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James G Jollis, Hussein R Al-Khalidi, Mayme L Roettig, Peter B Berger, Claire C Corbett, Shannon Doerfler, Christopher B Fordyce, Timothy D Henry, Lori Hollowell, Zainab Magdon-Ismail, Ajar Kochar, James J McCarthy, Lisa Monk, Peter K O'Brien, Thomas D Rea, Jay Shavadia, Jacqueline Tamis-Holland, B Hadley Wilson, Khaled M Ziada, Christopher B Granger
Background: Regional variations in reperfusion times and mortality in patients with ST-segment elevation myocardial infarction (STEMI) are influenced by differences in coordinating care between emergency medical services (EMS) and hospitals. Building on the Accelerator-1 Project, we hypothesized that time to reperfusion could be further reduced with enhanced regional efforts. Methods: Between April 2015 and March 2017, we worked with 12 metropolitan regions across the United States with 132 PCI-capable hospitals and 946 EMS agencies...
November 14, 2017: Circulation
Magnus Ekström, Zainab Ahmadi, Hillevi Larsson, Tove Nilsson, Josefin Wahlberg, Kerstin E Ström, Bengt Midgren
Background: Long-term oxygen therapy (LTOT) improves prognosis in COPD with severe hypoxemia. However, adherence to criteria for eligibility and quality of LTOT is often insufficient and varies between countries. The aim of this study was to evaluate a national structure for prescription and management of LTOT over three decades in Sweden. Methods: The study was a prospective, population-based study of 23,909 patients on LTOT from 1987 to 2015 in the Swedish National Register of Respiratory Failure (Swedevox)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
Marcus Caine, Xunli Zhang, Martyn Hill, Wei Guo, Koorosh Ashrafi, Zainab Bascal, Hugh Kilpatrick, Anthony Dunn, David Grey, Rosemary Bushby, Andrew Bushby, Sean L Willis, Matthew R Dreher, Andrew L Lewis
The purpose of this study was to evaluate LC Bead LUMI™ (40-90µm and 70-150µm) in order to determine if their increased resistance to compression influences microsphere penetration and distribution compared to more compressible commercial microspheres. LC Bead LUMI™ 40-90µm and 70-150µm, LC BeadM1(®) 70-150µm, Embozene™ 40µm and Embozene™ 100µm size and distributions were measured using optical microscopy. Penetration in vitro was evaluated using an established 'plate model', consisting of a calibrated tapered gap between a glass plate and plastic housing to allow visual observation of microsphere penetration depth...
October 31, 2017: Journal of the Mechanical Behavior of Biomedical Materials
Elisa Lanfranchi, Birgit Grill, Zainab Raghoebar, Sander van Pelt, Roger Sheldon, Kerstin Steiner, Anton Glieder, Margit Winkler
Hydroxynitrile lyase from the white rabbit's foot fern Davallia tyermanii (DtHNL) catalyzes the enantioselective synthesis of α-cyanohydrins, key building blocks for pharmaceutical and agrochemical industries. An efficient and competitive process necessitates the availability and robustness of the biocatalyst. Herein, the recombinant production of DtHNL1 in Komagataella phaffii is described, yielding approximately 900,000 U/L. DtHNL1 constitutes approximately 80% of the total protein content. The crude enzyme was immobilized...
November 13, 2017: Chembiochem: a European Journal of Chemical Biology
Johannes A Spoor, J Wolter Oosterhuis, Remko Hersmus, Katharina Biermann, Katja P Wolffenbuttel, Martine Cools, Zainab Kazmi, Syed F Ahmed, Leendert H J Looijenga
Malignant gonadal germ cell tumors, referred to as germ cell cancers (GCC), occur with increased frequency in individuals who have specific types of differences (disorders) of sex development (DSD). Recent population-based studies have identified new environmental and genetic risk factors that have led to a 'genvironment' hypothesis, which may potentially be helpful in risk assessment in DSD-related GCC. In DSD, the malignancy risk is highly heterogeneous, but recent studies allow now to discriminate between high- and low-risk conditions...
November 3, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
Afsha Aurshina, Anil Hingorani, Amrit Hingorani, Ayisha Zainab, Natalie Marks, Sheila Blumberg, Enrico Ascher
Objective In order to examine the academic productivity of US vascular surgery program directors, the number of vascular publications listed in PubMed from 2001 to 2015 for US vascular surgery program directors was reviewed. We suggest that this can be used as a benchmark for academic productivity. Methods The names of the program directors were taken from the Accreditation Council for Graduate Medical Education (ACGME) website at two time points: December 2009 (Independent Programs) and December 2015 (Independent + Integrated)...
January 1, 2017: Vascular
Hai-Tsang Huang, Dennis Dobrovolsky, Joshiawa Paulk, Guang Yang, Ellen L Weisberg, Zainab M Doctor, Dennis L Buckley, Joong-Heui Cho, Eunhwa Ko, Jaebong Jang, Kun Shi, Hwan Geun Choi, James D Griffin, Ying Li, Steven P Treon, Eric S Fischer, James E Bradner, Li Tan, Nathanael S Gray
Heterobifunctional molecules that recruit E3 ubiquitin ligases, such as cereblon, for targeted protein degradation represent an emerging pharmacological strategy. A major unanswered question is how generally applicable this strategy is to all protein targets. In this study, we designed a multi-kinase degrader by conjugating a highly promiscuous kinase inhibitor with a cereblon-binding ligand, and used quantitative proteomics to discover 28 kinases, including BTK, PTK2, PTK2B, FLT3, AURKA, AURKB, TEC, ULK1, ITK, and nine members of the CDK family, as degradable...
November 7, 2017: Cell Chemical Biology
Abdullah Shuaib, Ali Shuaib, Zainab Fakhra, Bader Marafi, Khalid Alsharaf, Abdullah Behbehani
BACKGROUND: Acute appendicitis is the most common surgical condition presented in emergency departments worldwide. Clinical scoring systems, such as the Alvarado and modified Alvarado scoring systems, were developed with the goal of reducing the negative appendectomy rate to 5%-10%. The Raja Isteri Pengiran Anak Saleha Appendicitis (RIPASA) scoring system was established in 2008 specifically for Asian populations. The aim of this study was to compare the modified Alvarado with the RIPASA scoring system in Kuwait population...
2017: World Journal of Emergency Medicine
Nousheen Iqbal, Xianfeng Wang, Aijaz Ahmed Babar, Ghazala Zainab, Jianyong Yu, Bin Ding
Increasing use of wearable electronic devices have resulted in enhanced demand for highly flexible supercapacitor electrodes with superior electrochemical performance. In this study, flexible composite membranes with electrosprayed MnO2 particles uniformly anchored on Fe3O4 doped electrospun carbon nanofibers (Fe3O4@CNFMn) have been prepared as flexible electrodes for high-performance supercapacitors. The interconnected porous beaded structure ensures free movement of electrolyte within the composite membranes, therefore, the developed supercapacitor electrodes not only offer high specific capacitance of ~306 F/g, but also exhibit good capacitance retention of ~85% after 2000 cycles, which certify that the synthesized electrodes offer high and stable electrochemical performance...
November 9, 2017: Scientific Reports
Safa A Al-Shaikh, Aalaa M Mubarak, Zainab F Harb
Splenic lymphangiomas are exceedingly rare benign neoplasms that occur mainly in children. They are commonly seen in the neck and axillary region. Abdominal lymphangiomas accounts for less than 5% of cases. So far, fewer than 100 cases of spleen lymphangiomas have been reported in the literature. In this paper, we present one case of solitary splenic lymphangioma in a 34-year-old woman who presented with abdominal pain and weight loss for one month. The patient underwent splenectomy and diagnosis was confirmed by histopathology and immunohistochemistry studies...
November 2017: Saudi Medical Journal
Zainab Almooosa, Gasmelseed Y Ahmed, Abeer Omran, Ayah AlSarheed, Afnan Alturki, Abdulaziz Alaqeel, Mohammed Alshehri, Tariq Alfawaz, Dayel AlShahrani
To identify predisposing factors, species distribution, antifungal susceptibility, and outcome. Methods: This study is a retrospective chart review that was conducted at a children's hospital at King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia. One hundred twenty-nine children with invasive candidiasis who were admitted between January 2010 and January 2015. Results: The statistical analysis results have revealed a group of risk factors; prematurity in 37 (28.7%) of patients, low birth weight in 42 (32...
November 2017: Saudi Medical Journal
Haniye Sadat Sajadi, Zainab Sadat Sajadi, Farkhondeh Alsadat Sajadi, Mohammad Hadi, Maryam Zahmatkesh
INTRODUCTION: Hospital care transformation plan (HCTP) was implemented, in 2014, with the aim of ensuring all Iranians have fair access to hospital care, mainly in the public sector. It was assumed that HCTP would lead to increased quality and effectiveness of health care in public hospitals. To explore whether HCTP has achieved its aim, this study has investigated the impact of this plan on performance indicators (PIs) of the public hospitals. MATERIALS AND METHODS: This cross-sectional descriptive study was conducted in 2016...
2017: Journal of Education and Health Promotion
Khawla B N Al-Jassim, Yasser S Mahmmod, Zainab M Salem, Azmi Al-Jubury
The understanding of the epidemiology of canine parasitic infections is necessary for an efficient control program to minimize the risk of zoonotic transmission. The objectives of this study were (1) to determine the prevalence of canine gastrointestinal helminths and protozoa in Basra province, Southern Iraq, and (2) to identify the association of epidemiological characteristics (age, breed, gender, and feed type) of dogs with the parasitic infections. A total of 93 fecal samples, collected in the period from December 2014 to June 2015, were examined macroscopically and microscopically for the presence of worm eggs and protozoal oocysts, using centrifugal flotation method...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Majid S Jabir, Ghassan M Sulaiman, Zainab J Taqi, Dong Li
Autophagy is a cellular process for maintaining cellular homeostasis. This process can be induced by different factors, such as immune stimuli and pathogen-associated molecules. Autophagy has an important role in the control of IL-1β secretion by macrophages and other cell types. In present study, we describe a novel role for Iraqi propolis affecting autophagy in controlling the secretion of IL-1β in bone-marrow macrophages (BMDMs). After infection with Pseudomonas aeruginosa in the presence of propolis, the degradation of IL-1β was induced, and the activity of inflammasome was reduced...
November 8, 2017: Microbes and Infection
Zainab H Al-Ghurabi, Saif Saadedeen Abdulrazaq
The aim of the study was to evaluate the benefit of cone beam computed tomography (CBCT) and how to minimize injury to the posterior superior alveolar artery (PSAA) before sinus lift procedure. Cone beam computed tomography scans of 30 maxillary sinuses (15 patients) assessed to determine the location of PSAA presinus lift procedure. The data collected were used to extend the existed literature. The most common location of the PSAA was intraosseous (66.7%), the subantral distance mean was 5 ± 1 mm, and the mean distance of PSAA from the crest was 15 ± 1...
October 27, 2017: Journal of Craniofacial Surgery
Ibrahim Aliyu, Zainab F Ibrahim, Lawal O Teslim, Helen Okhiwu, Igoche David Peter, Godpower Chinedu Michael
BACKGROUND: Sleep is a necessity; it is nourishing, refreshing and healing. The nursing profession is associated with busy and difficult work schedules, especially the running of shifts which has been associated with cardiovascular and metabolic complications. There is a dearth of local data on sleep disorders, especially among nurses. In this study, we evaluated the quality of sleep and the tendency of daytime sleepiness among nurses. SUBJECTS AND METHODS: This study was cross-sectional in nature involving 100 nurses working with Federal Medical Centre Birnin Kebbi, Kebbi State; the study was carried out between October 2016 and February 2017...
July 2017: Nigerian Postgraduate Medical Journal
Muhammad Furrukh, Shiyam Kumar, Khawaja F Zahid, Hanan S Al-Shamly, Zainab A Al-Jabri, Ikram A Burney, Mansour S Al-Moundhri
OBJECTIVES: The incidence of lung cancer in Oman has shown a gradual but definitive increase since 2002. This study aimed to evaluate the demographic and epidemiological characteristics and survival outcomes of patients with non-small-cell lung cancer (NSCLC) at a university hospital in Oman. METHODS: This study was conducted from January to June 2016. A retrospective analysis was performed of consecutive patients diagnosed with NSCLC presenting to the Sultan Qaboos University Hospital (SQUH) in Muscat, Oman, between March 2000 and December 2015...
August 2017: Sultan Qaboos University Medical Journal
Manal A Awad, Eman AlHammadi, Mariam Malalla, Zainab Maklai, Aisha Tariq, Badria Al-Ali, Alaa Al Jameel, Hisham El Batawi
INTRODUCTION: In this cross-sectional study, the level of knowledge and attitude of elementary school teachers regarding traumatic dental injuries (TDI) were assessed. MATERIALS AND METHODS: A questionnaire was distributed to 330 elementary school teachers in 30 randomly selected schools in the Emirates of Sharjah and Dubai. The questionnaire collected information on participants' demographic characteristics, first aid training, and attitude about emergency management of TDI...
2017: International Journal of Dentistry
Laetitia Sütterlin, Zainab Edoo, Jean-Emmanuel Hugonnet, Jean-Luc Mainardi, Michel Arthur
In most bacteria, the essential targets of β-lactam antibiotics are the D,D-transpeptidases that catalyze the last step of peptidoglycan polymerization by forming 4→3 cross-links. The peptidoglycan of Clostridium difficile is unusual since it mainly contains 3→3 cross-links generated by L,D-transpeptidases. To gain insight into the characteristics of C. difficile peptidoglycan cross-linking enzymes, we have purified the three putative C. difficile L,D-transpeptidases paralogues, LdtCd1, LdtCd2, and LdtCd3, which have been previously identified by sequence analysis...
October 23, 2017: Antimicrobial Agents and Chemotherapy
Amama Mahmood, Rida Zainab, Rushda Basir Ahmad, Maryam Saeed, Awais Mehmood Kamboh
Brain Computer Interfaces (BCIs) serve as an integration tool between acquired brain signals and external devices. Precise classification of the acquired brain signals with the least misclassification error is an arduous task. Existing techniques for classification of multi-class motor imagery electroencephalogram (EEG) have low accuracy and are computationally inefficient. This paper introduces a classification algorithm, which uses two frequency ranges, mu and beta rythms, for feature extraction using common spatial pattern (CSP) along with support vector machine (SVM) for classification...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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