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https://www.readbyqxmd.com/read/28429502/involvement-of-erk1-2-in-cx43-depression-induced-by-macrophage-migration-inhibitory-factor-in-atrial-myocytes
#1
Xin Li, Fang Rao, Chun-Yu Deng, Wei Wei, Fang-Zhou Liu, Hui Yang, Zhao-Yu Wang, Su-Juan Kuang, Xiao-Yan Chen, Yu-Mei Xue, Shu-Lin Wu
Connexin 43 (Cx43) plays an important role in the pathogenesis of atrial fibrillation (AF). The present study sought to investigate the effect of macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, on Cx43 expression and activity and determine the intracellular signaling pathways. Cx43 protein and mRNA levels were assayed using immunofluorescence, real-time PCR, and western blot. We found that increased MIF and extracellular regulated protein kinases (ERK) expression was accompanied by a significant reduction in Cx43 protein expression in atrial tissues from patients with AF compared with those with sinus rhythm...
April 21, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28373150/involvement-of-autophagy-in-connexin-40-reduction-in-the-late-phase-of-traumatic-brain-injury-in-rats
#2
Wei Che, Yijun Guo, Wenjin Yang, Ping Zheng, Jinsong Zeng, Wusong Tong
Brain trauma can activate an attenuation of connexin gap junction that is implicated in neuronal injury, but the underlying cellular mechanisms remain incompletely understood. Here, we aimed to study whether autophagy, a stress-response process for recycling of intracellular proteins and organelles, is involved in the reduction of connexin 40 (Cx40) during the late phase of traumatic brain injury (TBI). In a rat model of TBI induced by controlled cortical impact (CCI), we found that Cx40 protein in the brain started to decline at post-surgery day 2 and the decrease continued for up to day 6...
April 1, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28350969/mechanisms-of-spontaneous-pacing-sa-nodal-cells-neonatal-cardiomyocytes-and-human-stem-cell-derived-cardiomyocytes
#3
Martin Morad, Xiaohua Zhang
The sino-atrial node is the primary site from which the mammalian heart is paced, but the mechanisms underlying the pacemaking still remain clouded. It is generally believed that the hyperpolarization-activated current I<sub><i>f</i></sub>, encoded by Hyperpolarization-activated cyclic nucleotide-gated (HCN) genes, contributes significantly to pacing, which in tandem with inward current generated by efflux of Ca<sup>2+</sup> via the Na<sup>+</sup>-Ca<sup>2+</sup> exchanger (NCX), resulting from the released Ca<sup>2+</sup>, mediates the diastolic depolarization...
March 28, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28260321/-hydroxyfasudi-attenuates-lipopolysaccharide-induced-endothelial-dysfunction-via-suppressing-the-expression-of-rho-associated-coiled-coil-protein-kinase-1-connexin-43-and-caveolin-1
#4
P F Zheng, X H Wu, W Huang, G T Ma, Q Bi
Objective: To investigate the effect and mechanism of hydroxyfasudi (HF), a specific Rho kinase inhibitor, on lipopolysaccharide(LPS)induced endothelial dysfunction. Methods: A total of 24 male Sprague Dawley rats were randomly divided into control group(n=6), HF group(n=6), LPS group(n=6) and LPS + HF group(n=6) with random number table method. There was no special treatment in control group. HF (30 mg/kg) was injected intraperitoneally in HF group. LPS (1 mg/kg) were injected intravenously in LPS group. In LPS+ HF group, HF (30 mg/kg) was injected intraperitoneally, followed by intravenous LPS injection (1 mg/kg) 30 minutes later...
February 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28259990/role-of-gap-junctions-in-the-contractile-response-to-agonists-in-the-mesenteric-resistance-artery-of-rats-with-acute-hypoxia
#5
Huan Liu, Xin-Zhi Li, Min Peng, Wei Ji, Lei Zhao, Li Li, Liang Zhang, Jun-Qiang Si, Ke-Tao Ma
Hypoxic exposure results in the vascular dysfunction and reduction of vasomotor responses and thus disrupts or reduces blood flow in the resistance arteries. Connexin (Cx)-mediated gap junctional intercellular communication (GJIC) serves a critical role in the regulation of vasomotor tone and the synchronized contraction of arteries, however whether the adverse effect of hypoxia on vasomotor responses in vascular smooth muscle layer of resistance arteries is involved in changes in the GJIC and the expression of Cx43 and Cx45 remains to be elucidated...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28250650/chronic-intake-of-green-propolis-negatively-affecting-the-rat-testis
#6
Grasiela Dias de Campos Severi-Aguiar, Suellen Josine Pinto, Cristina Capucho, Camila Andrea Oliveira, Maria Aparecida Diamante, Renata Barbieri, Fabrícia Souza Predes, Heidi Dolder
BACKGROUND: Human and animal evidence suggests that environmental toxicants may have an adverse impact on male reproductive health, reducing the population's reproductive output. Owing to the renewed attraction for natural products, some of them constitute effective alternatives to mitigate these effects. Propolis is a candidate for this use because of its intrinsic properties. In many situations, it improved the testicular damage and alleviated the toxic effects induced by environmental contaminant exposure...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28177659/effects-of-ferulic-acid-on-oxidative-stress-heat-shock-protein-70-connexin-43-and-monoamines-in-hippocampus-of-pentylenetetrazole-kindled-rats
#7
Abdelaziz M Hussein, Khalid M Abbas, Osama A Abulseoud, Elhussainy Mohamed Abouelez Elhussainy
The present study investigated the effects of ferulic acid on pentylenetetrazole (PTZ)-induced seizures, oxidative stress markers (malondialdhyde (MDA), catalase (CAT) and reduced glutathione (GSH)), connexin (Cx) 43, heat shock protein (Hsp) 70 and monoamines (serotonin (5HT) and norepinephrine (NE) levels in a rat model of PTZ-induced kindling. Sixty Sprague Dawley rats were divided into 5 equal groups, a) normal group, b) FA group: normal rats received FA at a dose of 40 mg/kg daily, c) PTZ group: rats received PTZ at a dose of 50 mg/kg i...
February 3, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28170287/intermediate-reprogramming-of-mouse-skin-fibroblasts-into-stem-like-cells-by-bone-morphogenetic-protein-4
#8
Seung-Eun Lee, Sang-Jun Uhm, Yeo-Jin Son, Yun-Gwi Park, Eun-Young Kim, Se-Pill Park
Specific transcription factors are sufficient to reprogram fully induced pluripotent stem cells or other types of cells. These findings raise the question of whether chemical molecules or proteins can replace transcription factors to alter the defined cell fate. In this study, we treated mouse skin fibroblasts (MSFs) with bone morphogenetic protein 4 (BMP4) and examined intermediate reprogramming of MSFs into stem-like cells. Putative epidermal stem cells isolated from the ventral skin epidermis of an adult mouse were used to confirm the reprogramming activity of BMP4, which increased the proliferation of these cells...
April 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28034749/functional-consequences-of-co-expressing-connexin40-or-connexin45-with-connexin43-on-intercellular-electrical-coupling
#9
Neil M Thomas, Rosaire Gray, Christopher H Fry, Thomas Desplantez, Nicholas S Peters, Nicholas J Severs, Kenneth T Macleod, Emmanuel Dupont
The functional characteristics of the co-expression of connexin43, connexin40, and connexin45 proteins in human myocardium are thought to play an important role in governing normal propagation of the cardiac electrical impulse and in generating the myocardial substrate for some arrhythmias and conduction disturbances. A rat liver epithelial cell line, that endogenously expresses connexin43, was used to induce also expression of connexin40 or connexin45 after stable transfection using an inducible ecdysone system...
January 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28033238/congenital-cytomegalovirus-infection-and-permanent-hearing-loss-in-rural-north-indian-children
#10
Lalit Dar, Divya Namdeo, Pankaj Kumar, Alok Thakar, Shashi Kant, Sanjay Rai, Pawan K Singh, Madhulika Kabra, Karen B Fowler, Suresh B Boppana
BACKGROUND: Congenital cytomegalovirus infection (cCMV) is a leading non-genetic cause of permanent congenital or early-onset hearing loss (PCEHL). Although cCMV rates are high despite near-universal seroimmunity, the contribution of cCMV to PCEHL in the developing world is unclear. METHODS: Neonates at a rural north Indian hospital were screened for cCMV by saliva PCR and hearing by distortion product otoacoustic emission (DPOAE) testing. CMV positive infants and those not passing newborn hearing screening (NHS) were evaluated by auditory brainstem response to confirm PCEHL...
December 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27871290/heterozygous-connexin-50-mutation-affects-metabolic-syndrome-attributes-in-spontaneously-hypertensive-rat
#11
Ondřej Šeda, Drahomíra Křenová, Olena Oliyarnyk, Lucie Šedová, Michaela Krupková, František Liška, Blanka Chylíková, Ludmila Kazdová, Vladimír Křen
BACKGROUND: Several members of connexin family of transmembrane proteins were previously implicated in distinct metabolic conditions. In this study we aimed to determine the effects of complete and heterozygous form of connexin50 gene (Gja8) mutation L7Q on metabolic profile and oxidative stress parameters in spontaneously hypertensive inbred rat strain (SHR). METHODS: Adult, standard chow-fed male rats of SHR, heterozygous SHR-Dca+/- and SHR-Dca-/- coisogenic strains were used...
November 21, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27843504/relationship-between-patients-with-clinical-auditory-neuropathy-spectrum-disorder-and-mutations-in-gjb2-gene
#12
Guilherme M de Carvalho, Priscila Z Ramos, Arthur M Castilho, Alexandre C Guimarães, Edi L Sartorato
The auditory neuropathy is a condition which there is a dyssynchrony in the nerve conduction of the auditory nerve fibers. There is no evidence about the relationship between patients with clinical auditory neuropathy spectrum disorder and mutations in GJB2 gene. There are only two studies about this topic in the medical literature. Connexin 26 (GJB2 gene) mutations are common causes of genetic deafness in many populations and we also being reported in subjects with auditory neuropathy. OBJECTIVE: To analyze the pattern of clinical relationship between patients with clinical diagnosis with auditory neuropathy spectrum disorder and GJB2 gene...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27826129/genotypic-and-phenotypic-predictors-of-complete-heart-block-and-recovery-of-conduction-after-surgical-repair-of-congenital-heart-disease
#13
Laura E Murray, Andrew H Smith, English C Flack, Kim Crum, Jill Owen, Prince J Kannankeril
BACKGROUND: Complete heart block (CHB) is a major complication that occurs after congenital heart surgery. We hypothesized that genetic and clinical factors are associated with the development of postoperative CHB and recovery of atrioventricular (AV) conduction. OBJECTIVE: The purpose of this study was to identify predictors of CHB and recovery after congenital heart surgery. METHODS: Patients undergoing congenital heart surgery at our institution from September 2007 through June 2015 were prospectively enrolled in a parent study of postoperative arrhythmias...
March 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27813566/association-between-44g-a-and-71a-g-polymorphisms-in-the-connexin-40-gene-and-atrial-fibrillation-in-uyghur-and-han-populations-in-xinjiang-china
#14
J Hailati, Y C Yang, L Zhang, P Y He, M Baikeyi, W Muhuyati, Z Q Liu
We aimed to elucidate the association between connexin 40 (Cx40) genetic polymorphisms and atrial fibrillation (AF) in a Chinese population in Xinjiang comprising Uyghur and Han individuals. We enrolled 275 Uyghur and 305 age- and gender-matched Han subjects, and used polymerase chain reaction to detect single nucleotide polymorphisms (SNPs; -44G/A and +71A/G) in the gene encoding Cx40. A mutation screening was performed by direct sequencing and calculation of genotype and allele frequencies among AF patients and control subjects to determine the relationship between these variants and this condition in Uyghur and Han populations...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27766024/role-of-cape-on-cardiomyocyte-protection-via-connexin-43-regulation-under-hypoxia
#15
Chien-Cheng Chen, Chan-Yen Kuo, Rong-Fu Chen
Background: Cardiomyocyte under hypoxia cause cell death or damage is associated with heart failure. Gap junction, such as connexin 43 play a role in regulation of heart function under hypoxia. Caffeic acid phenethyl ester (CAPE) has been reported as an active component of propolis, has antioxidative, anti-inflammatory antiproliferative and antineoplastic biological properties. Aims: Connexin 43 appear to have a critical role in heart failure under hypoxia, there has been considerable interest in identifying the candidate component or compound to reduce cell death...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27643941/omega-3-fatty-acids-reduce-lipopolysaccharide-induced-abnormalities-in-expression-of-connexin-40-in-aorta-of-hereditary-hypertriglyceridemic-rats
#16
K Frimmel, R Sotníková, J Navarová, I Bernátová, J KriŽák, Z Haviarová, B Kura, J Slezák, Ľ Okruhlicová
Omega-3 fatty acids (omega3FA) are known to reduce hypertriglyceridemia- and inflammation-induced vascular wall diseases. However, mechanisms of their effects are not completely clear. We examined, whether 10-day omega3FA diet can reduce bacterial lipopolysaccharide-induced changes in expression of gap junction protein connexin40 (Cx40) in the aorta of hereditary hypertriglyceridemic (hHTG) rats. After administration of a single dose of lipopolysaccharide (LPS, 1 mg/kg, i.p.) to adult hHTG rats, animals were fed with omega3FA diet (30 mg/kg/day) for 10 days...
September 19, 2016: Physiological Research
https://www.readbyqxmd.com/read/27585976/systemic-inflammation-disrupts-oligodendrocyte-gap-junctions-and-induces-er-stress-in-a-model-of-cns-manifestations-of-x-linked-charcot-marie-tooth-disease
#17
Margarita Olympiou, Irene Sargiannidou, Kyriaki Markoullis, Christos Karaiskos, Alexia Kagiava, Styliana Kyriakoudi, Charles K Abrams, Kleopas A Kleopa
X-linked Charcot-Marie-Tooth disease (CMT1X) is a common form of inherited neuropathy resulting from different mutations affecting the gap junction (GJ) protein connexin32 (Cx32). A subset of CMT1X patients may additionally present with acute fulminant CNS dysfunction, typically triggered by conditions of systemic inflammation and metabolic stress. To clarify the underlying mechanisms of CNS phenotypes in CMT1X we studied a mouse model of systemic inflammation induced by lipopolysaccharide (LPS) injection to compare wild type (WT), connexin32 (Cx32) knockout (KO), and KO T55I mice expressing the T55I Cx32 mutation associated with CNS phenotypes...
2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27499271/reduction-of-c-kit-positive-cardiac-stem-cells-in-patients-with-atrial-fibrillation
#18
Daisuke Shinohara, Satoshi Matsushita, Taira Yamamoto, Hirotaka Inaba, Kenji Kuwaki, Akie Shimada, Atsushi Amano
BACKGROUND: We aimed to determine expression patterns of cardiac stem cells in the left atrium (LA) tissue from patients with atrial fibrillation. METHODS: LA appendages were obtained during open-heart surgery and processed for explant cell culture and tissue analysis (n=319). The total number of grown cells and c-kit positive cells were analyzed by flow cytometry after 4 weeks of culture. The remaining tissue was used for Masson's trichrome staining to determine the area of the fibrosis...
May 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/27383147/role-of-myoendothelial-gap-junctions-in-the-regulation-of-human-coronary-artery-smooth-muscle-cell-differentiation-by-laminar-shear-stress
#19
Zongqi Zhang, Yizhu Chen, Tiantian Zhang, Lingyu Guo, Wenlong Yang, Junfeng Zhang, Changqian Wang
BACKGROUND/AIMS: Smooth muscle cells may dedifferentiate into the synthetic phenotype and promote atherosclerosis. Here, we explored the role of myoendothelial gap junctions in phenotypic switching of human coronary artery smooth muscle cells (HCASMCs) co-cultured with human coronary artery endothelial cells (HCAECs) exposed to shear stress. METHODS: HCASMCs and HCAECs were seeded on opposite sides of Transwell inserts, and HCAECs were exposed to laminar shear stress of 12 dyn/cm2 or 5 dyn/cm2...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27340645/detection-of-connexion-26-gene-gjb2-mutations-in-cases-of-congenital-non-syndromic-deafness
#20
Hansa Banjara, Varsha Mungutwar, Neha Swarnkar, Pradeep Patra
Hearing loss is most common form of genetic hearing disorder. Non-syndromic sensory neural autosomal recessive deafness (NSRD) is the most common form of genetic hearing loss. Mutations in GJB2 gene, which encodes the connexin 26 protein, are major cause of NSRD. The aim of this study is directed towards the mutations caused along the connexin 26 gene using blood samples from nonsyndromic deaf children. The study was conducted on 36 congenitally hearing impaired children who visited to our department with complains of hearing loss and reduced speech and whose age was <10 years with no other congenital anomaly...
June 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
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