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https://www.readbyqxmd.com/read/28944509/diagnosis-and-treatment-of-patients-with-prostatic-abscess-in-the-post-antibiotic-era
#1
REVIEW
Anne Lenore Ackerman, Pooja S Parameshwar, Jennifer T Anger
We reviewed the pathogenesis, clinical presentation, treatment options and outcomes of prostatic abscess in the post-antibiotic era, focusing on how patient risk factors and the emergence of multidrug-resistant organisms influence management of the condition. A MEDLINE search for "prostate abscess" or "prostatic abscess" was carried out. Prostate abscess is no longer considered a consequence of untreated urinary infection; now, men with prostatic abscess are typically debilitated or immunologically compromised, with >50% of patients having diabetes...
September 24, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28944199/comparative-analysis-of-cytomegalovirus-retinitis-and-microvascular-retinopathy-in-patients-with-acquired-immunodeficiency-syndrome
#2
Chao Chen, Chun-Gang Guo, Li Meng, Jing Yu, Lian-Yong Xie, Hong-Wei Dong, Wen-Bin Wei
AIM: To compare the clinical manifestation of cytomegalovirus (CMV) retinitis and microvascular retinopathy (MVR) in patients with acquired immunodeficiency syndrome (AIDS) in China. METHODS: A total of 93 consecutive patients with AIDS, including 41 cases of CMV retinitis and 52 cases of MVR were retrospectively reviewed. Highly active antiretroviral therapy (HAART) status was recorded. HIV and CMV immunoassay were also tested. CD4+ T-lymphocyte count and blood CMV-DNA test were performed in all patients...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944144/osteomyelitis-due-to-multiple-rare-infections-in-a-patient-with-idiopathic-cd4-lymphocytopenia
#3
Nitin Gupta, Sayantan Banerjee, Timitrov, Rohini Sharma, Shambo Guha Roy, Trupti M Shende, Mohammed Tahir Ansari, Gagandeep Singh, Neeraj Nischal, Naveet Wig, Manish Soneja
A 26-year-old male patient presented with features suggestive of osteomyelitis involving the entire left femur, hip joint and knee joint. Culture from the debrided tissue grew Acinetobacter spp. and he was treated with sensitivity based antibiotics but the symptoms did not resolve. The synovial biopsy showed multinucleated giant cells and acid fast bacilli on Ziehl Neelsen stain. Cartridge based nucleic acid amplification test (GeneXpert) was negative. The Mycobacteria growth indicator tube culture was found to be positive for Mycobacterium abscessus...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28944123/preventing-cushing-iatrogenic-cushing-syndrome-due-to-ritonavir-fluticasone-interaction
#4
Fasil Tiruneh, Ahmad Awan, Abiot Didana, Saumil Doshi
Ritonavir is commonly used in low doses to boost plasma levels of protease inhibitors in patients with human immunodeficiency virus (HIV) infections. It is also a potent inhibitor of cytochrome P450. We present a 50-year-old African American male with past medical history of HIV on highly active antiretroviral therapy (HAART), which also included ritonavir and long standing asthma that has been treated with inhaled fluticasone, who presented with back pain. He had central obesity, prominent abdominal striae and wasted extremities on physical examination...
July 17, 2017: Curēus
https://www.readbyqxmd.com/read/28944075/efficacy-of-switching-to-dolutegravir-plus-rilpivirine-the-small-tablet-regimen-in-patients-with-dysphagia-two-case-reports
#5
Takefumi Suzuki, Nobuko Hara, Morichika Osa, Kazuhisa Misawa, Kazuo Imai, Yuji Fujikura, Takuya Maeda, Wataru Sonehara, Akihiko Kawana
BACKGROUND: The advent of well-tolerated and effective anti-retroviral drugs against human immunodeficiency virus-1 (HIV-1) infection has been a major step forward that has achieved long-term survival in recent years. The number of HIV-1 infected patients who experience difficulty in swallowing tablets is expected to increase as the HIV-infected population advances in age or develops comorbidities or treatment sequelae affecting the central nervous system. CASE PRESENTATION: Here, we describe two HIV-1-infected patients who experienced progressive dysphagia leading to inability to swallow the antiretroviral tablets included in the standard regimen...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28943167/bordetella-bronchiseptica-infection
#6
M Ducours, P Rispal, M P Danjean, Y Imbert, E Dupont, E M Traissac, S Grosleron
OBJECTIVE: To collect data of all patients admitted to hospital with a positive test to Bordetella bronchiseptica between 2001 and 2015. METHODS: We performed a retrospective monocentric study of all hospitalized patients over the past 15 years with a positive test to B. bronchiseptica. RESULTS: Nine patients were included between 2001 and 2015; two presented with infectious relapses, i.e. a total of 14 positive test samples were observed...
September 21, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28942916/protective-effect-of-coffee-consumption-on-all-cause-mortality-of-french-hiv-hcv-co-infected-patients
#7
Maria Patrizia Carrieri, Camelia Protopopescu, Fabienne Marcellin, Silvia Rosellini, Linda Wittkop, Laure Esterle, David Zucman, François Raffi, Eric Rosenthal, Isabelle Poizot-Martin, Dominique Salmon-Ceron, François Dabis, Bruno Spire
BACKGROUND & AIMS: Coffee has anti-inflammatory and hepato-protective properties. In the general population, drinking ≥3cups of coffee/day has been associated with a 14% reduction in the risk of all-cause mortality. The aim of this study was to investigate the relationship between coffee consumption and the risk of all-cause mortality in patients co-infected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). METHODS: ANRS CO13 HEPAVIH is an ongoing French nationwide prospective cohort of patients co-infected with HIV-HCV collecting both medical and psychosocial/behavioural data (annual self-administered questionnaires)...
September 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28942732/is-graves-disease-a-primary-immunodeficiency-new-immunological-perspectives-on-an-endocrine-disease
#8
REVIEW
Tristan Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Mueller, Mike Recher, Philipp Schuetz
BACKGROUND: Uncertainty about factors influencing the susceptibility and triggers for Graves' disease persists, along with a wide variation in the response to anti-thyroid drugs, currently at approximately 50% of non-responders. The aim of this narrative review is to summarize immunological concepts, with a combined endocrine and immunological perspective, to highlight potential new areas of research. MAIN TEXT: Relevant studies were identified through a systematic literature search using the PubMed and EMBASE databases in March 2016...
September 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28942128/vascular-smooth-muscle-cells-derived-from-inbred-swine-induced-pluripotent-stem-cells-for-vascular-tissue-engineering
#9
Jiesi Luo, Lingfeng Qin, Mehmet H Kural, Jonas Schwan, Xia Li, Oscar Bartulos, Xiao-Qiang Cong, Yongming Ren, Liqiong Gui, Guangxin Li, Matthew W Ellis, Peining Li, Darrell N Kotton, Alan Dardik, Jordan S Pober, George Tellides, Marsha Rolle, Stuart Campbell, Robert J Hawley, David H Sachs, Laura E Niklason, Yibing Qyang
Development of autologous tissue-engineered vascular constructs using vascular smooth muscle cells (VSMCs) derived from human induced pluripotent stem cells (iPSCs) holds great potential in treating patients with vascular disease. However, preclinical, large animal iPSC-based cellular and tissue models are required to evaluate safety and efficacy prior to clinical application. Herein, swine iPSC (siPSC) lines were established by introducing doxycycline-inducible reprogramming factors into fetal fibroblasts from a line of inbred Massachusetts General Hospital miniature swine that accept tissue and organ transplants without immunosuppression within the line...
September 19, 2017: Biomaterials
https://www.readbyqxmd.com/read/28942047/the-course-of-infection-caused-by-encephalitozoon-cuniculi-genotype-iii-in-immunocompetent-and-immunodeficient-mice
#10
Michaela Kotková, Bohumil Sak, Lenka Hlásková, Martin Kváč
Encephalitozoon cuniculi is probably the most common microsporidia which infects a wide range of vertebrates, including human. So far, four genotypes of this parasite have been identified based on the rRNA internal transcribed spacer variations. The course of infection caused by E. cuniculi III had very massive onset in immunocompetent host characterized by the presence of this parasite in all organs and tissues within one week after peroral infection. Encephalitozoonosis caused by E. cuniculi III had very progressive spreading into all organs within first week post inoculation in immunocompromised SCID mice and led to the death of the host...
September 20, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28941859/a-rare-presentation-of-disseminated-tuberculosis-prostatic-abscess
#11
Ajay Verma, Anubhuti Singh, Kislay Kishore, Surya Kant
Involvement of the prostate by tuberculosis (TB) occurs rarely and tuberculosis prostate abscess is an even rarer occurrence. It has been reported in immunocompromised patients, mainly human immunodeficiency virus seropositive individuals. We are reporting a case of tuberculosis prostatic abscess in an immunocompetent patient with relapse of TB.
October 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28941857/a-cross-sectional-study-to-assess-the-stigma-associated-with-tuberculosis-among-tuberculosis-patients-in-udupi-district-karnataka
#12
R Shivapujimath, A P Rao, A R Nilima, D M Shilpa
BACKGROUND: For decades, tuberculosis and other communicable diseases like human immunodeficiency virus/acquired immune deficiency syndrome, leprosy, etc., have been associated with stigma and discrimination by the society; this can interfere with the lifestyle and disease management among these patients. OBJECTIVE: To assess the stigma experienced by tuberculosis patients and to find the factors associated with stigma. METHODS: A cross-sectional study was conducted among 209 sputum-positive and sputum-negative tuberculosis patients...
October 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28941537/immunoparalysis-in-pediatric-critical-care
#13
REVIEW
Mark W Hall, Kristin C Greathouse, Rajan K Thakkar, Eric A Sribnick, Jennifer A Muszynski
Although many forms of critical illness are initiated by a proinflammatory stimulus, a compensatory anti-inflammatory response can occur with systemic inflammation. Immunoparalysis, an important form of acquired immunodeficiency, affects the innate and adaptive arms of the immune system. Immunoparalysis has been associated with increased risks for nosocomial infection and death in a variety of pediatric critical illnesses. Evidence suggests that immunoparalysis is reversible with immunostimulants. Highly standardized, prospective immune monitoring regimens are needed to better understand the immunologic effects of critical care treatment regimens and to enrich clinical trials with subjects most likely to benefit from immunostimulatory therapies...
October 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28941319/donor-derived-kaposi-s-sarcoma-in-a-liver-kidney-transplant-recipient
#14
S C Dollard, D Douglas, S V Basavaraju, D S Schmid, M Kuehnert, B Aqel
Human herpes virus 8 (HHV-8), also known as Kaposi's sarcoma associated herpesvirus (KSHV), is an oncogenic virus that can cause Kaposi's sarcoma (KS). KS can develop following organ transplantation through reactivation of the recipient's latent HHV-8 infection, or less commonly through donor-derived infection which has higher risk for severe illness and mortality. We describe a case of probable donor-derived KS in the recipient of a liver-kidney transplant. The donor had multiple risk factors for HHV-8 infection...
September 23, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28941186/three-novel-mutations-in-cyba-among-22-iranians-with-chronic-granulomatous-disease
#15
M Badalzadeh, S Tajik, M R Fazlollahi, M Houshmand, F Fattahi, Z Alizadeh, M Movahedi, Z Adab, G T Khotaei, A A Hamidieh, H Heidarnazhad, Z Pourpak
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by defect in one of the components of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase enzyme. The enzyme is at least composed of membrane-bound subunits gp91-phox and p22-phox (also named cytochrome b558 ), and cytosolic ones p40-phox, p47-phox and p67-phox. A defect in the enzyme activity leads to impaired intracellular killing of phagocytic cells. The CYBA gene encoding p22-phox is located on chromosome 16q24. In this study, new genetic changes of CYBA gene in 22 Iranian patients with autosomal recessive-CGD (AR-CGD) were identified...
September 20, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28941161/from-clinical-observations-and-molecular-dissection-to-novel-therapeutic-strategies-for-primary-immunodeficiency-disorders
#16
REVIEW
Hans D Ochs, Daniel Petroni
The field of primary immunodeficiency diseases (PID) is rapidly expanding with more than 300 genetically defined disorders that have been clinically described and molecularly analyzed. The molecular dissection of these entities has led to the discovery of new immunologic pathways and to novel and effective disease-specific therapies. This review provides a summary of these primary immune defects categorized by clinical phenotype and molecular similarity as defined by the International Union of Immunologic Societies (IUIS) Expert Committee for PID...
September 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28941042/nanomaterials-in-the-prevention-diagnosis-and-treatment-of-mycobacterium-tuberculosis-infections
#17
REVIEW
Kaijin Xu, Zhen Chang Liang, Xin Ding, Haiyang Hu, Shaoqiong Liu, Martin Nurmik, Sheng Bi, Feishu Hu, Zhongkang Ji, Jingjing Ren, Shigui Yang, Yi Yan Yang, Lanjuan Li
Despite the tremendous advancements that have been made in biomedical research, Mycobacterium tuberculosis (TB) still remains one of the top 10 causes of death worldwide, outpacing the Human Immunodeficiency Virus as a leading cause of death from an infectious disease. In the light of such significant disease burden, tremendous efforts have been made worldwide to stem this burgeoning spread of disease. The use of nanomaterials in TB management has increased in the past decade, particularly in the areas of early TB detection, prevention, and treatment...
September 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28940864/the-22q11-2-deletion-syndrome-cancer-predisposition-platelet-abnormalities-and-cytopenias
#18
REVIEW
Michele P Lambert, Abinaya Arulselvan, Amanda Schott, Stephen J Markham, Terrance B Crowley, Elaine H Zackai, Donna M McDonald-McGinn
The 22q11.2 deletion syndrome (DS) is associated with variable phenotypic expression as findings range from severely affected individuals with the classical triad of DiGeorge and velocardiofacial syndromes, including congenital heart disease, immunodeficiency, hypocalcemia, and palatal abnormalities, to subtly affected adults who only come to attention following the diagnosis of a more severely affected child. The multiple manifestations can affect all organ systems, including the hematologic system resulting in baseline lower platelet counts for individuals with 22q11...
September 22, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28940154/elsulfavirine-first-global-approval
#19
Zaina T Al-Salama
Elsulfavirine (Elpida(®)) is a new-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) being developed by Viriom for the treatment and prevention of human immunodeficiency virus (HIV) infections. It is the prodrug of the active compound VM-1500A, a small molecule selective NNRTI, which prevents HIV replication. In June 2017, elsulfavirine received its first global approval in Russia for the treatment of HIV-1 infections in combination with other antiretroviral medicines. Other formulations of this drug are also being evaluated in preclinical and phase II studies for the treatment of HIV infections and/or pre-exposure and post-exposure prophylaxis...
September 23, 2017: Drugs
https://www.readbyqxmd.com/read/28939872/production-of-immunodeficient-rabbits-by-multiplex-embryo-transfer-and-multiplex-gene-targeting
#20
Jun Song, Dongshan Yang, Jinxue Ruan, Jifeng Zhang, Yuqing Eugene Chen, Jie Xu
Immunodeficient mice have been used predominantly in biomedical research. Realizing that large animal species may have an enhanced ability to predict clinical outcome relative to mice, we worked to develop immunodeficient rabbits by CRISPR/Cas9. We first demonstrated that multiplex embryo transfer efficiently produced multiple lines of single-gene mutant (SGM) founders. Embryos microinjected with single sgRNA targeting FOXN1, RAG2, IL2RG or PRKDC were pooled for embryo transfer. As few as three recipients were used to produce twenty SGM founders for four genes...
September 22, 2017: Scientific Reports
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