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Adipose Stem Cells and Osteoarthritis

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https://www.readbyqxmd.com/read/29301300/the-impact-of-lipid-types-and-liposomal-formulations-on-osteoblast-adiposity-and-mineralization
#1
Shun-Fu Chang, Chih-Chang Yeh, Pin-Jyun Chen, Hsin-I Chang
Recent studies have demonstrated that fat accumulation in bone cells is detrimental to bone mass. Both adipocytes and osteoblasts are derived from common multipotent mesenchymal stem cells (MSCs) and hence the presence of fat may increase adipocyte proliferation, differentiation and fat accumulation while inhibiting osteoblast differentiation and bone formation. Lipids are common constituents in supramolecular vesicles (e.g., micelles or liposomes) that serve as drug delivery systems. Liposomal formulations such as Meriva® were proven to decrease joint pain and improve joint function in osteoarthritis (OA) patients...
January 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29243770/adipose-derived-stem-cells-in-articular-cartilage-regeneration-current-concepts-and-optimization-strategies
#2
REVIEW
Xingjian Gu, Caixin Li, Feng Yin, Guanghua Yang
Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly incriminated in the physio-pathological mechanism of KOA. While conventional therapies result in unfavorable clinical outcomes, regenerative cell therapies have shown great promise in articular cartilage regeneration...
December 15, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29243283/intra-articular-injection-of-autologous-adipose-derived-mesenchymal-stem-cells-in-treatment-of-knee-osteoarthritis
#3
Duško Spasovski, Vesna Spasovski, Zoran Baščarević, Maja Stojiljković, Miša Vreća, Marina Andjelković, Sonja Pavlović
BACKGROUND: Osteoarthritis (OA) is a chronic degenerative joint disease, considered to be the fourth leading cause of disability and the second cause of inability to work in men. Recently, adipose derived mesenchymal stem cells (AD-MSCs) came in focus of regenerative medicine as promising tool for treatment of OA. It has been shown that administration of stem cells into impaired joints results in pain relief and improves quality of life, accompanied with restoration of hyaline articular cartilage...
December 15, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29238343/thrombospondin-1-partly-mediates-the-cartilage-protective-effect-of-adipose-derived-mesenchymal-stem-cells-in-osteoarthritis
#4
Marie Maumus, Cristina Manferdini, Karine Toupet, Paul Chuchana, Louis Casteilla, Mélanie Gachet, Christian Jorgensen, Gina Lisignoli, Danièle Noël
Objective: Assuming that mesenchymal stem cells (MSCs) respond to the osteoarthritic joint environment to exert a chondroprotective effect, we aimed at investigating the molecular response setup by MSCs after priming by osteoarthritic chondrocytes in cocultures. Methods: We used primary human osteoarthritic chondrocytes and adipose stem cells (ASCs) in mono- and cocultures and performed a high-throughput secretome analysis. Among secreted proteins differentially induced in cocultures, we identified thrombospondin-1 (THBS1) as a potential candidate that could be involved in the chondroprotective effect of ASCs...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29230269/extracellular-vesicles-from-adipose-derived-mesenchymal-stem-cells-downregulate-senescence-features-in-osteoarthritic-osteoblasts
#5
Miguel Tofiño-Vian, Maria Isabel Guillén, María Dolores Pérez Del Caz, Miguel Angel Castejón, Maria José Alcaraz
Osteoarthritis (OA) affects all articular tissues leading to pain and disability. The dysregulation of bone metabolism may contribute to the progression of this condition. Adipose-derived mesenchymal stem cells (ASC) are attractive candidates in the search of novel strategies for OA treatment and exert anti-inflammatory and cytoprotective effects on cartilage. Chronic inflammation in OA is a relevant factor in the development of cellular senescence and joint degradation. In this study, we extend our previous observations of ASC paracrine effects to study the influence of conditioned medium and extracellular vesicles from ASC on senescence induced by inflammatory stress in OA osteoblasts...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29156945/modulation-of-gene-expression-in-infrapatellar-fat-pad-derived-mesenchymal-stem-cells-in-osteoarthritis
#6
Beatriz Bravo, Jose Manuel Argüello, Arancha R Gortazar, Francisco Forriol, Javier Vaquero
Aim In the osteoarthritis (OA) disease, all structures of the joint are involved. The infrapatellar Hoffa fat pad is rich in macrophages and granulocytes, which also represents a source of adipose mesenchymal progenitor cells (ASC) cells. In our study, we analyze how OA affects the ability of ASC-derived from Hoffa's fat pad to differentiate into chondrocytes. Material and methodology We took knee Hoffa's pad samples and adipose tissue from the proximal thigh from 6 patients diagnosed with severe OA and from another 6 patients with an anterior cruciate ligament (ACL) rupture without OA...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29131526/amniotic-mesenchymal-stem-cells-mitigate-osteoarthritis-progression-in-a-synovial-macrophage-mediated-in-vitro-explant-co-culture-model
#7
Natasha Topoluk, Kathleen Steckbeck, Sandra Siatkowski, Brian Burnikel, John Tokish, Jeremy Mercuri
Osteoarthritis (OA) is a disease of the synovial joint marked by chronic, low-grade inflammation leading to cartilage destruction. Regenerative medicine strategies for mitigating OA progression and/or promoting cartilage regeneration must be assessed using models that mimic the hallmarks of OA. More specifically, these models should maintain synovial macrophage phenotype in their native micro-environment. Herein, an in vitro co-culture model of patient-matched human OA cartilage and synovium was assessed for viability, macrophage phenotype, and progressive cartilage destruction in the presence of an inflammatory milieu...
November 13, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29118440/native-joint-resident-mesenchymal-stem-cells-for-cartilage-repair-in-osteoarthritis
#8
REVIEW
Dennis McGonagle, Thomas G Baboolal, Elena Jones
The role of native (not culture-expanded) joint-resident mesenchymal stem cells (MSCs) in the repair of joint damage in osteoarthritis (OA) is poorly understood. MSCs differ from bone marrow-residing haematopoietic stem cells in that they are present in multiple niches in the joint, including subchondral bone, cartilage, synovial fluid, synovium and adipose tissue. Research in experimental models suggests that the migration of MSCs adjacent to the joint cavity is crucial for chonodrogenesis during embryogenesis, and also shows that synovium-derived MSCs might be the primary drivers of cartilage repair in adulthood...
December 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29099618/intra-articular-mesenchymal-stem-cell-therapy-for-the-human-joint-a-systematic-review
#9
James A McIntyre, Ian A Jones, Bo Han, C Thomas Vangsness
BACKGROUND: Stem cell therapy is emerging as a potential treatment of osteoarthritis (OA) and chondral defects (CDs). However, there is a great deal of heterogeneity in the literature. The indications for stem cell use, the ideal tissue source, and the preferred outcome measures for stem cell-based treatments have yet to be determined. PURPOSE: To provide clinicians with a comprehensive overview of the entire body of the current human literature investigating the safety and efficacy of intra-articular mesenchymal stem cell (MSC) therapy in all joints...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29053693/in-vivo-tracking-of-human-adipose-derived-mesenchymal-stem-cells-in-a-rat-knee-osteoarthritis-model-with-fluorescent-lipophilic-membrane-dye
#10
Meng Li, Ming Hao, Dong Jiang, Yanxi Chen, Wen Wang
In order to support the clinical application of human adipose-derived mesenchymal stem cell (haMSC) therapy for knee osteoarthritis (KOA), we examined the efficacy of cell persistence and biodistribution of haMSCs in animal models. We demonstrated a method to label the cell membrane of haMSCs with lipophilic fluorescent dye. Subsequently, intra-articular injection of the labeled cells in rats with surgically induced KOA was monitored dynamically by an in vivo imaging system. We employed the lipophilic carbocyanines DiD (DilC18 (5)), a far-red fluorescent Dil (dialkylcarbocyanines) analog, which utilized a red laser to avoid excitation of the natural green autofluorescence from surrounding tissues...
October 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29038190/effect-of-autologous-adipose-derived-mesenchymal-stem-cell-therapy-in-the-treatment-of-a-post-traumatic-chondral-defect-of-the-knee
#11
Julien Freitag, Douglas Li, James Wickham, Kiran Shah, Abi Tenen
Isolated chondral defects have a limited capacity to heal and predispose to the development of osteoarthritis. Current surgical management can be unpredictable in outcome. Improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repair. A 26-year-old athlete presented with a post-traumatic, isolated patella chondral defect. The patient underwent an arthroscopy with removal of a chondral loose body. After failure to symptomatically improve 12 months following surgery, the patient received intra-articular autologous adipose-derived mesenchymal stem cell (ADMSC) therapy...
October 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29030067/adipose-tissue-derived-stem-cells-in-combination-with-xanthan-gum-attenuate-osteoarthritis-progression-in-an-experimental-rat-model
#12
Li Mei, Bojiang Shen, Jiajun Xue, Shaoying Liu, Aibin Ma, Fuyan Liu, Huarong Shao, Jianying Chen, Qixin Chen, Fei Liu, Yong Ying, Peixue Ling
The current study explored the efficacy of an intra-articular (IA) injection of allogeneic adipose tissue-derived stem cells (ADSCs) combined with xanthan gum (XG) in a rat osteoarthritis (OA) model. We confirmed that XG significantly inproved proliferation of ADSCs in a dose dependent manner in vitro. The rat OA model was induced by an anterior cruciate ligament transection (ACLT), and at 4 weeks after surgery, rats were divided into four groups: the XG-ADSCs group, the ADSCs group, the XG group and the phosphate-buffered saline (PBS) group...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28993845/-new-experimental-strategies-in-cartilage-surgery
#13
REVIEW
L Rackwitz, J C Reichert, O Pullig, U Nöth
BACKGROUND: Cell and growth factor based strategies bear great potential to support the healing processes in cartilage repair and the therapy of osteoarthritic joints. OBJECTIVES: The following review provides an overview of novel experimental strategies for the therapy of focal cartilage defects and osteoarthritis, with emphasis on cell and growth factor based approaches. MATERIALS AND METHODS: The authors summarize their own data regarding the intraarticular injection of stem cells to treat osteoarthritis of the knee and provide a synopsis of the available literature discussing the most significant publications...
November 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28986619/-therapeutic-utilization-of-stem-cells-in-orthopedics
#14
C Chiari, S Walzer, D Stelzeneder, M Schreiner, R Windhager
Stem cells are becoming increasingly more important in the field of regenerative medicine. Adult mesenchymal stem cells (MSCs) are harvested predominantly from bone marrow or adipose tissue, are already being used in the clinical setting and have a low potential for side effects. In orthopedics, experience has been gained in the treatment of bone defects, non-unions, cartilage defects, osteoarthritis and tendon pathologies. The current data are derived from case studies and randomized controlled trials are missing; therefore, there are many open questions concerning the optimal cell source, number of cells, administration technique (e...
October 6, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28975547/autologous-and-micro-fragmented-adipose-tissue-for-the-treatment-of-diffuse-degenerative-knee-osteoarthritis
#15
A Russo, V Condello, V Madonna, M Guerriero, C Zorzi
BACKGROUND: Chondral lesions of the knee represent a challenge for the orthopaedic surgeon. Several treatments have been proposed with variable success rate. Recently, new therapeutic approaches, such as the use of mesenchymal stem cells, have shown promising results. The adipose tissue is a good source of these naturally occurring regenerative cells, due to its abundance and easy access. In addition, it can be used to provide cushioning and filling of structural defects. The 1-year safety and outcome of a single intra-articular injection of autologous and micro-fragmented adipose tissue in 30 patients affected by diffuse degenerative chondral lesions was evaluated...
October 3, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28951745/in-vivo-articular-cartilage-regeneration-using-human-dental-pulp-stem-cells-cultured-in-an-alginate-scaffold-a-preliminary-study
#16
Manuel Mata, Lara Milian, Maria Oliver, Javier Zurriaga, Maria Sancho-Tello, Jose Javier Martin de Llano, Carmen Carda
Osteoarthritis is an inflammatory disease in which all joint-related elements, articular cartilage in particular, are affected. The poor regeneration capacity of this tissue together with the lack of pharmacological treatment has led to the development of regenerative medicine methodologies including microfracture and autologous chondrocyte implantation (ACI). The effectiveness of ACI has been shown in vitro and in vivo, but the use of other cell types, including bone marrow and adipose-derived mesenchymal stem cells, is necessary because of the poor proliferation rate of isolated articular chondrocytes...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28833807/the-wnt5a-receptor-receptor-tyrosine-kinase-like-orphan-receptor-2-is-a-predictive-cell-surface-marker-of-human-mesenchymal-stem-cells-with-an-enhanced-capacity-for-chondrogenic-differentiation
#17
Sally C Dickinson, Catherine A Sutton, Kyla Brady, Anna Salerno, Theoni Katopodi, Rhys L Williams, Christopher C West, Denis Evseenko, Ling Wu, Suzanna Pang, Roberta Ferro de Godoy, Allen E Goodship, Bruno Péault, Ashley W Blom, Wael Kafienah, Anthony P Hollander
Multipotent mesenchymal stem cells (MSCs) have enormous potential in tissue engineering and regenerative medicine. However, until now, their development for clinical use has been severely limited as they are a mixed population of cells with varying capacities for lineage differentiation and tissue formation. Here, we identify receptor tyrosine kinase-like orphan receptor 2 (ROR2) as a cell surface marker expressed by those MSCs with an enhanced capacity for cartilage formation. We generated clonal human MSC populations with varying capacities for chondrogenesis...
November 2017: Stem Cells
https://www.readbyqxmd.com/read/28769981/human-suprapatellar-fat-pad-derived-mesenchymal-stem-cells-induce-chondrogenesis-and-cartilage-repair-in-a-model-of-severe-osteoarthritis
#18
Ignacio Muñoz-Criado, Jose Meseguer-Ripolles, Maravillas Mellado-López, Ana Alastrue-Agudo, Richard J Griffeth, Jerónimo Forteza-Vila, Ramón Cugat, Montserrat García, Victoria Moreno-Manzano
Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). Spontaneous cartilage regeneration is extremely limited. Often the treatment consists of a partial or complete joint implant. Adipose-derived stem cell (ASC) transplantation has been shown to restore degenerated cartilage; however, regenerative differences of ASC would depend on the source of adipose tissue. The infra- and suprapatellar fat pads surrounding the knee offer a potential autologous source of ASC for patients after complete joint substitution...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28746812/intra-articular-injection-of-mesenchymal-stem-cells-for-the-treatment-of-osteoarthritis-of-the-knee-a-2-year-follow-up-study
#19
Chris Hyunchul Jo, Jee Won Chai, Eui Cheol Jeong, Sohee Oh, Ji Sun Shin, Hackjoon Shim, Kang Sup Yoon
BACKGROUND: The intra-articular injection of mesenchymal stem cells (MSCs) into the knee has shown a potential for the treatment of generalized cartilage loss in osteoarthritis (OA). However, there have been few midterm reports with clinical and structural outcomes. PURPOSE: To assess the midterm safety and efficacy of an intra-articular injection of autologous adipose tissue-derived (AD) MSCs for knee OA at 2-year follow-up. STUDY DESIGN: Cohort study; Level of evidence, 3...
October 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28705238/interleukin-3-enhances-the-migration-of-human-mesenchymal-stem-cells-by-regulating-expression-of-cxcr4
#20
Amruta Barhanpurkar-Naik, Suhas T Mhaske, Satish T Pote, Kanupriya Singh, Mohan R Wani
BACKGROUND: Mesenchymal stem cells (MSCs) represent an important source for cell therapy in regenerative medicine. MSCs have shown promising results for repair of damaged tissues in various degenerative diseases in animal models and also in human clinical trials. However, little is known about the factors that could enhance the migration and tissue-specific engraftment of exogenously infused MSCs for successful regenerative cell therapy. Previously, we have reported that interleukin-3 (IL-3) prevents bone and cartilage damage in animal models of rheumatoid arthritis and osteoarthritis...
July 14, 2017: Stem Cell Research & Therapy
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