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cancer related cognitive impairment

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https://www.readbyqxmd.com/read/29663137/health-related-quality-of-life-among-cancer-patients-in-their-last-year-of-life-results-from-the-profiles-registry
#1
Natasja J H Raijmakers, M Zijlstra, J van Roij, O Husson, S Oerlemans, L V van de Poll-Franse
PURPOSE: The aim of this study was to assess health-related quality of life (HRQoL) in the last year of life of cancer patients stratified by four periods of time before death. PATIENTS AND METHODS: Between 2008 and 2015, cancer patients were invited to participate in PROFILES (Patient Reported Outcomes Following Initial Treatment and Long-term Evaluation of Survivorship) registry studies. Patients were eligible for inclusion in this secondary analysis if they had been invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) in their last year of life (N = 892)...
April 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29617869/changes-in-brain-structural-networks-and-cognitive-functions-in-testicular-cancer-patients-receiving-cisplatin-based-chemotherapy
#2
Ali Amidi, S M Hadi Hosseini, Alexander Leemans, Shelli R Kesler, Mads Agerbæk, Lisa M Wu, Robert Zachariae
Background: Cisplatin-based chemotherapy may have neurotoxic effects within the central nervous system. The aims of this study were 1) to longitudinally investigate the impact of cisplatin-based chemotherapy on whole-brain networks in testicular cancer patients undergoing treatment and 2) to explore whether possible changes are related to decline in cognitive functioning. Methods: Sixty-four newly orchiectomized TC patients underwent structural magnetic resonance imaging (T1-weighted and diffusion-weighted imaging) and cognitive testing at baseline prior to further treatment and again at a six-month follow-up...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29578249/preoperative-vitamin-d-deficiency-increases-the-risk-of-postoperative-cognitive-dysfunction-a-predefined-exploratory-sub-analysis
#3
Y Zhang, G-J Shan, Y-X Zhang, S-J Cao, S-N Zhu, H-J Li, D Ma, D-X Wang
BACKGROUND: Vitamin D is important for maintaining physiological functions including cognition and its deficiency is associated with the occurrence of cognitive impairment. This study was to explore the association between preoperative vitamin D status and the occurrence of postoperative cognitive dysfunction (POCD) in elderly patients undergoing major surgery. METHODS: This was a predefined exploratory sub-analysis of one-centre data from a randomized controlled trial...
March 26, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29573086/electrochemical-measurement-of-dopamine-release-and-uptake-in-zebrafish-following-treatment-with-carboplatin
#4
Michael A Johnson, Thomas Field, Mimi Shin, Chase Stucky, Joseph Loomis
Post chemotherapy cognitive impairment, also known as 'chemobrain,' is a neurological condition in which cognitive function is impaired as a result of cancer chemotherapy treatment. In this work, we used fast-scan cyclic voltammetry (FSCV) to measure electrically evoked dopamine release and uptake in whole brain preparations from zebrafish that have been treated with carboplatin, an agent associated with chemobrain. We administered carboplatin by addition to the fish's tank water or their food. One week of treatment with 100 µM carboplatin in the water was needed to significantly impair dopamine release (~40% of control); however, only one day of treatment through the zebrafish's food was needed to cause a similar impairment...
March 23, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29514170/association-of-fatigue-intensification-with-cognitive-impairment-during-radiation-therapy-for-prostate-cancer
#5
Li Rebekah Feng, Alexandra Espina, Leorey N Saligan
PURPOSE: Cancer-related fatigue is a common complaint during cancer treatment and is often associated with cognitive impairment. This study examined cognitive deficits that were associated with fatigue symptoms during external-beam radiation therapy (EBRT) in men with localized prostate cancer. METHODS: A total of 36 participants were enrolled and followed up at baseline, 24 h, 7 days, 14 days after EBRT initiation, at midpoint, and at completion of EBRT. Fatigue was measured by self-report using the Functional Assessment of Cancer Therapy - Fatigue (FACT-F), and cognitive impairment by the Computer Assessment of Mild Cognitive Impairment (CAMCI®)...
March 7, 2018: Oncology
https://www.readbyqxmd.com/read/29512061/living-with-merkel-cell-carcinoma-mcc-development-of-a-conceptual-model-of-mcc-based-on-patient-experiences
#6
Howard L Kaufman, Carla Dias Barbosa, Isabelle Guillemin, Jérémy Lambert, Lisa Mahnke, Murtuza Bharmal
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with limited treatment options at advanced stages. There is a paucity of data available regarding the impact of MCC and its management on patients' lives. This study aimed to address this gap by interviewing patients with metastatic MCC entering a trial of an immunotherapy (avelumab). METHODS: In a single-arm, open-label, international, phase 2 trial in patients with stage IV, chemotherapy-refractory, histologically confirmed MCC, patients were invited to participate in semi-structured phone interviews...
March 6, 2018: Patient
https://www.readbyqxmd.com/read/29506297/-exercise-and-physical-activity-during-and-after-cancer-who-benefits-most-what-is-proven
#7
Karen Steindorf, Martina E Schmidt, Philipp Zimmer
A growing number of literature reports positive effects of physical activity and exercise. These effects concern prevention, mortality and progress of cancer. Furthermore they show a reduction of disease- and treatment-specific side effects, which implies a better patients' quality of life. Evidence shows a decreased mortality risk in patients with physically active cancer of colon, breast, ovaries and prostate. Activity recommendations for patients with cancer do not differ from those for healthy persons...
March 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29503217/estimating-the-frequency-severity-and-clustering-of-spade-symptoms-in-chronic-painful-chemotherapy-induced-peripheral-neuropathy
#8
Robert Knoerl, Zach Chornoby, Ellen M L Smith
Patients undergoing treatment for cancer commonly experience symptoms such as sleep disturbance, pain, anxiety, depression, and low energy/fatigue (SPADE), subsequently altering physical function and complicating effective symptom management. However, little is known about the frequency, severity, and clustering of SPADE symptoms in individuals with chronic painful chemotherapy-induced peripheral neuropathy (CIPN). The purpose of this cross-sectional, secondary analysis was to describe the frequency, severity, and clustering of SPADE symptoms and their association with physical function in individuals with chronic painful CIPN...
March 1, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29501739/protocol-for-exercise-program-in-cancer-and-cognition-epicc-a-randomized-controlled-trial-of-the-effects-of-aerobic-exercise-on-cognitive-function-in-postmenopausal-women-with-breast-cancer-receiving-aromatase-inhibitor-therapy
#9
Amanda L Gentry, Kirk I Erickson, Susan M Sereika, Frances E Casillo, Mary E Crisafio, Patrick T Donahue, George A Grove, Anna L Marsland, Jennifer C Watt, Catherine M Bender
The Exercise Program in Cancer and Cognition (EPICC) Study is a randomized controlled trial designed to test the effects of moderate-intensity aerobic exercise on cognitive function in postmenopausal women with early-stage breast cancer during the first six months of aromatase inhibitor therapy. It is estimated that up to 75% of survivors of breast cancer experience cognitive impairment related to disease and treatment. At present, there are no known interventions to improve or manage cognitive function for women with breast cancer...
April 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29497579/cognitive-impairment-associated-with-cancer-a-brief-review
#10
REVIEW
J Cara Pendergrass, Steven D Targum, John E Harrison
This brief review explores the areas of cognitive impairment that have been observed in cancer patients and survivors, the cognitive assessment tools used, and the management of the observed cognitive changes. Cognitive changes and impairment observed in patients with cancer and those in remission can be related to the direct effects of cancer itself, nonspecific factors or comorbid conditions that are independent of the actual disease, and/or the treatments or combination of treatments administered. Attention, memory, and executive functioning are the most frequently identified cognitive domains impacted by cancer...
February 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29485298/the-danish-version-of-lymphoedema-functioning-disability-and-health-questionnaire-lymph-icf-for-breast-cancer-survivors-translation-and-cultural-adaptation-followed-by-validity-and-reliability-testing
#11
Karin R Grarup, Nele Devoogdt, Liv Inger Strand
PURPOSE: To translate and culturally adapt the Lymphoedema Functioning, Disability and Health Questionnaire (Lymph-ICF) for breast cancer survivors with arm lymphedema into Danish and examine its content validity and reliability. METHODS: (1) Translation and cultural adaptation was performed in 10 steps following international guidelines (International Society for Pharmacoeconomics and Outcome Research); (2) cognitive interviewing (step 7) was conducted in 15 women with breast cancer related arm lymphedema to explore understandability, interpretation, and cultural relevance; (3) after adjustments, content validity (N = 52) was explored by interviews; and (4) reliability (N = 50) examined by intraclass correlation coefficients (ICC) statistics and Cronbach alpha analysis...
February 27, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29477301/physical-exercise-prevents-cognitive-impairment-by-enhancing-hippocampal-neuroplasticity-and-mitochondrial-function-in-doxorubicin-induced-chemobrain
#12
Hye-Sang Park, Chang-Ju Kim, Hyo-Bum Kwak, Mi-Hyun No, Jun-Won Heo, Tae-Woon Kim
Although chemotherapy increases the survival rate of patients with various cancers, such treatment can induce acute or long-term cognitive dysfunction a phenomenon known as post-chemotherapy cognitive impairment (PCCI) or "chemobrain." Exercise is known to positively affect brain function. Thus, the present study aimed to determine whether symptoms of chemobrain and disruptions in the neuroplasticity and functioning of hippocampal mitochondria can be prevented or relieved by exercise. Wistar rats were separated into the following groups: control, control plus exercise, chemobrain, and chemobrain plus exercise...
February 22, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29477224/dietary-vitamin-c-in-human-health
#13
Matthew Granger, Peter Eck
Vitamin C is essential to prevent scurvy in humans and is implicated in the primary prevention of common and complex diseases such as coronary heart disease, stroke, and cancer. This chapter reviews the latest knowledge about dietary vitamin C in human health with an emphasis on studies of the molecular mechanisms of vitamin C maintenance as well as gene-nutrient interactions modifying these relationships. Epidemiological evidence indicates 5% prevalence for vitamin C deficiency and 13% prevalence for suboptimal status even in industrialized countries...
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29471454/the-impact-of-using-different-reference-populations-on-measurement-of-breast-cancer-related-cognitive-impairment-rates
#14
Jonathan D Clapp, George Luta, Brent J Small, Tim A Ahles, James C Root, Deena Graham, Arti Hurria, Paul B Jacobsen, Heather Jim, Brenna C McDonald, Robert A Stern, Andrew J Saykin, Jeanne S Mandelblatt
Objective: To evaluate how use of different reference populations affects estimates of breast cancer-related cognitive impairment rates. Methods: Patients aged ≥60 years with stage 0-3 breast cancer (n = 371) and matched non-cancer controls (n = 370) completed 13 neuropsychological tests prior to systemic therapy or at enrollment (controls). The tests captured three domains: attention, processing speed and executive function; learning and memory; and visual-spatial function...
February 17, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29468740/neuroprotective-effects-of-20-s-protopanaxatriol-ppt-on-scopolamine-induced-cognitive-deficits-in-mice
#15
Cong Lu, Jingwei Lv, Liming Dong, Ning Jiang, Yan Wang, Qiong Wang, Yinghui Li, Shanguang Chen, Bei Fan, Fengzhong Wang, Xinmin Liu
20(S)-protopanaxatriol (PPT), one of the ginsenosides from Panax ginseng, has been reported to have neuroprotective effects and to improve memory. The present study was designed to investigate the protective effect of PPT on scopolamine-induced cognitive deficits in mice. Male Institute of Cancer Research mice were pretreated with 2 different doses of PPT (20 and 40 μmol/kg) for 27 days by intraperitoneal injection, and scopolamine (0.75 mg/kg) was injected intraperitoneally for 9 days to induce memory impairment...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29468085/feasibility-of-a-combined-aerobic-and-cognitive-training-intervention-on-cognitive-function-in-cancer-survivors-a-pilot-investigation
#16
Brent M Peterson, Cynthia Johnson, Kaylene R Case, Daniel Y K Shackelford, Jessica M Brown, Trent L Lalonde, Reid Hayward
Background: Cancer-related cognitive impairment (CRCI) may negatively affect upwards of 75% of cancer patients. Exercise and cognitive training, independently, may increase functional capacity and aspects of cognitive function. Yet, combined training protocols have not been evaluated in cancer survivor populations. Therefore, the aim of this study was to explore the feasibility of a quasi-randomized, controlled, exploratory, repeated-measures aerobic and cognitive training intervention on cognitive function in participants undergoing treatment for cancer ( N  = 28)...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29461649/contextual-and-stress-process-factors-associated-with-head-and-neck-cancer-caregivers-physical-and-psychological-well-being
#17
M-S Paek, C L Nightingale, J A Tooze, B-J Milliron, K E Weaver, K R Sterba
Head and neck cancer (HNC) caregivers are especially vulnerable to poor outcomes because the HNC patients are at high risk for physical and functional impairments. This study examines contextual and stress process variables potentially associated with HNC caregivers' physical and psychological well-being. Patient-caregiver variables included socio-demographics, primary stressors (caregiving, patient clinical characteristics, HNC-related symptoms/dysfunction), secondary stressors (caregiver employment, childcare responsibilities and sleep duration <7 hr), appraisal, and response (physical activity)...
February 20, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29453297/what-factors-mediate-the-inter-relationship-between-frailty-and-pain-in-cognitively-and-functionally-sound-older-adults-a-prospective-longitudinal-ageing-cohort-study-in-taiwan
#18
Jing-Hui Chiou, Li-Kuo Liu, Wei-Ju Lee, Li-Ning Peng, Liang-Kung Chen
OBJECTIVES: The main aim was to investigate the complex inter-relationship between frailty and pain, and the mediating roles of cognitive function, morbidity and mood in this nexus. DESIGN: A cross-sectional analysis. SETTING: A prospective community-dwelling population-based cohort. PARTICIPANTS: 1682 adults age ≥50 years without evident cognitive or functional impairment, or history of cancer. PRIMARY AND SECONDARY OUTCOME MEASURES: The mediating effect of depression, cognitive function and comorbidity on the nexus between pain and frailty among older and middle-aged adults...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438648/managing-menopausal-symptoms-after-cancer-an-evidence-based-approach-for-primary-care
#19
Jennifer L Marino, Helen C McNamara, Martha Hickey
Impaired ovarian function and menopausal symptoms are common after cancer treatment. Menopausal symptoms often occur at an earlier age in women with cancer, and may be more severe than in natural menopause; they may be the most persistent and troubling sequelae of cancer. A third of female patients with cancer report dissatisfaction with the quality and length of physician-patient discussions about reproductive health, including menopause. Systemic menopausal hormone therapy is the most effective treatment for menopausal symptoms, but it is not suitable for all patients after cancer - where it is unsuitable, alternative effective non-hormonal treatments are available...
February 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29424302/the-role-of-5-ht1a-receptor-in-the-cancer-as-a-new-opportunity-in-medicinal-chemistry
#20
Angela Corvino, Ferdinando Fiorino, Beatrice Severino, Irene Saccone, Francesco Frecentese, Elisa Perissutti, Paola Di Vaio, Vincenzo Santagada, Giuseppe Caliendo, Elisa Magli
The 5-HT1A receptor is a pharmacologically well characterized serotonin receptor subtype and it has long been investigated because of its involvement in several physio-pathological mechanisms and treatment of neurological diseases like ansia and depression. Serotonin (5-HT) also shows many non-neural functions such as essential hypertension, embryogenesis, follicle maturation and behavior. Moreover it exerts a growth factor function on different types of non-tumoral cells, and it was also found to be related to oncogenes...
February 9, 2018: Current Medicinal Chemistry
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