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JOURNAL ARTICLE
Sushant Sharma Chaudhary, Andrew Toivonen, Gaurav Waratkar, Geoffrey Mo, Deep Chatterjee, Sarah Antier, Patrick Brockill, Michael W Coughlin, Reed Essick, Shaon Ghosh, Soichiro Morisaki, Pratyusava Baral, Amanda Baylor, Naresh Adhikari, Patrick Brady, Gareth Cabourn Davies, Tito Dal Canton, Marco Cavaglia, Jolien Creighton, Sunil Choudhary, Yu-Kuang Chu, Patrick Clearwater, Luke Davis, Thomas Dent, Marco Drago, Becca Ewing, Patrick Godwin, Weichangfeng Guo, Chad Hanna, Rachael Huxford, Ian Harry, Erik Katsavounidis, Manoj Kovalam, Alvin K Y Li, Ryan Magee, Ethan Marx, Duncan Meacher, Cody Messick, Xan Morice-Atkinson, Alexander Pace, Roberto De Pietri, Brandon Piotrzkowski, Soumen Roy, Surabhi Sachdev, Leo P Singer, Divya Singh, Marek Szczepanczyk, Daniel Tang, Max Trevor, Leo Tsukada, Verónica Villa-Ortega, Linqing Wen, Daniel Wysocki
Multimessenger searches for binary neutron star (BNS) and neutron star-black hole (NSBH) mergers are currently one of the most exciting areas of astronomy. The search for joint electromagnetic and neutrino counterparts to gravitational wave (GW)s has resumed with ALIGO's, AdVirgo's and KAGRA's fourth observing run (O4). To support this effort, public semiautomated data products are sent in near real-time and include localization and source properties to guide complementary observations. In preparation for O4, we have conducted a study using a simulated population of compact binaries and a mock data challenge (MDC) in the form of a real-time replay to optimize and profile the software infrastructure and scientific deliverables...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
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JOURNAL ARTICLE
Tracie C Harrison, Shelley A Blozis, Janiece Taylor, Nandini Mukherjee, Lucia Caudillo Ortega, Nancy Blanco, Alexandra A Garcia, Sharon A Brown
BACKGROUND: Health disparities in osteoarthritis (OA) outcomes exist both in the occurrence and treatment of functional limitation and disability for Mexican Americans. Although the effect of self-management of chronic illness is well established, studies demonstrate little attention to self-management of function or disability, despite the strong potential effect on both and, consequently, on patients' lives. OBJECTIVE: The purpose of this study pilot was to develop and test key variable relationships for a measure of disability self-management among Mexican Americans...
May 2024: Nursing Research
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JOURNAL ARTICLE
Daniel L Hertz, Chad A Bousman, Howard L McLeod, Andrew A Monte, Deepak Voora, Lori A Orlando, Rustin D Crutchley, Benjamin Brown, Wrenda Teeple, Sara Rogers, Jai N Patel
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: Pharmacogenetic testing can identify patients who may benefit from personalized drug treatment...
April 23, 2024: American Journal of Health-system Pharmacy: AJHP
#4
JOURNAL ARTICLE
Akio Maki, Mamoru Narukawa
BACKGROUND: Early inclusion of Japan in the global development program could be a key factor in reducing the drug lag, making participation in phase I multiregional clinical trials (Ph. I MRCTs) an important consideration for oncology drug development in Japan. We aimed to investigate the factors associated with the inclusion of Japan in Ph. I MRCTs in oncology. METHODS: We compared the trial design, target population, type of primary tested drug, trial conduct profile, and sponsor profile for Ph...
April 23, 2024: Therapeutic Innovation & Regulatory Science
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JOURNAL ARTICLE
David H Miller, Carlie A LaLone, Daniel L Villeneuve, Gerald T Ankley
Accounting for intraspecific and interspecific competition when assessing the effects of chemical and nonchemical stressors is an important uncertainty in ecological risk assessments. We developed novel projection of interspecific competition (PIC) matrices that allow for analysis of population dynamics of two or more species exposed to a given stressor(s) that compete for shared resources within a landscape. We demonstrate the application of PIC matrices to investigate the population dynamics of two hypothetical fish species that compete with one another and have differences in net reproductive rate and intrinsic rate of population increase...
April 23, 2024: Environmental Toxicology and Chemistry
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JOURNAL ARTICLE
Charles H D Williamson, Adam J Vazquez, Amalee E Nunnally, Kristen Kyger, Viacheslav Y Fofanov, Tara N Furstenau, Heidie M Hornstra, Joel Terriquez, Paul Keim, Jason W Sahl
Escherichia coli is a diverse pathogen, causing a range of disease in humans, from self-limiting diarrhea to urinary tract infections (UTIs). Uropathogenic E. coli (UPEC) is the most frequently observed uropathogen in UTIs, a common disease in high-income countries, incurring billions of dollars yearly in treatment costs. Although E. coli is easily grown and identified in the clinical laboratory, genotyping the pathogen is more complicated, yet critical for reducing the incidence of disease. These goals can be achieved through whole-genome sequencing of E...
April 23, 2024: Microbiology Spectrum
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JOURNAL ARTICLE
Huijun Li, Megha Kalra, Lin Zhu, Deonna M Ackermann, Melody Taba, Carissa Bonner, Katy J L Bell
OBJECTIVE: To investigate the potential impacts of optimizing coronavirus disease 2019 (COVID-19) rapid antigen test (RAT) self-testing diagnostic accuracy information. DESIGN: Online randomized experiment using hypothetical scenarios: in scenarios 1 to 3 (RAT result positive), the posttest probability was considered to be very high (likely true positives), and in scenarios 4 and 5 (RAT result negative), the posttest probability was considered to be moderately high (likely false negatives)...
April 23, 2024: Medical Decision Making: An International Journal of the Society for Medical Decision Making
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JOURNAL ARTICLE
Clément Lanfranchi, Sarah J Willis, Louis Laramée, Sonia Conde Alonso, Vincent Pialoux, Bengt Kayser, Nicolas Place, Grégoire P Millet, Nadège Zanou
Athletes increasingly engage in repeated sprint training consisting in repeated short all-out efforts interspersed by short recoveries. When performed in hypoxia (RSH), it may lead to greater training effects than in normoxia (RSN); however, the underlying molecular mechanisms remain unclear. This study aimed at elucidating the effects of RSH on skeletal muscle metabolic adaptations as compared to RSN. Sixteen healthy young men performed nine repeated sprint training sessions in either normoxia (FI O2 = 0...
April 30, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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JOURNAL ARTICLE
Isaac Ignacio-Rodríguez, Roberto Barcala-Furelos, Ezequiel Rey, Marcos Sanmartín-Montes
Coastal environments present dynamic challenges necessitating rapid and efficient responses during aquatic emergencies. Lifeguards, as pivotal links in the intervention chain, rely on various tools, with rescue time being paramount. The choice of fins, specifically long versus short ones, plays a critical role in optimizing lifeguard performance during rescues. This randomized cross-over study explores the impact of flipper size on ocean rescues, employing a sample of 14 lifeguards. Long fins (LFs) and short fins (SFs) were compared in terms of rescue time (RT) and physiological load (PL)...
April 19, 2024: Journal of Functional Morphology and Kinesiology
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JOURNAL ARTICLE
Eleftherios Kellis, Athanasios Konstantopoulos, Georgios Salonikios, Athanasios Ellinoudis
The purpose of this study was to examine the effect of pelvic tilt angle on maximum hip and knee muscles' strength and antagonist/agonist strength ratios. Twenty-one young males and females performed maximum isokinetic concentric knee extension-flexion and hip extension-flexion efforts at 60°·s-1 , 120°·s-1 , and 180°·s-1 from three positions: anterior, neutral, and posterior pelvic tilt. Peak torques and knee flexor-to-extensor and hip flexor-to-extensor torque ratios were analyzed...
April 12, 2024: Journal of Functional Morphology and Kinesiology
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JOURNAL ARTICLE
Rajani S Sadasivam, Catherine S Nagawa, Jessica G Wijesundara, Julie Flahive, Hoa L Nguyen, Celine Larkin, Jamie M Faro, Kavitha Balakrishnan, Duc Anh Ha, Cuong Kieu Nguyen, Anh Vuong, Phuong Thu Phan, Quyen Phi Li Pham, Jeroan J Allison, Thomas Karr Houston
Objectives: We tested an adapted version of an effective U.S.-based peer-texting intervention to promote Quitline use and smoking cessation among rural participants in Vietnam. Methods: We conducted a two-arm randomized trial with participants recruited at four rural community centers. The intervention included peer messages sent for six months that promoted Quitline use and smoking cessation. Additionally, biweekly two-way text messages assessed participants' interest in Quitline referral and current smoking status...
2024: International Journal of Public Health
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JOURNAL ARTICLE
Rodney Ogwang, Lewis Murugu, Irene N Nkumama, Lydia Nyamako, Oscar Kai, Kennedy Mwai, Linda Murungi, Richard Idro, Philip Bejon, James Tuju, Sam Muchina Kinyanjui, Faith H A Osier
BACKGROUND: Malaria remains a major global health priority, and monoclonal antibodies (mAbs) are emerging as potential new tools to support efforts to control the disease. Recent data suggest that Fc-dependent mechanisms of immunity are important mediators of protection against the blood stages of the infection, but few studies have investigated this in the context of mAbs. We aimed to isolate mAbs agnostic to cognate antigens that target whole merozoites and simultaneously induce potent neutrophil activity measured by the level of reactive oxygen species (ROS) production using an antibody-dependent respiratory burst (ADRB) assay...
2024: Frontiers in Immunology
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JOURNAL ARTICLE
Manan M Nayak, Emanuele Mazzola, Michael T Jaklitsch, Jeremy E Drehmer, Emara Nabi-Burza, Raphael Bueno, Jonathan P Winickoff, Mary E Cooley
INTRODUCTION: Effective tobacco treatments are available but are often not delivered to individuals with an actual or potential diagnosis of thoracic malignancy. The specific aims of this study were to identify the prevalence of tobacco use and examine the effectiveness of the Clinical and community Effort Against Smoking and secondhand smoke Exposure (CEASE), a system-level computer-facilitated intervention, to improve provider delivery of tobacco treatment in a thoracic surgery and oncology outpatient setting...
2024: Tobacco Induced Diseases
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JOURNAL ARTICLE
Kirsten M A Trayner, Alan Yeung, Norah E Palmateer, Andrew McAuley, Max Wilkinson, Julie Craik, Rebecca Metcalfe, Erica Peters, Samantha J Shepherd, Rory N Gunson, Daniel Carter, Laura Sills, Sharon J Hutchinson
Glasgow, Scotland's largest city, has been experiencing an HIV outbreak among people who inject drugs (PWID) since 2015. A key focus of the public health response has been to increase HIV testing among those at risk of infection. Our aim was to assess the impact of COVID-19 on HIV testing among PWID in Glasgow. HIV test uptake in the last 12 months was quantified among: (1) PWID recruited in six Needle Exchange Surveillance Initiative (NESI) surveys (n = 6110); linked laboratory data for (2) people prescribed opioid agonist therapy (OAT) (n = 14,527) and (3) people hospitalised for an injecting-related hospital admission (IRHA) (n = 12,621) across four time periods: pre-outbreak (2010-2014); early-outbreak (2015-2016); ongoing-outbreak (2017-2019); and COVID-19 (2020-June 21)...
April 22, 2024: AIDS and Behavior
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JOURNAL ARTICLE
Peggy J Lelesi, Leciel Bono, JoAnn R Gurenlian
Purpose The relative newness of Post-COVID Conditions (PCC) has revealed a void in assessment protocols and treatment guidelines for dental settings. Providing oral health care practitioners with an assessment and treatment protocol could facilitate the delivery of comprehensive oral health care. The purpose of this study was to test a protocol for assessing and treating patients with PCC in dental practice settings. Methods A qualitative exploratory research design was used to conduct the study. A PCC assessment and treatment protocol (ATP) was developed and was used by dental hygienists in clinical practice in California for a period of 6 weeks...
April 2024: Journal of Dental Hygiene: JDH
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JOURNAL ARTICLE
Erin Ussery, Mark McMaster, Vince Palace, Joanne Parrott, Nicholas C Blandford, Richard Frank, Karen Kidd, Oana Birceanu, Joanna Wilson, Mehran Alaee, Jessie Cunningham, Abby Wynia, Thomas Clark, Sheena Campbell, Lauren Timlick, Sonya Michaleski, Stephanie Marshall, Kristin Nielsen
Due to its widespread use for the treatment of Type-2 diabetes, metformin is routinely detected in surface waters globally. Laboratory studies have shown that environmentally relevant concentrations of metformin can adversely affect the health of adult fish, with effects observed more frequently in males. However, the potential risk to wild fish populations has yet to be fully elucidated and remains a topic of debate. To explore whether environmentally relevant metformin exposure poses a risk to wild fish populations, the present study exposed wild fathead minnows (Pimephales promelas) to 5 or 50 μg/L metformin via 2 m diameter in-lake mesocosms deployed in a natural boreal lake in Northern Ontario at the International Institute for Sustainable Development - Experimental Lakes Area (IISD-ELA)...
April 20, 2024: Science of the Total Environment
#17
JOURNAL ARTICLE
Chortip Sajjaviriya, Fujianti, Morio Azuma, Hiroyoshi Tsuchiya, Taka-Aki Koshimizu
Close contact between lactating rodent mothers and their infants is essential for effective nursing. Whether the mother's effort to retrieve the infants to their nest requires the vasopressin-signaling via V1b receptor has not been fully defined. To address this question, V1b receptor knockout (V1bKO) and control mice were analyzed in pup retrieval test. Because an exploring mother in a new test cage randomly accessed to multiple infants in changing backgrounds over time, a computer vision-based deep learning analysis was applied to continuously calculate the distances between the mother and the infants as a parameter of their relationship...
April 20, 2024: Peptides
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JOURNAL ARTICLE
Nirmal Choradia, Aaron Mitchell, Ryan Nipp
BACKGROUND: The health care industry spends more on lobbying than any other industry, with more than $700 million spent in 2022. However, health care lobbying related to cancer has not been characterized. In this study, we sought to describe overall health sector lobbying spending and oncology-related lobbying spending across patient and clinician organizations. METHODS: We obtained lobbying data from OpenSecrets.org and the Federal Election Commission. Overall health sector lobbying spending was categorized by OpenSecrets into 4 groups: pharmaceuticals/health products, health services/health maintenance organizations (HMOs), hospitals/nursing homes, and health professionals...
April 19, 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#19
JOURNAL ARTICLE
Robert E Black, Jamie Perin, Diana Yeung, Tushara Rajeev, Jacob Miller, Sarah E Elwood, James A Platts-Mills
BACKGROUND: Information on the causes of deaths from diarrhoea in children younger than 5 years is needed to design improved preventive and therapeutic approaches. We aimed to conduct a systematic analysis of studies to report estimates of the causes of deaths from diarrhoea in children younger than 5 years at global and regional levels during 2000-21. METHODS: For this systematic review and Bayesian multinomial analysis, we included 12 pathogens with the highest attributable incidence in the Global Enteric Multicenter Study...
April 19, 2024: Lancet Global Health
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JOURNAL ARTICLE
Misuzu Fujita, Kengo Nagashima, Minobu Shimazu, Misae Suzuki, Ichiro Tauchi, Miwa Sakuma, Setsuko Yamamoto, Hideki Hanaoka, Makio Shozu, Nobuhide Tsuruoka, Tokuzo Kasai, Akira Hata
Japan is lagging in cervical cancer prevention. The effectiveness of a self-sampling human papillomavirus (HPV) test, a possible measure to overcome this situation, has not yet been evaluated. A randomized controlled trial was performed to evaluate the effectiveness of a self-sampling HPV test on detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and screening uptake. Women between 30 and 58 years old who did not participate in the cervical cancer screening program for ≥3 years were eligible and assigned to the intervention group (cytology or self-sampling HPV test) or control group (cytology)...
April 22, 2024: International Journal of Cancer. Journal International du Cancer
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