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https://www.readbyqxmd.com/read/28346030/antimicrobial-activity-of-eugenol-and-essential-oils-containing-eugenol-a-mechanistic-viewpoint
#1
Anna Marchese, Ramona Barbieri, Erika Coppo, Ilkay Erdogan Orhan, Maria Daglia, Seyed Fazel Nabavi, Morteza Izadi, Mohammad Abdollahi, Seyed Mohammad Nabavi, Marjan Ajami
Eugenol is a hydroxyphenyl propene, naturally occurring in the essential oils of several plants belonging to the Lamiaceae, Lauraceae, Myrtaceae, and Myristicaceae families. It is one of the major constituents of clove (Syzygium aromaticum (L.) Merr. & L.M. Perry, Myrtaceae) oil and is largely used in both foods and cosmetics as a flavoring agent. A large body of recent scientific evidence supports claims from traditional medicine that eugenol exerts beneficial effects on human health. These effects are mainly associated with antioxidant and anti-inflammatory activities...
March 27, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28345829/high-fluoroquinolone-resistant-strains-of-helicobacter-pylori-in-the-golden-triangle
#2
Ratha Korn Vilaichone, Thawee Ratanachu ek, Pornpen Gamnarai, Phawinee Subsomwong, Tomahisa Uchida, Yoshio Yamaoka, Varocha Mahachai
Background and aims: Helicobacter pylori (H. pylori) infections, associated with fatal GI diseases such as gastric cancer and MALT lymphoma, remain a major health problem in ASEAN countries. The Golden triangle has long been known as one of Asia’s main opium-producing areas. There have been no prior studies of H. pylori infection in this area. The major objectives of this project were therefore to establish prevalence, antibiotic resistance patterns and associated predictive in the Golden triangle. Methods: We recruited dyspeptic patients in Chiang khong and Chiang saen districts, Chiangrai province of Thailand...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345426/prevalence-and-risk-factors-of-multi-drug-resistant-tuberculosis-in-dalian-china
#3
Xin-Tong Lv, Xi-Wei Lu, Xiao-Yan Shi, Ling Zhou
Objectives To investigate the prevalence and risk factors associated with multi-drug resistant tuberculosis (MDR-TB) in Dalian, China. Methods This was a retrospective review of data from patients attending a TB clinic in Dalian, China between 2012 and 2015. Demographic and drug susceptibility data were retrieved from TB treatment cards. Univariate logistic analysis was used to assess the association between risk factors and MDR-TB. Results Among the 3552 patients who were smear positive for Mycobacterium tuberculosis (MTB), 2918 (82...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28345184/spatial-molecular-epidemiology-of-carbapenem-resistant-and-new-delhi-metallo-beta-lactamase-blandm-producing-escherichia-coli-strains-from-farmed-piglets-of-india
#4
B S Pruthvishree, O R Vinodh Kumar, D K Sinha, Y P S Malik, Z Dubal, P A Desingu, M Shivakumar, Narayanan Krishnaswamy, B R Singh
AIM: A cross-sectional study was conducted in ten government organized pig farms between 2014 and 2016 representing seven states of India to understand the epidemiology of carbapenem resistance in Escherichia coli isolates. METHODS AND RESULTS: In this study, 673 fecal samples both from non- diarhhoeic (n=501) and diarrhoeic (n=172) piglets were processed for isolation of carbapenem resistant E. coli. Wherein, 112 confirmed E. coli isolates were further subjected for genotypic confirmation of carbapenem resistance and virulence factors...
March 27, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28344395/characterization-of-salmonella-gallinarum-from-an-outbreak-in-raigarh-chhattisgarh
#5
Chandrahas Sannat, Anil Patyal, Nidhi Rawat, R C Ghosh, D K Jolhe, R K Shende, S D Hirpurkar, Sanjay Shakya
AIM: The present investigation was conducted to isolate and characterize Salmonella Gallinarum from an outbreak of fowl typhoid in layer birds. MATERIALS AND METHODS: Clinically ill and dead layer birds from an outbreak were investigated. History, clinical signs, and postmortem lesions were suggestive of fowl typhoid. Postmortem samples including heart blood, intestinal contents, pieces of ovary, and liver were collected and processed immediately for bacterial culture, serotyping and antibiotic sensitivity tests...
February 2017: Veterinary World
https://www.readbyqxmd.com/read/28344162/identification-of-genetic-markers-of-resistance-to-echinocandins-azoles-and-5-fluorocytosine-in-candida-glabrata-by-next-generation-sequencing-a-feasibility-study
#6
Chayanika Biswas, Sharon C-A Chen, Catriona Halliday, Karina Kennedy, E Geoffrey Playford, Deborah J Marriott, Monica A Slavin, Tania C Sorrell, Vitali Sintchenko
OBJECTIVES: Multi-antifungal drug resistance in Candida glabrata is increasing. We examined the feasibility of next generation sequencing (NGS) to investigate the presence of antifungal drug resistance markers in C. glabrata. METHODS: The antifungal susceptibility of 12 clinical isolates and one ATCC strain of C. glabrata was determined using the Sensititre YeastOne® YO10 assay. These included three isolate pairs where the second isolate of each pair had developed a rise in drug MICs...
March 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28342672/an-in-vitro-larval-migration-assay-for-assessing-anthelmintic-activity-of-different-drug-classes-against-ascaris-suum
#7
Jianguo Zhao, Andrew R Williams, Tina Vicky Alstrup Hansen, Stig M Thamsborg, Jianping Cai, Shuaibao Song, Gang Chen, Ming Kang, Zhuangzhi Zhang, Qun Liu, Qian Han
In vitro methods have been developed for the detection of anthelmintic resistance in a range of nematode species. However, the life cycle of Ascaris suum renders the commonly used egg hatch assay and larval development assay unusable. In this study we developed a combined multi-well culture and agar gel larval migration assay to test the effect of benzimidazole and tetrahydropyrimidin/imidazothiazole anthelmintics against nine isolates of A. suum collected from locations in China and Denmark. Drugs tested were thiabendazole, fenbendazole, mebendazole, levamisole, and pyrantel...
March 18, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28342461/-the-infection-risk-assessment-visit-in-haemodialysis-a-new-tool
#8
REVIEW
Élisabeth Laprugne-Garcia, Sophie Gardes
Haemodialysis is a speciality with a high risk of infection, due in part to the frailty of the patients (immunosuppressed, high prevalence of carriers of multi-drug resistant bacteria), as well as to the invasive procedures carried out (inserting central venous catheters, using these catheters and arteriovenous fistulas). The infection risk assessment visit in haemodialysis is a tool which contributes to the safety of care.
March 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28339722/prevalence-and-drug-resistance-of-avian-eimeria-species-in-broiler-chicken-farms-of-zhejiang-province-china
#9
L-H Lan, B-B Sun, B-X-Z Zuo, X-Q Chen, A-F Du
In this study, coccidia were isolated and identified from 5 main poultry farms located in Zhejiang province, eastern China. The overall prevalence of Eimeria spp. was 30.7% (95 of 310). Five common species were observed: E. tenella, E. acervulina, E. maxima, E. necatrix, and E. mitis. Two isolates (HZ and QZ) were tested for sensitivity to 8 anticoccidial drugs using 4 indexes including anticoccidial index (ACI), percent of optimum anticoccidial activity (POAA), reduction of lesion scores (RLS), and relative oocyst production (ROP): sulfachloropyrazine, toltrazuril, diclazuril, sulfamonomethoxine/trimethoprim, and amprolium; sulfaquinoxaline/sulfadimethoxine, nicarbazin, and halofuginone...
February 22, 2017: Poultry Science
https://www.readbyqxmd.com/read/28337489/antibiotic-resistance-profiling-and-microbiota-of-the-upper-respiratory-tract-of-apparently-healthy-dogs-in-ibadan-south-west-nigeria
#10
Oluwafemi Babatunde Daodu, Elizabeth Adesola Amosun, Daniel Oladimeji Oluwayelu
BACKGROUND: Rearing of dogs and other pets has become increasingly popular in modern society. Bacterial flora resides within the nasal and oral cavities of dogs and when chanced, can be pathogenic. Certain similarities between humans and dogs portends dangerous behavioral habits that could lead to zoonotic disease transmission. This study was aimed at isolation, identification and antibiotic profiling of bacteria from nasal swabs of apparently healthy dogs. The zoonotic risk was also considered...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28336470/bioassay-guided-isolation-of-active-principles-from-nigerian-medicinal-plants-identifies-new-trypanocides-with-low-toxicity-and-no-cross-resistance-to-diamidines-and-arsenicals
#11
Godwin Unekwuojo Ebiloma, John Ogbaji Igoli, Evangelos Katsoulis, Anne-Marie Donachie, Anthonius Eze, Alexander Ian Gray, Harry P de Koning
ETHNOPHARMACOLOGICAL RELEVANCE: Leaves from the plant species studied herein are traditionally used in northern Nigeria against various protozoan infections. However, none of these herbal preparations have been standardized, nor have their toxicity to mammalian cells been investigated. In search of improved and non-toxic active antiprotozoal principles that are not cross-resistant with current anti-parasitics, we here report the results of the in vitro screening of extracts from seven selected medicinal plant species (Centrosema pubescens, Moringa oleifera, Tridax procumbens, Polyalthia longifolia, Newbouldia laevis, Eucalyptus maculate, Jathropha tanjorensis), used traditionally to treat kinetoplastid infections in Nigeria, and the isolation of their bioactive principles...
March 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28335655/the-therapeutic-potential-of-targeting-abc-transporters-to-combat-multi-drug-resistance
#12
Piyush Bugde, Riya Biswas, Fabrice Merien, Jun Lu, Dong-Xu Liu, Mingwei Chen, Shufeng Zhou, Yan Li
Most disseminated cancers remain fatal despite the availability of a variety of conventional and novel treatments including surgery, chemotherapy, radiotherapy, immunotherapy, and biologically targeted therapy. A major factor responsible for the failure of chemotherapy in the treatment of cancer is the development of multidrug resistance (MDR). The overexpression of various ABC transporters in cancer cells can efficiently remove the anticancer drug from the cell, thus causing the drug to lose its effect. Areas covered: In this review, we summarised the ongoing research related to the mechanism, function, and regulation of ABC transporters...
March 24, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28335544/combination-effect-of-antituberculosis-drugs-and-ethanolic-extract-of-selected-medicinal-plants-against-multi-drug-resistant-mycobacterium-tuberculosis-isolates
#13
Prabasiwi Nur Fauziyah, Elin Yulinah Sukandar, Dhyan Kusuma Ayuningtyas
Adverse drug reaction and resistance to antituberculosis drugs remain the causes of tuberculosis therapeutic failure. This research aimed to find the combination effect of standard antituberculosis drugs with Hibiscus sabdariffa L., Kaempferia galanga L., and Piper crocatum N.E. Br against multi-drug resistant (MDR) Mycobacterium tuberculosis isolates. Two MDR strains (i.e., isoniazid/ethambutol resistant and rifampicin/streptomycin resistant) of M. tuberculosis were inoculated in Löwenstein-Jensen medium containing a combination of standard antituberculosis drugs and ethanolic extracts of H...
March 20, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28334049/mmp1-expression-is-activated-by-slug-and-enhances-multi-drug-resistance-mdr-in-breast-cancer
#14
Ching-Ju Shen, Yu-Ling Kuo, Chien-Chung Chen, Ming-Jenn Chen, Ya-Min Cheng
High matrix metalloproteinase 1 (MMP1) expression is associated with enhanced breast cancer growth and metastasis and also might predict poor prognosis. In this study, we further investigated the functional role of MMP1 and how it is upregulated in multi-drug resistant (MDR) breast cancer cells. By retrieving microarray data in GEO datasets and the survival data in the Kaplan Meier plotter, we observed that MMP1 is significantly upregulated in MCF-7/ADR cells compared to the parental MCF-7 cells, while high MMP1 expression is associated with worse overall survival (OS) and recurrence free survival (RFS) in breast cancer patients after systematic therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28334005/multi-scale-model-of-drug-induced-adaptive-resistance-of-gram-negative-bacteria-to-polymyxin-b
#15
Wojciech Krzyzanski, Gauri G Rao
The purpose of this report is to apply multi-scale modeling using the theory of physiologically structured populations (PSP) to develop a mathematical model for antimicrobial resistance based on a heterogeneous distribution of receptors and affinities among bacterial cells. The theory has been tested on data obtained from an in vitro static time-kill infection model analyzing the pharmacodynamics of polymyxin B against Gram-negative bacteria. The drug binding parameter KD (dissociation equilibrium constant) is assumed to vary between the bacterial cells...
2017: PloS One
https://www.readbyqxmd.com/read/28331426/environmental-distribution-and-drug-susceptibility-of-achromobacter-xylosoxidans-isolated-from-outdoor-and-indoor-environments
#16
Sachiko Nakamoto, Misaki Sakamoto, Kana Sugimura, Yuki Honmura, Yuki Yamamoto, Natsumi Goda, Hiroo Tamaki, Naoto Burioka
Achromobacter xylosoxidans is an environmental bacterium with multi-drug resistance. We isolated Achromobacter xylosoxidans and investigated its susceptibility to 13 drugs. Seventy-eight water samples were collected from rivers and ponds, and 11 samples were swabbed from residential sinks and baths. Nine strains of Achromobacter xylosoxidans were isolated from the 89 samples. Five strains, including 2 that were sampled from residential homes, showed high resistance to multiple aminoglycosides. This indicated that Achromobacter xylosoxidans is widely distributed in various outdoor and indoor environments...
March 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28330178/emergence-of-mixed-infection-of-beijing-non-beijing-strains-among-multi-drug-resistant-mycobacterium-tuberculosis-in-pakistan
#17
Samar Mustafa, Hasnain Javed, Jawairia Hashmi, Nazia Jamil, Zarfishan Tahir, Abdul Majeed Akhtar
Tuberculosis (TB) remains as one of the deadliest diseases after HIV globally with 95 % of deaths confined to low-and-middle income countries. Pakistan is fifth among the 22 high-burden TB countries with the incidence rate of 230/100,000 persons, however, studies related to prevalent Mycobacterium tuberculosis strains and their spread, drug resistance pattern and evolutionary genetics are inadequate. The present study was undertaken to highlight the circulation of M. tuberculosis strains causing drug resistant TB in our community by targeting the molecular marker IS6110 and then characterization of these strains as Beijing and Non-Beijing genotypes...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28328161/synthesis-in-vitro-evaluation-and-68-ga-radiolabeling-of-cdp1-towards-pet-ct-imaging-of-bacterial-infection
#18
Jyotibon Dutta, Sooraj Baijnath, Anou M Somboro, Savania Nagiah, Fernando Albericio, Beatriz G de la Torre, Biljana Marjanovic-Painter, Jan Rijn Zeevaart, Mike Sathekge, Hendrik G Kruger, Anil Chuturgoon, Tricia Naicker, Thomas Ebenhan, Thavendran Govender
Bacterial infections are a major concern in the human health sector due to poor diagnosis and development of multi drug resistant strains. PET/CT provides a means for the noninvasive detection and localization of the infectious foci; however, the radiotracers available are either cumbersome to prepare or their exact contribution towards the imaging is not yet established. Human antimicrobial peptides are of interest for development as PET radiotracers as they are an integral component of the immune system, non-immunogenic towards the recipient and show selectivity towards pathogens such as bacteria...
March 22, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28327183/modeling-multi-mutation-and-drug-resistance-analysis-of-some-case-studies
#19
Mitra Shojania Feizabadi
BACKGROUND: Drug-induced resistance is one the major obstacles that may lead to therapeutic failure during cancer treatment. Different genetic alterations occur when tumor cells divide. Among new generations of tumor cells, some may express intrinsic resistance to a specific chemotherapeutic agent. Also, some tumor cells may carry a gene that can develop resistance induced by the therapeutic drug. The methods by which the therapeutic approaches need to be revised in the occurrence of drug induced resistance is still being explored...
March 21, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/28327117/preliminary-evaluation-of-anti-tuberculosis-potential-of-siderophores-against-drug-resistant-mycobacterium-tuberculosis-by-mycobacteria-growth-indicator-tube-drug-sensitivity-test
#20
Karuna Gokarn, Ramprasad B Pal
BACKGROUND: Alternative treatment strategies have become essential in overcoming the problem of drug-resistant Mycobacterium tuberculosis (Mtb). In this preliminary in vitro study, the anti-tuberculosis (anti-TB) activity of exogenous iron chelators (xenosiderophores) such as Exochelin-MS (Exo-MS) and Deferoxamine-B (DFO-B) was evaluated against ten multi-drug-resistant (MDR) and seven pyrazinamide-resistant (PZA (R) ) Mtb isolates. METHODS: Mycobacteria Growth Indicator Tube-Drug Susceptibility Test was used to assess the anti-TB effect of Exo-MS or DFO-B individually and their combinations with isoniazid (INH), rifampicin (RIF) and pyrazinamide (PZA)...
March 21, 2017: BMC Complementary and Alternative Medicine
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