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cancer related cognitive impairment

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https://www.readbyqxmd.com/read/29907436/a-call-for-a-neuroscience-approach-to-cancer-related-cognitive-impairment
#1
Todd S Horowitz, Jerry Suls, Melissa Treviño
Cancer-related cognitive impairment (CRCI) is a widespread problem for the increasing population of cancer survivors. Our understanding of the nature, causes, and prevalence of CRCI is hampered by a reliance on clinical neuropsychological methods originally designed to detect focal lesions. Future progress will require collaboration between neuroscience and clinical neuropsychology.
May 23, 2018: Trends in Neurosciences
https://www.readbyqxmd.com/read/29904964/self-reported-chemotherapy-related-cognitive-impairment-compared-with-cognitive-complaints-following-menopause
#2
Jennifer N Vega, Julie Dumas, Paul Newhouse
OBJECTIVE: Cancer-related cognitive impairment (CRCI) is commonly reported following the administration of cancer treatment. Current longitudinal studies, primarily in women with breast cancer, suggest that up to 35%-60% of patients exhibit persistent CRCI (pCRCI) following completion of chemotherapy. Complaints of subjective cognitive decline (SCD) are also commonly reported by women during and following the menopause transition in non-cancer patients. Although the majority of evidence for cognitive difficulties in cancer patients and survivors is attributed to chemotherapy, there is growing evidence to suggest that menopausal status can also influence cognitive function in cancer patients...
June 15, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29887785/physical-activity-exercise-and-breast-cancer-what-is-the-evidence-for-rehabilitation-aftercare-and-survival-a-review
#3
REVIEW
Petra Wirtz, Freerk T Baumann
The current scientific field of exercise interventions in breast cancer is very large. Rehabilitation focuses on restoring or improving quality of life and thus on independence and participation in life. Hence, it is important to investigate exercise interventions in the setting of rehabilitation and aftercare. It is also necessary to determine the influence of physical activity or exercise therapy on the prevention of recurrence and mortality as well as on certain side effects of the disease and its medical treatment in rehabilitation...
April 2018: Breast Care
https://www.readbyqxmd.com/read/29884597/communication-about-geriatric-assessment-domains-in-advanced-cancer-settings-missed-opportunities
#4
Lisa M Lowenstein, Robert J Volk, Richard Street, Marie Flannery, Allison Magnuson, Ronald Epstein, Supriya G Mohile
OBJECTIVES: Older patients with advanced cancer often have age-related health issues (e.g., memory impairment) that influence their cancer treatment decisions. Communication about these age-related concerns can potentially lead to further assessment and subsequent clinical interventions to improve treatment decision-making and patients' quality of life. Yet, little is known about the communication of age-related concerns between oncologists, patients, and caregivers. MATERIALS AND METHODS: This study is a secondary analysis of data from the Values and Options in Cancer Care (VOICE) study...
June 5, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29880075/effectiveness-of-intraindividual-variability-in-detecting-subtle-cognitive-performance-deficits-in-breast-cancer-patients
#5
Barbara Collins, Gerard Widmann, Giorgio A Tasca
OBJECTIVES: The purpose of this study was to determine if intraindividual variability would be more sensitive than speed or accuracy in detecting subtle cancer-related cognitive disturbance. METHODS: Data were from a previous study in which 60 breast cancer (BC) patients underwent neuropsychological assessment before commencement of chemotherapy and again following each chemotherapy cycle. Sixty healthy controls were tested at equivalent intervals. Hierarchical linear modeling was used to compare the BC and control groups in terms of accuracy, mean reaction time, and intraindividual variability in reaction time on a computerized continuous performance test with three conditions: a simple reaction time task, a "1-back" task, and a "2-back" task...
June 8, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29807537/prevalence-and-characteristics-of-breakthrough-cancer-pain-in-an-outpatient-clinic-in-a-catalan-teaching-hospital-incorporation-of-the-edmonton-classification-system-for-cancer-pain-into-the-diagnostic-algorithm
#6
Jaume Canal-Sotelo, Javier Trujillano-Cabello, Philip Larkin, Núria Arraràs-Torrelles, Ramona González-Rubió, Mariona Rocaspana-Garcia, Eva Barallat-Gimeno
BACKGROUND: Breakthrough cancer pain (BTcP) is defined according to its principal characteristics: high intensity, short time interval between onset and peak intensity, short duration, potential recurrence over 24 h and non-responsiveness to standard analgesic regimes. The Edmonton Classification System for Cancer Pain (ECS-CP) is a classification tool that evaluates different dimensions of pain. The aim of this study was to measure prevalence and the main characteristics of BTcP in a sample of advanced cancer patients and to explore the complexity observed when ECS-CP is incorporated into BTcP diagnostics algorithm...
May 28, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29806502/effects-of-acupuncture-on-cancer-related-cognitive-impairment-in-chinese-gynecological-cancer-patients-a-pilot-cohort-study
#7
Yingchun Zeng, Andy S K Cheng, Ting Song, Xiujie Sheng, Shaojing Wang, Jianfei Xie, Chetwyn C H Chan
BACKGROUND: Among women in China, gynecological cancers are the second most common cancers after breast cancer. Cancer-related cognitive impairment (CRCI) has emerged as a significant problem affecting gynecological cancer survivors. While acupuncture has been used in different aspects of cancer care, the possible positive effects of acupuncture on cognitive impairment have received little attention. This study hypothesized that patients would demonstrate lower neurocognitive performance and lower structural connectivity compared to healthy controls...
May 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29805744/oxaliplatin-induced-blood-brain-barrier-loosening-a-new-point-of-view-on-chemotherapy-induced-neurotoxicity
#8
Jacopo Junio Valerio Branca, Mario Maresca, Gabriele Morucci, Matteo Becatti, Ferdinando Paternostro, Massimo Gulisano, Carla Ghelardini, Daniela Salvemini, Lorenzo Di Cesare Mannelli, Alessandra Pacini
Oxaliplatin is a key drug in the treatment of advanced metastatic colorectal cancer. Despite its beneficial effects in tumor reduction, the most prevalent side-effect of oxaliplatin treatment is a chemotherapy-induced neuropathy that frequently forces to discontinue the therapy. Indeed, along with direct damage to peripheral nerves, the chemotherapy-related neurotoxicity involves also the central nervous system (CNS) as demonstrated by pain chronicity and cognitive impairment (also known as chemobrain), a newly described pharmacological side effect...
May 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/29774475/neuropsychological-profiles-of-breast-cancer-and-brain-tumor-cohorts-in-northeast-ontario-canada
#9
Matias Mariani, Mark William Glister Collins
PURPOSE: As developments in cancer treatment have improved outcomes, research has increasingly focused on the role of cancer-related cognitive impairment (CRCI) in quality of life for cancer survivors. Impairment profiles have been heterogeneous across studies, necessitating the study of these effects across different cohorts. The purpose of this preliminary study is to compare the memory profiles of Northeast Ontario breast and CNS cancer patients, as there is no literature which exists for profiling CRCI within this largely rural region...
May 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29759139/identifying-cytokine-predictors-of-cognitive-functioning-in-breast-cancer-survivors-up-to-10-years-post-chemotherapy-using-machine-learning
#10
Ashley M Henneghan, Oxana Palesh, Michelle Harrison, Shelli R Kesler
INTRODUCTION: The purpose of this study is to explore 13 cytokine predictors of chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors (BCS) 6 months to 10 years after chemotherapy completion using a multivariate, non-parametric approach. METHODS: Cross sectional data collection included completion of a survey, cognitive testing, and non-fasting blood from 66 participants. Data were analyzed using random forest regression to identify the most significant predictors for each of the cognitive test scores...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29758558/mild-cognitive-impairment-and-dementia-show-contrasting-associations-with-risk-of-cancer
#11
Kimberly D van der Willik, Rikje Ruiter, Frank J Wolters, M Kamran Ikram, Bruno H Stricker, Michael Hauptmann, Annette Compter, Sanne B Schagen, M Arfan Ikram
BACKGROUND: To investigate and to compare the relation between dementia and cancer with the association between mild cognitive impairment (MCI) and cancer. METHODS: A total of 13,207 persons from the Rotterdam Study were followed between 1990 and 2013 for the onset of dementia and cancer (sample 1). Between 2002 and 2005, a subset of 5,181 persons underwent extensive cognitive testing for MCI and subsequently were followed up for cancer until 2013 (sample 2). We used Cox proportional hazard models to determine the association between dementia and cancer, and MCI and cancer...
May 14, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29755682/evaluation-of-the-impact-of-s-adenosylmethionine-dependent-methyltransferase-inhibitor-3-deazaneplanocin-a-on-tissue-injury-and-cognitive-function-in-mice
#12
Eva Lhuissier, Juliette Aury-Landas, Valentine Bouet, Céline Bazille, Yohann Repesse, Thomas Freret, Karim Boumédiene, Catherine Baugé
Cancer patients display cognitive impairment due, at least partly, to the treatments. Additionally, chemotherapeutic treatments can lead to organ injury, limiting their use, and are likely to have negative impacts on patients' quality of life. The aim of this study was to investigate the toxicity of 3-Deazaneplanocin A (DZNep) on several tissues and organs, as well as on cognitive functions. DZNep is an inhibitor of S-adenosylmethionine-dependent methyltransferase (in particular of the histone methyltransferase EZH2) which showed antitumoral functions in preclinical trials but whose effects on behavior and on organs (side effects) are not known...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29740782/quality-of-life-problems-and-needs-of-disease-free-breast-cancer-survivors-5-years-after-diagnosis
#13
Martina E Schmidt, Joachim Wiskemann, Karen Steindorf
PURPOSE: After cancer treatment, it is desirable to maintain or regain a high quality of life (QoL) and the ability to accomplish everyday tasks well. Therefore, we substantiated the scarce knowledge regarding long-term QoL after breast cancer, burdensome problems, and unmet needs for more support. METHODS: Disease-free breast cancer survivors (n = 190) who had participated in two randomized controlled exercise trials during primary treatment were followed up to 5 years post-diagnosis...
May 8, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29735975/efficacy-of-acupuncture-therapy-for-chemotherapy-related-cognitive-impairment-in-breast-cancer-patients
#14
Taishan Tong, Chunqin Pei, Jun Chen, Qing Lv, Fuquan Zhang, Zaohuo Cheng
BACKGROUND Chemotherapy can cause adverse effects such as chemotherapy-related cognitive impairment (CRCI). In this prospective study, the efficacy of traditional Chinese medicine acupuncture therapy in relieving CRCI and its impact on serum brain-derived neurotrophic factor (BDNF) are evaluated. MATERIAL AND METHODS Eighty patients were randomly divided into a treatment group and a control group with 40 patients in each group. The treatment group was treated at the following acupuncture points: Baihui (DU20), Sishencong (EX-HN1), Shenting (DU24), Zusanli (ST36), Taixi (K13), Dazhong (K14), and Juegu (GB39)...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29705851/mouse-testing-methods-in-psychoneuroimmunology-2-0-measuring-behavioral-responses
#15
Albert E Towers, Jason M York, Tracy Baynard, Stephen J Gainey, Gregory G Freund
The field of psychoneuroimmunology (PNI) aims to uncover the processes and consequences of nervous, immune, and endocrine system relationships. Behavior is a consequence of such interactions and manifests from a complex interweave of factors including immune-to-neural and neural-to-immune communication. Often the signaling molecules involved during a particular episode of neuroimmune activation are not known but behavioral response provides evidence that bioactives such as neurotransmitters and cytokines are perturbed...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29680585/functional-and-cognitive-impairment-social-functioning-frailty-and-adverse-health-outcomes-in-older-patients-with-esophageal-cancer-a-systematic-review
#16
Floor J van Deudekom, Henk G Klop, Henk H Hartgrink, Jurjen J Boonstra, Irene M Lips, Marije Slingerland, Simon P Mooijaart
BACKGROUND: Older patients with esophageal cancer are at high risk of adverse health outcomes, but the association of geriatric assessment with adverse health outcomes in these patients has not been systematically evaluated. The aim of this systematic review was to study the association of functional and cognitive impairment, social environment and frailty with adverse health outcomes in patients diagnosed with esophageal cancer. METHODS: We searched Pubmed, Embase, Web of Science and Cochrane Library for original studies reporting on associations of functional or cognitive impairment, social environment and frailty with adverse outcomes (mortality, functional or cognitive decline, adverse events during treatment, prolonged length of hospitalization (LOS) and health related quality of life (HRQoL)) after follow-up in patients with esophageal cancer...
April 19, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29675944/advanced-mr-diffusion-imaging-and-chemotherapy-related-changes-in-cerebral-white-matter-microstructure-of-survivors-of-childhood-bone-and-soft-tissue-sarcoma
#17
Charlotte Sleurs, Jurgen Lemiere, Daan Christiaens, Thibo Billiet, Ronald Peeters, Stefan Sunaert, Anne Uyttebroeck, Sabine Deprez
With the increase of survival rates of pediatric cancer patients, the number of children facing potential cognitive sequelae has grown. Previous adult studies suggest that white matter (WM) microstructural changes may contribute to cognitive impairment. This study aims to investigate WM microstructure in childhood bone and soft tissue sarcoma. Differences in (micro-)structure can be investigated using diffusion MRI (dMRI). The typically used diffusion tensor model (DTI) assumes Gaussian diffusion, and lacks information about fiber populations...
April 20, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29663137/health-related-quality-of-life-among-cancer-patients-in-their-last-year-of-life-results-from-the-profiles-registry
#18
Natasja J H Raijmakers, M Zijlstra, J van Roij, O Husson, S Oerlemans, L V van de Poll-Franse
PURPOSE: The aim of this study was to assess health-related quality of life (HRQoL) in the last year of life of cancer patients stratified by four periods of time before death. PATIENTS AND METHODS: Between 2008 and 2015, cancer patients were invited to participate in PROFILES (Patient Reported Outcomes Following Initial Treatment and Long-term Evaluation of Survivorship) registry studies. Patients were eligible for inclusion in this secondary analysis if they had been invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) in their last year of life (N = 892)...
April 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29617869/changes-in-brain-structural-networks-and-cognitive-functions-in-testicular-cancer-patients-receiving-cisplatin-based-chemotherapy
#19
Ali Amidi, S M Hadi Hosseini, Alexander Leemans, Shelli R Kesler, Mads Agerbæk, Lisa M Wu, Robert Zachariae
Background: Cisplatin-based chemotherapy may have neurotoxic effects within the central nervous system. The aims of this study were 1) to longitudinally investigate the impact of cisplatin-based chemotherapy on whole-brain networks in testicular cancer patients undergoing treatment and 2) to explore whether possible changes are related to decline in cognitive functioning. Methods: Sixty-four newly orchiectomized TC patients underwent structural magnetic resonance imaging (T1-weighted and diffusion-weighted imaging) and cognitive testing at baseline prior to further treatment and again at a six-month follow-up...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29578249/preoperative-vitamin-d-deficiency-increases-the-risk-of-postoperative-cognitive-dysfunction-a-predefined-exploratory-sub-analysis
#20
Y Zhang, G-J Shan, Y-X Zhang, S-J Cao, S-N Zhu, H-J Li, D Ma, D-X Wang
BACKGROUND: Vitamin D is important for maintaining physiological functions including cognition and its deficiency is associated with the occurrence of cognitive impairment. This study was to explore the association between preoperative vitamin D status and the occurrence of postoperative cognitive dysfunction (POCD) in elderly patients undergoing major surgery. METHODS: This was a predefined exploratory sub-analysis of one-centre data from a randomized controlled trial...
March 26, 2018: Acta Anaesthesiologica Scandinavica
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