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Chronic lymphedema

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https://www.readbyqxmd.com/read/28901223/the-lymphatic-system-the-achilles-heel-of-the-fontan-kreutzer-circulation
#1
Christian Kreutzer, Guillermo Kreutzer
In spite of excellent long term survival the Fontan Kreutzer procedure commonly presents late failure due to end-organ damage. Several advances have been described to refine single ventricle management and surgical techniques. However, very little research has been dedicated to the lymphatic circulation in the precarious Fontan hemodynamic state. The lymphatic circulation is clearly affected since there is increased lymph production, which requires to be drained at a similar or higher pressure than it is produced, commonly resulting in chronic lymphedema...
September 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28894513/diagnostic-methods-risk-factors-prevention-and-management-of-breast-cancer-related-lymphedema-past-present-and-future-directions
#2
Hoda E Sayegh, Maria S Asdourian, Meyha N Swaroop, Cheryl L Brunelle, Melissa N Skolny, Laura Salama, Alphonse G Taghian
PURPOSE OF REVIEW: Breast cancer-related lymphedema (BCRL) is a chronic, adverse, and much feared complication of breast cancer treatment, which affects approximately 20% of patients following breast cancer treatment. BCRL has a tremendous impact on breast cancer survivors, including physical impairments and significant psychological consequences. The intent of this review is to discuss recent studies and analyses regarding the risk factors, diagnosis, prevention through early screening and intervention, and management of BCRL...
June 2017: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/28880710/serum-immune-proteins-in-limb-lymphedema-reflecting-tissue-processes-caused-by-lymph-stasis-and-chronic-dermatolymphangioadenitis-cellulitis
#3
Marzanna T Zaleska, Waldemar L Olszewski
BACKGROUND: Lymphedema of limbs affects a large mass of tissues. Pathological changes develop in skin and subcutaneous tissue. Bacterial retention in edema fluid is followed by chronic inflammatory reaction. The question arises whether the chronic processes affecting a large mass of limb tissues are reflected in the serum by appearance of specific proteins accumulating and subsequently absorbed from the lymphedematous tissues Aim: To measure the concentration of serum proteins (1) participating in cellular disintegration such as caspase 1, sFas, high-mobility group box 1 (HMGB1), and serpin, (2) cell growth regulating factors such as cortisol, human growth hormone, keratinocyte growth factor, and insulin-like growth factor (IGF), and (3) angiogenic and growth factors such as angiopoetins 1 and 2, adiponectin, leptin, and transforming growth factor beta...
September 7, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28838560/skin-tumors-arising-on-chronic-lymphedema
#4
I Latour-Álvarez, C Vázquez-Rodríguez, M García-Bustínduy
No abstract text is available yet for this article.
August 21, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28835898/chronic-effects-of-resistance-training-in-breast-cancer-survivors
#5
REVIEW
Wanderson Divino Nilo Dos Santos, Paulo Gentil, Rafael Felipe de Moraes, João Batista Ferreira Júnior, Mário Hebling Campos, Claudio Andre Barbosa de Lira, Ruffo Freitas Júnior, Martim Bottaro, Carlos Alexandre Vieira
Objective. To analyse effects of resistance training (RT) in breast cancer survivors (BCS) and how protocols and acute variables were manipulated. Methods. Search was made at PubMed, Science Direct, and LILACS. All articles published between 2000 and 2016 were considered. Studies that met the following criteria were included: written in English, Spanish, or Portuguese; BCS who have undergone surgery, chemotherapy, and/or radiotherapy; additional RT only; analysis of muscle performance, body mass composition (BMC), psychosocial parameters, or blood biomarkers...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28831632/utilization-of-bioimpedance-spectroscopy-in-the-prevention-of-chronic-breast-cancer-related-lymphedema
#6
David I Kaufman, Chirag Shah, Frank A Vicini, Marisa Rizzi
BACKGROUND: This analysis was performed to assess the impact of early intervention following prospective surveillance using bioimpedance spectroscopy (BIS) to detect and manage breast cancer-related lymphedema (BCRL). METHODS: From 8/2010 to 12/2016, 206 consecutive patients were evaluated with BIS. The protocol included pre-operative assessment with L-Dex as well as post-operative assessments at regular intervals. Patients with L-Dex scores >10 from baseline were considered to have subclinical BCRL and were treated with over-the-counter (OTC) compression sleeve for 4 weeks...
August 22, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28831342/diagnostic-accuracy-of-lymphoscintigraphy-for-lymphedema-and-analysis-of-false-negative-tests
#7
Aladdin H Hassanein, Reid A Maclellan, Frederick D Grant, Arin K Greene
Lymphedema is the chronic enlargement of tissue due to inadequate lymphatic function. Diagnosis is made by history and physical examination and confirmed with lymphoscintigraphy. The purpose of this study was to assess the accuracy of lymphoscintigraphy for the diagnosis of lymphedema and to determine characteristics of patients with false-negative tests. METHODS: Individuals referred to our lymphedema program with "lymphedema" between 2009 and 2016 were analyzed. Subjects were assessed by history, physical examination, and lymphoscintigraphy...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28818234/the-dutch-lymphedema-guidelines-based-on-the-international-classification-of-functioning-disability-and-health-and-the-chronic-care-model
#8
Robert J Damstra, Anne-Berth Halk
Lymphedema is a chronic and progressive condition due to an imbalance between lymphatic filtration and transport capacity. A relative overload of fluid is caused by lymphatic impairment (afterload impairment); an absolute overload is caused by increased filtration (preload raised). Lymphedema can result in considerable disability and loss of quality of life. The Dutch Society of Dermatology organized a task force to create guidelines using the International Classification of Functioning, Disability, and Health...
September 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28815344/long-term-survival-after-hematopoietic-stem-cell-transplantation-for-complete-stat1-deficiency
#9
Samuele Naviglio, Elena Soncini, Donatella Vairo, Arnalda Lanfranchi, Raffaele Badolato, Fulvio Porta
PURPOSE: Complete signal transducer and activator of transcription 1 (STAT1) deficiency is a rare autosomal recessive condition characterized by impairment of intracellular signaling from both type I and type II interferons (IFN). Affected patients are prone to early severe mycobacterial and viral infections, which usually result in death before 18 months of age. We previously reported a patient affected by complete STAT1 deficiency who underwent hematopoietic stem cell transplantation (HSCT)...
August 16, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28801716/-plastic-surgery-reconstruction-of-the-adult-buried-penis-option-or-obligation
#10
REVIEW
S Mühlstädt, P Anheuser, N Mohammed, A D Bach
The adult buried penis afflicts the patient with shame and is also potentially associated with considerable urogenital complications. Due to obesity, chronic urogenital lymphedema or subsequent inflammatory urogenital conditions, such as a lichen sclerosus et atrophicus, the clinical appearance of the adult buried penis is extremely variable. Epidemiological data are non-existent. Therapeutically, a combination of various plastic surgery procedures is often necessary for the best esthetic and functional results...
August 11, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28799015/risk-factors-of-pain-in-breast-cancer-survivors-a-systematic-review-and-meta-analysis
#11
REVIEW
Laurence Leysen, David Beckwée, Jo Nijs, Roselien Pas, Thomas Bilterys, Sofie Vermeir, Nele Adriaenssens
BACKGROUND: Breast cancer remains the number 1 lethal malignancy in women. With rising incidence and decreased mortality, the number of breast cancer survivors has increased. Consequently, sequelae, such as pain, are becoming more important. PURPOSE: The purpose of this study was to identify risk factors for the development of pain in breast cancer survivors. METHODS: PubMed and Web of Science were systematically screened for studies encompassing risk factors for the development of pain in breast cancer survivors...
August 10, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28795130/epithelioid-angiosarcoma-of-the-vulva-a-case-report
#12
S Yost, J Bradish, L Grossheim, A Hoekstra
•Vulvar angiosarcoma in a patient with pelvic radiation and chronic lymphedema•Epithelioid histologic staining positive for vimentin, ERG, CD31•Gross appearance of violaceous hyperpigmentation of the mons pubis.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28749744/investigating-the-short-term-effects-of-manual-lymphatic-drainage-and-compression-garment-therapies-on-lymphatic-function-using-near-infrared-imaging
#13
Catalina Lopera, Peter R Worsley, Dan L Bader, Deborah Fenlon
BACKGROUND: Lymphedema is a chronic peripheral swelling caused by a dysfunction of the lymphatic system, leading to discomfort and loss of upper limb movement. Therapies to treat or manage this swelling have limited evidence, partly because of a paucity in objective lymphatic measures. This study explored the role of near-infrared (NIR) imaging in evaluating interventions. METHODS: Nine healthy volunteers underwent NIR fluoroscopy using a microdose (50 μL, 0...
July 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28743274/risk-factors-and-a-prediction-model-for-lower-limb-lymphedema-following-lymphadenectomy-in-gynecologic-cancer-a-hospital-based-retrospective-cohort-study
#14
Kenji Kuroda, Yasuhiro Yamamoto, Manami Yanagisawa, Akira Kawata, Naoya Akiba, Kensuke Suzuki, Kazutoshi Naritaka
BACKGROUND: Lower limb lymphedema (LLL) is a chronic and incapacitating condition afflicting patients who undergo lymphadenectomy for gynecologic cancer. This study aimed to identify risk factors for LLL and to develop a prediction model for its occurrence. METHODS: Pelvic lymphadenectomy (PLA) with or without para-aortic lymphadenectomy (PALA) was performed on 366 patients with gynecologic malignancies at Yaizu City Hospital between April 2002 and July 2014; we retrospectively analyzed 264 eligible patients...
July 25, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28740950/lymphedema-from-diagnosis-to-treatment
#15
REVIEW
Oğuz Kayıran, Carolyn De La Cruz, Kaori Tane, Atilla Soran
Lymphedema is a chronic and progressive disorder resulting from impaired lymphatic system function. In developed countries, upper extremity lymphedema is mainly the consequence of breast cancer surgery in which axillary lymph node dissection and radiation alter upper extremity lymphatic flow. Diagnosis of lymphedema is made clinically. Nevertheless, there are numerous diagnostic tools available for disease staging. Recently, a new technology namely magnetic resonance lymphangiography has emerged in the medical field to assist in both diagnosis and management...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28739682/lower-body-lymphedema-in-patients-with-gynecologic-cancer
#16
REVIEW
Nicoletta Biglia, Valentina Zanfagnin, Alberto Daniele, Elisabetta Robba, Valentina E Bounous
Lower body lymphedema is a chronic condition and a significant cause of morbidity following treatment of gynecologic cancer that strongly impacts patients' quality of life (QoL). Most studies on secondary lymphedema have been performed on the upper limb after breast cancer treatment and much less is known about lower body lymphedema after gynecologic malignancies. This review focuses on secondary lymphedema due to gynecologic cancer treatment, analyzing its incidence in the different types of gynecologic cancer, diagnosis, risk factors, impact on QoL and treatment...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28705211/streptococcal-toxic-shock-syndrome-due-to-streptococcus-dysgalactiae-subspecies-equisimilis-in-breast-cancer-related-lymphedema-a-case-report
#17
Makoto Sumazaki, Fumi Saito, Hideaki Ogata, Miho Yoshida, Yorichika Kubota, Syunsuke Magoshi, Hironori Kaneko
BACKGROUND: Breast cancer-related lymphedema often causes cellulitis and is one of the most common complications after breast cancer surgery. Streptococci are the major pathogens underlying such cellulitis. Among the streptococci, the importance of the Lancefield groups C and G is underappreciated; most cases involve Streptococcus dysgalactiae subspecies equisimilis. Despite having a relatively weak toxicity compared with group A streptococci, Streptococcus dysgalactiae subspecies equisimilis is associated with a mortality rate that is as high as that of group A streptococci in cases of invasive infection because Streptococcus dysgalactiae subspecies equisimilis mainly affects elderly individuals who already have various comorbidities...
July 14, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28678084/magnetic-resonance-lymphography-at-9-4-t-using-a-gadolinium-based-nanoparticle-in-rats-investigations-in-healthy-animals-and-in-a-hindlimb-lymphedema-model
#18
Andreas Müller, Peter Fries, Bijan Jelvani, François Lux, Claudia E Rübe, Stephanie Kremp, Pietro Giovanoli, Arno Buecker, Michael D Menger, Matthias W Laschke, Florian S Frueh
OBJECTIVES: Magnetic resonance lymphography (MRL) in small animals is a promising but challenging tool in preclinical lymphatic research. In this study, we compared the gadolinium (Gd)-based nanoparticle AGuIX with Gd-DOTA for interstitial MRL in healthy rats and in a chronic rat hindlimb lymphedema model. MATERIALS AND METHODS: A comparative study with AGuIX and Gd-DOTA for interstitial MRL was performed in healthy Lewis rats (n = 6). For this purpose, 75 μL of 3 mM AGuIX (containing 30 mM Gd-DOTA side residues) and 75 μL 30 mM Gd-DOTA were injected simultaneously in the right and left hindlimbs...
July 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28662302/cost-of-illness-of-patients-with-lymphedema
#19
M Gutknecht, K Herberger, K Klose, S Purwins, D Dietz, C Blome, M Augustin
BACKGROUND: Chronic lymphedema is characterized by a continuous need for medical treatment, many comorbidities, and impaired quality of life. In Germany, about 4.5 million patients are affected by lymphedema. Thus, lymphedema causes high direct and indirect costs, even more in case of complications such as erysipelas and ulcers. OBJECTIVE: The aim of this study was to determinate the costs of illness of community lymphedema patients living in the metropolitan area of Hamburg, Germany...
June 29, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28654153/survivorship-and-the-chronic-cancer-patient-patterns-in-treatment-related-effects-follow-up-care-and-use-of-survivorship-care-plans
#20
Melissa A Frick, Carolyn C Vachani, Christina Bach, Margaret K Hampshire, Karen Arnold-Korzeniowski, James M Metz, Christine E Hill-Kayser
BACKGROUND: The survivorship needs of patients living with chronic cancer (CC) and their use of survivorship care plans (SCPs) have been overlooked and underappreciated. METHODS: A convenience sample of 39,088 SCPs completed for cancer survivors with an Internet-based SCP tool was examined; it included 5847 CC survivors (15%; CC was defined as chronic leukemia and/or recurrent/metastatic cancer of another nature). Patient-reported treatment effects and follow-up care patterns were compared between CC survivors and survivors treated with curative intent (CI)...
June 27, 2017: Cancer
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