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cancer related cognitive impairment

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https://www.readbyqxmd.com/read/29187817/predicting-long-term-cognitive-outcome-following-breast-cancer-with-pre-treatment-resting-state-fmri-and-random-forest-machine-learning
#1
Shelli R Kesler, Arvind Rao, Douglas W Blayney, Ingrid A Oakley-Girvan, Meghan Karuturi, Oxana Palesh
We aimed to determine if resting state functional magnetic resonance imaging (fMRI) acquired at pre-treatment baseline could accurately predict breast cancer-related cognitive impairment at long-term follow-up. We evaluated 31 patients with breast cancer (age 34-65) prior to any treatment, post-chemotherapy and 1 year later. Cognitive testing scores were normalized based on data obtained from 43 healthy female controls and then used to categorize patients as impaired or not based on longitudinal changes. We measured clustering coefficient, a measure of local connectivity, by applying graph theory to baseline resting state fMRI and entered these metrics along with relevant patient-related and medical variables into random forest classification...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29186986/steroid-induced-mental-disorders-in-cancer-patients-a-systematic-review
#2
Muhammad Fahmi Ismail, Clianna Lavelle, Eugene M Cassidy
Corticosteroids are a central part of many cancer treatment regimens. Neuropsychiatric toxicity has complicated their use, including an association with a spectrum of symptoms, from insomnia, cognitive impairment and mood symptoms, to severe mental disorders, including mania, psychosis and severe depression. Although steroid-induced mental disorders were first reported in medicine more than 60 years ago, there is a dearth of evidence available to date on optimal treatment and prevention to guide cancer clinicians...
November 30, 2017: Future Oncology
https://www.readbyqxmd.com/read/29179739/subjective-cognitive-impairment-and-brain-structural-networks-in-chinese-gynaecological-cancer-survivors-compared-with-age-matched-controls-a-cross-sectional-study
#3
Yingchun Zeng, Andy S K Cheng, Ting Song, Xiujie Sheng, Yang Zhang, Xiangyu Liu, Chetwyn C H Chan
BACKGROUND: Subjective cognitive impairment can be a significant and prevalent problem for gynaecological cancer survivors. The aims of this study were to assess subjective cognitive functioning in gynaecological cancer survivors after primary cancer treatment, and to investigate the impact of cancer treatment on brain structural networks and its association with subjective cognitive impairment. METHODS: This was a cross-sectional survey using a self-reported questionnaire by the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) to assess subjective cognitive functioning, and applying DTI (diffusion tensor imaging) and graph theoretical analyses to investigate brain structural networks after primary cancer treatment...
November 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29168289/cannabinoids-for-nausea-and-vomiting-related-to-chemotherapy-overview-of-systematic-reviews
#4
REVIEW
Victor Schussel, Lucas Kenzo, Andreia Santos, Júlia Bueno, Ellen Yoshimura, Carolina de Oliveira Cruz Latorraca, Daniela Vianna Pachito, Rachel Riera
Nausea and vomiting are common and distressing adverse events of chemotherapy. This review focuses on the findings and quality of systematic reviews (SRs) of cannabinoids for chemotherapy-induced nausea and vomiting (CINV). Review of SRs, a systematic literature search, was conducted in several electronic databases and included SRs evaluating cannabinoids for CINV in cancer patients. Methodological quality and quality of reporting were evaluated by AMSTAR and PRISMA, respectively. Initial search retrieved 2,206 records, and 5 SRs were included...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29128118/associations-between-inflammatory-markers-and-cognitive-function-in-breast-cancer-patients-receiving-chemotherapy
#5
AnnaLynn M Williams, Raven Shah, Michelle Shayne, Alissa J Huston, Marcia Krebs, Nicole Murray, Bryan D Thompson, Kassandra Doyle, Jenna Korotkin, Edwin van Wijngaarden, Sharon Hyland, Jan A Moynihan, Deborah A Cory-Slechta, Michelle C Janelsins
BACKGROUND: Cancer-related cognitive impairment (CRCI) is often related to chemotherapy. Increased chronic inflammation is believed to play a key role in the development of CRCI related to chemotherapy but studies assessing this hypothesis specifically in patients receiving chemotherapy are rare. METHODS: We assessed several cognitive domains using the Cambridge Neuropsychological Test Automated Battery (CANTAB) in twenty-two breast cancer patients currently receiving chemotherapy...
October 18, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29127529/the-impact-of-prostate-cancer-diagnosis-and-treatment-decision-making-on-health-related-quality-of-life-before-treatment-onset
#6
Maarten Cuypers, Romy E D Lamers, Erik B Cornel, Lonneke V van de Poll-Franse, Marieke de Vries, Paul J M Kil
OBJECTIVE: The objective of this study is to test if patients' health-related quality of life (HRQoL) declines after prostate biopsy to detect Pca, and after subsequent treatment decision-making in case Pca is confirmed, and to test whether personality state and traits are associated with these potential changes in HRQoL. METHODS: Patients who were scheduled for prostate biopsy to detect Pca (N = 377) filled out a baseline questionnaire about HRQoL (EORTC QLQ-C30 and PR25), "big five" personality traits (BFI-10), optimism (LOT-r), and self-efficacy (Decision Self-efficacy Scale) (t0)...
November 10, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29121713/health-related-quality-of-life-in-non-hodgkin-lymphoma-survivors-a-prospective-cohort-study
#7
Danbee Kang, Juhee Cho, ImRyung Kim, Mi Kyung Kim, Won Seog Kim, Seok Jin Kim
Purpose: We evaluated health-related quality of life (HRQOL) in long-term survivors of indolent and aggressive non-Hodgkin lymphoma (NHL). Materials and methods: The HRQOL was assessed by the European Organization for Research and Treatment of Cancer Quality-of-Life questionnaire Core 30 (EORTC QLQ-C30) at diagnosis in NHL patients between 2008 and 2011, and follow-up evaluation was conducted from June 2014 to Feb 2015 using EORTC QLQ-C30 and the quality of life in cancer survivors (QOL-CS) questionnaire...
November 9, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29113931/neurobiological-mechanisms-of-chemotherapy-induced-cognitive-impairment-in-a-transgenic-model-of-breast-cancer
#8
Gordon Winocur, Hal Berman, Mary Nguyen, Malcolm A Binns, Mark Henkelman, Matthijs van Eede, Micheline Piquette-Miller, Melanie J Sekeres, J Martin Wojtowicz, Johnson Yu, Haibo Zhang, Ian F Tannock
Animal studies have reinforced clinical reports of cognitive impairment in cancer survivors following chemotherapy but, until now, all pre-clinical research in this area has been conducted on normal rodents. The present study investigated the effects of chemotherapy on cognition and underlying biological mechanisms in the FVB/N-Tg (MMTV-neu) 202 Mul/J mouse, a well-characterized transgenic model of breast cancer that has similarities to the tumorigenesis which occurs in humans. Tumor-bearing and control mice received three weekly injections of a combination of methotrexate + 5-fluorouracil, or an equal volume of saline...
November 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/29106018/quality-of-life-assessment-in-patients-with-nonmelanoma-skin-cancer-psychometric-validation-of-the-eortc-qlq-c30-questionnaire
#9
Karolina Müller, Sigrid Karrer, Rolf-Markus Szeimies, Julia Steinbauer, Elisabeth Kohl, Dominik Steinbauer, Florian Zeman, Mark Berneburg, Michael Koller
BACKGROUND: Nonmelanoma skin cancer (NMSC) is a chronic and sometimes difficult-to-treat condition affecting the quality of life (QL). The present study was conducted to investigate whether the European Organization for Research and Treatment of Cancer (EORTC) core QL Questionnaire - Cancer (QLQ-C30) is a suitable tool for the assessment of QL in patients with NMSC. PATIENTS AND METHODS: In order to define the psychometric properties of the questionnaire, the QLQ-C30 and the Dermatology Life Quality Index (DLQI) were handed out to 172 patients of the Department of Dermatology at the University Hospital Regensburg, Germany...
November 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29092778/cognitive-impairment-in-breast-cancer-survivors-treated-with-chemotherapy-depends-on-control-group-type-and-cognitive-domains-assessed-a-multilevel-meta-analysis
#10
REVIEW
Lori J Bernstein, Graham A McCreath, Zahra Komeylian, Jill B Rich
Women with breast cancer can experience persisting cognitive deficits post treatment. We conducted a multilevel meta-analysis of cognitive function in survivors treated with chemotherapy (Ch+) to estimate the magnitude of cognitive impairment relative to healthy (HC) and chemo-negative (Ch-) controls. Seventy-two studies published up to October 2016 involving 2939 Ch+ yielded 1594 effect sizes. Ch+ demonstrated overall cognitive impairment in comparison with HC but not with Ch-. Relative to HC, Ch+ showed impairment in attention/concentration, processing speed, language, immediate recall, delayed recall, and executive function...
October 29, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29090187/multimorbidity-constellations-of-conditions-across-subgroups-of-midlife-and-older-individuals-and-related-medicare-expenditures
#11
Siran M Koroukian, Nicholas K Schiltz, David F Warner, Jiayang Sun, Kurt C Stange, Charles W Given, Avi Dor
INTRODUCTION: The Department of Health and Human Services' 2010 Strategic Framework on Multiple Chronic Conditions called for the identification of common constellations of conditions in older adults. OBJECTIVES: To analyze patterns of conditions constituting multimorbidity (CCMM) and expenditures in a US representative sample of midlife and older adults (50-64 and ≥65 years of age, respectively). DESIGN: A cross-sectional study of the 2010 Health and Retirement Study (HRS; n=17,912)...
2017: Journal of comorbidity
https://www.readbyqxmd.com/read/29082800/carer-experience-supporting-someone-with-dementia-and-cancer-a-narrative-approach
#12
Gary Witham, Carol Haigh, Duncan Mitchell, Anna Beddow
In this article, we examine the challenges of informal carers supporting someone with dementia and cancer within the United Kingdom. Interviews were conducted with seven informal carers using a narrative approach to examine the construction of their experiences. Our findings demonstrate how informal carers navigate a path through complex cancer treatments and support their relative. A cancer diagnosis often requires multiple treatment visits to an oncology center, and this can be challenging for carers. They find that they need to coordinate and manage both health professionals and their relative in terms of getting access to appropriate services and support...
October 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/29080061/perceived-cognitive-impairment-in-people-with-colorectal-cancer-who-do-and-do-not-receive-chemotherapy
#13
Haryana M Dhillon, Ian F Tannock, Gregory R Pond, Corrinne Renton, Sean B Rourke, Janette L Vardy
PURPOSE: Cognitive symptoms are common after cancer, but poorly associated with neuropsychological results. We previously reported colorectal cancer (CRC) patients had more cognitive impairment than controls. Here, we explore relationships between cognitive symptoms and neuropsychological domains. METHODS: Subjects with CRC (N = 362) and 72 healthy controls completed neuropsychological assessments and Functional Assessment of Cancer Therapy-Cognition (FACT-COG) at baseline (pre-chemotherapy) and 6, 12, and 24 months...
October 27, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29068797/alanine-aminotransferase-blood-levels-and-rehabilitation-outcome-in-older-adults-following-hip-fracture-surgery
#14
Irina Gringauz, Jonathan Weismann, Dan Justo, Abraham Adunsky, Gad Segal
Low alanine aminotransferase (ALT) blood levels are associated with frailty and poor outcome in older adults. Therefore, we studied the association between ALT blood levels before rehabilitation and rehabilitation outcome in older adults following hip fracture surgery. A total of 490 older adults (age>60 years, mean age: 82.9±6.7 years, 82.0% women) admitted to rehabilitation following hip fracture surgery were included. The rehabilitation outcome was assessed by Functional Independence Measure (FIM) scores...
October 24, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29067581/serial-intermediate-term-quality-of-life-comparison-after-endoscopic-submucosal-dissection-versus-surgery-in-early-gastric-cancer-patients
#15
Young-Il Kim, Young Ae Kim, Chan Gyoo Kim, Keun Won Ryu, Young-Woo Kim, Jin Ah Sim, Young Ho Yun, Il Ju Choi
BACKGROUND: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is expected to provide better long-term health-related quality of life (HRQOL) by preserving the entire stomach. We aimed to compare serial changes in HRQOL characteristics between patients who underwent ESD versus surgery for EGC. METHODS: A gastric cancer patient cohort was prospectively enrolled from 2004 to 2007. HRQOL of 161 EGC patients was prospectively assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30) and the stomach cancer-specific module EORTC-QLQ-STO22 at baseline (i...
October 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29048571/pain-in-survivors-of-pediatric-cancer-applying-a-prevention-framework
#16
Amanda L Stone, Cynthia W Karlson, Lauren C Heathcote, Abby R Rosenberg, Tonya M Palermo
To apply a biopsychosocial framework to understand factors influencing pain in survivors of pediatric cancer to inform pain prevention efforts and highlight the need for interdisciplinary care. This topical review draws from both pediatric cancer survivorship research and chronic noncancer pain research to illustrate how components of a preventative model can be applied to pain in survivorship. Pain is a common experience among long-term survivors of pediatric cancer. The pain experience in survivorship can be conceptualized in terms of biological disease and treatment factors, cognitive and affective factors, and social and contextual factors...
August 31, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29037753/cancer-related-cognitive-impairment-considering-risk-factors-approaching-assessment-and-contemplating-treatment
#17
EDITORIAL
Robin E Valpey
No abstract text is available yet for this article.
December 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29034740/efficacy-and-safety-of-the-traditional-herbal-medicine-gamiguibi-tang-in-patients-with-cancer-related-sleep-disturbance-a-prospective-randomized-wait-list-controlled-pilot-study
#18
Jee Young Lee, Hye Kyung Oh, Han Sung Ryu, Sung Soo Yoon, Wankyu Eo, Seong Woo Yoon
BACKGROUND: Sleep disturbance is the second most bothersome symptom in patients with cancer, and it can significantly impair their quality of life. The aim of this study was to investigate the efficacy and safety of the traditional herbal medicine Gamiguibi-tang (GGBT) in patients with cancer-related sleep disturbance. METHODS: We conducted a prospective, randomized, wait-list-controlled, open-label pilot clinical trial on cancer-related sleep disturbance. Patients with cancer experiencing poor sleep quality with a Pittsburgh Sleep Quality Index of at least 6 were randomly assigned to the GGBT and wait-list groups to receive GGBT and conventional care, respectively, for 2 weeks...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29029466/a-comparative-study-of-anti-aging-properties-and-mechanism-resveratrol-and-caloric-restriction
#19
Juan Li, Chun-Xia Zhang, Yi-Mei Liu, Ke-Li Chen, Gang Chen
Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated in vitro and in vivo. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027602/combining-risk-communication-strategies-to-simultaneously-convey-the-risks-of-four-diseases-associated-with-physical-inactivity-to-socio-demographically-diverse-populations
#20
Eva Janssen, Robert A C Ruiter, Erika A Waters
A single risk factor can increase the risk of developing multiple diseases, but most risk communication research has been conducted in the context of a single disease. We explored which combination of three recommended risk communication strategies is most effective in simultaneously conveying risk estimates of four diseases associated with physical inactivity: colon cancer, stroke, diabetes, and heart disease. Participants (N = 1161, 50% no college experience, 50% racial/ethnic minority) were shown hypothetical risk estimates for each of the four diseases...
October 13, 2017: Journal of Behavioral Medicine
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