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https://www.readbyqxmd.com/read/29783020/immune-modulation-of-a-novel-lipid-soluble-extract-of-pinellia-pedatisecta-schott-in-the-tumor-microenvironment-of-an-hpv-tumor-burdened-mouse-model
#1
Haixia Huang, Mingxing Zhang, Meng Zhang, Jing Peng, Guiling Li, Congjian Xu, Suiqi Gui
ETHNOPHARMACOLOGICAL RELEVANCE: Pinellia pedatisecta Schott extract (PE), a traditional Chinese medicine, has been used to reduce swelling, dry dampness and suppress cervical tumors. AIMS: To evaluate the roles of PE in the regulation of anti-tumor effects and the cellular immune response in the tumor microenvironment. METHODS: The immune microenvironment of HPV+ TC-1 tumors was examined by immunohistochemistry, real-time PCR and flow cytometry...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29778312/biomarker-signatures-of-sickle-cell-disease-severity
#2
Mengtian Du, Sarah Van Ness, Victor Gordeuk, Sayed M Nouraie, Sergei Nekhai, Mark Gladwin, Martin H Steinberg, Paola Sebastiani
Identifying sickle cell disease patients at high risk of complications could lead to personalized treatment and better prognosis but despite many advances prediction of the clinical course of these patients remains elusive. We propose a system-type approach to discover profiles of multiple, common biomarkers that correlate with morbidity and mortality in sickle cell disease. We used cluster analysis to discover 17 signatures of 17 common circulating biomarkers in 2320 participants of the Cooperative Study of Sickle Cell Disease, and evaluated the association of these signatures with risk for stroke, pain, leg ulceration, acute chest syndrome, avascular necrosis, seizure, death, and trend of fetal hemoglobin and hemolysis using longitudinally collected data...
May 16, 2018: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/29775801/narrative-review-on-the-effect-of-shockwave-treatment-for-management-of-upper-and-lower-extremity-musculoskeletal-conditions
#3
REVIEW
Julia M Reilly, Eric Bluman, Adam S Tenforde
Extracorporeal shockwave therapy (ESWT) is a technology that was first introduced into clinical practice in 1982 for urological conditions. Subsequent clinical applications in musculoskeletal conditions have been described in treatment of plantar fasciopathy, both upper and lower extremity tendinopathies, greater trochanteric pain syndrome, medial tibial stress syndrome, management of non-union fractures, and joint disease including avascular necrosis (AVN). The aim of this review is to summarize the current understanding of treatment of musculoskeletal conditions with ESWT, accounting for differences in treatment protocol and energy levels...
May 15, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29765616/quantifying-the-burden-of-steroid-related-damage-in-sle-in-the-hopkins-lupus-cohort
#4
Julie E Davidson, Qinggong Fu, Sapna Rao, Laurence S Magder, Michelle Petri
Objective: Corticosteroids are a mainstay of SLE treatment; however, cumulative steroid exposure may lead to organ damage. This study aimed to quantify the risk of new diabetes, hypertension, cataracts, osteoporosis and avascular necrosis that is attributable to cumulative corticosteroid exposure in SLE. Methods: Using data from the Hopkins Lupus Cohort, a longitudinal study of lupus activity, organ damage and quality of life in patients with SLE, five matched case-control analyses nested within a prospectively enrolled SLE cohort were performed...
2018: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29752504/duration-of-immobilization-after-developmental-dysplasia-of-the-hip-and-open-reduction-surgery
#5
Khaled Emara, Mohamed Ahmed Al Kersh, Fahad Abdulazeez Hayyawi
BACKGROUND: There is no consensus about the duration of post-operative immobilization in the treatment of DDH (developmental dysplasia of hip). Our aim in this study is to compare between two post-operative immobilization protocols for patients undergoing open reduction. MATERIALS AND METHODS: Thirty-eight hips in 32 patients assigned to group A were immobilized in hip spica for four weeks followed by abduction brace application which was gradually weaned through the periods of several months and 29 hips in 24 patients assigned to group B immobilized in hip spica for 12 weeks without further bracing...
May 11, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29750297/col2a1-mutation-c-3508g-a-leads-to-avascular-necrosis-of-the-femoral-head-in-a-chinese-family-a-case-report
#6
Fang Liu, Zhizheng Xiong, Qi Liu, Jinxi Hu, Wenhua Li, Na Zhang
Avascular necrosis of the femoral head (ANFH) is a consequence of ischemia. Although the majority of cases of ANFH are sporadic, certain familial cases of ANFH have been reported to be associated with collagen type II α1 chain (COL2A1) mutations, which lead to COL2A1 gene dysfunction. The structure of secreted type II collagen contains a core area with a triple helical glycine (Gly)‑X‑Y domain, and the replacement of Gly in this region as a result of COL2A1 mutations may damage the structure of type II collagen...
May 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29750162/screening-of-serum-protein-markers-for-avascular-osteonecrosis-of-femoral-head-differentially-expressed-after-treatment-with-yuanshi-shengmai-chenggu-tablets
#7
Peng Deng, Jianchun Zeng, Jie Li, Wenjun Feng, Jinlun Chen, Yirong Zeng
Avascular necrosis of the femoral head (ANFH) is an a frequently occurring orthopaedic disease with high morbidity. Traditional Chinese Medicine (TCM) Yuanshi Shengmai Chenggu Tablet is a valid prescription for treating steroid-induced femoral head necrosis. However, there are rare investigations about the serum protein marker expression after the acting of drugs on hormone and TCM. In the present study, we aimed to systematically discover and validate the serum biomarkers expression difference in patients with steroid-induced avascular necrosis of femoral head (SANFH) after taking Yuanshi Shengmai Chenggu Tablets (SANFH-TCM), so as to reveal the action mechanism of TCM from the molecular level by using isobaric tags for relative and absolute quantification (iTRAQ) with multiple reaction monitoring quantification...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29735376/operative-versus-nonoperative-treatment-of-proximal-humeral-fractures-a-systematic-review-meta-analysis-and-comparison-of-observational-studies-and-randomized-controlled-trials
#8
REVIEW
Reinier B Beks, Yassine Ochen, Herman Frima, Diederik P J Smeeing, Olivier van der Meijden, Tim K Timmers, Detlef van der Velde, Mark van Heijl, Luke P H Leenen, Rolf H H Groenwold, R Marijn Houwert
BACKGROUND: There is no consensus on the choice of treatment for displaced proximal humeral fractures in older patients (aged > 65 years). The aims of this systematic review and meta-analysis were (1) to compare operative with nonoperative management of displaced proximal humeral fractures and (2) to compare effect estimates obtained from randomized controlled trials (RCTs) and observational studies. METHODS: The databases of MEDLINE, Embase, CENTRAL (Cochrane Central Register of Controlled Trials), and CINAHL (Cumulative Index to Nursing and Allied Health Literature) were searched on September 5, 2017, for studies comparing operative versus nonoperative treatment of proximal humeral fractures; both RCTs and observational studies were included...
May 4, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29729342/safflower-carthamus-tinctorius-l-polysaccharide-attenuates-cellular-apoptosis-in-steroid-induced-avascular-necrosis-of-femoral-head-by-targeting-caspase-3-dependent-signaling-pathway
#9
Daping Cui, Dewei Zhao, Benjie Wang, Baoyi Liu, Lei Yang, Hui Xie, Zihua Wang, Liangliang Cheng, Xing Qiu, Zhijie Ma, Mingyang Yu, Di Wu, Hao Long
The present study aimed to investigate the effects of a purified polysaccharide (SPS) from the safflower in a cellular model of steroid-associated necrosis of the femoral head (SANFH), which was established in primary murine osteoblasts suffering dexamethasone pretreatment. After treatment with SPS (25, 50 and 100 μg/ml), the degree of necrosis induced by dexamethasone was significantly reduced in osteoblasts as evidenced by an increase of cell viability and a decrease of apoptosis in osteoblasts. Furthermore, pretreatment with SPS (25, 50 and 100 μg/ml) significantly attenuated the activation of caspase-3 and cleavage of PARP relative to the model control cells...
May 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29727407/three-dimensional-mri-analysis-of-femoral-head-remodeling-after-reduction-in-patients-with-developmental-dysplasia-of-the-hip
#10
Yuta Tsukagoshi, Hiroshi Kamada, Makoto Kamegaya, Ryoko Takeuchi, Shogo Nakagawa, Yohei Tomaru, Kenta Tanaka, Mio Onishi, Tomofumi Nishino, Masashi Yamazaki
BACKGROUND: Previous reports on patients with developmental dysplasia of the hip (DDH) showed that the prereduced femoral head was notably smaller and more nonspherical than the intact head, with growth failure observed at the proximal posteromedial area. We evaluated the shape of the femoral head cartilage in patients with DDH before and after reduction, with size and sphericity assessed using 3-dimensional (3D) magnetic resonance imaging (MRI). METHODS: We studied 10 patients with unilateral DDH (all female) who underwent closed reduction...
May 2, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29716513/developmental-dysplasia-of-the-hip-addressing-evidence-gaps-with-a-multicentre-prospective-international-study
#11
Emily K Schaeffer, Ihdi Study Group, Kishore Mulpuri
There is a lack of high quality evidence available to guide clinical practice in the treatment and management of developmental dysplasia of the hip (DDH). Evidence has been limited by persistent confusion on diagnostic and classification terminology, variability in surgeon decision making and a reliance on single centre, retrospective studies with small patient numbers. To address gaps in knowledge regarding screening, diagnosis and management of DDH, the International Hip Dysplasia Institute began a multicentre, international prospective study on infants with hips dislocated at rest...
May 7, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29715363/hip-joint-contact-pressure-distribution-during-pavlik-harness-treatment-of-an-infant-hip-a-patient-specific-finite-element-model
#12
Behzad Vafaeian, Samer Adeeb, Marwan El-Rich, Dornoosh Zonoobi, Abhilash R Hareendranathan, Jacob L Jaremko
Developmental dysplasia of the hip (DDH) in infants under 6 months of age is typically treated by the Pavlik harness (PH). During successful PH treatment, a subluxed/dislocated hip is spontaneously reduced into the acetabulum, and DDH undergoes self-correction. PH treatment may fail due to avascular necrosis (AVN) of the femoral head. An improved understanding of mechanical factors accounting for the success/failure of PH treatment may arise from investigating articular cartilage contact pressure (CCP) within a hip during treatment...
July 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29703458/operatively-treated-talus-fractures-complications-and-survivorship-in-a-large-patient-sample
#13
Michael A Stone, Russell R Flato, William Pannell, Jeremiah R Cohen, Jeffrey C Wang, Geoffrey S Marecek
Talus fractures are relatively uncommon; however, the sequelae of talus fractures can cause significant morbidity. Although avascular necrosis has been a consistently reported complication, the reported rates of subsequent arthrodesis have varied widely. The purpose of the present study was to report the complications in a large patient sample of operatively treated talus fractures and to describe the survivorship of open reduction internal fixation (ORIF) of the talus. Patients undergoing talus ORIF for closed or open fractures from 2007 to 2011 were identified in the United Healthcare System database by International Classification of Diseases, 9th revision, code 825...
April 24, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29698303/closed-reduction-osteotomy-and-fibular-graft-are-effective-in-treating-pediatric-femoral-neck-pseudarthrosis-after-infection
#14
Rajesh Kumar Kanojia, Sumit Gupta, Ajay Kumar, Bachha Kanakeya Reddy
BACKGROUND: When treatment of acute septic arthritis of the hip is delayed, severe sequelae can occur. This may take the form of coxa breva, vara, or valga. Pseudoarthrosis of the femoral neck is a rare complication with only a few studies to guide treatment. QUESTION/PURPOSES: In a small series of patients with pseudarthrosis of the femoral neck after acute septic arthritis, we wanted to determine (1) whether femoral neck union can be achieved using a variety of surgical approaches; (2) whether these patients satisfied criteria outlined by Hunka and Choi, defined as a stable hip, a flexion arc ≥ 70° and no fixed adduction or abduction contractures, fixed flexion deformity not more than 20°, pain relief, and restoration of activities of daily living after surgery; and (3) any treatment-related complications if observed...
April 23, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29691171/risk-adjustment-is-necessary-in-medicare-bundled-payment-models-for-total-hip-and-knee-arthroplasty
#15
P Maxwell Courtney, Daniel D Bohl, Edmund C Lau, Kevin L Ong, Joshua J Jacobs, Craig J Della Valle
BACKGROUND: Concerns exist that high-risk patients in alternative payment models may face difficulties with access to care without proper risk adjustment. The purpose of this study is to identify the effect of medical and orthopedic specific risk factors on the cost of a 90-day episode of care following total hip (THA) and knee arthroplasty (TKA). METHODS: We queried the Medicare 5% Limited Data Set for all patients undergoing primary THA and TKA from 2010 to 2014...
March 17, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29687874/effects-of-platelet-rich-plasma-on-angiogenesis-and-osteogenesis-associated-factors-in-rabbits-with-avascular-necrosis-of-the-femoral-head
#16
X-L Zhang, K-Q Shi, P-T Jia, L-H Jiang, Y-H Liu, X Chen, Z-Y Zhou, Y-X Li, L-S Wang
OBJECTIVE: Platelet-rich plasma (PRP) contains various growth factors and cytokines that can enhance the recovery of the damaged tissues. The present study aimed to examine the effects of PRP on the recovery of avascular necrosis of the femoral head (ANFH), and to provide novel insights into the clinical treatment of this disease. MATERIALS AND METHODS: A total of 24 New Zealand white rabbits were randomly divided into the normal control group, ANFH model and PRP-treated groups (n =1 2 each)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687316/bernese-type-triple-pelvic-osteotomy-through-a-single-incision-in-children-over-five-years-a-retrospective-study-of-twenty-eight-cases
#17
YiQiang Li, HongWen Xu, Theddy Slongo, QingHe Zhou, Yuanzhong Liu, WeiDong Chen, JingChun Li, Federico Canavese
INTRODUCTION: Bernese-type triple pelvic osteotomy (BTPO) combines periacetabular and triple innominate osteotomy techniques. However, studies that evaluate the clinical and radiographic outcomes of BTPO are scarce. The aim of this study is to report on the clinical and radiographic outcomes of ambulatory children with developmental dysplasia of the hip (DDH) or Legg-Calvé-Perthes disease (LCPD) managed with BTPO that were older than five years of age at the time of surgery. MATERIALS AND METHODS: We retrospectively reviewed the records of 27 consecutive patients with DDH or LCPD (mean age 7...
April 23, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29686621/pravastatin-protects-against-avascular-necrosis-of-femoral-head-via-autophagy
#18
Yun Liao, Ping Zhang, Bo Yuan, Ling Li, Shisan Bao
Autophagy serves as a stress response and may contribute to the pathogenesis of avascular necrosis of the femoral head induced by steroids. Statins promote angiogenesis and ameliorate endothelial functions through apoptosis inhibition and necrosis of endothelial progenitor cells, however the process used by statins to modulate autophagy in avascular necrosis of the femoral head remains unclear. This manuscript determines whether pravastatin protects against dexamethasone-induced avascular necrosis of the femoral head by activating endothelial progenitor cell autophagy...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29683475/pharmacological-interventions-for-the-prevention-of-insufficiency-fractures-and-avascular-necrosis-associated-with-pelvic-radiotherapy-in-adults
#19
REVIEW
Qurrat U van den Blink, Kate Garcez, Caroline C Henson, Susan E Davidson, Claire E Higham
BACKGROUND: Pelvic radiotherapy is a treatment delivered to an estimated 150,000 to 300,000 people annually across high-income countries. Fractures due to normal stresses on weakened bone due to radiotherapy are termed insufficiency fractures. Pelvic radiotherapy-related interruption of the blood supply to the hip is termed avascular necrosis and is another recognised complication. The reported incidences of insufficiency fractures are 2.7% to 89% and risk of developing avascular necrosis is 0...
April 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29681819/avascular-necrosis-of-bone-following-chemotherapy-in-cancer-patients-with-coagulopathy-report-of-two-cases
#20
Hui-Ching Hsu, Tzu-Yao Liao, Dave Wei-Chih Chen, Yu-Hsiang Juan, Chuang-Chi Liaw
We report 2 cases of patients with solid tumors and coagulopathy who experienced avascular necrosis (AVN) of the bone following chemotherapy. Both cases exhibited nontraumatic bilateral AVN of the femoral heads, and one also showed bilateral AVN of the humeral heads. One case had multiple thromboembolic complications, including pulmonary obstructive syndrome and paraneoplastic pain. The other showed multiple paraneoplastic syndromes, with hypercalcemia and thrombocytosis. Groin pain and claudication of the lower extremities developed and persisted...
January 2018: Case Reports in Oncology
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