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The elephant in the room

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https://www.readbyqxmd.com/read/28600784/the-elephant-in-the-room-the-role-of-microtubules-in-cancer
#1
Luca Cirillo, Monica Gotta, Patrick Meraldi
Microtubules are the backbone of all eukaryotic cells cytoskeleton. Their dynamic behaviour constitutes the basis for many biological processes such as cellular motility, cytoplasmic transport and cell division. Some the most effective chemotherapeutics, such as the taxanes, are microtubule interfering drugs. Moreover, many studies suggest that microtubule dynamics are altered in cancer cell divisions and linked to chromosomal instability, aneuploidy and development of drug resistances. The elephant in the room, however, is that despite all these evidences, the exact role of microtubules in malignancies remains elusive, partially due to the lack of clear genetic alterations linking microtubules to cancer...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28481306/mth1-as-a-chemotherapeutic-target-the-elephant-in-the-room
#2
REVIEW
Govindi J Samaranayake, Mai Huynh, Priyamvada Rai
Many tumors sustain elevated levels of reactive oxygen species (ROS), which drive oncogenic signaling. However, ROS can also trigger anti-tumor responses, such as cell death or senescence, through induction of oxidative stress and concomitant DNA damage. To circumvent the adverse consequences of elevated ROS levels, many tumors develop adaptive responses, such as enhanced redox-protective or oxidatively-generated damage repair pathways. Targeting these enhanced oxidative stress-protective mechanisms is likely to be both therapeutically effective and highly specific to cancer, as normal cells are less reliant on such mechanisms...
May 8, 2017: Cancers
https://www.readbyqxmd.com/read/28344688/no-one-is-talking-about-the-elephant-in-the-room
#3
EDITORIAL
Marcel D'Eon
No abstract text is available yet for this article.
October 2016: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28333829/acute-traumatic-coagulopathy-the-elephant-in-a-room-of-blind-scientists
#4
Michael A Meledeo, Maryanne C Herzig, James A Bynum, Xiaowu Wu, Anand K Ramasubramanian, Daniel N Darlington, Kristin M Reddoch, Andrew P Cap
Acute traumatic coagulopathy (ATC) is the failure of coagulation homeostasis that can rapidly arise following traumatic injury, hemorrhage, and shock; it is associated with higher injury severity, coagulation abnormalities, and increased blood transfusions. Acute traumatic coagulopathy has historically been defined by a prolonged prothrombin time, although newer, more informative measurements of hemostatic function have been used to improve diagnosis and support clinical decision making. The underlying biochemical mechanisms of and best practice therapeutics for ATC remain under active investigation because of its significant correlation to poor outcomes...
June 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28291362/the-elephant-in-the-room-of-density-functional-theory-calculations
#5
Stig Rune Jensen, Santanu Saha, José A Flores-Livas, William Huhn, Volker Blum, Stefan Goedecker, Luca Frediani
Using multiwavelets, we have obtained total energies and corresponding atomization energies for the GGA-PBE and hybrid-PBE0 density functionals for a test set of 211 molecules with an unprecedented and guaranteed μHartree accuracy. These quasi-exact references allow us to quantify the accuracy of standard all-electron basis sets that are believed to be highly accurate for molecules, such as Gaussian-type orbitals (GTOs), all-electron numeric atom-centered orbitals (NAOs), and full-potential augmented plane wave (APW) methods...
March 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28275627/inappropriateness-in-laboratory-medicine-an-elephant-in-the-room
#6
Giuseppe Lippi, Chiara Bovo, Marcello Ciaccio
Appropriateness of diagnostic testing can be conventionally described as prescription of the right test, using the right method, at the right time, to the right patient, with the right costs and for producing the right outcome. There is ongoing debate about the real burden of inappropriateness in laboratory diagnostics. The media coverage of this issue has also recently led to either over- or under-emphasizing the clinical, organizational and economic consequences. This is quite problematic, inasmuch as some reliable data are available in the current scientific literature, showing that inappropriateness of laboratory testing can be as high as 70%...
February 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28251772/the-practice-gap-in-heart-failure-the-elephant-in-the-room
#7
Kenneth McDonald, Joe Gallagher
No abstract text is available yet for this article.
March 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28180119/nonemergent-patients-in-the-emergency-department-an-ethnographic-study
#8
Amir Mirhaghi, Abbas Heydari, Mohsen Ebrahimi, Mohsen Noghani Dokht Bahmani
BACKGROUND: Triage in the interactive atmosphere of the emergency department (ED) has been described as complex and challenging. Nonemergent ED visits have been accompanied by ethical and legal conflicts. OBJECTIVES: The aim of this study was to gain an understanding of ED nurses' practice regarding triage of nonemergent patients. PATIENTS AND METHODS: Focused micro-ethnography based on Spradley's developmental research sequence (DRS) was used...
September 2016: Trauma Monthly
https://www.readbyqxmd.com/read/28156552/the-elephant-in-the-room-facilitating-conversations-about-advanced-cancer-between-patients-and-their-spouses
#9
Laura FIsh, Hope Elizabeth Uronis, Yousuf Zafar, Karen E Steinhauser
233 Background: Interventions to enhance couples' communication about cancer-related issues can lead to benefits for patients, spouses, and their relationships. We recently conducted a pilot study testing a couples communication skills training (CCST) intervention targeted to couples in which one partner had advanced GI cancer, a population who may need particular help addressing difficult and emotionally-laden topics related to life-limiting illness. Results of quantitative analyses suggested that the intervention was effective in improving relationship satisfaction for these couples...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28139063/lignin-depolymerisation-and-lignocellulose-fractionation-by-solvated-electrons-in-liquid-ammonia
#10
Pepijn Prinsen, Anand Narani, Gadi Rothenberg
We explored the depolymerisation of several lignins in liquid ammonia at relatively high temperatures and pressures (120 °C and 88 bar). Five different lignins were tested: Indulin AT kraft, Protobind 1000 soda, wheat straw organosolv, poplar organosolv and elephant grass-milled wood lignin (EG MWL). In pure liquid ammonia, all lignins underwent slow incorporation of nitrogen into their structure, resulting in higher molecular weight and polydispersity index. Subsequently, we show a reductive depolymerisation by solvated electrons at room temperature by adding sodium metal to the liquid ammonia without any external hydrogen donor...
March 9, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28130318/commentary-on-protect-our-children-the-elephant-in-the-room
#11
Jane E Ferrie
No abstract text is available yet for this article.
December 1, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27992095/faecal-occult-blood-testing-screening-for-colorectal-cancer-and-missed-interval-cancers-are-we-ignoring-the-elephant-in-the-room-results-of-a-multicentre-study
#12
A T George, S Aggarwal, S Dharmavaram, A Menon, M Dube, M Vogler, A Field
AIM: Biennial faecal occult blood testing (FOBT) is used to screen for colorectal cancer throughout the UK. Interval cancers are tumours that develop in patients between screening rounds who have had a negative FOBT. Through a multicentre study, we compared the demographics of patients with interval cancers, FOBT screen detected cancers and cancers that developed in patients who chose not to participate in the screening programme. METHOD: Five hundred and sixteen colorectal cancers were detected in the screening age group (60-74 years) population in three UK National Health Service hospitals over 2 years...
May 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27893911/retraining-the-elephants-in-the-room
#13
EDITORIAL
Patricia S Yoder-Wise
No abstract text is available yet for this article.
December 1, 2016: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/27852612/the-elephant-in-the-room-using-nutritional-biomarker-cutoffs-to-assess-status
#14
Amanda J MacFarlane
No abstract text is available yet for this article.
December 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27842686/aortic-root-surgery-for-young-patients-the-elephant-in-the-room
#15
EDITORIAL
John R Doty
No abstract text is available yet for this article.
December 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27817088/the-elephant-in-the-room-talking-race-in-medical-education
#16
Malika Sharma, Ayelet Kuper
The deaths of black men and women while in police custody, rising anti-immigrant sentiment and rhetoric in high-income countries, and the continued health disparities experienced by Indigenous communities globally have brought race and racism to the forefront of public discourse in recent years. In a context where academic health science centres are increasingly called to be "socially accountable," ignoring the larger social context of race and racism is something that medical education institutions can little afford to do...
November 5, 2016: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/27777181/home-visits-are-needed-to-address-asthma-health-disparities-in-adults
#17
Tyra Bryant-Stephens, Shakira Reed-Wells, Maryori Canales, Luzmercy Perez, Marisa Rogers, A Russell Localio, Andrea J Apter
Research on asthma frequently recruits patients from clinics because the ready pool of patients leads to easy access to patients in office waiting areas, emergency departments, or hospital wards. Patients with other chronic conditions, and with mobility problems, face exposures at home that are not easily identified at the clinic. In this article, we describe the perspective of the community health workers and the challenges they encountered when making home visits while implementing a research intervention in a cohort of low-income, minority patients...
December 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27766285/acknowledging-the-elephant-in-the-room-how-stressful-environmental-contexts-shape-relationship-dynamics
#18
Lisa A Neff, Benjamin R Karney
Compared to affluent marriages, lower income marriages develop within a context filled with negative stressors that may prove quite toxic for marital stability. The current paper argues that stressful contexts may undermine marital well-being through two routes. First, external stressors create additional problems within the marriage by diverting time and attention away from activities that promote intimacy between partners. Second, external stress may render spouses ill-equipped to cope with this increase in problems by draining spouses of the energy and resources necessary for responding to marital challenges in a constructive manner...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/27723888/congenital-cytomegalovirus-infection-the-elephant-in-our-living-room
#19
Gail J Demmler-Harrison
No abstract text is available yet for this article.
December 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27720399/becoming-a-sexual-being-the-elephant-in-the-room-of-adolescent-brain-development
#20
REVIEW
Ahna Ballonoff Suleiman, Adriana Galván, K Paige Harden, Ronald E Dahl
The onset of adolescence is a time of profound changes in motivation, cognition, behavior, and social relationships. Existing neurodevelopmental models have integrated our current understanding of adolescent brain development; however, there has been surprisingly little focus on the importance of adolescence as a sensitive period for romantic and sexual development. As young people enter adolescence, one of their primary tasks is to gain knowledge and experience that will allow them to take on the social roles of adults, including engaging in romantic and sexual relationships...
June 2017: Developmental Cognitive Neuroscience
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