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Recurrent uti

Albert S Lee, Diana K Bowen, Seth Vatsky, Stephen A Zderic, Gregory E Tasian
We report successful percutaneous nephrolithotomy (PCNL) in an 8-week-old, 4.12 kg infant with a combined stone burden of > 2 cm in a solitary kidney. The patient was born with thoracolumbar myelomeningocele and had developed recurrent urinary tract infections. Her size precluded retrograde intrarenal surgery and shockwave lithotripsy would be unlikely to clear the stone burden. Stone analysis revealed hydroxyapatite and carbonate apatite stones, and metabolic work up revealed hypercalciuria for which chlorothiazide was started...
June 2018: Canadian Journal of Urology
Vladimir Mouraviev, Michael McDonald
INTRODUCTION: The changing face of current infection phenotypes from planktonic to biofilm type has been developed implicating bacterial biofilms in recurrent infection. To date, no specific medical treatment exists to specifically target biofilms in the human host. Similarly, the identification of a biofilm has relied upon the analysis of tissue samples with electron microscopy or DNA identification with polymerase chain reaction (PCR) and sequencing. Standard culture and sensitivity test is not able to detect a presence of biofilms...
June 2018: Canadian Journal of Urology
Amy L Hamilton, Michael A Kamm, Siew C Ng, Mark Morrison
Proteus species, members of the Enterobacteriaceae family, are usually considered commensals in the gut and are most commonly recognized clinically as a cause of urinary tract infections. However, the recent identification of Proteus spp. as potential pathogens in Crohn's disease recurrence after intestinal resection serves as a stimulus to examine their potential role as gut pathogens. Proteus species possess many virulence factors potentially relevant to gastrointestinal pathogenicity, including motility; adherence; the production of urease, hemolysins, and IgA proteases; and the ability to acquire antibiotic resistance...
July 2018: Clinical Microbiology Reviews
John Schembri, Jonathan Bury, Lesley Hunt, Stuart Riley
BACKGROUND: Adenocarcinomas can arise in a variety of circumstances in which intestinal segments have been used for urinary diversions. Whereas ureterosigmoidostomy is the oldest and simplest form of continent urinary diversion it also seems to be the most dangerous in this regard. Herein we present a case of colonic neoplasia complicating a non-functioning ureterosigmoidostomy after 55 years; the longest latent period documented to date. CASE PRESENTATION: A 56-year-old lady born with congenital bladder exystrophy and who had a functional ileal conduit presented to us with a 6 month history of change in bowel habit and rectal bleeding...
June 14, 2018: BMC Gastroenterology
Astrid M van Strien, Patrick C Souverein, Carolina J P W Keijsers, Eibert R Heerdink, Hieronymus J Derijks, Rob J van Marum
BACKGROUND: Antipsychotic drugs are frequently prescribed to older adults, but they may be associated with serious adverse effects. The objective was to investigate the association between use of antipsychotics in older adults and the risk of urinary tract infections (UTIs). DESIGN: This study was designed as a cohort study. SETTING: Data were obtained from the Clinical Practice Research Datalink from January 1, 2000, to September 29, 2016...
June 9, 2018: Journal of Clinical Psychopharmacology
Alper Basbug, Alpaslan Yuksel, Aşkı Ellibeş Kaya
PURPOSE: We conducted a prospective randomized controlled trial to compare postoperative urinary catheter removal 2 versus 12 h after elective cesarean section in terms of irritative symptoms, first void time, incidence of urinary tract infection, postoperative mobilization time, and hospitalization time. METHODS: A total of 134 women admitted to Duzce University Hospital for primary or recurrent elective cesarean section were randomized into two groups. A total of 62 women were enrolled in the early group, with indwelling catheter removal 2 h after cesarean section; 74 women were enrolled in the delayed group, with catheter removal 12 h after cesarean section...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
S Pillai, S Govender
Chordoma is a rare malignant tumor with predilection for the sacrum. A favorable outcome depends on early diagnosis and surgical excision with tumor free margins. Aim: To review the incidence and prevalence of sacral chordoma and the appropriate surgical management and formulate a criteria for early diagnosis. Materials and methods: Thirty eight articles on the subject of sacral chordoma and extrapolated data of clinical and surgical significance. Results: The commonest presenting feature in patients with sacral chordoma was lower back pain which was worse on sitting and up to a third of these patients had associated urinary tract infections, constipation or symptoms of disc herniation...
June 2018: Journal of Orthopaedics
Çağla Serpil Doğan, Nevin Semerci Koyun, Gülşah Kaya Aksoy, Bülent Çekiç, Murat Savaş, Elif Çomak
OBJECTIVE: In this study, we aimed to assess renal outcomes of delayed diagnosis of dilating primary vesicoureteral reflux (VUR) following recurrent febrile urinary tract infections (fUTIs) and its diagnostic imaging procedures. MATERIAL AND METHODS: The medical records of patients who underwent ultrasonography (US), non- acute dimercaptosuccinic acid (Tc-99mDMSA) scintigraphy and voiding cystourethrography (VCUG), and who were older than 2 years at the time of VUR diagnosis were retrospectively reviewed...
May 31, 2018: Turkish Journal of Urology
Mario Lima, Michela Maffi, Niel Di Salvo, Giovanni Ruggeri, Michele Libri, Tommaso Gargano, Hubert Lardy
Persistent Müllerian duct syndrome is a disorder of sexual development, which features a failure of involution of Müllerian structures. An enlarged prostatic utricle is a kind of Müllerian duct remnant (MDR) with a tubular shaped structure communicating with the prostatic urethra. Treatment is aimed at relieving symptoms when present, preserve fertility and prevent neoplastic degeneration. We describe 3 cases of successful robot assisted-removal of symptomatic MDRs. The first case came to our attention for pseudo-incontinence; the other two for recurrent urinary tract infections...
May 30, 2018: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
Daniel W Nielsen, James S Klimavicz, Tia Cavender, Yvonne Wannemuehler, Nicolle L Barbieri, Lisa K Nolan, Catherine M Logue
Extraintestinal pathogenic Escherichia coli (ExPEC) include avian pathogenic E. coli (APEC), neonatal meningitis E. coli (NMEC), and uropathogenic E. coli (UPEC) and are responsible for significant animal and human morbidity and mortality. This study sought to investigate if biofilm formation by ExPEC likely contributes to these losses since biofilms are associated with recurrent urinary tract infections, antibiotic resistance, and bacterial exchange of genetic material. Therefore, the goal of this study was to examine differences in biofilm formation among a collection of ExPEC and to ascertain if there is a relationship between their ability to produce biofilms and their assignment to phylogenetic groups in three media types - M63, diluted TSB, and BHI...
2018: Frontiers in Microbiology
Young Ah Kim, Kyungwon Lee, Jae Eun Chung
BACKGROUND: Escherichia coli (E. coli) is known to cause urinary tract infection (UTI) and meningitis in neonates, as well as existing as a commensal flora of the human gut. Extended-spectrum β-lactamase (ESBL)-producing E. coli has increased in the community with the spread of CTX-M type ESBL-producing sequence type 131 (ST131)-O25-H30Rx E. coli clone. The role of ESBL-producing E. coli in female genital tract infection has not been elucidated. The clinical and molecular features of E...
June 1, 2018: BMC Infectious Diseases
Jonathan Cobley, Yih Chyn Phan, Wasim Mahmalji
Renal matrix stones are a rare phenomenon and they present a diagnostic challenge due to their atypical radiological appearances in comparison to more commonly encountered renal tract calculi. We describe a case of known stone former presenting with loin pain and recurrent urinary tract infections who was diagnosed with a matrix stone. The video of the diagnostic flexiureterorenoscopy demonstrating the matrix stone occupying almost the entire right renal collecting system is also presented.
2018: Case Reports in Urology
Angela Huttner, Veronica Gambillara
AIMS: In this "how it was done" narrative review, we provide a description of, and context for, the early development of a conjugate vaccine targeting extra-intestinal, pathogenic Escherichia coli (ExPEC), from its creation in the laboratory to its testing in a large, first-in-human phase Ib trial. SOURCES: We searched the Pubmed database for previous attempts to develop vaccines against ExPEC, and we provide data from laboratory and trial databases established during development of ExPEC4V, the tetravalent conjugate vaccine candidate...
May 24, 2018: Clinical Microbiology and Infection
İdris Kıvanç Cavıldak, Mehmet Çağlar Çakıcı, Nihat Karakoyunlu, Hamit Ersoy
Cystic nephroma is an unusual, cystic neoplasm of the kidney and is usually benign. There are two peaks in the incidence of the tumor, with a bimodal distribution presenting in children younger than two years old and in adults. These benign lesions are usually seen in childhood, whose clinical presentation is nonspecific with symptoms such as flank pain, hematuria and urinary tract infection. We aim to report treatment, and follow-up of a 48-year-old female patient with cystic nephroma for whom we performed open partial nephrectomy...
December 19, 2017: Turkish Journal of Urology
Hiroki Miyabayashi, Satoru Kumaki, Atsushi Sato, Ryoichi Onuma, Rie Noguchi, Taiki Sato, Takaya Metoki, Yohei Watanabe, Yusaku Tazawa, Masue Imaizumi, Setsuko Kitaoka
Hemophagoytic lymphohistiocytosis (HLH) is a rare life-threatening disorder caused by overactivation of the immune system, associated with infections, autoimmune disorders, and malignancies. The pathological hallmark of HLH is phagocytosis of blood cells and platelets by activated macrophages and histiocytes. In this report, we describe the onset of HLH in three children, aged 2, 5 and 7 years old, during the treatment of acute focal bacterial nephritis (AFBN) with an antibiotic, piperacillin-tazobactam (PIPC-TAZ)...
2018: Tohoku Journal of Experimental Medicine
Anna Lindblom, Nahid Karami, Tim Magnusson, Christina Åhrén
In clinical practice, there is a growing need to assess the impact of prior colonization or infection with extended-spectrum β-lactamase-producing Enterobacteriaceae (EPE) on new EPE infections. We have investigated the frequency of, and duration to, a subsequent EPE infection in patients with prior fecal carriage or infection with EPE. Culture data for 3272 EPE-positive patients in Western Sweden during 2004-2014 were evaluated. The median follow-up time was 3.7 years. The first recorded EPE-positive fecal screen, or clinical (urine, blood) culture, and subsequent EPE-positive clinical samples were analyzed, focusing on the first and last recurrence of EPE infection...
May 23, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Manuel Tinoco, Mélody Santos, Conceição Reitor, Andreia Rodrigues, João Monteiro
INTRODUCTION: Recurrent urinary tract infection is frequent and it is related to morbidity, costs and growing antibiotic resistance. OM 8930 vaccine is composed by Escherichia coli polysaccharide and it is a possible prophylactic measure, but there is doubt as to its effectiveness. MATERIAL AND METHODS: We performed a systematic review in evidence-based medicine databases with rigorous bibliography selection. RESULTS: We found an effective decrease of recurrences in test groups...
March 29, 2018: Acta Médica Portuguesa
Siobhan S Ennis, Huifang Guo, Lata Raman, Paul A Tambyah, Swaine L Chen, Ho Yee Tiong
OBJECTIVES: To examine the impact on quality of life of recurrent acute uncomplicated urinary tract infection among premenopausal Singaporean women, and to determine the risk factors for lower quality of life among these patients. METHODS: A total of 85 patients with recurrent acute uncomplicated urinary tract infection who were referred to the Urology Department at the National University Hospital, Singapore, were prospectively recruited over a 3-year period to complete the validated Short Form 36 Health Survey version 1...
May 22, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
Venkataseshan Jagannathan, Pragasam Viswanathan
Struvite or infection stones are one of the major clinical burdens among urinary tract infection, which occur due to the interaction between microbes and urine mineral components. Numerous urinary tract infection (UTI) causing microbes regulate through biofilm formation for survival from host defense, it is often found difficult in its eradication with simple anti-microbial agents and also the chance of recurrence and resistance development is significantly high. Cranberry consumption and maintenance of urinary tract health have been supported by clinical, epidemiological, and mechanistic studies...
May 18, 2018: Journal of Basic Microbiology
Pavankumar Rudrabhatla, Surendran Deepanjali, Jharna Mandal, Rathinam Palamalai Swaminathan, Tamilarasu Kadhiravan
OBJECTIVE: To evaluate whether stopping the effective antibiotic treatment following clinical improvement at Day 7 (Truncated treatment) would be non-inferior to continued treatment until Day 14 (Continued treatment) in patients with acute pyelonephritis (APN) requiring hospitalization treated with non-fluoroquinolone (non-FQ) antibiotics. METHODS: Hospitalized adult men and non-pregnant women with culture-confirmed APN were eligible for participation after they had clinically improved following empirical or culture-guided treatment with intravenous non-FQ antibiotic(s)...
2018: PloS One
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