keyword
MENU ▼
Read by QxMD icon Read
search

frontal dementia

keyword
https://www.readbyqxmd.com/read/29682230/cognitive-functional-and-physical-activity-impairment-in-elderly-with-alzheimer-s-disease
#1
Renata Valle Pedroso, Danilla Icassatti Corazza, Carla Andreza de Almeida Andreatto, Thays Martins Vital da Silva, José Luiz Riani Costa, Ruth Ferreira Santos-Galduróz
Alzheimer's Disease (AD) is a progressive degenerative disorder that negatively affects quality of life of patients and family members. Objective: The aim of this study is to compare the cognition, level of physical activity and functioning of elderly individuals with mild AD and those without dementia. Methods: The study comprised 24 elderly with mild AD (mean age = 76.9 ± 5.3 years) and 30 elderly without dementia (mean age = 74.1 ± 5.6 years). The following instruments were applied to evaluate cognitive functions: MMSE; Frontal Assessment Battery; Clock Drawing Test; Corsi Blocks, and Verbal Paired Associates...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29659001/state-of-the-science-apathy-as-a-model-for-investigating-behavioral-and-psychological-symptoms-in-dementia
#2
Lauren Massimo, Helen C Kales, Ann Kolanowski
Apathy is one of the most common and pervasive of the behavioral and psychological symptoms of dementia (BPSDs). Apathy has profound consequences for morbidity, mortality, and caregiver burden. Treatment of apathy has been hindered because of poor understanding of the mechanisms underlying this heterogeneous syndrome. Research has demonstrated that apathy is associated with disruption of the frontal-striatal system in individuals with neurodegenerative disease. As with other BPSDs, these neural mechanisms alone do not completely account for the syndrome; individual, caregiver, and environmental factors also contribute to apathy...
April 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29657900/occipital-and-cingulate-hypometabolism-are-significantly-under-reported-on-18-fluorodeoxyglucose-positron-emission-tomography-scans-of-patients-with-lewy-body-dementia
#3
Moath Hamed, Frank Schraml, Jeffrey Wilson, James Galvin, Marwan N Sabbagh
Objective: To determine whether occipital and cingulate hypometabolism is being under-reported or missed on 18-fluorodeoxyglucose positron emission tomography (FDG-PET) CT scans in patients with Dementia with Lewy Bodies (DLB). Background: Recent studies have reported higher sensitivity and specificity for occipital and cingulate hypometabolism on FDG-PET of DLB patients. Methods: This retrospective chart review looked at regions of interest (ROI's) in FDG-PET CT scan reports in 35 consecutive patients with a clinical diagnosis of probable, possible, or definite DLB as defined by the latest DLB Consortium Report...
2018: Journal of Alzheimer's Disease and Parkinsonism
https://www.readbyqxmd.com/read/29653127/evaluation-of-early-chronic-functional-outcomes-and-their-relationship-to-pre-frontal-cortex-and-hippocampal-pathology-following-moderate-severe-traumatic-brain-injury
#4
Alina Arulsamy, Jason Teng, Holly Colton, Frances Corrigan, Lyndsey Collins-Praino
TBI is a significant risk factor for the development of dementia, with the interaction between structural damage from TBI and neuroinflammation potentially driving this relationship. This study investigated the early chronic post-TBI neuroinflammatory response and its relationship to both neurodegenerative pathology and functional impairment up to 3 months post-injury. Sprague-Dawley rats underwent either sham surgery or the Marmarou model of diffuse moderate-severe TBI. At 1-month and 3-months post-injury, a functional battery encompassing motor function, depressive-like behaviour, anxiety and cognition was performed...
April 10, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29649488/proteomics-based-identification-of-differential-plasma-proteins-and-changes-in-white-matter-integrity-as-markers-in-early-detection-of-mild-cognitive-impaired-subjects-at-high-risk-of-alzheimer-s-disease
#5
Abhai Kumar, Smita Singh, Ashish Verma, Vijay Nath Mishra
Mild cognitive impairment (MCI) is an intermediate stage of cognitive decline and dementia. The absence of specific diagnostic test for identification of MCI and AD. The current study aims to find proteomics based change in plasma proteins and diffusion tensor imaging (DTI) based white matter changes in MCI for early detection of prodromal Alzheimer's disease. Fifty cases of mild cognitive impairment and age matched control between (55-75 yrs) were screened on basis of Mini Mental State Examination (MMSE). Two dimensional gel electrophoresis and DTI imaging was performed in MCI and age matched control...
April 9, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29628321/association-of-hippocampal-substructure-resting-state-functional-connectivity-with-memory-performance-in-older-adults
#6
Stephen F Smagula, Helmet T Karim, Anusha Rangarajan, Fernando Pasquini Santos, Sossena C Wood, Tales Santini, John M Jakicic, Charles F Reynolds, Judy L Cameron, Abbe N Vallejo, Meryl A Butters, Caterina Rosano, Tamer S Ibrahim, Kirk I Erickson, Howard J Aizenstein
OBJECTIVES: Hippocampal hyperactivation marks preclinical dementia pathophysiology, potentially due to differences in the connectivity of specific medial temporal lobe structures. Our aims were to characterize the resting-state functional connectivity of medial temporal lobe sub-structures in older adults, and evaluate whether specific substructural (rather than global) functional connectivity relates to memory function. METHODS: In 15 adults (mean age: 69 years), we evaluated the resting state functional connectivity of medial temporal lobe substructures: dentate/Cornu Ammonis (CA) 4, CA1, CA2/3, subiculum, the molecular layer, entorhinal cortex, and parahippocampus...
March 13, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29614657/cerebral-amyloid-angiopathy-similarity-in-african-americans-and-caucasians-with-alzheimer-s-disease
#7
Dennis M Kamara, Umesh Gangishetti, Marla Gearing, Monica Willis-Parker, Liping Zhao, William T Hu, Lary C Walker
Cerebral amyloid angiopathy (CAA) of the Aβ type is variably present in the brains of patients with Alzheimer's disease (AD). CAA contributes to cognitive decline and increases the risk of lobar hemorrhage; because both AD-typical dementia and lobar hemorrhage are more common in African-Americans than in Caucasians, we postulated that African-Americans with AD might be particularly susceptible to CAA. To test this hypothesis, we analyzed CAA histopathologically in the large vessels and capillaries of autopsy-derived frontal, temporal, parietal, and occipital cortical samples from African-Americans (n = 18) and Caucasians (n = 19) with end-stage AD...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29614655/low-cerebrospinal-fluid-a%C3%AE-42-and-a%C3%AE-40-are-related-to-white-matter-lesions-in-cognitively-normal-elderly
#8
Ingmar Skoog, Silke Kern, Henrik Zetterberg, Svante Östling, Anne Börjesson-Hanson, Xinxin Guo, Kaj Blennow
BACKGROUND: Low cerebrospinal fluid (CSF) levels of Aβ42 may be the earliest manifestation of Alzheimer's disease (AD). Knowledge on how CSF Aβ interacts with different brain pathologies early in the disease process is limited. We examined how CSF Aβ markers relate to brain atrophy and white matter lesions (WMLs) in octogenarians with and without dementia to explore the earliest pathogenetic pathways of AD in the oldest old. OBJECTIVE: To study CSF amyloid biomarkers in relation to brain atrophy and WMLs in 85-year-olds with and without dementia...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29614645/structural-anatomical-investigation-of-long-term-memory-deficit-in-behavioral-frontotemporal-dementia
#9
Maxime Bertoux, Emma C Flanagan, Matthew Hobbs, Amparo Ruiz-Tagle, Carolina Delgado, Marcelo Miranda, Agustín Ibáñez, Andrea Slachevsky, Michael Hornberger
Although a growing body of work has shown that behavioral variant frontotemporal dementia (bvFTD) could present with severe amnesia in approximately half of cases, memory assessment is currently the clinical standard to distinguish bvFTD from Alzheimer's disease (AD). Thus, the concept of "relatively preserved episodic memory" in bvFTD remains the basis of its clinical distinction from AD and a criterion for bvFTD's diagnosis. This view is supported by the idea that bvFTD is not characterized by genuine amnesia and hippocampal degeneration, by contrast to AD...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29610105/cortical-thinning-and-cognitive-impairment-in-parkinson-s-disease-without-dementia
#10
Lijun Zhang, Ming Wang, Nicholas W Sterling, Eun-Young Lee, Paul J Eslinger, Daymond Wagner, Guangwei Du, Mechelle M Lewis, Young Truong, F DuBois Bowman, Xuemei Huang
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized clinically by motor dysfunction (bradykinesia, rigidity, tremor, and postural instability), and pathologically by the loss of dopaminergic neurons in the substantia nigra of the basal ganglia. Growing literature supports that cognitive deficits may also be present in PD, even in non-demented patients. Gray matter (GM) atrophy has been reported in PD and may be related to cognitive decline. This study investigated cortical thickness in non-demented PD subjects and elucidated its relationship to cognitive impairment using high-resolution T1-weighted brain MRI and comprehensive cognitive function scores from 71 non-demented PD and 48 control subjects matched for age, gender, and education...
March 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/29607919/-rapidly-deteriorated-lobar-intracerebral-hemorrhages-possible-association-of-varicella-zoster-virus-vasculopathy
#11
Jun Takeshita, Eiichi Nomura, Makoto Takemaru, Takahiro Himeno, Yutaka Shimoe, Masaru Kuriyama
A 75-year-old man having dementia and lifestyle related diseases developed a lobar intracerebral hemorrhage (LICH) in the left parietal and a small cerebellar infarction in the left occipital lobe. Many micro bleeds (MB) due to cerebral amyloid angiopathy (CAA) in the subcortical areas and multiple vascular stenosis were also found by MRI and MRA. He developed herpes zoster in his buttocks on day 6 of hospitalization and complicated with varicella zoster virus (VZV) meningitis with positive for VZV-DNA in the cerebrospinal fluid...
March 31, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29599717/gray-matter-network-disruptions-and-regional-amyloid-beta-in-cognitively-normal-adults
#12
Mara Ten Kate, Pieter Jelle Visser, Hovagim Bakardjian, Frederik Barkhof, Sietske A M Sikkes, Wiesje M van der Flier, Philip Scheltens, Harald Hampel, Marie-Odile Habert, Bruno Dubois, Betty M Tijms
The accumulation of amyloid plaques is one of the earliest pathological changes in Alzheimer's disease (AD) and may occur 20 years before the onset of symptoms. Examining associations between amyloid pathology and other early brain changes is critical for understanding the pathophysiological underpinnings of AD. Alterations in gray matter networks might already start at early preclinical stages of AD. In this study, we examined the regional relationship between amyloid aggregation measured with positron emission tomography (PET) and gray matter network measures in elderly subjects with subjective memory complaints...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29599716/atrophy-in-the-thalamus-but-not-cerebellum-is-specific-for-c9orf72-ftd-and-als-patients-an-atlas-based-volumetric-mri-study
#13
Sonja Schönecker, Christiane Neuhofer, Markus Otto, Albert Ludolph, Jan Kassubek, Bernhard Landwehrmeyer, Sarah Anderl-Straub, Elisa Semler, Janine Diehl-Schmid, Catharina Prix, Christian Vollmar, Juan Fortea, Hans-Jürgen Huppertz, Thomas Arzberger, Dieter Edbauer, Berend Feddersen, Marianne Dieterich, Matthias L Schroeter, Alexander E Volk, Klaus Fließbach, Anja Schneider, Johannes Kornhuber, Manuel Maler, Johannes Prudlo, Holger Jahn, Tobias Boeckh-Behrens, Adrian Danek, Thomas Klopstock, Johannes Levin
Background: The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types of characteristic protein depositions containing either TDP-43 or so-called dipeptide repeat proteins that extend beyond frontal and temporal regions. Thalamus and cerebellum seem to be preferentially affected by the dipeptide repeat pathology unique to C9orf72 mutation carriers. Objective: This study aimed to determine if mutation carriers showed an enhanced degree of thalamic and cerebellar atrophy compared to sporadic patients or healthy controls...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29581708/study-of-the-influence-of-age-in-18-f-fdg-pet-images-using-a-data-driven-approach-and-its-evaluation-in-alzheimer-s-disease
#14
Jiehui Jiang, Yiwu Sun, Hucheng Zhou, Shaoping Li, Zhemin Huang, Ping Wu, Kuangyu Shi, Chuantao Zuo, Alzheimer's Disease Neuroimaging Initiative
Objectives: 18 F-FDG PET scan is one of the most frequently used neural imaging scans. However, the influence of age has proven to be the greatest interfering factor for many clinical dementia diagnoses when analyzing18 F-FDG PET images, since radiologists encounter difficulties when deciding whether the abnormalities in specific regions correlate with normal aging, disease, or both. In the present paper, the authors aimed to define specific brain regions and determine an age-correction mathematical model...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29578490/frontotemporal-dementia-and-chorea-associated-with-a-compound-heterozygous-trem2-mutation
#15
Veronica Redaelli, Ettore Salsano, Lara Colleoni, Paola Corbetta, Giovanni Tringali, Angelo Del Sole, Giorgio Giaccone, Giacomina Rossi
Frontotemporal dementia (FTD) is clinically characterized by behavioral changes, language impairment, and executive dysfunction. FTD usually belongs to the frontotemporal lobar degeneration (FTLD) disease group, and its familial forms are dominantly inherited and linked to a group of genes relevant to frontal and temporal brain pathology, such as MAPT, GRN, C9ORF72, TARDBP, CHMP2B, VCP, and FUS. However, FTD can also be associated with different clinical or pathological phenotypes caused by mutations in other genes, whose heredity can be dominant or recessive...
March 23, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29578481/deficits-in-regional-cerebral-blood-flow-on-brain-spect-predict-treatment-resistant-depression
#16
Daniel G Amen, Derek V Taylor, Somayeh Meysami, Cyrus A Raji
BACKGROUND: Depression remains an important risk factor for Alzheimer's disease, yet few neuroimaging biomarkers are available to identify treatment response in depression. OBJECTIVE: To analyze and compare functional perfusion neuroimaging in persons with treatment resistant depression (TRD) compared to those experiencing full remission. METHODS: A total of 951 subjects from a community psychiatry cohort were scanned with perfusion single photon emission computed tomography (SPECT) of the brain in both resting and task related settings...
March 22, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29573594/looking-but-not-seeing-increased-eye-fixations-in-behavioural-variant-frontotemporal-dementia
#17
Rosalind Hutchings, Romina Palermo, Jason Bruggemann, John R Hodges, Olivier Piguet, Fiona Kumfor
Face processing plays a central role in human communication, with the eye region a particularly important cue for discriminating emotions. Indeed, reduced attention to the eyes has been argued to underlie social deficits in a number of clinical populations. Despite well-established impairments in facial affect recognition in behavioural-variant frontotemporal dementia, whether these patients also have perturbed facial scanning is yet to be investigated. The current study employed eye tracking to record visual scanning of faces in 20 behavioural-variant frontotemporal dementia patients and 21 controls...
February 27, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29572571/exploring-the-relationship-between-motor-impairment-vascular-burden-and-cognition-in-parkinson-s-disease
#18
Tanja Stojkovic, Elka Stefanova, Ivan Soldatovic, Vladana Markovic, Iva Stankovic, Igor Petrovic, Federica Agosta, Sebastiano Galantucci, Massimo Filippi, Vladimir Kostic
OBJECTIVE: To determine frequency and type of cognitive disorders in cross-sectional analysis of a Parkinson's disease (PD) cohort, and explore its relations to motor symptoms, modifiable vascular risk factors and white matter lesions (WML) volume. METHODS: In a group of 133 PD patients, mild cognitive impairment (PD-MCI) and dementia (PDD) were diagnosed according to Movement Disorders Society Task Force criteria (level 2 for PD-MCI). Detailed motor measurements were applied, including rigidity, axial, bradykinesia, tremor and postural instability gait disorders (PIGD) scores...
March 23, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29571955/eye-movement-parameters-and-cognitive-functions-in-parkinson-s-disease-patients-without-dementia
#19
Oscar Wh Wong, Anne Yy Chan, Adrian Wong, Claire Ky Lau, Jonas Hm Yeung, Vincent Ct Mok, Linda Cw Lam, Sandra Chan
BACKGROUND: Cognitive deficits and eye movement abnormalities have been demonstrated to be detectable early clinical manifestations of Parkinson's disease. Understanding the relationship between these phenotypes may yield insight into the underlying anatomical pathways, assisting in the search for simple non-invasive markers of early neurodegeneration. OBJECTIVE: To explore the correlations between eye movement parameters with multi-domain cognitive functions in patients suffering from Parkinson's disease without dementia...
March 15, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29568692/longitudinal-evaluation-of-tau-p301l-transgenic-mice-reveals-no-cognitive-impairments-at-17-months-of-age
#20
Brianne A Kent, Christopher J Heath, Chi Hun Kim, Rosemary Ahrens, Paul E Fraser, Peter St George-Hyslop, Timothy J Bussey, Lisa M Saksida
Introduction: Tau is a microtubule-associated binding protein implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD). These diseases result in the intracellular accumulation of hyperphosphorylated tau in the form of neurofibrillary tangles, the presence of which is associated with cognitive deficits. Methods: We conducted a longitudinal behavioral study to provide a profile of the TgTau(P301L)23027 transgenic mouse in multiple cognitive domains across multiple ages...
January 2018: Brain and Behavior
keyword
keyword
67487
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"