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Fawaz Alenezi, Beverly H Brummett, Stephen H Boyle, Zainab Samad, Michael A Babyak, Nabil Alzaeim, Jennifer Wilson, Minna M D Romano, Julia L Sun, Mads Ersboll, Christopher M O'Connor, Eric J Velazquez, Wei Jiang
Mental stress-induced myocardial ischemia is common and a prognostic factor of adverse cardiovascular outcomes in patients with coronary artery disease (CAD). The present study aimed at examining associations between mental stress-induced myocardial annular velocity (MAV) and cardiovascular outcome in patients with CAD. MAV, specifically, diastolic early (e'), diastolic late (a'), and systolic (s') velocities were obtained at rest and during mental stress testing in 224 patients with clinically stable CAD. Using Cox regression models, age, sex, and baseline-adjusted mental stress-induced MAV measures were examined as predictors of a priori defined composite event term that comprised all-cause mortality and/or nonfatal cardiovascular events, resulting in an unplanned hospitalization (major adverse cardiovascular events [MACE])...
July 29, 2017: American Journal of Cardiology
Sherry R Chemler, Shuklendu Karyakarte, Zainab M Khoder
This Perspective describes the development of a family of copper-catalyzed alkene difunctionalization reactions that enable stereoselective addition of amine derivatives and alcohols onto pendant unactivated alkenes to provide a range of valuable saturated nitrogen and oxygen heterocycles. 2-Vinylanilines and related substrates undergo alternative oxidative amination or allylic amination pathways and these reactions will also be discussed. The involvement of both polar and radical steps in the reaction mechanisms have been implicated...
September 14, 2017: Journal of Organic Chemistry
Ibrahim Baffa Sule, Mohammed Yahaya, Abubakar Ahmed Aisha, Ahmed Datti Zainab, Bajoga Ummulkhulthum, Patrick Nguku
INTRODUCTION: Cholera is an acute gastrointestinal infection caused by Vibrio cholerae, which may lead to severe dehydration and death if not treated. This analysis is aimed at highlighting the magnitude, pattern and trend of cholera outbreak that occurred in Kaduna State in 2014. METHODS: We obtained the 2014 cholera line-list from the Kaduna State Disease Surveillance and Notification officer (DSNO). We described the outbreaks in time, place and person using Epi-info 7 and Health Mapper...
2017: Pan African Medical Journal
Marwan S M Al-Nimer, Zainab Wahbee
AIM: Symphytum officinale (comfrey) is a medicinal plant commonly used in decoction and to treat ailments. It protects the skin against ultraviolet (UV)-irradiation. UV irradiation may induce variable effects on the constituents of herbal extracts and thereby may limit or improve the advantages of using these extracts as medicinal supplements. This study aimed to assess the effect of UV radiations including UV-A, UV-B, and UV-C on the constituents of S. officinale aqueous and alcoholic extracts...
July 2017: Journal of Intercultural Ethnopharmacology
Wael Abu Dayyih, Mohammed Hamad, Ahmad Abu Awwad, Eyad Mallah, Zainab Zakarya, Alice Abu Dayyih, Tawfiq Arafat
Enalapril is an angiotensin-converting enzyme inhibitor used for treatment of hypertension and chronic heart disease. Enalaprilat is its active metabolite responsible for the activity. This study aimed to develop and validate a method for enalapril and enalaprilat analysis and to determine the bioequivalence of two tablet formulae of enalapril. LC-MS/MS bioanalytical method was developed and validated and then applied to evaluate the bioavailability of two enalapril formulae. Antihyperglycemic sitagliptin was used as internal standard (IS)...
2017: Journal of Analytical Methods in Chemistry
Heena Zainab, Ameena Sultana, Pramod Jahagirdar
Salivary Duct Carcinoma (SDC) is a distinctive and clinically aggressive adenocarcinoma of salivary origin. It arises from the ductal epithelium, predominantly occurring in the major salivary glands, especially the parotid gland. Here, we report a case of an extensive salivary gland pathology involving the right side of face, possibly arising from the parotid gland in a 25-year-old male patient. On routine histopathology, the tumour mass revealed a papillary pattern of neoplastic ductal epithelial cells showing comedo-like-central necrosis...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
Ali Noman, Zhiqin Liu, Muhammad Aqeel, Madiha Zainab, Muhammad Ifnan Khan, Ansar Hussain, Muhammad Furqan Ashraf, Xia Li, Yahong Weng, Shuilin He
Regulation of spatio-temporal expression patterns of stress tolerance associated plant genes is an essential component of the stress responses. Eukaryotes assign a large amount of their genome to transcription with multiple transcription factors (TFs). Often, these transcription factors fit into outsized gene groups which, in several cases, exclusively belong to plants. Basic leucine zipper domain (bZIP) transcription factors regulate vital processes in plants and animals. In plants, bZIPs are implicated in numerous fundamental processes like seed development, energy balance, and responses to abiotic or biotic stresses...
September 6, 2017: Biotechnology Letters
Amal Ahmed Mohamed, Zainab A Ali-Eldin, Tamer A Elbedewy, Magdy El-Serafy, Fatma A Ali-Eldin, Hossameldin AbdelAziz
AIM: To assess the role of some circulating miRNAs (miR-23a, miR-203, miR338, miR-34, and miR-16) as tumor markers for diagnosis of hepatocellular carcinoma (HCC). METHODS: One hundred and seventy-one subjects were enrolled, 57 patients with HCC, 57 patients with liver cirrhosis (LC) and 57 healthy subjects as control group. Severity of liver disease was assessed by Child Pugh score. Tumor staging was done using Okuda staging system. Quantification of Micro RNA (miR-23a, miR-203, miR338, miR-34, and miR-16) was performed...
August 18, 2017: World Journal of Hepatology
Zainab Sheikh, Klaus Hoeyer
Trust features prominently in a number of policy documents that have been issued in recent years to facilitate data sharing and international collaboration in medical research. However, it often remains unclear what is meant by 'trust'. By exploring a concrete international collaboration between Denmark and Pakistan, we develop a way of unpacking trust that shifts focus from what trust 'is' to what people invest in relationships and what references to trust do for them in these relationships. Based on interviews in both Pakistan and Denmark with people who provide blood samples and health data for the same laboratory, we find that when participants discuss trust they are trying to shape their relationship to researchers while simultaneously communicating important hopes, fears and expectations...
September 5, 2017: Medicine, Health Care, and Philosophy
Zainab Oseni, Hla Hla Than, Edyta Kolakowska, Lauren Chalmers, Borimas Hanboonkunupakarn, Rose McGready
BACKGROUND: Video-based feedback has been shown to aid knowledge retention, skills learning and improve team functionality. We explored the use of video-based feedback and low fidelity simulation for training rural healthcare workers along the Thailand-Myanmar border and Papua New Guinea (PNG) to manage medical emergencies effectively. METHODS: Twenty-four study participants were recruited from three Shoklo Malaria Research Unit clinics along the Thailand-Myanmar border and eight participants from Kudjip Nazarene Hospital, PNG...
August 31, 2017: BMC Medical Education
Zainab Jiyad, Louise Marquart, Peter O'Rourke, Adèle C Green
Actinic keratoses (AKs) are highly dynamic lesions and AK activity has been shown to be associated with squamous cell carcinoma (SCC). We sought to explore risk factors which may affect the 12-month turnover of AKs in organ transplant recipients (OTRs). The number of incident AKs, regressed AKs and net change in AK counts were calculated. Negative binomial regression and Poisson regression models were used to estimate rate ratios (RR) for these 3 outcomes. Among 150 renal and 89 liver OTRs, those who spent > 50% of a typical weekday in the sun had a lower rate of AK regression than those who spent minimal time in the sun during a typical weekday...
August 30, 2017: Acta Dermato-venereologica
Zainab Sadeghi Dehkordi, Banafsheh Yalameha, Abbas Ali Sari
Sarcocystis is a common zoonotic parasite which can be transmitted through ingestion of contaminated, undercooked meat and is a major cause of economic loss in many countries. This study aimed to detect Sarcocystis parasite in processed meat products in Hamedan, Iran. A total of 20 samples of hamburger, sausage, and cocktail were collected from markets from three factories in Hamedan, Iran. The samples were examined by digestion and impression smear methods for detecting Sarcocystis parasite. The results showed that 80% of all tested samples were infected with Sarcocystis...
2017: Comparative Clinical Pathology
Pragati Purbiya, Zainab Mohammedi Golwala, Ayush Manchanda, V Sreenivas, Jacob M Puliyel
OBJECTIVE: To prospectively validate association between the ratio of platelet distribution width (PDW)/platelet count (PCT) and pediatric intensive care unit (PICU) mortality. METHODS: The study was done in the pediatric intensive care unit (PICU). Platelet indices in the first sample taken after admission were used. In this case control analysis, cases were the patients who died in PICU and the survivors served as controls. Consecutive 209 eligible patients over a period of 15 mo from January 2014 through March 2015 were included...
August 26, 2017: Indian Journal of Pediatrics
Mukesh Kumar Singhal, Rumneet Kaur Billing, Nitin Srivastava, Zainab Khan
Successful rehabilitation of a patient should restore function, esthetic, and speech by prosthesis. Treatment modalities vary from patient to patient. Semi-precision attachments and implants offer several advantages over the traditional approach. The aim and objective of this report was to assess a case of a 55-year-old female patient who had lost all her teeth, except maxillary canines #13 and #23 and with severe bone loss in the mandible. Tooth-supported bar attachment was planned for maxilla, and a total of five dental implants were placed in the mandible using a flapless approach aided by radiographic gutta-percha surgical stents over panoramic two-dimensional imaging...
April 2017: Contemporary Clinical Dentistry
Zainab Parveen, Maqsood Sadiq, Faisal Abbas, Rafi Amir-Ud-Din
OBJECTIVE: To identify the socio-economic determinants of home-based and institutional delivery in Pakistan. METHODS: This study has used Pakistan Demographic and Health Survey (PDHS) data collected by the National Institute of Population Studies (NIPS), Islamabad, Pakistan, and Macro International Inc. (now ICF International) Calverton, Maryland, United States. It used three episodes of Pakistan Demographic and Health Survey Data from 1990-91, 2006-07 and 2012-13...
August 2017: JPMA. the Journal of the Pakistan Medical Association
Zainab Baksoellah, Itay Lavy, Lamis Baydoun, Hilde C M Hooijmaijers, Korine van Dijk, Gerrit R J Melles
PURPOSE: To evaluate changes in maximum keratometry (Kmax), corneal higher-order aberrations (HOAs), and densitometry (backscattered light) up to 1 year after UV cross-linking and their possible relation with changes in the visual outcome. METHODS: Retrospective cohort study on 18 eyes of 16 patients, who underwent UV cross-linking after the Dresden protocol for progressive keratoconus or ectasia after laser-assisted in situ keratomileusis. Corrected distance visual acuity (CDVA), Scheimpflug-based corneal tomography, mean image brightness (corneal densitometry) from the anterior 120 μm of the midcornea, and posterior 60 μm of the central 6 mm of the cornea, and HOAs were evaluated...
August 23, 2017: Cornea
Zainab Abdulrahman Beiruti, Srijak Bhatnagar, Halina E Tegetmeyer, Jeanine S Geelhoed, Marc Strous, S Emil Ruff
For the anaerobic remineralization of organic matter in marine sediments, sulfate reduction coupled to fermentation plays a key role. Here, we enriched sulfate-reducing/fermentative communities from intertidal sediments under defined conditions in continuous culture. We transiently exposed the cultures to oxygen or nitrate twice daily and investigated the community response. Chemical measurements, provisional genomes and transcriptomic profiles revealed trophic networks of microbial populations. Sulfate reducers coexisted with facultative nitrate reducers or aerobes enabling the community to adjust to nitrate or oxygen pulses...
August 24, 2017: Environmental Microbiology
Bolajoko O Olusanya, Cecilia A Mabogunje, Zainab O Imam, Abieyuwa A Emokpae
AIM: This study investigated the frequency and predictors of a long hospital stay (LHS) for severe neonatal hyperbilirubinaemia in Nigeria. METHODS: Length of stay (LOS) for severe hyperbilirubinaemia was examined among neonates consecutively admitted to the emergency department of a children's hospital in Lagos from January 2013 to December 2014. The median LOS was used as the cut-off for LHS. Multivariate logistic regression determined the independent predictors of LHS based on demographic and clinical factors significantly associated with the log-transformed LOS in the bivariate analyses...
August 22, 2017: Acta Paediatrica
Zainab Edoo, Michel Arthur, Jean-Emmanuel Hugonnet
β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser or Cys) of transpeptidases results in the opening of the β-lactam ring and in the formation of a stable acyl-enzyme. The acylation reaction is considered as irreversible due to the strain of the β-lactam ring. In contradiction with this widely accepted but poorly demonstrated premise, we show here that the acylation of the L,D-transpeptidase Ldtfm from Enterococcus faecium by the β-lactam nitrocefin is reversible, leading to limited antibacterial activity...
August 22, 2017: Scientific Reports
Maria Shoaib, Syed Ahsanuddin Ahmed, Syed Muhammad Waqar, Zainab Abbasi, Farah Hafiz Yusuf
Oropharyngeal cancers are the most common cancers of head neck region, they are placed amongst the top ten malignancies globally and around 40% of all the cancers in South and South East Asia. Patient's personal behaviour impacts causality more than the environmental factors in the pathology and prognosis of this particular cancer. In our country risk factors are based on poor infrastructure of the health care system, illiteracy, poor socioeconomic status, Betel nut and quid, smokeless and smoke tobacco. We recommend that an active precautionary approach is required to restrict the rising incidence in the oral cancers, particularly due to culturally related risk habits and reluctance to seek early healthcare amongst our people...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
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