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connexin 40

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https://www.readbyqxmd.com/read/27871290/heterozygous-connexin-50-mutation-affects-metabolic-syndrome-attributes-in-spontaneously-hypertensive-rat
#1
Ondřej Šeda, Drahomíra Křenová, Olena Oliyarnyk, Lucie Šedová, Michaela Krupková, František Liška, Blanka Chylíková, Ludmila Kazdová, Vladimír Křen
BACKGROUND: Several members of connexin family of transmembrane proteins were previously implicated in distinct metabolic conditions. In this study we aimed to determine the effects of complete and heterozygous form of connexin50 gene (Gja8) mutation L7Q on metabolic profile and oxidative stress parameters in spontaneously hypertensive inbred rat strain (SHR). METHODS: Adult, standard chow-fed male rats of SHR, heterozygous SHR-Dca+/- and SHR-Dca-/- coisogenic strains were used...
November 21, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27843504/relationship-between-patients-with-clinical-auditory-neuropathy-spectrum-disorder-and-mutations-in-gjb2-gene
#2
Guilherme M de Carvalho, Priscila Z Ramos, Arthur M Castilho, Alexandre C Guimarães, Edi L Sartorato
: The auditory neuropathy is a condition which there is a dyssynchrony in the nerve conduction of the auditory nerve fibers. There is no evidence about the relationship between patients with clinical auditory neuropathy spectrum disorder and mutations in GJB2 gene. There are only two studies about this topic in the medical literature. Connexin 26 (GJB2 gene) mutations are common causes of genetic deafness in many populations and we also being reported in subjects with auditory neuropathy...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27826129/genotypic-and-phenotypic-predictors-of-complete-heart-block-and-recovery-of-conduction-following-surgical-repair-of-congenital-heart-disease
#3
Laura Murray, Andrew H Smith, English C Flack, Kim Crum, Jill Owen, Prince J Kannankeril
BACKGROUND: Complete heart block (CHB) is a major complication after congenital heart surgery. We hypothesized that genetic and clinical factors are associated with the development of postoperative CHB and recovery of atrioventricular (AV) conduction. OBJECTIVE: To identify predictors of CHB and recovery following congenital heart surgery. METHODS: Patients undergoing congenital heart surgery at our institution from September 2007 through June 2015 were prospectively enrolled in a parent study of postoperative arrhythmias...
November 5, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27813566/association-between-44g-a-and-71a-g-polymorphisms-in-the-connexin-40-gene-and-atrial-fibrillation-in-uyghur-and-han-populations-in-xinjiang-china
#4
J Hailati, Y C Yang, L Zhang, P Y He, M Baikeyi, W Muhuyati, Z Q Liu
We aimed to elucidate the association between connexin 40 (Cx40) genetic polymorphisms and atrial fibrillation (AF) in a Chinese population in Xinjiang comprising Uyghur and Han individuals. We enrolled 275 Uyghur and 305 age- and gender-matched Han subjects, and used polymerase chain reaction to detect single nucleotide polymorphisms (SNPs; -44G/A and +71A/G) in the gene encoding Cx40. A mutation screening was performed by direct sequencing and calculation of genotype and allele frequencies among AF patients and control subjects to determine the relationship between these variants and this condition in Uyghur and Han populations...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27766024/role-of-cape-on-cardiomyocyte-protection-via-connexin-43-regulation-under-hypoxia
#5
Chien-Cheng Chen, Chan-Yen Kuo, Rong-Fu Chen
Background: Cardiomyocyte under hypoxia cause cell death or damage is associated with heart failure. Gap junction, such as connexin 43 play a role in regulation of heart function under hypoxia. Caffeic acid phenethyl ester (CAPE) has been reported as an active component of propolis, has antioxidative, anti-inflammatory antiproliferative and antineoplastic biological properties. Aims: Connexin 43 appear to have a critical role in heart failure under hypoxia, there has been considerable interest in identifying the candidate component or compound to reduce cell death...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27643941/omega-3-fatty-acids-reduce-lipopolysaccharide-induced-abnormalities-in-expression-of-connexin-40-in-aorta-of-hereditary-hypertriglyceridemic-rats
#6
K Frimmel, R Sotníková, J Navarová, I Bernátová, J KriŽák, Z Haviarová, B Kura, J Slezák, Ľ Okruhlicová
Omega-3 fatty acids (omega3FA) are known to reduce hypertriglyceridemia- and inflammation-induced vascular wall diseases. However, mechanisms of their effects are not completely clear. We examined, whether 10-day omega3FA diet can reduce bacterial lipopolysaccharide-induced changes in expression of gap junction protein connexin40 (Cx40) in the aorta of hereditary hypertriglyceridemic (hHTG) rats. After administration of a single dose of lipopolysaccharide (LPS, 1 mg/kg, i.p.) to adult hHTG rats, animals were fed with omega3FA diet (30 mg/kg/day) for 10 days...
September 19, 2016: Physiological Research
https://www.readbyqxmd.com/read/27585976/systemic-inflammation-disrupts-oligodendrocyte-gap-junctions-and-induces-er-stress-in-a-model-of-cns-manifestations-of-x-linked-charcot-marie-tooth-disease
#7
Margarita Olympiou, Irene Sargiannidou, Kyriaki Markoullis, Christos Karaiskos, Alexia Kagiava, Styliana Kyriakoudi, Charles K Abrams, Kleopas A Kleopa
X-linked Charcot-Marie-Tooth disease (CMT1X) is a common form of inherited neuropathy resulting from different mutations affecting the gap junction (GJ) protein connexin32 (Cx32). A subset of CMT1X patients may additionally present with acute fulminant CNS dysfunction, typically triggered by conditions of systemic inflammation and metabolic stress. To clarify the underlying mechanisms of CNS phenotypes in CMT1X we studied a mouse model of systemic inflammation induced by lipopolysaccharide (LPS) injection to compare wild type (WT), connexin32 (Cx32) knockout (KO), and KO T55I mice expressing the T55I Cx32 mutation associated with CNS phenotypes...
2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27499271/reduction-of-c-kit-positive-cardiac-stem-cells-in-patients-with-atrial-fibrillation
#8
Daisuke Shinohara, Satoshi Matsushita, Taira Yamamoto, Hirotaka Inaba, Kenji Kuwaki, Akie Shimada, Atsushi Amano
BACKGROUND: We aimed to determine expression patterns of cardiac stem cells in the left atrium (LA) tissue from patients with atrial fibrillation. METHODS: LA appendages were obtained during open-heart surgery and processed for explant cell culture and tissue analysis (n=319). The total number of grown cells and c-kit positive cells were analyzed by flow cytometry after 4 weeks of culture. The remaining tissue was used for Masson's trichrome staining to determine the area of the fibrosis...
August 4, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27383147/role-of-myoendothelial-gap-junctions-in-the-regulation-of-human-coronary-artery-smooth-muscle-cell-differentiation-by-laminar-shear-stress
#9
Zongqi Zhang, Yizhu Chen, Tiantian Zhang, Lingyu Guo, Wenlong Yang, Junfeng Zhang, Changqian Wang
BACKGROUND/AIMS: Smooth muscle cells may dedifferentiate into the synthetic phenotype and promote atherosclerosis. Here, we explored the role of myoendothelial gap junctions in phenotypic switching of human coronary artery smooth muscle cells (HCASMCs) co-cultured with human coronary artery endothelial cells (HCAECs) exposed to shear stress. METHODS: HCASMCs and HCAECs were seeded on opposite sides of Transwell inserts, and HCAECs were exposed to laminar shear stress of 12 dyn/cm2 or 5 dyn/cm2...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27340645/detection-of-connexion-26-gene-gjb2-mutations-in-cases-of-congenital-non-syndromic-deafness
#10
Hansa Banjara, Varsha Mungutwar, Neha Swarnkar, Pradeep Patra
Hearing loss is most common form of genetic hearing disorder. Non-syndromic sensory neural autosomal recessive deafness (NSRD) is the most common form of genetic hearing loss. Mutations in GJB2 gene, which encodes the connexin 26 protein, are major cause of NSRD. The aim of this study is directed towards the mutations caused along the connexin 26 gene using blood samples from nonsyndromic deaf children. The study was conducted on 36 congenitally hearing impaired children who visited to our department with complains of hearing loss and reduced speech and whose age was <10 years with no other congenital anomaly...
June 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27323125/tiaogan-qingxin-granule-treatment-increases-myocardial-connexin-43-expression-in-a-rat-model-of-arrhythmia
#11
J H Yao, C H Qu, L Ma, X Z Chang
Myocardial ischemia-induced arrhythmia, especially ventricular arrhythmia, is the main reason for sudden cardiac death. Therefore, ischemic ventricular arrhythmia-targeted treatments are urgently needed. The mechanism of Tiaogan Qingxin Granule in premature ventricular beat (PVB) treatment was explored in arrhythmic rats pretreated with Tiaogan Qingxin Granule. Sprague-Dawley rats (N = 40) were randomly divided into 4 groups: sham-operated, arrhythmia model, Wenxin Granule, and Tiaogan Qingxin Granule. The ischemic arrhythmia model was established by ligating the left anterior descending coronary artery...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27281488/thermosensitive-and-highly-flexible-hydrogels-capable-of-stimulating-cardiac-differentiation-of-cardiosphere-derived-cells-under-static-and-dynamic-mechanical-training-conditions
#12
Zhenqing Li, Zhaobo Fan, Yanyi Xu, Hong Niu, Xiaoyun Xie, Zhenguo Liu, Jianjun Guan
Cardiac stem cell therapy has been considered as a promising strategy for heart tissue regeneration. Yet achieving cardiac differentiation after stem cell transplantation remains challenging. This compromises the efficacy of current stem cell therapy. Delivery of cells using matrices that stimulate the cardiac differentiation may improve the degree of cardiac differentiation in the heart tissue. In this report, we investigated whether elastic modulus of highly flexible poly(N-isopropylamide) (PNIPAAm)-based hydrogels can be modulated to stimulate the encapsulated cardiosphere derived cells (CDCs) to differentiate into cardiac lineage under static condition and dynamic stretching that mimics the heart beating condition...
June 29, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27230612/role-of-connexins-and-pannexins-during-ontogeny-regeneration-and-pathologies-of-bone
#13
Lilian I Plotkin, Dale W Laird, Joelle Amedee
Electron micrographs revealed the presence of gap junctions in osteoblastic cells over 40 years ago. These intercellular channels formed from connexins are present in bone forming osteoblasts, bone resorbing osteoclasts, and osteocytes (mature osteoblasts embedded in the mineralized bone matrix). More recently, genetic and pharmacologic studies revealed the role of connexins, and in particular Cx43, in the differentiation and function of all bone types. Furthermore, mutations in the gene encoding Cx43 were found to be causally linked to oculodentodigital dysplasia, a condition that results in an abnormal skeleton...
2016: BMC Cell Biology
https://www.readbyqxmd.com/read/27082714/early-and-extensive-spinal-white-matter-involvement-in-neuromyelitis-optica
#14
Shotaro Hayashida, Katsuhisa Masaki, Tomomi Yonekawa, Satoshi O Suzuki, Akio Hiwatashi, Takuya Matsushita, Mitsuru Watanabe, Ryo Yamasaki, Toshihiko Suenaga, Toru Iwaki, Hiroyuki Murai, Jun-Ichi Kira
OBJECTIVES: Studies of longitudinally extensive spinal cord lesions (LESCLs) in neuromyelitis optica (NMO) have focused on gray matter, where the relevant antigen, aquaporin-4 (AQP4), is abundant. Because spinal white matter pathology in NMO is not well characterized, we aimed to clarify spinal white matter pathology of LESCLs in NMO. METHODS: We analyzed 50 spinal cord lesions from eleven autopsied NMO/NMO spectrum disorder (NMOSD) cases. We also evaluated LESCLs with three or fewer spinal cord attacks by 3-tesla MRI in 15 AQP4 antibody-positive NMO/NMOSD patients and in 15 AQP4 antibody-negative multiple sclerosis (MS) patients...
April 15, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27051235/type-2-diabetes-induces-prolonged-p-wave-duration-without-left-atrial-enlargement
#15
Bin Li, Yilong Pan, Xiaodong Li
Prolonged P-wave duration has been observed in diabetes. However, the underlying mechanisms remain unclear. The aim of this study was to elucidate the possible mechanisms. A rat model of type 2 diabetes mellitus (T2DM) was used. P-wave durations were obtained using surface electrocardiography and sizes of the left atrium were determined using echocardiography. Cardiac inward rectifier K(+) currents (Ik1), Na(+) currents (INa), and action potentials were recorded from isolated left atrial myocytes using patch clamp techniques...
April 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27021518/prolongation-of-atrio-ventricular-node-conduction-in-a-rabbit-model-of-ischaemic-cardiomyopathy-role-of-fibrosis-and-connexin-remodelling
#16
Ashley M Nisbet, Patrizia Camelliti, Nicola L Walker, Francis L Burton, Stuart M Cobbe, Peter Kohl, Godfrey L Smith
Conduction abnormalities are frequently associated with cardiac disease, though the mechanisms underlying the commonly associated increases in PQ interval are not known. This study uses a chronic left ventricular (LV) apex myocardial infarction (MI) model in the rabbit to create significant left ventricular dysfunction (LVD) 8weeks post-MI. In vivo studies established that the PQ interval increases by approximately 7ms (10%) with no significant change in average heart rate. Optical mapping of isolated Langendorff perfused rabbit hearts recapitulated this result: time to earliest activation of the LV was increased by 14ms (16%) in the LVD group...
May 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/26993221/antiarrhythmic-effect-of-growth-factor-supplemented-cardiac-progenitor-cells-in-chronic-infarcted-heart
#17
Monia Savi, Leonardo Bocchi, Stefano Rossi, Caterina Frati, Gallia Graiani, Costanza Lagrasta, Michele Miragoli, Elisa Di Pasquale, Giuliano G Stirparo, Giuseppina Mastrototaro, Konrad Urbanek, Antonella De Angelis, Emilio Macchi, Donatella Stilli, Federico Quaini, Ezio Musso
c-Kit(pos) cardiac progenitor cells (CPCs) represent a successful approach in healing the infarcted heart and rescuing its mechanical function, but electrophysiological consequences are uncertain. CPC mobilization promoted by hepatocyte growth factor (HGF) and IGF-1 improved electrogenesis in myocardial infarction (MI). We hypothesized that locally delivered CPCs supplemented with HGF + IGF-1 (GFs) can concur in ameliorating electrical stability of the regenerated heart. Adult male Wistar rats (139 rats) with 4-wk-old MI or sham conditions were randomized to receive intramyocardial injection of GFs, CPCs, CPCs + GFs, or vehicle (V)...
June 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/26973973/aberrant-expression-of-connexin-isoforms-in-the-corpus-epididymis-of-the-adult-rat-by-exposure-to-estradiol-benzoate-or-flutamide-at-the-weaning-age
#18
Seong-Kyu Lee, Ki-Ho Lee
A proper development of the epididymis during the early postnatal development is required for successful fertility in the adult male. Direct cell-cell communication via connexin (Cx) molecules is a common way of cellular interactions to achieve normal development of a given tissue consisting of different cell types. The present research was attempted to determine the effect of exogenous exposure to estrogenic agonist or antiandrogen at the weaning age on expression of Cx isoforms in the adult corpus epididymis...
December 2015: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/26927369/-an-increase-in-the-ratio-of-peripheral-blood-cd4-cd8-t-lymphocytes-and-the-levels-of-connexin-40-and-inflammatory-factors-in-spontaneously-hypertensive-rats
#19
Ai Wang, Haichao Zhang, Liang Zhang, Xinzhi Li, Li Li, Junqiang Si, Ketao Ma
OBJECTIVE: To analyze the relationships of connexin 40 (Cx40) with peripheral blood CD4(+) and CD8(+) T lymphocyte subsets and inflammatory factors of spontaneously hypertensive (SH) rats. METHODS: Flow cytometry was used to detect CD4(+), CD8(+) lymphocytes and Cx40 expression on the cells in the peripheral blood of Wistar-Kyoto (WKy) rats and SH rats. ELISA was performed to test the levels of interleukin 2 (IL-2), interferon γ (IFN-γ), IL-4 and IL-6. RESULTS: Compared with WKy rats, the systolic blood pressure, the percentage of CD4(+) T lymphocytes, the expression of Cx40 on the surface of CD4(+) and CD8(+) T lymphocytes and the ratio of CD4(+)/CD8(+) in the peripheral blood of SH rats were significantly higher, with the exception of the percentage of CD8(+) lymphocytes which was lower...
February 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/26925136/deficiency-of-cyclase-associated-protein-2-promotes-arrhythmias-associated-with-connexin43-maldistribution-and-fibrosis
#20
Florian Stöckigt, Vivek Shahaji Peche, Markus Linhart, Georg Nickenig, Angelika Anna Noegel, Jan Wilko Schrickel
INTRODUCTION: Cyclase-associated protein 2 (CAP2) plays a major role in regulating the actin cytoskeleton. Since inactivation of CAP2 in a mouse model by a gene trap approach (Cap2 (gt/gt) ) results in cardiomyopathy and increased mortality, we hypothesized that CAP2 has a major impact on arrhythmias and electrophysiological parameters. MATERIAL AND METHODS: We performed long-term-ECG recordings in transgenic CAP2 deficient mice (C57BL/6) to detect spontaneous arrhythmias...
February 1, 2016: Archives of Medical Science: AMS
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