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Chronic lymphedema

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https://www.readbyqxmd.com/read/28194353/labia-majora-share
#1
Hanjing Lee, Yan Lin Yap, Jeffrey Jen Hui Low, Jane Lim
Defects involving specialised areas with characteristic anatomical features, such as the nipple, upper eyelid, and lip, benefit greatly from the use of sharing procedures. The vulva, a complex 3-dimensional structure, can also be reconstructed through a sharing procedure drawing upon the contralateral vulva. In this report, we present the interesting case of a patient with chronic, massive, localised lymphedema of her left labia majora that was resected in 2011. Five years later, she presented with squamous cell carcinoma over the left vulva region, which is rarely associated with chronic lymphedema...
January 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28186091/topical-tacrolimus-for-the-treatment-of-secondary-lymphedema
#2
Jason C Gardenier, Raghu P Kataru, Geoffrey E Hespe, Ira L Savetsky, Jeremy S Torrisi, Gabriela D García Nores, Dawit K Jowhar, Matthew D Nitti, Ryan C Schofield, Dean C Carlow, Babak J Mehrara
Secondary lymphedema, a life-long complication of cancer treatment, currently has no cure. Lymphedema patients have decreased quality of life and recurrent infections with treatments limited to palliative measures. Accumulating evidence indicates that T cells play a key role in the pathology of lymphedema by promoting tissue fibrosis and inhibiting lymphangiogenesis. Here using mouse models, we show that topical therapy with tacrolimus, an anti-T-cell immunosuppressive drug, is highly effective in preventing lymphedema development and treating established lymphedema...
February 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28149940/wart-on-fire-a-rare-entity-of-verruciform-xanthoma-arising-on-a-lower-leg-in-a-setting-of-chronic-lymphedema
#3
Simon F Roy, Robert Prokopetz, Yasmine Ayroud, Laura Pickett, Ivan V Litvinov
No abstract text is available yet for this article.
January 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28135124/comparisons-between-cancer-related-and-noncancer-related-lymphedema-an-overview-of-new-patients-referred-to-a-specialized-hospital-based-center-in-canada
#4
Shirin M Shallwani, Pamela Hodgson, Anna Towers
BACKGROUND: Lymphedema is an irreversible inflammatory condition caused by accumulated lymph fluid and is associated with chronic swelling and increased risk of cellulitis. Our objectives were to: (1) describe the patient population referred to a Canadian lymphedema center and (2) compare lymphedema characteristics between patients with cancer and patients with noncancer diagnoses. METHODS AND RESULTS: A retrospective cohort study was conducted of new patients referred for suspected lymphedema to a hospital-based center over a 2-year period...
January 30, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28129845/the-lymphatic-vasculature-revisited-new-developments-in-the-zebrafish
#5
Y Padberg, S Schulte-Merker, A van Impel
The lymphatic system is lined by endothelial cells and part of the vasculature. It is essential for tissue fluid homeostasis, absorption of dietary fats, and immune surveillance in vertebrates. Misregulation of lymphatic vessel formation and dysfunction of the lymphatic system have been indicated in a number of pathological conditions including lymphedema formation, obesity or chronic inflammatory diseases such as rheumatoid arthritis. In zebrafish, lymphatics were discovered about 10years ago, and the underlying molecular pathways involved in its development have since been studied in detail...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28125537/the-lymphatic-response-to-injury-with-soft-tissue-reconstruction-in-high-energy-open-tibial-fractures-of-the-lower-extremity
#6
Malou C van Zanten, Raakhi M Mistry, Hiroo Suami, Andrew Campbell-Lloyd, James P Finkemeyer, Neil B Piller, Yugesh Caplash
BACKGROUND: Severe compound tibial fractures are associated with extensive soft-tissue damage, resulting in disruption of lymphatic pathways that leave the patient at risk of developing chronic lymphedema. There are limited data on lymphatic response following lower limb trauma. Indocyanine green fluorescence lymphography is a novel, real-time imaging technique for superficial lymphatic mapping. The authors used this technique to image the superficial lymphatic vessels of the lower limbs in patients with severe compound tibial fracture...
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28097676/morbihan-disease-complicated-by-dermatosis-neglecta-a-unique-presentation
#7
Ariel E Eber, Stephanie Mlacker, Sebastian Verne, Robert Griffith, Jennifer Ledon, Marina Perper, Keyvan Nouri, Jeong Hee Cho-Vega
Morbihan disease (MD), also referred to as solid facial edema, or rosacea lymphedema, is a rare disorder that involves chronic erythema and solid edema of the cheeks, eyelids, forehead and glabella and may arise as a complication of acne vulgaris or rosacea. Of note, it may be the only initial presenting symptom of these associated diseases.1,2 Few cases have been described in the literature, since its first description by Robert Degos in 1957. The condition is characterized by its chronicity, a typical clinical appearance, and the lack of specific histopathologic or laboratory findings...
January 18, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28054496/tailoring-exercise-interventions-to-comorbidities-and-treatment-induced-adverse-effects-in-patients-with-early-stage-breast-cancer-undergoing-chemotherapy-a-framework-to-support-clinical-decisions
#8
Marike van der Leeden, Rosalie J Huijsmans, Edwin Geleijn, Mariëtte de Rooij, Inge R Konings, Laurien M Buffart, Joost Dekker, Martijn M Stuiver
PURPOSE: Delivery of exercise interventions to patients with early-stage breast cancer undergoing chemotherapy requires complex clinical decisions. The purpose of this study was to develop a framework to support clinical decisions for tailoring exercise interventions to common comorbidities and cancer treatment-induced adverse effects. METHOD: Tailored exercise prescriptions were developed in four steps, following the i3-S strategy. All steps were based on current best available evidence, complemented with expert opinions...
January 5, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28028991/computed-tomography-based-quantitative-assessment-of-lower-extremity-lymphedema-following-treatment-for-gynecologic-cancer
#9
Ji Sung Yoo, Seung Hyun Chung, Myong Cheol Lim, Young Jae Kim, Kwang Gi Kim, Ji Hye Hwang, Yun Hee Kim
OBJECTIVE: To develop an algorithmic quantitative skin and subcutaneous tissue volume measurement protocol for lower extremity lymphedema (LEL) patients using computed tomography (CT), to verify the usefulness of the measurement techniques in LEL patients, and to observe the structural characteristics of subcutaneous tissue according to the progression of LEL in gynecologic cancer. METHODS: A program for algorithmic quantitative analysis of lower extremity CT scans has been developed to measure the skin and subcutaneous volume, muscle compartment volume, and the extent of the peculiar trabecular area with a honeycombed pattern...
December 7, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28003942/clinical-usage-and-economic-effectiveness-of-a-recently-developed-epidermal-autograft-harvesting-system-in-13-chronic-wound-patients-in-a-university-based-wound-center
#10
Angela Hulsey, Paul Linneman, Jeff Litt
INTRODUCTION:  Chronic wounds are a significant healthcare problem in the United States. Their costs approach 25 billion dollars in the United States. Current wound-care treatments of local wound care, moist dressings, and source control, while necessary for wound healing, are frequently not enough to ensure complete wound closure. The current surgical technique of split-thickness skin grafting is an operative procedure, painful, time-consuming, and leaves significant donor site wounds...
November 14, 2016: Curēus
https://www.readbyqxmd.com/read/28003769/chronic-radiation-induced-dermatitis-challenges-and-solutions
#11
REVIEW
Mateusz Spałek
Chronic radiation dermatitis is a late side effect of skin irradiation, which may deteriorate patients' quality of life. There is a lack of precise data about its incidence; however, several risk factors may predispose to the development of this condition. It includes radiotherapy dose, fractionation, technique, concurrent systemic therapy, comorbidities, and personal and genetic factors. Chronic radiation dermatitis is mostly caused by the imbalance of proinflammatory and profibrotic cytokines. Clinical manifestation includes changes in skin appearance, wounds, ulcerations, necrosis, fibrosis, and secondary cancers...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28000916/pathological-changes-of-adipose-tissue-in-secondary-lymphedema
#12
K Tashiro, J Feng, S-H Wu, T Mashiko, K Kanayama, M Narushima, H Uda, S Miyamoto, I Koshima, K Yoshimura
BACKGROUND: The pathophysiology of lymphedema is poorly understood. Current treatment options include compression therapy, resection, liposuction, and lymphatic microsurgery, but determining the optimal treatment approach for each patient remains challenging. OBJECTIVES: We characterized skin and adipose tissue alterations in the setting of secondary lymphedema. METHODS: Morphologic and histopathologic evaluations were conducted for 70 specimens collected from 26 female patients with lower extremity secondary lymphedema following surgical intervention for gynecologic cancers...
December 21, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/28000075/treatment-preferences-for-routine-lymphadenectomy-versus-no-lymphadenectomy-in-early-stage-endometrial-cancer
#13
Jung-Yun Lee, Kyunghoon Kim, Yun Shin Lee, Hyo Young Kim, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Jae Weon Kim, Young Tae Kim
BACKGROUND: Debate on the value of lymphadenectomy continues in endometrial cancer. The aim of this study was to investigate patient and clinician preferences for routine lymphadenectomy versus no lymphadenectomy in the surgical management of endometrial cancer. METHODS: A discrete choice experiment and trade-off question were designed and distributed to 103 endometrial cancer patients and 90 gynecologic oncologists. Participant preferences were quantified with regression analysis using scenarios based on three attributes: 5-year progression-free survival and the rates of acute and chronic complication...
December 20, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27993321/peripheral-magnetic-resonance-lymphangiography-techniques-and-applications
#14
REVIEW
Lee M Mitsumori, Elizabeth S McDonald, Peter C Neligan, Jeffrey H Maki
Peripheral lymphedema is a chronic progressive and debilitating disorder that results from abnormal lymphatic drainage. Advances in microsurgical techniques have led to the development of new treatment options for lymphedema that benefit from preoperative imaging to select the most appropriate surgical repair. Magnetic resonance (MR) lymphangiography is a noninvasive imaging modality capable of providing high-resolution 3D images of the lower extremities to define the severity and extent of lymphedema and depict individual lymphatic channels...
December 2016: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/27990192/long-term-results-of-innovative-procedure-in-surgical-management-of-chronic-lymphedema
#15
Seyed R Mousavi
BACKGROUND: Lymphedema is the result of impaired lymphatic drainage by the affected organ. This abnormality can be primary or secondary. Different operative approaches have been introduced to treat chronic lymphedema. MATERIALS AND METHODS: This retrospective study included 816 patients who were diagnosed with chronic lower extremity lymphedema and did not respond to non-operative management for at least six months. Data was collected over 25 years, between March 1987 and March 2013...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27986167/a-papulovesicular-eruption-associated-with-chronic-lymphedema-in-a-young-woman
#16
Tiffany J Herd, Rachel Teat Pflederer, Joseph Donald, Anand Rajpara
No abstract text is available yet for this article.
January 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27940507/titanium-dioxide-in-toothpaste-causing-yellow-nail-syndrome
#17
Ting-Yuan Hsu, Chun-Chen Lin, Ming-Dar Lee, Brian Pin-Hsuan Chang, Jeng-Daw Tsai
Yellow nail syndrome (YNS) is an uncommon disorder, the classic triad of which consists of yellow nails, lymphedema, and respiratory symptoms. Few pediatric cases have been reported. We report a 9-year-old girl with yellowish nail discoloration for 1 year accompanied by respiratory symptoms, including chronic cough, recurrent pneumonia, bronchiectasis, and chronic sinusitis. The patient was diagnosed with YNS. Knowing that a relationship between YNS and titanium has been reported, we collected her nail clippings and detected titanium in them by energy dispersive radiograph fluorescence...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/27930381/chronic-localized-fibrosing-leukocytoclastic-vasculitis-associated-with-lymphedema-intralymphatic-and-intravascular-lymphocytosis-and-chronic-myelogenous-leukemia-a-case-report-of-unilateral-erythema-elevatum-diutinum
#18
Juliana Atallah, Juan C Garces, Enrique Loayza, John A Carlson
One of the pathogenic causes of cutaneous inflammatory pseudotumors is chronic localized fibrosing leukocytoclastic vasculitis (CLFLCV), a vasculitic reaction pattern seen in granuloma faciale (GF), a localized vasculitis, and erythema elevatum diutinum (EED), a generalized vasculitis. Patients with myelodysplastic syndromes (MDSs) are at risk for a diverse spectrum of cutaneous neutrophilic dermatoses such as EED. Herein, we report a 74-year-old man who presented with a large ulcerative, fungating tumor affecting the right flexor ankle caused by CLFLCV...
December 7, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27920709/shoulder-pain-after-fall-septic-shock-and-pyomyositis-associated-with-breast-cancer-chemotherapy-and-lymphedema
#19
Hiromitsu Kitayama, Junko Sugiyama, Michiaki Hirayama, Yosihiro Onada, Yasushi Tsuji
BACKGROUND: As a symptom of pyomyositis, sepsis usually follows local inflammation signs. Here, we report pyomyositis with lymphedema of upper extremity in which septic shock and poor local findings initially presented during chemotherapy for breast cancer. CASE REPORT: An 80-year-old woman presented with chronic right shoulder pain during chemotherapy for the recurrent disease. She had a history of postmastectomy lymphedema, diabetes mellitus, and repeated hyaluronic acid injections to the shoulder joint...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27918865/evidence-based-practice-in-the-management-of-lower-limb-lymphedema-after-gynecological-cancer
#20
Lisandra Fossari Iwersen, Fabiana Flores Sperandio, Ariana Machado Toriy, Marina Palú, Clarissa Medeiros da Luz
PURPOSE: Lower limb lymphedema (LLL) is characterized as a physical-functional chronic complication that impacts the quality of life of women who have gone through treatment for gynecological cancer. The present study aims to check the conservative treatments available for lymphedema after gynecological cancer in the context of evidence-based practice. METHODS: The selection criteria included papers from May 1993 discussing treatment protocols used in LLL after treatment for gynecological cancer...
January 2017: Physiotherapy Theory and Practice
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