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Multi drug resistance microorganism

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https://www.readbyqxmd.com/read/29151063/predation-among-microorganisms-a-huge-potential-of-interspecies-dependencies
#1
Justyna Kowalska, Marcin Włodarczyk
There are many interactions between species (including bacteria) in the environment. One of them is predation, which always leads to the death of a prey. Described in this review Bdellovibrio bacteriovorus (Deltaproteobacteria) and Micavibrio aeruginosavorus (Alfaproteobacteria) are uniflagellate, rod shaped and curved obligate predators of Gram-negative bacteria. Both species belong to the group of BALOs (Bdellovibrio and like organisms). B. bacteriovorus use periplasmic predatory strategy and M. aeruginosavorus are epibiotic hunters...
November 3, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29150378/enhanced-antibacterial-effects-of-green-synthesized-zno-nps-using-aristolochia-indica-against-multi-drug-resistant-bacterial-pathogens-from-diabetic-foot-ulcer
#2
Katherin Steffy, G Shanthi, Anson S Maroky, S Selvakumar
BACKGROUND: Increased incidence of Multi-drug resistance in microorganisms has become the greatest challenge in the treatment of Diabetic Foot Ulcer (DFU) and urges the need of a new antimicrobial agent. In this study, we determined the bactericidal effects of ZnO nanoparticles (ZnO NPs) green synthesized from Aristolochia indica against Multi-drug Resistant Organisms (MDROs) isolated from pus samples of DFU patients attending in a tertiary care hospital in South India. METHODS: ZnO NPs were characterized by UV-vis-DRS spectroscopy, Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM) and for its zeta potential value...
November 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29107747/vanillin-selectively-modulates-the-action-of-antibiotics-against-resistant-bacteria
#3
Camila Fonseca Bezerra, Cicera Janaine Camilo, Maria Karollyna do Nascimento Silva, Thiago Sampaio de Freitas, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho
The treatment of infections caused by microorganisms that are resistant to antibiotics represent one of the main challenges of medicine today, especially due to the inefficacy of long-term drug therapy. In the search for new alternatives to treat these infections, many researchers have been looking for new substances derived from natural products to replace, or be used in combination with conventional antibiotics. Vanillin is a phenolic compound whose antimicrobial activity has been used in the elimination of pathogens present in fruits and vegetables...
October 28, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29071232/vancomycin-capped-with-silver-nanoparticles-as-an-antibacterial-agent-against-multi-drug-resistance-bacteria
#4
Mahsa Esmaeillou, Gholamreza Zarrini, Mohammad Ahangarzadeh Rezaee, Javid Shahbazi Mojarrad, Ali Bahadori
Purpose: Many antimicrobial medications are available to combat infections. However, the indiscriminate use of antibiotics has produced antibiotic resistance in the case of many bacterial pathogens. This study focuses on the development of nanoparticles (NPs) that enhance the in vitro antibiotic activity of vancomycin against multi-drug resistant (MDR) organisms. Methods: Spherical shaped thioglycolic acid-stabilized silver nanoparticles (TGA-AgNPs) were prepared by using a simple chemical reduction method...
September 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29065880/identification-and-utilization-of-two-important-transporters-sgvt1-and-sgvt2-for-griseoviridin-and-viridogrisein-biosynthesis-in-streptomyces-griseoviridis
#5
Yunchang Xie, Junying Ma, Xiangjing Qin, Qinglian Li, Jianhua Ju
BACKGROUND: Griseoviridin (GV) and viridogrisein (VG, also referred as etamycin), both biosynthesized by a distinct 105 kb biosynthetic gene cluster (BGC) in Streptomyces griseoviridis NRRL 2427, are a pair of synergistic streptogramin antibiotics and very important in treating infections of many multi-drug resistant microorganisms. Three transporter genes, sgvT1-T3 have been discovered within the 105 kb GV/VG BGC, but the function of these efflux transporters have not been identified...
October 25, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29063446/extensive-colonization-with-carbapenemase-producing-microorganisms-in-romanian-burn-patients-infectious-consequences-from-the-colectiv-fire-disaster
#6
L E Pirii, A W Friedrich, J W A Rossen, W Vogels, G I J M Beerthuizen, M K Nieuwenhuis, A M D Kooistra-Smid, E Bathoorn
Health care of severe burn patients is highly specialized and may require international patient transfer. Burn patients have an increased risk of developing infections. Patients that have been hospitalized in countries where carbapenemase-producing microorganisms (CPMO) are endemic may develop infections that are difficult to treat. In addition, there is a risk on outbreaks with CPMOs in burn centers. This study underlines that burn patients may extensively be colonized with CPMOs, and it provides best practice recommendations regarding clinical microbiology and infection control...
October 23, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29018426/transfer-and-persistence-of-a-multi-drug-resistance-plasmid-in-situ-of-the-infant-gut-microbiota-in-the-absence-of-antibiotic-treatment
#7
Heidi Gumpert, Jessica Z Kubicek-Sutherland, Andreas Porse, Nahid Karami, Christian Munck, Marius Linkevicius, Ingegerd Adlerberth, Agnes E Wold, Dan I Andersson, Morten O A Sommer
The microbial ecosystem residing in the human gut is believed to play an important role in horizontal exchange of virulence and antibiotic resistance genes that threatens human health. While the diversity of gut-microorganisms and their genetic content has been studied extensively, high-resolution insight into the plasticity, and selective forces shaping individual genomes is scarce. In a longitudinal study, we followed the dynamics of co-existing Escherichia coli lineages in an infant not receiving antibiotics...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29016580/surgical-site-infections-and-antimicrobial-resistance-pattern
#8
Raskin Chaudhary, Shrawan Kumar Thapa, Jid Chani Rana, Pradeep Kumar Shah
BACKGROUND: Post-operative surgical site infections (SSIs) are among the leading cause of morbidity and increased medical expense. The aim of this study is to isolate identify and study antimicrobial susceptibility pattern of microorganism from surgical wound of admitted patients. METHODS: This retrospective study was carried at the Microbiology Laboratory of Bharatpur hospital, Nepal, from May 2015 to October 2015. The pus samples were cultured and antibiotic susceptibility determined in vitro by Kirby Bauer's disc diffusion method following clinical and Laboratory Standards Institute (CLSI) 2014 recommendation...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28968210/plant-derived-antimicrobial-peptide-ib-amp1-as-a-potential-alternative-drug-candidate-for-staphylococcus-aureus-toxins
#9
S Ojha, S Deep, S Kundu
Due to an increase in the occurrence of multi drug resistant microorganisms a need for the development of alternative drugs comes in light. This alternative drug should be such that the microorganisms should not be able to develop resistance against them easily. Antimicrobial peptides are the most potential candidates to be developed as alternative drug. In the present study the three toxins ETA, ETB and PVL of Staphylococcus aureus were docked with four antimicrobial peptides, Ib-AMP1, JCPep7, Snakin2, Sesquin, derived from plants...
July 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28964884/a-cross-sectional-point-prevalence-survey-to-study-the-environmental-contamination-of-nosocomial-pathogens-in-intensive-care-units-under-real-life-conditions
#10
I Wille, A Mayr, P Kreidl, C Brühwasser, G Hinterberger, A Fritz, W Posch, S Fuchs, A Obwegeser, D Orth-Höller, C Lass-Flörl
BACKGROUND: In intensive care units (ICUs) inanimate surfaces and equipment may be contaminated by nosocomial pathogens, including multi-drug resistant microorganisms. AIMS: To assess the degree of patients' close and distant environmental contamination including healthcare workers' (HCWs) hands with nosocomial pathogens under real life situations and to investigate potential transmission events. METHODS: For the course of three weeks agar contact samples were taken close and distant to the patient area and from HCWs' hands in eight ICUs of a tertiary care hospital in Innsbruck, Austria...
September 27, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28956374/-progress-in-antimicrobial-substances-of-endophytes
#11
Jingyu Huang, Chujun Zhang, Yulong Yao, Xu Gao, Ziqi Hou, Lu Zhang, Ou Li
Isolation and characterization of metabolites produced by endophytes are significant ways to search for novel natural active substances, proving that the endophytes are the unique resources of newer and more effective compounds. Many new compounds with antimicrobial activity from different endophytes have been isolated so far. These new compounds provide alternatives to fight against multi-drug resistance of microorganisms. This review outlined the major achievements and latest developments of endophytes, including the diversity of endophytes and antimicrobial activity of endophytes, as well as its development in China...
February 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28955612/endophytic-bacteria-a-new-source-of-bioactive-compounds
#12
REVIEW
Monika Singh, Ajay Kumar, Ritu Singh, Kapil Deo Pandey
In recent years, bioactive compounds are in high demand in the pharmaceuticals and naturopathy, due to their health benefits to human and plants. Microorganisms synthesize these compounds and some enzymes either alone or in association with plants. Microbes residing inside the plant tissues, known as endophytes, also produce an array of these compounds. Endophytic actinomycetes act as a promising resource of biotechnologically valuable bioactive compounds and secondary metabolites. Endophytic Streptomyces sp...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28948807/fatal-progression-of-multifocal-infection-of-aspergillus-sp-and-multi-resistant-pseudomonas-aeruginosa-in-a-patient-with-toxic-epidermal-necrolysis-and-renal-cancer
#13
B Lipový, H Řihová, M Hanslianová, Z Chaloupková, M Hromaníková, Z Pavlovský, T Kempný, I Suchánek, P Brychta
Toxic epidermal necrolysis is an autoimmune disease expressed predominantly on the skin and mucous membranes. It is a serious bullous disease manifesting itself by induction of apoptosis in the dermo-epidermal junction. In most cases,it is attributable to the use of some drug. The basic approach to stopping progression of the disease is immunosuppression. Unfortunately, patients with such extensive loss of epidermis and defective mucosa are confronted by a variety of opportunistic, potentially pathogenic microorganisms...
2017: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/28882325/antimicrobial-stewardship-programme-in-critical-care-medicine-a-prospective-interventional-study
#14
J Ruiz, P Ramirez, M Gordon, E Villarreal, J Frasquet, J L Poveda-Andres, M Salavert-Lletí, A Catellanos
OBJECTIVE: Hospital antimicrobial stewardship programmes have achieved savings and a more rational use of antimicrobial treatments in general wards. The purpose of this report is to evaluate the experience of an antimicrobial stewardship programme in an intensive care unit (ICU). DESIGN: Prospective interventional, before-and-after study. SCOPE: 24-bed medical ICU in a tertiary hospital. INTERVENTION: Prospective audit and feedback antimicrobial stewardship programme...
September 4, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28869082/development-of-botanicals-to-combat-antibiotic-resistance
#15
REVIEW
Pooja D Gupta, Tannaz J Birdi
The discovery of antibiotics in the previous century lead to reduction in mortality and morbidity due to infectious diseases but their inappropriate and irrational use has resulted in emergence of resistant microbial populations. Alteration of target sites, active efflux of drugs and enzymatic degradations are the strategies employed by the pathogenic bacteria to develop intrinsic resistance to antibiotics. This has led to an increased interest in medicinal plants since 25-50% of current pharmaceuticals are plant derived...
August 30, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28845129/sepsis-epidemiology-and-outcome-in-the-paediatric-intensive-care-unit-of-vilnius-university-children-s-hospital
#16
Odeta Bobelytė, Ieva Gailiūtė, Vytautas Zubka, Virginija Žilinskaitė
Research was carried out at the paediatric intensive care unit (paediatric ICU) of the Children's Hospital, affiliate of Vilnius University Hospital Santariškių klinikos. BACKGROUND: Being the most common cause of children's death, sepsis is a challenge for most physicians. In order to improve the outcomes, it is important to know the aetiology and peculiarities of sepsis in a particular region and hospital. The aim of this study was to analyse the outcomes of sepsis in a paediatric intensive care unit and their relation with patients' characteristics and causative microorganisms...
2017: Acta medica Lituanica
https://www.readbyqxmd.com/read/28756167/a-multimodal-infection-control-concept-in-a-burn-intensive-care-unit-lessons-learnt-from-a-meticillin-resistant-staphylococcus-aureus-outbreak
#17
C Baier, R Ipaktchi, E Ebadi, A Limbourg, T R Mett, P M Vogt, F-C Bange
BACKGROUND: Meticillin-resistant Staphylococcus aureus (MRSA) is a frequently encountered pathogen in burn units. Burn patients are especially susceptible to MRSA acquisition and MRSA spread may cause outbreaks in burn units. AIM: To report the characteristics and successful control of an MRSA outbreak and to demonstrate a multimodal infection control concept. METHODS: In addition to a pre-existing infection control concept, several control measures were implemented including weekly prevalence screenings for MRSA, reinforcement of disinfection, restriction of admissions, and short-term unit closure...
July 26, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28706515/more-pathogenicity-or-just-more-pathogens-on-the-interpretation-problem-of-multiple-pathogen-detections-with-diagnostic-multiplex-assays
#18
REVIEW
Andreas E Zautner, Uwe Groß, Matthias F Emele, Ralf M Hagen, Hagen Frickmann
Modern molecular diagnostic approaches in the diagnostic microbiological laboratory like real-time quantitative polymerase chain reaction (qPCR) have led to a considerable increase of diagnostic sensitivity. They usually outperform the diagnostic sensitivity of culture-based approaches. Culture-based diagnostics were found to be insufficiently sensitive for the assessment of the composition of biofilms in chronic wounds and poorly standardized for screenings for enteric colonization with multi-drug resistant bacteria...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28669833/pathobiology-of-lomentospora-prolificans-could-this-species-serve-as-a-model-of-primary-antifungal-resistance
#19
Aize Pellon, Andoni Ramirez-Garcia, Idoia Buldain, Aitziber Antoran, Leire Martin-Souto, Aitor Rementeria, Fernando L Hernando
The number of fungal isolates resistant to antifungal drugs has increased dramatically over the last few years and has become an important concern for clinicians. Among these isolates, fungi showing multidrug resistance are especially worrying because of the difficulties associated with their treatment. These factors hamper the successful recovery of patients and drastically raise mortality rates. Therefore, since it is well known that antifungal resistance is multifactorial and several mechanisms in different fungi have been described, there is a need to study these processes in depth...
June 29, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28650661/triaryl-benzimidazoles-as-a-new-class-of-antibacterial-agents-against-resistant-pathogenic-microorganisms
#20
Pietro Picconi, Charlotte Hind, Shirin Jamshidi, Kazi Nahar, Melanie Clifford, Matthew E Wand, J Mark Sutton, Khondaker Miraz Rahman
A new class of nontoxic triaryl benzimidazole compounds, derived from existing classes of DNA minor groove binders, were designed, synthesized, and evaluated for their antibacterial activity against multidrug resistant (MDR) Gram-positive and Gram-negative species. Molecular modeling experiments suggest that the newly synthesized class cannot be accommodated within the minor groove of DNA due to a change in the shape of the molecules. Compounds 8, 13, and 14 were found to be the most active of the series, with MICs in the range of 0...
July 27, 2017: Journal of Medicinal Chemistry
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