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https://www.readbyqxmd.com/read/29048571/pain-in-survivors-of-pediatric-cancer-applying-a-prevention-framework
#1
Amanda L Stone, Cynthia W Karlson, Lauren C Heathcote, Abby R Rosenberg, Tonya M Palermo
To apply a biopsychosocial framework to understand factors influencing pain in survivors of pediatric cancer to inform pain prevention efforts and highlight the need for interdisciplinary care. This topical review draws from both pediatric cancer survivorship research and chronic noncancer pain research to illustrate how components of a preventative model can be applied to pain in survivorship. Pain is a common experience among long-term survivors of pediatric cancer. The pain experience in survivorship can be conceptualized in terms of biological disease and treatment factors, cognitive and affective factors, and social and contextual factors...
August 31, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29037753/cancer-related-cognitive-impairment-considering-risk-factors-approaching-assessment-and-contemplating-treatment
#2
EDITORIAL
Robin E Valpey
No abstract text is available yet for this article.
September 20, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29034740/efficacy-and-safety-of-the-traditional-herbal-medicine-gamiguibi-tang-in-patients-with-cancer-related-sleep-disturbance-a-prospective-randomized-wait-list-controlled-pilot-study
#3
Jee Young Lee, Hye Kyung Oh, Han Sung Ryu, Sung Soo Yoon, Wankyu Eo, Seong Woo Yoon
BACKGROUND: Sleep disturbance is the second most bothersome symptom in patients with cancer, and it can significantly impair their quality of life. The aim of this study was to investigate the efficacy and safety of the traditional herbal medicine Gamiguibi-tang (GGBT) in patients with cancer-related sleep disturbance. METHODS: We conducted a prospective, randomized, wait-list-controlled, open-label pilot clinical trial on cancer-related sleep disturbance. Patients with cancer experiencing poor sleep quality with a Pittsburgh Sleep Quality Index of at least 6 were randomly assigned to the GGBT and wait-list groups to receive GGBT and conventional care, respectively, for 2 weeks...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29029466/a-comparative-study-of-anti-aging-properties-and-mechanism-resveratrol-and-caloric-restriction
#4
Juan Li, Chun-Xia Zhang, Yi-Mei Liu, Ke-Li Chen, Gang Chen
Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated in vitro and in vivo. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027602/combining-risk-communication-strategies-to-simultaneously-convey-the-risks-of-four-diseases-associated-with-physical-inactivity-to-socio-demographically-diverse-populations
#5
Eva Janssen, Robert A C Ruiter, Erika A Waters
A single risk factor can increase the risk of developing multiple diseases, but most risk communication research has been conducted in the context of a single disease. We explored which combination of three recommended risk communication strategies is most effective in simultaneously conveying risk estimates of four diseases associated with physical inactivity: colon cancer, stroke, diabetes, and heart disease. Participants (N = 1161, 50% no college experience, 50% racial/ethnic minority) were shown hypothetical risk estimates for each of the four diseases...
October 13, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28992858/cognitive-changes-related-to-cancer-therapy
#6
REVIEW
Tracy D Vannorsdall
A growing population of cancer survivors is at risk for acute and long-term consequences resulting from cancer and its treatment. Cancer-related cognitive impairment (CRCI) typically manifests as modest deficits in attention, processing speed, executive functioning, and memory, which may persist for decades after treatment. Although some risk factors for CRCI are largely immutable (eg, genetics and demographic factors), there are many other contributors to CRCI that when appropriately addressed can result in improved cognitive functioning and quality of life...
November 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/28972834/how-we-care-for-an-older-patient-with-cancer
#7
Armin Shahrokni, Soo Jung Kim, George J Bosl, Beatriz Korc-Grodzicki
As the number of older patients with cancer is increasing, oncology disciplines are faced with the challenge of managing patients with multiple chronic conditions who have difficulty maintaining independence, who may have cognitive impairment, and who also may be more vulnerable to adverse outcomes. National and international societies have recommended that all older patients with cancer undergo geriatric assessment (GA) to detect unaddressed problems and introduce interventions to augment functional status to possibly improve patient survival...
February 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28942911/making-cancer-rehabilitation-services-work-for-cancer-patients-recommendations-for-research-and-practice-to-improve-employment-outcomes
#8
REVIEW
Catherine M Alfano, Erin E Kent, Lynne S Padgett, Melvin Grimes, Janet S de Moor
Cancer and its treatment can result in impairments that limit physical, psychosocial, and cognitive functioning, interfering with patients' ability to perform work-related functions. Because these work limitations can carry significant personal and societal costs, there is a timely need to identify and refer patients to cancer rehabilitation services to manage adverse consequences of treatment and to preserve employment. Coordinated efforts in 3 key areas will better connect patients to rehabilitation interventions that will help optimize employment...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28883718/contributions-of-copd-asthma-and-ten-comorbid-conditions-to-health-care-utilization-and-patient-centered-outcomes-among-us-adults-with-obstructive-airway-disease
#9
Terrence E Murphy, Gail J McAvay, Heather G Allore, Jason A Stamm, Paul F Simonelli
BACKGROUND: Among persons with obstructive airway disease, the relative contributions of chronic obstructive pulmonary disease (COPD), asthma, and common comorbid conditions to health care utilization and patient-centered outcomes (PCOs) have not been previously reported. METHODS: We followed a total of 3,486 persons aged ≥40 years with COPD, asthma, or both at baseline, from the Medical Expenditure Panel Survey (MEPS) cohorts enrolled annually from 2008 through 2012 for 1 year...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28864864/the-anticancer-estrogen-receptor-antagonist-tamoxifen-impairs-consolidation-of-inhibitory-avoidance-memory-through-estrogen-receptor-alpha
#10
Martina Lichtenfels, Arethuza da Silva Dornelles, Fernanda Dos Santos Petry, Martina Blank, Caroline Brunetto de Farias, Rafael Roesler, Gilberto Schwartsmann
Over two-thirds of women with breast cancer have positive tumors for hormone receptors, and these patients undergo treatment with endocrine therapy, tamoxifen being the most widely used agent. Despite being very effective in breast cancer treatment, tamoxifen is associated with side effects that include cognitive impairments. However, the specific aspects and mechanisms underlying these impairments remain to be characterized. Here, we have investigated the effects of tamoxifen and interaction with estrogen receptors on formation of memory for inhibitory avoidance conditioning in female rats...
September 2, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28845551/management-of-side-effects-during-and-post-treatment-in-breast-cancer-survivors
#11
Oxana Palesh, Caroline Scheiber, Shelli Kesler, Karen Mustian, Cheryl Koopman, Lidia Schapira
Cancer-related fatigue, insomnia, and cancer-related cognitive impairment are commonly experienced symptoms that share psychological and physical manifestations. One or more of these symptoms will affect nearly all patients at some point during their course of treatment or survivorship. These side effects are burdensome and reduce patients' quality of life well beyond their cancer diagnosis and associated care treatments. Cancer-related fatigue, insomnia, and cancer-related cognitive impairment are likely to have multiple etiologies that make it difficult to identify the most effective method to manage them...
August 27, 2017: Breast Journal
https://www.readbyqxmd.com/read/28835219/clinical-decision-making-and-health-related-quality-of-life-during-first-line-and-maintenance-therapy-in-patients-with-advanced-non-small-cell-lung-cancer-nsclc-findings-from-a-real-world-setting
#12
Monika Sztankay, Johannes Maria Giesinger, August Zabernigg, Elisabeth Krempler, Georg Pall, Wolfgang Hilbe, Otto Burghuber, Maximilian Hochmair, Gerhard Rumpold, Stephan Doering, Bernhard Holzner
BACKGROUND: Maintenance therapy (MT) with pemetrexed has been shown to improve overall and progression-free survival of patients with non-squamous non-small cell lung cancer (NSCLC), without impairing patients' health-related quality of life (HRQOL) substantially. Comprehensive data on HRQOL under real-life conditions are necessary to enable informed decision-making. This study aims to (1) assess HRQOL during first-line chemotherapy and subsequent MT and (2) record patients' and physicians' reasons leading to clinical decisions on MT...
August 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28830646/dynamics-of-patient-reported-quality-of-life-and-symptoms-in-the-acute-phase-of-online-adaptive-external-beam-radiation-therapy-for-locally-advanced-cervical-cancer
#13
S T Heijkoop, R A Nout, S Quint, J W M Mens, B J M Heijmen, M S Hoogeman
OBJECTIVE: For locally advanced cervical cancer patients, treated with External Beam Radiotherapy (EBRT), Quality of Life (QoL) questionnaires arefrequently used to evaluate treatment-related symptoms and functioning scales. Currently, it is unknown how those evolve during the radiation treatment course. In this prospective study we report on weekly-captured patient-reported QoL and symptoms during image-guided adaptive radiotherapy (IGART) of cervical cancer patients. MATERIAL AND METHODS: Between January 2012 and September 2016, all locally advanced cervical cancer patients treated with IGART and brachytherapy with or without chemotherapy or hyperthermia, were eligible...
August 19, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28830202/radiological-distribution-of-brain-metastases-and-it-s-implication-for-the-hippocampus-avoidance-in-whole-brain-radiotherapy-approach
#14
Yi-Min Han, Gang Cai, Wei-Min Chai, Cheng Xu, Lu Cao, Dan Ou, Jia-Yi Chen, Youlia M Kirova
PURPOSE: Hippocampus avoidance in whole brain radiotherapy (HA-WBRT) offers the feasibility of less impaired cognitive function than conventional WBRT. The study aims to assess the radiological distribution of BMs with relation to the hippocampus and peri-hippocampus(PH) region as defined by the RTOG 0933 for better understanding of margin definition in HA-WBRT treatment planning. METHODS: Consecutive patients with diagnosis of BM from enhanced MRI between 03/2011 and 07/2016 were analyzed...
August 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28816636/the-distress-thermometer-predicts-subjective-but-not-objective-cognitive-complaints-six-months-after-treatment-initiation-in-cancer-patients-receiving-a-curative-cancer-treatment
#15
Michelle Lycke, Tessa Lefebvre, Lies Pottel, Hans Pottel, Lore Ketelaars, Karin Stellamans, Koen Van Eygen, Philippe Vergauwe, Patrick Werbrouck, Laurence Goethals, Patricia Schofield, Tom Boterberg, Philip R Debruyne
OBJECTIVES: Research has indicated that cancer-related cognitive impairments (CRCI) may be influenced by psychosocial factors such as distress, worry and fatigue. Therefore, we aimed to validate the distress thermometer (DT) as a screening tool to detect CRCI six months post treatment initiation in a group of general cancer patients. METHODS: Patients(18 years, n 125) with a histologically confirmed diagnosis of a solid cancer or haematological malignancy, scheduled for a curative treatment, were evaluated at baseline (T0) and six months post-treatment initiation (T1) for CRCI by a neuropsychological assessment including patient-reported outcome measures (PROMs)...
August 17, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28807816/mtor-in-down-syndrome-role-in-a%C3%A3-and-tau-neuropathology-and-transition-to-alzheimer-disease-like-dementia
#16
REVIEW
Fabio Di Domenico, Antonella Tramutola, Cesira Foppoli, Elizabeth Head, Marzia Perluigi, D Allan Butterfield
The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase involved in the regulation of protein synthesis and degradation, longevity and cytoskeletal formation. The mTOR pathway represents a key growth and survival pathway involved in several diseases such as cancer, obesity, cardiovascular disease and neurodegenerative diseases. Numerous studies linked the alterations of mTOR pathway to age-dependent cognitive decline, pathogenesis of Alzheimer disease (AD) and AD-like dementia in Down syndrome (DS)...
August 12, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28797784/the-role-of-age-in-neurocognitive-functioning-among-adult-allogeneic-hematopoietic-cell-transplant-recipients
#17
Aasha I Hoogland, Ashley M Nelson, Brent J Small, Kelly A Hyland, Brian D Gonzalez, Margaret Booth-Jones, Claudio Anasetti, Paul B Jacobsen, Heather S L Jim
Improvements in supportive care have enabled allogeneic hematopoietic cell transplantation (HCT) to be performed in increasingly older patients. HCT is associated with neurocognitive impairment, which may be exacerbated in older adults due to normal neurocognitive decline associated with aging. The goal of this study was to evaluate whether increasing age of allogeneic HCT recipients is associated with worse neurocognitive outcomes over time relative to a matched sample of individuals without cancer. Patients (n = 140; 42% female; M age, 51 years; range, 20 to 76 years; 31% with acute myelogenous leukemia) completed neurocognitive assessments before transplantation and 3 months and 1 year after transplantation...
August 7, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28795857/unmet-needs-of-adult-survivors-of-childhood-cancers-associations-with-developmental-stage-at-diagnosis-cognitive-impairment-and-time-from-diagnosis
#18
Joanne L Park, Yvonne Brandelli, K Brooke Russell, Kathleen Reynolds, Yong Li, Dean Ruether, Janine Giese-Davis
PURPOSE: Adult survivors of childhood cancers (ASCCs) are a unique and growing population. Because these individuals were diagnosed in childhood, their developmental stage at diagnosis may influence medical sequelae and perception of their cancer diagnosis and potentially result in long-term complications and challenges. Our aim was to determine how developmental stage, time since diagnosis, and cognitive impairment relate to Canadian ASCC distress and unmet needs. METHODS: Canadian ASCCs aged 19-77 years (N = 115) diagnosed between ages 0 and 5 (n = 25), 6 and 12 (n = 22), or 13 and 18 (n = 68) completed demographic, neurocognitive self-report, depression, and anxiety and unmet needs questionnaires...
August 10, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28748850/correlation-between-electroencephalogram-alterations-and-frontal-cognitive-impairment-in-esophageal-cancer-patients-complicated-with-depression
#19
Yin Cao, Xia Chen, Hui Xie, Ling Zou, Li-Jun Hu, Xian-Ju Zhou
BACKGROUND: Some esophageal cancer patients complicated with depression exhibit cognitive impairments. Frontal electroencephalogram (EEG) may be used as a reliable biomarker for prefrontal-mediated cognitive functions. This study was to investigate alterations of EEG and frontal cognitive impairment in esophageal cancer patients complicated with depression and to assess their correlation. METHODS: Sixty-five esophageal cancer patients with depression (study group) and 62 healthy controls (control group) were included in this study...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28723499/prospective-evaluation-of-the-impact-of-antiangiogenic-treatment-on-cognitive-functions-in-metastatic-renal-cancer
#20
Florence Joly, Natacha Heutte, Brigitte Duclos, Sabine Noal, Isabelle Léger-Hardy, Sarah Dauchy, Nadine Longato, Laurence Desrues, Nadine Houede, Marie Lange, Emmanuel Sevin, Chantal Rieux, Bénédicte Clarisse, Hélène Castel, Bernard Escudier
BACKGROUND: Little is known about the cognitive effects of antiangiogenic therapies (AATs) in metastatic renal cell carcinoma (mRCC) and their relation with fatigue. OBJECTIVE: To evaluate the impact of AATs on cognition and its connection with fatigue and quality of life (QoL) in patients with mRCC. DESIGN, SETTING, AND PARTICIPANTS: This prospective study enrolled 75 patients starting AAT as first or second line for mRCC and assessed them at 3 mo (n=58) and 6 mo (n=50)...
December 15, 2016: European Urology Focus
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