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Holistic integrative prevention

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https://www.readbyqxmd.com/read/29735851/cancer-prevention-the-need-to-preserve-the-integrity-of-the-genome-at-all-cost
#1
REVIEW
M T Okafor, T U Nwagha, C Anusiem, U A Okoli, N I Nubila, F Al-Alloosh, I J Udenyia
Introduction: The entire genetic information carried by an organism makes up its genome. Genes have a diverse number of functions. They code different proteins for normal proliferation of cells. However, changes in the base sequence of genes affect their protein by-products which act as messengers for normal cellular functions such as proliferation and repairs. Salient processes for maintaining the integrity of the genome are hinged on intricate mechanisms put in place for the evolution to tackle genomic stresses...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29716650/humans-as-holobionts-implications-for-prevention-and-therapy
#2
REVIEW
Maarten van de Guchte, Hervé M Blottière, Joël Doré
The human gut microbiota is increasingly recognized for its important or even decisive role in health. As it becomes clear that microbiota and host mutually affect and depend on each other in an intimate relationship, a holistic view of the gut microbiota-host association imposes itself. Ideally, a stable state of equilibrium, homeostasis, is maintained and serves health, but signs are that perturbation of this equilibrium beyond the limits of resilience can propel the system into an alternative stable state, a pre-disease state, more susceptible to the development of chronic diseases...
May 1, 2018: Microbiome
https://www.readbyqxmd.com/read/29673253/depression-poverty-and-abuse-experience-in-suicide-ideation-among-older-koreans
#3
Shin-Young Lee, Madhu Sudhan Atteraya
We examined to what extent the depression, poverty, and elder abuse experience affect suicide ideation among older Koreans. The data from the Survey of Living Conditions and Welfare Needs of Korean Older Persons were used. A sample of 10,279 members was analyzed. Logistic regression analysis revealed that younger old (65-69 years) were more likely to have suicide ideation that oldest old (80 years and older). After including all predicting variables such as depression, poverty, and abuse experience, results showed that depression, poverty, and abuse experience remained predictors for suicide ideation...
January 1, 2018: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29587401/inactivation-of-srebp-1a-phosphorylation-prevents-fatty-liver-disease-in-mice-identification-of-related-signaling-pathways-by-gene-expression-profiles-in-liver-and-proteomes-of-peroxisomes
#4
Birgit Knebel, Sonja Hartwig, Sylvia Jacob, Ulrike Kettel, Martina Schiller, Waltraud Passlack, Cornelia Koellmer, Stefan Lehr, Dirk Müller-Wieland, Jorg Kotzka
The key lipid metabolism transcription factor sterol regulatory element-binding protein (SREBP)-1a integrates gene regulatory effects of hormones, cytokines, nutrition and metabolites as lipids, glucose, or cholesterol via phosphorylation by different mitogen activated protein kinase (MAPK) cascades. We have previously reported the impact of SREBP-1a phosphorylation on the phenotype in transgenic mouse models with liver-specific overexpression of the N-terminal transcriptional active domain of SREBP-1a (alb-SREBP-1a) or a MAPK phosphorylation site-deficient variant (alb-SREBP-1a∆P; (S63A, S117A, T426V)), respectively...
March 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29572106/temporary-removal-an-integrated-evidence-based-targeting-strategy-for-determining-combinatorial-bioactive-ingredients-of-a-compound-herbal-medicine-qishen-yiqi-dripping-pills
#5
Yiqian Zhang, Jiahui Yu, Wen Zhang, Yuewei Wang, Yi He, Shuiping Zhou, Guanwei Fan, Yang Hua, Yan Zhu, Ping Li
No abstract text is available yet for this article.
March 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29566687/-it-was-the-whole-picture-a-mixed-methods-study-of-successful-components-in-an-integrated-wellness-service-in-north-east-england
#6
M Cheetham, P Van der Graaf, B Khazaeli, E Gibson, A Wiseman, R Rushmer
BACKGROUND: A growing number of Local Authorities (LAs) have introduced integrated wellness services as part of efforts to deliver cost effective, preventive services that address the social determinants of health. This study examined which elements of an integrated wellness service in the north east of England were effective in improving health and wellbeing (HWB). METHODS: The study used a mixed-methods approach. In-depth semi-structured interviews (IVs) were conducted with integrated wellness service users (n = 25) and focus groups (FGs) with group based service users (n = 14) and non-service users (n = 23) to gather the views of stakeholders...
March 22, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29557202/targeting-the-psychosocial-and-functional-fitness-challenges-of-older-adults-with-hearing-loss-a-participatory-approach-to-adaptation-of-the-walk-and-talk-for-your-life-program
#7
Marc Jutras, Justin Lambert, Jiyoung Hwang, Lisa Wang, Shane Simon, Talia Del Medico, Paul Mick, Harry Miller, Donna Kurtz, Mary-Ann Murphy, Charlotte Ann Jones
OBJECTIVE: Explore the acceptability of a socialisation, health education and falls prevention programme (Walk and Talk for Your Life: WTL) as an adjunct to group auditory rehabilitation (GAR) and how it might be adapted for older adults with hearing loss (HL). DESIGN: Content theme analysis (CTA) of guided interviews explored the experience of HL, the acceptability of a WTL programme and suggestions on how to adapt the WTL programme to better suit the needs of older adults with HL...
March 20, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29545169/integrating-multi-source-information-on-a-single-network-to-detect-disease-related-clusters-of-molecular-mechanisms
#8
Margarita Zachariou, George Minadakis, Anastasis Oulas, Sotiroula Afxenti, George M Spyrou
The abundance of available information for each disease from multiple sources (e.g. as genetic, regulatory, metabolic, and protein-protein interaction) constitutes both an advantage and a challenge in identifying disease-specific underlying mechanisms. Integration of multi-source data is a rising topic and a great challenge in precision medicine and is crucial in enhancing disease understanding, identifying meaningful clusters of molecular mechanisms and increasing precision and personalisation towards the goal of Predictive, Preventive and Personalised Medicine (PPPM)...
March 13, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29508478/being-we-and-being-me-exploring-the-needs-of-austrian-families-with-caring-children
#9
Martin Nagl-Cupal, Julia Hauprich
Children and adolescents with caring responsibilities are an uncontested reality in our society. Most are hidden from public view, and they perform a broad range of caring activities for chronically ill or disabled family members. The research literature has accumulated a comprehensive body of knowledge about young carers' personal needs. However, knowledge and understanding are limited regarding the needs of young carers' families. This knowledge can contribute to preventing children and adolescents from assuming inappropriate caring roles...
March 5, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29505459/bariatric-outcomes-self-management-for-sustained-surgical-success-a-multicomponent-treatment-for-dysregulated-overeating-in-bariatric-surgery-patients
#10
Laura M Anderson, Thomas P Chacko
Binge eating disorder, food addiction, and dysregulated overeating are common among people with severe obesity and prevalent among bariatric surgery populations. These problematic eating habits share commonalities with other addictions. Effective, holistic self-management is needed to promote long-term weight loss and psychosocial adjustment among patients who are severely obese who undergo surgery, especially those with clinically remarkable levels of binge eating, food addiction, or dysregulated overeating...
January 2018: Journal of Addictions Nursing
https://www.readbyqxmd.com/read/29488895/-the-concept-of-urban-resilience-and-its-relation-to-resilience-in-mental-health-prospects-for-research-in-schizophrenia
#11
N G Christodoulou, M L Wassenhoven, S T Rassia
The relationship between schizophrenia and the city is well known and widely documented in the literature, albeit with many questions still unanswered. While it is clear that there is a higher incidence of schizophrenia in cities, there is little known on causality - or its direction - in that relationship. Also, despite the fact that several clinical and epidemiological parameters play a role in the relationship between schizophrenia and the city, this relationship has not been investigated or interpreted holistically...
October 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29485797/healthy-settings-in-hospital-how-to-prevent-burnout-syndrome-in-nurses-literature-review
#12
REVIEW
Adriano Friganović, Irena Kovačević, Boris Ilić, Mirna Žulec, Valentina Krikšić, Cecilija Grgas Bile
Healthy settings involve a holistic and multidisciplinary method that integrates actions towards risk factors. In hospital settings, a high level of stress can lead to depression, anxiety, decreased job satisfaction and lower loyalty to the organization. Burnout syndrome can be defined as physical, psychological and emotional exhaustion, depersonalization, and low sense of personal accomplishment. The aim of this literature review was to make systematic literature analysis to provide scientific evidence for the consequences of constant exposure to high levels of stress and for the methods to be used to prevent burnout syndrome among health care workers...
June 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29482259/-the-contributions-of-the-east-german-sports-medicine-specialist-and-neurologist-bernhard-schwarz-1918-1991-in-the-field-of-boxing
#13
Katrin Bart, Holger Steinberg
This study is the first to provide research on the East-German (GDR) sports physician and neurologist Bernhard Schwarz. It summarises Schwarz's publications from 1953 to 1966 regarding the impact of boxing on health, particularly craniocerebral injury. Also, the study analyses his work in the context of current discussions. It shows that Schwarz, who was a tenured professor and director of the Department of Psychiatry at the University Hospital of Leipzig and the physician of the GDR national boxing team, conducted systematic clinical surveys and pointed to the health impacts of boxing at an early point in time...
March 2018: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29454383/multidimensional-needs-of-patients-living-and-dying-with-heart-failure-in-kenya-a-serial-interview-study
#14
Kellen N Kimani, Scott A Murray, Liz Grant
BACKGROUND: Heart failure is an emerging challenge for Sub Saharan Africa. However, research on patients' needs and experiences of care is scarce with little evidence available to support and develop services. We aimed to explore the experiences of patients living and dying with heart failure in Kenya. METHODS: We purposively recruited 18 patients admitted with advanced heart failure at a rural district hospital in Kenya. We conducted serial in depth interviews with patients at 0, 3 and 6 months after recruitment, and conducted bereavement interviews with carers...
February 17, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29362952/the-role-of-the-clinician-in-the-multi-omics-era-are-you-ready
#15
Clara D M van Karnebeek, Saskia B Wortmann, Maja Tarailo-Graovac, Mirjam Langeveld, Carlos R Ferreira, Jiddeke M van de Kamp, Carla E Hollak, Wyeth W Wasserman, Hans R Waterham, Ron A Wevers, Tobias B Haack, Ronald J A Wanders, Kym M Boycott
Since Garrod's first description of alkaptonuria in 1902, and newborn screening for phenylketonuria introduced in the 1960s, P4 medicine (preventive, predictive, personalized, and participatory) has been a reality for the clinician serving patients with inherited metabolic diseases. The era of high-throughput technologies promises to accelerate its scale dramatically. Genomics, transcriptomics, epigenomics, proteomics, glycomics, metabolomics, and lipidomics offer an amazing opportunity for holistic investigation and contextual pathophysiologic understanding of inherited metabolic diseases for precise diagnosis and tailored treatment...
January 23, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29358424/study-protocol-for-one-health-data-collections-analyses-and-intervention-of-the-sino-swedish-integrated-multisectoral-partnership-for-antibiotic-resistance-containment-impact
#16
Qiang Sun, Yang Wang, Anette Hulth, Yonghong Xiao, Lennart E Nilsson, Xuewen Li, Zhenwang Bi, Yuqing Liu, Hong Yin, Yanbo Luo, Maud Nilsson, Chengtao Sun, Yiqing Zhu, Beiwen Zheng, Baoli Chen, Pan Sun, Lilu Ding, Xi Xia, Jakob Ottoson, Sonja Löfmark, Oliver James Dyar, Stefan Börjesson, Cecilia Stalsby Lundborg
INTRODUCTION: To effectively minimise the emergence and dissemination of antibiotic resistant bacteria, a holistic One Health approach is called for. The Sino-Swedish Integrated Multisectoral Partnership for Antibiotic Resistance Containment is a cross-sectoral and integrated project on antibiotic resistance, conducted in Shandong Province in China. This paper outlines the overall study protocol for the project. To our knowledge, this is the first research programme aiming to take a true holistic approach across multiple sectors simultaneously in China, and the first to incorporate both antibiotic use and infection prevention and control in addition to antibiotic resistance patterns...
January 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29357674/associating-symptom-phenotype-and-genotype-in-preeclampsia
#17
Sandra A Founds, Eleni Tsigas, Dianxu Ren, M Michael Barmada
Preeclampsia is a complex genetic disorder with an incompletely understood pathogenesis. Its phenotype may be better elucidated by integrating symptoms. This study aimed to identify symptoms by gestational age and associations with novel preeclampsia candidate genes. Women with a history of preeclampsia recruited from The Preeclampsia Registry completed clinical/demographic, symptom surveys and provided medical records. DNA extracted from saliva was processed with multiplexed assays for eight single-nucleotide polymorphisms (SNPs) selected to tag candidate genes and/or located in symptom susceptibility regions...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29317079/biotensegrity-and-myofascial-chains-a-global-approach-to-an-integrated-kinetic-chain
#18
S L Dischiavi, A A Wright, E J Hegedus, C M Bleakley
Human movement is a complex orchestration of events involving many different body systems. Understanding how these systems interact during musculoskeletal movements can directly inform a variety of research fields including: injury etiology, injury prevention and therapeutic exercise prescription. Traditionally scientists have examined human movement through a reductionist lens whereby movements are broken down and observed in isolation. The process of reductionism fails to capture the interconnected complexities and the dynamic interactions found within complex systems such as human movement...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29196862/voluntary-exposure-to-a-toxin-the-genetic-influence-on-ethanol-consumption
#19
Paula L Hoffman, Laura M Saba, Lauren A Vanderlinden, Boris Tabakoff
Ethyl alcohol is a toxin that, when consumed at high levels, produces organ damage and death. One way to prevent or ameliorate this damage in humans is to reduce the exposure of organs to alcohol by reducing alcohol ingestion. Both the propensity to consume large volumes of alcohol and the susceptibility of human organs to alcohol-induced damage exhibit a strong genetic influence. We have developed an integrative genetic/genomic approach to identify transcriptional networks that predispose complex traits, including propensity for alcohol consumption and propensity for alcohol-induced organ damage...
February 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29172161/urban-upbringing-and-childhood-respiratory-and-allergic-conditions-a-multi-country-holistic-study
#20
Christina Tischer, Payam Dadvand, Xavier Basagana, Elaine Fuertes, Anna Bergström, Olena Gruzieva, Erik Melen, Dietrich Berdel, Joachim Heinrich, Sibylle Koletzko, Iana Markevych, Marie Standl, Dorothea Sugiri, Lourdes Cirugeda, Marisa Estarlich, Ana Fernández-Somoano, Amparo Ferrero, Jesus Ibarlueza, Aitana Lertxundi, Adonina Tardón, Jordi Sunyer, Josep M Anto
OBJECTIVE: We integratively assessed the effect of different indoor and outdoor environmental exposures early in life on respiratory and allergic health conditions among children from (sub-) urban areas. METHODS: This study included children participating in four ongoing European birth cohorts located in three different geographical regions: INMA (Spain), LISAplus (Germany), GINIplus (Germany) and BAMSE (Sweden). Wheezing, bronchitis, asthma and allergic rhinitis throughout childhood were assessed using parental-completed questionnaires...
February 2018: Environmental Research
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