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Multidrug resistant organism

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https://www.readbyqxmd.com/read/29240664/%C3%AE-pyrone-polyketides-from-streptomyces-ambofaciens-bi0048-an-endophytic-actinobacterial-strain-isolated-from-the-red-alga-laurencia-glandulifera
#1
Enikő Rab, Dimitrios Kekos, Vassilios Roussis, Efstathia Ioannou
Four new (1-4) and six previously reported (5-10) α-pyrone polyketides, along with benzoic acid, hydrocinnamic acid, and (E)-cinnamic acid, were isolated from the organic extract resulting from the cultivation of the algicolous strain Streptomyces ambofaciens BI0048, which in turn was isolated from the inner tissues of the red alga Laurencia glandulifera. The structure elucidation of the isolated natural products was based on extensive analysis of their spectroscopic data (NMR, MS, UV, IR). Compounds 1-10 were evaluated for their antibacterial and cytotoxic activities against two multidrug-resistant strains of Staphylococcus aureus and one strain of Escherichia coli, as well as two human cancer cell lines...
December 14, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29234805/contact-precautions-for-multidrug-resistant-organisms-reply
#2
LETTER
Daniel J Morgan, Richard P Wenzel, Gonzalo Bearman
No abstract text is available yet for this article.
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29234802/contact-precautions-for-multidrug-resistant-organisms
#3
LETTER
Lance R Peterson
No abstract text is available yet for this article.
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29234313/food-grade-pimenta-leaf-essential-oil-reduces-the-attachment-of-salmonella-enterica-heidelberg-2011-ground-turkey-outbreak-isolate-on-to-turkey-skin
#4
Divek V T Nair, Anup Kollanoor Johny
Salmonella attached to the poultry skin is a major source of carcass contamination during processing. Once attached to the poultry skin, it is difficult to detach and inactivate Salmonella by commonly used antimicrobial agents since the pathogen is entrapped deeply in the feather follicles and the crevices on the skin. Essential oils could be natural, safe, and effective alternatives to synthetic antimicrobial agents during commercial and organic processing setup. The present study evaluated the efficacy of pimenta (Pimenta officinalis Lindl...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29229108/infection-control-genetic-assessment-of-drug-resistance-and-drug-susceptibility-testing-in-the-current-management-of-multidrug-extensively-resistant-tuberculosis-m-xdr-tb-in-europe-a-tuberculosis-network-european-trialsgroup-tbnet-study
#5
Graham H Bothamley, Christoph Lange
AIM: Europe has the highest documented caseload and greatest increase in multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) of all World Health Organization (WHO) regions. This survey examines how recommendations for M/XDR-TB management are being implemented. METHODS: TBNET is a pan-European clinical research collaboration for tuberculosis. An email survey of TBNET members collected data in relation to infection control, access to molecular tests and basic microbiology with drug sensitivity testing...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29229015/risk-factors-for-acquisition-of-multidrug-resistant-escherichia-coli-and-development-of-community-acquired-urinary-tract-infections
#6
U V Ukah, M Glass, B Avery, D Daignault, M R Mulvey, R J Reid-Smith, E J Parmley, A Portt, P Boerlin, A R Manges
We examined risk factors associated with the intestinal acquisition of antimicrobial-resistant extraintestinal pathogenic Escherichia coli (ExPEC) and development of community-acquired urinary tract infection (UTI) in a case-control study of young women across Canada. A total of 399 women were recruited; 164 women had a UTI caused by E. coli resistant to ⩾1 antimicrobial classes and 98 had a UTI caused by E. coli resistant to ⩾3 antimicrobial classes. After adjustment for age, student health service (region of Canada) and either prior antibiotic use or UTI history, consumption of processed or ground chicken, cooked or raw shellfish, street foods and any organic fruit; as well as, contact with chickens, dogs and pet treats; and travel to Asia, were associated with an increased risk of UTI caused by antimicrobial resistant E...
December 12, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29220754/association-of-high-mortality-with-extended-spectrum-%C3%AE-lactamase-esbl-positive-cultures-in-community-acquired-infections
#7
Sumit Ray, Dimple Anand, Sankalp Purwar, Arijit Samanta, Kaustubh V Upadhye, Prasoon Gupta, Debashis Dhar
PURPOSE: Infections due to multidrug resistant organisms have become a serious health concern worldwide. The present study was conducted to investigate the spectrum of microbial resistance pattern in the community and their effects on mortality. METHODS: A retrospective review and analysis of prospectively collected data was done of all patients admitted with diagnosis of sepsis in two tertiary care ICU's for a period of two years. Demographics, culture positivity, microbial spectrum, resistance pattern and outcome data were collected...
October 31, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29219878/community-based-management-of-multiple-drug-resistant-tuberculosis-in-a-tertiary-hospital-in-tanzania-a-best-practice-implementation-project
#8
Isaya Jelly, Micah D J Peters
BACKGROUND: The World Health Organization (WHO) has prioritized collaboration with communities in its 2016 "End TB" implementation strategy. Acknowledging the difficulties that some communities face in gaining access to health facilities due to barriers such as stigma, discrimination, healthcare expenditure, transport and income loss, partnering with communities in the roll-out of community-based TB management activities is vital. AIM: The aim of this project was to make a contribution to promoting evidence-based practice with regards to the community-based management of multidrug-resistant tuberculosis (MDR-TB) at Kibong'oto National Infectious Disease Hospital, Tanzania, and thereby supporting improvements in patient outcomes and resource utilization...
December 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29217187/epidemiologic-surveillance-of-multidrug-resistant-bacteria-in-a-teaching-hospital-a-3-year-experience
#9
Mirian Nicéa Zarpellon, Giselle Fukita Viana, Cecília Saori Mitsugui, Bruno Buranello Costa, Nathalie Kira Tamura, Elisabeth Eyko Aoki, Cesar Helbel, Sheila Alexandra Belini Nishiyama, Silvia Maria Dos Santos Saalfeld, Maria Cristina Bronharo Tognim
BACKGROUND: The objective of this prospective study was to verify the effectiveness of a multidisciplinary surveillance program that was implemented in a teaching hospital in southern Brazil, to prevent and control the spread of multidrug-resistant organisms. METHODS: The program implemented involved establishment of prevention guidelines, hand-hygiene promotion, isolation of patients colonized or infected by such organisms, enforced contact precautions, and terminal cleaning and disinfection of isolation rooms...
December 4, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29216824/use-of-a-mixed-culture-strategy-to-isolate-halophilic-bacteria-with-antibacterial-and-cytotoxic-activity-from-the-manaure-solar-saltern-in-colombia
#10
Natalia Conde-Martínez, Alejandro Acosta-González, Luis E Díaz, Edisson Tello
BACKGROUND: Water evaporation in solar salterns creates salinity gradients that promote the adaptation of microbial species to different salinities. This competitive habitat challenges the metabolic capabilities of microorganisms and promotes alterations in their production of secondary metabolites. Thus, solar salterns are a potentially important source of new natural products. In Colombia, the most important and representative solar saltern is located in Manaure (La Guajira) in the north of Colombia...
December 8, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29205871/pharmacogenetic-analysis-of-the-model-based-pharmacokinetics-of-five-anti-hiv-drugs-how-does-this-influence-the-effect-of-aging
#11
Jingxian Chen, Farida S Akhtari, Michael J Wagner, Oscar Suzuki, Tim Wiltshire, Alison A Motsinger-Reif, Julie B Dumond
Analysis of aging and pharmacogenetics (PGx) on antiretroviral pharmacokinetics (PKs) could inform precision dosing for older human HIV-infected patients. Seventy-four participants receiving either atazanavir/ritonavir (ATV/RTV) or efavirenz (EFV) with tenofovir/emtricitabine (TFV/FTC) provided PK and PGx information. Aging-PGx-PK association and interaction analyses were conducted using one-way analysis of variance (ANOVA), multiple linear regression, and Random Forest ensemble methods. Our analyses associated unbound ATV disposition with multidrug resistance protein (MRP)4, RTV with P-glycoprotein (P-gp), and EFV with cytochrome P450 (CYP)2B6 and MRP4 genetic variants...
December 3, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/29205192/genetic-diversity-study-of-various-%C3%AE-lactamase-producing-multidrug-resistant-escherichia-coli-isolates-from-a-tertiary-care-hospital-using-eric-pcr
#12
Jayanti Jena, Nagen Kumar Debata, Rajesh Kumar Sahoo, Mahendra Gaur, Enketeswara Subudhi
BACKGROUND & OBJECTIVES: The prevalence of multidrug-resistant (MDR) Escherichia coli isolates producing β-lactamase enzyme is a growing problem across the globe. Strain typing is an epidemiologically important tool not only for detecting the cross transmission of nosocomial pathogens but also for determining the source of infection. The present study was conducted to understand the clonal relationship among various β-lactamase-producing MDR E. coli isolates using enterobacterial repetitive intergenic consensus (ERIC) polymerase chain reaction (PCR)...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29204285/molecular-characterization-of-acinetobacter-baumannii-isolated-from-iraqi-hospital-environment
#13
I M S Al-Kadmy, A N M Ali, I M A Salman, S S Khazaal
Healthcare-associated items are a common source of acquired infections, and hospital-acquired infections cause significant mortality and morbidity worldwide. Acinetobacter baumannii is the most prevalent infection-causing organism in the hospital environment. Hospital articles and objects are the main sources of infection with the ability to transmit some of the pathogenic microorganisms such as A. baumannii, which is considered a serious problem in therapeutic treatments. In the current study, we isolated A...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29203448/surface-disinfection-challenges-for-candida-auris-an-in-vitro-study
#14
Ryan Kean, Leighann Sherry, Eleanor Townsend, Emily McKloud, Bryn Short, Ayorinde Akinbobola, William G Mackay, Craig Williams, Brian L Jones, Gordon Ramage
The emerging pathogenic multidrug-resistant yeast Candida auris is an important source of healthcare-associated infections and of growing global clinical concern. The ability of this organism to survive on surfaces and withstand environmental stressors creates a challenge for eradicating it from hospitals. A panel of C. auris clinical isolates was evaluated on different surface environments against the standard disinfectant sodium hypochlorite and high level disinfectant peracetic acid. C. auris was shown to selectively tolerate clinically relevant concentrations of sodium hypochlorite and peracetic acid in a surface dependent manner, which may explain its ability to successfully persist within the hospital environment...
December 1, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29202138/effects-and-time-kill-assessment-of-amoxicillin-used-in-combination-with-chloramphenicol-against-bacteria-of-clinical-importance
#15
Olufunmiso O Olajuyigbe, Roger M Coopoosamy, Anthony J Afolayan
With the emergence of multidrug-resistant organisms in an era when drug development faces challenges causing pharmaceutical companies to curtail or abandon research on anti-infective agents, the use of combined existing antimicrobial agents may be an alternative. This study evaluated the effects of combining amoxicillin and chloramphenicol, to which many bacteria have become resistant, in vitro against Gram positive and Gram negative bacteria by agar diffusion, checkerboard and time-kill assays. The test isolates were susceptible to amoxicillin with minimum inhibitory concentrations (MICs) ranging between 0...
November 30, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29201657/tuberculosis-among-migrants-in-bishkek-the-capital-of-the-kyrgyz-republic
#16
O Goncharova, O Denisiuk, R Zachariah, K Davtyan, D Nabirova, C Acosta, A Kadyrov
Setting: Twenty-two first-line, two second-line and one tertiary health facility in Bishkek, the capital of Kyrgyzstan. Objectives: Among migrants, a marginalised population at risk for acquiring and transmitting tuberculosis (TB), we determined the proportion with TB among all registered TB cases. For those registered at primary-level facilities, we then reported on their demographic and clinical profiles and TB treatment outcomes. Design: This was a retrospective cohort analysis of 2012-2013 programme data...
September 21, 2017: Public Health Action
https://www.readbyqxmd.com/read/29197427/mycobacterium-tuberculosis-complex-drug-resistance-in-a-high-tuberculosis-incidence-area-from-the-who-eastern-mediterranean-region
#17
Noormohamad Mansoori, Masoumeh Douraghi, Ali Akbar Rajabloo, Masoomeh Taziki, Mehdi Yaseri, Farzam Vaziri
PURPOSE: The incidence of tuberculosis (TB) in Golestan province of Iran has been ranked 10th among countries of World Health Organization (WHO) Eastern Mediterranean Region. The province is residence of ethnically heterogeneous groups. However, there are limited data on Mycobacterium tuberculosis drug resistance in this province. The main aim of this study was to determine the resistance profile of M. tuberculosis complex (MTBC) isolates to first-line anti-TB drugs. METHODS: The clinical specimens were collected from 11807 cases diagnosed during this study...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29194526/bacterial-infections-after-burn-injuries-impact-of-multidrug-resistance
#18
Anne M Lachiewicz, Christopher G Hauck, David J Weber, Bruce A Cairns, David van Duin
Patients who are admitted to the hospital after sustaining a large burn injury are at high risk for developing hospital-associated infections. If patients survive the initial 72 hours after a burn injury, infections are the most common cause of death. Ventilator-associated pneumonia is the most important infection in this patient population. The risk of infections caused by multidrug-resistant bacterial pathogens increases with hospital length of stay in burn patients. In the first days of the postburn hospitalization, more susceptible, Gram-positive organisms predominate, whereas later more resistant Gram-negative organisms are found...
November 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29194365/the-role-of-resveratrol-in-cancer-therapy
#19
REVIEW
Jeong-Hyeon Ko, Gautam Sethi, Jae-Young Um, Muthu K Shanmugam, Frank Arfuso, Alan Prem Kumar, Anupam Bishayee, Kwang Seok Ahn
Abstract: Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, including cancer. A significant amount of research, including preclinical, clinical, and epidemiological studies, has indicated that dietary consumption of polyphenols, found at high levels in cereals, pulses, vegetables, and fruits, may prevent the evolution of an array of diseases, including cancer. Cancer development is a carefully orchestrated progression where normal cells acquires mutations in their genetic makeup, which cause the cells to continuously grow, colonize, and metastasize to other organs such as the liver, lungs, colon, and brain...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29191227/performance-of-mtbdrplus-assay-in-detecting-multidrug-resistant-tuberculosis-at-hospital-level
#20
Abebaw Kebede, Daniel Demisse, Meazashwork Assefa, Zerihun Getachew, Bazezew Yenew, Yared Tedla, Gobena Ameni
OBJECTIVE: Multidrug-resistant tuberculosis (MDR-TB) case finding progressively increased in Ethiopia mainly as a result of the utilization of World Health Organization (WHO)-endorsed rapid technologies including MTBDRplus assay. However, there is inadequate data on routine testing performance of the MTBDRplus assay. Consequently, the aim of the study was to assess the routine performance of the MTBDRplus assay in detecting MDR-TB at St. Peter's TB Specialized Hospital. RESULTS: The sensitivity and specificity of MTBDRplus in detecting isoniazid (INH) resistance were 96...
December 1, 2017: BMC Research Notes
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