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The elephant in the room

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https://www.readbyqxmd.com/read/29139332/the-views-of-adults-with-huntington-s-disease-on-assisted-dying-a-qualitative-exploration
#1
Laurence Regan, Nancy J Preston, Fiona J R Eccles, Jane Simpson
BACKGROUND: Assisted dying is frequently debated publicly and research often includes the views of health professionals on this issue. However, the views of people with life-limiting conditions, for whom this issue is likely to have a different resonance, are less well represented. AIM: The purpose of this study was to explore the views of people who live with the inevitability of developing Huntington's disease, a genetically transmitted disease which significantly limits life, on assisted dying...
November 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29128870/microbiological-and-chemical-profiles-of-elephant-grass-inoculated-with-and-without-lactobacillus-plantarum-and-pediococcus-acidilactici
#2
Assar Ali Shah, Yuan Xianjun, Dong Zhihao, Li Junfeng, Tao Sao
The study was conducted to evaluate the microbiological and chemical profiles of elephant grass inoculated with and without different wild strains of lactic acid bacteria. Silage was prepared of four treatments and one control with three replicates as control (EKC, adding 2 ml/kg sterilizing water), Lactobacillus plantarum (USA commercial bacteria) (EKP), Lactobacillus plantarum (EKA), Pediococcus acidilactici (EKB), and Pediococcus acidilactici (SKD) isolated from King grass. Silage were prepared using polyethylene terephthalate bottles, and incubated at room temperature for different ensiling days...
November 11, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/29042464/recognizing-the-elephant-in-the-room-palliative-care-needs-in-acute-kidney-injury
#3
EDITORIAL
Amar D Bansal, Jane O Schell
No abstract text is available yet for this article.
November 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29038383/biological-effects-of-mri-contrast-agents-gadolinium-retention-potential-mechanisms-and-a-role-for-phosphorus
#4
REVIEW
Joel Garcia, Stephen Z Liu, Angelique Y Louie
No discussion of challenges for chemistry in molecular imaging would be complete without addressing the elephant in the room-which is that the purest of chemical compounds needs to interact with a biological system in a manner that does not perturb normal biology while still providing efficacious feedback to assist in diagnosis of disease. In the past decade, magnetic resonance imaging (MRI) agents long considered inert have produced adverse effects in certain patient populations under certain treatment regimens...
November 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29036444/the-elephant-in-the-room-toward-a-more-ethical-approach-with-accountability-toward-intended-beneficiaries-in-humanitarian-aid
#5
Ramin Asgary, Ronald J Waldman
There is considerable tension between the concept of accountability to beneficiaries and its practice in humanitarian aid. The beneficiaries live in a relationship that is asymmetric; upward or horizontal accountability within the aid system alone-even with the best of intentions-might be short-sighted. Could beneficiaries be effectively involved in programing, priority setting or allocation of resources? Is there space for a rights-based approach in aid delivery and operations? The mind-set, governance and structure of operations in aid agencies may need significant institutional reform to share the process of decision-making, and to transform the current dynamic from connecting resources to brokering better governance, true collaboration and co-operation among all stakeholders...
September 28, 2017: International Health
https://www.readbyqxmd.com/read/28969985/pml-risk-and-natalizumab-the-elephant-in-the-room
#6
Tobias Derfuss, Ludwig Kappos
No abstract text is available yet for this article.
November 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28967780/the-elephant-in-the-room-inconsistency-in-scene-viewing-and-representation
#7
Sara Spotorno, Benjamin W Tatler
We examined the extent to which semantic informativeness, consistency with expectations and perceptual salience contribute to object prioritization in scene viewing and representation. In scene viewing (Experiments 1-2), semantic guidance overshadowed perceptual guidance in determining fixation order, with the greatest prioritization for objects that were diagnostic of the scene's depicted event. Perceptual properties affected selection of consistent objects (regardless of their informativeness) but not of inconsistent objects...
October 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28957993/an-international-perspective-on-chronic-multimorbidity-approaching-the-elephant-in-the-room
#8
Davide L Vetrano, Amaia Calderón-Larrañaga, Alessandra Marengoni, Graziano Onder, Jürgen M Bauer, Matteo Cesari, Luigi Ferrucci, Laura Fratiglioni
Multimorbidity is a common and burdensome condition that may affect quality of life, increase medical needs and make people live more years of life with disability. Negative outcomes related to multimorbidity occur beyond what we would expect from the summed effect of single conditions, as chronic diseases interact with each other, mutually enhancing their negative effects, and eventually leading to new clinical phenotypes. Moreover, multimorbidity mirrors an accelerated global susceptibility and a loss of resilience, which are both hallmarks of aging...
September 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28929908/dissociative-and-complex-trauma-disorders-in-health-and-mental-health-contexts-or-why-is-the-elephant-not-in-the-room
#9
Kevin J Connors
No abstract text is available yet for this article.
September 20, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28864753/bipolar-disorder-and-addictions-the-elephant-in-the-room
#10
EDITORIAL
Paul R A Stokes, Nicola J Kalk, Allan H Young
Addictions are highly prevalent in bipolar disorder and greatly affect clinical outcomes. In this editorial, we review the evidence that addictions are a key challenge in bipolar disorder, examine putative neurobiological mechanisms, and reflect on the limited clinical trial evidence base with suggestions for treatment strategies and further developments.
September 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28813169/the-elephant-in-the-room
#11
Joan E Dodgson
No abstract text is available yet for this article.
August 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28812848/the-elephants-in-the-room-sex-hiv-and-lgbt-populations-in-mena-intersectionality-in-lebanon-comment-on-improving-the-quality-and-quantity-of-hiv-data-in-the-middle-east-and-north-africa-key-challenges-and-ways-forward
#12
Rachel L Kaplan, Cynthia El Khoury
In response to this insightful editorial, we wish to provide commentary that seeks to highlight recent successes and illuminate the often unspoken hurdles at the intersections of culture, politics, and taboo. We focus on sexual transmission and draw examples from Lebanon, where the pursuit of data in quality and quantity is teaching us lessons about the way forward and where we are experiencing many of the challenges referenced in the editorial such as discrepancies between national statistics and rates derived via research as well as the impact of protracted political conflict and displacement...
December 4, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28797283/incident-gout-and-erectile-dysfunction-is-hyperuricaemia-the-elephant-in-the-room
#13
EDITORIAL
Abhishek Abhishek, Michael Doherty
The first prospective population-based study to examine risk of erectile dysfunction in men with gout in the western world has been published. It reports that following their first diagnosis of gout, men have a 31% higher risk of erectile dysfunction than matched controls, although the absolute increase in risk is small. Of interest, the incidence of erectile dysfunction reported in this study is tenfold higher than those reported in nation-wide cohort studies from Taiwan. There is a need for further prospective cohort studies to examine the possible mechanistic association between gout, hyperuricaemia and erectile dysfunction...
August 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28765235/letter-to-the-editor-auc-for-v-q-imaging-in-pulmonary-embolism-the-elephant-in-the-room-planar-or-spect-v-q
#14
Pierre-Yves Le Roux, Pierre-Yves Salaun
No abstract text is available yet for this article.
August 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28747016/unveiling-the-elephant-in-the-room-the-dilemma-of-patients-managed-medically-after-non-st-segment-elevation-acute-coronary-syndromes
#15
EDITORIAL
David Eccleston
No abstract text is available yet for this article.
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28739107/hydrostatic-pressure-and-the-experimental-toxicology-of-marine-fishes-the-elephant-in-the-room
#16
Benjamin Lemaire
Hydrostatic pressure (HP) increases linearly with depth in aquatic environments, so that many fish species routinely experience moderate-to-high HP levels (i.e., from a few to dozens of MPa). Biological effects of this thermodynamic variable are evidenced by a reduced functionality of many biomolecular systems, even in barotolerant and barophilic species. It is likely that environmentally-relevant HP levels (i.e., above atmospheric) could also modulate the responsiveness to and toxic effects of pollutants in fish...
July 21, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28722449/how-large-is-the-elephant-in-the-density-functional-theory-room
#17
Frank Jensen
A recent paper reported highly accurate density functional theory results for atomization energies and dipole moments using a multiwavelet-based method and compared the results with those obtained by standard Gaussian basis sets of the aug-cc-pVXZ type. Typical errors with the large aug-cc-pV5Z basis set were in the 0.2 kcal/mol range with outliers displaying errors of ∼2 kcal/mol, and these results could be taken as an indication that Gaussian basis sets in general are unsuitable for achieving high accuracy...
August 3, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28721021/addressing-the-elephant-in-the-room-a-possible-new-way-to-increase-patient-adherence-to-medical-advice
#18
Gudmund Grønhaug
Lack of patient adherence to medical advice (PAMA) is recognized as an area of interest. None of the previous initiatives to improve PAMA, such as patient centered care and shared decision making, have proved to be successful in terms of improving patient adherence. The aim of the present study is to assess beliefs about priorities in public health care, and adherence to medical advice, to establish a novel approach to increase PAMA. The present study is based on responses to two questions in an experimental survey from the Norwegian Citizen Panel, addressing people's attitudes to priorities in public health care and adherence to medical advice...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28656582/an-historical-perspective-of-the-discovery-of-titin-filaments
#19
REVIEW
Cris Dos Remedios, Darcy Gilmour
This review takes readers back to 1949, when two Australian scientists, Draper and Hodge, reported the first high-resolution electron microscopy images of striated muscle. In 1953, Jean Hanson and Hugh Huxley published phase-contrast microscopy and electron microscopy images that established the filamentous nature of the sarcomere, namely the myosin-containing thick filaments and actin-containing thin filaments. They discussed a putative third filament system, possibly a thinner actin-containing S filament, that appeared to connect one Z disc to the next...
June 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28600784/the-elephant-in-the-room-the-role-of-microtubules-in-cancer
#20
REVIEW
Luca Cirillo, Monica Gotta, Patrick Meraldi
Microtubules are the backbone of all eukaryotic cells cytoskeleton. Their dynamic behaviour constitutes the basis for many biological processes such as cellular motility, cytoplasmic transport and cell division. Some the most effective chemotherapeutics, such as the taxanes, are microtubule interfering drugs. Moreover, many studies suggest that microtubule dynamics are altered in cancer cell divisions and linked to chromosomal instability, aneuploidy and development of drug resistances. The elephant in the room, however, is that despite all these evidences, the exact role of microtubules in malignancies remains elusive, partially due to the lack of clear genetic alterations linking microtubules to cancer...
2017: Advances in Experimental Medicine and Biology
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