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Carbapenemase resistant enterobacteriacea

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https://www.readbyqxmd.com/read/28216021/prevalence-antibiotic-susceptibility-and-characterization-of-antibiotic-resistant-genes-among-carbapenem-resistant-gram-negative-bacilli-and-yeast-in-intestinal-flora-of-cancer-patients-in-north-lebanon
#1
Rima Christophy, Marwan Osman, Hassan Mallat, Marcel Achkar, Azzam Ziedeh, Walid Moukaddem, Fouad Dabboussi, Monzer Hamze
The emergence and spread of carbapenem-resistant bacteria are a significant clinical and public health concern. The aim of the study is to determine the prevalence of intestinal carriage of carbapenem-resistant bacteria and yeasts in cancer patients under chemotherapy. 41 stool samples collected from cancer patients in Nini hospital in Tripoli, North Lebanon have been analyzed. After isolating yeasts and carbapenem-resistant bacteria, a biochemical identification and antimicrobial susceptibility profile were determined...
February 15, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28215914/fecal-carriage-of-mdros-in-a-population-of-lebanese-elderly-dynamics-and-impact-on-bacterial-fitness
#2
Caren Challita, Elias Dahdouh, Michel Attieh, Iman Dandachi, Elio Ragheb, Roy Taoutel, Carl Tanba, Ziad Daoud
Muti-Drug Resistant Organisms (MDROs) are problematic all over the world, especially in Lebanon. High fecal carriage rates of MDR Enterobacteriaceae were reported from Lebanese nursing homes. Some studies show that MDROs have a fitness cost as compared to sensitive isolates. In this study, the competitive growth of MDR Escherichia coli obtained from fecal samples from elderly is assessed. Fecal swabs from ten elderly patients from a Lebanese nursing home were obtained between June and December, 2015. Isolates were identified by API 20E and antimicrobial susceptibilities were determined...
February 16, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28205502/trends-in-carbapenemase-producing-enterobacteriaceae-france-2012-to-2014
#3
Laurent Dortet, Gaëlle Cuzon, Valérie Ponties, Patrice Nordmann
In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance mechanism to carbapenems and compared with results obtained during 2012 and 2013.The overall number of enterobacterial isolates with decreased susceptibility to carbapenems received at the NRC rapidly increased (more than twofold in two years) with a growing proportion of carbapenemase producers (23...
February 9, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28196696/patients-hospitalized-abroad-as-importers-of-multiresistant-bacteria-a-cross-sectional-study
#4
Tamim Khawaja, Juha Kirveskari, Sara Johansson, Juuso Väisänen, Aurora Djupsjöbacka, Annika Nevalainen, Anu Kantele
OBJECTIVES: The pandemic spread of multidrug-resistant (MDR) bacteria poses a threat to healthcare worldwide, with highest prevalence in indigent regions of the (sub)tropics. As hospitalization constitutes a major risk factor for colonization, infection control management in low-prevalence countries urgently needs background data on patients hospitalized abroad. METHODS: We collected data on 1122 patients who, after hospitalization abroad, were treated at the Helsinki University Hospital between 2010 and 2013...
February 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28182124/extended-spectrum-beta-lactamase-and-carbapenemase-producing-enterobacteriaceae-among-ethiopian-children
#5
Melese Hailu Legese, Gebru Mulugeta Weldearegay, Daniel Asrat
BACKGROUND: Infections by extended-spectrum beta-lactamase- (ESBL) and carbapenem-resistant Enterobacteriaceae (CRE) are an emerging problem in children nowadays. Hence, the aim of this study was to determine the prevalence of ESBL- and carbapenemase-producing Enterobacteriaceae among children suspected of septicemia and urinary tract infections (UTIs). METHODS: A cross-sectional study was conducted from January to March 2014. A total of 322 study participants suspected of septicemia and UTIs were recruited...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28167547/bacteremia-due-to-carbapenem-resistant-enterobacteriaceae-cre-a-multicenter-clinical-and-molecular-epidemiologic-analysis-in-the-nation-s-epicenter-for-cre
#6
Michael J Satlin, Liang Chen, Gopi Patel, Angela Gomez-Simmonds, Gregory Weston, Angela C Kim, Susan K Seo, Marnie E Rosenthal, Steven J Sperber, Stephen G Jenkins, Camille L Hamula, Anne-Catrin Uhlemann, Michael H Levi, Bettina C Fries, Yi-Wei Tang, Stefan Juretschko, Albert D Rojtman, Tao Hong, Barun Mathema, Michael R Jacobs, Thomas J Walsh, Robert A Bonomo, Barry N Kreiswirth
Although the New York/New Jersey (NY/NJ) area is an epicenter for carbapenem-resistant Enterobacteriaceae (CRE), there are few multicenter studies of CRE from this region. We characterized patients with CRE bacteremia in 2013 at eight NY/NJ medical centers and determined the prevalence of carbapenem resistance among Enterobacteriaceae bloodstream isolates and CRE resistance mechanisms, genetic backgrounds, capsular types (cps), and antimicrobial susceptibilities. Of 121 patients with CRE bacteremia, 50% had cancer or transplantation...
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28165890/enterobacteriaceae-harboring-ampc-blacmy-and-esbl-blactx-m-in-migratory-and-nonmigratory-wild-songbird-populations-on-ohio-dairies
#7
Dimitria A Mathys, Blake A Mathys, Dixie F Mollenkopf, Joshua B Daniels, Thomas E Wittum
Extended-spectrum β-lactamases (ESBLs) confer bacterial resistance to critically important antimicrobials, including extended-spectrum cephalosporins (ESCs). Livestock are important reservoirs for the zoonotic food-borne transmission of ESC-resistant enteric bacteria. Our aim is to describe the potential role of migratory and resident wild birds in the epidemiology of ESBL-mediated bacterial resistance on dairy farms. Using mist nets, we sampled wild migratory and resident birds either immediately adjacent to or 600 ft away from free-stall barns on three Ohio dairy farms during the 2014 and 2015 spring migrations...
February 6, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28161293/molecular-epidemiology-of-carbapenemase-producing-enterobacteriaceae-in-a-primary-care-hospital-in-japan-2010-2013
#8
Yuki Ohno, Akihiro Nakamura, Eriko Hashimoto, Hiroko Matsutani, Noriyuki Abe, Saori Fukuda, Kohno Hisashi, Masaru Komatsu, Fumihiko Nakamura
Recently, carbapenemase-producing Enterobacteriaceae (CPE) have been spreading worldwide and have become a threat in healthcare systems. We investigated the isolation frequency and molecular epidemiological characteristics of CPE isolated from clinical samples collected at a primary care hospital over the four years of 2010-2013 in Japan. CPE were detected in 17 (0.34%) of 4875 isolates by the broth microdilution method, sodium mercaptoacetate inhibition test, and modified Hodge test using meropenem disks. The frequency of CPE isolates was 0...
February 1, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28158310/retrospective-and-prospective-evaluation-of-the-carbapenem-inactivation-method-for-the-detection-of-carbapenemase-producing-enterobacteriaceae
#9
Lauraine Gauthier, Remy A Bonnin, Laurent Dortet, Thierry Naas
BACKGROUND: There is an urgent need for accurate and rapid diagnostic tests to identify carbapenemase producing enterobacteria (CPE). Here, we have evaluated the Carbapenem Inactivation Method (CIM) test to detect CPEs from cultured colonies. METHODS: A total of 256 enterobacterial isolates were used to evaluate the performance of the CIM in comparison to Carba NP test and molecular detection used a reference method. Ninety three well-characterized isolates (including 29 non-CPE and 63 CPEs of worldwide origin) with decreased susceptibility to at least one carbapenem were used to (i) evaluate the efficacy of CIM test and (ii) to compare it to the Carba NP test...
2017: PloS One
https://www.readbyqxmd.com/read/28156193/characterization-of-ndm-7-carbapenemase-producing-escherichia-coli-isolates-in-the-arabian-peninsula
#10
Tibor Pál, Akela Ghazawi, Dania Darwish, Laura Villa, Alessandra Carattoli, Rayhan Hashmey, Zulfa Aldeesi, Wafaa Jamal, Vincent Rotimi, Amina Al-Jardani, Seif S Al-Abri, Ágnes Sonnevend
AIM: The purpose of this study was to characterize the New Delhi metallo-beta lactamase (NDM)-7-producing Enterobacteriaceae isolated in the Arabian Peninsula. METHODS: Enterobacteriaceae identified to carry blaNDM-7 in a collection of 157 NDM-producing isolates from Kuwait, Oman, Saudi Arabia, and the United Arab Emirates (UAE) were investigated for their antibiotic and disinfectant susceptibility, and resistance gene content. The virulence profile, phylogenetic and sequence types of the isolates were also determined...
February 3, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28151407/rapid-detection-of-carbapenemases-in-enterobacteriaceae-evaluation-of-the-resist-3-o-k-n-oxa-48-kpc-ndm-multiplexed-lateral-flow-assay
#11
David W Wareham, Muhd Haziq F Abdul Momin
The identification, treatment and control of carbapenem resistant Enterobacteriaceae (CRE) infections are a major challenge for healthcare institutions and diagnostic laboratories worldwide.….
February 1, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28122803/a-decade-of-development-of-chromogenic-culture-media-for-clinical-microbiology-in-an-era-of-molecular-diagnostics
#12
REVIEW
John D Perry
In the last 25 years, chromogenic culture media have found widespread application in diagnostic clinical microbiology. In the last decade, the range of media available to clinical laboratories has expanded greatly, allowing specific detection of additional pathogens, including Pseudomonas aeruginosa, group B streptococci, Clostridium difficile, Campylobacter spp., and Yersinia enterocolitica. New media have also been developed to screen for pathogens with acquired antimicrobial resistance, including vancomycin-resistant enterococci, carbapenem-resistant Acinetobacter spp...
April 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28119479/diversity-and-functionality-of-plasmid-borne-vagcd-toxin-antitoxin-systems-of-klebsiella-pneumoniae
#13
Marion Duprilot, Dominique Decre, Nathalie Genel, Laurence Drieux, Wladimir Sougakoff, Guillaume Arlet
OBJECTIVES: To explore the VagCD toxin-antitoxin (TA) systems encoded on plasmids in multiresistant Klebsiella pneumoniae strains. METHODS: Previously sequenced K. pneumoniae plasmids were used for in silico analysis and a collection of 63 resistant K. pneumoniae strains was used for epidemiological study. Functional analysis was done after separate cloning of the toxin gene under the control of the arabinose-inducible promoter of pBAD43 and of the antitoxin gene under the control of the constitutive promoter of pUC19...
January 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28119478/rapid-direct-detection-of-carbapenemase-producing-enterobacteriaceae-in-clinical-urine-samples-by-maldi-tof-ms-analysis
#14
Marina Oviaño, Cecilia de la Luna Ramírez, Luis Pedro Barbeyto, Germán Bou
OBJECTIVES: Development of an automated MALDI-TOF MS-based method for the rapid, direct detection of carbapenemase-producing Enterobacteriaceae in clinical urine samples within 90 min of sample reception. METHODS: A total of 3041 urine samples were processed by flow cytometry, and a cut-off value of ≥1.5 × 10(5) bacteria/mL was used to select samples for the study. Following these criteria, 608 samples were selected for direct bacterial identification...
January 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28098536/emergence-of-blandm-7-producing-enterobacteriaceae-in-gabon-2016
#15
Mesmin Moussounda, Seydina M Diene, Sandra Dos Santos, Alain Goudeau, Patrice François, Nathalie van der Mee-Marquet
Reports of carbapenemase-producing Enterobacteriaceae in Africa remain rare and assess mostly blaOXA-48-producing isolates from Mediterranean countries and South Africa. We identified blaNDM-7-producing Enterobacteriaceae in Gabon in 2016. The isolates contained blaNDM-7 IncX3 plasmids that were unusual and similar to the one described in a colistin-resistant Klebsiella pneumoniae SZ04 isolate from China.
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28096418/multi-institute-analysis-of-carbapenem-resistance-reveals-remarkable-diversity-unexplained-mechanisms-and-limited-clonal-outbreaks
#16
Gustavo C Cerqueira, Ashlee M Earl, Christoph M Ernst, Yonatan H Grad, John P Dekker, Michael Feldgarden, Sinéad B Chapman, João L Reis-Cunha, Terrance P Shea, Sarah Young, Qiandong Zeng, Mary L Delaney, Diane Kim, Ellena M Peterson, Thomas F O'Brien, Mary Jane Ferraro, David C Hooper, Susan S Huang, James E Kirby, Andrew B Onderdonk, Bruce W Birren, Deborah T Hung, Lisa A Cosimi, Jennifer R Wortman, Cheryl I Murphy, William P Hanage
Carbapenem-resistant Enterobacteriaceae (CRE) are among the most severe threats to the antibiotic era. Multiple different species can exhibit resistance due to many different mechanisms, and many different mobile elements are capable of transferring resistance between lineages. We prospectively sampled CRE from hospitalized patients from three Boston-area hospitals, together with a collection of CRE from a single California hospital, to define the frequency and characteristics of outbreaks and determine whether there is evidence for transfer of strains within and between hospitals and the frequency with which resistance is transferred between lineages or species...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095794/development-of-an-algorithm-for-phenotypic-screening-of-carbapenemase-producing-enterobacteriaceae-in-the-routine-laboratory
#17
Jérôme Robert, Alix Pantel, Audrey Merens, Elodie Meiller, Jean-Philippe Lavigne, Marie-Hélène Nicolas-Chanoine
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) are difficult to identify among carbapenem non-susceptible Enterobacteriaceae (NSE). We designed phenotypic strategies giving priority to high sensitivity for screening putative CPE before further testing. METHODS: Presence of carbapenemase-encoding genes in ertapenem NSE (MIC > 0.5 mg/l) consecutively isolated in 80 French laboratories between November 2011 and April 2012 was determined by the Check-MDR-CT103 array method...
January 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28080212/heterogeneity-of-carbapenem-resistance-mechanisms-among-gram-negative-pathogens-in-lebanon-results-of-the-first-cross-sectional-countrywide-study
#18
Dalal Hammoudi Halat, Carole Ayoub Moubareck, Dolla Karam Sarkis
Carbapenem-resistant Gram-negative pathogens have progressively disseminated to different countries worldwide, presenting a serious public health concern. The aims of this study were to determine the prevalence of carbapenem resistance in Gram-negative bacteria in Lebanon, to elucidate molecular mechanisms, and to identify genetic relatedness of incriminated strains. Carbapenem nonsusceptible Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas were collected from 11 Lebanese hospitals in 2012. Antimicrobial susceptibility was assessed with phenotypic tests, genes encoding carbapenemases were screened via PCR-sequencing, and genetic relatedness was examined by PGFE and ERIC-PCR...
January 12, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28077701/a-comparison-of-eleven-phenotypic-assays-for-the-accurate-detection-of-carbapenemase-producing-enterobacteriaceae
#19
Pranita D Tamma, Belita N A Opene, Andrew Gluck, Krizia K Chambers, Karen C Carroll, Patricia J Simner
BACKGROUND: Early identification of carbapenemase-producing Enterobacteriaceae (CPE) is essential to prevent their dissemination within healthcare settings. Our objective was to evaluate the accuracy of 11 phenotypic assays for the detection of CPE. METHODS: Two collections of carbapenem-resistant Enterobacteriaceae (CRE) isolates were evaluated including 191 retrospective isolates (122 CP-CRE and 69 non-CP isolates) as well as 45 prospective clinical isolates (15 CP-CRE and 30 non-CP-CRE) obtained over a 3-month period...
January 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28074126/the-emergence-of-carbapenem-resistant-klebsiella-pneumoniae-in-malaysia-correlation-between-microbiological-trends-with-host-characteristics-and-clinical-factors
#20
Ye-Mun Low, Polly Soo-Xi Yap, Kartini Abdul Jabar, Sasheela Ponnampalavanar, Rina Karunakaran, Rukumani Velayuthan, Chun-Wie Chong, Sazaly Abu Bakar, Mohd Yasim Md Yusof, Cindy Shuan-Ju Teh
BACKGROUND: Carbapenem resistant Enterobacteriaceae is a growing concern worldwide including Malaysia. The emergence of this pathogen is worrying because carbapenem is one of the 'last-line' antibiotics. The main objective of this study was to determine the prevalence of genetic mechanisms and clinical risk factors of carbapenem resistant Klebsiella pneumoniae (K. pneumoniae) in Malaysia. METHODS: In this study, seventeen carbapenem resistant K. pneumoniae strains isolated from a tertiary teaching hospital in 2013 were studied...
2017: Antimicrobial Resistance and Infection Control
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