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The elephant in the room

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https://www.readbyqxmd.com/read/28929908/dissociative-and-complex-trauma-disorders-in-health-and-mental-health-contexts-or-why-is-the-elephant-not-in-the-room
#1
Kevin J Connors
No abstract text is available yet for this article.
September 20, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28864753/bipolar-disorder-and-addictions-the-elephant-in-the-room
#2
EDITORIAL
Paul R A Stokes, Nicola J Kalk, Allan H Young
Addictions are highly prevalent in bipolar disorder and greatly affect clinical outcomes. In this editorial, we review the evidence that addictions are a key challenge in bipolar disorder, examine putative neurobiological mechanisms, and reflect on the limited clinical trial evidence base with suggestions for treatment strategies and further developments.
September 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28813169/the-elephant-in-the-room
#3
Joan E Dodgson
No abstract text is available yet for this article.
August 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28812848/the-elephants-in-the-room-sex-hiv-and-lgbt-populations-in-mena-intersectionality-in-lebanon-comment-on-improving-the-quality-and-quantity-of-hiv-data-in-the-middle-east-and-north-africa-key-challenges-and-ways-forward
#4
Rachel L Kaplan, Cynthia El Khoury
In response to this insightful editorial, we wish to provide commentary that seeks to highlight recent successes and illuminate the often unspoken hurdles at the intersections of culture, politics, and taboo. We focus on sexual transmission and draw examples from Lebanon, where the pursuit of data in quality and quantity is teaching us lessons about the way forward and where we are experiencing many of the challenges referenced in the editorial such as discrepancies between national statistics and rates derived via research as well as the impact of protracted political conflict and displacement...
December 4, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28797283/incident-gout-and-erectile-dysfunction-is-hyperuricaemia-the-elephant-in-the-room
#5
EDITORIAL
Abhishek Abhishek, Michael Doherty
The first prospective population-based study to examine risk of erectile dysfunction in men with gout in the western world has been published. It reports that following their first diagnosis of gout, men have a 31% higher risk of erectile dysfunction than matched controls, although the absolute increase in risk is small. Of interest, the incidence of erectile dysfunction reported in this study is tenfold higher than those reported in nation-wide cohort studies from Taiwan. There is a need for further prospective cohort studies to examine the possible mechanistic association between gout, hyperuricaemia and erectile dysfunction...
August 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28765235/letter-to-the-editor-auc-for-v-q-imaging-in-pulmonary-embolism-the-elephant-in-the-room-planar-or-spect-v-q
#6
Pierre-Yves Le Roux, Pierre-Yves Salaun
No abstract text is available yet for this article.
August 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28747016/unveiling-the-elephant-in-the-room-the-dilemma-of-patients-managed-medically-after-non-st-segment-elevation-acute-coronary-syndromes
#7
EDITORIAL
David Eccleston
No abstract text is available yet for this article.
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28739107/hydrostatic-pressure-and-the-experimental-toxicology-of-marine-fishes-the-elephant-in-the-room
#8
Benjamin Lemaire
Hydrostatic pressure (HP) increases linearly with depth in aquatic environments, so that many fish species routinely experience moderate-to-high HP levels (i.e., from a few to dozens of MPa). Biological effects of this thermodynamic variable are evidenced by a reduced functionality of many biomolecular systems, even in barotolerant and barophilic species. It is likely that environmentally-relevant HP levels (i.e., above atmospheric) could also modulate the responsiveness to and toxic effects of pollutants in fish...
July 21, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28722449/how-large-is-the-elephant-in-the-density-functional-theory-room
#9
Frank Jensen
A recent paper reported highly accurate density functional theory results for atomization energies and dipole moments using a multiwavelet-based method and compared the results with those obtained by standard Gaussian basis sets of the aug-cc-pVXZ type. Typical errors with the large aug-cc-pV5Z basis set were in the 0.2 kcal/mol range with outliers displaying errors of ∼2 kcal/mol, and these results could be taken as an indication that Gaussian basis sets in general are unsuitable for achieving high accuracy...
August 3, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28721021/addressing-the-elephant-in-the-room-a-possible-new-way-to-increase-patient-adherence-to-medical-advice
#10
Gudmund Grønhaug
Lack of patient adherence to medical advice (PAMA) is recognized as an area of interest. None of the previous initiatives to improve PAMA, such as patient centered care and shared decision making, have proved to be successful in terms of improving patient adherence. The aim of the present study is to assess beliefs about priorities in public health care, and adherence to medical advice, to establish a novel approach to increase PAMA. The present study is based on responses to two questions in an experimental survey from the Norwegian Citizen Panel, addressing people's attitudes to priorities in public health care and adherence to medical advice...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28656582/an-historical-perspective-of-the-discovery-of-titin-filaments
#11
REVIEW
Cris Dos Remedios, Darcy Gilmour
This review takes readers back to 1949, when two Australian scientists, Draper and Hodge, reported the first high-resolution electron microscopy images of striated muscle. In 1953, Jean Hanson and Hugh Huxley published phase-contrast microscopy and electron microscopy images that established the filamentous nature of the sarcomere, namely the myosin-containing thick filaments and actin-containing thin filaments. They discussed a putative third filament system, possibly a thinner actin-containing S filament, that appeared to connect one Z disc to the next...
June 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28600784/the-elephant-in-the-room-the-role-of-microtubules-in-cancer
#12
REVIEW
Luca Cirillo, Monica Gotta, Patrick Meraldi
Microtubules are the backbone of all eukaryotic cells cytoskeleton. Their dynamic behaviour constitutes the basis for many biological processes such as cellular motility, cytoplasmic transport and cell division. Some the most effective chemotherapeutics, such as the taxanes, are microtubule interfering drugs. Moreover, many studies suggest that microtubule dynamics are altered in cancer cell divisions and linked to chromosomal instability, aneuploidy and development of drug resistances. The elephant in the room, however, is that despite all these evidences, the exact role of microtubules in malignancies remains elusive, partially due to the lack of clear genetic alterations linking microtubules to cancer...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28481306/mth1-as-a-chemotherapeutic-target-the-elephant-in-the-room
#13
REVIEW
Govindi J Samaranayake, Mai Huynh, Priyamvada Rai
Many tumors sustain elevated levels of reactive oxygen species (ROS), which drive oncogenic signaling. However, ROS can also trigger anti-tumor responses, such as cell death or senescence, through induction of oxidative stress and concomitant DNA damage. To circumvent the adverse consequences of elevated ROS levels, many tumors develop adaptive responses, such as enhanced redox-protective or oxidatively-generated damage repair pathways. Targeting these enhanced oxidative stress-protective mechanisms is likely to be both therapeutically effective and highly specific to cancer, as normal cells are less reliant on such mechanisms...
May 8, 2017: Cancers
https://www.readbyqxmd.com/read/28344688/no-one-is-talking-about-the-elephant-in-the-room
#14
EDITORIAL
Marcel D'Eon
No abstract text is available yet for this article.
October 2016: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28333829/acute-traumatic-coagulopathy-the-elephant-in-a-room-of-blind-scientists
#15
REVIEW
Michael A Meledeo, Maryanne C Herzig, James A Bynum, Xiaowu Wu, Anand K Ramasubramanian, Daniel N Darlington, Kristin M Reddoch, Andrew P Cap
Acute traumatic coagulopathy (ATC) is the failure of coagulation homeostasis that can rapidly arise following traumatic injury, hemorrhage, and shock; it is associated with higher injury severity, coagulation abnormalities, and increased blood transfusions. Acute traumatic coagulopathy has historically been defined by a prolonged prothrombin time, although newer, more informative measurements of hemostatic function have been used to improve diagnosis and support clinical decision making. The underlying biochemical mechanisms of and best practice therapeutics for ATC remain under active investigation because of its significant correlation to poor outcomes...
June 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28291362/the-elephant-in-the-room-of-density-functional-theory-calculations
#16
Stig Rune Jensen, Santanu Saha, José A Flores-Livas, William Huhn, Volker Blum, Stefan Goedecker, Luca Frediani
Using multiwavelets, we have obtained total energies and corresponding atomization energies for the GGA-PBE and hybrid-PBE0 density functionals for a test set of 211 molecules with an unprecedented and guaranteed μHartree accuracy. These quasi-exact references allow us to quantify the accuracy of standard all-electron basis sets that are believed to be highly accurate for molecules, such as Gaussian-type orbitals (GTOs), all-electron numeric atom-centered orbitals (NAOs), and full-potential augmented plane wave (APW) methods...
March 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28275627/inappropriateness-in-laboratory-medicine-an-elephant-in-the-room
#17
Giuseppe Lippi, Chiara Bovo, Marcello Ciaccio
Appropriateness of diagnostic testing can be conventionally described as prescription of the right test, using the right method, at the right time, to the right patient, with the right costs and for producing the right outcome. There is ongoing debate about the real burden of inappropriateness in laboratory diagnostics. The media coverage of this issue has also recently led to either over- or under-emphasizing the clinical, organizational and economic consequences. This is quite problematic, inasmuch as some reliable data are available in the current scientific literature, showing that inappropriateness of laboratory testing can be as high as 70%...
February 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28251772/the-practice-gap-in-heart-failure-the-elephant-in-the-room
#18
Kenneth McDonald, Joe Gallagher
No abstract text is available yet for this article.
March 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28180119/nonemergent-patients-in-the-emergency-department-an-ethnographic-study
#19
Amir Mirhaghi, Abbas Heydari, Mohsen Ebrahimi, Mohsen Noghani Dokht Bahmani
BACKGROUND: Triage in the interactive atmosphere of the emergency department (ED) has been described as complex and challenging. Nonemergent ED visits have been accompanied by ethical and legal conflicts. OBJECTIVES: The aim of this study was to gain an understanding of ED nurses' practice regarding triage of nonemergent patients. PATIENTS AND METHODS: Focused micro-ethnography based on Spradley's developmental research sequence (DRS) was used...
September 2016: Trauma Monthly
https://www.readbyqxmd.com/read/28156552/the-elephant-in-the-room-facilitating-conversations-about-advanced-cancer-between-patients-and-their-spouses
#20
Laura FIsh, Hope Elizabeth Uronis, Yousuf Zafar, Karen E Steinhauser
233 Background: Interventions to enhance couples' communication about cancer-related issues can lead to benefits for patients, spouses, and their relationships. We recently conducted a pilot study testing a couples communication skills training (CCST) intervention targeted to couples in which one partner had advanced GI cancer, a population who may need particular help addressing difficult and emotionally-laden topics related to life-limiting illness. Results of quantitative analyses suggested that the intervention was effective in improving relationship satisfaction for these couples...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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