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Performance validity testing

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https://www.readbyqxmd.com/read/29166182/increasing-confidence-and-ability-in-implementing-kangaroo-mother-care-method-among-young-mothers
#1
Eleni Kenanga Purbasary, Yeni Rustina, Tri Budiarti
Mothers giving birth to low birth weight babies (LBWBs) have low confidence in caring for their babies because they are often still young and may lack the knowledge, experience, and ability to care for the baby. This research aims to determine the effect of education about kangaroo mother care (KMC) on the confidence and ability of young mothers to implement KMC. The research methodology used was a controlled-random experimental approach with pre- and post-test equivalent groups of 13 mothers and their LBWBs in the intervention group and 13 mothers and their LBWBs in the control group...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29165869/canagliflozin-stability-study-and-eco-friendly-chromatographic-determination-of-its-degradation-product-a-comparative-study
#2
Aml A Emam
Canagliflozin is a newly approved drug for type II diabetes mellitus. A full stability study of Canagliflozin was performed following international conference on harmonization strategies. The drug was stable against all conditions except oxidation where only one degradation product was separated and structurally elucidated using mass spectrometry and IR spectroscopy. A green high-performance thin-layer chromatographic densitometric determination was developed and validated for the accurate quantification of Canagliflozin and its main oxidative degradation product...
November 22, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29165831/external-validation-of-the-ita-li-ca-prognostic-system-for-patients-with-hepatocellular-carcinoma-a-multicenter-cohort-study-hep-17-0903
#3
Mauro Borzio, Elena Dionigi, Angelo Rossini, Massimo Marignani, Rodolfo Sacco, Ilario De Sio, Emanuela Bertolini, Giampiero Francica, Anna Giacomin, Giancarlo Parisi, Susanna Vicari, Anna Toldi, Andrea Salmi, Sergio Boccia, Mario Mitra, Fabio Fornari
Several staging systems for HCC have been developed. BCLC is considered the best in predicting survival, although limitations have emerged. Recently the Italian-Liver-Cancer (ITA.LI.CA) prognostic system, integrating the ITA.LI.CA tumor-staging (stages 0, A, B1-3; C) with Child-Pugh score, ECOG-PST, and AFP with a strong ability to predict survival was proposed. Aim of our study was to provide an external validation of the ITA.LI.CA system in an independent real-life occidental cohort of HCCs. METHODS: From September 2008 to April 2016, 1508 cirrhotics with incident HCC were consecutively enrolled in 27 Italian institutions (EpaHCC multi-institutional cohort)...
November 22, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29165716/targeting-bcr-abl-independent-tki-resistance-in-chronic-myeloid-leukemia-by-mtor-and-autophagy-inhibition
#4
Rebecca Mitchell, Lisa E M Hopcroft, Pablo Baquero, Elaine K Allan, Kay Hewit, Daniel James, Graham Hamilton, Arunima Mukhopadhyay, Jim O'Prey, Alan Hair, Junia V Melo, Edmond Chan, Kevin M Ryan, Véronique Maguer-Satta, Brian J Druker, Richard E Clark, Subir Mitra, Pawel Herzyk, Franck E Nicolini, Paolo Salomoni, G Vignir Helgason
Background: Imatinib and second-generation tyrosine kinase inhibitors (TKIs) nilotinib and dasatinib have statistically significantly improved the life expectancy of chronic myeloid leukemia (CML) patients; however, resistance to TKIs remains a major clinical challenge. Although ponatinib, a third-generation TKI, improves outcomes for patients with BCR-ABL-dependent mechanisms of resistance, including the T315I mutation, a proportion of patients may have or develop BCR-ABL-independent resistance and fail ponatinib treatment...
November 20, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29165641/how-to-do-or-not-to-do-%C3%A2-measuring-health-worker-motivation-in-surveys-in-low-and-middle-income-countries
#5
J Borghi, J Lohmann, E Dale, F Meheus, J Goudge, K Oboirien, A Kuwawenaruwa
A health system's ability to deliver quality health care depends on the availability of motivated health workers, which are insufficient in many low income settings. Increasing policy and researcher attention is directed towards understanding what drives health worker motivation and how different policy interventions affect motivation, as motivation is key to performance and quality of care outcomes. As a result, there is growing interest among researchers in measuring motivation within health worker surveys...
November 20, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29165533/muscle-quality-strength-and-lower-extremity-physical-performance-in-the-baltimore-longitudinal-study-of-aging
#6
N Chiles Shaffer, E Fabbri, L Ferrucci, M Shardell, E M Simonsick, S Studenski
BACKGROUND: Muscle quality is defined as the force generated by each volumetric unit of muscle tissue. No consensus exists on an optimal measure of muscle quality, impeding comparison across studies and implementation in clinical settings. It is unknown whether muscle quality measures that rely on complex and expensive tests, such as isokinetic dynamometry and computerized tomography correlate with lower extremity performance (LEP) any better than measures derived from simpler and less expensive tests, such as grip strength (Grip) and appendicular lean mass (ALM) assessed by DXA...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29165509/-evaluation-of-xpert%C3%A2-mtb-rif-technique-for-mycobacterium-tuberculosis-complex-detection-in-extra-respiratory-specimens
#7
Patricia García, M Elvira Balcells, Claudia Castillo, Carolina Miranda, Enrique Geoffroy, Juan C Román, Aniela Wozniak
Extra-pulmonary tuberculosis (TB) represents the 26.2% of total TB cases in Chile. Culture is the gold standard method, but the process is extremely slow. Xpert®MTB/RIF technique detects Mycobacterium tuberculosis complex (MTBc) through real time PCR in less than 3 h. However, it has been validated only for respiratory specimens. We aimed to determine the performance of Xpert®MTB/RIF test in detecting MTBc in extra-respiratory specimens compared with a combined gold standard consisting in a positive (liquid and solid) mycobacterial culture and/or a positive validated molecular method (q-RPC, Cobas®TaqMan®-MTB)...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29165334/development-and-validation-of-an-on-line-water-toxicity-sensor-with-immobilized-luminescent-bacteria-for-on-line-surface-water-monitoring
#8
Marjolijn Woutersen, Bram van der Gaag, Afua Abrafi Boakye, Jan Mink, Robert S Marks, Arco J Wagenvoort, Henk A M Ketelaars, Bram Brouwer, Minne B Heringa
Surface water used for drinking water production is frequently monitored in The Netherlands using whole organism biomonitors, with for example Daphnia magna or Dreissena mussels, which respond to changes in the water quality. However, not all human-relevant toxic compounds can be detected by these biomonitors. Therefore, a new on-line biosensor has been developed, containing immobilized genetically modified bacteria, which respond to genotoxicity in the water by emitting luminescence. The performance of this sensor was tested under laboratory conditions, as well as under field conditions at a monitoring station along the river Meuse in The Netherlands...
November 22, 2017: Sensors
https://www.readbyqxmd.com/read/29165287/quantitative-evaluation-of-head-and-neck-cancer-treatment-related-dysphagia-in-the-development-of-a-personalized-treatment-deintensification-paradigm
#9
Harry Quon, Xuan Hui, Zhi Cheng, Scott Robertson, Luke Peng, Michael Bowers, Joseph Moore, Amanda Choflet, Alex Thompson, Mariah Muse, Ana Kiess, Brandi Page, Carole Fakhry, Christine Gourin, Jolyne O'Hare, Peter Graham, Michal Szczesniak, Julia Maclean, Ian Cook, Todd McNutt
PURPOSE: To test the hypothesis that quantifying swallow function with multiple patient-reported outcome (PRO) instruments is an important strategy to yield insights in the development of personalized deintensified therapies seeking to reduce the risk of head and neck cancer (HNC) treatment-related dysphagia (HNCTD). METHODS AND MATERIALS: Irradiated HNC subjects seen in follow-up care (April 2015 to December 2015) who prospectively completed the Sydney Swallow Questionnaire (SSQ) and the MD Anderson Dysphagia Inventory (MDADI) concurrently on the web interface to our Oncospace database were evaluated...
December 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29165105/a-behavioral-strategy-to-minimize-air-pollution-exposure-in-pregnant-women-a-randomized-controlled-trial
#10
Marzieh Araban, Sedigheh Sadat Tavafian, Saeed Motesaddi Zarandi, Ali Reza Hidarnia, Andrea Burri, Ali Montazeri
BACKGROUND: Pregnant women and their fetus belong to a sensitive group in response to air pollution hazards. The aim of this study was to evaluate the effectiveness of a theory-based educational program to change pollution exposure behavior in pregnant women. METHODS: In this randomized controlled trial, pregnant women attending a prenatal clinic in Tehran, Iran were selected and randomized into the experimental and control groups. The inclusion criteria were age between 18 and 35 years, having a history of pregnancies without adverse outcomes and not suffering from chronic diseases...
April 4, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165079/comparison-of-clobetasol-propionate-generics-using-simplified-in-vitro-bioequivalence-method-for-topical-drug-products
#11
Kelen Carine Costa Soares, Weidson Carlos de Souza, Leonardo de Souza Texeira, Marcilio Sergio Soares da Cunha-Filho, Guilherme Martins Gelfuso, Tais Gratieri
The aim of this paper is to propose a simple in vitro skin penetration experiment in which the drug is extracted from the whole skin piece as a test valid for formulation screening and optimization during development process, equivalence assessment during quality control or post-approval after changes to the product. Twelve clobetasol propionate (CP) formulations (six creams and six ointments) from the local market were used as a model to challenge the proposed methodology in comparison to in vitro skin penetration following tape-stripping for drug extraction...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29164792/validity-and-correlates-of-the-international-physical-activity-questionnaire-in-first-episode-psychosis
#12
Davy Vancampfort, Marc De Hert, Inez Myin-Germeys, Simon Rosenbaum, Brendon Stubbs, Tine Van Damme, Michel Probst
AIM: The International Physical Activity Questionnaire (IPAQ) is a self-report tool commonly used in mental healthcare settings to assess physical activity. However, its validity has not yet been investigated in first-episode psychosis (FEP). The aim of this study was to examine the concurrent validity of the IPAQ compared with an objective real-life measure, the Sensewear Armband (SWA), in assessing moderate and vigorous physical activity (MVPA) in people with FEP. A secondary aim was to explore whether there are differences in correlates of the IPAQ vs SWA scores...
November 22, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29164646/b-factor-profile-prediction-for-rna-flexibility-using-support-vector-machines
#13
Ivantha Guruge, Ghazaleh Taherzadeh, Jian Zhan, Yaoqi Zhou, Yuedong Yang
Determining the flexibility of structured biomolecules is important for understanding their biological functions. One quantitative measurement of flexibility is the atomic Debye-Waller factor or temperature B-factor. Most existing studies are limited to temperature B-factors of proteins and their prediction. Only one method attempted to predict temperature B-factors of ribosomal RNA. Here, we developed and compared machine-learning techniques in prediction of temperature B-factors of RNAs. The best model based on Support Vector Machines yields Pearson's correction coefficient at 0...
November 21, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29164634/testing-the-limits-of-model-membrane-simulations-bilayer-composition-and-pressure-scaling
#14
Nikoleta Ivanova, Anela Ivanova
Studying transfer of bioactive compounds across cell membranes by simulations attracts growing attention. To perform such calculations accurately, it is necessary to verify the validity of computational protocols established for description of unperturbed lipid bilayers also with translocating substances present. The current work reports the results from 1 μs long atomistic molecular dynamics simulations of two types of model plasma membranes-one built of a single phospholipid (DPPC) and one constructed of four types of phospholipids-in the presence of a drug-peptide complex experimentally known to cross cell membranes...
November 21, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29164630/segmentation-and-tracking-of-lung-nodules-via-graph-cuts-incorporating-shape-prior-and-motion-from-4-d-ct
#15
Jungwon Cha, Mohammad Mehdi Farhangi, Neal Dunlap, Amir A Amini
PURPOSE: We have developed a robust tool for performing volumetric and temporal analysis of nodules from respiratory gated 4-D CT. The method could prove useful in IMRT of lung cancer. METHODS: We modified the conventional graph cuts method by adding an adaptive shape prior as well as motion information within a signed distance function representation to permit more accurate and automated segmentation and tracking of lung nodules in 4-D CT data. Active shape models (ASM) with signed distance function were used to capture the shape prior information, preventing unwanted surrounding tissues from becoming part of the segmented object...
November 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/29163153/ketogal-a-derivative-ketorolac-molecule-with-minor-ulcerogenic-and-renal-toxicity
#16
Roberto Russo, Carmen De Caro, Bice Avallone, Salvatore Magliocca, Maria Nieddu, Gianpiero Boatto, Roberta Troiano, Rosario Cuomo, Carla Cirillo, Carmen Avagliano, Claudia Cristiano, Giovanna La Rana, Giovanni Sarnelli, Antonio Calignano, Maria G Rimoli
Ketorolac is a powerful non-steroidal anti-inflammatory drug (NSAID), with a great analgesic activity, present on the Italian market since 1991. Despite the excellent therapeutic activity, the chronic use of ketorolac has long been limited owing to the high incidence of gastrointestinal and kidney side events. In our previous study, we demonstrated that ketorolac-galactose conjugate (ketogal), synthesized and tested in a single-dose study, was able to reduce ulcerogenicity, while preserving the high pharmacological efficacy of its parent drug...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163089/the-bachd-rat-model-of-huntington-disease-shows-specific-deficits-in-a-test-battery-of-motor-function
#17
Giuseppe Manfré, Erik K H Clemensson, Elisavet I Kyriakou, Laura E Clemensson, Johanneke E van der Harst, Judith R Homberg, Huu Phuc Nguyen
Rationale: Huntington disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive and neuropsychiatric symptoms. HD is usually diagnosed by the appearance of motor deficits, resulting in skilled hand use disruption, gait abnormality, muscle wasting and choreatic movements. The BACHD transgenic rat model for HD represents a well-established transgenic rodent model of HD, offering the prospect of an in-depth characterization of the motor phenotype. Objective: The present study aims to characterize different aspects of motor function in BACHD rats, combining classical paradigms with novel high-throughput behavioral phenotyping...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29162475/-thyrotropin-reference-ranges-during-pregnancy-in-the-province-of-huelva-spain
#18
A Ortega Carpio, I Vázquez Rico, M A Castaño López, L Duarte González, M Montilla Álvaro, A Ruiz Reina
OBJECTIVE: The correct diagnosis of hypothyroidism during pregnancy requires knowledge of the local trimester-specific thyrotropin (TSH) reference ranges. When these are not available, the guidelines recommend upper limits of 2.5, 3.0, and 3.0μU/ml for the 1(st), 2(nd), and 3(rd) trimesters, respectively. The aim is to establish the reference range for our local population. MATERIAL AND METHODS: A population-based observational study was performed on healthy pregnant women from 11 healthcare centres in the province of Huelva...
November 18, 2017: Semergen
https://www.readbyqxmd.com/read/29162377/smartphone-based-accelerometry-is-a-valid-tool-for-measuring-dynamic-changes-in-knee-extension-range-of-motion
#19
Morten Pallisgaard Støve, Thorvaldur Skuli Palsson, Rogerio Pessoto Hirata
INTRODUCTION: Measurement of static joint range of motion is used extensively in orthopaedic and rehabilitative communities to benchmark treatment efficacy. Static measures are, however, insufficient in providing detailed information about patient impairments. Dynamic range of motion measures could provide more detailed information about patient impairments thus leading to better clinical assessments. Reliable and valid methods are available, but due to limitations in the present technology, dynamic measures are seldom performed in clinical settings...
November 18, 2017: Knee
https://www.readbyqxmd.com/read/29162332/integrating-downstaging-in-the-risk-assessment-of-patients-with-locally-advanced-rectal-cancer-treated-with-neoadjuvant-chemoradiotherapy-validation-of-valentini-s-nomograms-and-the-neoadjuvant-rectal-score
#20
Susana Roselló, Matteo Frasson, Eduardo García-Granero, Desamparados Roda, Esther Jordá, Samuel Navarro, Salvador Campos, Pedro Esclápez, Stephanie García-Botello, Blas Flor, Alejandro Espí, Carlotta Masciocchi, Vincenzo Valentini, Andrés Cervantes
BACKGROUND: Adjuvant chemotherapy is controversial in patients with locally advanced rectal cancer after preoperative chemoradiation. Valentini et al developed 3 nomograms (VN) to predict outcomes in these patients. The neoadjuvant rectal score (NAR) was developed after VN to predict survival. We aimed to validate these tools in a retrospective cohort at an academic institution. PATIENTS AND METHODS: VN and the NAR were applied to 158 consecutive patients with locally advanced rectal cancer treated with chemoradiation followed by surgery...
October 28, 2017: Clinical Colorectal Cancer
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