keyword
MENU ▼
Read by QxMD icon Read
search

Performance validity testing

keyword
https://www.readbyqxmd.com/read/28239668/evaluation-of-cognitive-impairment-in-elderly-population-with-hypertension-from-a-low-resource-setting-agreement-and-bias-between-screening-tools
#1
María Lazo-Porras, María A Pesantes, J Jaime Miranda, Antonio Bernabe-Ortiz
INTRODUCTION: The evaluation of cognitive impairment in adulthood merits attention in societies in transition and especially in people with chronic diseases. Screening tools available for clinical practice and epidemiological studies have been designed in high-income but not in resource-constrained settings. The aim of this study was to assess the agreement and bias of three common tools used for screening of cognitive impairment in people with hypertension: the modified Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and the Leganés Cognitive Test (LCT)...
December 2016: ENeurologicalSci
https://www.readbyqxmd.com/read/28239609/application-of-taxonomic-modeling-to-microbiota-data-mining-for-detection-of-helminth-infection-in-global-populations
#2
Mahbaneh Eshaghzadeh Torbati, Makedonka Mitreva, Vanathi Gopalakrishnan
Human microbiome data from genomic sequencing technologies is fast accumulating, giving us insights into bacterial taxa that contribute to health and disease. The predictive modeling of such microbiota count data for the classification of human infection from parasitic worms, such as helminths, can help in the detection and management across global populations. Real-world datasets of microbiome experiments are typically sparse, containing hundreds of measurements for bacterial species, of which only a few are detected in the bio-specimens that are analyzed...
December 2016: Data (Basel)
https://www.readbyqxmd.com/read/28239342/informative-cues-facilitate-saccadic-localization-in-blindsight-monkeys
#3
Masatoshi Yoshida, Ziad M Hafed, Tadashi Isa
Patients with damage to the primary visual cortex (V1) demonstrate residual visual performance during laboratory tasks despite denying having a conscious percept. The mechanisms behind such performance, often called blindsight, are not fully understood, but the use of surgically-induced unilateral V1 lesions in macaque monkeys provides a useful animal model for exploring such mechanisms. For example, V1-lesioned monkeys localize stimuli in a forced-choice condition while at the same time failing to report awareness of identical stimuli in a yes-no detection condition, similar to human patients...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28238947/identification-of-novel-mrp3-inhibitors-based-on-computational-models-and-validation-using-an-in-vitro-membrane-vesicle-assay
#4
Izna Ali, Matthew A Welch, Yang Lu, Peter W Swaan, Kim L R Brouwer
INTRODUCTION: Multidrug resistance-associated protein 3 (MRP3), an efflux transporter on the hepatic basolateral membrane, may function as a compensatory mechanism to prevent the accumulation of anionic substrates (e.g., bile acids) in hepatocytes. Inhibition of MRP3 may disrupt bile acid homeostasis and is one hypothesized risk factor for the development of drug-induced liver injury (DILI). Therefore, identifying potential MRP3 inhibitors could help mitigate the occurrence of DILI. METHODS: Bayesian models were developed using MRP3 transporter inhibition data for 86 structurally diverse drugs...
February 23, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28238815/measurement-of-functional-cognition-and-complex-everyday-activities-in-older-adults-with-mild-cognitive-impairment-and-mild-dementia-validity-of-the-large-allen-s-cognitive-level-screen
#5
Jacqueline Wesson, Lindy Clemson, John D Crawford, Nicole A Kochan, Henry Brodaty, Simone Reppermund
OBJECTIVE: To explore the validity of the Large Allen's Cognitive Level Screen-5 (LACLS-5) as a performance-based measure of functional cognition, representing an ability to perform complex everyday activities in older adults with mild cognitive impairment (MCI) and mild dementia living in the community. METHODS: Using cross-sectional data from the Sydney Memory and Ageing Study, 160 community-dwelling older adults with normal cognition (CN; N = 87), MCI (N = 43), or dementia (N = 30) were studied...
January 4, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28238803/discovery-and-characterization-of-eiib-a-new-%C3%AE-conotoxin-from-conus-ermineus-venom-by-nachrs-affinity-capture-monitored-by-maldi-tof-tof-mass-spectrometry
#6
Julien Echterbille, Nicolas Gilles, Romulo Araóz, Gilles Mourier, Muriel Amar, Denis Servent, Edwin De Pauw, Loic Quinton
Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α-conotoxins, a family of peptide toxins produced by venomous cone snails. nAChRs are implicated in numerous physiological processes explaining why the design of new pharmacological tools and the discovery of potential innovative drugs targeting these receptor channels appear so important. This work describes a methodology developed to discover new ligands of nAChRs from complex mixtures of peptides...
February 23, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28238345/anastomotic-leak-after-colorectal-resection-a-population-based-study-of-risk-factors-and-hospital-variation
#7
Vahagn C Nikolian, Neil S Kamdar, Scott E Regenbogen, Arden M Morris, John C Byrn, Pasithorn A Suwanabol, Darrell A Campbell, Samantha Hendren
BACKGROUND: Anastomotic leak is a major source of morbidity in colorectal operations and has become an area of interest in performance metrics. It is unclear whether anastomotic leak is associated primarily with surgeons' technical performance or explained better by patient characteristics and institutional factors. We sought to establish if anastomotic leak could serve as a valid quality metric in colorectal operations by evaluating provider variation after adjusting for patient factors...
February 18, 2017: Surgery
https://www.readbyqxmd.com/read/28238283/supporting-skill-acquisition-in-cochlear-implant-surgery-through-virtual-reality-simulation
#8
Bridget Copson, Sudanthi Wijewickrema, Yun Zhou, Patorn Piromchai, Robert Briggs, James Bailey, Gregor Kennedy, Stephen O'Leary
OBJECTIVES: To evaluate the effectiveness of a virtual reality (VR) temporal bone simulator in training cochlear implant surgery. METHODS: We compared the performance of 12 otolaryngology registrars conducting simulated cochlear implant surgery before (pre-test) and after (post-tests) receiving training on a VR temporal bone surgery simulator with automated performance feedback. The post-test tasks were two temporal bones, one that was a mirror image of the temporal bone used as a pre-test and the other, a novel temporal bone...
March 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28237952/factors-associated-with-hospitalisations-in-chronic-conditions-deemed-avoidable-ecological-study-in-the-spanish-healthcare-system
#9
Ester Angulo-Pueyo, Manuel Ridao-López, Natalia Martínez-Lizaga, Sandra García-Armesto, Salvador Peiró, Enrique Bernal-Delgado
OBJECTIVES: Potentially avoidable hospitalisations have been used as a proxy for primary care quality. We aimed to analyse the ecological association between contextual and systemic factors featured in the Spanish healthcare system and the variation in potentially avoidable hospitalisations for a number of chronic conditions. METHODS: A cross-section ecological study based on the linkage of administrative data sources from virtually all healthcare areas (n=202) and autonomous communities (n=16) composing the Spanish National Health System was performed...
February 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28237830/a-need-to-revisit-clinical-breakpoints-of-tigecycline-effect-of-atypical-non-linear-plasma-protein-binding
#10
Ravi Shankar Prasad Singh, Jatinder Kaur Mukker, Stefanie K Drescher, Amelia N Deitchman, Hartmut Derendorf
Tigecycline is highly active against various drug-resistant bacteria. The US Food and Drug Administration (FDA) recently issued a black box warning for tigecycline owing to an associated increase in all-cause mortality. Clinical breakpoints of antibiotics are vital in susceptibility testing of pathogens for the selection of antibiotic therapy; however, no consensus exists between different committees on the clinical breakpoints of tigecycline. Of note, tigecycline exhibits atypical non-linear plasma protein binding (PPB) behaviour, and the pivotal probability of target attainment (PTA) analysis for the determination of clinical breakpoints did not account for the PPB of tigecycline...
February 22, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28237588/evaluating-a-commercial-pcr-assay-against-bacterial-culture-for-diagnosing-streptococcus-uberis-and-staphylococcus-aureus-throughout-lactation
#11
N M Steele, J H Williamson, R Thresher, R A Laven, J E Hillerton
The performance of a commercial, real-time PCR assay was compared with traditional bacterial culture for the identification of Streptococcus uberis and Staphylococcus aureus in bovine milk collected at different stages of lactation. Initial validation tests using fresh and frozen quarter milk samples identified factors that affected the success of the PCR. Therefore, the standard protocol was adjusted for samples collected at the first milking postpartum (colostrum) and from clinical mastitis cases. The adjustment involved PCR testing both undiluted and diluted (1 in 10 with sterile water) DNA extracts...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28237401/unraveling-biophysical-interactions-of-radiation-pneumonitis-in-non-small-cell-lung-cancer-via-bayesian-network-analysis
#12
Yi Luo, Issam El Naqa, Daniel L McShan, Dipankar Ray, Ines Lohse, Martha M Matuszak, Dawn Owen, Shruti Jolly, Theodore S Lawrence, Feng-Ming Spring Kong, Randall K Ten Haken
BACKGROUND: In non-small-cell lung cancer radiotherapy, radiation pneumonitis≥grade 2 (RP2) depends on patients' dosimetric, clinical, biological and genomic characteristics. METHODS: We developed a Bayesian network (BN) approach to explore its potential for interpreting biophysical signaling pathways influencing RP2 from a heterogeneous dataset including single nucleotide polymorphisms, micro RNAs, cytokines, clinical data, and radiation treatment plans before and during the course of radiotherapy...
February 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28237400/individualized-early-death-and-long-term-survival-prediction-after-stereotactic-radiosurgery-for-brain-metastases-of-non-small-cell-lung-cancer-two-externally-validated-nomograms
#13
Jaap D Zindler, Arthur Jochems, Frank J Lagerwaard, Rosemarijne Beumer, Esther G C Troost, Daniëlle B P Eekers, Inge Compter, Peter-Paul van der Toorn, Marion Essers, Bing Oei, Coen W Hurkmans, Anna M E Bruynzeel, Geert Bosmans, Ans Swinnen, Ralph T H Leijenaar, Philippe Lambin
INTRODUCTION: Commonly used clinical models for survival prediction after stereotactic radiosurgery (SRS) for brain metastases (BMs) are limited by the lack of individual risk scores and disproportionate prognostic groups. In this study, two nomograms were developed to overcome these limitations. METHODS: 495 patients with BMs of NSCLC treated with SRS for a limited number of BMs in four Dutch radiation oncology centers were identified and divided in a training cohort (n=214, patients treated in one hospital) and an external validation cohort n=281, patients treated in three other hospitals)...
February 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28237075/rasch-analysis-indicates-that-the-simple-shoulder-test-is-robust-but-minor-item-modifications-and-attention-to-gender-differences-should-be-considered
#14
Jayaprakash Raman, Joy C MacDermid, David Walton, George S Athwal
STUDY DESIGN: Repeated cross-sectional study. INTRODUCTION: Multiple studies have evaluated the psychometric properties of the Simple Shoulder Test (SST) through traditional methods supporting it as valid and reliable. Since the evidentiary pool supporting the use of the SST has only partially addressed key measurement properties and the development of SST pre-dates the common use of Rasch model, validation of SST has become a necessity to establish as a reliable and valid PRO for shoulder conditions...
February 22, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28236994/-electroconvulsive-therapy-and-level-of-evidence-from-causality-to-dose-effect-relationship
#15
J-A Micoulaud-Franchi, C Quilès, M Cermolacce, R Belzeaux, M Adida, E Fakra, J-M Azorin
OBJECTIVES: The first objective of this article is to summarize the history of electroconvulsive therapy (ECT) in psychiatry in order to highlight the transition from clinical level of evidence based on phenomenological descriptions to controlled trial establishing causal relationship. The second objective is to apply the criteria of causation for ECT, to focus on the dose-effect relationship criteria, and thus to analyze the conditions of application of these criteria for ECT. METHODS: A literature review exploring the use of electricity, ECT and electroencephalography (EEG) in psychiatry was conducted...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/28236991/-how-to-assess-curative-and-or-preventive-effects-of-psychotropic-drugs
#16
T Bottai, D Pringuey, R Belzeaux, M Adida, J-M Azorin
Proving the efficacy of a psychotropic drug is a medical, scientific and ethical need. Psychotropic drug development is now a highly complex process, which takes several years and which is very expensive. It involves multiple steps of preclinical and clinical pharmacological refinement and testing. Methodology of studies to prove curative or preventive effect of psychotropic drugs is well codified. Preclinical studies include pharmacokinetic data, toxicology and performance in various animal models of pathology...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/28236625/serum-prolactin-revisited-parametric-reference-intervals-and-cross-platform-evaluation-of-polyethylene-glycol-precipitation-based-methods-for-discrimination-between-hyperprolactinemia-and-macroprolactinemia
#17
Martin Overgaard, Susanne Møller Pedersen
BACKGROUND: Hyperprolactinemia diagnosis and treatment is often compromised by the presence of biologically inactive and clinically irrelevant higher-molecular-weight complexes of prolactin, macroprolactin. The objective of this study was to evaluate the performance of two macroprolactin screening regimes across commonly used automated immunoassay platforms. METHODS: Parametric total and monomeric gender-specific reference intervals were determined for six immunoassay methods using female (n=96) and male sera (n=127) from healthy donors...
February 25, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28236183/validation-of-a-google-street-view-based-neighborhood-disorder-observational-scale
#18
Miriam Marco, Enrique Gracia, Manuel Martín-Fernández, Antonio López-Quílez
Recently, there has been a growing interest in developing new tools to measure neighborhood features using the benefits of emerging technologies. This study aimed to assess the psychometric properties of a neighborhood disorder observational scale using Google Street View (GSV). Two groups of raters conducted virtual audits of neighborhood disorder on all census block groups (N = 92) in a district of the city of Valencia (Spain). Four different analyses were conducted to validate the instrument. First, inter-rater reliability was assessed through intraclass correlation coefficients, indicating moderated levels of agreement among raters...
February 24, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28236027/validation-of-the-custo-screen-pediatric-blood-pressure-monitor-according-to-the-european-society-of-hypertension-international-protocol-revision-2010
#19
Beate Beime, Cornelia Deutsch, Ralf Krüger, Andreas Wolf, Peter Müller, Gertrud Hammel, Peter Bramlage
: The purpose of the study was to validate the ambulatory blood pressure monitoring (ABPM) device custo screen pediatric in children aged 3 to 12 years according to the International Protocol of the European Society of Hypertension (ESH-IP revision 2010). Thirty-three children were included and systolic and diastolic blood pressure measurements were performed according to the ESH-IP. The protocol was modified for children considering data from the German Health Interview and Examination Survey for Children and Adolescents (KIGGS)...
February 24, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28235724/eeg-synchronization-measures-are-early-outcome-predictors-in-comatose-patients-after-cardiac-arrest
#20
Frédéric Zubler, Andreas Steimer, Rebekka Kurmann, Mojtaba Bandarabadi, Jan Novy, Heidemarie Gast, Mauro Oddo, Kaspar Schindler, Andrea O Rossetti
OBJECTIVE: Outcome prognostication in comatose patients after cardiac arrest (CA) remains a major challenge. Here we investigated the prognostic value of combinations of linear and non-linear bivariate EEG synchronization measures. METHODS: 94 comatose patients with EEG within 24h after CA were included. Clinical outcome was assessed at 3months using the Cerebral Performance Categories (CPC). EEG synchronization between the left and right parasagittal, and between the frontal and parietal brain regions was assessed with 4 different quantitative measures (delta power asymmetry, cross-correlation, mutual information, and transfer entropy)...
February 5, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
keyword
keyword
67504
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"