keyword
MENU ▼
Read by QxMD icon Read
search

Multidrug resistant organism

keyword
https://www.readbyqxmd.com/read/28728967/impact-of-the-microbiota-on-bacterial-infections-during-cancer-treatment
#1
REVIEW
Jessica Galloway-Peña, Chelcy Brumlow, Samuel Shelburne
Patients being treated for cancer are at high risk for infectious complications, generally due to colonizing organisms that gain access to sterile sites via disrupted epithelial barriers. There is an emerging understanding that the ability of bacterial pathogens, including multidrug-resistant organisms, to colonize and subsequently infect humans is largely dependent on protective bacterial species present in the microbiome. Thus, herein we review recent studies demonstrating strong correlations between the microbiome of the oncology patient and infections occurring during chemotherapy...
July 17, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28723468/trends-in-antibiotic-resistance-in-urologic-practice
#2
REVIEW
Hala Kandil, Emma Cramp, Tejal Vaghela
CONTEXT: The significant global upsurge in antimicrobial resistance, particularly among Enterobacteriaceae, represents a serious threat to health care systems. The implications for urologic practice are of particular concern. OBJECTIVE: To review trends in antibiotic resistance in urologic practice. EVIDENCE ACQUISITION: We report current European trends of resistance in Gram-negative uropathogens. EVIDENCE SYNTHESIS: In addition to β-lactam resistance, Gram-negative pathogens are often resistant to multiple drug classes, including aminoglycosides, fluoroquinolones, and carbapenems, commonly used to treat urologic infections...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28722595/multidrug-resistant-microorganisms-colonizing-lower-extremity-wounds-in-patients-in-a-tertiary-care-hospital-lima-peru
#3
Rafael Mendo-Lopez, Luis Jasso, Ximena Guevara, Aurora Lizeth Astocondor, Saul Alejos, Ana C Bardossy, Tyler Prentiss, Marcus J Zervos, Jan Jacobs, Coralith García
Multidrug-resistant organism (MDRO) infections cause high morbidity and mortality, and high costs to patients and hospitals. The study aims were to determine the frequency of MDRO colonization and associated factors in patients with lower-extremity wounds with colonization. A cross-sectional study was designed during November 2015 to July 2016 in a tertiary care hospital in Lima, Peru. A wound swab was obtained for culture and susceptibility testing. MDRO colonization was defined if the culture grew with methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and/or extended spectrum beta-lactamase (ESBL) microorganisms...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718238/bacteriology-of-diabetic-foot-in-tertiary-care-hospital-frequency-antibiotic-susceptibility-and-risk-factors
#4
Syeda Sadia Amjad, Jamal Zafar, Nadia Shams
BACKGROUND: Diabetic foot being one of the frequent and disabling complications of diabetes. In view of widespread regional variation in causative organisms and antimicrobial susceptibility, the current study aimed to determine frequency of causative organisms, their antimicrobial susceptibility and associated risk factors. METHODS: This descriptive cross-sectional study was conducted in 6 months' duration at dept. of Medicine; PIMS Hospital Islamabad. Type 2 Diabetes mellitus patients with diabetic foot ulcer were enrolled after informed consent...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28714913/novel-fri1-like-viruses-infecting-acinetobacter-baumannii-vb_abap_as11-and-vb_abap_as12-characterization-comparative-genomic-analysis-and-host-recognition-strategy
#5
Anastasia V Popova, Daria G Lavysh, Evgeniy I Klimuk, Mikhail V Edelstein, Alexander G Bogun, Mikhail M Shneider, Artemiy E Goncharov, Sergey V Leonov, Konstantin V Severinov
Acinetobacter baumannii is a gram-negative, non-fermenting aerobic bacterium which is often associated with hospital-acquired infections and known for its ability to develop resistance to antibiotics, form biofilms, and survive for long periods in hospital environments. In this study, we present two novel viruses, vB_AbaP_AS11 and vB_AbaP_AS12, specifically infecting and lysing distinct multidrug-resistant clinical A. baumannii strains with K19 and K27 capsular polysaccharide structures, respectively. Both phages demonstrate rapid adsorption, short latent periods, and high burst sizes in one-step growth experiments...
July 17, 2017: Viruses
https://www.readbyqxmd.com/read/28714912/urinary-excretion-of-tetrodotoxin-modeled-in-a-porcine-renal-proximal-tubule-epithelial-cell-line-llc-pk%C3%A2
#6
Takuya Matsumoto, Yui Ishizaki, Keika Mochizuki, Mitsuru Aoyagi, Yoshiharu Mitoma, Shoichiro Ishizaki, Yuji Nagashima
This study examined the urinary excretion of tetrodotoxin (TTX) modeled in a porcine renal proximal tubule epithelial cell line, LLC-PK₁. Time course profiles of TTX excretion and reabsorption across the cell monolayers at 37 °C showed that the amount of TTX transported increased linearly for 60 min. However, at 4 °C, the amount of TTX transported was approximately 20% of the value at 37 °C. These results indicate that TTX transport is both a transcellular and carrier-mediated process. Using a transport inhibition assay in which cell monolayers were incubated with 50 µM TTX and 5 mM of a transport inhibitor at 37 °C for 30 min, urinary excretion was significantly reduced by probenecid, tetraethylammonium (TEA), l-carnitine, and cimetidine, slightly reduced by p-aminohippuric acid (PAH), and unaffected by 1-methyl-4-phenylpyridinium (MPP+), oxaliplatin, and cefalexin...
July 17, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28710611/bad-bacteria-in-acute-appendicitis-rare-but-relevant
#7
Alexander Reinisch, Patrizia Malkomes, Nils Habbe, Wolf Otto Bechstein, Juliane Liese
PURPOSE: Bacterial infections are a factor for morbidity in patients with acute appendicitis (AA). The spreading of multidrug-resistant (MDR) bacteria is a significant problem in surgery, and the most relevant MDR pathogens are summarized as Enterobacteriaceae, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterococci (ESKAPE) bacteria. Data regarding the species and distribution of bacteria in AA are available, but information about the resistances and their relevance is deficient...
July 15, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28708371/exploring-new-mechanisms-for-effective-antimicrobial-materials-electric-contact-killing-based-on-multiple-schottky-barriers
#8
Eva De Lucas-Gil, Julián Jiménez Reinosa, Kerstin Neuhaus, Liliana Vera, Marisol S Martin-Gonzalez, Jose F Fernandez, Fernando Rubio-Marcos
The increasing threat of multidrug-resistance organisms is a cause for worldwide concern. Progressively microorganisms become resistant to commonly used antibiotics, which are a healthcare challenge. Thus, the discovery of new antimicrobial agents or new mechanisms different from those used is necessary. Here, we report an effective and selective antimicrobial activity of microstructured ZnO (Ms-ZnO) agent through the design of a novel star-shaped morphology, resulting in modulation of surface charge orientation...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28706391/utility-of-a-novel-chromogenic-medium-as-a-screening-method-in-the-detection-of-carbapenemase-producing-enterobacteriaceae
#9
Anusha Chaturvedi, Gunjiganur Shankarappa Banashankari
INTRODUCTION: With the emergence of multidrug resistant Gram-negative bugs, there is an urgent need for rapid detection of these resistant organisms. AIM: This study was performed to assess the utility of a novel chromogenic medium in the detection of carbapenemase producing Enterobacteriaceae from various clinical specimens. MATERIALS AND METHODS: A total of 202 isolates of Enterobacteriaceae, which were resistant to meropenem (10 μg) disc by standard disc diffusion method, were analyzed over a period of 6 months...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28701170/antimicrobial-susceptibility-among-gram-positive-and-gram-negative-organisms-collected-from-the-latin-american-region-between-2004-and-2015-as-part-of-the-tigecycline-evaluation-and-surveillance-trial
#10
Silvio Vega, Michael J Dowzicky
BACKGROUND: The in vitro activity of tigecycline and comparator agents was evaluated against Gram-positive and Gram-negative isolates collected in Latin American centers between 2004 and 2015 as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) global surveillance study. METHODS: Minimum inhibitory concentrations (MICs) were determined using the broth microdilution methodology according to the Clinical and Laboratory Standards Institute (CLSI) guidelines...
July 12, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28700048/distribution-of-the-bla-oxa-bla-veb-1-and-bla-ges-1-genes-and-resistance-patterns-of-esbl-producing-pseudomonas-aeruginosa-isolated-from-hospitals-in-tehran-and-qazvin-iran
#11
Sahar Amirkamali, Taghi Naserpour-Farivar, Khadijeh Azarhoosh, Amir Peymani
INTRODUCTION: Pseudomonas aeruginosa is one of the most common nosocomial pathogens. The emergence of extended spectrum β-lactamases (ESBLs) has been increasingly reported as a major clinical concern worldwide. The main aim of the present study was to determine the distribution of bla OXA, bla PER-1, bla VEB-1, and bla GES-1 genes among ESBL-producing P. aeruginosa isolated from two distinct provinces in Iran. METHODS: In this study, a total of 75 (27.5%) ESBL-producing isolates were identified from 273 P...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28694232/reinforcement-of-an-antimicrobial-stewardship-task-force-aims-at-a-better-use-of-antibiotics-of-last-resort-the-colitifos-study
#12
Benjamin Davido, Frédérique Bouchand, Aurélien Dinh, Christian Perronne, Maryvonne Villart, Olivia Senard, Jérome Salomon
BACKGROUND: Physicians are facing a worldwide increase in multidrug-resistant (MDR) organisms. Eradication of such bacteria, including so called superbugs (XDR), may cause physicians to prescribe last-resort antibiotics. However, experience with these drugs is limited and few data are available. METHODS: A before and after retrospective study was conducted from January 2008 to June 2016. Prescriptions of parenteral antimicrobials considered as last-resort antibiotics (colistin, fosfomycin, tigecycline and temocillin) were reviewed by 4 infectious disease specialists (according to microbiology results, susceptibility testing, clinical situation and alternative agents), while doses were analyzed by a pharmacist...
July 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28693658/patient-hand-colonization-with-mdros-is-associated-with-environmental-contamination-in-post-acute-care
#13
Payal K Patel, Julia Mantey, Lona Mody
We assessed multidrug-resistant organism (MDRO) patient hand colonization in relation to the environment in post-acute care to determine risk factors for MDRO hand colonization. Patient hand colonization was significantly associated with environmental contamination. Risk factors for hand colonization included disability, urinary catheter, recent antibiotic use, and prolonged hospital stay. Infect Control Hosp Epidemiol 2017:1-4.
July 11, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28691772/successful-liver-transplantation-despite-donor-transmitted-esbl-producing-klebsiella-pneumoniae-infection-case-report-and-review-of-the-literature
#14
Laura Escolà-Vergé, Ibal Los-Arcos, Junajo González, Mayli Lung, Itxarone Bilbao, Mercè Farré, Teresa Pont, Alberto Sandiumenge, Joan Gavalda, Oscar Len
Donor-derived bacterial infection is a recognized complication of solid organ transplantation. Patients admitted to the intensive care unit are increasingly exposed to infection with multidrug-resistant microorganisms. However, no specific recommendations are available about their suitability as donors. We report a case of donor-transmitted extended-spectrum beta-lactamase-producing Klebsiella pneumoniae infection in a liver recipient, and review the related literature. This article is protected by copyright...
July 10, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28690026/antimicrobial-peptides-as-potential-anti-biofilm-agents-against-multidrug-resistant-bacteria
#15
REVIEW
Pooi Yin Chung, Ramona Khanum
Bacterial resistance to commonly used drugs has become a global health problem, causing increased infection cases and mortality rate. One of the main virulence determinants in many bacterial infections is biofilm formation, which significantly increases bacterial resistance to antibiotics and innate host defence. In the search to address the chronic infections caused by biofilms, antimicrobial peptides (AMP) have been considered as potential alternative agents to conventional antibiotics. Although AMPs are commonly considered as the primitive mechanism of immunity and has been extensively studied in insects and non-vertebrate organisms, there is now increasing evidence that AMPs also play a crucial role in human immunity...
June 26, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28688954/rifampicin-induced-injury-in-hepg2-cells-is-alleviated-by-tudca-via-increasing-bile-acid-transporters-expression-and-enhancing-the-nrf2-mediated-adaptive-response
#16
Weiping Zhang, Lihong Chen, Hui Feng, Wei Wang, Yi Cai, Fen Qi, Xiaofang Tao, Jun Liu, Yujun Shen, Xiaofei Ren, Xi Chen, Jianming Xu, Yuxian Shen
Bile acid transporters and the nuclear factor erythroid 2-related factor (Nrf-2)-mediated adaptive response play important roles in the development of drug-induced liver injury (DILI). However, little is known about the contribution of the adaptive response to rifampicin (RFP)-induced cell injury. In this study, we found RFP decreased the survival rate of HepG2 cells and increased the levels of lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP), γ-glutamyl-transferase (γ-GT), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), total bile acid (TBA) and adenosine triphosphate (ATP) in the cell culture supernatants in both a concentration- and a time-dependent manner...
July 6, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28687211/preventing-transmission-of-multidrug-resistant-pathogens-in-the-intensive-care-unit
#17
REVIEW
Jeffrey R Strich, Tara N Palmore
Infection control in the intensive care unit (ICU) has seen many advances, including rapid molecular screening tests for resistant organisms and chlorhexidine use in daily baths. Although these developments advance the cause of infection prevention, compliance with some of the basic measures remains elusive. Hand hygiene, antimicrobial stewardship, and reduction in device use remain the low-technology interventions that could have a major impact on nosocomial transmission of antimicrobial-resistant organisms...
July 5, 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28681083/a-novel-protocol-obviates-endoscope-sampling-for-carbapenem-resistant-enterobacteriaceae-experience-of-a-center-with-a-prior-outbreak
#18
Zachary L Smith, Arshish Dua, Kia Saeian, Nathan A Ledeboer, Mary Beth Graham, Murad Aburajab, Darren D Ballard, Abdul H Khan, Kulwinder S Dua
BACKGROUND: Numerous published outbreaks, including one from our institution, have described endoscope-associated transmission of multidrug-resistant organisms (MDROs). Individual centers have adopted their own protocols to address this issue, including endoscope culture and sequestration. Endoscope culturing has drawbacks and may allow residual bacteria, including MDROs, to go undetected after high-level disinfection. AIM: To report the outcome of our novel protocol, which does not utilize endoscope culturing, to address our outbreak...
July 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28676346/bloodstream-infections-caused-by-acinetobacter-species-with-reduced-susceptibility-to-tigecycline-clinical-features-and-risk-factors
#19
Ga Eun Park, Cheol-In Kang, Min Kyeong Cha, Sun Young Cho, Hyeri Seok, Ji Hye Lee, Ji Yeon Kim, Young Eun Ha, Doo Ryeon Chung, Kyong Ran Peck, Nam Yong Lee, Jae-Hoon Song
INTRODUCTION: During recent decades, the rates of multidrug resistance, including resistance to carbapenems, have increased dramatically among Acinetobacter species. Tigecycline has activity against multidrug-resistant Acinetobacter spp, including carbapenem-resistant isolates. However, reports of tigecycline-resistant Acinetobacter spp are emerging from different parts of the world. The purpose of this study was to evaluate potential risk factors associated with tigecycline non-susceptible Acinetobacter bacteremia...
July 1, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28673700/antimicrobial-resistance-and-the-current-refugee-crisis
#20
REVIEW
Helena C Maltezou, Maria Theodoridou, George L Daikos
In the past few years, Europe has experienced an enormous influx of refugees and migrants owing to the ongoing civil war in Syria as well as conflicts, violence and instability in other Asian and African countries. Available data suggest that refugees carry a significant burden of multidrug-resistant (MDR) organisms, which is attributed to the rising antimicrobial resistance (AMR) rates in their countries of origin, both in healthcare settings and in the community. Transmission of MDR pathogens among refugees is facilitated by the collapsed housing, hygiene and healthcare infrastructures in several communities as well as poor hygiene conditions during their trip to destination countries...
July 1, 2017: Journal of Global Antimicrobial Resistance
keyword
keyword
67508
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"