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https://www.readbyqxmd.com/read/28346551/infrared-spectra-of-hscs-c-hscs-and-hcs2-produced-on-electron-bombardment-of-cs2-in-solid-para-hydrogen
#1
Masashi Tsuge, Yuan-Pern Lee
We report infrared (IR) spectra of HSCS(+), c-HSCS, HCS2(-), and other species produced on electron bombardment of a mixture of CS2 and para-hydrogen (p-H2) during deposition at 3.2 K. After maintenance of the deposited matrix in darkness for 12 h, the intensities of the absorption lines of HSCS(+) at 2477.2 (ν1), 1525.6 (ν2), and 919.6 cm(-1) (ν3) decreased through neutralization of HSCS(+) with trapped electrons. During this period, the intensities of the lines of HCS2(-) at 2875.7 (ν1), 1249.9 (ν5), 1003...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28346482/24s-hydroxycholesterol-and-25-hydroxycholesterol-differentially-impact-hippocampal-neuronal-survival-following-oxygen-glucose-deprivation
#2
Min-Yu Sun, Amanda Taylor, Charles F Zorumski, Steven Mennerick
N-methyl-D-aspartate receptors (NMDARs), a major subtype of glutamate receptor mediating excitatory transmission throughout the CNS, participate in ischemia-induced neuronal death. Unfortunately, undesired side effects have limited the strategy of inhibiting/blocking NMDARs as therapy. Targeting endogenous positive allosteric modulators of NMDAR function may offer a strategy with fewer downsides. Here, we explored whether 24S-hydroxycholesterol (24S-HC), an endogenous positive NMDAR modulator characterized recently by our group, participates in NMDAR-mediated excitotoxicity following oxygen-glucose deprivation (OGD) in primary neuron cultures...
2017: PloS One
https://www.readbyqxmd.com/read/28345349/a-self-assembled-ratiometric-polymeric-nanoprobe-for-highly-selective-fluorescence-detection-of-hydrogen-peroxide
#3
Chongchong Feng, Fengyang Wang, Yijing Dang, Zhiai Xu, Haijun Yu, Wen Zhang
In this study, a dual-emission fluorescence resonance energy transfer (FRET) polymeric nanoprobe by single-wavelength excitation was developed for sensitive and selective hydrogen peroxide (H2O2) detection. Polymeric nanoprobe was prepared by simple self-assembly of functional lipopolymers, which were 4-carboxy-3-fluorophenylboronic acid (FPBA)-modified DSPE-PEG (DSPE-PEG-FPBA) and 7-hydroxycoumarin (HC)-conjugated DSPE-PEG (DSPE-PEG-HC). Subsequent binding of alizarin red S (ARS) to FPBA endowed the nanoprobe with a new fluorescence emission peak at around 600 nm...
March 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28345215/temporal-discounting-and-the-tendency-to-delay-gratification-across-the-eating-disorder-spectrum
#4
Savani Bartholdy, Samantha Rennalls, Hollie Danby, Claire Jacques, Iain C Campbell, Ulrike Schmidt, Owen G O'Daly
Bulimia nervosa (BN) and binge eating disorder (BED) have been associated with poorer reward-related inhibitory control, reflected by a reduced tendency to delay gratification. The opposite has been reported in anorexia nervosa (AN), but differences have not been directly compared across eating disorders (EDs). This study investigated self-reported (Delaying Gratification Inventory) and task-based (temporal discounting) inhibitory control in 66 women with an ED and 28 healthy controls (HCs). Poorer task-based inhibitory control was observed in the BN compared with the AN group and poorer self-reported inhibitory control in the BN and in the BED groups compared with the AN and the HC groups, suggesting that reward-related inhibitory control varies across EDs...
March 27, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28344758/no-evidence-of-early-head-circumference-enlargements-in-children-later-diagnosed-with-autism-in-israel
#5
Ilan Dinstein, Shlomi Haar, Shir Atsmon, Hen Schtaerman
BACKGROUND: Large controversy exists regarding the potential existence and clinical significance of larger brain volumes in toddlers who later develop autism. Assessing this relationship is important for determining the clinical utility of early head circumference (HC) measures and for assessing the validity of the early overgrowth hypothesis of autism, which suggests that early accelerated brain development may be a hallmark of the disorder. METHODS: We performed a retrospective comparison of HC, height, and weight measurements between 66 toddlers who were later diagnosed with autism and 66 matched controls...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28344571/translation-initiation-factor-eif4e-and-eifiso4e-are-both-required-for-peanut-stripe-virus-infection-in-peanut-arachis-hypogaea-l
#6
Manlin Xu, Hongfeng Xie, Juxiang Wu, Lianhui Xie, Jinguang Yang, Yucheng Chi
Peanut stripe virus (PStV) belongs to the genus Potyvirus and is the most important viral pathogen of cultivated peanut (Arachis hypogaea L.). The eukaryotic translation initiation factor, eIF4E, and its isoform, eIF(iso)4E, play key roles during virus infection in plants, particularly Potyvirus. In the present study, we cloned the eIF4E and eIF(iso)4E homologs in peanut and named these as PeaeIF4E and PeaeIF(iso)4E, respectively. Quantitative real-time PCR (qRT-PCR) analysis showed that these two genes were expressed during all growth periods and in all peanut organs, but were especially abundant in young leaves and roots...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28343771/characterization-of-human-monoclonal-antibodies-that-neutralize-multiple-poliovirus-serotypes
#7
Rama Devudu Puligedda, Diana Kouiavskaia, Fetweh H Al-Saleem, Chandana Devi Kattala, Usman Nabi, Hamid Yaqoob, V Sandeep Bhagavathula, Rashmi Sharma, Konstantin Chumakov, Scott K Dessain
Following the eradication of wild poliovirus (PV), achieving and maintaining a polio-free status will require eliminating potentially pathogenic PV strains derived from the oral attenuated vaccine. For this purpose, a combination of non-cross-resistant drugs, such as small molecules and neutralizing monoclonal antibodies (mAbs), may be ideal. We previously isolated chimpanzee and human mAbs capable of neutralizing multiple PV types (cross-neutralization). Here, we describe three additional human mAbs that neutralize types 1 and 2 PV and one mAb that neutralizes all three types...
March 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28343215/a-study-of-biological-rhythm-disturbances-in-polish-remitted-bipolar-patients-using-the-brian-csm-and-swpaq-scales
#8
Ewa Dopierala, Adrian Chrobak, Flavio Kapczinski, Michał Michalak, Anna Tereszko, Ewa Ferensztajn-Rochowiak, Dominika Dudek, Jan Jaracz, Marcin Siwek, Janusz K Rybakowski
BACKGROUND/AIMS: The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) is a novel tool allowing for a complex assessment of biological rhythms. We compared patients with bipolar disorder (BD) and healthy control subjects (HC) using the Polish version of the BRIAN scale. METHOD: Fifty-four remitted BD patients (17 males and 37 females aged 52 ± 13 years) and 54 healthy control subjects (25 males and 29 females aged 42 ± 14 years) were studied...
March 25, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28342644/steeper-slope-of-age-related-changes-in-white-matter-microstructure-and-processing-speed-in-bipolar-disorder
#9
Sheena I Dev, Tanya T Nguyen, Benjamin S McKenna, Ashley N Sutherland, Hauke Bartsch, Rebecca J Theilmann, Lisa T Eyler
OBJECTIVES: Bipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). Few studies, however, have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy counterpart (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging...
February 16, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28341378/pilot-scale-intensification-of-rubber-seed-hevea-brasiliensis-oil-via-chemical-interesterification-using-hydrodynamic-cavitation-technology
#10
Awais Bokhari, Suzana Yusup, Lai Fatt Chuah, Jiří Jaromír Klemeš, Saira Asif, Basit Ali, Majid Majeed Akbar, Ruzaimah Nik M Kamil
Chemical interesterification of rubber seed oil has been investigated for four different designed orifice devices in a pilot scale hydrodynamic cavitation (HC) system. Upstream pressure within 1-3.5bar induced cavities to intensify the process. An optimal orifice plate geometry was considered as plate with 1mm dia hole having 21 holes at 3bar inlet pressure. The optimisation results of interesterification were revealed by response surface methodology; methyl acetate to oil molar ratio of 14:1, catalyst amount of 0...
March 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28340261/effect-of-a-high-concentrate-diet-on-milk-components-and-mammary-health-in-holstein-dairy-cows
#11
Z L Xie, J Zhang, D M Zhang, J F Li, Y H Lin
In order to evaluate the milk yield, milk quality, and health of dairy cows fed a high-concentrate (HC) diet, eight lactating Holstein dairy cattle were randomly assigned to HC or low-concentrate (LC) diet groups and fed for 50 days, and the auto-control studying before and after treatment with the two diets was used. During the experiment, plasma and milk samples were collected and measured. With regard to milk component, HC feeding led to higher milk production (P < 0.05), but significantly lower milk protein percentage (P < 0...
March 22, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28338914/impact-of-decentralisation-of-antiretroviral-therapy-services-on-hiv-testing-and-care-at-a-population-level-in-agago-district-in-rural-northern-uganda-results-from-the-lablite-population-surveys
#12
George Abongomera, Sylvia Kiwuwa-Muyingo, Paul Revill, Levison Chiwaula, Travor Mabugu, Andrew N Phillips, Elly Katabira, Adrienne K Chan, Charles Gilks, Victor Musiime, James Hakim, Cissy Kityo, Robert Colebunders, Diana M Gibb, Janet Seeley, Deborah Ford
Background: We conducted unlinked cross-sectional population-based surveys in Northern Uganda before and after antiretroviral therapy (ART) provision (including Option B+ [lifelong ART for pregnant/breast-feeding women]) at a local primary care facility (Lira Kato Health Centre [HC]). Prior to decentralisation, people travelled 56-76 km round-trip for ART; we aimed to evaluate changes in uptake of HIV-testing, ART coverage and access to ART following decentralisation. Methods: A total of 2124 adults in 1351 households in two parishes closest to Lira Kato HC were interviewed using questionnaires between March and April 2013 and 2123 adults in 1229 households between January and March 2015...
March 10, 2017: International Health
https://www.readbyqxmd.com/read/28338779/telomere-length-and-ccl11-levels-are-associated-with-gray-matter-volume-and-episodic-memory-performance-in-schizophrenia-evidence-of-pathological-accelerated-aging
#13
Leticia Sanguinetti Czepielewski, Raffael Massuda, Bruna Panizzutti, Lucas Kich Grun, Florencia María Barbé-Tuana, Antonio Lucio Teixeira, Deanna M Barch, Clarissa S Gama
Schizophrenia (SZ) is associated with increased somatic morbidity and mortality, in addition to cognitive impairments similar to those seen in normal aging, which may suggest that pathological accelerated aging occurs in SZ. Therefore, we aim to evaluate the relationships of age, telomere length (TL), and CCL11 (aging and inflammatory biomarkers, respectively), gray matter (GM) volume and episodic memory performance in individuals with SZ compared to healthy controls (HC). One hundred twelve participants (48 SZ and 64 HC) underwent clinical and memory assessments, structural MRI, and had their peripheral blood drawn for biomarkers analysis...
February 22, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28338608/impact-of-high-carbohydrate-diet-on-metabolic-parameters-in-patients-with-type-2-diabetes
#14
REVIEW
Chan-Hee Jung, Kyung Mook Choi
In patients with type 2 diabetes mellitus (T2DM), whether dietary carbohydrates have beneficial or detrimental effects on cardiometabolic risk factors has drawn attention. Although a high-carbohydrate (HC) diet and a low-carbohydrate (LC) diet have gained popularity for several decades, there is scarce review focusing on the effects of HC diet on glucose, lipids and body weight in patients with T2DM. In this review, we examined recently-published literature on the effects of HC diets on metabolic parameters in T2DM...
March 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28338424/monocytes-seeded-on-engineered-hypertrophic-cartilage-do-not-enhance-endochondral-ossification-capacity
#15
Atanas Todorov, Celeste Scotti, Andrea Barbero, Arnaud Scherberich, Adam Papadimitropoulos, Ivan Martin
Engineered hypertrophic cartilage (HC) represents an attractive bone substitute material, capable to induce bone formation by endochondral ossification. Since bone formation by HC depends on factors released from the extracellular matrix, in this study, we hypothesized that HC seeding with monocytes committed to osteoclastogenesis could enhance its remodeling, improve chemotaxis of skeletal and vascular cells, and consequently enhance bone formation. This would be particularly relevant for devitalized HC, which currently exhibits only limited osteoinductivity...
March 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28338186/increase-in-g-protein-coupled-receptor-autoantibodies-with-decline-of-cardiac-function-in-hypercholesterolemic-rats
#16
Y Li, J Tian, X-R Ma, R-T Li, S-L Zhang, P-L Wang, X-C Yin, J-W Bian, J-H Lei, H-R Liu
OBJECTIVE: This study aimed to explore the effects of diet-induced hypercholesterolemia (HC) on the production of G protein-coupled receptor autoantibodies and to elucidate the potential mechanisms involved. MATERIALS AND METHODS: Male Wistar rats were fed a normal or high-cholesterol diet for 8 weeks. Cardiac function, autoantibodies against G protein-coupled receptors, the beat frequency of neonatal cardiomyocytes, the CD4+/CD8+ T-lymphocyte ratio and lymph leukocyte counts in the spleen were determined...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28337659/a20-in-multiple-sclerosis-and-parkinson-s-disease-clue-to-a-common-dysregulation-of-anti-inflammatory-pathways
#17
Simona Perga, Serena Martire, Francesca Montarolo, Nicole D Navone, Andrea Calvo, Giuseppe Fuda, Alberto Marchet, Daniela Leotta, Adriano Chiò, Antonio Bertolotto
Chronic inflammation significantly contributes to the pathogenesis of several neurodegenerative disorders. In physiological conditions, a chronic inflammatory state is prevented through the termination of the acute inflammatory response once the triggering insult is eliminated. Several mechanisms regulate the resolution of inflammation. Among these, a potent inhibitor of the pro-inflammatory NF-kB signaling known as A20 has emerged as a key player. Recent studies have shown reduced blood levels of A20 in the patients of diverse chronic inflammatory diseases...
March 23, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28336779/validation-of-the-semi-quantitative-static-suvr-method-for-18-f-av45-pet-by-pharmacokinetic-modeling-with-an-arterial-input-function
#18
Julie Ottoy, Jeroen Verhaeghe, Ellis Niemantsverdriet, Leonie Wyffels, Charisse Somers, Ellen De Roeck, Hanne Struyfs, Femke Soetewey, Steven Deleye, Tobi Van den Bossche, Sara Van Mossevelde, Sarah Ceyssens, Jan Versijpt, Sigrid Stroobants, Sebastiaan Engelborghs, Steven Staelens
Increased brain uptake of [(18)F]-AV45 visualized by PET is a key biomarker for Alzheimer's disease (AD). The standardized uptake value ratio (SUVR) is widely used for quantification, but is subject to variability based on choice of reference region and changes in cerebral blood flow. Here we validate the SUVR method against the gold standard volume of distribution (VT) to assess cross-sectional differences in plaque load. Methods: Dynamic 60-min [(18)F]-AV45 (291 ± 67 MBq) and 1-min [(15)O]-H2O (370 MBq) scans were obtained in 35 age-matched elderly subjects, including 10 probable AD dementia, 15 amnestic mild cognitive impairment (aMCI) and 10 cognitively healthy controls (HC)...
March 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28334676/manual-motor-speed-dysfunction-as-a-neurocognitive-endophenotype-in-euthymic-bipolar-disorder-patients-and-their-healthy-relatives-evidence-from-a-5-year-follow-up-study
#19
P Correa-Ghisays, V Balanzá-Martínez, G Selva-Vera, J Vila-Francés, E Soria-Olivas, J Vivas-Lalinde, C San Martín, A M Borrás, R Ayesa-Arriola, J Sanchez-Moreno, J Sánchez-Ort, B Crespo-Facorro, E Vieta, R Tabarés-Seisdedos
BACKGROUND: Few studies have examined Manual Motor Speed (MMS) in bipolar disorder (BD). The aim of this longitudinal, family study was to explore whether dysfunctional MMS represents a neurocognitive endophenotype of BD. METHODS: A sample of 291 subjects, including 131 BD patients, 77 healthy first-degree relatives (BD-Rel), and 83 genetically-unrelated healthy controls (HC), was assessed with the Finger-Tapping Test (FTT) on three occasions over a 5-year period...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28334378/patterns-of-false-memory-in-patients-with-huntington-s-disease
#20
I-Wen Chen, Chiung-Mei Chen, Yih-Ru Wu, Mau-Sun Hua
Objective: Increased false memory recognition in patients with Huntington's disease (HD) has been widely reported; however, the underlying memory constructive processes remain unclear. The present study explored gist memory, item-specific memory, and monitoring ability in patients with HD. Method: Twenty-five patients (including 13 patients with mild HD and 12 patients with moderate-to-severe HD) and 30 healthy comparison participants (HC) were recruited. We used the Deese-Roediger-McDermott (DRM) paradigm to investigate participants' false recognition patterns, along with neuropsychological tests to assess general cognitive function...
March 17, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
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