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Carbapenemase resistant enterobacteriacea

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https://www.readbyqxmd.com/read/29783023/extended-spectrum-beta-lactamase-producing-enterobacteriaceae-infections-in-haematopoietic-stem-cell-transplant-recipients-epidemiology-and-molecular-characterization
#1
Molka Kharrat, Yosra Chebbi, Farah Ben Tanfous, Amel Lakhal, Saloua Ladeb, Tarek Ben Othmen, Wafa Achour
BACKGROUND: Extended spectrum β-lactamase producing Enterobacteriaceae (ESBL-E) are feared because they generate therapeutic difficulties and have high potential for dissemination. The purpose of our study was to investigate the epidemiology of these infections in hematopoietic stem cell transplant (HSCT) recipients and to determine the genes encoding ESBL. MATERIAL/METHODS: Our retrospective study concerned adult patients hospitalized at the National Bone Marrow Transplant Center and infected with ESBL-E post HSCT between january 2006 and december 2016...
May 18, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29782539/comparison-of-two-commercial-carbapenemase-gene-confirmatory-assays-in-multiresistant-enterobacteriaceae-and-acinetobacter-baumannii-complex
#2
Stephan Rösner, Kevin Gehlweiler, Uta Küsters, Mathias Kolbert, Kirsten Hübner, Niels Pfennigwerth, Dietrich Mack
Multidrug-resistant Gram-negative bacilli (MDR-GNB) producing carbapenemases are increasing at an alarming speed. Rapid confirmation of carbapenemase type will be an important diagnostic step in clinical microbiology laboratories not only to reduce the risk of transmissions but also for optimising antibiotic therapy in the future. We compared diagnostic reliability of two commercially available molecular assays (Check-Direct CPE vs. AID line probe assay) for detection and typing of carbapenemase genes in 80 well-characterized isolates of MDR-GNB...
2018: PloS One
https://www.readbyqxmd.com/read/29782216/carbapenemase-producing-carbapenem-resistant-enterobacteriaceae-from-bangkok-thailand-and-their-detection-by-the-carba-np-and-modified-carbapenem-inactivation-method-tests
#3
Warawut Laolerd, Yukihiro Akeda, Likit Preeyanon, Panan Ratthawongjirakul, Pitak Santanirand
AIM: The purpose of the study was to determine the epidemiology of carbapenemase genes among carbapenem-resistant Enterobacteriaceae and evaluate the Carba NP and modified carbapenem inactivation method (mCIM) tests in their detection. MATERIALS AND METHODS: A total of 287 nonduplicated Enterobacteriaceae isolates, which were at least resistant to one of the carbapenems, were identified and detected for carbapenemase genes by multiplex PCR covering blaKPC , blaNDM , blaVIM , blaIMP , and blaOXA-48-like ...
May 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29776363/rapid-detection-of-carbapenemase-activity-of-enterobacteriaceae-isolated-from-positive-blood-cultures-by-maldi-tof-ms
#4
Jiajia Yu, Jingxian Liu, Yuanrui Li, Jing Yu, Weinan Zhu, Ying Liu, Lisong Shen
BACKGROUND: Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been proved to be a useful tool for identification of pathogens directly isolated from blood cultures in clinical microbiology laboratories. β-Lactam antibiotics are commonly used for treatment of bloodstream infections caused by Enterobacteriaceae strains, and carbapenem is the superlative class of β-lactam antibiotics. Since the carbapenem resistance rate of Enterobacteriaceae strains raised year by year, efficient detection of carbapenemase activity and timely delivery of carbapenem susceptibility reports of Enterobacteriaceae strains isolated from blood cultures is important for clinicians...
May 18, 2018: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29769274/a-comparative-evaluation-of-four-phenotypic-methods-for-detection-of-class-a-and-b-carbapenemase-producing-enterobacteriaceae-in-china
#5
Menglan Zhou, Danchen Wang, Timothy Kudinha, Qiwen Yang, Shuying Yu, Ying-Chun Xu
Objectives: To evaluate the performance of four phenotypic methods in the detection of carbapenemase-producing Enterobacteriaceae (CPE) in China. Methods: We evaluated the performance of four carbapenemase detection methods, the modified Hodge test (MHT), Carba NP test, meropenem hydrolysis assay (MHA) with 1 and 2-hour incubation, and modified carbapenem inactivation method (mCIM) with meropenem, imipenem, and ertapenem, on 342 carbapenem-resistant Enterobacteriaceae (CRE) in China. Polymerase chain reaction was used as the gold standard...
May 16, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29760135/-in-vitro-activity-of-imipenem-relebactam-against-clinical-isolates-of-gram-negative-bacilli-isolated-in-hospital-laboratories-in-the-united-states-smart-2016
#6
James A Karlowsky, Sibylle H Lob, Krystyna M Kazmierczak, Katherine Young, Mary R Motyl, Daniel F Sahm
Relebactam is a non-β-lactam, bicyclic diazabicyclooctane β-lactamase inhibitor of class A and class C β-lactamases, including Klebsiella pneumoniae carbapenemases (KPCs). It is in phase 3 clinical development in combination with imipenem/cilastatin. The in vitro activities of imipenem-relebactam, imipenem, and comparators were determined using the Clinical and Laboratory Standards Institute (CLSI) reference broth microdilution method for isolates of Enterobacteriaceae ( n =3,419) and Pseudomonas aeruginosa ( n =896) collected in 2016 by 21 U...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29760124/-in-vitro-activity-of-ceftazidime-avibactam-against-clinical-isolates-of-enterobacteriaceae-and-pseudomonas-aeruginosa-collected-in-asia-pacific-countries-results-from-the-inform-global-surveillance-program-2012-2015
#7
James A Karlowsky, Krystyna M Kazmierczak, Samuel K Bouchillon, Boudewijn L M de Jonge, Gregory G Stone, Daniel F Sahm
The in vitro activities of ceftazidime-avibactam and comparators were determined for 9,149 isolates of Enterobacteriaceae and 2,038 isolates of Pseudomonas aeruginosa collected by 42 medical centers in nine countries in the Asia-Pacific region from 2012 to 2015 as part of the International Network For Optimal Resistance Monitoring (INFORM) global surveillance program. Antimicrobial susceptibility testing was conducted by CLSI broth microdilution and isolate subset analysis performed based on resistant phenotypes and β-lactamase content...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29730830/the-epidemiology-evolution-and-treatment-of-kpc-producing-organisms
#8
REVIEW
Ann Marie Porreca, Kaede V Sullivan, Jason C Gallagher
PURPOSE OF REVIEW: The purpose of this review is to investigate the evolution and epidemiology of Klebsiella pneumoniae carbapenemase (KPC)-producing organisms and the current and future treatment options for infections caused by KPC-producing isolates. RECENT FINDINGS: The emergence of resistance in Enterobacteriaceae producing carbapenemases globally has increased the challenges in treating infections caused by these organisms. One of the prominent mechanisms of resistance is the production of KPC enzymes...
May 5, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29728111/emergence-of-multidrug-resistant-providencia-rettgeri-isolates-co-producing-ndm-1-carbapenemase-and-per-1-extended-spectrum-%C3%AE-lactamase-causing-a-first-outbreak-in-korea
#9
Saeam Shin, Seok Hoon Jeong, Hyukmin Lee, Jun Sung Hong, Min-Jeong Park, Wonkeun Song
BACKGROUND: Nosocomial outbreak due to carbapenem-resistant Enterobacteriaceae has become serious challenge to patient treatment and infection control. We describe an outbreak due to a multidrug-resistant Providencia rettgeri from January 2016 to January 2017 at a University Hospital in Seoul, Korea. METHODS: A total of eight non-duplicate P. rettgeri isolates were discovered from urine samples from eight patients having a urinary catheter and admitted in a surgical intensive care unit...
May 5, 2018: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29727717/coexistence-of-ndm-1-producing-escherichia-coli-and-citrobacter-freundii-in-the-same-patient
#10
Bo Zhu, Chaoqun Ying, Hao Xu, Jingjing Ying
OBJECTIVES: Although blaNDM-1 has now been widely detected in various Enterobacteriaceae clinical isolates, multiple blaNDM-1 colonizations within the same patient remain rare. The aim of the study was to describe a patient with respiratory tract colonization of NDM-1-producing Escherichia coli and Citrobacter freundii during a hospitalization in China. METHODS: Two carbapenem-resistant isolates were analysed. Susceptibility testing, metallo-β-lactamase production, conjugation, plasmid analysis, and molecular typing were performed...
May 1, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29713466/dissemination-of-bla-ndm-5-gene-via-an-incx3-type-plasmid-among-non-clonal-escherichia-coli-in-china
#11
Xi Li, Ying Fu, Mengyuan Shen, Danyan Huang, Xiaoxing Du, Qingfeng Hu, Yonglie Zhou, Dairong Wang, Yunsong Yu
Background: The emergence and spread of New Delhi metallo-β-lactamase-producing Enterobacteriaceae has been a serious challenge to manage in the clinic due to its rapid dissemination of multi-drug resistance worldwide. As one main type of carbapenemases, New Delhi metallo-β-lactamase (NDM)is able to confer resistance to almost all β-lactams, including carbapenems, in Enterobacteriaceae . Recently, New Delhi metallo-β-lactamase-5 attracted extensive attention because of increased resistance to carbapenems and widespread dissemination...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29709404/microbiology-of-french-military-casualties-repatriated-from-overseas-for-an-open-traumatic-injury
#12
S Larréché, A Bousquet, C Soler, C Mac Nab, D de Briel, D Delaune, C Bigaillon, P Pasquier, C Dubost, T Demoures, B Malgras, S Ausset, S de Rudnicki, T Leclerc, B de Loynes, S Bonnet, N Mocellin, C Ficko, R Haus, O Hersan, S Rigal, A Mérens
BACKGROUND: This study aimed to describe the microbiological epidemiology of repatriated French soldiers with an open traumatic injury, and to measure the proportion of multidrug-resistant bacteria (MDRB). METHODS: Retrospective study including all French soldiers repatriated in 2011 and 2012 in Parisian military hospitals for open traumatic injury. Results of clinical samples and MDRB screening were collected. The antibiotic susceptibility was assessed using the agar disk diffusion method...
April 27, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29698126/whole-genome-sequencing-of-ndm-1-producing-st11-klebsiella-pneumoniae-isolated-in-a-private-laboratory-in-greece
#13
Georgios Meletis, Fani Chatzopoulou, Dimitrios Chatzidimitriou, Fani Tsingerlioti, Christina Botziori, Georgios Tzimagiorgis, Lemonia Skoura
The emergence and spread of NDM-1-encoding Klebsiella pneumoniae is causing worldwide concern, whereas a second epicenter of their dissemination after the Indian subcontinent is thought to be located in the Balkans. In this study, the complete genome sequencing of an NDM-1-producing ST11 K. pneumoniae isolated in a private laboratory in Greece is presented. The genome sequencing was performed on Illumina MiniSeq. Multilocus Sequence Typing was determined using a BLAST-based approach whereas antimicrobial resistance genes and plasmid replicons were identified by ResFinder and PlasmidFinder respectively...
April 26, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29692574/phenotypic-and-genotypic-characterization-of-carbapenem-resistance-mechanisms-in-klebsiella-pneumoniae-from-blood-culture-specimens-a-study-from-north-india
#14
Varsha Gupta, Ritu Garg, Karthikeyan Kumaraswamy, Priya Datta, Gursimran Kaur Mohi, Jagdish Chander
BACKGROUND: Emergence of carbapenem resistance among Enterobacteriaceae in different geographical regions is of great concern as these bacteria are easily transmissible among patients. Carbapenem-resistance in Enterobacteriaceae is due to production of carbapenemases of various classes and hyper production of the ESBLs (Extended spectrum beta lactamases) and Amp C beta lactamases with reduced cell wall permeability mechanisms. Phenotypic detection and differentiation is important for proper infection control and appropriate patient management...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29692474/molecular-detection-of-bla-ndm-1-new-delhi-metallobetalactamase-1-in-nosocomial-enterobacteriaceae-isolates-by-nested-multiplex-polymerase-chain-reaction
#15
Parnika Chandola, R M Gupta, Mahima Lall, Sourav Sen, S P S Shergill, Vibha Dutta
Background: Carbapenems are considered "drugs of last resort" in many life-threatening infections. Advent of carbapenemases like KPC, OXA-48, VIM, IMP, and NDM have greatly affected the efficacy of these drugs, posing serious threat to global health and infection control. NDM bears special significance to the India subcontinent, labeled as place of origin and reservoir. NDM tends to escape detection by routine phenotypic methods, requiring molecular confirmation. This study utilizes nested, multiplex polymerase chain reaction (PCR) for reliable detection of bla NDM-1 in nosocomial Enterobacteriaceae isolates...
April 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29692218/meropenem-vaborbactam-a-new-weapon-in-the-war-against-infections-due-to-resistant-gram-negative-bacteria
#16
Twisha S Patel, Jason M Pogue, John P Mills, Keith S Kaye
Meropenem-vaborbactam is a fixed-dose combination product of a carbapenem and a cyclic boronic acid β-lactamase inhibitor with potent in vitro activity against Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CRE). The efficacy of meropenem-vaborbactam for the treatment of complicated urinary tract infections and acute pyelonephritis was demonstrated in a Phase III trial (TANGO I). Preliminary data from TANGO II, a separate Phase III study, support the efficacy of meropenem-vaborbactam for the treatment of infections caused by CRE...
April 25, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29688801/genomic-characterization-of-nonclonal-mcr-1-positive-multidrug-resistant-klebsiella-pneumoniae-from-clinical-samples-in-thailand
#17
Apichai Srijan, Katie R Margulieux, Sirigade Ruekit, Erik Snesrud, Rosslyn Maybank, Oralak Serichantalergs, Rosarin Kormanee, Prawet Sukhchat, Jossin Sriyabhaya, Mary Hinkle, John M Crawford, Patrick McGann, Brett E Swierczewski
Multidrug-resistant Klebsiella pneumoniae strains are one of the most prevalent causes of nosocomial infections and pose an increasingly dangerous public health threat. The lack of remaining treatment options has resulted in the utilization of older drug classes, including colistin. As a drug of last resort, the discovery of plasmid-mediated colistin resistance by mcr-1 denotes the potential development of pandrug-resistant bacterial pathogens. To address the emergence of the mcr-1 gene, 118 gram-negative Enterobacteriaceae isolated from clinical samples collected at Queen Sirikit Naval Hospital in Chonburi, Thailand were screened for colistin resistance using automated antimicrobial susceptibility testing and conventional PCR screening...
April 24, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29674034/a-voltammetric-test-for-the-rapid-discrimination-of-%C3%AE-lactamase-producing-enterobacteriaceae-in-blood-cultures
#18
Laetitia Betelli, Catherine Neuwirth, Sébastien Solanas, Benoît Chantemesse, Fabienne Vienney, Alain Hartmann, Murielle Rochelet
The accurate identification of β-lactamases produced by Enterobacteriaceae is a major challenge in clinical laboratories in order to optimize antimicrobial treatment and patient care. We describe here a rapid voltammetric-based method to detect and to discriminate β-lactamase activity in Enterobacteriaceae i.e., penicillinase, cephalosporinase (inducible or overproduced), extended-spectrum beta-lactamase and carbapenemase producers. After a 2-h growth step of the sample under three separate conditions: 1) LB (Luria-Bertani) medium, 2) LB supplemented with 4 μg/mL cefotaxime and 3) LB supplemented with 4 μg/mL cefotaxime and 100 μg/mL potassium clavulanate, the β-lactamase activity was measured by incubating a 0...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29671219/ceftazidime-avibactam-a-review-in-the-treatment-of-serious-gram-negative-bacterial-infections
#19
Matt Shirley
Ceftazidime-avibactam (Zavicefta® ) is an intravenously administered combination of the third-generation cephalosporin ceftazidime and the novel, non-β-lactam β-lactamase inhibitor avibactam. In the EU, ceftazidime-avibactam is approved for the treatment of adults with complicated urinary tract infections (cUTIs) [including pyelonephritis], complicated intra-abdominal infections (cIAIs), hospital-acquired pneumonia (HAP) [including ventilator-associated pneumonia (VAP)], and other infections caused by aerobic Gram-negative organisms in patients with limited treatment options...
April 18, 2018: Drugs
https://www.readbyqxmd.com/read/29670607/carbapenem-resistant-e-cloacae-in-southwest-china-molecular-analysis-of-resistance-and-risk-factors-for-infections-caused-by-ndm-1-producers
#20
Xiaojiong Jia, Wei Dai, Weijia Ma, Jinrong Yan, Jianchun He, Shuang Li, Congya Li, Shuangshuang Yang, Xiuyu Xu, Shan Sun, Jing Shi, Liping Zhang
Carbapenem-resistant Enterobacteriaceae (CRE) has been considered a serious global threat, but carbapenem resistance remains relatively uncommon in E. cloacae , especially in China. The aim of this study was to characterize carbapenem-resistant E. cloacae (CR-ECL) isolates from 2012 to 2016 in Southwest China. Our study revealed that 20 (15.2%) of the 132 CR-ECL isolates obtained from patients were identified as NDM-1, with most isolates carrying the IncFIIA plasmids. Notably, we initially observed that the E...
2018: Frontiers in Microbiology
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