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Multi drug resistance microorganism

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https://www.readbyqxmd.com/read/29751552/molecular-docking-evaluation-of-e-5-arylidene-2-thioxothiazolidin-4-one-derivatives-as-selective-bacterial-adenylate-kinase-inhibitors
#1
Mihaela Ileana Ionescu, Ovidiu Oniga
Multi-drug resistant microorganism infections with emerging problems that require not only a prevention strategy, but also the development of new inhibitory compounds. Six previously synthesized 5-arylidene-2-thioxothiazolidin-4-one derivatives 1a ⁻ f , were screened for inhibitory activity on adenylate kinases of different origins by molecular docking. The compounds 1c and 1d were the most efficient inhibitors of bacterial and some archean adenylate kinases. Hydrogen bond interactions were observed with the residues belonging to the ATP binding site...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29702423/microbial-interactions-trigger-the-production-of-antibiotics
#2
REVIEW
Tina Netzker, Michal Flak, Mario Kc Krespach, Maria C Stroe, Jakob Weber, Volker Schroeckh, Axel A Brakhage
Since the discovery of penicillin, antibiotics have been instrumental in treating infectious diseases. However, emerging antibiotic multi-resistance coinciding with a nearly exhausted drug pipeline is a major concern for the future of the therapy of infections. A novel approach for the discovery of antibiotics relies on the analysis of microbial consortia in their ecological context, taking into account the potential natural role of antibiotics. Co-cultivations of microorganisms have been successfully applied for the isolation of unknown secondary metabolites including antibiotics, and, thus, open new avenues to the production of bioactive compounds while at the same time providing insight into the natural function of the produced molecules and the regulation of their formation...
April 24, 2018: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29700554/platelet-rich-plasma-as-an-additional-therapeutic-option-for-infected-wounds-with-multi-drug-resistant-bacteria-in-vitro-antibacterial-activity-study
#3
Rıza Aytaç Çetinkaya, Ercan Yenilmez, Patrizio Petrone, Soner Yılmaz, Bayhan Bektöre, Berksan Şimsek, Tuğba Kula Atik, Mustafa Özyurt, Aytekin Ünlü
PURPOSE: Infected wounds, such as diabetic foot infections, are mostly polymicrobial and microorganisms have high resistance rates to antimicrobials. Infected wounds in diabetic patients have high cost, morbidity, and mortality rates. Based on these facts, there is a need for supportive localized treatment options such as platelet-rich plasma (PRP) implementations. Demonstrating the in vitro antimicrobial effect, our aim was to lead up to clinical trials of localized PRP implementations in infected wounds such as diabetic foot infections...
April 26, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29693574/liver-transplantation-and-gut-microbiota-profiling-in-a-child-colonized-by-a-multi-drug-resistant-klebsiella-pneumoniae-a-new-approach-to-move-from-antibiotic-to-eubiotic-control-of-microbial-resistance
#4
Federica Del Chierico, Sabrina Cardile, Andrea Pietrobattista, Daniela Liccardo, Alessandra Russo, Manila Candusso, Maria Sole Basso, Chiara Grimaldi, Laura Pansani, Paola Bernaschi, Giuliano Torre, Lorenza Putignani
The increase of microorganisms multi-drug resistant (MDR) to antibiotics (ATBs) is becoming a global emergency, especially in frail subjects. In chronic liver disease (LD) with indications for liver transplantation (LT), MDR colonization can significantly affect the LT outcome. However, no clear guidelines for microbial management are available. A novel approach toward MDR-colonized patients undergoing LT was developed at our Center refraining from ATBs use during the transplant waiting list, and use of an intensive perioperative prophylaxis cycle...
April 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29618862/acetic-acid-dressings-finding-the-holy-grail-for-infected-wound-management
#5
Kapil S Agrawal, Anup Vidyadhar Sarda, Raghav Shrotriya, Manoj Bachhav, Vinita Puri, Gita Nataraj
Background: Wounds have since long, contributed majorly to the health-care burden. Infected long-standing non-healing wounds place many demands on the treating surgeon and are devastating for the patients physically, nutritionally, vocationally, financially, psychologically and socially. Acetic acid has long been included among agents used in the treatment of infected wounds. In this study, we have evaluated the use of acetic acid for topical application in the treatment of infected wounds...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29618431/investigation-of-staphylococcus-aureus-prevailing-in-the-environment-of-khyber-teaching-hospital-peshawar-pakistan
#6
Farmanullah Khan, Bashir Ahmad, Jawad Ahmed, Han Sang Yoo, Shumaila Bashir
The hospital environment plays an important role in the spread of microorganisms, including multi drug resistant (MDR) strains. Patients can acquire Methicillin-Resistant Staphylococcus aureus (MRSA) which can reside in the clinical setup that are not cleaned and can spread through air droplets, bed clothing, and healthcare workers. The purpose of this study was to investigate the prevalence of S. aureus in the Khyber Teaching Hospital (KTH). A total of 200 samples were collected from the floor, walls, air and inanimate objects in different wards of the KTH, during May 2012 to September 2012...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29508365/introducing-an-antibiotic-stewardship-program-in-a-pediatric-center-in-china
#7
Zhi-Gang Zhang, Fei Chen, Jian-Zhong Chen
BACKGROUND: This study aimed to investigate the effect of antibiotic stewardship programs (ASP) on reducing antimicrobial resistance rate, antibiotics consumption and multi-drug resistance bacterial infections in the pediatric patients. METHODS: This study was carried out in the Pediatric Center of a tertiary hospital of Shandong Province, China. The study duration was separated into two periods according to introduction of ASP (began from April 2011). Before intervention: from April 2009 to March 2011; after intervention: from April 2012 to March 2014...
March 5, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29460560/-isolation-precautions-in-multi-drug-resistent-infections-and-nursing-workload-in-a-general-intensive-care-unit
#8
Stefano Elli, Luigi Cannizzo, Giuseppe Foti, Roberto Fumagalli, Alberto Lucchini
BACKGROUND: Critically ill patients in ICU are exposed to high risk of hospital acquired infections. In recent years, the multi drug resistant microorganisms (MDR) represent the most worrying epidemiological problem. AIM: The aim of this study is to evaluate the relationship between isolation precautions and nursing workload. METHODS: We studied patients who had an infection by MDR, subject to isolation precautions, and measured their NAS score during stay in ICU...
October 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29459597/prevalence-of-metallo-%C3%AE-lactamase-producing-non-fermentative-pseudomonas-species-from-clinical-isolates-in-dhaka-bangladesh
#9
M N Islam, D Ahmed, M A Hossain, C R Ahsan, M Yasmin
Antimicrobial drug resistance, a global concern, has been increasing unpredictably in microorganism causing human infections specially among Gram negative non-fermenting Pseudomonas spp. Carbapenems, a beta lactam antibiotics, are the most potent and effective drug usually kept reserved for treating the multi-drug resistant Psedomonas spp and other infections caused by organisms producing Extended Spectrum Beta Lactamase (ESBL) and AmpC. Clinical utility of carbapenem will reduce when resistant bacteria evolve due to production of carbapenem hydrolyzing Metallo-β-lactamase (MBL) which confers high-level resistance to all beta-lactam antibiotics except aztreonam...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29452993/an-in-vitro-evaluation-of-the-efficacy-of-tedizolid-implications-for-the-treatment-of-skin-and-soft-tissue-infections
#10
Pierre Delpech, Muna ALeryan, Brian Jones, Curtis Gemmell, Sue Lang
Skin and soft tissue infections (SSTI) are among the most commonly occurring infections and evidence suggests that these are increasing world-wide. The aetiology is diverse, but Staphylococcus aureus predominate and these are often resistant to antimicrobials that were previously effective. Tedizolid is a new oxazolidinone-class antibacterial indicated for the treatment of adults with SSTI caused by Gram-positive pathogens, including S. aureus. The aim of this study was to evaluate the in vitro efficacy of tedizolid in comparison to other clinically used antibacterials against antibiotic sensitive- and resistant-staphylococci, grown in planktonic cultures and as biofilms reflecting the growth of the microorganism during episodes of SSTI...
May 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29414740/airborne-microbial-communities-in-the-atmospheric-environment-of-urban-hospitals-in-china
#11
Xin-Lei Gao, Ming-Fei Shao, Qing Wang, Li-Tao Wang, Wen-Yan Fang, Feng Ouyang, Ji Li
Clinically relevant antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in bioaerosols have become a greater threat to public health. However, few reports have shown that ARB and ARGs were found in the atmosphere. High-throughput sequencing applied to environmental sciences has enhanced the exploration of microbial populations in atmospheric samples. Thus, five nosocomial bioaerosols were collected, and the dominant microbial and pathogenic microorganisms were identified by high-throughput sequencing in this study...
May 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29361414/the-evaluation-of-safety-and-efficacy-of-colistin-use-in-pediatric-intensive-care-unit-results-from-two-reference-hospitals-and-review-of-literature
#12
Zumrut Sahbudak Bal, Fulya Kamit Can, Pinar Yazici, Ayse Berna Anil, Muhterem Duyu, Dilek Yilmaz Ciftdogan, Ozkalay Nisel Yilmaz, Feriha Cilli, Bulent Karapinar
Colistin, an old cationic polypeptide antibiotic, have been reused due to rising incidence of infections caused by multi-drug resistant (MDR) Gram-negative microorganisms and the lack of new antibiotics. Therefore, we evaluated safety and efficacy of colistin in treatment of these infections. This study included 104 critically ill children with a median age of 55,9 months between January 2011 and January 2016. Nephrotoxicity occurred in 11 (10.5%) patients. Nephrotoxicity occurred between the third and seventh day of treatment in 63% of colistin induced nephrotoxicity episodes...
May 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29319784/the-effect-of-isabelin-a-sesquiterpene-lactone-from-ambrosia-artemisiifolia-on-soil-microorganisms-and-human-pathogens
#13
Francesco Molinaro, Olaf Tyc, Jules Beekwilder, Katarina Cankar, Cinzia Margherita Bertea, Michèle Negre, Paolina Garbeva
Ambrosia artemisiifolia L. (common ragweed) is an invasive weed, which is well known for the strong allergenic effect of its pollen as well as for its invasiveness and impact in crop fields (e.g. causing yield losses). This species produces a broad range of sesquiterpenoids. In recent years, new bioactive molecules have been discovered in this plant, e.g. isabelin, a sesquiterpene dilactone. The bioactivity of isabelin has been already demonstrated on allergy-related receptors and its inhibitory effect on seeds of various plant species...
February 1, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29190461/antimicrobial-photodynamic-therapy-single-walled-carbon-nanotube-swcnt-porphyrin-conjugate-for-visible-light-mediated-inactivation-of-staphylococcus-aureus
#14
Upasana Sah, Kajal Sharma, Nivedita Chaudhri, Muniappan Sankar, P Gopinath
Due to the excessive use of antibiotics over the years, the microorganisms have developed resistance to numerous drugs. The growth of multi-resistant organisms (MROs) heads due to the insufficient treatment with the currently available medications which present a great threat to the biotic component of the environment as well as to the food technology sectors. The goal of this research was to develop a nano-composite made up of single-walled carbon nanotubes (SWCNTs) and amine-functionalized porphyrin, which could further be used for the anti-microbial studies in presence of visible light showing photodynamic effect to inactivate cells...
February 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29151063/predation-among-microorganisms-a-huge-potential-of-interspecies-dependencies
#15
Justyna Kowalska, Marcin Włodarczyk
There are many interactions between species (including bacteria) in the environment. One of them is predation, which always leads to the death of a prey. Described in this review Bdellovibrio bacteriovorus (Deltaproteobacteria) and Micavibrio aeruginosavorus (Alfaproteobacteria) are uniflagellate, rod shaped and curved obligate predators of Gram-negative bacteria. Both species belong to the group of BALOs (Bdellovibrio and like organisms). B. bacteriovorus use periplasmic predatory strategy and M. aeruginosavorus are epibiotic hunters...
November 3, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29150378/enhanced-antibacterial-effects-of-green-synthesized-zno-nps-using-aristolochia-indica-against-multi-drug-resistant-bacterial-pathogens-from-diabetic-foot-ulcer
#16
Katherin Steffy, G Shanthi, Anson S Maroky, S Selvakumar
BACKGROUND: Increased incidence of Multi-drug resistance in microorganisms has become the greatest challenge in the treatment of Diabetic Foot Ulcer (DFU) and urges the need of a new antimicrobial agent. In this study, we determined the bactericidal effects of ZnO nanoparticles (ZnO NPs) green synthesized from Aristolochia indica against Multi-drug Resistant Organisms (MDROs) isolated from pus samples of DFU patients attending in a tertiary care hospital in South India. METHODS: ZnO NPs were characterized by UV-vis-DRS spectroscopy, Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM) and for its zeta potential value...
November 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29107747/vanillin-selectively-modulates-the-action-of-antibiotics-against-resistant-bacteria
#17
Camila Fonseca Bezerra, Cicera Janaine Camilo, Maria Karollyna do Nascimento Silva, Thiago Sampaio de Freitas, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho
The treatment of infections caused by microorganisms that are resistant to antibiotics represent one of the main challenges of medicine today, especially due to the inefficacy of long-term drug therapy. In the search for new alternatives to treat these infections, many researchers have been looking for new substances derived from natural products to replace, or be used in combination with conventional antibiotics. Vanillin is a phenolic compound whose antimicrobial activity has been used in the elimination of pathogens present in fruits and vegetables...
December 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29071232/vancomycin-capped-with-silver-nanoparticles-as-an-antibacterial-agent-against-multi-drug-resistance-bacteria
#18
Mahsa Esmaeillou, Gholamreza Zarrini, Mohammad Ahangarzadeh Rezaee, Javid Shahbazi Mojarrad, Ali Bahadori
Purpose: Many antimicrobial medications are available to combat infections. However, the indiscriminate use of antibiotics has produced antibiotic resistance in the case of many bacterial pathogens. This study focuses on the development of nanoparticles (NPs) that enhance the in vitro antibiotic activity of vancomycin against multi-drug resistant (MDR) organisms. Methods: Spherical shaped thioglycolic acid-stabilized silver nanoparticles (TGA-AgNPs) were prepared by using a simple chemical reduction method...
September 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29065880/identification-and-utilization-of-two-important-transporters-sgvt1-and-sgvt2-for-griseoviridin-and-viridogrisein-biosynthesis-in-streptomyces-griseoviridis
#19
Yunchang Xie, Junying Ma, Xiangjing Qin, Qinglian Li, Jianhua Ju
BACKGROUND: Griseoviridin (GV) and viridogrisein (VG, also referred as etamycin), both biosynthesized by a distinct 105 kb biosynthetic gene cluster (BGC) in Streptomyces griseoviridis NRRL 2427, are a pair of synergistic streptogramin antibiotics and very important in treating infections of many multi-drug resistant microorganisms. Three transporter genes, sgvT1-T3 have been discovered within the 105 kb GV/VG BGC, but the function of these efflux transporters have not been identified...
October 25, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29063446/extensive-colonization-with-carbapenemase-producing-microorganisms-in-romanian-burn-patients-infectious-consequences-from-the-colectiv-fire-disaster
#20
L E Pirii, A W Friedrich, J W A Rossen, W Vogels, G I J M Beerthuizen, M K Nieuwenhuis, A M D Kooistra-Smid, E Bathoorn
Health care of severe burn patients is highly specialized and may require international patient transfer. Burn patients have an increased risk of developing infections. Patients that have been hospitalized in countries where carbapenemase-producing microorganisms (CPMO) are endemic may develop infections that are difficult to treat. In addition, there is a risk on outbreaks with CPMOs in burn centers. This study underlines that burn patients may extensively be colonized with CPMOs, and it provides best practice recommendations regarding clinical microbiology and infection control...
January 2018: European Journal of Clinical Microbiology & Infectious Diseases
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