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https://www.readbyqxmd.com/read/28636886/sirt1-enzymatically-potentiates-1-25-dihydroxyvitamin-d3-signaling-via-vitamin-d-receptor-deacetylation
#1
Marya S Sabir, Chengcheng Hu, Zainab Khan, Michael A Galligan, Christopher M Dussik, Sanchita Mallick, Angelika Dampf Stone, Shane F Batie, Elizabeth T Jacobs, G Kerr Whitfield, Mark R Haussler, Michael C Heck, Peter W Jurutka
The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Herein, it is revealed for the first time that VDR is post-translationally acetylated, and that VDR immunoprecipitated from human embryonic kidney (HEK293) cells displays a dramatic decrease in acetylated receptor in the presence of 1,25D-ligand, sirtuin-1 (SIRT1) deacetylase, or the resveratrol activator of SIRT1...
June 18, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28636506/incidence-and-predictors-of-atrial-fibrillation-after-coronary-artery-bypass-surgery-detection-by-event-loop-recorder-monitoring-from-a-contemporary-multicentre-cohort
#2
Zainab Abdel-Salam, Wail Nammas
Background Atrial fibrillation (AF) is a frequent complication after cardiac surgery. We explored the incidence and predictors of post-operative AF at 30-day follow-up in an unselected multi-centre cohort of patients undergoing elective coronary artery bypass grafting (CABG) in contemporary practice. Methods and results We enrolled 740 consecutive patients scheduled for elective CABG with or without valve surgery. Cardiac rhythm was continuously monitored for 15 days after surgery by an ambulatory event loop recorder...
March 21, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28632940/characterization-of-the-i4399m-variant-of-apolipoprotein-a-implications-for-altered-prothrombotic-properties-of-lipoprotein-a
#3
Corey A Scipione, Jackson T McAiney, Daniel J Simard, Zainab A Bazzi, Matthew Gemin, Rocco Romagnuolo, Fraser L Macrae, Robert A Ariëns, Robert A Hegele, Janeen Auld, James W Gauld, Michael B Boffa, Marlys L Koschinsky
BACKGROUND: Lipoprotein(a) (Lp(a)) is a causal risk factor for a variety of cardiovascular diseases. Apolipoprotein(a) (apo(a)), the distinguishing component of Lp(a), is homologous to plasminogen, suggesting that Lp(a) can interfere with the normal fibrinolytic functions of plasminogen. This has implications for the persistence of fibrin clots in the vasculature and hence to atherothrombotic diseases. A single nucleotide polymorphism (rs3798220) in the gene encoding apo(a) has been reported that results in an Ile to Met substitution in the protease-like domain (I4399M variant)...
June 20, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28626132/performance-of-palm-based-c16-18-methyl-ester-sulphonate-mes-in-liquid-detergent-formulation
#4
Zulina Abd Maurad, Zainab Idris, Razmah Ghazali
Liquid detergents are more convenient than powdered detergents as they dissolve readily in water, generate less dust and dosing is easy. However, the stability of liquid detergents is an issue of concern. Therefore, the objective of this research is to study the formulation requirement to produce heavy-duty liquid detergents based on palm-based methyl esters sulphonate (MES) with desirable properties and performance. MES is produced from renewable and sustainable feedstock suitable to replace the conventional fossil-based surfactant, linear alkyl benzene sulphonates (LAS)...
June 13, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28614716/the-notch1-snail1-mef2c-pathway-regulates-growth-and-self-renewal-in-embryonal-rhabdomyosarcoma
#5
Myron S Ignatius, Madeline N Hayes, Riadh Lobbardi, Eleanor Y Chen, Karin M McCarthy, Prethish Sreenivas, Zainab Motala, Adam D Durbin, Aleksey Molodtsov, Sophia Reeder, Alexander Jin, Sivasish Sindiri, Brian C Beleyea, Deepak Bhere, Matthew S Alexander, Khalid Shah, Charles Keller, Corinne M Linardic, Petur G Nielsen, David Malkin, Javed Khan, David M Langenau
Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are largely unknown, especially in embryonal rhabdomyosarcoma (ERMS)-a common pediatric cancer of muscle. Here, we used a zebrafish transgenic model of ERMS to identify a role for intracellular NOTCH1 (ICN1) in increasing TPCs by 23-fold. ICN1 expanded TPCs by enabling the de-differentiation of zebrafish ERMS cells into self-renewing myf5+ TPCs, breaking the rigid differentiation hierarchies reported in normal muscle...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28605545/atypical-forms-of-congenital-hyperinsulinism-in-infancy-are-associated-with-mosaic-patterns-of-immature-islet-cells
#6
Bing Han, Zainab Mohamed, Maria Salomon Estebanez, Ross J Craigie, Melanie Newbould, Edmund Cheesman, Raja Padidela, Mars Skae, Matthew Johnson, Sarah Flanagan, Sian Ellard, Karen E Cosgrove, Indraneel Banerjee, Mark J Dunne
Objectives: We aimed to characterise mosaic populations of pancreatic islet cells from patients with atypical CHI (CHI-A) and the expression profile of NKX2.2, a key transcription factor expressed in β-cells but suppressed in δ-cells in the mature pancreas. Patients/Methods: Tissue was isolated from three patients with CHI-A following subtotal pancreatectomy. CHI-A was diagnosed on the basis of islet mosaicism and the absence of histopathological hallmarks of focal- and diffuse CHI (CHI-D)...
June 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28603552/problem-management-plus-pm-in-the-management-of-common-mental-disorders-in-a-specialized-mental-healthcare-facility-in-pakistan-study-protocol-for-a-randomized-controlled-trial
#7
Syed Usman Hamdani, Zainab Ahmed, Marit Sijbrandij, Huma Nazir, Aqsa Masood, Parveen Akhtar, Hania Amin, Richard A Bryant, Katie Dawson, Mark van Ommeren, Atif Rahman, Fareed Aslam Minhas
BACKGROUND: The World Health Organization (WHO) has developed Problem Management Plus (PM+), a 5-session, psychological intervention program delivered by trained non-specialist that addresses common mental disorders. The objectives of this study are to evaluate effectiveness and cost-effectiveness of PM+ in a specialized mental health care facility in Pakistan. METHODS: A single blind individual randomized controlled trial (RCT) will be carried out in the outpatient department of a specialized mental healthcare facility in Rawalpindi, Pakistan...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28600960/disability-from-pain-directly-correlated-with-depression-in-parkinson-s-disease
#8
Abdul Qayyum Rana, Abdul-Rahman M Qureshi, Nabiha Rehman, Aisha Mohammed, Zainab Sarfraz, Ruqqiyah Rana
OBJECTIVE: Parkinson's disease (PD) is a progressively debilitating disorder resulting in reduced quality of life (QoL). Along with the motor symptoms of PD, non-motor symptoms of PD such as pain, restless leg syndrome (RLS) depression also occur. These exacerbate the worsening QoL and must be promptly diagnosed and treated. The objective of this study was to determine the relationship between pain severity, walking, general activity and work (WAW) and rapid eye movements (REM) dimensions of pain interference, and disability with depression and RLS in PD...
May 30, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28596801/tobacco-in-post-conflict-settings-the-case-of-iraq
#9
REVIEW
Zainab Hussain, Richard Sullivan
Tobacco is the leading cause of preventable death in the world, claiming six million lives each year. Although smoking prevalence is decreasing in high-income countries, many low- and middle-income countries, particularly fragile and post-conflict nations such as Iraq, are still seeing prevalence rates rising. With the evidence of higher rates of nicotine dependence in conflict and post-conflict areas, the tobacco problem only becomes more difficult for Iraq, which finds itself involved in conflicts lasting years, if not decades...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28591011/being-fully-present-gains-patients-attribute-to-a-telephone-delivered-parenting-program-for-child-rearing-mothers-with-cancer
#10
Amy J Walker, Frances M Lewis, Hebah Al-Mulla, Zainab Alzawad, Nai-Ching Chi
BACKGROUND: Oncology nurses can assist patients in gaining skills and confidence in multiple areas of illness self-management, including parenting skills. Child-rearing parents with cancer are a unique population because they must self-manage their illness and also help their child manage the intrusion of cancer on everyday life. The telephone offers an inexpensive channel for nurses to assist mothers in developing competencies to parent their child. The acceptability and attributed gains from such telephone services are unknown...
June 7, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28588804/peripartum-cardiomyopathy-what-if-your-patient-plans-to-reconceive
#11
Rashed Al Bannay, Aysha Husain, Zainab AlJufairi
Patients with peripartum cardiomyopathy (PPCM) often express a desire to conceive again, and the risk of relapse in future pregnancies should be disclosed. No consensus is available that can determine that risk. Adequate contractile reserve, evidenced by a stress echocardiogram (exercise or dobutamine), can identify those with lower relapse risk.
June 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28579787/the-impact-of-comorbid-psychiatric-disorders-on-methadone-maintenance-treatment-in-opioid-use-disorder-a-prospective-cohort-study
#12
Tea Rosic, Leen Naji, Monica Bawor, Brittany B Dennis, Carolyn Plater, David C Marsh, Lehana Thabane, Zainab Samaan
OBJECTIVE: There is a significant interindividual variability in treatment outcomes in methadone maintenance treatment (MMT) for opioid use disorder (OUD). This prospective cohort study examines the impact of comorbid psychiatric disorders on continued illicit opioid use in patients receiving MMT for OUD. METHODS: Data were collected from 935 patients receiving MMT in outpatient clinics between June 2011 and June 2015. Using linear regression analysis, we evaluated the impact of having a comorbid psychiatric disorder on continued illicit opioid use during MMT, adjusting for important confounders...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28579369/getting-a-manual-wheelchair-over-a-threshold-using-the-momentum-method-a-descriptive-study-of-common-errors
#13
Zainab Al Lawati, R Lee Kirby, Cher Smith, Diane MacKenzie, Chris Theriault, Kara Matheson
OBJECTIVES: To document the success of learners' attempts to overcome a threshold in a manual wheelchair while using the momentum method, to describe the frequency and nature of any errors observed and to compare the characteristics of participants who were or were not successful on their first attempts. DESIGN: Cross-sectional, observational study following STROBE guidelines. PARTICIPANTS: 214 able-bodied students learning the threshold skill...
June 1, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28566976/health-education-to-diabetic-patients-before-the-start-of-ramadan-experience-from-a-teaching-hospital-in-dammam
#14
Rayyan M Al-Musally, Mais A Al-Sardi, Zainab A Al-Elq, Afnan H Elahi, Rawan K Alduhailan, Muslim A Al-Elq, Fatma A Zainuddin, Noura A Alsafar, Jannat A Altammar, Abdulmohsen H Al-Elq
BACKGROUND AND OBJECTIVE: Studies have shown that pre-Ramadan structured educational program for patients with diabetes mellitus (DM) is beneficial. In this study, our aim was to evaluate the degree of adherence of treating physicians to such programs and their influence on the patient's knowledge and behavior. MATERIALS AND METHODS: This cross-sectional study was carried out on adult patients with DM attending a university hospital, who were observed while fasting during Ramadan 1436/2015...
May 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28549088/quantitative-association-between-peripapillary-bruch-s-membrane-shape-and-intracranial-pressure
#15
Amulya Gampa, Gautam Vangipuram, Zainab Shirazi, Heather E Moss
Purpose: The purpose of this study was to determine if there is a quantitative relationship between chronic intracranial pressure (ICP) and peripapillary Bruch's membrane (pp-BM) shape and to determine whether change in pp-BM shape can be detected within 1 hour after ICP lowering by lumbar puncture (LP). Methods: In this study, 30° nasal-temporal optical coherence tomography B-scans were obtained within 1 hour before and after LP in 39 eyes from 20 patients (age = 23-86 years, 75% female, ICP [opening pressure] = 10-55 cm H2O)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28548371/the-additional-utility-of-two-dimensional-strain-in-detection-of-coronary-artery-disease-presence-and-localization-in-patients-undergoing-dobutamine-stress-echocardiogram
#16
Alaa Roushdy, Yomna Abou El Seoud, Mohamed Abd Elrahman, Basem Wadeaa, Adel Eletriby, Zainab Abd El Salam
BACKGROUND: Dobutamine stress echocardiogram (DSE) is a feasible and safe exercise-independent stress modality for diagnoses of coronary artery disease (CAD), but it is subjective, and operator dependant. Two-dimensional strain at peak stress could overcome these limitations and thus increase the accuracy of DSE. METHODS AND RESULTS: This was a prospective observational study in which 80 patients underwent DSE, two-dimensional strain at peak stress, and coronary angiography...
May 26, 2017: Echocardiography
https://www.readbyqxmd.com/read/28541793/inhibition-of-secreted-aspartyl-proteinase-activity-in-biofilms-of-candida-species-by-mycogenic-silver-nanoparticles
#17
Sabahat Hamid, Shama Zainab, Rani Faryal, Naeem Ali, Iqra Sharafat
Candida species are pleomorphic, commensal fungi associated with candidiasis. The extracellular hydrolytic-secreted aspartyl proteinases are recognized as chief agents for pathogenesis of Candida species, involved in the degradation of proteins and adhesion during biofilm formation. This study aimed at exploring inhibitory effect of mycogenic silver nanoparticles (Ag NPs) against C. albicans and non-albicans' biofilm growth and aspartyl proteinase enzyme activity in-vitro. Biofilm forming, drug-resistant clinical isolates of C...
May 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28536234/actinomycosis-presenting-as-an-anterior-abdominal-mass-after-laparoscopic-cholecystectomy
#18
Zainab Alhumoud, Amro Salem
Abdominal actinomycosis is a rare disease caused by different anaerobic Actinomyces species. We report the case of a 55-year-old woman who presented with a painless, slow growing, left upper abdominal mass that developed after a laparoscopic cholecystectomy. A CT scan and MRI of the abdomen revealed a desmoid tumour of the left rectus abdominis muscle.Surgical excision was performed with an uneventful postoperative course. The histological analysis of the specimen was inconsistent with a desmoid tumour and revealed an infection of Actinomyces israelii in the anterior abdominal wall that was confirmed with a microbiology culture...
May 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28536072/characterization-of-astrovirus-associated-gastroenteritis-in-hospitalized-children-under-five-years-of-age
#19
Hassan Zaraket, Hadi Abou-El-Hassan, Khalil Kreidieh, Nadia Soudani, Zainab Ali, Moza Hammadi, Lina Reslan, Soha Ghanem, Farah Hajar, Adlette Inati, Mariam Rajab, Hassan Fakhouri, Bassam Ghanem, Ghassan Baasiri, Nada M Melhem, Ghassan Dbaibo
PURPOSE: The aim of this study was to determine the incidence and genetic diversity of astrovirus (AstV) detected in children hospitalized for gastroenteritis (GE). METHODS: A multi-center, hospital-based surveillance study was conducted across Lebanon to investigate the incidence of AstV among diarrheal hospitalizations. Viral RNA was extracted from stool samples collected between 2011 and 2013 from children, below the age of 5years, hospitalized for GE at six medical centers across Lebanon...
May 20, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28532504/vineland-adaptive-behavior-scales-to-identify-neurodevelopmental-problems-in-children-with-congenital-hyperinsulinism-chi
#20
Maria Salomon-Estebanez, Zainab Mohamed, Maria Michaelidou, Hannah Collins, Lindsey Rigby, Mars Skae, Raja Padidela, Stewart Rust, Mark Dunne, Karen Cosgrove, Indraneel Banerjee, Jacqueline Nicholson
BACKGROUND: Congenital Hyperinsulinism (CHI) is a disease of severe hypoglycaemia caused by excess insulin secretion and associated with adverse neurodevelopment in a third of children. The Vineland Adaptive Behavior Scales Second Edition (VABS-II) is a parent report measure of adaptive functioning that could be used as a developmental screening tool in patients with CHI. We have investigated the performance of VABS-II as a screening tool to identify developmental delay in a relatively large cohort of children with CHI...
May 22, 2017: Orphanet Journal of Rare Diseases
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