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https://www.readbyqxmd.com/read/28918367/25-hydroxycholesterol-and-inflammation-in-lovastatin-deregulated-mevalonate-pathway
#1
Paola Maura Tricarico, Rossella Gratton, Luca Braga, Fulvio Celsi, Sergio Crovella
Mevalonate pathway deregulation has been observed in several diseases, including Mevalonate kinase deficiency (MKD). MKD is a hereditary auto-inflammatory disorder, due to mutations at mevalonate kinase gene (MVK), encoding mevalonate kinase (MK) enzyme. MVK mutations have been reported as associated with impairment of mevalonate pathway with consequent decrease of protein prenylation levels, defective autophagy and increase of IL-1β secretion, followed by cell death. Since 25-hydroxycholesterol (25-HC), a metabolite of cholesterol, can suppress IL-1β production, thus reducing inflammation, we evaluated the effect of 25-HC in an in vitro model of mevalonate pathway alteration, obtained using Lovastatin...
September 13, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28918343/emotion-and-self-in-psychotic-disorders-behavioral-evidence-from-an-emotional-evaluation-task-using-verbal-stimuli-varying-in-emotional-valence-and-self-reference
#2
Cornelia Herbert, Klaus Hesse, Dirk Wildgruber
BACKGROUND AND OBJECTIVES: Psychotic disorders are accompanied by changes in emotional and self-referential processing. This behavioral study investigates the link between emotional and self-referential processing in 21 psychotic patients with and without symptoms of disordered self-processing and 21 healthy age-matched controls during emotional evaluation of words varying in emotional valence and self-reference. METHODS: Emotional and neutral words related to the self of the reader (e...
September 5, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28918162/how-high-level-of-anxiety-in-panic-disorder-can-interfere-in-working-memory-a-computer-simulation-and-electrophysiological-investigation
#3
Luiza Wanick Di Giorgio Silva, Danielle Aprigio, Jesse Di Giacomo, Mariana Gongora, Henning Budde, Juliana Bittencourt, Mauricio Cagy, Silmar Teixeira, Pedro Ribeiro, Marcele Regine de Carvalho, Rafael Freire, Antonio Egidio Nardi, Luis Fernando Basile, Bruna Velasques
Panic disorder (PD) is characterized by repeated and unexpected attacks of intense anxiety, which are not restricted to a determined situation or circumstance. The coherence function has been used to investigate the communication among brain structures through the quantitative EEG (qEEG). The objective of this study is to analyze if there is a difference in frontoparietal gamma coherence (GC) between panic disorder patients (PDP) and healthy controls (HC) during the Visual oddball paradigm; and verify if high levels of anxiety (produced by a computer simulation) affect PDP's working memory...
September 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28917818/assessment-of-shipping-emissions-on-four-ports-of-portugal
#4
R A O Nunes, M C M Alvim-Ferraz, F G Martins, S I V Sousa
In the last few years, ship emissions have attracted growing attention in the scientific community. The main reason is the constant increase of marine emissions over the last twenty years due to the intensification of port traffic. Thus, this study aimed to evaluate ship emissions (PM10, PM2.5, NOx, SO2, CO, CO2, N2O CH4, NMVOC, and HC) through the activity-based methodology in four of the main ports of Portugal (Leixões, Setúbal, Sines and Viana do Castelo) during 2013 and 2014. The analysis was performed according to ship types (bulk carrier, container, general cargo, passenger, Ro-Ro cargo, tanker and others) and operational modes (manoeuvring, hotelling and during cruising)...
September 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28914871/-intramedullary-spinal-cord-tumors-and-hydrocephalus-an-analysis-of-the-results-of-surgical-treatment-in-541-patients
#5
Yu V Kushel', Yu D Belova, A R Tekoev
The article addresses the problem of intramedullary tumors (IMTs) combined with hydrocephalus (HC). PURPOSE: The study purpose was to explore, based on large clinical material, the occurrence of hydrocephalus combined with intramedullary tumors, possible pathogenetic mechanisms of its development, effect of tumor resection on the course of hydrocephalus, and need and timing of shunting surgery. MATERIAL AND METHODS: We present and analyze the data of the largest individual series of patients of all age groups operated on for IMTs of the spinal cord: 541 patients; 586 operations; age from 2 months to 72 years...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28914723/inducing-somatic-symptoms-in-functional-syndrome-patients-effects-of-manipulating-state-negative-affect
#6
Maaike Van Den Houte, Katleen Bogaerts, Ilse Van Diest, Jozef De Bie, Philippe Persoons, Lukas Van Oudenhove, Omer Van den Bergh
OBJECTIVE: Induction of negative affective states can enhance bodily symptoms in high habitual symptom reporters among healthy persons, and in patients with irritable bowel syndrome. The aim of this study was to replicate this effect in patients with fibromyalgia and chronic fatigue syndrome and to investigate the role of moderators, focusing on alexithymia, negative affectivity (NA) and absorption. METHODS: Patients with fibromyalgia and/or chronic fatigue syndrome (N=81) and healthy controls (HC, N=41) viewed series of neutral, positive and negative affective pictures...
September 13, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28913928/a-new-complementary-approach-for-oral-health-and-diabetes-management-health-coaching
#7
Ayse Basak Cinar, Ruth Freeman, Lone Schou
BACKGROUND: Health coaching (HC) is based on 'partnering with clients in a thought-provoking and creative process that inspires them to maximise their personal and professional potential' to adopt healthy lifestyles through 'building awareness and empowerment'. This study's objective is to assess, for the first time to our knowledge, the effectiveness of HC compared with health education (HE) using clinical and subjective measures among type 2 diabetes (DM2) patients in Turkey and Denmark...
September 14, 2017: International Dental Journal
https://www.readbyqxmd.com/read/28913574/the-association-between-the-lymphocyte-monocyte-ratio-and-disease-activity-in-rheumatoid-arthritis
#8
Juping Du, Shuaishuai Chen, Jianfeng Shi, Xiaoli Zhu, Haijian Ying, Ying Zhang, Shiyong Chen, Bo Shen, Jun Li
The lymphocyte-monocyte ratio (LMR) is a systemic inflammatory marker for prediction of disease development, progress, and survival. Recently, a genome-wide association study identified genetic variations in ITGA4 and HLA-DRB1 that affect the LMR levels and were widely believed to be susceptibility genes for autoimmune diseases, including rheumatoid arthritis (RA). However, the role of LMR in RA patients remains unclear. The LMR level and other laboratory data of 66 RA patients, 163 osteoarthritis (OA) patients, and 131 healthy controls (HC) were compared using binary logistic regression...
September 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28912625/cognitive-impairment-in-relapsing-remitting-multiple-sclerosis-patients-with-very-mild-clinical-disability
#9
S Migliore, A Ghazaryan, I Simonelli, P Pasqualetti, F Squitieri, G Curcio, D Landi, M G Palmieri, F Moffa, M M Filippi, F Vernieri
Cognitive dysfunction affects 40-65% of multiple sclerosis (MS) patients and can occur in the early stages of the disease. This study aimed to explore cognitive functions by means of the Italian version of the minimal assessment of cognitive function in MS (MACFIMS) in relapsing-remitting MS (RRMS) patients with very mild clinical disability to identify the primarily involved cognitive functions. Ninety-two consecutive RRMS patients with Expanded Disability Status Scale (EDSS) scores ≤ 2.5 and forty-two healthy controls (HC) were investigated...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28912620/hormonal-contraception-and-the-development-of-autoimmunity-a-review-of-the-literature
#10
William V Williams
Estrogens and progestins are known to have profound effects on the immune system and may modulate the susceptibility to autoimmune diseases. A comprehensive literature search was carried out using PubMed for any of 153 autoimmune disease terms and the terms contraception, contraceptive, or their chemical components with limits of Humans + Title or Abstract. Over 1,800 titles were returned and scanned, 352 papers retrieved and reviewed in depth and an additional 70 papers retrieved from the bibliographies. Based on this review, substantial evidence exists linking the use of combined oral contraceptives to a lower incidence of hyperthyroidism, an increase in multiple sclerosis, ulcerative colitis, Crohn's disease, Systemic Lupus Erythematosus, and interstitial cystitis...
August 2017: Linacre Quarterly
https://www.readbyqxmd.com/read/28912043/abnormal-segments-of-right-uncinate-fasciculus-and-left-anterior-thalamic-radiation-in-major-and-bipolar-depression
#11
Feng Deng, Ying Wang, Huiyuan Huang, Meiqi Niu, Shuming Zhong, Ling Zhao, Zhangzhang Qi, Xiaoyan Wu, Yao Sun, Chen Niu, Yuan He, Li Huang, Ruiwang Huang
Differential brain structural abnormalities between bipolar disorder (BD) and major depressive disorder (MDD) may reflect different pathological mechanisms underlying these two brain disorders. However, few studies have directly compared the brain structural properties, especially in white matter (WM) tracts, between BD and MDD. Using automated fiber-tract quantification (AFQ), we utilized diffusion tensor images (DTI) from 67 unmedicated depressed patients, including 31 BD and 36 MDD, and 45 healthy controls (HC) to create fractional anisotropy (FA) tract profiles along 20 major WM tracts...
September 11, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28911257/fatigue-in-multiple-sclerosis-the-contribution-of-resting-state-functional-connectivity-reorganization
#12
Alvino Bisecco, Federica Di Nardo, Renato Docimo, Giuseppina Caiazzo, Alessandro d'Ambrosio, Simona Bonavita, Rocco Capuano, Leonardo Sinisi, Mario Cirillo, Fabrizio Esposito, Gioacchino Tedeschi, Antonio Gallo
OBJECTIVES: To investigate resting-state functional connectivity (RS-FC) of the default-mode network (DMN) and of sensorimotor network (SMN) network in relapsing remitting (RR) multiple sclerosis (MS) patients with fatigue (F) and without fatigue(NF). METHODS: In all, 59 RRMS patients and 29 healthy controls (HC) underwent magnetic resonance imaging (MRI) protocol including resting-state fMRI (RS-fMRI). Functional connectivity of the DMN and SMN was evaluated by independent component analysis (ICA)...
September 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28911138/resetting-the-abnormal-circadian-cortisol-rhythm-in-adrenal-incidentaloma-patients-with-mild-autonomous-cortisol-secretion
#13
Miguel Debono, Robert F Harrison, Rita Chadarevian, Carole Gueroult, Jean-Louis Abitbol, John Newell-Price
Context: Adrenal incidentalomas (AIs) are found commonly on axial imaging. Around 30% exhibit autonomous cortisol secretion (ACS) associated with increased cardiovascular events and death. Objective: We hypothesized that AI/ACS patients have an abnormal cortisol rhythm that could be reversed by use of carefully timed short-acting cortisol synthesis blockade, with improvement in cardiovascular disease markers. Design, Setting, and Participants: In a phase 1/2a, prospective study (Eudract no...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28910775/classification-of-schizophrenia-based-on-individual-hierarchical-brain-networks-constructed-from-structural-mri-images
#14
Jin Liu, Min Li, Yi Pan, Fang-Xiang Wu, Xiaogang Chen, Jianxin Wang
With structural magnetic resonance imaging (MRI) images, conventional methods for the classification of schizophrenia (SCZ) and healthy control (HC) extract cortical thickness independently at different regions of interest (ROIs) without considering the correlation between these regions. In this study we proposed an improved method for the classification of SCZ and HC based on individual hierarchical brain networks constructed from structural MRI images. Our method involves constructing individual hierarchical networks where each node and each edge in these networks represents a ROI and the correlation between a pair of ROIs, respectively...
September 11, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28910390/identify-changes-of-brain-regional-homogeneity-in-early-and-later-adult-onset-patients-with-first-episode-depression-using-resting-state-fmri
#15
Zonglin Shen, Linling Jiang, Shuran Yang, Jing Ye, Nan Dai, Xiaoyan Liu, Na Li, Jin Lu, Fang Liu, Yi Lu, Xuejin Sun, Yuqi Cheng, Xiufeng Xu
OBJECTIVE: Previous work exhibited different brain grey matter volume (GMV) changes between patients with early adult onset depression (EOD, age 18-29) and later adult onset depression (LOD, age 30-44) by using 30-year-old as the cut-off age. To identify whether regional homogeneity (ReHo) changes are also different between EOD and LOD by using same cut-off age, we used resting-state functional magnetic resonance imaging (fMRI) to detect the abnormal ReHo between patients with EOD and LOD in the present study...
2017: PloS One
https://www.readbyqxmd.com/read/28910266/therapeutic-effect-and-mechanism-of-action-of-abnormal-savda-munziq-in-development-of-degenerative-atherosclerotic-aortic-valve-disease
#16
Aisikaer Shabiti, Aili Aibibula, Aikeremu Tuerxun, Halmurat Wufuer
BACKGROUND The aim of this study was to investigate the therapeutic effect of abnormal Savda Munziq (ASMq) on the development of degenerative atherosclerotic aortic valve disease and its underlying mechanisms. MATERIAL AND METHODS We randomly divided 80 rabbits into 4 groups: a normal control group (group N, n=20); a high-fat diet group (group HC, n=20); a high-fat diet and Atorvastatin calcium intervention group (group AI, n=20); and a high-fat diet and ASMq intervention group (group MI, n=20). For evaluation of blood lipid profiles, blood samples were collected at week 0 and at the end of week 8...
September 14, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28906586/equivalent-linear-change-in-cognition-between-individuals-with-bipolar-disorder-and-healthy-controls-over-5%C3%A2-years
#17
Kelly A Ryan, Shervin Assari, Kaley Angers, David F Marshall, Kristin Hinrichs, Rebecca Easter, Pallavi Babu, Bethany D Pester, Scott A Langenecker, Melvin G McInnis
OBJECTIVES: Cognitive dysfunction is a key feature of bipolar disorder (BD). However, not much is known about its temporal stability, as some studies have demonstrated a neurodegenerative model in BD while others have shown no change in cognitive functioning over time. Building upon our prior work, which examined the natural course of executive functioning, the current study aimed to investigate the natural course of memory, emotion processing, and fine motor dexterity over a 5-year period in BD and healthy control (HC) samples...
September 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28906356/shared-polymorphisms-and-modifiable-behavior-factors-for-myocardial-infarction-and-high-cholesterol-in-a-retrospective-population-study
#18
Yulan Liang, Arpad Kelemen
Genetic and environmental (behavior, clinical, and demographic) factors are associated with increased risks of both myocardial infarction (MI) and high cholesterol (HC). It is known that HC is major risk factor that may cause MI. However, whether there are common single nucleotide polymorphism (SNPs) associated with both MI and HC is not firmly established, and whether there are modulate and modified effects (interactions of genetic and known environmental factors) on either HC or MI, and whether these joint effects improve the predictions of MI, is understudied...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28905209/expression-differences-of-genes-in-the-pi3k-akt-wnt-b-catenin-shh-notch-and-mapk-signaling-pathways-in-cd34-hematopoietic-cells-obtained-from-chronic-phase-patients-with-chronic-myeloid-leukemia-and-from-healthy-controls
#19
R de Cássia Viu Carrara, A M Fontes, K J Abraham, M D Orellana, S K Haddad, P V B Palma, R A Panepucci, M A Zago, D T Covas
PURPOSE: The fusion gene BRC-ABL has an important role to the progression of chronic myeloid leukemia (CML) and several signaling pathways have been characterized as responsible for the terminal blastic phase (BP). However, the initial phase, the chronic phase (CP), is long lasting and there is much yet to be understood about the critical role of BRC-ABL in this phase. This study aims to evaluate transcriptional deregulation in CD34+ hematopoietic cells (CD34+ cells) from patients with untreated newly diagnosed CML compared with CD34+HC from healthy controls...
September 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28904371/acute-interaction-between-hydrocortisone-and-insulin-alters-the-plasma-metabolome-in-humans
#20
Mohammad A Alwashih, Roland H Stimson, Ruth Andrew, Brian R Walker, David G Watson
With the aim of identifying biomarkers of glucocorticoid action and their relationship with biomarkers of insulin action, metabolomic profiling was carried out in plasma samples from twenty healthy men who were administered either a low or medium dose insulin infusion (n = 10 each group). In addition, all subjects were given metyrapone (to inhibit adrenal cortisol secretion) + /- hydrocortisone (HC) in a randomised crossover design to produce low, medium and high glucocorticoid levels. The clearest effects of insulin were to reduce plasma levels of the branched chain amino acids (BCAs) leucine/isoleucine and their deaminated metabolites, and lowered free fatty acids and acylcarnitines...
September 13, 2017: Scientific Reports
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