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Performance validity testing

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https://www.readbyqxmd.com/read/28098776/distinguishing-benign-from-malignant-pancreatic-and-periampullary-lesions-using-combined-use-of-%C3%A2-h-nmr-spectroscopy-and-gas-chromatography-mass-spectrometry
#1
Yarrow J McConnell, Farshad Farshidfar, Aalim M Weljie, Karen A Kopciuk, Elijah Dixon, Chad G Ball, Francis R Sutherland, Hans J Vogel, Oliver F Bathe
Previous work demonstrated that serum metabolomics can distinguish pancreatic cancer from benign disease. However, in the clinic, non-pancreatic periampullary cancers are difficult to distinguish from pancreatic cancer. Therefore, to test the clinical utility of this technology, we determined whether any pancreatic and periampullary adenocarcinoma could be distinguished from benign masses and biliary strictures. Sera from 157 patients with malignant and benign pancreatic and periampullary lesions were analyzed using proton nuclear magnetic resonance (¹H-NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS)...
January 13, 2017: Metabolites
https://www.readbyqxmd.com/read/28098584/interrater-agreement-of-manual-palpation-for-identification-of-myofascial-trigger-points-a-systematic-review-and-meta-analysis
#2
Alasdair T L Rathbone, Liza Grosman-Rimon, Dinesh A Kumbhare
OBJECTIVE: To achieve a statistical estimate of the agreement of manual palpation for identification of myofascial trigger points (MTrPs) and secondarily to investigate potential factors impacting the agreement of this technique. METHODS: We searched MEDLINE(R) and Embase for studies examining the reproducibility of manual palpation for the identification of MTrPs from the year 2007 to present. In addition, we utilized studies identified by 2 comprehensive systematic reviews that covered the period before 2007...
January 17, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28098483/academic-performance-on-first-year-medical-school-exams-how-well-does-it-predict-later-performance-on-knowledge-based-and-clinical-assessments
#3
Edward Krupat, Stephen R Pelletier, Jules L Dienstag
Number of appearances in the bottom quartile of 1st-year medical school exams were used to represent the extent to which students were having academic difficulties. Medical educators have long expressed a desire to have indicators of medical student performance that have strong predictive validity. Predictors traditionally used fell into 4 general categories: demographic (e.g., gender), other background factors (e.g., college major), performance/aptitude (e.g., medical college admission test scores), and noncognitive factors (e...
January 18, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28098186/a-novel-multi-target-regression-framework-for-time-series-prediction-of-drug-efficacy
#4
Haiqing Li, Wei Zhang, Ying Chen, Yumeng Guo, Guo-Zheng Li, Xiaoxin Zhu
Excavating from small samples is a challenging pharmacokinetic problem, where statistical methods can be applied. Pharmacokinetic data is special due to the small samples of high dimensionality, which makes it difficult to adopt conventional methods to predict the efficacy of traditional Chinese medicine (TCM) prescription. The main purpose of our study is to obtain some knowledge of the correlation in TCM prescription. Here, a novel method named Multi-target Regression Framework to deal with the problem of efficacy prediction is proposed...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097669/mathematical-modeling-of-rotary-blood-pumps-in-a-pulsatile-in-vitro-flow-environment
#5
Tohid Pirbodaghi
Nowadays, sacrificing animals to develop medical devices and receive regulatory approval has become more common, which increases ethical concerns. Although in vivo tests are necessary for development and evaluation of new devices, nonetheless, with appropriate in vitro setups and mathematical models, a part of the validation process can be performed using these models to reduce the number of sacrificed animals. The main aim of this study is to present a mathematical model simulating the hydrodynamic function of a rotary blood pump (RBP) in a pulsatile in vitro flow environment...
January 18, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28097076/a-critical-issue-in-model-based-inference-for-studying-trait-based-community-assembly-and-a-solution
#6
Cajo J F Ter Braak, Pedro Peres-Neto, Stéphane Dray
Statistical testing of trait-environment association from data is a challenge as there is no common unit of observation: the trait is observed on species, the environment on sites and the mediating abundance on species-site combinations. A number of correlation-based methods, such as the community weighted trait means method (CWM), the fourth-corner correlation method and the multivariate method RLQ, have been proposed to estimate such trait-environment associations. In these methods, valid statistical testing proceeds by performing two separate resampling tests, one site-based and the other species-based and by assessing significance by the largest of the two p-values (the pmax test)...
2017: PeerJ
https://www.readbyqxmd.com/read/28096697/mir-486-3p-mir-139-5p-and-mir-21-as-biomarkers-for-the-detection-of-oral-tongue-squamous-cell-carcinoma
#7
Zujian Chen, Tianwei Yu, Robert J Cabay, Yi Jin, Ishrat Mahjabeen, Xianghong Luan, Lei Huang, Yang Dai, Xiaofeng Zhou
Oral tongue squamous cell carcinoma (TSCC) is a complex disease with extensive genetic and epigenetic defects, including microRNA deregulation. The aims of the present study were to test the feasibility of performing the microRNA profiling analysis on archived TSCC specimens and to assess the potential diagnostic utility of the identified microRNA biomarkers for the detection of TSCC. TaqMan array-based microRNA profiling analysis was performed on 10 archived TSCC samples and their matching normal tissues. A panel of 12 differentially expressed microRNAs was identified...
2017: Biomarkers in Cancer
https://www.readbyqxmd.com/read/28095905/imputing-hiv-treatment-start-dates-from-routine-laboratory-data-in-south-africa-a-validation-study
#8
Mhairi Maskew, Jacob Bor, Cheryl Hendrickson, William MacLeod, Till Bärnighausen, Deenan Pillay, Ian Sanne, Sergio Carmona, Wendy Stevens, Matthew P Fox
BACKGROUND: Poor clinical record keeping hinders health systems monitoring and patient care in many low resource settings. We develop and validate a novel method to impute dates of antiretroviral treatment (ART) initiation from routine laboratory data in South Africa's public sector HIV program. This method will enable monitoring of the national ART program using real-time laboratory data, avoiding the error potential of chart review. METHODS: We developed an algorithm to impute ART start dates based on the date of a patient's "ART workup", i...
January 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28095866/improvement-of-displacement-estimation-of-breast-tissue-in-ultrasound-elastography-using-the-monogenic-signal
#9
Taher Slimi, Ines Marzouk Moussa, Tarek Kraiem, Halima Mahjoubi
BACKGROUND: In breast ultrasound elastography, tissues displacements estimation is obtained through a technique that follows the evolution of tissues under stress. However, during the acquisition of B-mode images, tissue displacements are often contaminated with multiplicative noise caused by changes in the speckle pattern in the tissue. Thus, the application of monogenic signal technique on the B-mode image in order to estimate displacement tissue, result in a presence of amplified noise in the deformation tissue image, which severely obscures the useful information...
January 17, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28095857/real-time-inverse-kinematics-for-the-upper-limb-a-model-based-algorithm-using-segment-orientations
#10
Bence J Borbély, Péter Szolgay
BACKGROUND: Model based analysis of human upper limb movements has key importance in understanding the motor control processes of our nervous system. Various simulation software packages have been developed over the years to perform model based analysis. These packages provide computationally intensive-and therefore off-line-solutions to calculate the anatomical joint angles from motion captured raw measurement data (also referred as inverse kinematics). In addition, recent developments in inertial motion sensing technology show that it may replace large, immobile and expensive optical systems with small, mobile and cheaper solutions in cases when a laboratory-free measurement setup is needed...
January 17, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28095851/analytical-method-for-calculation-of-deviations-from-intended-dosages-during-multi-infusion
#11
Maurits K Konings, Roland A Snijder, Joris H Radermacher, Annemoon M Timmerman
BACKGROUND: In this paper, a new method is presented that combines mechanical compliance effects with Poiseuille flow and push-out effects ("dead volume") in one single mathematical framework for calculating dosing errors in multi-infusion set-ups. In contrast to existing numerical methods, our method produces explicit expressions that illustrate the mathematical dependencies of the dosing errors on hardware parameters and pump flow rate settings. METHODS: Our new approach uses the Z-transform to model the contents of the catheter, and after implementation in Mathematica (Wolfram), explicit expressions are produced automatically...
January 17, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28095706/translation-and-pilot-testing-of-a-measure-to-assess-hypertension-self-care-activities-among-hispanics
#12
Jan Warren-Findlow, Maren J Coffman, Celia A Karp
OBJECTIVE: Hispanics in the US have high rates of uncontrolled hypertension in comparison to non-Hispanic whites. This pilot study reports on the translation of a validated measure, the Hypertension Self-Care Activity Level Effects (H-SCALE), for use with Spanish speakers. The H-SCALE assesses Hispanics' adherence to lifestyle activities that contribute to primary and secondary risk reduction of high blood pressure. DESIGN: Cross-sectional data were collected from Hispanic primary care patients attending a free health clinic in Charlotte, NC...
January 17, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28095075/a-pilot-study-using-entropy-as-a-non-invasive-assessment-of-running
#13
Andrew M Murray, Joong Hyun Ryu, John Sproule, Anthony P Turner, Phil Graham-Smith, Marco Cardinale
PURPOSE: Running performance is influenced by the interaction of biomechanical and physiological factors. Miniaturised accelerometers worn by the athlete can be used to quantify mechanical aspects of running and be used as a non-invasive tool to assess training status and progression. The aim of this study was to define and validate a method to assess running regularity and allow the estimation of an individual's V̇O2 and/or blood lactate [La]b based on data collected with accelerometers and heart rate (HR)...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28095025/the-influence-of-personal-protection-equipment-occupant-body-size-and-restraint-system-on-the-frontal-impact-responses-of-hybrid-iii-atds-in-tactical-vehicles
#14
Lauren Wood Zaseck, Nichole Ritchie Orton, Rebekah Gruber, Jonathan Rupp, Risa Scherer, Matthew Reed, Jingwen Hu
OBJECTIVE: Although advanced restraint systems, such as seatbelt pretensioners, and load limiters, can provide improved occupant protection in crashes, such technologies are currently not utilized in military vehicles. The design and use of military vehicles presents unique challenges to occupant safety - including differences in compartment geometry and occupant clothing and gear - that make direct application of optimal civilian restraint systems to military vehicles inappropriate. For military vehicle environments, finite element (FE) modeling can be used to assess various configurations of restraint systems and determine the optimal configuration that minimizes injury risk to the occupant...
January 17, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28095001/callousness-and-affective-face-processing-in-adults-behavioral-and-brain-potential-indicators
#15
Sarah J Brislin, James R Yancey, Emily R Perkins, Isabella M Palumbo, Laura E Drislane, Randall T Salekin, Kostas A Fanti, Eva R Kimonis, Paul J Frick, R James R Blair, Christopher J Patrick
The investigation of callous-unemotional (CU) traits has been central to contemporary research on child behavior problems, and served as the impetus for inclusion of a specifier for conduct disorder in the latest edition of the official psychiatric diagnostic system. Here, we report results from 2 studies that evaluated the construct validity of callousness as assessed in adults, by testing for affiliated deficits in behavioral and neural processing of fearful faces, as have been shown in youthful samples. We hypothesized that scores on an established measure of callousness would predict reduced recognition accuracy and diminished electocortical reactivity for fearful faces in adult participants...
January 16, 2017: Personality Disorders
https://www.readbyqxmd.com/read/28094231/improving-efficiency-using-time-driven-activity-based-costing%C3%A2-methodology
#16
Laura C Tibor, Stacy R Schultz, Ronald Menaker, Bradley D Weber, Jay Ness, Paula Smith, Phillip M Young
PURPOSE: The aim of this study was to increase efficiency in MR enterography using a time-driven activity-based costing methodology. METHODS: In February 2015, a multidisciplinary team was formed to identify the personnel, equipment, space, and supply costs of providing outpatient MR enterography. The team mapped the current state, completed observations, performed timings, and calculated costs associated with each element of the process. The team used Pareto charts to understand the highest cost and most time-consuming activities, brainstormed opportunities, and assessed impact...
January 11, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28094038/triaging-hpv-positive-women-with-p16-ki-67-dual-stained-cytology-results-from-a-sub-study-nested-into-the-athena-trial
#17
Thomas C Wright, Catherine M Behrens, James Ranger-Moore, Susanne Rehm, Abha Sharma, Mark H Stoler, Ruediger Ridder
OBJECTIVES: In addition to genotyping for HPV16/18, dual-immunostaining for p16/Ki-67 has shown promise as a triage of HPV-positive women. We assessed the performance of p16/Ki-67 dual-stained cytology for triaging HPV-positive women undergoing primary HPV screening. METHODS: All women ≥25years with valid cervical biopsy and cobas® HPV Test results from the cross-sectional phase of ATHENA who were referred to colposcopy (n=7727) were eligible for enrolment. p16/Ki-67 dual-stained cytology was retrospectively performed on residual cytologic material collected into a second liquid-based cytology vial during the ATHENA enrolment visit...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28093868/applicability-of-the-chinese-version-of-the-personal-and-social-performance-scale-in-patients-with-severe-mental-disorders
#18
Ying Qiao, Shen He, Liang Su, Jian-Zheng Zhu, Jian-Hua Sheng, Hua-Fang Li
INTRODUCTION: This study was designed to determine the reliability and validity of the Chinese version of the Personal and Social Performance scale (PSP-CHN) and assess the applicability of using the PSP-CHN in patients with severe mental disorders. METHODS: A total of 285 outpatients with severe mental disorders, 220 with schizophrenia and 65 with major depressive disorder, were enrolled into the study. Both diagnoses were made using the DSM-IV. All the patients were assessed with the PSP-CHN, the GAF, and the CGI-S...
January 16, 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/28093788/north-american-population-based-validation-of-the-national-comprehensive-cancer-network-practice-guideline-recommendation-of-pelvic-lymphadenectomy-in-contemporary-prostate-cancer
#19
Sami-Ramzi Leyh-Bannurah, Lars Budäus, Raisa Pompe, Emanuele Zaffuto, Alberto Briganti, Firas Abdollah, Francesco Montorsi, Jonas Schiffmann, Mani Menon, Shahrokh F Shariat, Margit Fisch, Felix Chun, Hartwig Huland, Markus Graefen, Pierre I Karakiewicz
BACKGROUND: National Comprehensive Cancer Network (NCCN) guidelines recommend a pelvic lymph node dissection (PLND) in prostate cancer (PCa) patients treated with radical prostatectomy (RP) if a nomogram predicted risk of lymph node invasion (LNI) is ≥2%. We examined this and other thresholds, including nomogram validation. METHODS: We examined records of 26,713 patients treated with RP and PLND between 2010 and 2013, within the Surveillance, Epidemiology, and End Results database...
January 17, 2017: Prostate
https://www.readbyqxmd.com/read/28093766/psychometric-evaluation-of-the-sex-after-myocardial-infarction-knowledge-test-in-iranian-context
#20
Hossein Asgar Pour, Mohammad Reza Heidari, Reza Norouzzadeh, Fardin Rahimi, Anoshirvan Kazemnejad, Faramarz Fallahi
PURPOSE: To translate, adapt, and assess the psychometric properties of the Sex After MI Knowledge Test in Iranian context (where MI is myocardial infarction). DESIGN AND METHODS: A cross-sectional descriptive survey was performed. The sample comprised 250 patients with MI. Confirmatory factor analysis was applied to extract three indicators. FINDINGS: The Sex After MI Knowledge Test indicated good reproducibility (Cronbach's α = .76, Intraclass correlation (ICC) = 0...
January 16, 2017: Perspectives in Psychiatric Care
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