems brought by linearized thinking and fragmented knowledge. With the development of highly divided medical disciplines, how to utilize and practice HIM has become a common concern of the medical community...
August 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28835027/-periodontology-from-the-perspective-of-holistic-integrative-medicine
#12
Q X Luan
Medical diciplines have been gradually differentiated and specialized during its developement, and problems due to deep specialization have been increasingly apparent. Its performance is as follows: dental specialists tends to focus on a certain narrow area and ignore neither the patients as a whole existence nor the role of the environmental factors. In this article, the author tries to show the holistic integrative medicine (HIM) from the point of view of periodontal specialty. In fact, the pathogenesis, the differential diagnosis and the treatment of periodontal diseases along with the role of preventive dentistry and basic medicine for periodontology must be considered as a whole using the philosophy of HIM...
August 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28803713/a-review-of-the-key-factors-to-improve-adult-immunization-coverage-rates-what-can-the-clinician-do
#13
Litjen L J Tan
Adult immunization coverage rates remain low in the United States and internationally, despite obvious benefits to vaccinating and maintaining a well-vaccinated adult population. Broad policy changes are required to identify and address gaps in financing, in immunization infrastructure, and patient and provider awareness and knowledge to improve the protection of our adult and aging population from vaccine-preventable diseases. There is good evidence that efforts are now underway both within the United States and across the world to advance these policy changes...
August 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28723407/nano-lipid-drug-conjugate-an-integrated-review
#14
REVIEW
Piya Adhikari, Paulami Pal, Anup Kr Das, Subhabrata Ray, Arpita Bhattacharjee, Bhaskar Mazumder
Lipid-drug conjugates (LDC), which may also be addressed as lipoidal prodrug, have the therapeutic actives chemically bound to a lipid moiety like fatty acids or phospholipids. Fabricated in nano-size, lipid-drug conjugate forms another breed of lipid nanoparticles. LDCs are prepared in order to increase the drug loading and hence prevent leakage of a highly polar drug from a lipophilic matrix. In turn, it assists to achieve active targeting of therapeutics with reduced side effect by altering the pharmacokinetic profile of the drug...
July 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28597858/policy-and-governance-to-address-depression-and-suicide-in-bhutan-the-national-suicide-prevention-strategy
#15
Gampo Dorji, Sonam Choki, Kinga Jamphel, Yeshi Wangdi, Tandin Chogyel, Chencho Dorji, Damber Kumar Nirola
Suicide and mental disorders are a growing public health issue in Bhutan, due in part to a rapidly transitioning society. The burden of suicide has been recognized by the Royal Government of Bhutan and, as a result, it introduced the country's first ever national suicide-prevention plan in 2015. The 3-year action plan takes a holistic approach to making suicide-prevention services a top social priority, through strengthening suicide-prevention policies, promoting socially protective measures, mitigating risk factors and reaching out to individuals who are at risk of suicide or affected by incidents of suicide...
April 2017: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28521830/evidence-based-policy-responses-to-strengthen-health-community-and-legislative-systems-that-care-for-women-in-australia-with-female-genital-mutilation-cutting
#16
REVIEW
Nesrin Varol, John J Hall, Kirsten Black, Sabera Turkmani, Angela Dawson
BACKGROUND: The physical and psychological impact of female genital mutilation / cutting (FGM/C) can be substantial, long term, and irreversible. Parts of the health sector in Australia have developed guidelines in the management of FGM/C, but large gaps exist in community and professional knowledge of the consequences and treatment of FGM/C. The prevalence of FGM/C amongst Australian women is unknown. Our article reviews the literature on research on FGM/C in Australia, which focuses on health system response to women and girls with FGM/C...
May 18, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28483271/-mindful-neuropsychology-mindfulness-based-cognitive-remediation
#17
E Bulzacka, S Lavault, A Pelissolo, C Bagnis Isnard
OBJECTIVES: Mindfulness based interventions (MBI) have recently gained much interest in western medicine. MBSR paradigm is based on teaching participants to pay complete attention to the present experience and act nonjudgmentally towards stressful events. During this mental practice the meditator focuses his or her attention on the sensations of the body. While the distractions (mental images, thoughts, emotional or somatic states) arise the participant is taught to acknowledge discursive thoughts and cultivate the state of awareness without immediate reaction...
May 5, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28436758/amphetamine-type-stimulants-ats-use-and-homosexuality-related-enacted-stigma-are-associated-with-depression-among-men-who-have-sex-with-men-msm-in-two-major-cities-in-vietnam-in-2014
#18
Nga Thi Thu Vu, Martin Holt, Huong Thi Thu Phan, Lan Thi La, Gioi Minh Tran, Tung Thanh Doan, Trang Nguyen Nhu Nguyen, John de Wit
BACKGROUND: Men who have sex with men (MSM) are disproportionately affected by mental health concerns, including depression. Amphetamine-type-stimulants (ATS) use and homosexuality-related stigma and discrimination have been found associated with depression among MSM. OBJECTIVES: To assess the prevalence of depression and its associations with ATS use and homosexuality-related stigma and discrimination among MSM in Vietnam. METHODS: 622 MSM were conveniently recruited in Hanoi and Ho Chi Minh city, Vietnam, from September to December 2014...
April 24, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28427131/-recognizing-prevention-and-treatment-of-burn-sepsis-with-the-concept-of-holistic-integrative-medicine
#19
J N Huan
Sepsis remains a major cause of death in severe burns. The effect of sepsis management is influenced by its complicated pathophysiologic changes. In order to improve the outcome of burn sepsis, the predisposing factor of sepsis after burn analyzed by advanced technology, the early prevention, antibiotics therapy, and combined treatment in severe burns with sepsis are discussed using the concept of holistic integrative medicine.
April 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28344933/precision-medicine-the-golden-gate-for-detection-treatment-and-prevention-of-alzheimer-s-disease
#20
H Hampel, S E O'Bryant, J I Castrillo, C Ritchie, K Rojkova, K Broich, N Benda, R Nisticò, R A Frank, B Dubois, V Escott-Price, S Lista
During this decade, breakthrough conceptual shifts have commenced to emerge in the field of Alzheimer's disease (AD) recognizing risk factors and the non-linear dynamic continuum of complex pathophysiologies amongst a wide dimensional spectrum of multi-factorial brain proteinopathies/neurodegenerative diseases. As is the case in most fields of medicine, substantial advancements in detecting, treating and preventing AD will likely evolve from the generation and implementation of a systematic precision medicine strategy...
December 2016: Journal of Prevention of Alzheimer's Disease
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