keyword
https://read.qxmd.com/read/38536451/helmet-therapy-efficacy-and-its-prediction-in-japanese-infants-with-positional-plagio-and-brachycephaly
#1
JOURNAL ARTICLE
Yasuo Aihara, Kentaro Chiba, Takakazu Kawamata
PURPOSE: To provide additional information on optimal start times and therapeutic effectiveness based on treatment outcome of Japanese infants with positional plagio- and brachycephaly (PPB) receiving cranial molding helmet therapy (CMHT). METHODS: In this retrospective cohort study, data from a 3D head scanning system was analyzed from 2173 Japanese infants who completed CMHT. Anterior and posterior symmetry ratio (ASR and PSR) and longitudinal to transverse diagonal ratios (LD/TDR) were calculated based on skull shape at helmet design and at completion of therapy...
March 27, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38536029/a-vaginal-birth-is-a-cost-reduction-strategy-for-women-with-a-low-lying-placenta
#2
JOURNAL ARTICLE
Elisabetta Colciago, Pietro Ferrara, Isadora Vaglio Tessitore, Lorenzo G Mantovani, Patrizia Vergani, Sara Ornaghi
BACKGROUND: Alongside health consequences, cesarean delivery (CD) has been associated with increased healthcare resource utilization (HCRU). A CD should be performed in case of placenta previa; in turn, the most appropriate mode of birth in women with a low-lying placenta (LLP) is still controversial. Since no previous data are available on the topic, the aim of this study was to evaluate the HCRU and economic impact on the Italian HC system of vaginal birth (VB) and CD in women with a LLP...
March 27, 2024: Minerva obstetrics and gynecology
https://read.qxmd.com/read/38535814/development-of-a-rapid-and-sensitive-canary-biosensor-assay-for-the-detection-of-shiga-toxin-2-from-escherichia-coli
#3
JOURNAL ARTICLE
Christina C Tam, Yangyang Wang, Wen-Xian Du, Andrew R Flannery, Xiaohua He
Shiga-toxin-producing Escherichia coli (STEC) causes a wide spectrum of diseases including hemorrhagic colitis and hemolytic uremic syndrome (HUS). The current Food Safety Inspection Service (FSIS) testing methods for STEC use the Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) protocol, which includes enrichment, cell plating, and genomic sequencing and takes time to complete, thus delaying diagnosis and treatment. We wanted to develop a rapid, sensitive, and potentially portable assay that can identify STEC by detecting Shiga toxin (Stx) using the CANARY (Cellular Analysis and Notification of Antigen Risks and Yields) B-cell based biosensor technology...
March 14, 2024: Toxins
https://read.qxmd.com/read/38535262/formulative-study-and-characterization-of-novel-biomaterials-based-on-chitosan-hydrolyzed-collagen-films
#4
JOURNAL ARTICLE
Tomás Martínez Rodríguez, Caterina Valentino, Francisco Ramón Rodríguez Pozo, Pablo Hernández Benavides, Francisco Arrebola Vargas, José Manuel Paredes, Claro Ignacio Sainz-Díaz, Guillermo R Iglesias, Silvia Rossi, Giuseppina Sandri, María Del Mar Medina Pérez, Carola Aguzzi
To date, the need for biomaterials capable of improving the treatment of chronic skin wounds remains a clinical challenge. The aim of the present work is to formulate and characterize chitosan (Cs)/hydrolyzed collagen (HC) films as potential biomaterials with improved mechanical and hydration performances compared to single component formulations. Films were made by the solvent casting method, with or without glycerin and/or PEG1500 as plasticizers, resulting in a total of eight formulations. All films were characterized by their physico-chemical characteristics and their mechanical and hydration features...
March 11, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535061/thoracic-biometry-in-patients-with-congenital-diaphragmatic-hernia-a-magnetic-resonance-imaging-study
#5
JOURNAL ARTICLE
Erick George Neștianu, Septimiu Popescu, Dragoș Ovidiu Alexandru, Laura Giurcăneanu, Radu Vlădăreanu
This is a retrospective study investigating biometric measurements using magnetic resonance imaging (MRI) examinations in congenital diaphragmatic hernia (CDH). CDH is one of the more common causes of pulmonary hypoplasia, with grave consequences for the fetus. Inclusion criteria were patients diagnosed with CDH as the only observed anomaly, who underwent MRI examination after the second-trimester morphology ultrasound. The patients came from three university hospitals in Bucharest, Romania. In total, 19 patients were included in the study after applying exclusion criteria...
March 18, 2024: Diagnostics
https://read.qxmd.com/read/38534988/structural-brain-connectivity-and-treatment-improvement-in-mood-disorder
#6
JOURNAL ARTICLE
Sébastien Dam, Jean-Marie Batail, Gabriel Hadrien Robert, Dominique Drapier, Pierre Maurel, Julie Coloigner
BACKGROUND: The treatment of depressive episodes is well established, with clearly demonstrated effectiveness of antidepressants and psychotherapies. However, more than one-third of depressed patients do not respond to treatment. Identifying the brain structural basis of treatment-resistant depression could prevent useless pharmacological prescriptions, adverse events, and lost therapeutic opportunities. METHODS: Using diffusion magnetic resonance imaging, we performed structural connectivity analyses on a cohort of 154 patients with mood disorder (MD) - and 77 sex- and age-matched healthy control (HC) participants...
March 27, 2024: Brain Connectivity
https://read.qxmd.com/read/38534967/amino-acid-metabolism-in-leukocytes-showing-in-vitro-igg-memory-from-sars-cov2-infected-patients
#7
REVIEW
Giuseppina Fanelli, Veronica Lelli, Sara Rinalducci, Anna Maria Timperio
The immune response to infectious diseases is directly influenced by metabolic activities. COVID-19 is a disease that affects the entire body and can significantly impact cellular metabolism. Recent studies have focused their analysis on the potential connections between post-infection stages of SARS-CoV2 and different metabolic pathways. The spike S1 antigen was found to have in vitro IgG antibody memory for PBMCs when obtaining PBMC cultures 60-90 days post infection, and a significant increase in S-adenosyl homocysteine, sarcosine, and arginine was detected by mass spectrometric analysis...
February 23, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534777/the-nlrp3-inflammasome-gene-is-overexpressed-in-hidradenitis-suppurativa-lesions-a-preliminary-study-on-the-role-of-pyroptosis-in-disease-pathogenesis
#8
JOURNAL ARTICLE
Piotr K Krajewski, Weronika Szukała, Jacek C Szepietowski
Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disorder, and its pathogenesis remains incompletely understood. This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA sequencing and real-time PCR were performed to assess the gene expression levels of P2X7R and NLRP3 in the skin biopsies of HS patients and healthy controls (HC). The results of our study revealed a significantly increased expression of the NLRP3 gene in both the lesional and perilesional skin of HS patients compared to healthy controls...
March 16, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534611/thermosensitive-in-situ-gelling-poloxamers-hyaluronic-acid-gels-for-hydrocortisone-ocular-delivery
#9
JOURNAL ARTICLE
Fabrizio Villapiano, Teresa Silvestri, Camilla Lo Gatto, Danilo Aleo, Virginia Campani, Sossio Fabio Graziano, Concetta Giancola, Federica D'Aria, Giuseppe De Rosa, Marco Biondi, Laura Mayol
This study endeavored to overcome the physiological barriers hindering optimal bioavailability in ophthalmic therapeutics by devising drug delivery platforms that allow therapeutically effective drug concentrations in ocular tissues for prolonged times. Thermosensitive drug delivery platforms were formulated by blending poloxamers (F68 and F127) with low-molecular-weight hyaluronic acid (HA) in various concentrations and loaded with hydrocortisone (HC). Among the formulations examined, only three were deemed suitable based on their desirable gelling properties at a temperature close to the eye's surface conditions while also ensuring minimal gelation time for swift ocular application...
March 12, 2024: Gels
https://read.qxmd.com/read/38534331/low-density-lipoprotein-cholesterol-decreases-the-expression-of-adenosine-a-2a-receptor-and-lipid-rafts-protein-flotillin-1-insights-on-cardiovascular-risk-of-hypercholesterolemia
#10
JOURNAL ARTICLE
Marie-Charlotte Chaptal, Marie Maraninchi, Giorgia Musto, Julien Mancini, Hedi Chtioui, Janine Dupont-Roussel, Marion Marlinge, Julien Fromonot, Nathalie Lalevee, Florian Mourre, Sophie Beliard, Régis Guieu, René Valero, Giovanna Mottola
High blood levels of low-density lipoprotein (LDL)-cholesterol (LDL-C) are associated with atherosclerosis, mainly by promoting foam cell accumulation in vessels. As cholesterol is an essential component of cell plasma membranes and a regulator of several signaling pathways, LDL-C excess may have wider cardiovascular toxicity. We examined, in untreated hypercholesterolemia (HC) patients, selected regardless of the cause of LDL-C accumulation, and in healthy participants (HP), the expression of the adenosine A2A receptor (A2A R), an anti-inflammatory and vasodilatory protein with cholesterol-dependent modulation, and Flotillin-1, protein marker of cholesterol-enriched plasma membrane domains...
March 11, 2024: Cells
https://read.qxmd.com/read/38534322/blood-markers-show-neural-consequences-of-longcovid-19
#11
JOURNAL ARTICLE
Norina Tang, Tatsuo Kido, Jian Shi, Erin McCafferty, Judith M Ford, Kaitlyn Dal Bon, Lynn Pulliam
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persists throughout the world with over 65 million registered cases of survivors with post-COVID-19 sequelae, also known as LongCOVID-19 (LongC). LongC survivors exhibit various symptoms that span multiple organ systems, including the nervous system. To search for neurological markers of LongC, we investigated the soluble biomolecules present in the plasma and the proteins associated with plasma neuronal-enriched extracellular vesicles (nEVs) in 33 LongC patients with neurological impairment (nLongC), 12 COVID-19 survivors without any LongC symptoms (Cov), and 28 pre-COVID-19 healthy controls (HC)...
March 8, 2024: Cells
https://read.qxmd.com/read/38533808/the-potential-effect-of-garlium-gem-hc-tm-as-a-tick-control-agent-in-cattle
#12
JOURNAL ARTICLE
F M Hagg, L J Erasmus, W H Stoltsz
As resistance to chemical acaricides increases amongst tick populations, investigations of natural remedies that have acaricidal or tick-repellent effects have become essential in the search for alternatives for sustainable tick control. Garlium GEM HC (Garlium), a natural concentrated garlic product, was supplemented in-feed to beef cattle to determine if it could assist in reducing the number of attached ticks on cattle. Two grams of Garlium was supplemented daily to eight Bonsmara steers over 43 days. A second group of eight steers served as controls...
March 26, 2024: Journal of the South African Veterinary Association
https://read.qxmd.com/read/38533447/research-on-adults-with-subthreshold-depression-after-aerobic-exercise-a-resting-state-fmri-study-based-on-regional-homogeneity-reho
#13
JOURNAL ARTICLE
Wenbin Shen, Xiaoxiao Wang, Qin Li, Qingguo Ding, Hongqiang Zhang, Zheng Qian, Zhixin Sun, Xingyu Chen, Jun Zhang, Mengqi Zhao, Lina Huang, Wei Xing
OBJECTIVE: Subthreshold depression (StD)/subsyndromal depression refers to a threatening precursor to depression. Aerobic exercise is a promising self-supportive adjunctive intervention and an effective measure for StD. Our study utilizes regional homogeneity (ReHo) to investigate the impact of aerobic exercise on resting-state brain function. METHODS: A total of 78 subjects, aged between 18 and 48 years, (StD group, n = 44; healthy control (HC) group, n = 34) engaged in moderate-intensity aerobic exercise 3-4 times per week for 8 weeks...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38533444/small-size-big-problems-insights-and-difficulties-in-prenatal-diagnosis-of-fetal-microcephaly
#14
REVIEW
Leila Haddad, Efrat Hadi, Zvi Leibovitz, Dorit Lev, Yoseph Shalev, Liat Gindes, Tally Lerman-Sagie
Microcephaly is a sign, not a diagnosis. Its incidence varies widely due to the differences in the definition and the population being studied. It is strongly related to neurodevelopmental disorders. Differences in definitions and measurement techniques between fetuses and newborns pose a great challenge for the diagnosis and prognostication of fetal microcephaly. A false positive diagnosis can result (in countries where it is legal) in erroneous termination of pregnancy, where a false negative diagnosis might lead to the birth of a microcephalic newborn...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38533096/the-influence-of-plastic-pyrolysis-oil-on-fuel-lubricity-and-diesel-engine-performance
#15
JOURNAL ARTICLE
Anupap Pumpuang, Niti Klinkaew, Khatha Wathakit, Aunna Sukhom, Ekarong Sukjit
This study investigates the viability of using plastic oils derived from High-density polyethylene (HDPE), Polypropylene (PP), and Polystyrene (PS) as alternative fuels for diesel engines. The research focuses on comparing the physical and chemical properties, fuel lubricity, engine performance, combustion characteristics, and exhaust emissions of these plastic oils. Analysis revealed that PS exhibits different fuel properties compared to diesel, with a carbon range distribution similar to gasoline, while HDPE and PP properties closely resemble diesel fuel...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38532631/the-hadley-circulation-in-a-changing-climate
#16
REVIEW
Piero Lionello, Roberta D'Agostino, David Ferreira, Hanh Nguyen, Martin S Singh
The Hadley circulation (HC) is a global-scale atmospheric feature with air descending in the subtropics and ascending in the tropics, which plays a fundamental role in Earth's climate because it transports energy polewards and moisture equatorwards. Theoretically, as a consequence of anthropogenic climate change, the HC is expected to expand polewards, while indications on the HC strength are equivocal, as weakening and strengthening are expected in response to different mechanisms. In fact, there is a general agreement among reanalyses and climate simulations that the HC has significantly widened in the last four decades and it will continue widening in the future, but there is no consensus on past and future changes of the HC strength...
March 26, 2024: Annals of the New York Academy of Sciences
https://read.qxmd.com/read/38532568/alterations-of-circulating-free-fatty-acids-in-patients-with-pemphigus-vulgaris
#17
JOURNAL ARTICLE
Roberto Maglie, Simone Baldi, Giulia Nannini, Leandro Di Gloria, Marco Pallecchi, Gianluca Bartolucci, Matteo Ramazzotti, Elena Niccolai, Maria Efenesia Baffa, Biagioni Camilla, Farzan Solimani, Emiliano Antiga, Amedeo Amedei
Free fatty acids (FFA) have gained research interest owing to their functions in both local and systemic immune regulation. Changes in the serum levels of anti-inflammatory short chain fatty acids (SCFA), primarily derived from the gut microbiota, and pro-inflammatory medium (MCFA) and long (LCFA) chain fatty acids, derived from either the gut microbiota or the diet, have been associated with autoimmunity. Circulating FFA were retrospectively analysed by a gas chromatography-mass spectrometry method in the serum of 18 patients with pemphigus vulgaris (PV) at the baseline and 6 months (n = 10) after immunosuppressive treatments, and 18 healthy controls (HC)...
March 2024: Experimental Dermatology
https://read.qxmd.com/read/38532419/identification-of-novel-protein-biomarkers-from-the-blood-and-urine-for-the-early-diagnosis-of-bladder-cancer-via-proximity-extension-analysis
#18
JOURNAL ARTICLE
Tong Kong, Yang Qu, Taowa Zhao, Zitong Niu, Xiuyi Lv, Yiting Wang, Qiaojiao Ding, Pengyao Wei, Jun Fu, Liang Wang, Jing Gao, Cheng Zhou, Suying Wang, Junhui Jiang, Jianping Zheng, Kaizhe Wang, Kerong Wu
BACKGROUND: Bladder cancer (BC) is a very common urinary tract malignancy that has a high incidence and lethality. In this study, we identified BC biomarkers and described a new noninvasive detection method using serum and urine samples for the early detection of BC. METHODS: Serum and urine samples were retrospectively collected from patients with BC (n = 99) and healthy controls (HC) (n = 50), and the expression levels of 92 inflammation-related proteins were examined via the proximity extension analysis (PEA) technique...
March 26, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38532335/abnormal-ambiguous-facial-expression-recognition-in-chinese-patients-with-schizophrenia
#19
JOURNAL ARTICLE
Xiaoli Lyu, Yuyan Chi, Zhenyu Wang, Xinyan Shao, Guangya Zhang, Chuanwei Li, Chenglong Dong, Xuqin Wang, Xin Li, Chuanlin Zhu, Xiaofeng Xu, Xiangdong Du
BACKGROUND: Patients with schizophrenia (SCZ) exhibit difficulties deficits in recognizing facial expressions with unambiguous valence. However, only a limited number of studies have examined how these patients fare in interpreting facial expressions with ambiguous valence (for example, surprise). Thus, we aimed to explore the influence of emotional background information on the recognition of ambiguous facial expressions in SCZ. METHODS: A 3 (emotion: negative, neutral, and positive) × 2 (group: healthy controls and SCZ) experimental design was adopted in the present study...
March 26, 2024: BMC Psychiatry
https://read.qxmd.com/read/38531978/homocysteine-metabolites-inhibit-autophagy-by-upregulating-mir-21-5p-mir-155-5p-mir-216-5p-and-mir-320c-3p-in-human-vascular-endothelial-cells
#20
JOURNAL ARTICLE
Łukasz Witucki, Hieronim Jakubowski
Nutritional and genetic deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis, which is a major cause of cardiovascular disease (CVD). Impaired autophagy causes the accumulation of damaged proteins and organelles and is associated with CVD. Biochemically, HHcy is characterized by elevated levels of Hcy and its metabolites, Hcy-thiolactone and N-Hcy-protein. However, whether these metabolites can dysregulate mTOR signaling and autophagy in endothelial cells is not known...
March 26, 2024: Scientific Reports
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