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Bone Marrow Concentrate and Osteoarthritis

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https://www.readbyqxmd.com/read/27882169/efficacy-of-mesenchymal-stem-cells-in-treating-patients-with-osteoarthritis-of-the-knee-a-meta-analysis
#1
Gang-Hua Cui, Yang Yang Wang, Chang-Jun Li, Chen-Hui Shi, Wei-Shan Wang
To assess the clinical efficacy and safety of mesenchymal stem cell (MSC) treatment for osteoarthritis of the knee (KOA), a systematic electronic literature search was performed on PubMed, EMBASE and Web of Science. Studies published in English from the earliest record to December 2014 were searched using the following keywords: Cartilage defect, cartilage repair, osteoarthritis, KOA, stem cells, MSCs, bone marrow concentrate (BMC), adipose-derived mesenchymal stem cells, synovial-derived mesenchymal stem cells and peripheral blood-derived mesenchymal stem cells...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27813021/bone-marrow-aspirate-concentrate-for-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-of-outcomes
#2
REVIEW
Jorge Chahla, Mark E Cinque, Jason M Shon, Daniel J Liechti, Lauren M Matheny, Robert F LaPrade, Thomas O Clanton
BACKGROUND: The goal of this perform a systematic review on the outcomes of bone marrow aspirate concentrate (BMAC) for the treatment of chondral defects and osteoarthritis (OA) of the talus. RESULTS: The systematic search performed identified 47 studies after duplicates were removed. After inclusion criteria were applied four studies were considered for insightful analysis for the treatment of focal chondral defects in the foot and ankle with the use of BMAC. Three studies were retrospective and one study was prospective in nature...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27575050/autologous-bone-marrow-derived-mesenchymal-stem-cells-modulate-molecular-markers-of-inflammation-in-dogs-with-cruciate-ligament-rupture
#3
Peter Muir, Eric C Hans, Molly Racette, Nicola Volstad, Susannah J Sample, Caitlin Heaton, Gerianne Holzman, Susan L Schaefer, Debra D Bloom, Jason A Bleedorn, Zhengling Hao, Ermias Amene, M Suresh, Peiman Hematti
Mid-substance rupture of the canine cranial cruciate ligament rupture (CR) and associated stifle osteoarthritis (OA) is an important veterinary health problem. CR causes stifle joint instability and contralateral CR often develops. The dog is an important model for human anterior cruciate ligament (ACL) rupture, where rupture of graft repair or the contralateral ACL is also common. This suggests that both genetic and environmental factors may increase ligament rupture risk. We investigated use of bone marrow-derived mesenchymal stem cells (BM-MSCs) to reduce systemic and stifle joint inflammatory responses in dogs with CR...
2016: PloS One
https://www.readbyqxmd.com/read/27566242/a-prospective-single-blind-placebo-controlled-trial-of-bone-marrow-aspirate-concentrate-for-knee-osteoarthritis
#4
Shane A Shapiro, Shari E Kazmerchak, Michael G Heckman, Abba C Zubair, Mary I O'Connor
BACKGROUND: Bone marrow aspirate concentrate (BMAC) is increasingly used as a regenerative therapy for musculoskeletal pathological conditions despite limited evidence-based support. HYPOTHESIS: BMAC will prove feasible, safe, and efficacious for the treatment of pain due to mild to moderate degenerative joint disease of the knee. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2. METHODS: In this prospective, single-blind, placebo-controlled trial, 25 patients with bilateral knee pain from bilateral osteoarthritis were randomized to receive BMAC into one knee and saline placebo into the other...
August 26, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27527808/intra-articular-bone-marrow-concentrate-injection-protocol-short-term-efficacy-in-osteoarthritis
#5
Steven Sampson, Jay Smith, Hunter Vincent, Danielle Aufiero, Mona Zall, Angie Botto-van-Bemden
AIM: Evaluate intra-articular injection of bone marrow concentrate (BMC), followed by platelet-rich plasma (PRP) injection at 8 weeks follow-up in moderate/severe osteoarthritis. DESIGN: Single center, retrospective Case Series (n = 125). METHODS: Bone marrow was aspirated/concentrated using a standardized technique. Patients received a single intra-articular injection of BMC, with follow-up injection of PRP at 8 weeks. RESULTS: Median absolute pain reduction in all joints was five points (71...
September 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27515308/identification-and-validation-of-multiple-cell-surface-markers-of-clinical-grade-adipose-derived-mesenchymal-stromal-cells-as-novel-release-criteria-for-good-manufacturing-practice-compliant-production
#6
Emily T Camilleri, Michael P Gustafson, Amel Dudakovic, Scott M Riester, Catalina Galeano Garces, Christopher R Paradise, Hideki Takai, Marcel Karperien, Simon Cool, Hee-Jeong Im Sampen, A Noelle Larson, Wenchun Qu, Jay Smith, Allan B Dietz, Andre J van Wijnen
BACKGROUND: Clinical translation of mesenchymal stromal cells (MSCs) necessitates basic characterization of the cell product since variability in biological source and processing of MSCs may impact therapeutic outcomes. Although expression of classical cell surface markers (e.g., CD90, CD73, CD105, and CD44) is used to define MSCs, identification of functionally relevant cell surface markers would provide more robust release criteria and options for quality control. In addition, cell surface expression may distinguish between MSCs from different sources, including bone marrow-derived MSCs and clinical-grade adipose-derived MSCs (AMSCs) grown in human platelet lysate (hPL)...
August 11, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27474386/one-stage-cartilage-repair-using-a-hyaluronic-acid-based-scaffold-with-activated-bone-marrow-derived-mesenchymal-stem-cells-compared-with-microfracture-five-year-follow-up
#7
Alberto Gobbi, Graeme P Whyte
BACKGROUND: Articular cartilage injury is frequently encountered, yet treatment options capable of providing durable cartilage repair are limited. PURPOSE: To investigate the medium-term clinical outcomes of cartilage repair using a 1-stage technique of a hyaluronic acid-based scaffold with activated bone marrow aspirate concentrate (HA-BMAC) and compare results with those of microfracture. A secondary aim of this study was to identify specific patient demographic factors and cartilage lesion characteristics that are associated with superior outcomes...
July 29, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27359284/biological-therapies-for-cartilage-lesions-in-the-hip-a-new-horizon
#8
Jorge Chahla, Robert F LaPrade, Rodrigo Mardones, Johnny Huard, Marc J Philippon, Shane Nho, Omer Mei-Dan, Cecilia Pascual-Garrido
Treatment of hip cartilage disease is challenging, and there is no clear algorithm to address this entity. Biomarkers are arising as promising diagnostic tools because they could play a role in the early assessment of the prearthritic joint and as a prognostic factor before and after treatment. The potential effect of biomarkers may be used to categorize individuals at risk of evolving to severe osteoarthritis, to develop new measures for clinical progression of the disease, and to develop new treatment options for the prevention of osteoarthritis progression...
July 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/27285121/intraosseous-delivery-of-bone-morphogenic-protein-2-using-a-self-assembling-peptide-hydrogel
#9
Matthew C Phipps, Felipe Monte, Manav Mehta, Harry K W Kim
Osteonecrosis of the femoral head (ONFH) is a debilitating hip disorder, which often produces a permanent femoral head deformity and osteoarthritis. The local delivery of biological agents capable of stimulating bone healing offer potential new treatment options for patients with ONFH. Previous studies from our laboratory have shown that a local intraosseous infusion of bone morphogenic protein-2 (BMP-2) was effective in stimulating new bone formation in a piglet model of ischemic ONFH. However, infusion of BMP-2 solution was associated with unwanted dissemination of BMP-2 out of the femoral head and produced heterotopic ossification in the hip capsule...
July 11, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27272202/inflammation-induced-transgene-expression-in-genetically-engineered-equine-mesenchymal-stem-cells
#10
Simone Gabner, Juraj Hlavaty, Karsten Velde, Matthias Renner, Florien Jenner, Monika Egerbacher
BACKGROUND: Osteoarthritis, a chronic and progressive degenerative joint disorder, ranks amongst the top five causes of disability. Given the high incidence, associated socioeconomic costs and the absence of effective disease-modifying therapies of osteoarthritis, cell-based treatments offer a promising new approach. Owing to their paracrine, differentiation and self-renewal abilities, mesenchymal stem cells (MSCs) have great potential for regenerative medicine, which might be further enhanced by targeted gene therapy...
August 2016: Journal of Gene Medicine
https://www.readbyqxmd.com/read/27151837/autologous-bone-marrow-concentrate-in-a-sheep-model-of-osteoarthritis-new-perspectives-for-cartilage-and-meniscus-repair
#11
Giovanna Desando, Gianluca Giavaresi, Carola Cavallo, Isabella Bartolotti, Federica Sartoni, Nicolò Nicoli Aldini, Lucia Martini, Annapaola Parrilli, Erminia Mariani, Milena Fini, Brunella Grigolo
INTRODUCTION: Cell-based therapies are becoming a valuable tool to treat osteoarthritis (OA). This study investigated and compared the regenerative potential of bone marrow concentrate (BMC) and mesenchymal stem cells (MSC), both engineered with Hyaff(®)-11 (HA) for OA treatment in a sheep model. METHODS: OA was induced via unilateral medial meniscectomy. Bone marrow was aspirated from the iliac crest, followed by concentration processes or cell isolation and expansion to obtain BMC and MSC, respectively...
June 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/26798765/concentrated-bone-marrow-aspirate-for-the-treatment-of-chondral-injuries-and-osteoarthritis-of-the-knee-a-systematic-review-of-outcomes
#12
Jorge Chahla, Chase S Dean, Gilbert Moatshe, Cecilia Pascual-Garrido, Raphael Serra Cruz, Robert F LaPrade
BACKGROUND: Bone marrow aspirate concentrate (BMAC) has emerged as a novel treatment for pathology of the knee. Despite containing a limited number of stem cells, BMAC serves as a source of growth factors that are thought to play an important role as a result of their anabolic and anti-inflammatory effects. To our knowledge, there is no systematic review regarding the outcomes of bone marrow aspirate concentrate used for the treatment of chondral defects and osteoarthritis of the knee...
January 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/26629319/caldecrin-a-pancreas-derived-hypocalcemic-factor-regulates-osteoclast-formation-and-function
#13
REVIEW
Mineko Tomomura, Akito Tomomura
Caldecrin was originally isolated from the pancreas as a factor that reduced serum calcium levels. This secreted serine protease has chymotrypsin-like activity and is also known as chymotrypsin C; it belongs to the elastase family. Although intravenous administration of caldecrin decreases the serum calcium concentration even when its protease activity is blocked, this effect does require cleavage of caldecrin's pro-peptide by trypsin, converting it to the mature enzyme. Ectopic intramuscular expression of caldecrin prevented bone resorption in ovariectomized mice...
November 26, 2015: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26385099/a-dose-response-analysis-of-a-specific-bone-marrow-concentrate-treatment-protocol-for-knee-osteoarthritis
#14
Christopher J Centeno, Hasan Al-Sayegh, Jamil Bashir, Shaun Goodyear, Michael D Freeman
BACKGROUND: Prior studies describing the treatment of symptomatic knee osteoarthritis with injections of bone marrow concentrate have provided encouraging results. The relationship between the cellular dose contained within the bone marrow concentrate and efficacy of the treatment, however, is unclear. In the present study we describe clinical outcomes for symptomatic knee osteoarthritis in relation to higher and lower cell concentrations contained within a bone marrow concentrate treatment protocol...
September 18, 2015: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/26143238/combining-concentrated-autologous-bone-marrow-stem-cells-injection-with-core-decompression-improves-outcome-for-patients-with-early-stage-osteonecrosis-of-the-femoral-head-a-comparative-study
#15
RANDOMIZED CONTROLLED TRIAL
Reza Mostafavi Tabatabaee, Sadegh Saberi, Javad Parvizi, Seyed Mohammad Javad Mortazavi, Mahmoud Farzan
The management of early-stage osteonecrosis of the femoral head (ONFH) remains challenging. This study aimed to evaluate the effects of core decompression and concentrated bone marrow implantation on ONFH. The study recruited 28 hips with early ONFH randomly assigned into two groups of core decompression with (group A) and without (group B) bone marrow injection. Patients were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, Visual Analogue Scale (VAS) pain index, and MRI...
September 2015: Journal of Arthroplasty
https://www.readbyqxmd.com/read/26089699/a-prospective-multi-site-registry-study-of-a-specific-protocol-of-autologous-bone-marrow-concentrate-for-the-treatment-of-shoulder-rotator-cuff-tears-and-osteoarthritis
#16
Christopher J Centeno, Hasan Al-Sayegh, Jamil Bashir, Shaun Goodyear, Michael D Freeman
INTRODUCTION: Shoulder pain is a common musculoskeletal complaint in the general population. Bone marrow concentrate (BMC) injections offer promising potential as a minimally invasive approach for treatment of shoulder pain in degenerative disease. In this study, we investigated the clinical outcomes of the BMC injections for treatment of shoulder pain and disability due to osteoarthritis (OA) and rotator cuff tears in a treatment registry population. METHODS: A total of 115 shoulders in 102 patients were treated with autologous BMC injections for symptomatic OA at the glenohumeral joint and/or rotator cuff tears...
2015: Journal of Pain Research
https://www.readbyqxmd.com/read/26069711/matrix-induced-autologous-chondrocyte-implantation-versus-multipotent-stem-cells-for-the-treatment-of-large-patellofemoral-chondral-lesions-a-nonrandomized-prospective-trial
#17
Alberto Gobbi, Sanyam Chaurasia, Georgios Karnatzikos, Norimasa Nakamura
OBJECTIVE: To compare the outcome of matrix-induced autologous chondrocyte implantation (MACI) and bone marrow aspirate concentrate (BMAC)-derived multipotent stem cells (MSCs) implantation in patellofemoral chondral lesions, using the same HYAFF11 scaffold. METHODS: From January 2005 to December 2010, 37 patients with patellofemoral chondral lesions were prospectively followed up, for a minimum of 3 years; 19 of these patients were treated with MACI and 18 with BMAC...
April 2015: Cartilage
https://www.readbyqxmd.com/read/26069587/one-step-cartilage-repair-with-bone-marrow-aspirate-concentrated-cells-and-collagen-matrix-in-full-thickness-knee-cartilage-lesions-results-at-2-year-follow-up
#18
Alberto Gobbi, Georgios Karnatzikos, Celeste Scotti, Vivek Mahajan, Laura Mazzucco, Brunella Grigolo
OBJECTIVE: The purpose of our study was to determine the effectiveness of cartilage repair utilizing 1-step surgery with bone marrow aspirate concentrate (BMAC) and a collagen I/III matrix (Chondro-Gide, Geistlich, Wolhusen, Switzerland). MATERIALS AND METHODS: We prospectively followed up for 2 years 15 patients (mean age, 48 years) who were operated for grade IV cartilage lesions of the knee. Six of the patients had multiple chondral lesions; the average size of the lesions was 9...
July 2011: Cartilage
https://www.readbyqxmd.com/read/25977164/expression-of-genes-involved-in-immune-response-and-in-vitro-immunosuppressive-effect-of-equine-mscs
#19
Ana Rosa Remacha, Laura Barrachina, Samuel Álvarez-Arguedas, Beatriz Ranera, Antonio Romero, Francisco José Vázquez, Pilar Zaragoza, Rosa Yañez, Inmaculada Martín-Burriel, Clementina Rodellar
The immunomodulatory capacities of mesenchymal stem cells (MSCs) have made them the subject of increased clinical interest for tissue regeneration and repair. We have studied the immunomodulatory capacity of equine MSCs derived from bone marrow (BM-MSCs) and adipose tissue (AT-MSCs) in cocultures with allogeneic peripheral blood mononuclear cells (PBMCs). Different isoforms and concentrations of phytohaemaglutinin (PHA) were tested to determine the best stimulation conditions for PBMC proliferation and a proliferation assay was performed for 7 days to determine the optimal day of stimulation of PBMCs...
June 15, 2015: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/25882932/-bone-marrow-mesenchymal-stem-cells-in-sprague-dawley-rat-model-of-osteoarthritis
#20
Y P Cui, Y P Cao, H Liu, X Yang, Z C Meng, R Wang
OBJECTIVE: To investigate the efficacy of single time intra-articular different concentration of allogeneic bone marrow mesenchymal stem cells (BM-MSCs) injection in the treatment of Sprague-Dawley (SD) rat model of osteoarthritis (OA). METHODS: In the study, 32 SD rats were equally randomized into 4 groups: control group, high concentration group (1×10(7)/mL BM-MSCs), low concentration group (5×10(6)/mL BM-MSCs) and high vs. low concentration group. The two knees of each rat were set up to a pair...
April 18, 2015: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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