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Bone Marrow Concentrate and Osteoarthritis

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https://www.readbyqxmd.com/read/29112682/cross-coupling-effects-of-silencing-of-cyclooxygenase-2-cox-2-aggrecanase-1-and-over-expressed-insulin-like-growth-factor-1-igf-1-in-an-osteoarthritis-animal-model
#1
Zhao Zhang, Xiaofei Li, Heng Huang, Guozhong Wang, Zhigang Qu, Haining Zhang
BACKGROUND This study aimed to observe the effect of lentivirus-mediated cyclooxygenase-2 and aggrecanase-1 silencing and insulin-like growth factor-1 overexpression in human bone marrow mesenchymal stem cells after injection into model osteoarthritic knees. MATERIAL AND METHODS Using genetic recombination technique, the genes of cyclooxygenase-2, aggrecanase-1, and insulin-like growth factor-1 were recombined into the lentiviral vectors, and we transfected the human bone marrow stem cells in vitro. The BMSC transfected with lentivirus without genes served as a blank-virus group, and saline was used for another control group...
November 7, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29108480/short-term-homing-of-hyaluronan-primed-cells-therapeutic-implications-for-osteoarthritis-treatment
#2
Giovanna Desando, Isabella Bartolotti, Carola Cavallo, Antonella Schiavinato, Cynthia Secchieri, Elizaveta Kon, Giuseppe Filardo, Maurizio Paro, Brunella Grigolo
The evaluation of key factors modulating cell homing following transplantation can provide new insights in the comprehension of unsolved biological questions about the use of cell therapies for osteoarthritis (OA). The main purpose of this in vivo study was to investigate the biodistribution of an intra-articular (IA) injection of mesenchymal stromal cells (MSCs) and bone marrow concentrate (BMC) in a rabbit OA model, and whether the additional use of sodium hyaluronate (HA) could modulate their migration and promote joint repair...
November 6, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29016185/clinical-outcomes-of-knee-osteoarthritis-treated-with-an-autologous-protein-solution-injection-a-1-year-pilot-double-blinded-randomized-controlled-trial
#3
Elizaveta Kon, Lars Engebretsen, Peter Verdonk, Stefan Nehrer, Giuseppe Filardo
BACKGROUND: Osteoarthritis (OA) is a debilitating disease resulting in substantial pain and functional limitations. A novel blood derivative has been developed to concentrate both growth factors and antagonists of inflammatory cytokines, with promising preliminary findings in terms of safety profile and clinical improvement. PURPOSE: To investigate if one intra-articular injection of autologous protein solution (APS) can reduce pain and improve function in patients affected by knee OA in a multicenter, randomized, double-blind, saline-controlled study...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28993845/-new-experimental-strategies-in-cartilage-surgery
#4
REVIEW
L Rackwitz, J C Reichert, O Pullig, U Nöth
BACKGROUND: Cell and growth factor based strategies bear great potential to support the healing processes in cartilage repair and the therapy of osteoarthritic joints. OBJECTIVES: The following review provides an overview of novel experimental strategies for the therapy of focal cartilage defects and osteoarthritis, with emphasis on cell and growth factor based approaches. MATERIALS AND METHODS: The authors summarize their own data regarding the intraarticular injection of stem cells to treat osteoarthritis of the knee and provide a synopsis of the available literature discussing the most significant publications...
November 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28988340/inefficacy-of-autologous-bone-marrow-concentrate-in-stage-three-osteonecrosis-a-randomized-controlled-double-blind-trial
#5
Jean-Philippe Hauzeur, Viviane De Maertelaer, Etienne Baudoux, Michel Malaise, Yves Beguin, Valérie Gangji
PURPOSE: The fracture stage of non-traumatic osteonecrosis (ON stage 3) of the femoral head (ONFH) has an unfavourable prognosis frequently requiring total hip replacement (THR). The percentage could be lowered after core decompression. In earlier non-fracture ON stages, implantation of autologous bone marrow aspirate concentrate (BMAC) improved the effect of core decompression. The purpose was to evaluate the effect of BMAC in addition to core decompression in stage 3 ONFH. METHODS: A double blind RCT was conducted comparing two groups: core decompression plus saline injection or core decompression plus BMAC implantation...
October 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28831830/biological-treatment-of-the-knee-with-platelet-rich-plasma-or-bone-marrow-aspirate-concentrates
#6
REVIEW
Gilbert Moatshe, Elizabeth R Morris, Mark E Cinque, Cecilia Pascual-Garrido, Jorge Chahla, Lars Engebretsen, Robert F Laprade
- Knee pathologies including focal cartilage injuries, osteoarthritis (OA), and ligament injuries are common. The poor regeneration and healing potential of cartilage has led to the search for other treatment modalities with improved healing capacity. Furthermore, with an increasing elderly population that desires to remain active, the burden of knee pathologies is expected to increase. Increased sports participation and the desire to return to activities faster is also demanding more effective and minimally invasive treatment options...
December 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28660142/clinical-application-of-concentrated-bone-marrow-aspirate-in-orthopaedics-a-systematic-review
#7
Arianna L Gianakos, Li Sun, Jay N Patel, Donald M Adams, Frank A Liporace
AIM: To examine the evidence behind the use of concentrated bone marrow aspirate (cBMA) in cartilage, bone, and tendon repair; establish proof of concept for the use of cBMA in these biologic environments; and provide the level and quality of evidence substantiating the use of cBMA in the clinical setting. METHODS: We conducted a systematic review according to PRISMA guidelines. EMBASE, MEDLINE, and Web of Knowledge databases were screened for the use of cBMA in the repair of cartilage, bone, and tendon repair...
June 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28654811/return-to-running-following-knee-osteochondral-repair-using-an-anti-gravity-treadmill-a-case-report
#8
Karen Hambly, Somruthai Poomsalood, Emma Mundy
BACKGROUND: The purpose of this study was to assess the impact of an anti-gravity treadmill return to running programme on self-efficacy and subjective knee function following knee osteochondral surgery. CASE DESCRIPTION: A 39-year-old otherwise healthy female endurance runner with a left knee femoral cartilage grade 3-4 defect 3 cm(2). The patient underwent single step arthroscopic microfracture with Bone Marrow Aspirate Concentrate. An AlterG(®) anti-gravity treadmill was used to manipulate loading during a graduated phased return to running over 8 weeks...
July 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28616392/catastrophic-complication-following-injection-and-extracorporeal-shock-wave-therapy-of-a-medial-femoral-condyle-subchondral-cystic-lesion-in-a-14-year-old-arabian-mare
#9
Darla K Moser, Mike J Schoonover, Kate M Sippel, Alix M Dieterly, Jerry W Ritchey, Corey R Wall
This report describes fibrous cyst lining injection and extracorporeal shock wave therapy (ESWT) of a medial femoral condyle (MFC) subchondral cystic lesion (SCL) resulting in catastrophic MFC fracture in an Arabian mare. The mare was presented for evaluation of a severe hind limb lameness of approximately 4 months duration. On presentation, a non-weight bearing lameness of the left hind limb with severe effusion and soft tissue swelling of the stifle region was noted. Radiographic evaluation of the stifle revealed a large SCL of the MFC with associated osteoarthritis...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28580265/bone-marrow-aspirate-concentrate-harvesting-and-processing-technique
#10
Jorge Chahla, Sandeep Mannava, Mark E Cinque, Andrew G Geeslin, David Codina, Robert F LaPrade
Bone marrow obtained by iliac crest aspiration is a common source for harvesting mesenchymal stem cells, other progenitor cells, and associated cytokine/growth factors. Recent studies have reported good to excellent outcomes with the use of bone marrow aspirate concentrate (BMAC) for pain relief in the treatment of focal chondral lesions and osteoarthritis of the knee. However, the harvesting and processing technique are crucial to achieve satisfactory results. Several studies have examined outcomes after BMAC injection, with encouraging results, but there is a lack of consensus in terms of the frequency of injection, the amount of BMAC that is injected, and the timing of BMAC injections...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28505164/human-decellularized-bone-scaffolds-from-aged-donors-show-improved-osteoinductive-capacity-compared-to-young-donor-bone
#11
Christopher A Smith, Tim N Board, Paul Rooney, Mark J Eagle, Stephen M Richardson, Judith A Hoyland
To improve the safe use of allograft bone, decellularization techniques may be utilized to produce acellular scaffolds. Such scaffolds should retain their innate biological and biomechanical capacity and support mesenchymal stem cell (MSC) osteogenic differentiation. However, as allograft bone is derived from a wide age-range, this study aimed to determine whether donor age impacts on the ability an osteoinductive, acellular scaffold produced from human bone to promote the osteogenic differentiation of bone marrow MSCs (BM-MSC)...
2017: PloS One
https://www.readbyqxmd.com/read/28409101/microdrilling-surgery-augmented-with-intra-articular-bone-marrow-aspirate-concentrate-platelet-rich-plasma-and-hyaluronic-acid-a-technique-for-cartilage-repair-in-the-knee
#12
Joseph E Broyles, M Adaire O'Brien, M Patrick Stagg
The ideal treatment of large full-thickness chondral lesions in the knee, especially "kissing lesions" and osteoarthritis, has not been determined. Microdrilling surgery augmented with injections of peripheral blood stem cells and hyaluronic acid has been used to treat patients with a wide range of articular cartilage disease including patients with bipolar lesions and joint space narrowing. Excellent results in this difficult patient population have been reported, and second-look biopsy has shown repair tissue very similar to native hyaline cartilage...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28064033/altered-gait-mechanics-and-elevated-serum-pro-inflammatory-cytokines-in-asymptomatic-patients-with-mri-evidence-of-knee-cartilage-loss
#13
S N Edd, J Favre, K Blazek, P Omoumi, J L Asay, T P Andriacchi
OBJECTIVE: To test if sagittal plane gait mechanics parameters and serum inflammation levels differ between healthy asymptomatic subjects and asymptomatic subjects with magnetic resonance imaging (MRI) evidence of cartilage loss. DESIGN: Gait mechanics and resting serum tumor necrosis factor-α (TNFα) concentrations were measured for two groups of asymptomatic subjects recruited for a previous study: Pre-Osteoarthritis (OA) subjects had MRI evidence of partial- or full-thickness knee cartilage loss in at least one compartment (n = 52 (30 female), 1...
June 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28002902/bone-marrow-concentrated-cells-and-stromal-vascular-fraction-cells-injections-for-osteoarthritis-treatment-a-systematic-review
#14
G Vadalà, R Papalia, L La Verde, F Russo, V Denaro, M A Rosa
The aim of this systematic review is to examine current clinical evidences supporting the intraarticular injection of bone marrow concentrate cells (BMC) and adipose-derived stromal vascular fraction cells (SVF) for the treatment of osteoarthritis (OA). The research was performed on PubMed (Medline), EMBASE and Cochrane Library considering the English literature. Only clinical trials have been included. The systematic research identified twelve clinical trials. Articles included in the study, were one of level II, four of level III, six of level IV and one level V...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27882169/efficacy-of-mesenchymal-stem-cells-in-treating-patients-with-osteoarthritis-of-the-knee-a-meta-analysis
#15
Gang-Hua Cui, Yang Yang Wang, Chang-Jun Li, Chen-Hui Shi, Wei-Shan Wang
To assess the clinical efficacy and safety of mesenchymal stem cell (MSC) treatment for osteoarthritis of the knee (KOA), a systematic electronic literature search was performed on PubMed, EMBASE and Web of Science. Studies published in English from the earliest record to December 2014 were searched using the following keywords: Cartilage defect, cartilage repair, osteoarthritis, KOA, stem cells, MSCs, bone marrow concentrate (BMC), adipose-derived mesenchymal stem cells, synovial-derived mesenchymal stem cells and peripheral blood-derived mesenchymal stem cells...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27813021/bone-marrow-aspirate-concentrate-for-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-of-outcomes
#16
REVIEW
Jorge Chahla, Mark E Cinque, Jason M Shon, Daniel J Liechti, Lauren M Matheny, Robert F LaPrade, Thomas O Clanton
BACKGROUND: The goal of this perform a systematic review on the outcomes of bone marrow aspirate concentrate (BMAC) for the treatment of chondral defects and osteoarthritis (OA) of the talus. RESULTS: The systematic search performed identified 47 studies after duplicates were removed. After inclusion criteria were applied four studies were considered for insightful analysis for the treatment of focal chondral defects in the foot and ankle with the use of BMAC. Three studies were retrospective and one study was prospective in nature...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27575050/autologous-bone-marrow-derived-mesenchymal-stem-cells-modulate-molecular-markers-of-inflammation-in-dogs-with-cruciate-ligament-rupture
#17
Peter Muir, Eric C Hans, Molly Racette, Nicola Volstad, Susannah J Sample, Caitlin Heaton, Gerianne Holzman, Susan L Schaefer, Debra D Bloom, Jason A Bleedorn, Zhengling Hao, Ermias Amene, M Suresh, Peiman Hematti
Mid-substance rupture of the canine cranial cruciate ligament rupture (CR) and associated stifle osteoarthritis (OA) is an important veterinary health problem. CR causes stifle joint instability and contralateral CR often develops. The dog is an important model for human anterior cruciate ligament (ACL) rupture, where rupture of graft repair or the contralateral ACL is also common. This suggests that both genetic and environmental factors may increase ligament rupture risk. We investigated use of bone marrow-derived mesenchymal stem cells (BM-MSCs) to reduce systemic and stifle joint inflammatory responses in dogs with CR...
2016: PloS One
https://www.readbyqxmd.com/read/27566242/a-prospective-single-blind-placebo-controlled-trial-of-bone-marrow-aspirate-concentrate-for-knee-osteoarthritis
#18
RANDOMIZED CONTROLLED TRIAL
Shane A Shapiro, Shari E Kazmerchak, Michael G Heckman, Abba C Zubair, Mary I O'Connor
BACKGROUND: Bone marrow aspirate concentrate (BMAC) is increasingly used as a regenerative therapy for musculoskeletal pathological conditions despite limited evidence-based support. HYPOTHESIS: BMAC will prove feasible, safe, and efficacious for the treatment of pain due to mild to moderate degenerative joint disease of the knee. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2. METHODS: In this prospective, single-blind, placebo-controlled trial, 25 patients with bilateral knee pain from bilateral osteoarthritis were randomized to receive BMAC into one knee and saline placebo into the other...
January 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27527808/intra-articular-bone-marrow-concentrate-injection-protocol-short-term-efficacy-in-osteoarthritis
#19
Steven Sampson, Jay Smith, Hunter Vincent, Danielle Aufiero, Mona Zall, Angie Botto-van-Bemden
AIM: Evaluate intra-articular injection of bone marrow concentrate (BMC), followed by platelet-rich plasma (PRP) injection at 8 weeks follow-up in moderate/severe osteoarthritis. DESIGN: Single center, retrospective Case Series (n = 125). METHODS: Bone marrow was aspirated/concentrated using a standardized technique. Patients received a single intra-articular injection of BMC, with follow-up injection of PRP at 8 weeks. RESULTS: Median absolute pain reduction in all joints was five points (71...
September 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27515308/identification-and-validation-of-multiple-cell-surface-markers-of-clinical-grade-adipose-derived-mesenchymal-stromal-cells-as-novel-release-criteria-for-good-manufacturing-practice-compliant-production
#20
Emily T Camilleri, Michael P Gustafson, Amel Dudakovic, Scott M Riester, Catalina Galeano Garces, Christopher R Paradise, Hideki Takai, Marcel Karperien, Simon Cool, Hee-Jeong Im Sampen, A Noelle Larson, Wenchun Qu, Jay Smith, Allan B Dietz, Andre J van Wijnen
BACKGROUND: Clinical translation of mesenchymal stromal cells (MSCs) necessitates basic characterization of the cell product since variability in biological source and processing of MSCs may impact therapeutic outcomes. Although expression of classical cell surface markers (e.g., CD90, CD73, CD105, and CD44) is used to define MSCs, identification of functionally relevant cell surface markers would provide more robust release criteria and options for quality control. In addition, cell surface expression may distinguish between MSCs from different sources, including bone marrow-derived MSCs and clinical-grade adipose-derived MSCs (AMSCs) grown in human platelet lysate (hPL)...
August 11, 2016: Stem Cell Research & Therapy
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